@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2086: (2016-02-04 )
MNTDPLLPGFDYLTLHTSAARLRVAVKGSGPPLLLLHGYPQTHLAWHRIAPRLAEDYSVVLADLRGYGESRALDEEGADYSKAALARDQLETMGQLGFERFAVIGHDRGARVGYRLALDHPQAVAAFVSLTVVPILDNWAAVNKVFALNAYHWFLLAQPYDLPERLIGADPEHFLDYTLRRMAQGRDIYHPQALESYRRAFRDPAVRHAMCEDYRAAVGVDADADQADRDAGRRLQCPVQVLWQERPYAAGQHPLEIWKTWAGQVEGAAIGASHMLPEDAPDAVLEHLLGFLASHREALR
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70--.--....--...80........90........100.......110.......120.......130.......140.......150.......160.......170.......180-...-...--.190.......200.......210.......220.......230.......240.......-250..---.-....260---.......270.......280.......290.......300
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNTDPLLPGF
D
Y
L
T
L
HTS
A
A
R
L
R
V
A
V
KGSGP
P
L
L
L
L
HGYP
Q
T
H
L
A
W
H
R
I
A
P
R
L
A
E
D
Y
S
V
V
L
A
D
L
RGYGESR--A--LDEE--GAD
Y
S
K
A
A
L
A
R
D
Q
L
E
T
M
G
Q
L
G
F
E
R
F
A
V
IGHDRGA
R
V
G
Y
R
L
ALD
H
P
Q
A
V
A
A
F
V
S
L
T
V
V
P
ILD
N
W
A
A
V
N
K
V
F
A
L
N
A
Y
H
W
F
L
L
AQPYD
L
P
E
R
L
IGA
D
P
E
H
F
L
D
Y
T
L
R
R
M
-AQG-RDI--Y
H
P
Q
A
L
E
S
Y
R
R
A
F
RD
P
A
V
R
H
A
M
C
E
D
Y
R
A
AVGVDADADQ
A
D
R
DAGRRLQC
P
V
Q
V
L
WQERPYA-AGQ
H
P
---
L
-
E
I
W
K
T
W
A---GQVEGAAIGASHMLPEDA
P
D
A
V
L
E
H
L
L
G
F
L
A
S
H
R
E
ALR
69
Fugue
96.89
100%
-108
- C1 -
4B9E
11
?
A:
[5-301]
---
D
P
L
L
P
G
F
D
Y
L
T
L
H
T
S
A
A
R
L
R
V
A
V
K
G
S
G
P
P
L
L
L
L
H
G
Y
P
Q
T
H
L
A
W
H
R
I
A
P
R
L
A
E
D
Y
S
V
V
L
A
D
L
R
G
Y
G
E
S
R
--
A
--
L
D
E
E
--
G
A
D
Y
S
K
A
A
L
A
R
D
Q
L
E
T
M
G
Q
L
G
F
E
R
F
A
V
I
G
H
D
R
G
A
R
V
G
Y
R
L
A
L
D
H
P
Q
A
V
A
A
F
V
S
L
T
V
V
P
I
L
D
N
W
A
A
V
N
K
V
F
A
L
N
A
Y
H
W
F
L
L
A
Q
P
Y
D
L
P
E
R
L
I
G
A
D
P
E
H
F
L
D
Y
T
L
R
R
M
-
A
Q
G
-
R
D
I
--
Y
H
P
Q
A
L
E
S
Y
R
R
A
F
R
D
P
A
V
R
H
A
M
C
E
D
Y
R
A
A
V
G
V
D
A
D
A
D
Q
A
D
R
D
A
G
R
R
L
Q
C
P
V
Q
V
L
W
Q
E
R
P
Y
A
-
A
G
Q
H
P
---
L
-
E
I
W
K
T
W
A
---
G
Q
V
E
G
A
A
I
G
A
S
H
M
L
P
E
D
A
P
D
A
V
L
E
H
L
L
G
F
L
A
S
H
R
E
A
L
R
2
PsiBlast_PDB
96.89
100%
-108
- C1 -
4B9E
11
?
A:
[5-301]
---
D
P
L
L
P
G
F
D
Y
L
T
L
H
T
S
A
A
R
L
R
V
A
V
K
G
S
G
P
P
L
L
L
L
H
G
Y
P
Q
T
H
L
A
W
H
R
I
A
P
R
L
A
E
D
Y
S
V
V
L
A
D
L
R
G
Y
G
E
S
R
--
A
--
L
D
E
E
--
G
A
D
Y
S
K
A
A
L
A
R
D
Q
L
E
T
M
G
Q
L
G
F
E
R
F
A
V
I
G
H
D
R
G
A
R
V
G
Y
R
L
A
L
D
H
P
Q
A
V
A
A
F
V
S
L
T
V
V
P
I
L
D
N
W
A
A
V
N
K
V
F
A
L
N
A
Y
H
W
F
L
L
A
Q
P
Y
D
L
P
E
R
L
I
G
A
D
P
E
H
F
L
D
Y
T
L
R
R
M
-
A
Q
G
-
R
D
I
--
Y
H
P
Q
A
L
E
S
Y
R
R
A
F
R
D
P
A
V
R
H
A
M
C
E
D
Y
R
A
A
V
G
V
D
A
D
A
D
Q
A
D
R
D
A
G
R
R
L
Q
C
P
V
Q
V
L
W
Q
E
R
P
Y
A
-
A
G
Q
H
P
---
L
-
E
I
W
K
T
W
A
---
G
Q
V
E
G
A
A
I
G
A
S
H
M
L
P
E
D
A
P
D
A
V
L
E
H
L
L
G
F
L
A
S
H
R
E
A
L
R
1
PsiBlast_PDB
96.65
100%
-108
- C1 -
4B9A
15
?
A:
[4-301]
--
T
D
P
L
L
P
G
F
D
Y
L
T
L
H
T
S
A
A
R
L
R
V
A
V
K
G
S
G
P
P
L
L
L
L
H
G
Y
P
Q
T
H
L
A
W
H
R
I
A
P
R
L
A
E
D
Y
S
V
V
L
A
D
L
R
G
Y
G
E
S
R
--
A
--
L
D
E
E
--
G
A
D
Y
S
K
A
A
L
A
R
D
Q
L
E
T
M
G
Q
L
G
F
E
R
F
A
V
I
G
H
D
R
G
A
R
V
G
Y
R
L
A
L
D
H
P
Q
A
V
A
A
F
V
S
L
T
V
V
P
I
L
D
N
W
A
A
V
N
K
V
F
A
L
N
A
Y
H
W
F
L
L
A
Q
P
Y
D
L
P
E
R
L
I
G
A
D
P
E
H
F
L
D
Y
T
L
R
R
M
-
A
Q
G
-
R
D
I
--
Y
H
P
Q
A
L
E
S
Y
R
R
A
F
R
D
P
A
V
R
H
A
M
C
E
D
Y
R
A
A
V
G
V
D
A
D
A
D
Q
A
D
R
D
A
G
R
R
L
Q
C
P
V
Q
V
L
W
Q
E
R
P
Y
A
-
A
G
Q
H
P
---
L
-
E
I
W
K
T
W
A
---
G
Q
V
E
G
A
A
I
G
A
S
H
M
L
P
E
D
A
P
D
A
V
L
E
H
L
L
G
F
L
A
S
H
R
E
A
L
R
3
PsiBlast_PDB
95.98
99%
-110
- C1 -
4BAZ
17
?
A:
[4-301]
--
T
D
P
L
L
P
G
F
D
Y
L
T
L
H
T
S
A
A
R
L
R
V
A
V
K
G
S
G
P
P
L
L
L
L
H
G
Y
P
Q
T
H
L
A
W
H
R
I
A
P
R
L
A
E
D
Y
S
V
V
L
A
D
L
R
G
Y
G
E
S
R
--
A
--
L
D
----
G
A
D
Y
S
K
A
A
L
A
R
D
Q
L
E
T
M
G
Q
L
G
F
E
R
F
A
V
I
G
H
D
R
G
A
R
V
G
Y
R
L
A
L
D
H
P
Q
A
V
A
A
F
V
S
L
T
V
V
P
I
L
D
N
W
A
A
V
N
K
V
F
A
L
N
A
Y
H
W
F
L
L
A
Q
P
Y
D
L
P
E
R
L
I
G
A
D
P
E
H
F
L
D
Y
T
L
R
R
M
-
A
Q
G
-
R
D
I
--
Y
H
P
Q
A
L
E
S
Y
R
R
A
F
R
D
P
A
V
R
H
A
M
C
E
D
Y
R
A
A
V
G
V
D
A
D
A
D
Q
A
D
R
D
A
G
R
R
L
Q
C
P
V
Q
V
L
W
E
E
R
P
Y
A
-
A
G
Q
H
P
---
L
-
E
I
W
K
T
W
A
---
G
Q
V
E
G
A
A
I
G
A
S
H
M
L
P
E
D
A
P
D
A
V
L
E
H
L
L
G
F
L
A
S
H
R
E
A
L
R
6
PsiBlast_PDB
95.65
99%
-108
- C1 -
4BAT
11
?
A:
[5-300]
---
D
P
L
L
P
G
F
D
Y
L
T
L
H
T
S
A
A
R
L
R
V
A
V
K
G
S
G
P
P
L
L
L
L
H
G
Y
P
Q
T
H
L
A
W
H
R
I
A
P
R
L
A
E
D
Y
S
V
V
L
A
D
L
R
G
Y
G
E
S
R
--
A
--
L
D
E
E
--
G
A
D
Y
S
K
A
A
L
A
R
D
Q
L
E
T
M
G
Q
L
G
F
E
R
F
A
V
I
G
H
D
R
G
A
R
V
G
Y
R
L
A
L
D
H
P
Q
A
V
A
A
F
V
S
L
D
V
V
P
I
L
D
N
W
A
A
V
N
K
V
F
A
L
N
A
Y
H
W
F
L
L
A
Q
P
Y
D
L
P
E
R
L
I
G
A
D
P
E
H
F
L
D
Y
T
L
R
R
M
-
A
Q
G
-
R
D
I
--
Y
H
P
Q
A
L
E
S
Y
R
R
A
F
R
D
P
A
V
R
H
A
M
C
E
D
Y
R
A
A
V
G
V
D
A
D
A
D
Q
A
D
R
D
A
G
R
R
L
Q
C
P
V
Q
V
L
W
Q
E
R
P
Y
A
-
A
G
Q
H
P
---
L
-
E
I
W
K
T
W
A
---
G
Q
V
E
G
A
A
I
G
A
S
H
M
L
P
E
D
A
P
D
A
V
L
E
H
L
L
G
F
L
A
S
H
R
E
A
L
-
5
PsiBlast_PDB
95.57
99%
-109
- C1 -
4BAU
17
?
A:
[5-301]
---
D
P
L
L
P
G
F
D
Y
L
T
L
H
T
S
A
A
R
L
R
V
A
V
K
G
S
G
P
P
L
L
L
L
H
G
Y
P
Q
T
H
L
A
W
H
R
I
A
P
R
L
A
E
D
Y
S
V
V
L
A
D
L
R
G
Y
G
E
S
R
--
A
--
L
D
----
G
A
D
Y
S
K
A
A
L
A
R
D
Q
L
E
T
M
G
Q
L
G
F
E
R
F
A
V
I
G
H
D
R
G
A
R
V
G
Y
R
L
A
L
D
H
P
Q
A
V
A
A
F
V
S
L
D
V
V
P
I
L
D
N
W
A
A
V
N
K
V
F
A
L
N
A
Y
H
W
F
L
L
A
Q
P
Y
D
L
P
E
R
L
I
G
A
D
P
E
H
F
L
D
Y
T
L
R
R
M
-
A
Q
G
-
R
D
I
--
Y
H
P
Q
A
L
E
S
Y
R
R
A
F
R
D
P
A
V
R
H
A
M
C
E
D
Y
R
A
A
V
G
V
D
A
D
A
D
Q
A
D
R
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A
G
R
R
L
Q
C
P
V
Q
V
L
W
Q
E
R
P
Y
A
-
A
G
Q
H
P
---
L
-
E
I
W
K
T
W
A
---
G
Q
V
E
G
A
A
I
G
A
S
H
M
L
P
E
D
A
P
D
A
V
L
E
H
L
L
G
F
L
A
S
H
R
E
A
L
R
4
PsiBlast_PDB
95.31
99%
-110
- C1 -
4BB0
17
?
A:
[5-301]
---
D
P
L
L
P
G
F
D
Y
L
T
L
H
T
S
A
A
R
L
R
V
A
V
K
G
S
G
P
P
L
L
L
L
H
G
Y
P
Q
T
H
L
A
W
H
R
I
A
P
R
L
A
E
D
Y
S
V
V
L
A
D
L
R
G
Y
G
E
S
R
--
A
--
L
D
----
G
A
D
Y
S
K
A
A
L
A
R
D
Q
L
E
T
M
G
Q
L
G
F
E
R
F
A
V
I
G
H
D
R
G
A
R
V
G
Y
R
L
A
L
D
H
P
Q
A
V
A
A
F
V
S
L
T
V
V
P
I
L
D
N
W
A
A
V
N
K
V
F
A
L
N
A
Y
H
W
F
L
L
A
Q
P
Y
D
L
P
E
R
L
I
G
A
D
P
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H
F
L
D
Y
T
L
R
R
M
-
A
Q
G
-
R
D
I
--
Y
H
P
Q
A
L
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Y
R
R
A
F
R
D
P
A
V
R
H
A
M
C
E
D
Y
R
A
A
V
G
V
D
A
D
A
D
Q
A
D
R
D
A
G
R
R
L
Q
C
P
V
Q
V
L
W
E
E
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P
Y
A
-
A
G
Q
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---
L
-
E
I
W
K
T
W
A
---
G
Q
V
E
G
A
A
I
G
A
S
H
M
L
P
E
D
A
P
D
A
V
L
E
H
L
L
G
F
L
A
S
H
R
E
A
L
R
9
PsiBlast_PDB
76.21
45%
-101
- C1 -
3R3W
4
DEHA_RHOPA
A:
[9-302]
-----
L
F
P
G
F
G
S
E
W
I
N
T
S
S
G
R
I
F
A
R
V
G
G
D
G
P
P
L
L
L
L
H
G
F
P
Q
T
H
V
M
W
H
R
V
A
P
K
L
A
E
R
F
K
V
I
V
A
D
L
P
G
Y
G
W
S
D
--
M
PE
S
D
E
Q
--
H
T
P
Y
T
K
R
A
M
A
K
Q
L
I
E
A
M
E
Q
L
G
H
V
H
F
A
L
A
G
H
N
R
G
A
R
V
S
Y
R
L
A
L
D
S
P
G
R
L
S
K
L
A
V
L
D
I
L
P
T
Y
E
Y
W
Q
R
M
N
R
A
Y
A
L
K
I
Y
H
W
S
F
L
A
Q
P
A
P
L
P
E
N
L
L
G
G
D
P
D
F
Y
V
K
A
K
L
A
S
W
-
T
R
A
-
G
D
L
SA
F
D
P
R
A
V
E
H
Y
R
I
A
F
A
D
P
M
R
R
H
V
M
C
E
D
Y
R
A
G
A
Y
A
D
F
E
H
D
K
I
D
V
E
A
G
N
K
I
P
V
P
M
L
A
L
W
G
A
S
G
I
A
--
A
A
T
P
---
L
-
D
V
W
R
K
W
A
---
S
D
V
Q
G
A
P
I
E
S
G
H
F
L
P
E
E
A
P
D
Q
T
A
E
A
L
V
R
F
F
S
A
------
22
PsiBlast_CBE
75.41
45%
-103
- C1 -
3R3Z
1
DEHA_RHOPA
C:
[9-301]
-----
L
F
P
G
F
G
S
E
W
I
N
T
S
S
G
R
I
F
A
R
V
G
G
D
G
P
P
L
L
L
L
H
G
F
P
Q
T
H
V
M
W
H
R
V
A
P
K
L
A
E
R
F
K
V
I
V
A
D
L
P
G
Y
G
W
S
D
--
M
PE
S
D
E
Q
--
H
T
P
Y
T
K
R
A
M
A
K
Q
L
I
E
A
M
E
Q
L
G
H
V
H
F
A
L
A
G
H
D
R
G
A
R
V
S
Y
R
L
A
L
D
S
P
G
R
L
S
K
L
A
V
L
D
I
L
P
T
Y
E
Y
W
Q
R
M
N
R
A
Y
A
L
K
I
Y
H
W
S
F
L
A
Q
P
A
P
L
P
E
N
L
L
G
G
D
P
D
F
Y
V
K
A
K
L
A
S
W
-
T
R
A
-
G
D
L
SA
F
D
P
R
A
V
E
H
Y
R
I
A
F
A
D
P
M
R
R
H
V
M
C
E
D
Y
R
A
G
A
Y
A
D
F
E
H
D
K
I
D
V
E
A
G
N
K
I
P
V
P
M
L
A
L
W
G
A
S
G
I
A
Q
S
A
A
T
P
---
L
-
D
V
W
R
K
W
A
---
S
D
V
Q
G
A
P
I
E
S
G
H
F
L
P
E
E
A
P
D
Q
T
A
E
A
L
V
R
F
F
S
-------
27
PsiBlast_CBE
75.38
45%
-105
- C1 -
3R40
1
DEHA_RHOPA
B:
[9-301]
-----
L
F
P
G
F
G
S
E
W
I
N
T
S
S
G
R
I
F
A
R
V
G
G
D
G
P
P
L
L
L
L
H
G
F
P
Q
T
H
V
M
W
H
R
V
A
P
K
L
A
E
R
F
K
V
I
V
A
D
L
P
G
Y
G
W
S
D
--
M
PE
S
D
E
Q
--
H
T
P
Y
T
K
R
A
M
A
K
Q
L
I
E
A
M
E
Q
L
G
H
V
H
F
A
L
A
G
H
N
R
G
A
R
V
S
Y
R
L
A
L
D
S
P
G
R
L
S
K
L
A
V
L
D
I
L
P
T
Y
E
Y
W
Q
R
M
N
R
A
Y
A
L
K
I
Y
H
W
S
F
L
A
Q
P
A
P
L
P
E
N
L
L
G
G
D
P
D
F
Y
V
K
A
K
L
A
S
W
-
T
R
A
-
G
D
L
SA
F
D
P
R
A
V
E
H
Y
R
I
A
F
A
D
P
M
R
R
H
V
M
C
E
D
Y
R
A
G
A
Y
A
D
F
E
H
D
K
I
D
V
E
A
G
N
K
I
P
V
P
M
L
A
L
W
G
A
---------
P
---
L
-
D
V
W
R
K
W
A
---
S
D
V
Q
G
A
P
I
E
S
G
H
F
L
P
E
E
A
P
D
Q
T
A
E
A
L
V
R
F
F
S
-------
26
PsiBlast_CBE
75.33
45%
-105
- C1 -
3R3U
1
DEHA_RHOPA
B:
[9-302]
-----
L
F
P
G
F
G
S
E
W
I
N
T
S
S
G
R
I
F
A
R
V
G
G
D
G
P
P
L
L
L
L
H
G
F
P
Q
T
H
V
M
W
H
R
V
A
P
K
L
A
E
R
F
K
V
I
V
A
D
L
P
G
Y
G
W
S
D
--
M
PE
S
D
E
Q
--
H
T
P
Y
T
K
R
A
M
A
K
Q
L
I
E
A
M
E
Q
L
G
H
V
H
F
A
L
A
G
H
D
R
G
A
R
V
S
Y
R
L
A
L
D
S
P
G
R
L
S
K
L
A
V
L
D
I
L
P
T
Y
E
Y
W
Q
R
M
N
R
A
Y
A
L
K
I
Y
H
W
S
F
L
A
Q
P
A
P
L
P
E
N
L
L
G
G
D
P
D
F
Y
V
K
A
K
L
A
S
W
-
T
R
A
-
G
D
L
SA
F
D
P
R
A
V
E
H
Y
R
I
A
F
A
D
P
M
R
R
H
V
M
C
E
D
Y
R
A
G
A
Y
A
D
F
E
H
D
K
I
D
V
E
A
G
N
K
I
P
V
P
M
L
A
L
W
G
A
---------
P
---
L
-
D
V
W
R
K
W
A
---
S
D
V
Q
G
A
P
I
E
S
G
H
F
L
P
E
E
A
P
D
Q
T
A
E
A
L
V
R
F
F
S
A
A
-----
10
PsiBlast_PDB
75.03
45%
-102
- C1 -
3R3X
4
DEHA_RHOPA
A:
[9-302]
-----
L
F
P
G
F
G
S
E
W
I
N
T
S
S
G
R
I
F
A
R
V
G
G
D
G
P
P
L
L
L
L
H
G
F
P
Q
T
H
V
M
W
H
R
V
A
P
K
L
A
E
R
F
K
V
I
V
A
D
L
P
G
Y
G
W
S
D
--
M
PE
S
D
E
Q
--
H
T
P
Y
T
K
R
A
M
A
K
Q
L
I
E
A
M
E
Q
L
G
H
V
H
F
A
L
A
G
H
N
R
G
A
R
V
S
Y
R
L
A
L
D
S
P
G
R
L
S
K
L
A
V
L
D
I
L
P
T
Y
E
Y
W
Q
R
M
N
R
A
Y
A
L
K
I
Y
H
W
S
F
L
A
Q
P
A
P
L
P
E
N
L
L
G
G
D
P
D
F
Y
V
K
A
K
L
A
S
W
-
T
R
A
-
G
D
L
SA
F
D
P
R
A
V
E
H
Y
R
I
A
F
A
D
P
M
R
R
H
V
M
C
E
D
Y
R
A
G
A
Y
A
D
F
E
H
D
K
I
D
V
E
A
G
N
K
I
P
V
P
M
L
A
L
W
G
A
S
G
I
A
----
T
P
---
L
-
D
V
W
R
K
W
A
---
S
D
V
Q
G
A
P
I
E
S
G
H
F
L
P
E
E
A
P
D
Q
T
A
E
A
L
V
R
F
F
S
A
------
23
PsiBlast_CBE
74.99
45%
-102
- C1 -
3R3Z
1
DEHA_RHOPA
B:
[9-302]
-----
L
F
P
G
F
G
S
E
W
I
N
T
S
S
G
R
I
F
A
R
V
G
G
D
G
P
P
L
L
L
L
H
G
F
P
Q
T
H
V
M
W
H
R
V
A
P
K
L
A
E
R
F
K
V
I
V
A
D
L
P
G
Y
G
W
S
D
--
M
PE
S
D
E
Q
--
H
T
P
Y
T
K
R
A
M
A
K
Q
L
I
E
A
M
E
Q
L
G
H
V
H
F
A
L
A
G
H
D
R
G
A
R
V
S
Y
R
L
A
L
D
S
P
G
R
L
S
K
L
A
V
L
D
I
L
P
T
Y
E
Y
W
Q
R
M
N
R
A
Y
A
L
K
I
Y
H
W
S
F
L
A
Q
P
A
P
L
P
E
N
L
L
G
G
D
P
D
F
Y
V
K
A
K
L
A
S
W
-
T
R
A
-
G
D
L
SA
F
D
P
R
A
V
E
H
Y
R
I
A
F
A
D
P
M
R
R
H
V
M
C
E
D
Y
R
A
G
A
Y
A
D
F
E
H
D
K
I
D
V
E
A
G
N
K
I
P
V
P
M
L
A
L
W
G
A
S
--------
P
---
L
-
D
V
W
R
K
W
A
---
S
D
V
Q
G
A
P
I
E
S
G
H
F
L
P
E
E
A
P
D
Q
T
A
E
A
L
V
R
F
F
S
A
A
-----
12
PsiBlast_PDB
74.76
45%
-101
- C1 -
3R41
3
DEHA_RHOPA
A:
[9-302]
-----
L
F
P
G
F
G
S
E
W
I
N
T
S
S
G
R
I
F
A
R
V
G
G
D
G
P
P
L
L
L
L
H
G
F
P
Q
T
H
V
M
W
H
R
V
A
P
K
L
A
E
R
F
K
V
I
V
A
D
L
P
G
Y
G
W
S
D
--
M
PE
S
D
E
Q
--
H
T
P
Y
T
K
R
A
M
A
K
Q
L
I
E
A
M
E
Q
L
G
H
V
H
F
A
L
A
G
H
D
R
G
A
R
V
S
Y
R
L
A
L
D
S
P
G
R
L
S
K
L
A
V
L
D
I
L
P
T
Y
E
Y
W
Q
R
M
N
R
A
Y
A
L
K
I
Y
H
W
S
F
L
A
Q
P
A
P
L
P
E
N
L
L
G
G
D
P
D
F
Y
V
K
A
K
L
A
S
W
-
T
R
A
-
G
D
L
SA
F
D
P
R
A
V
E
H
Y
R
I
A
F
A
D
P
M
R
R
H
V
M
C
E
D
Y
R
A
G
A
Y
A
D
F
E
H
D
K
I
D
V
E
A
G
N
K
I
P
V
P
M
L
A
L
W
G
A
S
G
I
A
Q
S
A
A
T
P
---
L
-
D
V
W
R
K
W
A
---
S
D
V
Q
G
A
P
I
E
S
G
N
F
L
P
E
E
A
P
D
Q
T
A
E
A
L
V
R
F
F
S
A
------
30
PsiBlast_CBE
74.57
45%
-101
- C1 -
3R3V
2
DEHA_RHOPA
B:
[9-302]
-----
L
F
P
G
F
G
S
E
W
I
N
T
S
S
G
R
I
F
A
R
V
G
G
D
G
P
P
L
L
L
L
H
G
F
P
Q
T
H
V
M
W
H
R
V
A
P
K
L
A
E
R
F
K
V
I
V
A
D
L
P
G
Y
G
W
S
D
--
M
PE
S
D
E
Q
--
H
T
P
Y
T
K
R
A
M
A
K
Q
L
I
E
A
M
E
Q
L
G
H
V
H
F
A
L
A
G
H
N
R
G
A
R
V
S
Y
R
L
A
L
D
S
P
G
R
L
S
K
L
A
V
L
D
I
L
P
T
Y
E
Y
W
Q
R
M
N
R
A
Y
A
L
K
I
Y
H
W
S
F
L
A
Q
P
A
P
L
P
E
N
L
L
G
G
D
P
D
F
Y
V
K
A
K
L
A
S
W
-
T
R
A
-
G
D
L
SA
F
D
P
R
A
V
E
H
Y
R
I
A
F
A
D
P
M
R
R
H
V
M
C
E
D
Y
R
A
G
A
Y
A
D
F
E
H
D
K
I
D
V
E
A
G
N
K
I
P
V
P
M
L
A
L
W
G
A
S
G
------
T
P
---
L
-
D
V
W
R
K
W
A
---
S
D
V
Q
G
A
P
I
E
S
G
H
F
L
P
E
E
A
P
D
Q
T
A
E
A
L
V
R
F
F
S
A
------
8
PsiBlast_PDB
74.57
45%
-101
- C1 -
3R3Z
1
DEHA_RHOPA
A:
[9-302]
-----
L
F
P
G
F
G
S
E
W
I
N
T
S
S
G
R
I
F
A
R
V
G
G
D
G
P
P
L
L
L
L
H
G
F
P
Q
T
H
V
M
W
H
R
V
A
P
K
L
A
E
R
F
K
V
I
V
A
D
L
P
G
Y
G
W
S
D
--
M
PE
S
D
E
Q
--
H
T
P
Y
T
K
R
A
M
A
K
Q
L
I
E
A
M
E
Q
L
G
H
V
H
F
A
L
A
G
H
D
R
G
A
R
V
S
Y
R
L
A
L
D
S
P
G
R
L
S
K
L
A
V
L
D
I
L
P
T
Y
E
Y
W
Q
R
M
N
R
A
Y
A
L
K
I
Y
H
W
S
F
L
A
Q
P
A
P
L
P
E
N
L
L
G
G
D
P
D
F
Y
V
K
A
K
L
A
S
W
-
T
R
A
-
G
D
L
SA
F
D
P
R
A
V
E
H
Y
R
I
A
F
A
D
P
M
R
R
H
V
M
C
E
D
Y
R
A
G
A
Y
A
D
F
E
H
D
K
I
D
V
E
A
G
N
K
I
P
V
P
M
L
A
L
W
G
A
S
G
I
A
Q
S
A
A
T
P
---
L
-
D
V
W
R
K
W
A
---
S
D
V
Q
G
A
P
I
E
S
G
H
F
L
P
E
E
A
P
D
Q
T
A
E
A
L
V
R
F
F
S
A
A
P
----
31
PsiBlast_CBE
74.53
45%
-103
- C1 -
3R41
3
DEHA_RHOPA
B:
[9-302]
-----
L
F
P
G
F
G
S
E
W
I
N
T
S
S
G
R
I
F
A
R
V
G
G
D
G
P
P
L
L
L
L
H
G
F
P
Q
T
H
V
M
W
H
R
V
A
P
K
L
A
E
R
F
K
V
I
V
A
D
L
P
G
Y
G
W
S
D
--
M
PE
S
D
E
Q
--
H
T
P
Y
T
K
R
A
M
A
K
Q
L
I
E
A
M
E
Q
L
G
H
V
H
F
A
L
A
G
H
D
R
G
A
R
V
S
Y
R
L
A
L
D
S
P
G
R
L
S
K
L
A
V
L
D
I
L
P
T
Y
E
Y
W
Q
R
M
N
R
A
Y
A
L
K
I
Y
H
W
S
F
L
A
Q
P
A
P
L
P
E
N
L
L
G
G
D
P
D
F
Y
V
K
A
K
L
A
S
W
-
T
R
A
-
G
D
L
SA
F
D
P
R
A
V
E
H
Y
R
I
A
F
A
D
P
M
R
R
H
V
M
C
E
D
Y
R
A
G
A
Y
A
D
F
E
H
D
K
I
D
V
E
A
G
N
K
I
P
V
P
M
L
A
L
W
G
A
S
G
I
A
Q
S
A
A
T
P
---
L
-
D
V
W
R
K
W
A
---
S
D
V
Q
G
A
P
I
E
S
G
N
F
L
P
E
E
A
P
D
Q
T
A
E
A
L
V
R
F
F
S
A
------
24
PsiBlast_CBE
74.49
45%
-103
- C1 -
3R3U
1
DEHA_RHOPA
D:
[9-302]
-----
L
F
P
G
F
G
S
E
W
I
N
T
S
S
G
R
I
F
A
R
V
G
G
D
G
P
P
L
L
L
L
H
G
F
P
Q
T
H
V
M
W
H
R
V
A
P
K
L
A
E
R
F
K
V
I
V
A
D
L
P
G
Y
G
W
S
D
--
M
PE
S
D
E
Q
--
H
T
P
Y
T
K
R
A
M
A
K
Q
L
I
E
A
M
E
Q
L
G
H
V
H
F
A
L
A
G
H
D
R
G
A
R
V
S
Y
R
L
A
L
D
S
P
G
R
L
S
K
L
A
V
L
D
I
L
P
T
Y
E
Y
W
Q
R
M
N
R
A
Y
A
L
K
I
Y
H
W
S
F
L
A
Q
P
A
P
L
P
E
N
L
L
G
G
D
P
D
F
Y
V
K
A
K
L
A
S
W
-
T
R
A
-
G
D
L
SA
F
D
P
R
A
V
E
H
Y
R
I
A
F
A
D
P
M
R
R
H
V
M
C
E
D
Y
R
A
G
A
Y
A
D
F
E
H
D
K
I
D
V
E
A
G
N
K
I
P
V
P
M
L
A
L
W
G
A
S
G
I
A
Q
S
A
A
T
P
---
L
-
D
V
W
R
K
W
A
---
S
D
V
Q
G
A
P
I
E
S
G
H
F
L
P
E
E
A
P
D
Q
T
A
E
A
L
V
R
F
F
S
A
------
11
PsiBlast_PDB
74.46
45%
-101
- C1 -
3R40
5
DEHA_RHOPA
A:
[9-302]
-----
L
F
P
G
F
G
S
E
W
I
N
T
S
S
G
R
I
F
A
R
V
G
G
D
G
P
P
L
L
L
L
H
G
F
P
Q
T
H
V
M
W
H
R
V
A
P
K
L
A
E
R
F
K
V
I
V
A
D
L
P
G
Y
G
W
S
D
--
M
PE
S
D
E
Q
--
H
T
P
Y
T
K
R
A
M
A
K
Q
L
I
E
A
M
E
Q
L
G
H
V
H
F
A
L
A
G
H
N
R
G
A
R
V
S
Y
R
L
A
L
D
S
P
G
R
L
S
K
L
A
V
L
D
I
L
P
T
Y
E
Y
W
Q
R
M
N
R
A
Y
A
L
K
I
Y
H
W
S
F
L
A
Q
P
A
P
L
P
E
N
L
L
G
G
D
P
D
F
Y
V
K
A
K
L
A
S
W
-
T
R
A
-
G
D
L
SA
F
D
P
R
A
V
E
H
Y
R
I
A
F
A
D
P
M
R
R
H
V
M
C
E
D
Y
R
A
G
A
Y
A
D
F
E
H
D
K
I
D
V
E
A
G
N
K
I
P
V
P
M
L
A
L
W
G
A
S
G
I
------
P
---
L
-
D
V
W
R
K
W
A
---
S
D
V
Q
G
A
P
I
E
S
G
H
F
L
P
E
E
A
P
D
Q
T
A
E
A
L
V
R
F
F
S
A
------
29
PsiBlast_CBE
74.41
45%
-104
- C1 -
3R3W
2
DEHA_RHOPA
B:
[9-301]
-----
L
F
P
G
F
G
S
E
W
I
N
T
S
S
G
R
I
F
A
R
V
G
G
D
G
P
P
L
L
L
L
H
G
F
P
Q
T
H
V
M
W
H
R
V
A
P
K
L
A
E
R
F
K
V
I
V
A
D
L
P
G
Y
G
W
S
D
--
M
PE
S
D
E
Q
--
H
T
P
Y
T
K
R
A
M
A
K
Q
L
I
E
A
M
E
Q
L
G
H
V
H
F
A
L
A
G
H
N
R
G
A
R
V
S
Y
R
L
A
L
D
S
P
G
R
L
S
K
L
A
V
L
D
I
L
P
T
Y
E
Y
W
Q
R
M
N
R
A
Y
A
L
K
I
Y
H
W
S
F
L
A
Q
P
A
P
L
P
E
N
L
L
G
G
D
P
D
F
Y
V
K
A
K
L
A
S
W
-
T
R
A
-
G
D
L
SA
F
D
P
R
A
V
E
H
Y
R
I
A
F
A
D
P
M
R
R
H
V
M
C
E
D
Y
R
A
G
A
Y
A
D
F
E
H
D
K
I
D
V
E
A
G
N
K
I
P
V
P
M
L
A
L
W
G
--------
A
T
P
---
L
-
D
V
W
R
K
W
A
---
S
D
V
Q
G
A
P
I
E
S
G
H
F
L
P
E
E
A
P
D
Q
T
A
E
A
L
V
R
F
F
S
-------
21
PsiBlast_CBE
73.78
45%
-100
- C1 -
3R3Z
1
DEHA_RHOPA
D:
[9-302]
-----
L
F
P
G
F
G
S
E
W
I
N
T
S
S
G
R
I
F
A
R
V
G
G
D
G
P
P
L
L
L
L
H
G
F
P
Q
T
H
V
M
W
H
R
V
A
P
K
L
A
E
R
F
K
V
I
V
A
D
L
P
G
Y
G
W
S
D
--
M
PE
S
D
E
Q
--
H
T
P
Y
T
K
R
A
M
A
K
Q
L
I
E
A
M
E
Q
L
G
H
V
H
F
A
L
A
G
H
D
R
G
A
R
V
S
Y
R
L
A
L
D
S
P
G
R
L
S
K
L
A
V
L
D
I
L
P
T
Y
E
Y
W
Q
R
M
N
R
A
Y
A
L
K
I
Y
H
W
S
F
L
A
Q
P
A
P
L
P
E
N
L
L
G
G
D
P
D
F
Y
V
K
A
K
L
A
S
W
-
T
R
A
-
G
D
L
SA
F
D
P
R
A
V
E
H
Y
R
I
A
F
A
D
P
M
R
R
H
V
M
C
E
D
Y
R
A
G
A
Y
A
D
F
E
H
D
K
I
D
V
E
A
G
N
K
I
P
V
P
M
L
A
L
W
G
A
S
G
I
A
Q
S
A
A
T
P
---
L
-
D
V
W
R
K
W
A
---
S
D
V
Q
G
A
P
I
E
S
G
H
F
L
P
E
E
A
P
D
Q
T
A
E
A
L
V
R
F
F
S
A
------
33
PsiBlast_CBE
68.39
39%
-91
- C1 -
3B12
3
DEHA_BURSP
B:
[1-294]
-----
M
F
E
G
F
E
R
R
L
V
D
V
G
D
V
T
I
N
C
V
V
G
G
S
G
P
A
L
L
L
L
H
G
F
P
Q
N
L
H
M
W
A
R
V
A
P
L
L
A
N
E
Y
T
V
V
C
A
D
L
R
G
Y
G
G
S
S
KP
V
--
G
A
P
D
--
H
A
N
Y
S
F
R
A
M
A
S
D
Q
R
E
L
M
R
T
L
G
F
E
R
F
H
L
V
G
H
A
R
G
G
R
T
G
H
R
M
A
L
D
H
P
D
S
V
L
S
L
A
V
L
D
I
I
P
T
Y
V
M
F
E
E
V
D
R
F
V
A
R
A
Y
W
H
W
Y
F
L
Q
Q
P
A
P
Y
P
E
K
V
I
G
A
D
P
D
T
F
Y
E
G
C
L
F
G
W
G
A
T
G
-
A
D
G
--
F
D
P
E
Q
L
E
E
Y
R
K
Q
W
R
D
P
A
A
I
H
G
S
C
C
D
Y
R
A
G
G
T
I
D
F
E
L
D
H
G
--
D
L
G
R
Q
V
Q
C
P
A
L
V
F
S
G
S
---
A
-
G
L
M
H
S
---
L
F
E
M
Q
V
V
W
A
PRL
A
N
M
R
F
A
S
L
P
G
G
H
F
F
V
D
R
F
P
D
D
T
A
R
I
L
R
E
F
L
S
D
A
R
S
---
16
PsiBlast_PDB
68.13
39%
-91
- C1 -
3B12
2
DEHA_BURSP
A:
[1-294]
-----
M
F
E
G
F
E
R
R
L
V
D
V
G
D
V
T
I
N
C
V
V
G
G
S
G
P
A
L
L
L
L
H
G
F
P
Q
N
L
H
M
W
A
R
V
A
P
L
L
A
N
E
Y
T
V
V
C
A
D
L
R
G
Y
G
G
S
S
KP
V
--
G
A
P
D
--
H
A
N
Y
S
F
R
A
M
A
S
D
Q
R
E
L
M
R
T
L
G
F
E
R
F
H
L
V
G
H
A
R
G
G
R
T
G
H
R
M
A
L
D
H
P
D
S
V
L
S
L
A
V
L
D
I
I
P
T
Y
V
M
F
E
E
V
D
R
F
V
A
R
A
Y
W
H
W
Y
F
L
Q
Q
P
A
P
Y
P
E
K
V
I
G
A
D
P
D
T
F
Y
E
G
C
L
F
G
W
G
A
T
G
-
A
D
G
--
F
D
P
E
Q
L
E
E
Y
R
K
Q
W
R
D
P
A
A
I
H
G
S
C
C
D
Y
R
A
G
G
T
I
D
F
E
L
D
H
G
--
D
L
G
R
Q
V
Q
C
P
A
L
V
F
S
G
S
---
A
-
G
L
M
H
S
---
L
F
E
M
Q
V
V
W
A
PRL
A
N
M
R
F
A
S
L
P
G
G
H
F
F
V
D
R
F
P
D
D
T
A
R
I
L
R
E
F
L
S
D
A
R
S
---
49
HHSearch
66.85
39%
-89
* C1 *
3B12
2
DEHA_BURSP
A:
[4-294]
--------
G
F
E
R
R
L
V
D
V
G
D
V
T
I
N
C
V
V
G
G
S
G
P
A
L
L
L
L
H
G
F
P
Q
N
L
H
M
W
A
R
V
A
P
L
L
A
N
E
Y
T
V
V
C
A
D
L
R
G
Y
G
G
S
S
--
K
--
P
V
G
A
PD
H
A
N
Y
S
F
R
A
M
A
S
D
Q
R
E
L
M
R
T
L
G
F
E
R
F
H
L
V
G
H
A
R
G
G
R
T
G
H
R
M
A
L
D
H
P
D
S
V
L
S
L
A
V
L
D
I
I
P
T
Y
V
M
F
E
E
V
D
R
F
V
A
R
A
Y
W
H
W
Y
F
L
Q
Q
P
A
P
Y
P
E
K
V
I
G
A
D
P
D
T
F
Y
E
G
C
L
F
G
W
-
G
A
T
G
A
D
G
--
F
D
P
E
Q
L
E
E
Y
R
K
Q
W
R
D
P
A
A
I
H
G
S
C
C
D
Y
R
A
G
G
T
I
D
F
E
L
D
--
H
G
D
L
G
R
Q
V
Q
C
P
A
L
V
F
S
--
G
S
A
G
-
L
M
H
S
L
F
E
M
Q
-
V
V
W
A
P
R
L
---
A
N
M
R
F
A
S
L
P
G
G
H
F
F
V
D
R
F
P
D
D
T
A
R
I
L
R
E
F
L
S
D
A
R
S
---