@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2108: (2016-02-04 )
MSSTVADQLLERLSQWGVKRVFGYPGDGINGIMGAMGRRAEAFDYIRVRHEEMAAFMAGAHAKFTGEVGVCLATSGPGAIHLLNGLYDARMDHQPVLAIVGQQAATALGSDYQQEVDLQSLFKDVSAYVETVVSPAQLLHVLDRALRVAVGERQVATVIVPNDVQQMAAPKRQPHEHGHVMSAVGFVQPRPYARDADLEAAAAILNRGRRVAILAGAGALGAHRQLEAVAERLAAGVAKALLGKAAVSDDLPYVTGSIGLLGTRASSMLMEHCDTLLIVGSTFPYSEFLPKAGQARAVQIDLYPRNIGIRYPIDQALLGDAGETLERLLPLLEQKKHGAWRRRVERAVTASREEARRQAEEPADPINPQRVFRSLSEQLPDDAILCGDSGSHTNWYARDIRMRPGMLGSLSGKLATMGSGVPYAIAAKLAYPQRPVVAMVGDGAMQMNGNAELVTVQQYWQRWDSPTFIVLVLNNGDLNQVTWEQRALAGDPEFSPAQEVIDFPYARYADMLGFKGIRVDRPEDIDAAWAEAFAADRPVLLEVVTDPNVPPLPPHISFEQAKHLLGAMLQDDPKRWGVIRQSARQVLARH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150....-...160.......170.......180.......190.......200..---.....210.......220.......230.......240.......250.......260.......270.......280.......290.....-..300.......310.......320.......330.......340.......350.......360...----....370.......380.......390.......400--.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......--530.......540.......550.......560.......570.......580.......590
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
S
T
V
A
D
Q
L
L
E
R
L
S
QWG
V
K
R
VFGYPGD
G
I
N
G
I
M
G
AMGRR
A
E
A
F
D
Y
I
R
V
R
H
E
E
M
A
A
F
M
AGAH
A
K
F
TGE
V
G
V
C
L
ATSGP
G
A
I
H
L
L
N
G
L
Y
DARMDHQ
P
V
L
A
I
V
G
Q
Q
A
A
T
A
LG
S
D
Y
Q
Q
EV
D
L
Q
S
L
F
K
D
V
S
A
Y
V
E
T
VV
S
P
A
Q
L
L
H
V
L
D
R
A
L
R
V
AVGE
R
Q
V
A
-
T
V
IVPN
D
V
Q
Q
MAAPKRQPHEHGH
V
M
S
AVGFVQPRPYARDA
D
L
E
A
A
A
A
I
---
L
NRG
R
R
V
A
I
L
AGAGALG
A
H
R
Q
L
E
A
V
A
E
R
L
A
A
G
V
A
K
A
L
L
GKAAVSDDLPYVTGSIGLLG
T
R
A
S
S
M
L
M
E
HCD
T
L
L
I
VGSTF
P
Y
S
E
FLPKAGQ
A
R
A
-
V
Q
I
D
L
Y
PRNIGIRYPI
D
Q
A
L
LG
D
A
G
E
T
L
E
R
L
L
P
L
L
E
QKKH
G
A
W
R
R
R
V
E
R
A
V
TA
S
R
E
E
A
R
R
Q
AEEPADP----I
N
P
Q
R
V
F
R
S
L
S
E
QLPD
D
A
I
L
CGDSGSHT
N
W
Y
A
R
DIRM--RPGMLGSLSG
K
L
A
TMGSGV
P
Y
A
I
A
A
KLAYPQR
P
V
V
A
M
VGD
G
A
M
Q
MNGNA
E
L
V
T
V
Q
Q
Y
W
Q
RWDS
P
T
F
I
V
L
V
LNNGDL
N
Q
V
T
W
E
Q
RALAGDPEFS
P
A
Q
E
V
IDF
P
Y
A
R
Y
A
D
M
LGFKGIRVDRPEDI
D
A
A
W
--
A
E
A
FAADR
P
V
L
L
E
V
VTDPNVPPLPPHI
S
F
E
Q
A
K
H
L
L
G
A
M
L
QD
D
P
K
R
W
G
V
I
R
Q
S
A
R
Q
V
L
ARH
22
PsiBlast_CBE
94.34
37%
-102
- C5 -
3EYA
41
POXB_ECOLI
L:
[1-535]
M
K
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
N
R
M
G
-
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
G
V
S
-
V
V
V
L
P
G
D
V
A
L
K
P
A
P
E
------
G
A
T
M
H
W
Y
H
A
P
Q
P
V
V
T
P
E
E
E
E
L
R
K
L
A
Q
L
---
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
G
L
I
G
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
A
F
Y
P
T
--
D
A
K
I
-
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
E
K
---
A
D
R
K
F
L
D
K
A
L
E
D
Y
R
-
D
A
R
K
G
L
D
D
L
A
K
P
SEKA
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
NG
K
R
R
L
L
G
S
F
N
H
--
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
-----
P
V
K
I
V
-
V
F
N
N
S
V
L
G
F
V
---------------
G
T
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
--
Q
R
A
F
S
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
-------------------------------------
1
PsiBlast_PDB
94.22
37%
-97
- C5 -
3EY9
6
POXB_ECOLI
A:
[2-552]
-
K
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
N
R
M
G
-
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
G
V
S
-
V
V
V
L
P
G
D
V
A
L
K
P
A
P
E
------
G
A
T
M
H
W
Y
H
A
P
Q
P
V
V
T
P
E
E
E
E
L
R
K
L
A
Q
L
---
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
G
L
I
G
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
A
F
Y
P
T
--
D
A
K
I
-
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
E
K
---
A
D
R
K
F
L
D
K
A
L
E
D
Y
R
-
D
A
R
K
G
L
D
D
L
A
K
P
SEKA
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
N
G
K
R
R
L
L
G
S
F
N
H
--
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
-----
P
V
K
I
V
-
V
F
N
N
S
V
L
G
F
V
A
M
E
M
K
A
---
G
G
Y
L
T
D
G
T
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
--
Q
R
A
F
S
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
P
Q
I
K
L
E
Q
A
K
G
F
S
L
Y
M
L
R
A
I
I
S
G
R
G
D
E
V
I
E
L
A
K
T
N
W
L
R
21
PsiBlast_CBE
94.14
37%
-97
- C5 -
3EY9
6
POXB_ECOLI
B:
[2-552]
-
K
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
N
R
M
G
-
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
G
V
S
-
V
V
V
L
P
G
D
V
A
L
K
P
A
P
E
------
G
A
T
M
H
W
Y
H
A
P
Q
P
V
V
T
P
E
E
E
E
L
R
K
L
A
Q
L
---
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
G
L
I
G
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
A
F
Y
P
T
--
D
A
K
I
-
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
E
K
---
A
D
R
K
F
L
D
K
A
L
E
D
Y
R
-
D
A
R
K
G
L
D
D
L
A
K
P
SEKA
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
NG
K
R
R
L
L
G
S
F
N
H
--
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
-----
P
V
K
I
V
-
V
F
N
N
S
V
L
G
F
V
A
M
E
M
K
A
---
G
G
Y
L
T
D
G
T
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
--
Q
R
A
F
S
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
P
Q
I
K
L
E
Q
A
K
G
F
S
L
Y
M
L
R
A
I
I
S
G
R
G
D
E
V
I
E
L
A
K
T
N
W
L
R
23
PsiBlast_CBE
94.13
37%
-101
- C5 -
3EYA
41
POXB_ECOLI
K:
[1-535]
M
K
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
N
R
M
G
-
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
G
V
S
-
V
V
V
L
P
G
D
V
A
L
K
P
A
P
E
------
G
A
T
M
H
W
Y
H
A
P
Q
P
V
V
T
P
E
E
E
E
L
R
K
L
A
Q
L
---
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
G
L
I
G
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
A
F
Y
P
T
--
D
A
K
I
-
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
E
K
---
A
D
R
K
F
L
D
K
A
L
E
D
Y
R
-
D
A
R
K
G
L
D
D
L
A
K
P
SEKA
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
NG
K
R
R
L
L
G
S
F
N
H
--
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
-----
P
V
K
I
V
-
V
F
N
N
S
V
L
G
F
---------------
D
G
T
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
--
Q
R
A
F
S
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
-------------------------------------
32
PsiBlast_CBE
93.98
37%
-101
- C5 -
3EYA
7
POXB_ECOLI
B:
[1-535]
M
K
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
N
R
M
G
-
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
G
V
S
-
V
V
V
L
P
G
D
V
A
L
K
P
A
P
E
------
G
A
T
M
H
W
Y
H
A
P
Q
P
V
V
T
P
E
E
E
E
L
R
K
L
A
Q
L
---
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
G
L
I
G
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
A
F
Y
P
T
--
D
A
K
I
-
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
E
K
---
A
D
R
K
F
L
D
K
A
L
E
D
Y
R
-
D
A
R
K
G
L
D
D
L
A
K
P
SEKA
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
NG
K
R
R
L
L
G
S
F
N
H
--
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
-----
P
V
K
I
V
-
V
F
N
N
S
V
L
G
F
V
--------------
D
G
T
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
--
Q
R
A
F
S
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
-------------------------------------
30
PsiBlast_CBE
93.95
37%
-101
- C5 -
3EYA
1
POXB_ECOLI
D:
[2-533]
-
K
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
N
R
M
G
-
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
G
V
S
-
V
V
V
L
P
G
D
V
A
L
K
P
A
P
E
------
G
A
T
M
H
W
Y
H
A
P
Q
P
V
V
T
P
E
E
E
E
L
R
K
L
A
Q
L
---
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
G
L
I
G
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
A
F
Y
P
T
--
D
A
K
I
-
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
E
K
---
A
D
R
K
F
L
D
K
A
L
E
D
Y
R
-
D
A
R
K
G
L
D
D
L
A
K
P
SEKA
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
NG
K
R
R
L
L
G
S
F
N
H
--
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
-----
P
V
K
I
V
-
V
F
N
N
S
V
L
G
F
V
---------------
G
T
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
--
Q
R
A
F
S
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
---------------------------------------
2
PsiBlast_PDB
93.86
37%
-100
- C5 -
3EYA
11
POXB_ECOLI
A:
[1-539]
M
K
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
N
R
M
G
-
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
G
V
S
-
V
V
V
L
P
G
D
V
A
L
K
P
A
P
E
------
G
A
T
M
H
W
Y
H
A
P
Q
P
V
V
T
P
E
E
E
E
L
R
K
L
A
Q
L
---
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
G
L
I
G
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
A
F
Y
P
T
--
D
A
K
I
-
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
E
K
---
A
D
R
K
F
L
D
K
A
L
E
D
Y
R
-
D
A
R
K
G
L
D
D
L
A
K
P
SEKA
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
N
G
K
R
R
L
L
G
S
F
N
H
--
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
-----
P
V
K
I
V
-
V
F
N
N
S
V
L
G
F
V
---------------
G
T
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
--
Q
R
A
F
S
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
P
Q
I
K
---------------------------------
57
HHSearch
90.56
36%
-97
- C5 -
3EYA
11
POXB_ECOLI
A:
[1-539]
M
K
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
N
R
M
-
G
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
-
R
G
V
S
V
V
V
L
P
G
D
V
A
L
K
P
A
P
E
G
A
T
-
M
H
W
Y
H
A
-
P
Q
P
V
V
T
P
E
----
E
E
E
L
R
K
L
A
Q
L
---
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
G
L
I
G
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
A
F
Y
P
--
T
D
A
K
I
-
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
E
K
A
D
R
K
F
L
D
K
A
L
E
D
Y
R
D
A
R
K
G
L
D
D
L
A
K
P
S
E
K
A
----
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
--
N
G
K
R
R
L
L
G
S
F
N
H
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
-
M
G
D
F
L
S
V
V
Q
M
K
L
-----
P
V
K
I
V
V
F
N
N
S
V
L
G
F
V
-------------
G
--
T
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
--
Q
R
A
F
S
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
P
Q
I
K
---------------------------------
3
PsiBlast_PDB
89.62
31%
-96
- C5 -
1POX
5
POXB_LACPL
A:
[9-541]
--------
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
-
V
V
Q
I
P
V
D
L
-----
P
W
Q
Q
I
S
A
E
D
W
Y
A
S
A
N
N
Y
--
Q
T
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
E
V
S
K
A
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
----
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
--
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
-
D
L
V
T
Q
V
Q
Y
-----
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
-
T
N
Q
N
D
F
I
-
G
V
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
A
Q
D
L
Q
P
L
S
T
Y
L
K
Q
F
43
PsiBlast_CBE
89.22
31%
-100
- C5 -
1Y9D
7
POXB_LACPL
D:
[17-549]
--------
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
-------
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
-
V
V
Q
I
P
V
D
L
-----
P
W
Q
Q
I
P
A
E
D
W
Y
A
S
A
----------
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
A
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
----------
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
----
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
--
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
-
D
L
A
T
Q
V
Q
Y
-----
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
-
T
N
Q
N
D
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
A
Q
D
L
Q
P
L
S
T
Y
L
K
Q
F
44
PsiBlast_CBE
88.95
31%
-100
- C5 -
1Y9D
7
POXB_LACPL
C:
[17-549]
--------
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
-------
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
-
V
V
Q
I
P
V
D
L
-----
P
W
Q
Q
I
P
A
E
---------------
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
A
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
---------
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
----
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
--
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
-
D
L
A
T
Q
V
Q
Y
-----
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
-
T
N
Q
N
D
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
A
Q
D
L
Q
P
L
S
T
Y
L
K
Q
F
45
PsiBlast_CBE
88.70
31%
-99
- C5 -
1Y9D
7
POXB_LACPL
B:
[17-549]
--------
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
-----
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
-
V
V
Q
I
P
V
D
L
-----
P
W
Q
Q
I
P
A
E
D
W
Y
--------
Q
T
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
A
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
------
A
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
----
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
--
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
-
D
L
A
T
Q
V
Q
Y
-----
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
-
T
N
Q
N
D
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
A
Q
D
L
Q
P
L
S
T
Y
L
K
Q
F
8
PsiBlast_PDB
88.32
31%
-94
- C5 -
2EZU
4
POXB_LACPL
A:
[17-549]
--------
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
-
V
V
Q
I
P
V
D
L
-----
P
W
Q
Q
I
P
A
E
D
W
Y
A
S
A
N
S
Y
--
Q
T
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
E
V
S
K
A
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
----
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
--
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
-
D
L
A
T
Q
V
Q
Y
-----
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
-
T
N
Q
N
D
F
I
-
G
V
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
A
Q
D
L
Q
P
L
S
T
Y
L
K
Q
F
5
PsiBlast_PDB
88.19
31%
-94
- C5 -
2EZ8
4
POXB_LACPL
A:
[17-549]
--------
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
-
V
V
Q
I
P
V
D
L
-----
P
W
Q
Q
I
P
A
E
D
W
Y
A
S
A
N
S
Y
--
Q
T
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
E
V
S
K
A
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
----
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
--
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
-
D
L
A
T
Q
V
Q
Y
-----
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
-
T
N
Q
N
D
F
I
-
G
V
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
A
Q
D
L
Q
P
L
S
T
Y
L
K
Q
F
33
PsiBlast_CBE
88.16
31%
-96
- C5 -
1POX
5
POXB_LACPL
B:
[9-541]
--------
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
-
V
V
Q
I
P
V
D
L
-----
P
W
Q
Q
I
S
A
E
D
W
Y
A
S
A
N
N
Y
--
Q
T
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
TQT
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
E
V
S
K
A
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
----
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
--
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
-
D
L
V
T
Q
V
Q
Y
-----
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
-
T
N
Q
N
D
F
I
-
G
V
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
EQ
A
K
A
I
A
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
A
Q
D
L
Q
P
L
S
T
Y
L
K
Q
F
4
PsiBlast_PDB
87.94
31%
-93
- C5 -
2EZ4
5
POXB_LACPL
A:
[17-549]
--------
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
-
V
V
Q
I
P
V
D
L
-----
P
W
Q
Q
I
P
A
E
D
W
Y
A
S
A
N
S
Y
--
Q
T
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
E
V
S
K
A
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
----
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
--
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
-
D
L
A
T
Q
V
Q
Y
-----
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
-
T
N
Q
N
D
F
I
-
G
V
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
A
Q
D
L
Q
P
L
S
T
Y
L
K
Q
F
6
PsiBlast_PDB
87.88
31%
-94
- C5 -
2EZ9
4
POXB_LACPL
A:
[17-549]
--------
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
-
V
V
Q
I
P
V
D
L
-----
P
W
Q
Q
I
P
A
E
D
W
Y
A
S
A
N
S
Y
--
Q
T
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
E
V
S
K
A
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
----
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
--
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
-
D
L
A
T
Q
V
Q
Y
-----
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
-
T
N
Q
N
D
F
I
-
G
V
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
A
Q
D
L
Q
P
L
S
T
Y
L
K
Q
F
38
PsiBlast_CBE
87.85
31%
-95
- C5 -
2EZ4
5
POXB_LACPL
B:
[17-549]
--------
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
-
V
V
Q
I
P
V
D
L
-----
P
W
Q
Q
I
P
A
E
D
W
Y
A
S
A
N
S
Y
--
Q
T
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
TQT
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
E
V
S
K
A
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
----
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
--
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
-
D
L
A
T
Q
V
Q
Y
-----
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
-
T
N
Q
N
D
F
I
-
G
V
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
EQ
A
K
A
I
A
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
A
Q
D
L
Q
P
L
S
T
Y
L
K
Q
F
13
PsiBlast_PDB
87.77
31%
-97
- C5 -
1Y9D
7
POXB_LACPL
A:
[17-549]
--------
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
-------
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
-
V
V
Q
I
P
V
D
L
-----
P
W
Q
Q
I
P
A
E
D
W
-----------
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
A
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
-----------
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
----
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
--
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
-
D
L
A
T
Q
V
Q
Y
-----
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
-
T
N
Q
N
D
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
A
Q
D
L
Q
P
L
S
T
Y
L
K
Q
F
9
PsiBlast_PDB
87.75
31%
-96
- C5 -
1POW
3
POXB_LACPL
A:
[9-541]
--------
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
-
V
V
Q
I
P
V
D
L
-----
P
W
Q
Q
I
P
A
E
D
W
Y
A
S
A
N
S
Y
--
Q
T
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
E
V
S
K
A
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
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A
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K
T
L
A
A
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L
A
Q
V
S
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R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
----
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
--
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
-
D
L
A
T
Q
V
Q
Y
-----
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
-
T
N
Q
N
D
F
I
-
G
V
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F
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D
I
D
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A
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M
Q
A
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V
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K
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A
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A
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L
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L
P
A
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L
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L
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A
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A
A
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A
F
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Q
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Y
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A
Q
D
L
Q
P
L
S
T
Y
L
K
Q
F