@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2382: (2016-02-07 )
MSVITDIEDLRRLARKRVPRMFYDYADSGSWSEGTYRANQDDFAAIKLRQRVARNIENRSLRTRMLGQEMAMPVAIAPTGLAGMQHADGEILAARAAAEFGVRYTLSTMSICSLEDIATEVGQPFWFQLYVMRDRDFIERLIDRAKAAGCDALVLTLDLQIIGQRHKDLKNGLSAPPRPTLANLLNIATKPRWALGMLGTRRRGFGNIVGHVKGVDDMGSLSEWTARQFDPRLNWGDVEWIKRRWGGKLVLKGILDAEDARLAADSGADALVVSNHGGRQLDGAPSTISALPAIVEAVGERIEVWLDSGIRSGQDVLKAIALGARGTMIGRPYLYGLGALGQAGVTRALEIIARELDLTMAFCGHTDIREVGRDILLPGSYPR
Atome Classification :
(36 SA)
.........10........20........30........40........50........60........70........80......-..90........--100.......110.....---..120.---...-....130.......140.......150.......160.......170.......180..--.....190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......-----300----........310.......320.......330.......340.......350.......360.......370.......380.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSVIT
D
I
E
D
L
R
R
L
A
R
K
R
V
P
R
M
F
Y
DYADSGSWSEGTYRANQD
D
F
A
A
I
K
L
R
Q
R
V
A
R
N
I
EN
R
S
L
R
T
R
ML
G
Q
EMAM
P
V
A
IAPTGLAGMQHA-DGE
I
L
A
A
R
A
A
A
E--FG
V
R
Y
T
L
STMSIC
S
L
E
D
I
---
A
T
EV-G---Q
P
F
-
W
F
Q
L
Y
V
MR
D
R
D
F
I
E
R
L
I
D
R
A
KAAGC
D
A
L
V
L
T
L
D
L
Q
I
I
G
Q
R
H
K
D
L
K
NGLSAPPR
P
T
L
A
N
L
--
L
N
IATKP
R
W
ALGMLGTRRRG
F
G
N
I
V
GHVKGVDDMG
S
L
S
E
W
T
A
R
QFDPRLNWG
D
V
E
W
I
K
R
RWG
G
K
L
V
L
K
G
ILDA
E
D
A
R
LAADSGA
D
A
L
V
V
SNHGGRQLDGAP
S
T
I
S
A
L
P
A
I
V
E
A
V
G
-----
E
R
-----
I
E
V
W
L
D
SGIR
S
G
Q
D
V
L
K
A
I
ALGARGTMIGR
P
Y
L
Y
GLGAL
G
Q
A
G
V
T
R
A
L
E
I
I
A
R
EL
D
L
T
M
A
FCGHT
D
I
R
E
VGR
D
I
LLPGSYPR
136
HHSearch
96.55
39%
-96
- C2 -
1GOX
2
GOX_SPIOL
A:
[1-356]
-
M
E
I
T
N
V
N
E
Y
E
A
I
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
K
M
A
H
P
-
E
G
E
Y
A
T
A
R
A
A
S
A
--
A
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
---
A
S
T
G
-
P
---
G
I
R
-
F
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
T
P
R
L
G
R
R
E
A
D
I
K
N
R
F
V
L
P
P
F
L
T
L
K
N
F
--
E
G
I
D
L
G
---------------------------
L
---
S
S
Y
V
A
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
V
K
A
A
Q
-----
G
R
-----
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
R
S
H
I
A
A
-----
1
PsiBlast_PDB
94.66
38%
-96
- C2 -
1GOX
1
GOX_SPIOL
A:
[3-351]
---
I
T
N
V
N
E
Y
E
A
I
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
K
M
A
H
P
-
E
G
E
Y
A
T
A
R
A
A
S
A
--
A
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
---
A
S
T
G
-
P
---
G
I
R
-
F
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
T
P
R
L
G
R
R
E
A
D
I
K
N
R
F
V
L
P
P
F
L
T
L
K
N
F
--
E
G
I
D
--------------------
L
G
----------
L
S
S
Y
V
A
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
V
K
A
A
Q
-----
G
R
-----
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
R
----------
5
PsiBlast_PDB
94.24
35%
-100
- C2 -
2RDU
2
HAOX1_HUMAN
A:
[25-377]
------
I
N
D
Y
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
A
H
V
-
D
G
E
L
A
T
V
R
A
C
Q
S
--
L
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
---
A
E
A
G
-
P
---
E
A
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
N
R
F
K
L
P
P
Q
L
R
M
K
N
F
ET
S
T
L
S
F
S
P
E
E
N
F
G
-------------------
D
D
S
G
-
L
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
E
-----
G
K
-----
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
K
T
L
V
-------
2
PsiBlast_PDB
94.10
38%
-96
- C2 -
1AL7
2
GOX_SPIOL
A:
[3-351]
---
I
T
N
V
N
E
Y
E
A
I
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
K
M
A
H
P
-
E
G
E
Y
A
T
A
R
A
A
S
A
--
A
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
---
A
S
T
G
-
P
---
G
I
R
-
F
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
T
P
R
L
G
R
R
E
A
D
I
K
N
R
F
V
L
P
P
F
L
T
L
K
N
F
--
E
G
I
D
--------------------
L
G
----------
L
S
S
Y
V
A
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
V
K
A
A
Q
-----
G
R
-----
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
R
----------
6
PsiBlast_PDB
93.95
35%
-100
- C2 -
2RDW
2
HAOX1_HUMAN
A:
[25-377]
------
I
N
D
Y
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
A
H
V
-
D
G
E
L
A
T
V
R
A
C
Q
S
--
L
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
---
A
E
A
G
-
P
---
E
A
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
N
R
F
K
L
P
P
Q
L
R
M
K
N
F
ET
S
T
L
S
F
S
P
E
E
N
F
G
-------------------
D
D
S
G
-
L
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
E
-----
G
K
-----
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
K
T
L
V
-------
135
HHSearch
93.62
37%
-98
- C2 -
1P4C
3
GOX_SPIOL
A:
[4-356]
--
N
L
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
G
A
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
---
A
R
Q
C
-
D
---
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
I
P
P
F
L
T
L
K
N
F
--
E
G
I
D
L
G
----------
K
M
D
K
A
N
L
E
M
Q
A
-----------
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
-------
G
-----
K
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
Q
N
E
----
14
PsiBlast_PDB
92.95
36%
-100
- C2 -
3GIY
2
MDLB_PSEPU
A:
[5-353]
---
L
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
---
A
R
Q
C
-
D
---
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
I
P
P
F
L
T
L
K
N
F
--
E
G
I
D
---------
L
G
K
M
D
K
A
------------
N
L
E
M
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
G
-----
K
-------
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
-------
11
PsiBlast_PDB
92.86
36%
-100
- C2 -
2A7N
2
GOX_SPIOL
A:
[5-353]
---
L
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
---
A
R
Q
C
-
D
---
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
I
P
P
F
L
T
L
K
N
F
--
E
G
I
D
---------
L
G
K
M
D
K
A
------------
N
L
E
M
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
G
-----
K
-------
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
-------
3
PsiBlast_PDB
92.84
38%
-104
- C2 -
1AL8
2
GOX_SPIOL
A:
[3-351]
---
I
T
N
V
N
E
Y
E
A
I
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
K
M
A
H
P
-
E
G
E
Y
A
T
A
R
A
A
S
A
--
A
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
---
A
S
T
G
-
P
---
G
I
R
-
F
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
T
P
R
L
------
I
K
N
R
F
V
L
P
P
F
L
T
L
K
N
F
--
E
G
I
D
--------------------
L
G
----------
L
S
S
Y
V
A
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
V
K
A
A
Q
-----
G
R
-----
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
R
----------
9
PsiBlast_PDB
92.83
36%
-98
- C2 -
1P4C
3
GOX_SPIOL
A:
[5-353]
---
L
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
G
A
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
---
A
R
Q
C
-
D
---
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
I
P
P
F
L
T
L
K
N
F
--
E
G
I
D
---------
L
G
K
M
D
K
A
------------
N
L
E
M
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
G
-----
K
-------
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
-------
12
PsiBlast_PDB
92.57
36%
-100
- C2 -
2A7P
3
GOX_SPIOL (first)
A:
[5-353]
---
L
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
---
A
R
Q
C
-
D
---
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
I
P
P
F
L
T
L
K
N
F
--
E
G
I
D
---------
L
G
K
M
D
K
A
------------
N
L
E
M
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
G
-----
K
-------
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
-------
10
PsiBlast_PDB
92.48
36%
-99
- C2 -
1P5B
3
GOX_SPIOL (first)
A:
[5-353]
---
L
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
G
A
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
---
A
R
Q
C
-
D
---
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
I
P
P
F
L
T
L
K
N
F
--
E
G
I
D
---------
L
G
K
M
D
K
A
------------
N
L
E
M
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
G
-----
K
-------
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
-------
8
PsiBlast_PDB
92.23
36%
-103
- C2 -
1HUV
3
GOX_SPIOL (first)
A:
[5-353]
---
L
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
G
A
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
---
A
R
Q
C
-
D
---
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
I
P
P
F
L
T
L
K
N
F
--
E
G
I
D
---------
L
G
K
M
D
----------------
E
M
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
G
-----
K
-------
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
-------
7
PsiBlast_PDB
92.21
35%
-105
- C2 -
2W0U
2
HAOX1_HUMAN
A:
[8-360]
------
I
N
D
Y
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
A
H
V
-
D
G
E
L
A
T
V
R
A
C
Q
S
--
L
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
---
A
E
A
G
-
P
---
E
A
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
N
R
F
K
L
P
--------------------------------------------
G
-
L
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
E
-----
G
K
-----
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
K
T
L
V
-------
21
PsiBlast_CBE
92.19
35%
-106
- C2 -
2W0U
2
HAOX1_HUMAN
D:
[8-360]
------
I
N
D
Y
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
A
H
V
-
D
G
E
L
A
T
V
R
A
C
Q
S
--
L
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
---
A
E
A
G
-
P
---
E
A
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
N
R
F
K
L
---------------------------------------------
G
-
L
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
E
-----
G
K
-----
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
K
T
L
V
-------
13
PsiBlast_PDB
92.00
36%
-96
- C2 -
2A85
3
GOX_SPIOL
A:
[5-353]
---
L
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
---
A
R
Q
C
-
D
---
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
I
P
P
F
L
T
L
K
N
F
--
E
G
I
D
---------
L
G
K
M
D
K
A
------------
N
L
E
M
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
G
-----
K
-------
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
-------
23
PsiBlast_CBE
91.99
35%
-105
- C2 -
2W0U
2
HAOX1_HUMAN
B:
[8-360]
------
I
N
D
Y
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
A
H
V
-
D
G
E
L
A
T
V
R
A
C
Q
S
--
L
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
---
A
E
A
G
-
P
---
E
A
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
N
R
F
K
L
---------------------------------------------
G
-
L
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
E
-----
G
K
-----
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
K
T
L
V
-------
4
PsiBlast_PDB
91.95
35%
-106
- C2 -
2RDT
2
HAOX1_HUMAN
A:
[25-377]
------
I
N
D
Y
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
A
H
V
-
D
G
E
L
A
T
V
R
A
C
Q
S
--
L
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
---
A
E
A
G
-
P
---
E
A
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
N
R
F
-------------------------------------------------
L
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
E
-----
G
K
-----
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
K
T
L
V
-------
49
PsiBlast_CBE
90.81
31%
-90
- C2 -
4YL2
2
?
A:
[19-360]
---
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
K
E
A
G
T
A
R
A
V
S
E
--
F
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
---
S
E
G
L
N
G
---
G
P
R
-
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
F
P
--------------------
F
G
M
P
I
V
Q
R
Y
----
L
R
G
T
A
E
G
M
S
-
L
N
N
I
Y
G
A
S
K
Q
K
I
S
P
R
----
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
------------
53
PsiBlast_CBE
90.64
31%
-90
- C2 -
2J6X
1
?
C:
[19-360]
---
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
K
E
A
G
T
A
R
A
V
S
E
--
F
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
---
S
E
G
L
N
G
---
G
P
R
-
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--------------------
F
G
M
P
I
V
Q
R
Y
----
L
R
G
T
A
E
G
M
S
-
L
N
N
I
Y
G
A
S
K
Q
K
I
S
P
R
----
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
------------
139
HHSearch
90.11
32%
-100
- C2 -
1KBI
6
CYB2_YEAST
A:
[120-481]
-
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
G
E
K
D
V
A
R
G
C
G
Q
GV
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
---
I
E
A
A
-
P
SDK
Q
I
Q
-
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
N
T
-----------------------------
K
K
T
N
V
E
E
---
S
Q
G
A
S
-
R
---
A
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
RNLK
D
K
-----
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
D
L
L
D
L
S
----
36
PsiBlast_CBE
88.75
31%
-99
- C2 -
1KBI
3
CYB2_YEAST
B:
[122-478]
---
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
G
E
K
D
V
A
R
G
C
G
Q
GV
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
S
D
-
K
---
Q
I
Q
-
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
-------------
N
T
-----------
K
T
-------------
N
V
E
E
S
Q
G
A
S
R
A
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
D
L
L
-------
37
PsiBlast_CBE
88.68
31%
-100
- C2 -
1KBI
6
CYB2_YEAST
A:
[122-478]
---
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
G
E
K
D
V
A
R
G
C
G
Q
GV
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
S
D
-
K
---
Q
I
Q
-
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
-------------
N
T
----------
K
K
T
-------------
N
V
E
E
S
Q
G
A
S
R
A
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
D
L
L
-------
138
HHSearch
88.40
32%
-96
- C2 -
2NLI
3
?
A:
[10-362]
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
K
E
A
G
T
A
R
A
V
S
E
--
F
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
---
S
E
G
L
N
G
---
G
P
R
-
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
---
N
R
D
--------
Y
P
F
G
M
P
I
V
Q
----
R
Y
L
R
----------
G
-------
T
A
E
----
G
M
---------
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
----
40
PsiBlast_CBE
87.79
31%
-99
- C2 -
1KBJ
2
CYB2_YEAST
A:
[23-379]
---
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
G
E
K
D
V
A
R
G
C
G
Q
GV
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
S
D
-
K
---
Q
I
Q
-
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
------------------------------------------------
A
S
R
A
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
D
L
L
-------
38
PsiBlast_CBE
87.63
31%
-100
- C2 -
1FCB
2
CYB2_YEAST
B:
[122-478]
---
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
G
E
K
D
V
A
R
G
C
G
Q
GV
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
S
D
-
K
---
Q
I
Q
-
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
-----------------------------------------
N
V
E
E
S
Q
G
A
S
R
A
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
D
L
L
-------
17
PsiBlast_PDB
87.52
31%
-97
- C2 -
1SZF
2
CYB2_YEAST
A:
[122-478]
---
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
G
L
C
K
L
G
N
P
L
E
G
E
K
D
V
A
R
G
C
G
Q
GV
T
K
V
P
Q
M
I
S
T
A
A
S
C
S
P
E
E
I
I
E
A
A
P
S
D
-
K
---
Q
I
Q
-
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
-------------
N
---------------------------------
G
A
S
R
A
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
D
L
L
-------
34
PsiBlast_CBE
87.36
31%
-98
- C2 -
1SZF
2
CYB2_YEAST
B:
[122-478]
---
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
G
L
C
K
L
G
N
P
L
E
G
E
K
D
V
A
R
G
C
G
Q
GV
T
K
V
P
Q
M
I
S
T
A
A
S
C
S
P
E
E
I
I
E
A
A
P
S
D
-
K
---
Q
I
Q
-
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
----------------------------------------------------
A
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
D
L
L
-------
39
PsiBlast_CBE
87.17
31%
-99
- C2 -
1KBJ
2
CYB2_YEAST
B:
[23-379]
---
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
G
E
K
D
V
A
R
G
C
G
Q
GV
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
S
D
-
K
---
Q
I
Q
-
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
-------------------------------------------------
A
S
R
A
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
D
L
L
-------
42
PsiBlast_CBE
86.93
31%
-97
- C2 -
1SZE
2
CYB2_YEAST
A:
[122-478]
---
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
G
E
K
D
V
A
R
G
C
G
Q
GV
T
K
V
P
Q
M
I
S
T
A
A
S
C
S
P
E
E
I
I
E
A
A
P
S
D
-
K
---
Q
I
Q
-
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
-------------------------------------------------
A
S
R
A
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
D
L
L
-------
20
PsiBlast_PDB
86.61
31%
-100
- C2 -
1FCB
2
CYB2_YEAST
A:
[122-478]
---
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
G
E
K
D
V
A
R
G
C
G
Q
GV
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
S
D
-
K
---
Q
I
Q
-
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
-------------
N
---------------------------------
G
A
S
R
A
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
D
L
L
-------
41
PsiBlast_CBE
86.20
31%
-96
- C2 -
1SZE
2
CYB2_YEAST
B:
[122-478]
---
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
G
E
K
D
V
A
R
G
C
G
Q
GV
T
K
V
P
Q
M
I
S
T
A
A
S
C
S
P
E
E
I
I
E
A
A
P
S
D
-
K
---
Q
I
Q
-
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
----------------------------------------------------
A
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
D
L
L
-------
59
PsiBlast_CBE
86.12
31%
-89
- C2 -
2ZFA
2
?
A:
[19-360]
---
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
K
E
A
G
T
A
R
A
V
S
E
--
F
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
---
S
E
G
L
N
G
---
G
P
R
-
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
----------------------------
F
G
M
P
I
V
Q
R
Y
----
L
R
G
T
A
E
--------
Y
G
A
S
K
Q
K
I
S
P
R
----
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
------------
57
PsiBlast_CBE
85.42
31%
-94
- C2 -
2NLI
3
?
A:
[13-354]
---
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
K
E
A
G
T
A
R
A
V
S
E
--
F
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
---
S
E
G
L
N
G
---
G
P
R
-
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
---
N
R
D
--------
Y
P
--------------------
F
G
M
P
I
V
Q
R
Y
----
L
R
G
T
A
E
G
M
------
Y
G
A
S
K
Q
K
I
S
P
R
----
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
------------
58
PsiBlast_CBE
83.45
31%
-97
- C2 -
2ZFA
2
?
B:
[19-360]
---
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
K
E
A
G
T
A
R
A
V
S
E
--
F
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
---
S
E
G
L
N
G
---
G
P
R
-
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
----------------------------------------------------------------
A
S
K
Q
K
I
S
P
R
----
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
------------
56
PsiBlast_CBE
83.32
31%
-98
- C2 -
2NLI
3
?
B:
[13-354]
---
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
K
E
A
G
T
A
R
A
V
S
E
--
F
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
---
S
E
G
L
N
G
---
G
P
R
-
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
-------------------------------------------------------------------
S
K
Q
K
I
S
P
R
----
D
I
E
E
I
A
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N
-----
K
R
-----
V
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A
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------------