@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2390: (2016-02-07 )
MENATQPVPLIELRDIRKRYGGNGTPEVEVLKGVSLSIHAGEFVAIVGASGSGKSTLMNILGCLDRPSSGSYHFAGHDVAELDSDEQAWLRREAFGFVFQGYHLIPSASAQENVEMPAIYAGIPASERHTRARALLERLGLAERTANRPHQLSGGQQQRVSIARALMNGGHIILADEPTGALDSHSGAEVMALLDELASQGHVVILITHDRDVAARAKRIIEVRDGEIVSDSANDERPAHPSAGVERHLQADDLSQRLAEGSSEPSGAWRAELLEAVRAAWRVMWINRFRTALTLLGIIIGVASVVVMLAVGEGSKRQVMAQMGAFGSNIIYLSGYSPNPRAPMGIVSSDDVAAIATLPQVKKVMPVNGGELVVRYGNIDYHAYVGGNNTDFPEILNWPVAEGSYFTERDEDAATTVAVIGYKVRKKLFGSANPIGRYILIENVPFQVIGVLAEKGSSSGDKDADNRIAIPYSAASIRLFGTRNPEYVIIAAADAQRVHQAERAIDQLMLRLHRGQRDYELTNNAAMIQAEAKTQNTLSLMLGSIAAISLLVGGIGVMNIMLMTVRERTREIGIRMATGARQGDILRQFLTEAAMLSVVGGLAGIALALCIGGVLLLGQVAVAFSLSAIVGAFSCALVTGLVFGFMPARKAAQLDPVAALASQ
Atome Classification :
(43 SA)
.........10.--.......20........30.........40........50........60........70........80.-...--------....--90........100.......110..-..--------...120--.---.......130.......140..-...-.-.150.......160.......170.......180.......190.......-200..-......210....-.-.-..220.-......230...---.---...240.......250.......260--------........270..-.....280.......290.......300.---......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MENATQP
V
P
L
I
E
--
L
R
D
I
R
K
R
YGGNGTP
E
V
E
V
-
L
K
G
V
S
L
S
I
HA
G
E
F
V
A
I
V
GASGS
G
K
S
T
L
M
N
I
L
G
CLDRPSSG
S
Y
H
FAGH
D
V
A
EL-DS
D
--------
E
Q
A
W
--
L
R
R
E
A
F
G
F
V
F
QGYHLIPSASAQENV-EM--------
P
A
I
YA---G---IPA
S
E
R
H
T
R
A
R
A
L
L
E
RLG
L
A
E
R-TAN-R-PHQLSGG
Q
Q
Q
R
V
S
I
A
R
A
L
MNG
G
H
I
I
L
ADEPTGALDSHSG
A
E
V
M
A
L
L
D
E
L
A
S-Q-G
H
V
-
V
I
L
I
THD
R
-
D
V
A
A
-
R
-
A
-
K
R
I
I
E
V-RDG
E
I
VSDSAND---E---RPAHP
S
A
G
V
E
R
HL
Q
A
D
D
L
S
Q
R
L
AEG---------SSEPSG
A
W
R
A
E
L
L
-
E
A
V
R
A
A
W
R
V
M
W
I
N
R
F
R
T
A
L
T
L
L
G
I
I
I
G
V
A
---
S
V
V
V
M
LAVGEG
S
K
R
Q
V
M
A
Q
MGAFGS
N
I
I
Y
LSGYSPNPRAPMGIVSSD
D
V
A
A
I
A
T
L
P
Q
V
K
KVMPVNG
G
E
L
V
V
R
YGN
I
D
Y
H
A
Y
VGGNNT
D
F
P
E
ILNWPVAEGSYFTERDEDAA
T
T
V
A
V
I
G
Y
K
V
R
K
K
LFGSANP
I
G
R
Y
I
L
IENV
P
F
Q
V
I
G
V
L
A
EKGSSSGDKDADN
R
I
A
I
P
YS
A
A
S
I
R
L
F
GTRNP
E
Y
V
I
I
AAA
D
A
Q
R
V
H
Q
A
E
R
A
I
D
Q
L
M
L
R
L
HRGQRDYELTNN
A
A
M
I
Q
A
EAKT
Q
N
T
L
S
L
M
L
G
S
I
A
A
I
S
L
L
V
G
G
I
G
V
M
N
I
M
L
M
T
V
R
E
R
T
R
EI
G
I
R
MATGAR
Q
G
D
I
L
R
Q
F
L
T
E
A
A
M
L
S
V
V
G
G
L
A
G
I
A
L
A
L
C
I
G
G
V
L
L
L
G
Q
V
A
V
A
F
S
L
S
A
I
V
G
A
F
S
C
A
L
V
T
G
L
V
F
G
FMPARKAAQLD
P
V
A
A
LASQ
21
PsiBlast_CBE
86.91
48%
-101
- C3 -
1L2T
4
Y796_METJA
B:
[1-223]
---------
M
I
K
--
L
K
N
V
T
K
T
Y
K
M
-
G
E
E
I
I
Y
A
-
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
-
D
D
D
--------
E
L
T
K
--
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
--------
P
L
I
F
K
YRG
A
---
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
-
F
A
N
H
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
D
G
K
T
-
V
V
V
V
T
H
D
I
-
N
V
A
R
-
F
-
G
-
E
R
I
I
Y
L
-
K
D
G
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.91
47%
-102
- C3 -
3TIF
7
Y796_METJA
A:
[1-223]
---------
M
V
K
--
L
K
N
V
T
K
T
Y
K
M
-
G
E
E
I
I
Y
A
-
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
-
D
D
D
--------
E
L
T
K
--
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
--------
P
L
I
F
K
YR
G
A
---
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
-
F
A
N
H
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
D
G
K
T
-
V
V
V
V
T
H
D
I
-
N
V
A
R
-
F
-
G
-
E
R
I
I
Y
L
-
K
D
G
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.90
48%
-95
- C3 -
1F3O
2
Y796_METJA
A:
[2-223]
----------
I
K
--
L
K
N
V
T
K
T
Y
K
M
-
G
E
E
I
I
Y
A
-
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
-
D
D
D
--------
E
L
T
K
--
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
--------
P
L
I
F
K
YRG
A
---
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
-
F
A
N
H
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
D
G
K
T
-
V
V
V
V
T
H
D
I
-
N
V
A
R
-
F
-
G
-
E
R
I
I
Y
L
-
K
D
G
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.86
48%
-101
- C3 -
1L2T
4
Y796_METJA
A:
[1-223]
---------
M
I
K
--
L
K
N
V
T
K
T
Y
K
M
-
G
E
E
I
I
Y
A
-
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
-
D
D
D
--------
E
L
T
K
--
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
--------
P
L
I
F
K
YR
G
A
---
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
-
F
A
N
H
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
D
G
K
T
-
V
V
V
V
T
H
D
I
-
N
V
A
R
-
F
-
G
-
E
R
I
I
Y
L
-
K
D
G
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.80
47%
-105
- C3 -
3TIF
7
Y796_METJA
B:
[1-223]
---------
M
V
K
--
L
K
N
V
T
K
T
Y
K
M
-
G
E
E
I
I
Y
A
-
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
-
D
D
D
--------
E
L
T
K
--
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
--------
P
L
I
F
K
YRG
A
---
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
-
F
A
N
H
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
D
G
K
T
-
V
V
V
V
T
H
D
I
-
N
V
A
R
-
F
-
G
-
E
R
I
I
Y
L
-
K
D
G
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
83.44
46%
-93
- C3 -
3TIF
7
Y796_METJA
A:
[1-230]
---------
M
V
K
--
L
K
N
V
T
K
T
Y
K
M
G
E
-
E
I
I
Y
A
-
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
-
D
D
D
--------
E
L
T
K
--
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
--------
P
L
I
F
K
---
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
-
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
-
G
K
T
-
V
V
V
V
T
H
D
I
-
N
V
A
R
-
F
-
G
-
E
R
I
I
Y
L
-
K
D
G
E
V
E
R
E
E
K
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Fugue
81.50
28%
-92
- C3 -
3TUZ
3
METN_ECOLI
H:
[23-362]
--------
H
M
I
K
--
L
S
N
I
T
K
V
F
H
Q
-
G
T
R
T
I
Q
A
-
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
-
S
E
S
--------
E
L
T
K
--
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
--------
P
L
E
L
D
---
N
---
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
-
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
-
I
L
L
I
T
H
E
M
-
D
V
V
K
-
R
I
C
-
D
C
V
A
V
I
-
S
N
G
E
L
I
E
Q
D
T
V
S
---
E
---
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
YQERLQAEP
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
GGV
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
80.22
43%
-92
- C3 -
2PCJ
-
LOLD_AQUAE
A:
[2-223]
-------
A
E
I
L
R
--
A
E
N
I
K
K
V
I
R
G
-----
Y
E
I
-
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
-
N
E
K
--------
E
L
S
L
--
L
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
-
I
V
--------
P
M
L
K
M
---
G
---
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
K
-
L
S
R
-
K
-
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
-
G
-
G
T
S
-
I
V
M
V
T
H
E
R
-
E
L
A
E
-
L
-
T
-
H
R
T
L
E
M
-
K
D
G
K
V
V
G
E
I
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.32
45%
-88
- C3 -
2PCJ
-
LOLD_AQUAE
A:
[18-220]
------------------------------
E
I
-
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
-
N
E
K
--------
E
L
S
L
--
L
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
-
I
V
--------
P
M
L
K
M
---
G
---
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
K
-
L
S
R
-
K
-
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
-
G
-
G
T
S
-
I
V
M
V
T
H
E
R
-
E
L
A
E
-
L
-
T
-
H
R
T
L
E
M
-
K
D
G
K
V
V
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.91
34%
-84
- C3 -
3TUZ
1
METN_ECOLI
C:
[24-257]
---------
M
I
K
--
L
S
N
I
T
K
V
F
H
-
Q
G
T
R
T
I
Q
A
-
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
-
S
E
S
--------
E
L
T
K
--
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
--------
P
L
E
L
D
---
N
---
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
-
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
-
I
L
L
I
T
H
E
M
-
D
V
V
K
-
R
-
I
-
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
---
E
---
V
F
S
H
P
K
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.70
34%
-82
- C3 -
3TUI
1
METN_ECOLI
C:
[24-257]
---------
M
I
K
--
L
S
N
I
T
K
V
F
H
-
Q
G
T
R
T
I
Q
A
-
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
-
S
E
S
--------
E
L
T
K
--
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
--------
P
L
E
L
D
---
N
---
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
-
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
-
I
L
L
I
T
H
E
M
-
D
V
V
K
-
R
-
I
-
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
---
E
---
V
F
S
H
P
K
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.74
45%
-90
- C3 -
2PCL
12
LOLD_AQUAE
A:
[18-220]
------------------------------
E
I
-
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
-
N
E
K
--------
E
L
S
L
--
L
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
-
I
V
--------
P
M
L
K
M
---
G
---
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
K
-
L
S
R
-
K
-
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
-
G
-
G
T
S
-
I
V
M
V
T
H
E
R
-
E
L
A
E
-
L
-
T
-
H
R
T
L
E
M
-
K
D
G
K
V
V
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.27
35%
-90
- C3 -
4YMV
1
?
J:
[1-222]
---------
M
I
F
--
V
N
D
V
Y
K
N
F
G
S
-----
L
E
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
---
N
G
K
--------
V
N
I
N
--
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A-------
P
V
K
V
K
---
K
---
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
-
K
D
Q
-
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
---
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
73.13
33%
-85
- C3 -
3TUI
1
METN_ECOLI
C:
[23-254]
--------
H
M
I
K
--
L
S
N
I
T
K
V
F
H
Q
G
T
-
R
T
I
Q
A
-
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
-
S
E
S
--------
E
L
T
K
---
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
--------
P
L
E
L
D
---
N
---
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
-
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
-
G
L
T
-
I
L
L
I
T
H
E
M
-
D
V
V
K
R
I
-
C
-
D
C
V
A
V
I
-
S
N
G
E
L
I
E
Q
D
T
V
S
---
E
---
V
F
S
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
72.39
35%
-93
- C3 -
4YMV
1
?
A:
[1-222]
---------
M
I
F
--
V
N
D
V
Y
K
N
F
G
S
-----
L
E
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
---
N
G
K
--------
V
N
I
N
--
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A-------
P
V
K
V
K
---
K
---
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
-
K
D
Q
-
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
---
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
72.28
35%
-74
- C3 -
2IT1
-
?
A:
[4-231]
----------
I
K
--
L
E
N
I
V
K
K
F
G
-
N
F
T
----
A
-
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
T
E
L
-
P
P
K
--------
D
R
N
--------
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
-
A
F
--------
P
L
E
L
R
---
K
---
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
-
L
N
R
-
Y
-
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
-
E
L
G
I
T
-
T
V
Y
V
T
H
D
Q
A
E
A
L
A
-
M
-
A
-
D
R
I
A
V
I
-
R
E
G
E
I
L
Q
V
G
T
P
D
---
E
V
Y
Y
K
P
K
Y
K
F
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
72.20
36%
-85
- C3 -
4U00
3
?
A:
[3-230]
--------
P
I
I
R
--
I
R
N
L
H
K
W
F
G
P
-----
L
H
V
-
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
-----
K
D
--------
D
R
A
L
R
E
I
R
R
E
V
-
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
-
T
L
A
-------
P
M
R
V
R
---
R
---
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
-
A
R
K
-
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
-
G
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
V
A
-
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
---
E
---
I
F
T
R
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
71.56
36%
-84
- C3 -
4U02
1
?
A:
[3-230]
--------
P
I
I
R
--
I
R
N
L
H
K
W
F
G
P
-----
L
H
V
-
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
-----
K
D
--------
D
R
A
L
R
E
I
R
R
E
V
-
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
-
T
L
A-------
P
M
R
V
R
---
R
---
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
-
A
R
K
-
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
-
G
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
V
A
-
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
---
E
---
I
F
T
R
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
71.08
35%
-78
- C3 -
2IT1
1
?
B:
[4-231]
----------
I
K
--
L
E
N
I
V
K
K
F
G
-
N
F
T
----
A
-
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
T
E
L
-
P
P
K
--------
D
R
N
--------
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
-
A
F
--------
P
L
E
L
R
---
K
---
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
-
L
N
R
-
Y
-
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
-
E
L
G
I
T
-
T
V
Y
V
T
H
D
Q
A
E
A
L
A
-
M
-
A
-
D
R
I
A
V
I
-
R
E
G
E
I
L
Q
V
G
T
P
D
---
E
V
Y
Y
K
P
K
Y
K
F
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
70.96
35%
-92
- C3 -
4YMW
-
?
J:
[1-222]
---------
M
I
F
--
V
N
D
V
Y
K
N
F
G
S
-----
L
E
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
---
N
G
K
--------
V
N
I
N
--
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A-------
P
V
K
V
K
---
K
---
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
-
K
D
Q
-
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
---
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
70.90
33%
-90
- C3 -
2OLK
1
?
D:
[24-252]
---------
M
I
D
--
V
H
Q
L
K
K
S
F
G
S
-----
L
E
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
--------
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A-------
P
M
K
V
R
---
K
---
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
-
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
DLF
D
---
R
P
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.88
35%
-91
- C3 -
4YMU
2
?
J:
[1-222]
---------
M
I
F
--
V
N
D
V
Y
K
N
F
G
S
-----
L
E
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
---
N
G
K
--------
V
N
I
N
--
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A-------
P
V
K
V
K
---
K
---
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
-
K
D
Q
-
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
---
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
70.81
33%
-96
- C3 -
3C4J
4
?
B:
[24-252]
---------
M
I
D
--
V
H
Q
L
K
K
S
F
G
S
-----
L
E
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
--------
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A-------
P
M
K
V
R
---
K
---
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
-
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
DLF
D
---
R
P
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
70.64
35%
-93
- C3 -
4YMU
2
?
A:
[1-222]
---------
M
I
F
--
V
N
D
V
Y
K
N
F
G
S
-----
L
E
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
---
N
G
K
--------
V
N
I
N
--
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A-------
P
V
K
V
K
---
K
---
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
-
K
D
Q
-
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
---
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
70.10
36%
-79
- C3 -
1B0U
4
HISP_SALTY
A:
[11-246]
----------------
D
L
H
K
R
Y
G
G
H
-----
E
V
-
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
K
D
GQLKVAD
K
N
Q
L
R
--
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
--------
P
I
Q
V
L
---
G
---
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
-
A
Q
G
-
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
-
G
K
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
H
V
S
-
S
H
V
I
F
L
-
H
Q
G
K
I
E
E
E
G
D
P
E
---
Q
---
V
F
G
N
P
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
70.05
33%
-95
- C3 -
2OLJ
4
?
A:
[24-252]
---------
M
I
D
--
V
H
Q
L
K
K
S
F
G
S
-----
L
E
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
--------
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A-------
P
M
K
V
R
---
K
---
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
-
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
---
R
P
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
69.89
33%
-91
- C3 -
2Q0H
4
?
B:
[24-252]
---------
M
I
D
--
V
H
Q
L
K
K
S
F
G
S
-----
L
E
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
--------
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A-------
P
M
K
V
R
---
K
---
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
-
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
---
R
P
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
69.53
33%
-92
- C3 -
2OLK
2
?
B:
[24-252]
---------
M
I
D
--
V
H
Q
L
K
K
S
F
G
S
-----
L
E
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
--------
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A-------
P
M
K
V
R
---
K
---
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
-
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
DLF
D
---
R
P
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
69.18
33%
-88
- C3 -
2OLK
1
?
C:
[24-252]
---------
M
I
D
--
V
H
Q
L
K
K
S
F
G
S
-----
L
E
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
--------
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A-------
P
M
K
V
R
---
K
---
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
-
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
DLF
D
---
R
P
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.18
33%
-89
- C3 -
2OLK
1
?
A:
[24-252]
---------
M
I
D
--
V
H
Q
L
K
K
S
F
G
S
-----
L
E
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
--------
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A-------
P
M
K
V
R
---
K
---
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
-
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
---
R
P
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
68.63
33%
-88
- C3 -
2Q0H
4
?
A:
[24-252]
---------
M
I
D
--
V
H
Q
L
K
K
S
F
G
S
-----
L
E
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
--------
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
-------
P
M
K
V
R
---
K
---
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
-
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
---
R
P
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
68.15
33%
-89
- C3 -
3C41
3
?
K:
[3-231]
---------
M
I
D
--
V
H
Q
L
K
K
S
F
G
S
-----
L
E
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
--------
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A-------
P
M
K
V
R
---
K
---
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
-
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
DLF
D
---
R
P
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
67.88
33%
-84
- C3 -
2OLJ
3
?
B:
[24-252]
---------
M
I
D
--
V
H
Q
L
K
K
S
F
G
S
-----
L
E
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
--------
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A-------
P
M
K
V
R
---
K
---
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
-
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
DLF
D
---
R
P
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
67.75
33%
-87
- C3 -
3C4J
3
?
A:
[24-252]
---------
M
I
D
--
V
H
Q
L
K
K
S
F
G
S
-----
L
E
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
--------
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
-------
P
M
K
V
R
---
K
---
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
-
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
---
R
P
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
67.56
33%
-85
- C3 -
3C41
3
?
J:
[3-231]
---------
M
I
D
--
V
H
Q
L
K
K
S
F
G
S
-----
L
E
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
--------
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A-------
P
M
K
V
R
---
K
---
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
-
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
-
M
V
V
V
T
H
E
M
-
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
DLF
D
---
R
P
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
66.59
35%
-69
- C3 -
2FF7
1
A:
[8-236]
----------
I
T
--
F
R
N
I
R
F
R
Y
----
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
-
D
P
N
-----------
W
--
L
R
R
Q
V
-
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
-
S
L
ANPGMS
V
E
K
V
I
Y
A
---
A
---
K
L
A
G
A
-
H
D
F
I
S
E
L
R
E
--
G
Y
N
T
I
-
V
G
E
-
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
-
G
R
T
-
V
I
I
I
A
H
R
L
-
S
T
V
K
-
N
-
A
-
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
---
E
---
L
L
S
E
P
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
65.31
35%
-71
- C3 -
2PMK
1
A:
[4-232]
----------
I
T
--
F
R
N
I
R
F
R
Y
----
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
-
D
P
N
-----------
W
--
L
R
R
Q
V
-
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
-
S
L
ANPGMS
V
E
K
V
I
Y
A
---
A
---
K
L
A
G
A
-
H
D
F
I
S
E
L
R
E
--
G
Y
N
T
I
-
V
G
E
-
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
-
G
R
T
-
V
I
I
I
A
H
R
L
-
S
T
V
K
-
N
-
A
-
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
---
E
---
L
L
S
E
P
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
65.14
34%
-72
- C3 -
2FGK
2
HLYBP_ECOLX
A:
[8-236]
----------
I
T
--
F
R
N
I
R
F
R
Y
----
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
-
D
P
N
-----------
W
--
L
R
R
Q
V
-
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
-
S
L
ANPGMS
V
E
K
V
I
Y
A
---
A
---
K
L
A
G
A
-
H
D
F
I
S
E
L
R
E
--
G
Y
N
T
I
-
V
G
E
-
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
-
G
R
T
-
V
I
I
I
A
H
R
L
-
S
T
V
K
-
N
-
A
-
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
---
E
---
L
L
S
E
P
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
65.08
34%
-67
- C3 -
2FFB
1
A:
[8-236]
----------
I
T
--
F
R
N
I
R
F
R
Y
----
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
-
D
P
N
-----------
W
--
L
R
R
Q
V
-
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
-
S
L
ANPGMS
V
E
K
V
I
Y
A
---
A
---
K
L
A
G
A
-
H
D
F
I
S
E
L
R
E
--
G
Y
N
T
I
-
V
G
E
-
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
-
G
R
T
-
V
I
I
I
A
H
R
L
-
S
T
V
K
-
N
-
A
-
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
---
E
---
L
L
S
E
P
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
63.87
34%
-69
- C3 -
2FGK
2
D:
[8-236]
----------
I
T
--
F
R
N
I
R
F
R
Y
----
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
-
D
P
N
-----------
W
--
L
R
R
Q
V
-
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
-
S
L
ANPGMSVE
K
V
I
Y
A
---
A
---
K
L
A
G
A
-
H
D
F
I
S
E
L
R
E
--
G
Y
N
T
I
-
V
G
E
-
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
-
G
R
T
-
V
I
I
I
A
H
R
L
-
S
T
V
K
-
N
-
A
-
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
---
E
---
L
L
S
E
P
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
63.80
34%
-68
- C3 -
2FGK
2
HLYBP_ECOLX
B:
[8-236]
----------
I
T
--
F
R
N
I
R
F
R
Y
----
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
-
D
P
N
-----------
W
--
L
R
R
Q
V
-
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
-
S
L
ANPGMSVE
K
V
I
Y
A
---
A
---
K
L
A
G
A
-
H
D
F
I
S
E
L
R
E
--
G
Y
N
T
I
-
V
G
E
-
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
-
G
R
T
-
V
I
I
I
A
H
R
L
-
S
T
V
K
-
N
-
A
-
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
---
E
---
L
L
S
E
P
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
63.27
34%
-71
- C3 -
2FGK
2
HLYBP_ECOLX
C:
[8-236]
----------
I
T
--
F
R
N
I
R
F
R
Y
----
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
-
D
P
N
-----------
W
--
L
R
R
Q
V
-
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
-
S
L
ANPGMSVE
K
V
I
Y
A
---
A
---
K
L
A
G
A
-
H
D
F
I
S
E
L
R
E
--
G
Y
N
T
I
-
V
G
E
-
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
-
G
R
T
-
V
I
I
I
A
H
R
L
-
S
T
V
K
-
N
-
A
-
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
---
E
---
L
L
S
E
P
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
58.76
31%
-82
- C3 -
1VCI
1
?
A:
[7-209]
------
V
I
K
M
V
E
V
K
L
E
N
L
T
K
R
F
G
-
N
F
T
----
A
-
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
T
Y
L
-
P
P
K
--------
D
R
N
--------
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
-
A
F
--------
P
L
--
K
---
K
---
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
-
L
N
R
-
Y
-
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
-
K
-
L
K
V
T
T
I
Y
V
T
H
D
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------