@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2641: (2016-02-09 )
MTLTSIGPANRMARSAETHPLTWRLREDAQPVWLEEYQSKDGYAAARKALTQMAQDDIVQTVKDSGLKGRGGAGFPTGVKWGLMPKDESLNIRYLLCNADEMEPNTWKDRMLMEQLPHLLVEGMLISARALKAYRGYIFLRGEYVDAARNLNRAIDEAKAAGLLGKNILGSGFDFELFVHTGAGRYICGEETALINSLEGRRANPRSKPPFPAAVGVWGKPTCVNNVETLCNVPAIVGNGVDWYKTLARPGSEDMGTKLMGFSGKVKNPGLWELPFGVSARELFEDYAGGMRDGFQLKAWQPGGAGTGFLLPEHLDAQMFAGGIAKVGTRMGTGLAMAVDDSINMVSLLRNMEEFFARESCGWCTPCRDGLPWSVKLLRALERGEGQPGDLETLEQLVNFLGPGKTFCAHAPGAVEPLGSALKYFRAEFEAGISRQPSAAPRPATVGA
Atome Classification :
(20 SA)
-----------.........10........20........30---......---..40........50---.........60........70........80........90........100...-----....110.....---..120.......130.......140.......150.......160.......170.......180--.......190.......200.......210.......220.......230..----.....240.......250.......260......---.270....-...280.......290.......300.......310.--.-.......320.-......330-.......340.......350......--.360---------------.......370-.....------------.----------.---380....------.--..---390--..---.---.-.....400.......410.......420....--...430....--...440......----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MTLTSIG
P
A
N
R
MARSAETH
P
L
T
W
R
LREDAQ
P
---
V
W
L
E
E
Y---QSKD
G
Y
A
A
A
R
K
A
L
----
T
Q
M
A
Q
D
D
I
V
Q
T
V
K
DSGLKGRGGAGFPTGVKWGLMPKDESL
N
I
R
Y
L
L
CNADEMEPN-----
T
W
K
D
R
M
L
M
E
Q
L
P
---
H
L
L
V
E
G
M
L
I
S
A
R
A
L
K
A
YR
G
Y
I
F
L
RGE
Y
V
D
A
A
R
N
L
N
R
A
I
D
E
A
K
A
A
GLLG
K
N
ILGSGF
D
F
E
L
F
V
HTG--AGRYICGE
E
T
A
L
I
N
SLEGRRANPRSKPPFPAAVGVWGKPTCVN
N
V
E
T
L
CNV
P
----
A
IVGN
G
V
D
W
Y
K
T
LARPGSEDMGTKLMGFSGKVKN---PGLWELPF-GV
S
A
R
E
L
F
E
D
Y
AGGMRDG
F
Q
L
K
A
WQPGGAGTGFL--
L
--
P
-
E
HL
D
A
Q
M
F
A
G
G
-
I
A
K
V
G
T
RMG-T
G
L
A
M
AVDDS
I
N
M
V
S
L
L
R
N
M
E
E
F
F
A
R--ESCG---------------WCTPCRDGL
P
-
W
S
V
K
L
------------
L
----------
R
---
A
L
E
RGEG------Q--PG---
D
----
L
E
---
T
---
L
-
E
Q
L
V
N
FLGPGK
T
F
CAHAPGA
V
E
P
L
G
S
A
L
K
Y
F
R
--
A
E
F
E
AGISRQ--PSAAPRPATVGA----------------
7
PsiBlast_PDB
99.16
46%
0
- C- -
4HEA
-
1:
[29--3]
-----------------------------------------------
L
D
Y
Y
---
L
R
H
G
G
Y
E
T
A
K
R
V
L
----
K
E
K
T
P
D
E
V
I
E
E
V
K
R
S
G
L
R
G
R
G
G
A
G
F
P
T
G
L
K
W
S
F
M
P
K
D
D
G
K
Q
-
H
Y
L
I
C
N
A
D
E
S
E
P
G
-----
S
F
K
D
R
Y
I
L
E
D
V
P
---
H
L
L
I
E
G
M
I
L
A
G
Y
A
I
R
A
T
V
G
Y
I
Y
V
R
G
E
Y
R
R
A
A
D
R
L
E
Q
A
I
K
E
A
R
A
R
G
Y
L
G
K
N
L
F
G
T
D
F
S
F
D
L
H
V
H
R
G
--
A
G
A
Y
I
C
G
E
E
T
A
L
M
N
S
L
E
G
L
R
A
N
P
R
L
K
P
P
F
P
A
Q
S
G
L
W
G
K
P
T
T
I
N
N
V
E
T
L
A
S
V
V
----
P
I
M
E
R
G
A
D
W
F
A
Q
M
G
T
E
Q
S
K
--
G
M
K
L
Y
Q
I
S
G
P
V
K
R
---
P
G
V
Y
E
L
P
M
-
G
T
T
F
R
E
L
I
Y
E
W
A
G
G
P
L
E
P
I
Q
--
A
I
I
P
G
G
S
S
T
P
P
L
PF
T
--
E
-
E
V
L
D
T
P
M
S
Y
E
H
-
L
Q
A
K
G
S
M
L
G
-
T
G
G
V
I
L
I
P
E
R
V
S
M
V
D
A
M
W
N
L
T
R
F
Y
A
H
--
E
S
C
G
---------------
K
C
T
P
C
R
E
G
V
A
G
F
M
V
N
L
------------
F
----------
A
---
K
I
G
T
G
Q
G
------
E
--
E
K
---
D
----
V
E
---
N
---
L
-
E
A
L
L
P
L
I
-
E
G
R
S
F
C
P
L
A
D
A
A
V
W
P
V
K
G
S
L
R
H
F
K
--
D
Q
Y
L
A
-
L
A
R
E
--
K
R
P
V
P
R
P
S
--------------------
6
PsiBlast_PDB
99.16
46%
0
- C- -
2YBB
-
1:
[29--3]
-----------------------------------------------
L
D
Y
Y
---
L
R
H
G
G
Y
E
T
A
K
R
V
L
----
K
E
K
T
P
D
E
V
I
E
E
V
K
R
S
G
L
R
G
R
G
G
A
G
F
P
T
G
L
K
W
S
F
M
P
K
D
D
G
K
Q
-
H
Y
L
I
C
N
A
D
E
S
E
P
G
-----
S
F
K
D
R
Y
I
L
E
D
V
P
---
H
L
L
I
E
G
M
I
L
A
G
Y
A
I
R
A
T
V
G
Y
I
Y
V
R
G
E
Y
R
R
A
A
D
R
L
E
Q
A
I
K
E
A
R
A
R
G
Y
L
G
K
N
L
F
G
T
D
F
S
F
D
L
H
V
H
R
G
--
A
G
A
Y
I
C
G
E
E
T
A
L
M
N
S
L
E
G
L
R
A
N
P
R
L
K
P
P
F
P
A
Q
S
G
L
W
G
K
P
T
T
I
N
N
V
E
T
L
A
S
V
V
----
P
I
M
E
R
G
A
D
W
F
A
Q
M
G
T
E
Q
S
K
--
G
M
K
L
Y
Q
I
S
G
P
V
K
R
---
P
G
V
Y
E
L
P
M
-
G
T
T
F
R
E
L
I
Y
E
W
A
G
G
P
L
E
P
I
Q
--
A
I
I
P
G
G
S
S
T
P
P
L
PF
T
--
E
-
E
V
L
D
T
P
M
S
Y
E
H
-
L
Q
A
K
G
S
M
L
G
-
T
G
G
V
I
L
I
P
E
R
V
S
M
V
D
A
M
W
N
L
T
R
F
Y
A
H
--
E
S
C
G
---------------
K
C
T
P
C
R
E
G
V
A
G
F
M
V
N
L
------------
F
----------
A
---
K
I
G
T
G
Q
G
------
E
--
E
K
---
D
----
V
E
---
N
---
L
-
E
A
L
L
P
L
I
-
E
G
R
S
F
C
P
L
A
D
A
A
V
W
P
V
K
G
S
L
R
H
F
K
--
D
Q
Y
L
A
-
L
A
R
E
--
K
R
P
V
P
R
P
S
--------------------
5
PsiBlast_PDB
99.16
46%
0
- C- -
3M9S
-
1:
[29--2]
-----------------------------------------------
L
D
Y
Y
---
L
R
H
G
G
Y
E
T
A
K
R
V
L
----
K
E
K
T
P
D
E
V
I
E
E
V
K
R
S
G
L
R
G
R
G
G
A
G
F
P
T
G
L
K
W
S
F
M
P
K
D
D
G
K
Q
-
H
Y
L
I
C
N
A
D
E
S
E
P
G
-----
S
F
K
D
R
Y
I
L
E
D
V
P
---
H
L
L
I
E
G
M
I
L
A
G
Y
A
I
R
A
T
V
G
Y
I
Y
V
R
G
E
Y
R
R
A
A
D
R
L
E
Q
A
I
K
E
A
R
A
R
G
Y
L
G
K
N
L
F
G
T
D
F
S
F
D
L
H
V
H
R
G
--
A
G
A
Y
I
C
G
E
E
T
A
L
M
N
S
L
E
G
L
R
A
N
P
R
L
K
P
P
F
P
A
Q
S
G
L
W
G
K
P
T
T
I
N
N
V
E
T
L
A
S
V
V
----
P
I
M
E
R
G
A
D
W
F
A
Q
M
G
T
E
Q
S
K
--
G
M
K
L
Y
Q
I
S
G
P
V
K
R
---
P
G
V
Y
E
L
P
M
-
G
T
T
F
R
E
L
I
Y
E
W
A
G
G
P
L
E
P
I
Q
--
A
I
I
P
G
G
S
S
T
P
P
L
PF
T
--
E
-
E
V
L
D
T
P
M
S
Y
E
H
-
L
Q
A
K
G
S
M
L
G
-
T
G
G
V
I
L
I
P
E
R
V
S
M
V
D
A
M
W
N
L
T
R
F
Y
A
H
--
E
S
C
G
---------------
K
C
T
P
C
R
E
G
V
A
G
F
M
V
N
L
------------
F
----------
A
---
K
I
G
T
G
Q
G
------
E
--
E
K
---
D
----
V
E
---
N
---
L
-
E
A
L
L
P
L
I
-
E
G
R
S
F
C
P
L
A
D
A
A
V
W
P
V
K
G
S
L
R
H
F
K
--
D
Q
Y
L
A
-
L
A
R
E
--
K
R
P
V
P
R
P
S
--------------------
4
PsiBlast_PDB
99.16
46%
0
- C- -
3IAS
-
1:
[29--2]
-----------------------------------------------
L
D
Y
Y
---
L
R
H
G
G
Y
E
T
A
K
R
V
L
----
K
E
K
T
P
D
E
V
I
E
E
V
K
R
S
G
L
R
G
R
G
G
A
G
F
P
T
G
L
K
W
S
F
M
P
K
D
D
G
K
Q
-
H
Y
L
I
C
N
A
D
E
S
E
P
G
-----
S
F
K
D
R
Y
I
L
E
D
V
P
---
H
L
L
I
E
G
M
I
L
A
G
Y
A
I
R
A
T
V
G
Y
I
Y
V
R
G
E
Y
R
R
A
A
D
R
L
E
Q
A
I
K
E
A
R
A
R
G
Y
L
G
K
N
L
F
G
T
D
F
S
F
D
L
H
V
H
R
G
--
A
G
A
Y
I
C
G
E
E
T
A
L
M
N
S
L
E
G
L
R
A
N
P
R
L
K
P
P
F
P
A
Q
S
G
L
W
G
K
P
T
T
I
N
N
V
E
T
L
A
S
V
V
----
P
I
M
E
R
G
A
D
W
F
A
Q
M
G
T
E
Q
S
K
--
G
M
K
L
Y
Q
I
S
G
P
V
K
R
---
P
G
V
Y
E
L
P
M
-
G
T
T
F
R
E
L
I
Y
E
W
A
G
G
P
L
E
P
I
Q
--
A
I
I
P
G
G
S
S
T
P
P
L
PF
T
--
E
-
E
V
L
D
T
P
M
S
Y
E
H
-
L
Q
A
K
G
S
M
L
G
-
T
G
G
V
I
L
I
P
E
R
V
S
M
V
D
A
M
W
N
L
T
R
F
Y
A
H
--
E
S
C
G
---------------
K
C
T
P
C
R
E
G
V
A
G
F
M
V
N
L
------------
F
----------
A
---
K
I
G
T
G
Q
G
------
E
--
E
K
---
D
----
V
E
---
N
---
L
-
E
A
L
L
P
L
I
-
E
G
R
S
F
C
P
L
A
D
A
A
V
W
P
V
K
G
S
L
R
H
F
K
--
D
Q
Y
L
A
-
L
A
R
E
--
K
R
P
V
P
R
P
S
--------------------
3
PsiBlast_PDB
99.16
46%
0
- C- -
3IAM
-
1:
[29--2]
-----------------------------------------------
L
D
Y
Y
---
L
R
H
G
G
Y
E
T
A
K
R
V
L
----
K
E
K
T
P
D
E
V
I
E
E
V
K
R
S
G
L
R
G
R
G
G
A
G
F
P
T
G
L
K
W
S
F
M
P
K
D
D
G
K
Q
-
H
Y
L
I
C
N
A
D
E
S
E
P
G
-----
S
F
K
D
R
Y
I
L
E
D
V
P
---
H
L
L
I
E
G
M
I
L
A
G
Y
A
I
R
A
T
V
G
Y
I
Y
V
R
G
E
Y
R
R
A
A
D
R
L
E
Q
A
I
K
E
A
R
A
R
G
Y
L
G
K
N
L
F
G
T
D
F
S
F
D
L
H
V
H
R
G
--
A
G
A
Y
I
C
G
E
E
T
A
L
M
N
S
L
E
G
L
R
A
N
P
R
L
K
P
P
F
P
A
Q
S
G
L
W
G
K
P
T
T
I
N
N
V
E
T
L
A
S
V
V
----
P
I
M
E
R
G
A
D
W
F
A
Q
M
G
T
E
Q
S
K
--
G
M
K
L
Y
Q
I
S
G
P
V
K
R
---
P
G
V
Y
E
L
P
M
-
G
T
T
F
R
E
L
I
Y
E
W
A
G
G
P
L
E
P
I
Q
--
A
I
I
P
G
G
S
S
T
P
P
L
PF
T
--
E
-
E
V
L
D
T
P
M
S
Y
E
H
-
L
Q
A
K
G
S
M
L
G
-
T
G
G
V
I
L
I
P
E
R
V
S
M
V
D
A
M
W
N
L
T
R
F
Y
A
H
--
E
S
C
G
---------------
K
C
T
P
C
R
E
G
V
A
G
F
M
V
N
L
------------
F
----------
A
---
K
I
G
T
G
Q
G
------
E
--
E
K
---
D
----
V
E
---
N
---
L
-
E
A
L
L
P
L
I
-
E
G
R
S
F
C
P
L
A
D
A
A
V
W
P
V
K
G
S
L
R
H
F
K
--
D
Q
Y
L
A
-
L
A
R
E
--
K
R
P
V
P
R
P
S
--------------------
2
PsiBlast_PDB
99.16
46%
0
- C- -
3I9V
-
1:
[29--2]
-----------------------------------------------
L
D
Y
Y
---
L
R
H
G
G
Y
E
T
A
K
R
V
L
----
K
E
K
T
P
D
E
V
I
E
E
V
K
R
S
G
L
R
G
R
G
G
A
G
F
P
T
G
L
K
W
S
F
M
P
K
D
D
G
K
Q
-
H
Y
L
I
C
N
A
D
E
S
E
P
G
-----
S
F
K
D
R
Y
I
L
E
D
V
P
---
H
L
L
I
E
G
M
I
L
A
G
Y
A
I
R
A
T
V
G
Y
I
Y
V
R
G
E
Y
R
R
A
A
D
R
L
E
Q
A
I
K
E
A
R
A
R
G
Y
L
G
K
N
L
F
G
T
D
F
S
F
D
L
H
V
H
R
G
--
A
G
A
Y
I
C
G
E
E
T
A
L
M
N
S
L
E
G
L
R
A
N
P
R
L
K
P
P
F
P
A
Q
S
G
L
W
G
K
P
T
T
I
N
N
V
E
T
L
A
S
V
V
----
P
I
M
E
R
G
A
D
W
F
A
Q
M
G
T
E
Q
S
K
--
G
M
K
L
Y
Q
I
S
G
P
V
K
R
---
P
G
V
Y
E
L
P
M
-
G
T
T
F
R
E
L
I
Y
E
W
A
G
G
P
L
E
P
I
Q
--
A
I
I
P
G
G
S
S
T
P
P
L
PF
T
--
E
-
E
V
L
D
T
P
M
S
Y
E
H
-
L
Q
A
K
G
S
M
L
G
-
T
G
G
V
I
L
I
P
E
R
V
S
M
V
D
A
M
W
N
L
T
R
F
Y
A
H
--
E
S
C
G
---------------
K
C
T
P
C
R
E
G
V
A
G
F
M
V
N
L
------------
F
----------
A
---
K
I
G
T
G
Q
G
------
E
--
E
K
---
D
----
V
E
---
N
---
L
-
E
A
L
L
P
L
I
-
E
G
R
S
F
C
P
L
A
D
A
A
V
W
P
V
K
G
S
L
R
H
F
K
--
D
Q
Y
L
A
-
L
A
R
E
--
K
R
P
V
P
R
P
S
--------------------
1
PsiBlast_PDB
99.16
46%
0
- C- -
2FUG
-
NQO15_THET8 (first)
1:
[29-3]
-----------------------------------------------
L
D
Y
Y
---
L
R
H
G
G
Y
E
T
A
K
R
V
L
----
K
E
K
T
P
D
E
V
I
E
E
V
K
R
S
G
L
R
G
R
G
G
A
G
F
P
T
G
L
K
W
S
F
M
P
K
D
D
G
K
Q
-
H
Y
L
I
C
N
A
D
E
S
E
P
G
-----
S
F
K
D
R
Y
I
L
E
D
V
P
---
H
L
L
I
E
G
M
I
L
A
G
Y
A
I
R
A
T
V
G
Y
I
Y
V
R
G
E
Y
R
R
A
A
D
R
L
E
Q
A
I
K
E
A
R
A
R
G
Y
L
G
K
N
L
F
G
T
D
F
S
F
D
L
H
V
H
R
G
--
A
G
A
Y
I
C
G
E
E
T
A
L
M
N
S
L
E
G
L
R
A
N
P
R
L
K
P
P
F
P
A
Q
S
G
L
W
G
K
P
T
T
I
N
N
V
E
T
L
A
S
V
V
----
P
I
M
E
R
G
A
D
W
F
A
Q
M
G
T
E
Q
S
K
--
G
M
K
L
Y
Q
I
S
G
P
V
K
R
---
P
G
V
Y
E
L
P
M
-
G
T
T
F
R
E
L
I
Y
E
W
A
G
G
P
L
E
P
I
Q
--
A
I
I
P
G
G
S
S
T
P
P
L
PF
T
--
E
-
E
V
L
D
T
P
M
S
Y
E
H
-
L
Q
A
K
G
S
M
L
G
-
T
G
G
V
I
L
I
P
E
R
V
S
M
V
D
A
M
W
N
L
T
R
F
Y
A
H
--
E
S
C
G
---------------
K
C
T
P
C
R
E
G
V
A
G
F
M
V
N
L
------------
F
----------
A
---
K
I
G
T
G
Q
G
------
E
--
E
K
---
D
----
V
E
---
N
---
L
-
E
A
L
L
P
L
I
-
E
G
R
S
F
C
P
L
A
D
A
A
V
W
P
V
K
G
S
L
R
H
F
K
--
D
Q
Y
L
A
-
L
A
R
E
--
K
R
P
V
P
R
P
S
--------------------
20
Fugue
97.98
44%
0
- C- -
2FUG
-
?
?:
[7-6]
----------------------
S
G
L
D
P
R
F
E
R
T
L
Y
A
H
V
G
K
E
G
S
---
W
T
L
D
Y
Y
---
L
R
H
G
G
Y
E
T
A
K
R
V
L
----
K
E
K
T
P
D
E
V
I
E
E
V
K
R
S
G
L
R
G
R
G
G
A
G
F
P
T
G
L
K
W
S
F
M
P
K
D
D
G
-
K
Q
H
Y
L
I
C
N
A
D
E
S
E
P
G
-----
S
F
K
D
R
Y
I
L
E
D
V
P
---
H
L
L
I
E
G
M
I
L
A
G
Y
A
I
R
A
T
V
G
Y
I
Y
V
R
G
E
Y
R
R
A
A
D
R
L
E
Q
A
I
K
E
A
R
A
R
G
Y
L
G
K
N
L
F
G
T
D
F
S
F
D
L
H
V
H
R
G
--
A
G
A
Y
I
C
G
E
E
T
A
L
M
N
S
L
E
G
L
R
A
N
P
R
L
K
P
P
F
P
A
Q
S
G
L
W
G
K
P
T
T
I
N
N
V
E
T
L
A
S
V
V
----
P
I
M
E
R
G
A
D
W
F
A
Q
M
G
T
E
Q
S
K
--
G
M
K
L
Y
Q
I
S
G
P
V
K
R
---
P
G
V
Y
E
L
P
M
-
G
T
T
F
R
E
L
I
Y
E
W
A
G
G
P
L
E
--
P
I
Q
A
I
I
P
G
G
S
S
T
P
P
L
--
P
FT
E
-
E
V
L
D
T
P
M
S
Y
E
H
-
L
Q
A
K
G
S
M
L
G
-
T
G
G
V
I
L
I
P
E
R
V
S
M
V
D
A
M
W
N
L
T
R
F
Y
A
H
--
E
S
C
G
---------------
K
C
T
P
C
R
E
G
V
A
G
F
M
V
N
L
------------
F
----------
A
---
K
I
G
T
G
Q
G
------
E
--
E
K
---
D
----
V
E
---
N
---
L
-
E
A
L
L
P
L
I
E
-
G
R
S
F
C
P
L
A
D
A
A
V
W
P
V
K
G
S
L
R
H
F
K
--
D
Q
Y
L
A
L
A
R
E
K
--
R
P
V
P
R
P
S
L
W
R
------------------
19
PsiBlast_CBE
97.78
46%
-85
- C3 -
2FUG
32
NQO1_THET8
J:
[29-435]
-----------------------------------------------
L
D
Y
Y
---
L
R
H
G
G
Y
E
T
A
K
R
V
L
----
K
E
K
T
P
D
E
V
I
E
E
V
K
R
S
G
L
R
G
R
G
G
A
G
F
P
T
G
L
K
W
S
F
M
P
K
D
D
G
K
Q
-
H
Y
L
I
C
N
A
D
E
S
E
P
G
-----
S
F
K
D
R
Y
I
L
E
D
V
P
---
H
L
L
I
E
G
M
I
L
A
G
Y
A
I
R
A
T
V
G
Y
I
Y
V
R
G
E
Y
R
R
A
A
D
R
L
E
Q
A
I
K
E
A
R
A
R
G
Y
L
G
K
N
L
F
G
T
D
F
S
F
D
L
H
V
H
R
G
--
A
G
A
Y
I
C
G
E
E
T
A
L
M
N
S
L
E
G
L
R
A
N
P
R
L
K
P
P
F
P
A
Q
S
G
L
W
G
K
P
T
T
I
N
N
V
E
T
L
A
S
V
V
----
P
I
M
E
R
G
A
D
W
F
A
Q
M
G
T
E
Q
S
K
--
G
M
K
L
Y
Q
I
S
G
P
V
K
R
---
P
G
V
Y
E
L
P
M
-
G
T
T
F
R
E
L
I
Y
E
W
A
G
G
P
L
E
P
I
Q
--
A
I
I
P
G
G
S
S
T
P
P
L
PF
T
--
E
-
E
V
L
D
T
P
M
S
Y
E
H
-
L
Q
A
K
G
S
M
L
G
-
T
G
G
V
I
L
I
P
E
R
V
S
M
V
D
A
M
W
N
L
T
R
F
Y
A
H
--
E
S
C
G
---------------
K
C
T
P
C
R
E
G
V
A
G
F
M
V
N
L
------------
F
----------
A
---
K
I
G
T
G
Q
G
------
E
--
E
K
---
D
----
V
E
---
N
---
L
-
E
A
L
L
P
L
I
-
E
G
R
S
F
C
P
L
A
D
A
A
V
W
P
V
K
G
S
L
R
H
F
K
--
D
Q
Y
L
A
-
L
A
R
E
--
K
R
P
V
P
R
P
S
--------------------
30
HHSearch
97.75
45%
0
- C- -
3I9V
-
1:
[12--3]
---------------------------
R
F
E
R
T
L
Y
A
H
V
G
K
E
G
S
---
W
T
L
D
Y
Y
---
L
R
H
G
G
Y
E
T
A
K
R
V
L
----
K
E
K
T
P
D
E
V
I
E
E
V
K
R
S
G
L
R
G
R
G
G
A
G
F
P
T
G
L
K
W
S
F
M
P
K
D
D
-
G
K
Q
H
Y
L
I
C
N
A
D
E
S
E
P
G
-----
S
F
K
D
R
Y
I
L
E
D
V
P
---
H
L
L
I
E
G
M
I
L
A
G
Y
A
I
R
A
T
V
G
Y
I
Y
V
R
G
E
Y
R
R
A
A
D
R
L
E
Q
A
I
K
E
A
R
A
R
G
Y
L
G
K
N
L
F
G
T
D
F
S
F
D
L
H
V
H
R
G
--
A
G
A
Y
I
C
G
E
E
T
A
L
M
N
S
L
E
G
L
R
A
N
P
R
L
K
P
P
F
P
A
Q
S
G
L
W
G
K
P
T
T
I
N
N
V
E
T
L
A
S
V
V
----
P
I
M
E
R
G
A
D
W
F
A
Q
M
G
T
E
--
Q
S
K
G
M
K
L
Y
Q
I
S
G
P
V
K
R
---
P
G
V
Y
E
L
P
M
-
G
T
T
F
R
E
L
I
Y
E
W
A
G
G
P
L
-
E
-
P
I
Q
A
I
I
P
G
G
S
S
T
P
P
L
--
P
FT
E
-
E
V
L
D
T
P
M
S
Y
E
H
-
L
Q
A
K
G
S
M
L
G
-
T
G
G
V
I
L
I
P
E
R
V
S
M
V
D
A
M
W
N
L
T
R
F
Y
A
H
--
E
S
C
G
---------------
K
C
T
P
C
R
E
G
V
A
G
F
M
V
N
L
------------
F
----------
A
---
K
I
G
T
G
Q
G
------
E
--
E
K
---
D
----
V
E
---
N
---
L
-
E
A
L
L
P
L
I
-
E
G
R
S
F
C
P
L
A
D
A
A
V
W
P
V
K
G
S
L
R
H
F
K
--
D
Q
Y
L
A
L
A
R
E
K
--
R
P
V
P
R
P
----------------------
22
Fugue
61.11
21%
-29
- C3 -
4NDN
1
MAT2B_HUMAN
F:
[15-323]
-----------------------------
I
P
N
R
R
V
L
V
T
G
A
T
G
------------------
L
L
G
R
A
V
H
----
K
E
F
Q
Q
N
N
W
----------
H
A
V
G
C
G
F
R
-----
R
A
R
P
K
F
E
Q
V
N
L
L
----------
D
S
-----
N
A
V
H
H
I
I
H
D
F
Q
P
---
H
V
I
V
H
C
A
A
--------------
E
R
R
P
D
V
D
A
A
S
Q
L
N
V
-----
D
A
S
G
N
L
A
K
E
A
A
A
V
G
A
---
F
L
I
Y
I
S
--
S
D
Y
V
F
D
G
T
N
P
P
Y
R
E
E
D
I
P
A
P
L
N
L
Y
G
K
T
K
L
D
G
E
K
A
V
L
E
N
----
N
L
G
A
A
V
L
R
I
P
----
I
L
Y
G
E
----
V
E
K
L
E
E
S
A
V
T
V
M
F
D
K
V
Q
-
F
S
N
K
S
A
N
---
M
D
H
W
Q
Q
R
F
-
P
T
H
----
V
K
D
V
A
T
V
C
R
Q
L
A
E
K
R
M
L
D
P
S
I
K
G
T
F
H
W
--
S
--
G
N
E
Q
M
T
K
Y
E
M
A
C
A
-
I
A
D
A
F
N
L
P
S
-
S
H
L
R
P
I
T
D
S
P
V
L
G
A
Q
R
P
R
N
A
Q
-------------------------------------
L
D
C
S
K
------------
L
----------
E
---
T
L
G
I
G
Q
R
------
T
--
P
--------------------------------------------------
F
R
--
I
G
I
K
E
S
L
W
P
F
--
L
I
D
K
R
W
R
Q
T
V
F
H
----------------
21
Fugue
55.53
22%
-34
- C3 -
4N5H
5
?
X:
[1-315]
----------M
A
D
E
E
A
M
L
A
K
V
Q
A
S
W
A
Q
T
A
A
R
D
K
A
R
Y
A
D
E
R
V
P
EDV
H
W
E
T
E
Y
RYE
Q
S
A
D
P
Q
Q
T
L
N
L
Y
Y
----
P
A
K
R
R
N
A
T
M
P
T
V
I
D
I
----
H
G
G
---------
G
W
F
Y
G
D
R
N
L
N
R
N
Y
C
R
Y
L
A
S
Q
------------------------
G
Y
A
V
M
G
M
-----------
G
Y
R
L
L
P
D
--
V
D
L
R
G
Q
I
Q
D
I
F
A
S
L
R
W
L
S
H
F
G
P
Q
R
---
G
F
D
L
D
H
V
L
L
T
G
DS
A
G
G
H
L
A
S
L
V
A
C
I
Q
Q
S
A
E
L
Q
E
L
F
G
V
S
R
V
N
F
N
F
T
L
V
A
L
V
C
P
--
V
A
E
P
S
K
L
P
E
A
A
----
G
D
M
S
D
M
A
A
F
Y
L
D
K
L
S
G
G
D
Q
A
L
V
D
H
L
-
N
F
S
Q
V
V
K
G
---
L
D
L
--
P
P
F
-
M
L
I
---------
G
G
Q
N
D
S
F
-------------
Y
L
--
Q
--
S
-
Q
A
L
L
K
V
F
D
A
N
H
-
V
-----------------------------------------------------------------
T
-
Y
T
T
K
L
------------
W
----------
P
---
A
S
A
G
P
H
--------------------
L
K
---
H
---
V
-
F
N
V
Q
H
W
---------
E
W
P
E
S
I
E
T
N
L
E
M
L
R
T
F
D
--
A
L
S
K
Q
Q
D
Q
A
E
--
E
N
E
-------------------------
24
Fugue
54.19
16%
13
- C3 -
4ZH0
-
?
A:
[18-518]
Q
D
L
S
D
R
Y
E
S
L
N
N
L
L
N
R
Y
S
T
L
N
T
L
I
K
L
S
A
D
P
S
A
I
N
A
V
R
E
N
L
G
A
---
S
A
K
N
L
I
---
G
D
K
A
N
S
P
A
Y
Q
A
V
L
L
A
I
N
A
A
V
G
F
W
N
V
V
G
Y
V
T
Q
C
G
G
N
A
N
G
Q
K
S
I
S
S
K
T
I
F
N
N
E
P
G
Y
R
S
T
S
I
T
---
C
S
L
N
G
H
S
P
G
YYGPM
S
I
E
N
F
K
K
L
N
E
A
Y
---
Q
I
L
Q
T
A
L
K
R
G
L
P
A
L
K
E
N
N
G
K
V
N
V
T
Y
T
Y
T
C
S
G
D
G
N
N
N
C
S
S
Q
V
T
-----
G
V
N
N
Q
K
D
G
T
K
T
K
I
Q
T
I
D
G
-----------
K
S
V
T
T
T
I
S
S
K
V
V
D
S
R
A
D
-------
G
N
T
T
G
V
S
Y
T
E
I
T
N
K
L
E
G
V
P
DS
A
Q
A
L
L
A
Q
A
S
T
L
I
N
T
I
N
N
A
C
P
Y
F
H
A
P
K
F
S
T
T
T
G
K
I
C
G
A
F
S
E
E
I
S
A
I
Q
K
M
I
T
D
A
Q
E
L
V
N
Q
T
S
V
I
N
E
H
E
Q
T
----
T
P
V
G
N
N
N
G
K
P
--
F
--
N
-
P
F
T
D
A
-
S
F
A
Q
G
M
L
A
N
A
S
A
Q
A
K
M
L
N
L
A
E
Q
V
G
Q
A
I
N
P
E
R
L
S
G
T
F
Q
N
F
V
K
G
FL
A
T
C
N
NPSQGSAPGTVTTQT
F
A
S
G
C
A
Y
V
G
Q
-
T
I
T
N
L
------------
K
----------
N
---
S
I
A
H
F
G
T
------
Q
--
E
Q
---
Q
----
I
Q
---
Q
---
A
-
E
N
I
A
D
T
L
V
N
F
K
S
R
Y
S
E
L
G
N
T
Y
N
S
I
T
T
A
L
S
N
I
P
NA
Q
S
L
Q
N
A
V
S
K
K
N
N
P
Y
S
P
Q
G
I
D
T
N
Y
Y
L
N
Q
N
S
Y
N
Q
I
Q
T
I
N
Q
E
L
25
Fugue
52.49
12%
-49
- C3 -
3RHZ
1
?
A:
[10-339]
---------------------------------------
C
M
R
---
V
Y
I
T
N
I
---
N
G
Q
S
I
Q
S
T
A
Q
L
C
Q
----
N
T
V
T
D
V
A
V
S
L
G
Y
R
E
L
G
I
Y
---------------
C
Y
Q
I
H
T
D
S
E
S
E
L
S
K
R
L
D
G
I
V
A
G
-----
L
R
H
G
D
V
V
I
F
Q
T
P
TWN
T
T
E
F
D
E
K
L
M
N
K
L
K
L
Y
D
I
K
I
V
L
F
I
H
D
--
V
V
P
L
M
F
S
G
N
F
Y
L
M
D
R
T
I
A
Y
Y
N
K
A
-------------------
D
V
V
V
A
P
S
Q
K
M
I
D
K
L
R
D
F
G
M
N
V
S
K
T
V
V
Q
----
G
M
W
D
H
P
T
Q
A
P
M
F
P
A
G
L
K
R
E
----
I
H
F
P
G
N
P
E
R
F
S
F
V
K
E
W
-
K
Y
D
I
P
L
K
V
Y
T
W
Q
N
V
E
L
P
---
Q
N
V
H
K
I
N
Y
--
R
P
D
E
Q
L
L
M
E
M
S
Q
G
---
G
F
G
L
-----------
V
W
--
M
--
D
-
D
K
D
K
E
Y
Q
S
L
Y
C
-
S
Y
K
L
G
S
F
L
A
-
A
G
I
P
V
I
V
Q
E
G
I
A
N
-------
Q
E
L
I
E
N
--
N
G
L
G
---------------
W
I
V
K
------------------------------------------------------------
D
----
V
E
---
E
---
A
-
I
M
K
V
K
N
V
N
---------
E
D
E
Y
I
E
L
V
K
N
V
R
S
F
N
--
P
I
L
R
K
G
F
F
T
R
--
R
L
L
T
E
S
V
F
Q
A
I
C
----------------
31
HHSearch
45.05
16%
-45
- C3 -
2BS2
2
FRDB_WOLSU
B:
[145-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
E
L
--
D
R
C
I
---------------
E
C
G
C
C
I
A
A
C
G
-
T
K
I
M
R
EDFVG
A
A
G
L
N
R
V
V
----------
R
---
F
M
I
D
P
H
D
------
E
--
R
T
D
E
-
D
Y
Y
E
L
I
G
---
D
---
D
-
D
G
V
F
G
C
M
--
T
L
L
A
C
H
D
V
C
P
K
N
L
P
L
Q
S
K
I
A
Y
L
R
--
R
K
M
V
S
-----------------------------------
32
HHSearch
44.30
12%
-34
- C3 -
2WDQ
4
SDHB_ECOLI
B:
[143-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
G
L
--
Y
E
C
I
---------------
L
C
A
C
C
S
T
S
C
P
-
S
F
W
W
N
PDKF--------
I
G
P
A
G
L
L
A
A
Y
-
R
---
F
L
I
D
S
R
D
------
T
E
T
D
S
R
L
D
G
----
L
S
---
D
---
A
-
F
S
V
F
R
C
H
--
S
I
M
N
C
V
S
V
C
P
K
G
L
N
P
T
R
A
I
G
H
I
K
--
S
M
L
L
Q
-----------------------------------
36
HHSearch
44.25
17%
-47
- C3 -
3CF4
6
?
A:
[412-478]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
V
--
A
K
C
A
---------------
D
C
G
A
C
L
L
A
C
P
-
E
E
I
D
I
------------
P
----------
E
---
A
M
G
--
F
A
------
K
--
K
G
---
D
----
F
S
---
Y
---
F
E
E
I
H
D
T
C
I
--
G
C
R
R
C
E
Q
V
C
K
K
E
I
P
I
L
N
V
I
E
K
I
-------------------------------------------
33
HHSearch
42.68
12%
-22
- C3 -
2H88
5
SDHB_CHICK
B:
[152-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
G
L
--
Y
E
C
I
---------------
L
C
A
C
C
S
T
S
C
P
-
S
Y
W
W
N
------------
G
DKYLG
P
A
V
L
M
Q
A
Y
R
W
M
I
D
S
R
D
------
D
Y
T
E
E
---
R
----
L
A
---
Q
L
QD
P
-
F
S
L
Y
R
C
H
--
T
I
M
N
C
T
R
T
C
P
K
G
L
N
P
G
K
A
I
A
E
I
K
--
K
M
M
A
T
Y
K
---------------------------------
34
HHSearch
38.18
11%
15
- C3 -
1KF6
3
FRDB_ECOLI
B:
[142-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
Q
F
--
S
G
C
I
---------------
N
C
G
L
C
Y
A
A
C
P
-
Q
F
G
L
N
------------
P
EFIG
P
A
A
I
--
T
---
L
A
H
R
Y
N
E
DSRDHG
K
--
K
E
---
R
----
M
A
Q
L
N
S
---
Q
-
N
G
V
W
S
C
T
--
F
V
G
Y
C
S
E
V
C
P
K
H
V
D
P
A
A
A
I
Q
Q
G
K
--
V
E
S
S
K
D
----------------------------------
35
HHSearch
36.88
16%
-1
- C3 -
1JB0
114
PSAC_THEEB
C:
[5-65]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
Y
--
D
T
C
I
---------------
G
C
T
Q
C
V
R
A
C
P
-
T
D
V
L
E
------------
M
----------
V
---
P
W
--
D
G
C
------
K
--
A
G
---
Q
----
I
A
---
S
---
S
-
P
R
T
E
D
C
V
--
G
C
K
R
C
E
T
A
C
P
T
D
F
L
S
I
R
------------------------------------------------