@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2795: (2016-02-11 )
MRPEPTNAPAALSRRFSVAPMMDWTDRHCRFFLRQLSRHTLLYTEMVTTGALLHGDRQRFLRYDECEHPLALQLGGSVPAELAACARLAEEAGYDEVNLNVGCPSDRVQHNMIGACLMGHPALVADCVKAMLDAVEIAVTVKHRIGINGRDSYAELCDFVGQVREAGCRSFTVHARIAILEGLSPKENREVPPLRYEVAAQLKKDFPDLEIVLNGGIKTLEACREHLQTFDGVMLGREAYHNPYLLAAVDSQLFGSEAPPLSRSEALLRLRPYIERHQAEGGAMHHVTRHILGLAQGFPGSRRFRQLLSVDVHKAADPLRVFDQALELLAGR
Atome Classification :
(20 SA)
.........10........20...--------...----...30...----.-.-...40....-....50---------------------.--.------------------------..----.-------.-------------------.-------.60--.----..---.....--------.--------70......------------------------..----------------------80........90-...-.....100---------.---------......110.......120.......130...--....140.......--150.......160.......170.......------------------180-------------------.........190.......200.....-..210.......220...--...--.--230.........240........250.......--260..---.....270...---....280.....---..290....---...300......-.310......-.320.......330---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRPEPTNA
P
A
A
L
S
R
RFSVAP-MMD--------
W
T
D
----
R
H
C
R
F
F
L
R
----
Q
-L-SRH
T
L
L
Y
T
E
-MVTTGA---------------------L--L------------------------HG----
D
-------
R
-------------------
Q
-------
R
F
---
L
----
R
Y
---DECEH--------
P
--------
L
A
L
QLGGS------------------------V
P
----------------------
A
E
L
A
A
C
A
R
L
A
E
E-AGY-
D
E
V
N
L
NVG---------C---------P
S
D
R
V
Q
H
N
M
I
G
A
C
LMG
H
P
A
L
V
A
D
C
V
K
A
M
L
D
A
V
--
E
I
A
V
T
V
K
H
R
IGING--
R
D
S
Y
A
E
L
C
D
F
V
G
Q
V
R
EAGC
R
S
F
T
V
H
A
R
I
A
I------------------L---------------------EGLSPKENREVP
P
L
R
Y
E
V
A
A
Q
L
K
K
DFP-
D
L
E
I
V
LNGG
I
K
T
L
E
A
C
R
E
--
H
L
Q
--
T
--
F
--
D
G
V
MLG
R
E
AYH-N
P
Y
L
L
A
AV
D
S
Q
LFGSEAP--PL
S
R
S
---
E
A
L
L
R
L
R
P
Y
I
E
---
R
HQAEGG
A
M
H
H
V
---
T
R
H
I
L
G
L
AQ---GFP
G
S
R
R
F
R
Q
L
L
-
S
V
D
V
HKAA
D
P
-
L
R
V
F
D
Q
A
L
E
L
LAGR---
2
PsiBlast_PDB
98.35
47%
-122
- C3 -
3B0U
3
DUSAL_THET8
X:
[2-312]
-----------
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
T
D
----
R
H
F
R
F
L
V
R
----
Q
-
V
-
S
L
G
V
R
L
Y
T
E
-
M
T
V
D
Q
A
---------------------
V
--
L
------------------------
R
G
----
N
-------
R
-------------------
E
-------
R
L
---
L
----
A
F
---
R
P
E
E
H
--------
P
--------
I
A
L
Q
L
A
G
S
------------------------
D
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
-
F
G
Y
-
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
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I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
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--
K
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T
Y
R
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L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
------------------
L
----------------------
A
L
S
T
K
A
N
R
E
I
P
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P
-
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
--
H
L
K
--
R
--
V
--
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
D
R
R
V
F
G
L
P
R
R
--
P
-
S
R
L
---
E
V
A
R
R
M
R
A
Y
L
E
---
E
E
V
L
K
G
T
P
P
W
A
V
---
L
R
H
M
L
N
L
F
R
---
G
R
P
K
G
R
L
W
R
R
L
L
-
S
-----
E
G
R
S
-
L
Q
A
L
D
R
A
L
R
L
M
------
21
PsiBlast_CBE
98.19
47%
-122
- C3 -
3B0U
2
DUSAL_THET8
Y:
[2-312]
-----------
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
T
D
----
R
H
F
R
F
L
V
R
----
Q
-
V
-
S
L
G
V
R
L
Y
T
E
-
M
T
V
D
Q
A
---------------------
V
--
L
------------------------
R
G
----
N
-------
R
-------------------
E
-------
R
L
---
L
----
A
F
---
R
P
E
E
H
--------
P
--------
I
A
L
Q
L
A
G
S
------------------------
D
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
-
F
G
Y
-
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
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I
L
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A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
------------------
L
----------------------
A
L
S
T
K
A
N
R
E
I
P
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P
-
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
--
H
L
K
--
R
--
V
--
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
D
R
R
V
F
G
L
P
R
R
--
P
-
S
R
L
---
E
V
A
R
R
M
R
A
Y
L
E
---
E
E
V
L
K
G
T
P
P
W
A
V
---
L
R
H
M
L
N
L
F
R
---
G
R
P
K
G
R
L
W
R
R
L
L
-
S
-----
E
G
R
S
-
L
Q
A
L
D
R
A
L
R
L
M
------
3
PsiBlast_PDB
97.56
46%
-117
- C3 -
3B0V
1
DUSAL_THET8
C:
[23-332]
-----------
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
T
D
----
R
H
F
R
F
L
V
R
----
Q
-
V
-
S
L
G
V
R
L
Y
T
E
-
M
T
V
D
Q
A
---------------------
V
--
L
------------------------
R
G
----
N
-------
R
-------------------
E
-------
R
L
---
L
----
A
F
---
R
P
E
E
H
--------
P
--------
I
A
L
Q
L
A
G
S
------------------------
D
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
-
F
G
Y
-
D
E
I
N
L
N
L
G
---------
C
---------
P
S
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K
A
Q
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G
G
Y
G
A
C
L
L
L
D
L
A
R
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R
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L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
------------------
L
----------------------
A
L
S
T
K
A
N
R
E
I
P
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P
-
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
--
H
L
K
--
R
--
V
--
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
D
R
R
V
F
G
L
P
R
R
--
P
-
S
R
L
---
E
V
A
R
R
M
R
A
Y
L
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---
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E
V
L
K
G
T
P
P
W
A
V
---
L
R
H
M
L
N
L
F
R
---
G
R
P
K
G
R
L
W
R
R
L
L
-
S
-----
E
G
R
S
-
L
Q
A
L
D
R
A
L
R
L
-------
50
Fugue
96.61
47%
-125
- C3 -
3B0P
1
DUSAL_THET8
A:
[2-318]
-----------
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
T
D
----
R
H
F
R
F
L
V
R
----
Q
-
V
-
S
L
G
V
R
L
Y
T
E
-
M
T
V
D
Q
A
---------------------
V
--
L
------------------------
R
G
----
N
-------
R
-------------------
E
-------
R
L
---
L
----
A
F
---
R
P
E
E
H
--------
P
--------
I
A
L
Q
L
A
G
S
------------------------
D
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
-
F
G
Y
-
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
--------------------------------------------------
I
P
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P
-
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
--
H
L
K
--
R
--
V
--
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
D
R
R
V
F
G
L
P
R
R
--
P
-
S
R
L
---
E
V
A
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R
M
R
A
Y
L
E
---
E
E
V
L
K
G
T
P
P
W
A
V
---
L
R
H
M
L
N
L
F
R
---
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
-----
R
S
-
L
Q
A
L
D
R
A
L
R
L
M
E
E
E
VGE
22
PsiBlast_CBE
96.35
47%
-127
- C3 -
3B0P
1
DUSAL_THET8
B:
[2-312]
-----------
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
T
D
----
R
H
F
R
F
L
V
R
----
Q
-
V
-
S
L
G
V
R
L
Y
T
E
-
M
T
V
D
Q
A
---------------------
V
--
L
------------------------
R
G
----
N
-------
R
-------------------
E
-------
R
L
---
L
----
A
F
---
R
P
E
E
H
--------
P
--------
I
A
L
Q
L
A
G
S
------------------------
D
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
-
F
G
Y
-
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
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A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
--------------------------------------------------
I
P
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P
-
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
--
H
L
K
--
R
--
V
--
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
D
R
R
V
F
G
L
P
R
R
--
P
-
S
R
L
---
E
V
A
R
R
M
R
A
Y
L
E
---
E
E
V
L
K
G
T
P
P
W
A
V
---
L
R
H
M
L
N
L
F
R
---
G
R
P
K
G
R
L
W
R
R
L
L
-
S
-----
E
G
R
S
-
L
Q
A
L
D
R
A
L
R
L
M
------
1
PsiBlast_PDB
95.61
47%
-128
- C3 -
3B0P
1
DUSAL_THET8
A:
[2-312]
-----------
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
T
D
----
R
H
F
R
F
L
V
R
----
Q
-
V
-
S
L
G
V
R
L
Y
T
E
-
M
T
V
D
Q
A
---------------------
V
--
L
------------------------
R
G
----
N
-------
R
-------------------
E
-------
R
L
---
L
----
A
F
---
R
P
E
E
H
--------
P
--------
I
A
L
Q
L
A
G
S
------------------------
D
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
-
F
G
Y
-
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
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V
K
M
R
L
G
L
E
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
--------------------------------------------------
I
P
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P
-
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
--
H
L
K
--
R
--
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--
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
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E
A
D
R
R
V
F
G
L
P
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R
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P
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S
R
L
---
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V
A
R
R
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A
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L
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---
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L
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T
P
P
W
A
V
---
L
R
H
M
L
N
L
F
R
---
G
R
P
K
G
R
L
W
R
R
L
L
-
S
-----
E
G
R
S
-
L
Q
A
L
D
R
A
L
R
L
M
------
28
HHSearch
90.94
44%
-116
- C3 -
3B0P
1
DUSAL_THET8
A:
[2-318]
-----------
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
T
D
----
R
H
F
R
F
L
V
R
----
Q
-
V
-
S
L
G
V
R
L
Y
T
E
-
M
T
V
D
Q
A
---------------------
V
--
L
------------------------
R
G
----
N
-------
R
-------------------
E
-------
R
L
---
L
----
A
F
---
R
P
E
E
H
--------
P
--------
I
A
L
Q
L
A
G
S
------------------------
D
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
-
F
G
Y
-
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
--------------------------------------------------
I
P
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P
-
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
--
H
L
K
--
R
--
V
--
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
D
R
R
V
F
G
L
P
R
R
P
S
R
L
E
V
A
---
R
R
M
R
A
Y
L
E
E
E
V
---
L
K
---
G
T
P
P
W
A
V
---
L
R
H
M
L
N
L
F
R
---
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
R
S
-
L
Q
A
L
-
D
R
A
L
R
L
M
E
E
E
V
G
E
----
27
HHSearch
73.57
23%
-112
* C3 *
1VHN
4
?
A:
[5-309]
-------------
V
K
V
G
L
A
P
-
M
A
G
--------
Y
T
D
----
S
A
F
R
T
L
A
F
----
E
-
W
-
G
-
A
D
F
A
F
S
E
-
M
V
S
A
K
G
---------------------
F
--
L
------------------------
M
N
----
S
-------
Q
-------------------
K
T
E
-----
E
L
---
L
-----
P
---
Q
P
H
E
R
--------
N
--------
V
A
V
Q
I
F
G
S
------------------------
E
P
----------------------
N
E
L
S
E
A
A
R
I
L
S
E
--
K
Y
-
K
W
I
D
L
N
A
G
---------
C
---------
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
--
S
G
K
F
S
V
K
T
R
L
G
W
E
K
------
N
E
V
E
E
I
Y
R
I
L
V
E
E
G
V
D
E
V
F
I
H
T
R
T
V
V
------------------
Q
-----------------------------
S
F
T
G
R
A
E
W
K
A
L
S
V
L
E
K
----
R
I
P
T
F
V
S
G
D
I
F
T
P
E
D
A
K
R
--
A
L
E
E
S
G
--
C
--
D
G
L
L
V
A
R
G
A
I
G
-
R
P
W
I
F
K
Q
I
K
D
F
L
R
S
G
K
Y
S
--
E
P
S
R
E
E
I
L
R
T
F
E
R
H
L
E
L
L
I
---
K
T
K
G
E
R
K
A
V
V
E
M
---
R
K
F
L
A
G
Y
T
K
---
D
L
K
G
A
R
R
F
R
E
K
V
-
M
K
I
E
E
-
V
Q
I
L
-
K
E
M
F
Y
N
F
I
K
E
V
E
-----
52
Fugue
73.56
26%
-89
- C3 -
4BFA
6
DUSC_ECOLI
A:
[22-338]
-----------
A
S
M
R
V
L
L
A
P
-
M
E
G
--------
V
L
D
----
S
L
V
R
E
L
L
T
----
E
-
V
-
N
D
Y
D
L
C
I
T
E
-
F
V
R
V
V
D
---------------------
Q
--
L
------------------------
L
P
----
V
-------
K
-------------------
V
-------
F
H
---
R
----
I
C
---
P
E
L
Q
N
ASRTPS
G
T
L
--------
V
R
V
Q
L
L
G
Q
------------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
-
L
G
S
-
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
W
D
S
--
G
E
K
K
F
E
I
A
D
A
V
Q
Q
---
A
G
A
T
E
L
V
V
H
G
R
----------------------------------------------
T
K
E
Q
G
Y
R
A
E
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
N
--
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
--
C
M
A
--
I
S
G
C
--
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
S
R
V
V
K
Y
N
-----
E
P
--
R
M
P
W
P
---
E
V
V
A
L
L
Q
K
Y
T
R
---
L
E
K
Q
G
D
T
G
L
Y
H
V
---
A
R
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
-
R
A
I
Q
A
I
D
I
E
K
L
------
51
Fugue
71.17
23%
-95
- C3 -
1VHN
4
?
A:
[5-309]
-------------
V
K
V
G
L
A
P
M
A
-
G
--------
Y
T
D
----
S
A
F
R
T
L
A
F
----
E
-
W
-
G
-
A
D
F
A
F
S
E
M
V
S
A
K
G
F
---------------------
L
---
M
-----------------------
N
S
----
Q
-------
K
-------------------
T
-------
E
E
---
L
----
L
P
---
Q
P
H
E
R
--------
N
--------
V
A
V
Q
I
F
G
S
------------------------
E
P
----------------------
N
E
L
S
E
A
A
R
I
L
S
E
--
K
Y
-
K
W
I
D
L
N
A
G
---------
C
---------
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
--
S
G
K
F
S
V
K
T
R
L
G
W
E
K
--
N
E
----
V
E
E
I
Y
R
I
L
V
E
E
G
V
D
E
V
F
I
H
T
R
-----------------------------------------------
T
V
V
Q
S
F
T
G
R
A
E
W
K
A
L
S
V
L
E
K
R
I
P
----
T
F
V
S
G
D
I
F
T
P
E
D
A
K
R
--
A
L
E
--
E
S
G
C
--
D
G
L
L
V
A
R
G
A
I
G
-
R
P
W
I
F
K
Q
I
K
D
F
L
R
S
G
K
Y
S
--
E
P
S
R
E
---
E
I
L
R
T
F
E
R
H
L
E
---
L
L
I
K
T
K
G
E
R
K
A
V
V
E
M
R
K
F
L
A
G
Y
T
K
---
D
L
K
G
A
R
R
F
R
E
K
V
M
K
I
E
E
V
Q
I
L
K
E
M
F
Y
N
F
I
K
E
V
E
--------
4
PsiBlast_PDB
67.30
25%
-93
- C3 -
4BFA
5
DUSC_ECOLI
A:
[23-295]
------------
S
M
R
V
L
L
A
P
-
M
E
G
--------
V
L
D
----
S
L
V
R
E
L
L
T
----
E
-
V
-
N
D
Y
D
L
C
I
T
E
-
F
V
R
V
V
D
---------------------
Q
--
L
------------------------
L
P
----
V
-------
K
-------------------
V
-------
F
H
---
R
----
I
C
---
P
E
L
Q
N
--------
A
SRTPS
G
T
L
V
R
V
Q
L
L
G
Q
------------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
-
L
G
S
-
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
W
D
S
--
G
E
K
K
F
E
I
A
D
A
V
Q
Q
---
A
G
A
T
E
L
V
V
H
G
R
----------------------------------------------
T
K
E
Q
G
Y
R
A
E
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
--
G
--
C
--
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
-----
S
R
V
V
K
Y
N
E
P
--
R
M
P
W
P
---
E
V
V
A
L
L
Q
K
Y
T
R
---
L
E
K
Q
G
D
T
G
L
Y
H
V
---
A
R
---------------------------------------------------
7
PsiBlast_PDB
67.25
22%
-89
- C3 -
1VHN
4
?
A:
[5-286]
-------------
V
K
V
G
L
A
P
-
M
A
G
--------
Y
T
D
----
S
A
F
R
T
L
A
F
----
E
-
W
-
G
A
D
F
A
F
S
E
M
-
V
S
A
K
G
F
---------------------
L
--
M
------------------------
N
S
----
Q
-------
K
-------------------
T
-------
E
E
---
L
----
L
P
---
Q
P
H
E
R
--------
N
--------
V
A
V
Q
I
F
G
S
------------------------
E
P
----------------------
N
E
L
S
E
A
A
R
I
L
S
E
-
K
-
Y
-
K
W
I
D
L
N
A
G
---------
C
---------
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
--
S
G
K
F
S
V
K
T
R
L
G
W
E
K
--
N
----
E
V
E
E
I
Y
R
I
L
V
E
E
G
V
D
E
V
F
I
H
T
R
T
V
V
------------------
Q
---------------------
S
F
T
G
R
A
E
--------
W
K
A
L
S
V
L
E
K
R
I
P
-
T
F
---
V
S
G
D
I
F
T
P
E
D
A
K
R
--
A
L
E
--
E
--
S
GC
D
G
L
L
V
A
R
G
A
I
G
-
R
P
W
I
F
K
Q
I
K
D
F
L
R
S
G
K
Y
S
--
E
P
S
R
E
---
E
I
L
R
T
F
E
R
H
L
E
L
L
I
K
T
K
G
E
R
K
A
V
V
E
M
---
R
K
F
L
A
G
Y
T
K
---
D
L
K
G
A
R
R
F
R
E
-------------------------------
5
PsiBlast_PDB
66.94
25%
-95
- C3 -
4YCO
1
DUSC_ECOLI
A:
[6-278]
------------
S
M
R
V
L
L
A
P
-
M
E
G
--------
V
L
D
----
S
L
V
R
E
L
L
T
----
E
-
V
-
N
D
Y
D
L
C
I
T
E
-
F
V
R
V
V
D
---------------------
Q
--
L
------------------------
L
P
----
V
-------
K
-------------------
V
-------
F
H
---
R
----
I
C
---
P
E
L
Q
N
--------
A
SRTPS
G
T
L
V
R
V
Q
L
L
G
Q
------------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
-
L
G
S
-
W
G
V
D
L
N
C
G
---------
A
---------
P
S
----
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
W
D
S
--
G
E
K
K
F
E
I
A
D
A
V
Q
Q
---
A
G
A
T
E
L
V
V
H
G
R
----------------------------------------------
T
K
E
Q
G
Y
R
A
E
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
--
G
--
C
--
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
-----
S
R
V
V
K
Y
N
E
P
--
R
M
P
W
P
---
E
V
V
A
L
L
Q
K
Y
T
R
---
L
E
K
Q
G
D
T
G
L
Y
H
V
---
A
R
---------------------------------------------------
6
PsiBlast_PDB
65.57
25%
-93
- C3 -
4YCP
2
DUSC_ECOLI
A:
[7-278]
-------------
M
R
V
L
L
A
P
-
M
E
G
--------
V
L
D
----
S
L
V
R
E
L
L
T
----
E
-
V
-
N
D
Y
D
L
C
I
T
E
-
F
V
R
V
V
D
---------------------
Q
--
L
------------------------
L
P
----
V
-------
K
-------------------
V
-------
F
H
---
R
----
I
C
---
P
E
L
Q
N
--------
A
SRTPS
G
T
L
V
R
V
Q
L
L
G
Q
------------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
-
L
G
S
-
W
G
V
D
L
N
C
G
---------
A
---------
P
-------
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
W
D
S
--
G
E
K
K
F
E
I
A
D
A
V
Q
Q
---
A
G
A
T
E
L
V
V
H
G
R
----------------------------------------------
T
K
E
Q
G
Y
R
A
E
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
--
G
--
C
--
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
-----
S
R
V
V
K
Y
N
E
P
--
R
M
P
W
P
---
E
V
V
A
L
L
Q
K
Y
T
R
---
L
E
K
Q
G
D
T
G
L
Y
H
V
---
A
R
---------------------------------------------------
31
HHSearch
61.48
16%
-86
- C3 -
3KRU
2
?
A:
[6-323]
--
M
P
L
K
I
K
D
I
T
I
K
N
R
I
M
M
S
P
-
M
C
M
--------
Y
S
A
STDG
M
P
N
D
W
H
I
V
H
Y
A
T
R
A
I
-
G
G
V
G
L
I
M
Q
E
-
A
T
A
V
E
S
---------------------
R
--
G
------------------------
R
I
----
T
DHDLGIW
N
-------------------
D
E
Q
V
K
E
L
K
K
I
---
V
D
---
I
C
---
K
A
N
G
A
--------
V
--------
M
G
I
Q
L
A
H
A
GRKCNISYEDVVGPSPIKAGDRYK
L
P
RELS
V
E
E
I
K
S
I
V
----------
K
A
F
G
E
A
A
K
R
A
N
L
-
A
G
Y
-
D
V
V
E
I
H
A
A
HGY
L
I
H
E
F
L
S
---------
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
R
K
N
W
PE
N
K
P
I
F
V
R
V
S
A
D
D
Y
M
EG
G
I
N
I
D
M
M
V
E
Y
I
N
M
I
K
-
D
K
V
D
L
I
D
V
S
S
G
G
L
L
------------------
N
---------------------
V
D
-----
I
N
L
Y
P
G
Y
Q
V
K
Y
A
E
T
I
K
K
R
C
--
N
I
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
--
I
L
S
N
-
E
R-
A
--
D
L
V
A
L
G
R
E
L
L
R
-
N
P
Y
W
V
L
H
T
Y
T
S
---------------------------------------------------------------------------------------------------
32
HHSearch
60.79
21%
-88
- C3 -
3HGJ
2
?
A:
[6-335]
--
T
P
L
E
L
G
G
L
R
L
K
N
R
L
A
M
S
P
-
M
C
Q
YSATLEGE
V
T
D
----
W
H
L
L
H
Y
P
T
----
R
-
A
L
G
G
V
G
L
I
L
V
E
-
A
T
A
V
E
P
---------------------
L
--
G
------------------------
R
I
----
S
PYDLGIW
S
-------------------
E
DH
L
P
G
L
K
E
L
---
A
R
---
R
I
---
R
E
A
G
A
--------
V
--------
P
G
I
Q
L
A
H
A
GRKAGTARPWEGGKPLGWRVVGP-
S
P
IPFDEGYPVPEPLD
E
A
G
M
E
R
I
L
Q
A
F
V
E
G
A
R
R
A
L
R
-
A
G
F
-
Q
V
I
E
L
H
M
A
---------
H
GY
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
V
PR
E
L
P
L
F
V
R
V
S
A
T
D
W
G
EG
G
W
S
L
E
D
T
L
A
F
A
R
R
L
K
E
L
G
V
D
L
L
D
C
S
S
G
G
V
V
------------------
L
---------------------
R
V
----
R
I
P
L
A
P
G
F
Q
V
P
F
A
D
A
V
R
K
R
V
--
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
--
L
L
Q
A
-
G
S-
A
--
D
L
V
L
L
G
R
V
L
L
R
-
D
P
Y
F
P
L
R
A
A
K
A
L
--------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
60.60
26%
-100
- C3 -
4BF9
1
DUSC_ECOLI
A:
[90-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
L
G
Q
------------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
-
L
G
S
-
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
W
D
S
--
G
E
K
K
F
E
I
A
D
A
V
Q
Q
---
A
G
A
T
E
L
V
V
H
G
R
----------------------------------------------
T
K
E
Q
G
Y
R
A
E
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
--
G
--
C
--
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
-----
S
R
V
V
K
Y
N
E
P
--
R
M
P
W
P
---
E
V
V
A
L
L
Q
K
Y
T
R
---
L
E
K
Q
G
D
T
G
L
Y
H
V
---
A
R
---------------------------------------------------
48
HHSearch
58.18
16%
-96
- C3 -
1GTE
2
DPYD_PIG
A:
[534-841]
---
S
V
E
M
A
G
L
K
F
I
N
P
F
G
L
A
S
-
A
A
P
--------
T
T
S
----
S
S
M
I
R
R
A
F
----
E
-
A
-
G
-
W
G
F
A
L
T
K
-
T
F
S
L
D
K
---------------------
D
I
V
T
N
V
S
PR
I
V
R
G
TTSGPMYGPGQS
S
F
L
N
I
ELIS
E
-------
K
T
A
-----------------
A
-------
Y
W
C
Q
S
V
T
E
L
-
K
A
---
D
F
P
D
N
--------
I
--------
V
I
A
S
I
M
C
S
Y-----------------------
N
K
----------------------
N
D
W
M
E
L
S
R
K
A
E
A
-
S
G
A
-
D
A
L
E
L
N
L
S
---------
C
---------
P
H
G
M
G
------
L
A
C
G
Q
D
P
E
L
V
R
N
I
C
R
W
V
R
Q
A
V
--
Q
I
P
F
F
A
K
L
T
P
N
V
T
--------
D
I
V
S
I
A
R
A
A
K
E
G
G
A
D
G
V
T
A
T
N
T
V
S
G
------------------
L
MGLKADGTPWPAVGAGKRT
T
Y
G
G
V
S
---
G
T
A
I
R
P
I
A
L
R
A
V
T
T
I
A
R
A
L
P
-
G
F
P
I
L
A
T
G
G
I
D
S
A
E
S
G
L
Q
--
F
L
H
S
-
G
--
A
--
S
V
L
Q
V
C
S
A
V
Q
N
Q
D
F
T
V
I
Q
D
Y
C
T
G
L
K
-------------------------------------------------------------------------------------------------
44
HHSearch
54.62
16%
-90
- C3 -
1JUB
6
PYRDA_LACLM
A:
[3-288]
---
N
T
T
F
A
N
A
K
F
A
N
P
F
M
N
A
S
-
G
V
H
--------
C
M
T
----
I
E
D
L
E
E
L
K
----
A
-
S
-
Q
-
A
G
A
Y
I
T
K
-
S
S
T
L
E
K
---------------------
R
--
E
------------------------
G
N
PL--
P
-------
R
Y
V
D
L
EL
G
S
I
N
SMGLPNLG
F
D
-------
Y
Y
---
L
D
Y
V
L
K
N
Q
K
E
N
A
Q
E
G
--------
P
--------
I
F
F
S
I
A
G
M
------------------------
S
A
----------------------
A
E
N
I
A
M
L
K
K
I
Q
E
-
S
D
F
S
G
I
T
E
L
N
L
S
---------
C
---------
P
N
V
P
G
-----
E
P
Q
L
A
Y
D
F
E
A
T
E
K
L
L
K
E
V
F
T
F
F
--
T
K
P
L
G
V
K
L
P
P
Y
F
D
L
------
V
H
F
D
I
M
A
E
I
L
N
Q
F
P
L
T
Y
V
N
S
V
N
S
I
G
N
G
L
F
I
DPEAESVVIKPKDG
F
---------------------
G
G
I
G
---
G
A
Y
I
K
P
T
A
L
A
N
V
R
A
F
Y
T
R
L
K
P
E
I
Q
I
I
G
T
G
G
I
E
T
G
Q
D
A
F
E
--
H
L
L
C
-
G
--
A
--
T
M
L
Q
I
G
T
A
L
H
K
E
G
P
A
I
F
D
R
I
I
K
E
---------------------------------------------------------------------------------------------------
49
HHSearch
54.51
18%
-89
- C3 -
1EP3
2
PYRDB_LACLM
A:
[9-287]
----
V
K
L
P
G
L
D
L
K
N
P
I
I
P
A
S
-
G
C
F
--------
G
F
G
----
E
E
Y
A
K
Y
Y
D
----
L
-
N
-
K
-
L
G
S
I
M
V
K
-
A
T
T
L
H
P
RFGNPTPR
V
A
E
T
AS
G
M
L
N
AIG
L
--
Q
------------------------
N
P
----
G
-------
L
-------------------
E
V
I
M
T
---
E
K
---
L
P
W
L
-
N
E
---
N
F
P
E
L
--------
P
--------
I
I
A
N
V
A
G
S
------------------------
E
E
----------------------
A
D
Y
V
A
V
C
A
K
I
G
D
A
A
N
V
-
K
A
I
E
L
N
I
S
---------
C
---------
P
N
V
K
----
H
G
G
Q
A
F
G
T
D
P
E
V
A
A
A
L
V
K
A
C
K
A
V
S
--
K
V
P
L
Y
V
K
L
S
P
N
V
T
--------
D
I
V
P
I
A
K
A
V
E
A
A
G
A
D
G
L
T
M
I
N
T
L
M
G
------------------
V
R
F
D
LKTRQPILANI
T
------
G
G
L
S
---
G
P
A
I
K
P
V
A
L
K
L
I
H
Q
V
A
Q
D
V
--
D
I
P
I
I
G
M
G
G
V
A
N
A
Q
D
V
L
E
--
M
Y
M
A
-
G
--
A
--
S
A
V
A
V
G
T
A
N
F
A
-
D
P
F
V
C
P
K
I
I
D
K
L
--------------------------------------------------------------------------------------------------