@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2831: (2016-02-11 )
MQIRADFDSGNIQVIDASDPRRIRLAIRPDLASQHFQWFHFKVEGMAPATEHCFTLVNAGQSAYSHAWSGYQAVASYDGERWFRVPSQYDADGLHFQLEPEESEVRFAYFEPYSRERHARLVERALGIEGVERLAVGTSVQGRDIELLRVRRHPDSHLKLWVIAQQHPGEHMAEWFMEGLIERLQRPDDTEMQRLLEKADLYLVPNMNPDGAFHGNLRTNAAGQDLNRAWLEPSAERSPEVWFVQQEMKRHGVDLFLDIHGDEEIPHVFAAGCEGNPGYTPRLERLEQRFREELMARGEFQIRHGYPRSAPGQANLALACNFVGQTYDCLAFTIEMPFKDHDDNPEPGTGWSGARSKRLGQDVLSTLAVLVDELR
Atome Classification :
(20 SA)
.........10........20........30........40........50...-.....60........70........80........90........100.......110.......120.....-..-130.......140.......150..----..----...160.......170.......180..----..----.--..190.......200.......210....--------.--------.--------.--------220.......230------------------.-------------------......240.......250-........260..-.-....270...------....280.......290..-....--.300......---------.310--.---.......320.......330.......340.......350........360.......370...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Q
I
R
A
DFDSG
N
I
Q
V
I
DASDP
R
R
I
R
L
A
IRPDLASQ
H
F
Q
W
F
H
F
K
VEGMAP
A
T
E
H
C
F
-
T
L
V
NAG
Q
S
A
Y
S
H
AWS
G
Y
Q
A
V
A
SYDGE
R
W
F
RVPSQYDADG
L
H
F
Q
LEPEES
E
V
R
F
A
Y
FEPYS
R
E
R
H
A
R
L
V
E
R
A
L
G
-
I
E
-
G
V
E
R
L
AVGTSVQGR
D
I
E
L
L
R
V
RRHP----DS----H
L
K
L
W
V
I
AQQHP
G
E
H
M
A
E
W
F
M
E
G
L
I
E
R
L----QR----P--
D
D
T
E
M
Q
R
L
L
E
KA
D
L
Y
L
VPNMNPDG
A
F
HGN--------L--------R--------T--------NAAGQD
L
N
R
A
WLE------------------P-------------------SAERSP
E
V
W
F
V
Q
Q
E
M
K
RH--G
V
D
L
F
L
D
IHGDEE-I-
P
H
V
F
AAGCEG------NPGY
T
P
R
L
E
R
L
E
Q
R
F
R
E
E
L
-
M
ARG--
E
F
Q
I
RHGYPR---------SAP---G---QA
N
L
A
L
A
C
N
FVGQT
Y
D
C
L
A
F
T
I
EMPFKDHDDNPEPGTG-WSG
A
R
S
KRL
G
Q
D
V
L
S
T
L
A
V
L
V
D
ELR
3
PsiBlast_PDB
99.93
100%
-93
- C4 -
4A39
2
?
A:
[14-388]
M
Q
I
R
A
D
F
D
S
G
N
I
Q
V
I
D
A
S
D
P
R
R
I
R
L
A
I
R
P
D
L
A
S
Q
H
F
Q
W
F
H
F
K
V
E
G
M
A
P
A
T
E
H
C
F
-
T
L
V
N
A
G
Q
S
A
Y
S
H
A
W
S
G
Y
Q
A
V
A
S
Y
D
G
E
R
W
F
R
V
P
S
Q
Y
D
A
D
G
L
H
F
Q
L
E
P
E
E
S
E
V
R
F
A
Y
F
E
P
Y
S
R
E
R
H
A
R
L
V
E
R
A
L
G
-
I
E
-
G
V
E
R
L
A
V
G
T
S
V
Q
G
R
D
I
E
L
L
R
V
R
R
H
P
----
D
S
----
H
L
K
L
W
V
I
A
Q
Q
H
P
G
E
H
M
A
E
W
F
M
E
G
L
I
E
R
L
----
Q
R
----
P
--
D
D
T
E
M
Q
R
L
L
E
K
A
D
L
Y
L
V
P
N
M
N
P
D
G
A
F
H
G
N
--------
L
--------
R
--------
T
--------
N
A
A
G
Q
D
L
N
R
A
W
L
E
------------------
P
-------------------
S
A
E
R
S
P
E
V
W
F
V
Q
Q
E
M
K
R
H
--
G
V
D
L
F
L
D
I
H
G
D
E
E
-
I
-
P
H
V
F
A
A
G
C
E
G
------
N
P
G
Y
T
P
R
L
E
R
L
E
Q
R
F
R
E
E
L
-
M
A
R
G
--
E
F
Q
I
R
H
G
Y
P
R
---------
S
A
P
---
G
---
Q
A
N
L
A
L
A
C
N
F
V
G
Q
T
Y
D
C
L
A
F
T
I
E
M
P
F
K
D
H
D
D
N
P
E
P
G
T
G
-
W
S
G
A
R
S
K
R
L
G
Q
D
V
L
S
T
L
A
V
L
V
D
E
L
R
21
PsiBlast_CBE
99.04
100%
-90
- C4 -
4A39
1
?
B:
[14-388]
M
Q
I
R
A
D
F
D
S
G
N
I
Q
V
I
D
A
S
D
P
R
R
I
R
L
A
I
R
P
D
L
A
S
Q
H
F
Q
W
F
H
F
K
V
E
G
M
A
P
A
T
E
H
C
F
-
T
L
V
N
A
G
Q
S
A
Y
S
H
A
W
S
G
Y
Q
A
V
A
S
Y
D
G
E
R
W
F
R
V
P
S
Q
Y
D
A
D
G
L
H
F
Q
L
E
P
E
E
S
E
V
R
F
A
Y
F
E
P
Y
S
R
E
R
H
A
R
L
V
E
R
A
L
G
-
I
E
-
G
V
E
R
L
A
V
G
T
S
V
Q
G
R
D
I
E
L
L
R
V
R
R
H
P
----
D
S
----
H
L
K
L
W
V
I
A
Q
Q
H
P
G
E
H
M
A
E
W
F
M
E
G
L
I
E
R
L
----
Q
R
----
P
--
D
D
T
E
M
Q
R
L
L
E
K
A
D
L
Y
L
V
P
N
M
N
P
D
G
A
F
H
G
N
--------
L
--------
R
--------
T
--------
N
A
A
G
Q
D
L
N
R
A
W
L
E
------------------
P
-------------------
S
A
E
R
S
P
E
V
W
F
V
Q
Q
E
M
K
R
H
--
G
V
D
L
F
L
D
I
H
G
D
E
E
-
I
-
P
H
V
F
A
A
G
C
E
G
------
N
P
G
Y
T
P
R
L
E
R
L
E
Q
R
F
R
E
E
L
-
M
A
R
G
--
E
F
Q
I
R
H
G
Y
P
R
---------
S
A
P
---
G
---
Q
A
N
L
A
L
A
C
N
F
V
G
Q
T
Y
D
C
L
A
F
T
I
E
M
P
F
K
D
H
D
D
N
P
E
P
G
T
G
-
W
S
G
A
R
S
K
R
L
G
Q
D
V
L
S
T
L
A
V
L
V
D
E
L
R
23
PsiBlast_CBE
98.90
100%
-91
- C4 -
4A37
1
?
B:
[14-388]
M
Q
I
R
A
D
F
D
S
G
N
I
Q
V
I
D
A
S
D
P
R
R
I
R
L
A
I
R
P
D
L
A
S
Q
H
F
Q
W
F
H
F
K
V
E
G
M
A
P
A
T
E
H
C
F
-
T
L
V
N
A
G
Q
S
A
Y
S
H
A
W
S
G
Y
Q
A
V
A
S
Y
D
G
E
R
W
F
R
V
P
S
Q
Y
D
A
D
G
L
H
F
Q
L
E
P
E
E
S
E
V
R
F
A
Y
F
E
P
Y
S
R
E
R
H
A
R
L
V
E
R
A
L
G
-
I
E
-
G
V
E
R
L
A
V
G
T
S
V
Q
G
R
D
I
E
L
L
R
V
R
R
H
P
----
D
S
----
H
L
K
L
W
V
I
A
Q
Q
H
P
G
E
H
M
A
E
W
F
M
E
G
L
I
E
R
L
----
Q
R
----
P
--
D
D
T
E
M
Q
R
L
L
E
K
A
D
L
Y
L
V
P
N
M
N
P
D
G
A
F
H
G
N
--------
L
--------
R
--------
T
--------
N
A
A
G
Q
D
L
N
R
A
W
L
E
------------------
P
-------------------
S
A
E
R
S
P
E
V
W
F
V
Q
Q
E
M
K
R
H
--
G
V
D
L
F
L
D
I
H
G
D
E
E
-
I
-
P
H
V
F
A
A
G
C
E
G
------
N
P
G
Y
T
P
R
L
E
R
L
E
Q
R
F
R
E
E
L
-
M
A
R
G
--
E
F
Q
I
R
H
G
Y
P
R
---------
S
A
P
---
G
---
Q
A
N
L
A
L
A
C
N
F
V
G
Q
T
Y
D
C
L
A
F
T
I
E
M
P
F
K
D
H
D
D
N
P
E
P
G
T
G
-
W
S
G
A
R
S
K
R
L
G
Q
D
V
L
S
T
L
A
V
L
V
D
E
L
R
1
PsiBlast_PDB
98.73
100%
-93
- C4 -
4A37
1
?
A:
[14-388]
M
Q
I
R
A
D
F
D
S
G
N
I
Q
V
I
D
A
S
D
P
R
R
I
R
L
A
I
R
P
D
L
A
S
Q
H
F
Q
W
F
H
F
K
V
E
G
M
A
P
A
T
E
H
C
F
-
T
L
V
N
A
G
Q
S
A
Y
S
H
A
W
S
G
Y
Q
A
V
A
S
Y
D
G
E
R
W
F
R
V
P
S
Q
Y
D
A
D
G
L
H
F
Q
L
E
P
E
E
S
E
V
R
F
A
Y
F
E
P
Y
S
R
E
R
H
A
R
L
V
E
R
A
L
G
-
I
E
-
G
V
E
R
L
A
V
G
T
S
V
Q
G
R
D
I
E
L
L
R
V
R
R
H
P
----
D
S
----
H
L
K
L
W
V
I
A
Q
Q
H
P
G
E
H
M
A
E
W
F
M
E
G
L
I
E
R
L
----
Q
R
----
P
--
D
D
T
E
M
Q
R
L
L
E
K
A
D
L
Y
L
V
P
N
M
N
P
D
G
A
F
H
G
N
--------
L
--------
R
--------
T
--------
N
A
A
G
Q
D
L
N
R
A
W
L
E
------------------
P
-------------------
S
A
E
R
S
P
E
V
W
F
V
Q
Q
E
M
K
R
H
--
G
V
D
L
F
L
D
I
H
G
D
E
E
-
I
-
P
H
V
F
A
A
G
C
E
G
------
N
P
G
Y
T
P
R
L
E
R
L
E
Q
R
F
R
E
E
L
-
M
A
R
G
--
E
F
Q
I
R
H
G
Y
P
R
---------
S
A
P
---
G
---
Q
A
N
L
A
L
A
C
N
F
V
G
Q
T
Y
D
C
L
A
F
T
I
E
M
P
F
K
D
H
D
D
N
P
E
P
G
T
G
-
W
S
G
A
R
S
K
R
L
G
Q
D
V
L
S
T
L
A
V
L
V
D
E
L
R
2
PsiBlast_PDB
98.30
100%
-91
- C4 -
4A38
2
?
A:
[14-388]
M
Q
I
R
A
D
F
D
S
G
N
I
Q
V
I
D
A
S
D
P
R
R
I
R
L
A
I
R
P
D
L
A
S
Q
H
F
Q
W
F
H
F
K
V
E
G
M
A
P
A
T
E
H
C
F
-
T
L
V
N
A
G
Q
S
A
Y
S
H
A
W
S
G
Y
Q
A
V
A
S
Y
D
G
E
R
W
F
R
V
P
S
Q
Y
D
A
D
G
L
H
F
Q
L
E
P
E
E
S
E
V
R
F
A
Y
F
E
P
Y
S
R
E
R
H
A
R
L
V
E
R
A
L
G
-
I
E
-
G
V
E
R
L
A
V
G
T
S
V
Q
G
R
D
I
E
L
L
R
V
R
R
H
P
----
D
S
----
H
L
K
L
W
V
I
A
Q
Q
H
P
G
E
H
M
A
E
W
F
M
E
G
L
I
E
R
L
----
Q
R
----
P
--
D
D
T
E
M
Q
R
L
L
E
K
A
D
L
Y
L
V
P
N
M
N
P
D
G
A
F
H
G
N
--------
L
--------
R
--------
T
--------
N
A
A
G
Q
D
L
N
R
A
W
L
E
------------------
P
-------------------
S
A
E
R
S
P
E
V
W
F
V
Q
Q
E
M
K
R
H
--
G
V
D
L
F
L
D
I
H
G
D
E
E
-
I
-
P
H
V
F
A
A
G
C
E
G
------
N
P
G
Y
T
P
R
L
E
R
L
E
Q
R
F
R
E
E
L
-
M
A
R
G
--
E
F
Q
I
R
H
G
Y
P
R
---------
S
A
P
---
G
---
Q
A
N
L
A
L
A
C
N
F
V
G
Q
T
Y
D
C
L
A
F
T
I
E
M
P
F
K
D
H
D
D
N
P
E
P
G
T
G
-
W
S
G
A
R
S
K
R
L
G
Q
D
V
L
S
T
L
A
V
L
V
D
E
L
R
22
PsiBlast_CBE
98.12
100%
-92
- C4 -
4A38
1
?
B:
[14-388]
M
Q
I
R
A
D
F
D
S
G
N
I
Q
V
I
D
A
S
D
P
R
R
I
R
L
A
I
R
P
D
L
A
S
Q
H
F
Q
W
F
H
F
K
V
E
G
M
A
P
A
T
E
H
C
F
-
T
L
V
N
A
G
Q
S
A
Y
S
H
A
W
S
G
Y
Q
A
V
A
S
Y
D
G
E
R
W
F
R
V
P
S
Q
Y
D
A
D
G
L
H
F
Q
L
E
P
E
E
S
E
V
R
F
A
Y
F
E
P
Y
S
R
E
R
H
A
R
L
V
E
R
A
L
G
-
I
E
-
G
V
E
R
L
A
V
G
T
S
V
Q
G
R
D
I
E
L
L
R
V
R
R
H
P
----
D
S
----
H
L
K
L
W
V
I
A
Q
Q
H
P
G
E
H
M
A
E
W
F
M
E
G
L
I
E
R
L
----
Q
R
----
P
--
D
D
T
E
M
Q
R
L
L
E
K
A
D
L
Y
L
V
P
N
M
N
P
D
G
A
F
H
G
N
--------
L
--------
R
--------
T
--------
N
A
A
G
Q
D
L
N
R
A
W
L
E
------------------
P
-------------------
S
A
E
R
S
P
E
V
W
F
V
Q
Q
E
M
K
R
H
--
G
V
D
L
F
L
D
I
H
G
D
E
E
-
I
-
P
H
V
F
A
A
G
C
E
G
------
N
P
G
Y
T
P
R
L
E
R
L
E
Q
R
F
R
E
E
L
-
M
A
R
G
--
E
F
Q
I
R
H
G
Y
P
R
---------
S
A
P
---
G
---
Q
A
N
L
A
L
A
C
N
F
V
G
Q
T
Y
D
C
L
A
F
T
I
E
M
P
F
K
D
H
D
D
N
P
E
P
G
T
G
-
W
S
G
A
R
S
K
R
L
G
Q
D
V
L
S
T
L
A
V
L
V
D
E
L
R
30
HHSearch
81.49
44%
-91
* C4 *
3L2N
4
?
A:
[20-393]
M
R
I
S
A
N
F
D
G
G
N
I
E
T
I
S
L
A
N
P
D
D
I
Q
L
A
I
R
P
D
A
G
G
E
F
Y
Q
W
F
N
F
R
F
E
A
T
-
I
G
K
T
Y
T
L
-
N
I
L
N
A
G
G
A
S
Y
L
K
G
W
E
D
Y
Q
A
V
A
S
Y
D
R
Q
T
W
F
R
L
P
T
E
Y
K
D
G
K
L
S
I
S
V
E
L
D
C
E
A
I
Q
I
A
Y
F
T
P
Y
S
Y
E
R
H
L
D
L
I
S
A
V
Q
L
-
H
P
-
L
V
S
T
E
H
L
G
L
T
L
D
G
R
D
M
T
L
V
K
V
G
D
D
D
----
P
S
----
K
K
S
I
W
I
T
A
R
Q
H
P
G
E
T
M
A
E
W
L
V
E
G
L
L
N
Q
L
----
L
D
----
N
--
D
C
P
T
S
K
A
L
L
D
K
A
N
F
Y
I
V
P
N
M
N
P
D
G
S
V
R
G
H
--------
L
--------
R
--------
T
--------
N
A
V
G
A
N
L
N
R
E
W
Q
T
------------------
P
-------------------
S
L
E
R
S
P
E
V
Y
Y
V
V
N
K
M
H
E
T
--
G
V
D
L
F
Y
D
V
H
G
D
E
G
-
L
-
P
Y
V
F
L
A
G
C
E
G
------
I
P
N
Y
S
D
K
L
A
S
L
Q
Q
D
F
V
A
A
L
-
S
L
A
S
A-
D
F
Q
T
E
F
G
Y
D
K
---------
D
E
P
---
G
---
K
A
N
L
T
V
A
C
N
W
V
A
N
T
F
K
C
L
S
N
T
L
E
M
P
F
K
D
N
A
N
-
L
A
D
P
F
Q
G
W
S
P
E
R
S
V
Y
F
G
E
A
S
L
I
A
M
R
A
V
I
D
K
I
-
5
PsiBlast_PDB
81.43
41%
-90
- C4 -
4B6Z
5
?
A:
[24-404]
L
S
I
T
S
N
F
D
A
G
A
I
D
V
V
S
C
D
S
P
D
A
I
R
L
R
V
R
G
D
N
R
S
E
F
A
Q
W
F
Y
Y
R
L
T
G
-
A
R
G
E
R
C
V
M
-
T
F
E
N
A
A
E
C
A
Y
P
S
G
W
R
N
Y
S
A
V
A
S
Y
D
R
V
D
W
F
R
V
P
T
T
F
D
G
K
T
M
T
I
D
H
T
P
E
F
D
S
I
Y
Y
A
Y
F
E
P
Y
S
E
E
R
H
A
A
F
L
G
A
V
Q
Q
-
L
P
-
Q
A
S
V
V
E
L
G
R
T
V
E
G
R
P
M
S
L
L
T
L
G
T
-
P
----
E
T
AP--
K
K
K
V
W
I
I
A
R
Q
H
P
G
E
S
M
A
E
W
F
V
E
G
L
V
K
R
L
----
A
G
WGDW
A
--
G
D
P
V
A
R
K
L
Y
D
R
V
T
F
H
I
V
P
N
M
N
P
D
G
S
V
H
G
N
--------
L
--------
R
--------
T
--------
N
A
A
G
A
N
L
N
R
E
W
M
A
------------------
P
-------------------
D
A
E
R
S
P
E
V
L
A
V
R
D
A
I
H
A
I
--
G
C
D
M
F
F
D
I
H
G
D
E
D
-
L
-
P
Y
V
F
V
A
G
S
E
M
------
L
P
S
F
T
E
Q
Q
G
K
E
Q
T
A
F
I
E
A
F
K
V
A
S
P
--
D
F
Q
T
E
H
G
Y
A
A
---------
S
K
Y
---
K
---
E
D
A
L
K
L
A
S
K
Y
I
G
H
Q
F
G
C
L
S
L
T
L
E
M
P
F
K
D
N
A
N
L
P
D
E
R
V
G
-
W
N
G
E
R
S
A
A
L
G
A
A
M
L
A
A
I
L
V
H
V
D
T
F
-
26
PsiBlast_CBE
81.01
41%
-90
- C4 -
4B6Z
7
?
B:
[24-404]
L
S
I
T
S
N
F
D
A
G
A
I
D
V
V
S
C
D
S
P
D
A
I
R
L
R
V
R
G
D
N
R
S
E
F
A
Q
W
F
Y
Y
R
L
T
G
-
A
R
G
E
R
C
V
M
-
T
F
E
N
A
A
E
C
A
Y
P
S
G
W
R
N
Y
S
A
V
A
S
Y
D
R
V
D
W
F
R
V
P
T
T
F
D
G
K
T
M
T
I
D
H
T
P
E
F
D
S
I
Y
Y
A
Y
F
E
P
Y
S
E
E
R
H
A
A
F
L
G
A
V
Q
Q
-
L
P
-
Q
A
S
V
V
E
L
G
R
T
V
E
G
R
P
M
S
L
L
T
L
G
T
-
P
----
E
T
DGAP
K
K
K
V
W
I
I
A
R
Q
H
P
G
E
S
M
A
E
W
F
V
E
G
L
V
K
R
L
----
A
G
WGDW
A
--
G
D
P
V
A
R
K
L
Y
D
R
V
T
F
H
I
V
P
N
M
N
P
D
G
S
V
H
G
N
--------
L
--------
R
--------
T
--------
N
A
A
G
A
N
L
N
R
E
W
M
A
------------------
P
-------------------
D
A
E
R
S
P
E
V
L
A
V
R
D
A
I
H
A
I
--
G
C
D
M
F
F
D
I
H
G
D
E
D
-
L
-
P
Y
V
F
V
A
G
S
E
M
------
L
P
S
F
T
E
Q
Q
G
K
E
Q
T
A
F
I
E
A
F
K
V
A
S
P
--
D
F
Q
T
E
H
G
Y
A
A
---------
S
-
Y
---
K
---
E
D
A
L
K
L
A
S
K
Y
I
G
H
Q
F
G
C
L
S
L
T
L
E
M
P
F
K
D
N
A
N
L
P
D
E
R
V
G
-
W
N
G
E
R
S
A
A
L
G
A
A
M
L
A
A
I
L
V
H
V
D
T
F
-
4
PsiBlast_PDB
80.95
43%
-89
- C4 -
3L2N
4
?
A:
[21-393]
-
R
I
S
A
N
F
D
G
G
N
I
E
T
I
S
L
A
N
P
D
D
I
Q
L
A
I
R
P
D
A
G
G
E
F
Y
Q
W
F
N
F
R
F
E
A
T
I
G
K
T
-
Y
T
L
-
N
I
L
N
A
G
G
A
S
Y
L
K
G
W
E
D
Y
Q
A
V
A
S
Y
D
R
Q
T
W
F
R
L
P
T
E
Y
K
D
G
K
L
S
I
S
V
E
L
D
C
E
A
I
Q
I
A
Y
F
T
P
Y
S
Y
E
R
H
L
D
L
I
S
A
V
Q
L
-
H
P
-
L
V
S
T
E
H
L
G
L
T
L
D
G
R
D
M
T
L
V
K
V
G
D
D
D
----
P
S
----
K
K
S
I
W
I
T
A
R
Q
H
P
G
E
T
M
A
E
W
L
V
E
G
L
L
N
Q
L
----
L
D
----
N
--
D
C
P
T
S
K
A
L
L
D
K
A
N
F
Y
I
V
P
N
M
N
P
D
G
S
V
R
G
H
--------
L
--------
R
--------
T
--------
N
A
V
G
A
N
L
N
R
E
W
Q
T
------------------
P
-------------------
S
L
E
R
S
P
E
V
Y
Y
V
V
N
K
M
H
E
T
--
G
V
D
L
F
Y
D
V
H
G
D
E
G
-
L
-
P
Y
V
F
L
A
G
C
E
G
------
I
P
N
Y
S
D
K
L
A
S
L
Q
Q
D
F
V
A
A
L
S
L
A
S
A
--
D
F
Q
T
E
F
G
Y
D
K
---------
D
E
P
---
G
---
K
A
N
L
T
V
A
C
N
W
V
A
N
T
F
K
C
L
S
N
T
L
E
M
P
F
K
D
N
A
N
L
A
D
P
F
Q
G
-
W
S
P
E
R
S
V
Y
F
G
E
A
S
L
I
A
M
R
A
V
I
D
K
I
-
25
PsiBlast_CBE
80.18
41%
-87
- C4 -
4B6Z
12
?
C:
[24-404]
L
S
I
T
S
N
F
D
A
G
A
I
D
V
V
S
C
D
S
P
D
A
I
R
L
R
V
R
G
D
N
R
S
E
F
A
Q
W
F
Y
Y
R
L
T
G
-
A
R
G
E
R
C
V
M
-
T
F
E
N
A
A
E
C
A
Y
P
S
G
W
R
N
Y
S
A
V
A
S
Y
D
R
V
D
W
F
R
V
P
T
T
F
D
G
K
T
M
T
I
D
H
T
P
E
F
D
S
I
Y
Y
A
Y
F
E
P
Y
S
E
E
R
H
A
A
F
L
G
A
V
Q
Q
-
L
P
-
Q
A
S
V
V
E
L
G
R
T
V
E
G
R
P
M
S
L
L
T
L
G
T
-
P
----
E
T
AP--
K
K
K
V
W
I
I
A
R
Q
H
P
G
E
S
M
A
E
W
F
V
E
G
L
V
K
R
L
----
A
G
W
GDW
A
--
G
D
P
V
A
R
K
L
Y
D
R
V
T
F
H
I
V
P
N
M
N
P
D
G
S
V
H
G
N
--------
L
--------
R
--------
T
--------
N
A
A
G
A
N
L
N
R
E
W
M
A
------------------
P
-------------------
D
A
E
R
S
P
E
V
L
A
V
R
D
A
I
H
A
I
--
G
C
D
M
F
F
D
I
H
G
D
E
D
-
L
-
P
Y
V
F
V
A
G
S
E
M
------
L
P
S
F
T
E
Q
Q
G
K
E
Q
T
A
F
I
E
A
F
K
V
A
S
P
--
D
F
Q
T
E
H
G
--------------
Y
---
K
---
E
D
A
L
K
L
A
S
K
Y
I
G
H
Q
F
G
C
L
S
L
T
L
E
M
P
F
K
D
N
A
N
L
P
D
E
R
V
G
-
W
N
G
E
R
S
A
A
L
G
A
A
M
L
A
A
I
L
V
H
V
D
T
F
-
24
PsiBlast_CBE
80.03
41%
-87
- C4 -
4B6Z
8
?
D:
[24-404]
L
S
I
T
S
N
F
D
A
G
A
I
D
V
V
S
C
D
S
P
D
A
I
R
L
R
V
R
G
D
N
R
S
E
F
A
Q
W
F
Y
Y
R
L
T
G
-
A
R
G
E
R
C
V
M
-
T
F
E
N
A
A
E
C
A
Y
P
S
G
W
R
N
Y
S
A
V
A
S
Y
D
R
V
D
W
F
R
V
P
T
T
F
D
G
K
T
M
T
I
D
H
T
P
E
F
D
S
I
Y
Y
A
Y
F
E
P
Y
S
E
E
R
H
A
A
F
L
G
A
V
Q
Q
-
L
P
-
Q
A
S
V
V
E
L
G
R
T
V
E
G
R
P
M
S
L
L
T
L
G
T
-
P
----
E
T
DGAP
K
K
K
V
W
I
I
A
R
Q
H
P
G
E
S
M
A
E
W
F
V
E
G
L
V
K
R
L
----
A
G
WGDW
A
--
G
D
P
V
A
R
K
L
Y
D
R
V
T
F
H
I
V
P
N
M
N
P
D
G
S
V
H
G
N
--------
L
--------
R
--------
T
--------
N
A
A
G
A
N
L
N
R
E
W
M
A
------------------
P
-------------------
D
A
E
R
S
P
E
V
L
A
V
R
D
A
I
H
A
I
--
G
C
D
M
F
F
D
I
H
G
D
E
D
-
L
-
P
Y
V
F
V
A
G
S
E
M
------
L
P
S
F
T
E
Q
Q
G
K
E
Q
T
A
F
I
E
A
F
K
V
A
S
P
--
D
F
Q
T
E
H
G
Y
-------------
Y
---
K
---
E
D
A
L
K
L
A
S
K
Y
I
G
H
Q
F
G
C
L
S
L
T
L
E
M
P
F
K
D
N
A
N
L
P
D
E
R
V
G
-
W
N
G
E
R
S
A
A
L
G
A
A
M
L
A
A
I
L
V
H
V
D
T
F
-
6
PsiBlast_PDB
73.55
43%
-79
- C4 -
3K2K
5
?
A:
[22-395]
L
S
I
T
S
N
F
D
A
G
A
I
D
V
V
S
C
E
R
A
D
A
I
R
L
R
V
R
G
D
N
R
S
E
F
A
Q
W
F
Y
F
R
L
T
G
A
R
--
G
E
R
C
V
M
T
F
E
N
A
N
D
C
A
Y
P
A
G
W
R
D
Y
R
A
V
A
S
Y
D
R
V
N
W
F
R
V
P
T
S
Y
D
G
Q
M
L
T
I
D
H
T
P
E
F
D
S
I
H
Y
A
Y
F
E
P
Y
S
E
E
R
H
S
E
F
L
G
A
V
Q
Q
-
M
P
-
Q
A
S
V
V
E
L
G
R
T
V
E
G
R
P
M
S
L
V
-
V
L
G
T
P
----
D
A
----
K
K
K
V
W
I
I
A
R
Q
H
P
G
E
S
M
A
E
W
F
I
E
G
L
V
K
R
L
V
GWG
D
W
----
S
--
G
D
P
V
A
R
K
L
Y
D
H
A
T
F
Y
I
V
P
N
M
N
P
D
G
S
V
H
G
N
--------
L
--------
R
--------
T
--------
N
A
A
G
A
N
L
N
R
E
W
M
E
------------------
P
-------------------
D
A
E
R
S
P
E
V
L
V
V
R
D
A
I
H
A
I
--
G
C
D
L
F
F
D
I
H
G
D
E
D
-
L
-
P
Y
V
F
A
A
G
S
E
M
------
L
P
G
F
T
E
Q
-
Q
R
V
E
Q
S
A
F
I
D
S
-
F
K
R
A
SP
D
F
Q
D
E
H
G
Y
P
P
---------
G
K
Y
---
R
---
E
D
A
F
K
L
A
S
K
Y
I
G
H
R
F
G
C
L
S
L
T
L
E
M
P
F
K
D
N
A
N
L
P
D
E
H
I
G
-
W
N
G
A
R
S
A
S
L
G
A
A
M
L
G
A
I
--------
31
HHSearch
58.62
18%
-72
- C4 -
1AYE
1
CBPA2_HUMAN
A:
[100-397]
-----------------------------------------------------------------------------------------------------------
F
N
F
G
A
Y
H
T
L
E
E
I
S
Q
E
M
D
N
L
V
A
E
H
P
G
L
V
S
K
V
N
I
G
S
S
F
E
N
R
P
M
N
V
L
K
F
S
T
G
-----
G
D
----
K
P
A
I
W
L
D
A
G
I
H
A
R
E
W
V
T
Q
A
T
A
L
W
T
A
N
K
I
----
V
S
----
D
YG
K
D
P
S
I
T
S
I
L
D
A
L
D
I
F
L
L
P
V
T
N
P
D
G
Y
V
F
S
Q
T
KNRM---
W
--------
R
KTRSKVSG
S
--------
L
C
V
G
V
D
P
N
R
N
W
D
A
GFGGPGASSNPCSDSYHG
P
-------------------
S
A
N
S
E
V
E
V
K
S
I
V
D
F
I
K
S
H
G-
K
V
K
A
F
I
I
L
H
S
Y
S
Q
-
L
L
M
F
P
Y
G
Y
K
C
T
K
------
L
D
D
-
F
D
E
L
S
E
V
A
Q
K
A
A
Q
S
L
-
R
S
L
H
------
G
T
K
Y
K
V
---------
G
P
I
---
C
SVI
Y
Q
A
S
G
G
S
I
D
W
S
Y
D
Y
G
I
K
Y
S
F
A
F
E
L
R
D
T
G
-----
R
Y
G
F
L
-
L
P
A
R
Q
I
L
P
T
A
E
E
T
W
L
G
L
K
A
I
M
E
H
V
R
36
HHSearch
57.55
18%
-68
- C4 -
1DTD
2
CBPA2_HUMAN
A:
[1-299]
-----------------------------------------------------------------------------------------------------------
F
N
F
G
A
Y
H
T
L
E
E
I
S
Q
E
M
D
N
L
V
A
E
H
P
G
L
V
S
K
V
N
I
G
S
S
F
E
N
R
P
M
N
V
L
K
F
S
T
G
-----
G
D
----
K
P
A
I
W
L
D
A
G
I
H
A
R
E
W
V
T
Q
A
T
A
L
W
T
A
N
K
I
----
V
S
----
D
YG
K
D
P
S
I
T
S
I
L
D
A
L
D
I
F
L
L
P
V
T
N
P
D
G
Y
V
F
S
Q
--------
T
KNRMWRKT
R
SKVSAG--
S
--------
L
C
V
G
V
D
P
N
R
N
W
D
A
GFGGPGASSNPCSDSYHG
P
-------------------
S
A
N
S
E
V
E
V
K
S
I
V
D
F
I
K
S
H
G-
K
V
K
A
F
I
I
L
H
S
Y
S
Q
-
L
L
M
F
P
Y
G
Y
K
C
T
K
------
L
D
D
F
-
D
E
L
S
E
V
A
Q
K
A
A
Q
S
L
-
S
R
L
H
------
G
T
K
Y
K
V
---------
G
P
I
---
C
SVI
Y
Q
A
S
G
G
S
I
D
W
S
Y
D
Y
G
I
K
Y
S
F
A
F
E
L
R
D
T
G
-----
R
Y
G
F
L
-
L
P
A
R
Q
I
L
P
T
A
E
E
T
W
L
G
L
K
A
I
M
E
H
V
R
33
HHSearch
55.94
15%
-69
- C4 -
1PCA
2
CBPA1_PIG
A:
[101-399]
----------------------------------------------------------------------------------------------------------
T
F
N
Y
A
T
Y
H
T
L
E
E
I
Y
D
F
M
D
I
L
V
A
E
H
P
A
L
V
S
K
L
Q
I
G
R
S
Y
E
G
R
P
I
Y
V
L
K
F
S
T
G
G
----
S
N
----
R
P
A
I
W
I
D
S
G
I
H
S
R
E
W
I
T
Q
A
S
G
V
W
F
A
K
K
I
----
T
E
----
N
YG
Q
N
S
S
F
T
A
I
L
D
S
M
D
I
F
L
E
I
V
T
N
P
N
G
F
A
F
T
H
S
DNRL---
W
--------
R
KTRSKASG
S
--------
L
C
V
G
S
D
S
N
R
N
W
D
A
GFGGAGASSSPCAETYHG
K
-------------------
Y
P
N
S
E
V
E
V
K
S
I
T
D
F
V
K
N
N
G-
N
I
K
A
F
I
S
I
H
S
Y
S
Q
-
L
L
L
Y
P
Y
G
Y
K
T
Q
S
------
P
A
D
-
K
S
E
L
N
Q
I
A
K
S
A
V
A
A
L
-
K
S
L
Y
------
G
T
S
Y
K
Y
---------
G
S
I
---
I
TVI
Y
Q
A
S
G
G
V
I
D
W
T
Y
N
Q
G
I
K
Y
S
F
S
F
E
L
R
D
T
G
-----
R
R
G
F
L
-
L
P
A
S
Q
I
I
P
T
A
Q
E
T
W
L
A
L
L
T
I
M
E
H
T
-
34
HHSearch
55.64
17%
-71
- C4 -
1KWM
2
CBPB1_HUMAN
A:
[99-398]
-----------------------------------------------------------------------------------------------------------
H
S
Y
E
K
Y
N
K
W
E
T
I
E
A
W
T
Q
Q
V
A
T
E
N
P
A
L
I
S
R
S
V
I
G
T
T
F
E
G
R
A
I
Y
L
L
K
V
G
K
A
G
----
Q
N
----
K
P
A
I
F
M
D
C
G
F
H
A
R
E
W
I
S
P
A
F
C
Q
W
F
V
R
E
A
----
V
R
----
T
YG
R
E
I
Q
V
T
E
L
L
N
K
L
D
F
Y
V
L
P
V
L
N
I
D
G
Y
I
Y
T
W
T
KSRF---
W
--------
R
KTRSTHTG
S
--------
S
C
I
G
T
D
P
N
R
N
F
D
A
GWCEIGASRNPCDETYCG
P
-------------------
A
A
E
S
E
K
E
T
K
A
L
A
D
F
I
R
N
K
LS
S
I
K
A
Y
L
T
I
H
S
Y
S
Q
-
M
M
I
Y
P
Y
S
Y
A
Y
K
L
------
G
E
N
-
N
A
E
L
N
A
L
A
K
A
T
V
K
E
L
-
A
S
L
H
------
G
T
K
Y
T
Y
---------
G
P
G
---
A
TTI
Y
P
A
A
G
G
S
D
D
W
A
Y
D
Q
G
I
R
Y
S
F
T
F
E
L
R
D
T
G
-----
R
Y
G
F
L
-
L
P
E
S
Q
I
R
A
T
C
E
E
T
F
L
A
I
K
Y
V
A
S
Y
V
L
39
HHSearch
55.49
17%
-77
- C4 -
3D4U
8
CBPB2_BOVIN
A:
[5-305]
------------------------------------------------------------------------------------------------------------
Y
Y
E
Q
Y
H
S
L
N
E
I
Y
S
W
I
E
V
M
T
E
R
Y
P
D
M
V
E
K
I
H
I
G
S
S
Y
E
K
Y
P
L
Y
V
L
K
V
S
K
K
------------
N
A
M
W
I
D
C
G
I
H
A
R
E
W
I
S
P
A
F
C
L
W
F
V
G
S
V
----
T
Y
----
Y
YG
K
-----
N
L
L
K
H
M
D
F
Y
I
M
P
V
V
N
V
D
G
Y
D
Y
T
W
KKDRM---
W
--------
R
--------
K
N
R
S
L
H
EKN
A
C
V
G
T
D
L
N
R
N
F
A
S
------------------
K
HWCGEGASSSSCSEIYCGT
Y
P
E
S
E
P
E
V
K
A
V
A
D
F
L
R
R
N
IK
H
I
K
A
Y
I
S
M
H
S
Y
S
Q
K
I
-
V
F
P
Y
S
Y
S
R
S
R
------
S
K
D
H
-
E
E
L
S
L
V
A
R
E
A
V
F
A
M
-
E
N
I
H
-----
R
N
I
R
Y
T
H
---------
G
S
G
---
S
ESL
Y
L
A
P
G
G
S
D
D
W
I
Y
D
L
G
I
K
Y
S
F
T
F
E
L
R
D
K
G
-----
K
Y
G
F
L
-
L
P
E
S
Y
I
R
P
T
C
S
E
A
L
V
A
V
A
K
I
A
S
H
V
-
44
HHSearch
55.31
20%
-72
- C4 -
1H8L
4
CBPD_LOPSP
A:
[10-297]
----------------------------------------------------------------------------------------------------------------
H
H
H
F
S
D
M
E
I
F
L
R
R
Y
A
N
E
Y
P
S
I
T
R
L
Y
S
V
G
K
S
V
E
L
R
E
L
Y
V
M
E
I
S
D
N
P
GIHE
A
G
----
E
P
E
F
K
Y
I
G
N
M
H
G
N
E
V
V
G
R
E
L
L
L
N
L
I
E
Y
L
----
C
K
----
N
FG
T
D
P
E
V
T
D
L
V
Q
S
T
R
I
H
I
M
P
S
M
N
P
D
G
Y
E
K
S
Q
EGDRGGTV
G
--------
R
--------
N
--------
N
S
N
N
Y
D
L
N
R
N
F
P
D
------------------
Q
FFQV---------------
T
D
P
P
Q
P
E
T
L
A
V
M
S
W
L
K
T
Y
--
P
F
V
L
S
A
N
L
H
G
G
S
L
V
V
-
N
Y
P
F
D
D
D
E
Q
G
IA
I
Y
S
K
S
P
D
-
D
A
V
F
Q
Q
L
A
L
S
Y
S
K
E
N
-
K
K
M
Y
Q
-
G
S
P
C
K
D
L
Y
P
T
E
Y
F
P
HGITN
G
A
Q
---
W
---
Y
N
V
P
G
G
M
Q
D
W
N
Y
L
N
T
N
C
F
E
V
T
I
E
L
G
C
V
K
Y
----------
P
K
A
E
E
L
P
K
Y
W
E
Q
N
R
R
S
L
L
Q
F
I
K
---
35
HHSearch
54.35
17%
-66
- C4 -
1M4L
1
CBPA1_BOVIN
A:
[5-304]
---------------------------------------------------------------------------------------------------------
N
T
F
N
Y
A
T
Y
H
T
L
D
E
I
Y
D
F
M
D
L
L
V
A
E
H
P
Q
L
V
S
K
L
Q
I
G
R
S
Y
E
G
R
P
I
Y
V
L
K
F
S
T
G
G
----
S
N
----
R
P
A
I
W
I
D
L
G
I
H
S
R
E
W
I
T
Q
A
T
G
V
W
F
A
K
K
F
----
T
E
----
D
YG
Q
D
P
S
F
T
A
I
L
D
S
M
D
I
F
L
E
I
V
T
N
P
D
G
F
A
F
T
H
S
QNRL---
W
--------
R
KTRSVTSS
S
--------
L
C
V
G
V
D
A
N
R
N
W
D
A
------------------
G
FGKAGASSSPCSETYHGK-
Y
A
N
S
E
V
E
V
K
S
I
V
D
F
V
K
D
H
G-
N
F
K
A
F
L
S
I
H
S
Y
S
Q
-
L
L
L
Y
P
Y
G
Y
T
T
Q
S
------
I
P
D
K
-
T
E
L
N
Q
V
A
K
S
A
V
A
A
L
-
K
S
L
Y
------
G
T
S
Y
K
Y
---------
G
S
I
ITT
I
---
Y
Q
A
S
G
G
S
I
D
W
S
Y
N
Q
G
I
K
Y
S
F
T
F
E
L
R
D
T
G
-----
R
Y
G
F
L
-
L
P
A
S
Q
I
I
P
T
A
Q
E
T
W
L
G
V
L
T
I
M
E
H
T
-