@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2840: (2016-02-11 )
MGLCGCIRGKPMTQETVGFAALGIHPNVLAAIVAVGYEEPSPIQAQSIPLILEGHDMIGQAQTGTGKTAAFALPLLSRIDPSRREPQMLVLVPTRELALQVATACETYSKQLPGVGVVAVYGGAPMGPQLKALRQGAQILVATPGRLCDHLRRDEKLLATVQRLVLDEADEMLKLGFMDDLEVIFEALPESRQTVLFSATLPASIRGIAERHLKQPKHVKIAAKTQTVARIEQVHLMVHADQKAGSIQRLLEVEQFDALIAFVRTKQATLDYAELLERQGYRAAALNGDMPQAQRERVIESLKDGSLDIVIATDVAARGLDVPRITHVLNIDMPYDPESYVHRIGRTGRAGREGRALLLVTPRERRMLQVIERVTGQKVGEVRLPDAETVLEARLARLAASLTPLLDSAVEQRGAVRDELCRRLGCDAETLAAALLARLTAGKALDLESVRREQPLTPSAPRERADRGERGERPERSGERRPMAPPSEGRARCRTALGARDGVAAKNLLGAILNEGGLSREDIGRIQIRDTFSLIELPEANLERLLTKLKDTRVAGKALRLRRYRED
Atome Classification :
(80 SA)
.........10........20........30........40........50.--.--.--.....60........70......---..--80-..------------------.-------..---..-..90---.........100.-----......110.---..---..------..120.......130.-..-..-..140.......150.----.-..--.-..160........170.---..-.-...180--....--..----.-------190-----.--.-------.......200.......210.....--..220..----..-...--230.......240-.-..----..----.--------..250-.--......-260.....-..270.......---280---.......290.......300.......310.......320.......330...------..------..340.......350.......360.-.-.-....370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGLCGCIRGKPMTQETV
G
F
A
A
LGI
H
P
N
V
L
A
A
I
V
A
VGYEEPSPIQAQS
I
P
L
I
L
--E--G--HDMIGQAQTGTGK
T
A
A
F
A
L
P
L
L
S
---RI--D--PS------------------R-------RE---
P
Q
-
M
L
V
----
L
VP
T
R
E
L
A
L
Q
V
A
T
-----
A
C
E
T
Y
S
K
QLP---G
V
---
G
V
------
V
A
V
YGGAPM
G
P
Q
L
K
A
L
-RQ-G
A
-
Q
I
L
V
AT
P
G
R
L
C
D
H
L
R
R
----
D
-
E
K
--
L
-
L
A
T
-
V
Q
R
L
V
L
D
E
A
D
E
M
L
---
K
L-G-
F
M
D
D
L
E
--
V
I
F
E
--AL----P-------E-------S--R-------
Q
T
V
L
F
SATL
P
A
S
I
R
G
I
A
E
R
HLKQP
K
--
H
V
K
I
A
AK----
T
Q
-
T
V
A
--
R
I
E
Q
V
H
L
M
V
H
A-D-Q-KA----
G
S
----
I
--------
Q
R
L
L
E
-
V
--
E
Q
F
D
A
L
-
I
A
F
V
R
TKQ-A
T
L
D
Y
A
E
L
L
E
RQ---G
Y
R
---
A
AALNGDM
P
Q
A
Q
R
E
R
V
I
E
S
L
KDG
S
L
D
I
V
I
AT
D
V
A
ARGLDVP
R
I
T
H
V
L
NIDMPY------D
P
------
E
S
Y
V
H
R
IGRTGRAGREG
R
A
L
L
L
VTP
R
-
E
-
R
-
R
M
L
Q
V
I
E
R
V
TGQKVG
E
V
RLP
D
A
E
T
V
L
E
A
R
L
A
R
L
A
A
S
L
T
P
L
L
D
S
A
V
E
Q
RG
A
V
R
D
E
L
C
R
RLGC
D
A
E
T
L
A
A
A
L
L
A
R
L
TAGKAL
D
L
E
S
V
RREQPLTPSA
P
R
E
RADRGERGERPERSGERRPMAPPSE
G
R
A
R
C
R
T
ALGARD
G
V
A
A
K
N
L
L
G
A
I
L
NEGGL
S
R
E
DI
G
R
I
Q
I
R
D
T
FSLIEL
P
E
A
N
L
E
R
L
L
T
K
L
K
DTRVA
G
K
A
L
R
L
R
R
YRED
21
PsiBlast_CBE
88.77
46%
-104
- C3 -
4KBG
4
?
B:
[3-364]
------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
--
A
--
P
S
------------------
Q
ERG----
R
K
---
P
R
-
A
L
V
----
L
T
P
T
R
E
L
A
L
Q
V
A
S
-----
E
L
T
A
V
A
---
P
---
H
L
---
K
V
------
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
-
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
----
G
-
V
L
--
D
-
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
--
A
L
L
S
--
A
T
----
P
-------
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
--
L
I
N
V
I
K
D
----
E
P
-
V
T
Y
--
E
E
E
A
V
P
A
P
V
R
G
-----
R
L
----
E
V
----
L
--------
S
D
L
L
Y
-
V
--
A
S
P
D
R
A
-
M
V
F
T
R
T
K
A
-
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
---
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
------
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
-
E
-
R
-
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.73
46%
-100
- C3 -
4KBF
3
?
A:
[3-364]
------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
--
A
--
P
S
------------------
Q
ERG----
R
K
---
P
R
-
A
L
V
----
L
T
P
T
R
E
L
A
L
Q
V
A
S
-----
E
L
T
A
V
A
---
P
---
H
L
---
K
V
------
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
-
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
----
G
-
V
L
--
D
-
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
--
A
L
L
S
--
A
T
----
P
-------
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
--
L
I
N
V
I
K
D
----
E
P
-
V
T
Y
--
E
E
E
A
V
P
A
P
V
R
G
-----
R
L
----
E
V
----
L
--------
S
D
L
L
Y
-
V
--
A
S
P
D
R
A
-
M
V
F
T
R
T
K
A
-
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
---
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
------
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
-
E
-
R
-
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
87.88
46%
-109
- C3 -
4KBF
1
?
B:
[3-364]
------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
--
A
--
P
S
------------------
Q
ERG----
R
K
---
P
R
-
A
L
V
----
L
T
P
T
R
E
L
A
L
Q
V
A
S
-----
E
L
T
A
V
A
---
P
---
H
L
---
K
V
------
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
-
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
----
G
-
V
L
--
D
-
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
--
A
L
L
S
--
A
T
----
P
-------
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
--
L
I
N
V
I
K
D
----
E
P
-
V
T
Y
--
E
E
E
A
V
P
A
P
V
R
G
-----
R
L
----
E
V
----
L
--------
S
D
L
L
Y
-
V
--
A
S
P
D
R
A
-
M
V
F
T
R
T
K
A
-
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
---
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
------
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
-
E
-
R
-
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
86.42
37%
-104
- C3 -
2I4I
1
DDX3X_HUMAN
A:
[7-394]
--------
G
N
N
C
P
P
H
I
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
--
Y
--
S
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
-------
Q
Y
---
P
I
-
S
L
V
----
L
A
P
T
R
E
L
A
V
Q
I
Y
E
-----
E
A
R
K
F
S
Y
R
-
S
---
R
V
---
R
P
------
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
-
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
----
G
-
K
I
--
G
-
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
E
P
Q
I
R
--
R
I
V
E
--
Q
D
TMPP
K
-------
G
-------
V
--
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
--
F
L
A
V
G
---------
T
S
E
--
N
I
T
Q
K
V
V
W
V
E
E
-
S
-
D
-
K
R
----
S
F
----
L
--------
L
D
L
L
N
-
A
T-
G
K
D
S
L
T
-
L
V
F
V
E
T
K
K
-
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
---
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
-
N
-
I
-
N
I
T
K
D
L
L
D
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
86.16
36%
-93
- C3 -
2DB3
3
VASA1_DROME
A:
[48-419]
--------
G
S
D
V
P
Q
P
I
Q
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
K
L
--
L
--
E
D
------------------
P
H
E
L
E
L
--
G
R
---
P
Q
-
V
V
I
----
V
S
P
T
R
E
L
A
I
Q
I
F
N
-----
E
A
R
K
F
A
F
E
-
S
---
Y
L
---
K
I
------
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
I
-
T
R
-
G
C
-
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
----
T
-
F
I
--
T
-
F
E
D
-
T
R
F
V
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
S
E
D
M
R
--
R
I
M
T
--
H
V
----
T
MR-----
P
-------
E
--
H
-------
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
--
F
V
A
I
G
I
V
----
G
G
-
A
C
S
--
D
V
K
Q
T
I
Y
E
V
N
K
-
Y
-
A
-
K
R
----
S
K
----
L
--------
I
E
I
L
S
-
E
---
Q
A
D
G
T
-
I
V
F
V
E
T
K
R
-
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
---
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
------
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
D
-
R
-
A
I
A
A
D
L
V
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.59
34%
-100
- C3 -
2J0S
3
IF4A3_HUMAN
A:
[39-410]
------------------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
--
D
--
I
Q
------------------
V
-------
R
E
---
T
Q
-
A
L
I
----
L
A
P
T
R
E
L
A
V
Q
I
Q
K
-----
G
L
L
A
L
G
D
Y
M
----
N
V
---
Q
C
------
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
-
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
----
R
-
S
L
--
R
-
T
R
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
K
E
Q
I
Y
--
D
V
Y
R
--
Y
L
----
P
-------
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
--
R
I
L
V
K
R
D
----
E
L
-
T
L
E
--
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
W
K
F
----
D
T
----
L
--------
C
D
L
Y
D
-
T
--
L
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
-
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
---
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
-
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
M
P
M
N
V
A
D
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.49
34%
-100
- C3 -
2HYI
3
IF4A3_HUMAN
C:
[40-413]
------------------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
--
D
--
I
Q
------------------
V
-------
R
E
---
T
Q
-
A
L
I
----
L
A
P
T
R
E
L
A
V
Q
I
Q
K
-----
G
L
L
A
L
G
D
Y
M
----
N
V
---
Q
C
------
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
-
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
----
R
-
S
L
--
R
-
T
R
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
K
E
Q
I
Y
--
D
V
Y
R
--
Y
L
----
P
-------
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
--
R
I
L
V
K
R
D
----
E
L
-
T
L
E
--
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
W
K
F
----
D
T
----
L
--------
C
D
L
Y
D
-
T
--
L
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
-
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
---
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
-
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
M
P
M
N
V
A
D
L
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.27
40%
-113
- C3 -
1HV8
5
H669_METJA
A:
[4-355]
--------------
E
Y
M
N
F
N
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
--
N
--
D
E-
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
---
L
V
--
N
--
E
N
------------------
N
--------
G
---
I
E
-
A
I
I
----
L
T
P
T
R
E
L
A
I
Q
V
A
D
-----
E
I
E
S
L
-
K
G
N
K
---
N
L
---
K
I
------
A
K
I
Y
G
G
K
A
I
Y
P
Q
I
K
A
L
-
K
N
--
A
-
N
I
V
V
G
T
P
G
R
I
L
D
H
I
N
R
----
G
-
T
L
--
N
-
L
K
N
-
V
K
Y
F
I
L
D
E
A
D
E
M
L
---
N
M
-
G
-
F
I
K
D
V
E
--
K
I
L
N
--
A
C
----
N
-------
K
-------
D
--
K
-------
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
Y
S
--
F
I
K
--------
A
K
-
I
N
A
--
N
I
E
Q
S
Y
V
E
V
N
E
-
N
-
E
-
R
F
----
E
A
----
L
--------
C
R
L
L
K
-
N
--
K
E
F
Y
G
L
-
V
-
F
C
K
T
K
R
-
D
T
K
E
L
A
S
M
L
R
D
I
---
G
F
K
---
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
------
N
P
------
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
R
-
E
-
Y
-
K
K
L
R
Y
I
E
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
85.20
40%
-108
- C3 -
1HV8
5
H669_METJA
A:
[3-365]
-------------
V
E
Y
M
N
F
N
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
--
N
--
D
E-
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
---
L
V
--
N
--
E
N
--------------------------
N
G
---
I
E
-
A
I
I
----
L
T
P
T
R
E
L
A
I
Q
V
A
D
-----
E
I
E
S
L
K
G
N
-
K
---
N
L
---
K
I
------
A
K
I
Y
G
G
K
A
I
Y
P
Q
I
K
A
--
L
K
-
N
A
-
N
I
V
V
G
T
P
G
R
I
L
D
H
I
N
R
----
G
-
T
L
--
N
-
L
K
N
-
V
K
Y
F
I
L
D
E
A
D
E
M
L
---
N
M
-
G
-
F
I
K
D
V
E
--
K
I
L
N
--
A
C
----
N
-------
K
-------
D
--
K
-------
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
Y
S
--
F
I
K
A
K
---------
I
N
A
--
N
I
E
Q
S
Y
V
E
V
N
E
-
N
-
E
-
R
F
----
E
A
----
L
--------
C
R
L
L
K
----
N
K
E
F
Y
G
-
L
V
F
C
K
T
K
R
-
D
T
K
E
L
A
S
M
L
R
D
I
---
G
F
K
---
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
------
N
P
------
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
R
-
E
-
Y
-
K
K
L
R
Y
I
E
R
A
M
K
L
K
I
K
K
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
84.24
34%
-96
- C3 -
2HYI
3
IF4A3_HUMAN
I:
[40-413]
------------------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
--
D
--
I
Q
------------------
V
-------
R
E
---
T
Q
-
A
L
I
----
L
A
P
T
R
E
L
A
V
Q
I
Q
K
-----
G
L
L
A
L
G
D
Y
M
----
N
V
---
Q
C
------
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
-
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
----
R
-
S
L
--
R
-
T
R
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
K
E
Q
I
Y
--
D
V
Y
R
--
Y
L
----
P
-------
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
--
R
I
L
V
K
R
D
----
E
L
-
T
L
E
--
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
W
K
F
----
D
T
----
L
--------
C
D
L
Y
D
-
T
--
L
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
-
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
---
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
-
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
M
P
M
N
V
A
D
L
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.16
34%
-98
- C3 -
3EX7
4
IF4A3_HUMAN
C:
[40-413]
------------------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
--
D
--
I
Q
------------------
V
-------
R
E
---
T
Q
-
A
L
I
----
L
A
P
T
R
E
L
A
V
Q
I
Q
K
-----
G
L
L
A
L
G
D
Y
M
----
N
V
---
Q
C
------
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
-
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
----
R
-
S
L
--
R
-
T
R
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
K
E
Q
I
Y
--
D
V
Y
R
--
Y
L
----
P
-------
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
--
R
I
L
V
K
R
D
----
E
L
-
T
L
E
--
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
W
K
F
----
D
T
----
L
--------
C
D
L
Y
D
-
T
--
L
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
-
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
---
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
-
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
M
P
M
N
V
A
D
L
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
84.08
34%
-99
- C3 -
3EX7
4
IF4A3_HUMAN
H:
[40-413]
------------------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
--
D
--
I
Q
------------------
V
-------
R
E
---
T
Q
-
A
L
I
----
L
A
P
T
R
E
L
A
V
Q
I
Q
K
-----
G
L
L
A
L
G
D
Y
M
----
N
V
---
Q
C
------
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
-
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
----
R
-
S
L
--
R
-
T
R
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
K
E
Q
I
Y
--
D
V
Y
R
--
Y
L
----
P
-------
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
--
R
I
L
V
K
R
D
----
E
L
-
T
L
E
--
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
W
K
F
----
D
T
----
L
--------
C
D
L
Y
D
-
T
--
L
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
-
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
---
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
-
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
M
P
M
N
V
A
D
L
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
83.94
34%
-97
- C3 -
2XB2
4
IF4A3_HUMAN
A:
[40-411]
------------------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
--
D
--
I
Q
------------------
V
-------
R
E
---
T
Q
-
A
L
I
----
L
A
P
T
R
E
L
A
V
Q
I
Q
K
-----
G
L
L
A
L
G
D
Y
M
----
N
V
---
Q
C
------
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
-
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
----
R
-
S
L
--
R
-
T
R
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
K
E
Q
I
Y
--
D
V
Y
R
--
Y
L
----
P
-------
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
--
R
I
L
V
K
R
D
----
E
L
-
T
L
E
--
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
W
K
F
----
D
T
----
L
--------
C
D
L
Y
D
-
T
--
L
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
-
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
---
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
-
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
M
P
M
N
V
A
D
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.69
34%
-97
- C3 -
2J0Q
3
IF4A3_HUMAN
A:
[39-410]
------------------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
--
D
--
I
Q
------------------
V
-------
R
E
---
T
Q
-
A
L
I
----
L
A
P
T
R
E
L
A
V
Q
I
Q
K
-----
G
L
L
A
L
G
D
Y
M
----
N
V
---
Q
C
------
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
-
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
----
R
-
S
L
--
R
-
T
R
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
K
E
Q
I
Y
--
D
V
Y
R
--
Y
L
----
P
-------
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
--
R
I
L
V
K
R
D
----
E
L
-
T
L
E
--
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
W
K
F
----
D
T
----
L
--------
C
D
L
Y
D
-
T
--
L
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
-
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
---
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
-
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
M
P
M
N
V
A
D
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
83.55
35%
-108
- C3 -
4CT4
2
DDX6_HUMAN
D:
[16-366]
---------------------------
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
--
S
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
---
R
L
--
D
--
L
K
------------------
K
-------
D
N
---
I
Q
-
A
M
V
----
I
V
P
T
R
E
L
A
L
Q
V
S
Q
-----
I
C
I
Q
V
S
K
H
M
G
---
G
A
---
K
V
------
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
-
D
D
-
T
V
-
H
V
V
I
A
T
P
G
R
I
L
D
L
I
K
K
----
G
-
V
A
--
K
-
V
D
H
-
V
Q
M
I
V
L
D
E
A
D
K
L
L
---
S
Q
-
D
-
F
V
Q
I
M
E
--
D
I
I
L
--
T
L
----
P
-------
K
-------
N
--
R
-------
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
--
E
I
N
L
M
E
E
----
L
--
T
L
K
--
G
V
T
Q
Y
Y
A
Y
V
T
E
-
R
-
Q
-
K
V
----
H
C
----
L
--------
N
T
L
F
S
-
R
--
L
Q
I
N
Q
S
-
I
I
F
C
N
S
S
Q
-
R
V
E
L
L
A
K
K
I
S
Q
L
---
G
Y
S
---
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
----
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
-
D
-
R
-
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
83.46
32%
-111
- C3 -
1S2M
-
DHH1_YEAST
A:
[48-409]
------------------
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
--
T
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
---
K
V
--
K
--
P
K
------------------
L
-------
N
K
---
I
Q
-
A
L
I
----
M
V
P
T
R
E
L
A
L
Q
T
S
Q
-----
V
V
R
T
L
G
K
H
C
----
G
I
---
S
C
------
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
-
N
E
-
T
V
-
H
I
L
V
G
T
P
G
R
V
L
D
L
A
S
R
----
K
-
V
A
--
D
-
L
S
D
-
C
S
L
F
I
M
D
E
A
D
K
M
L
---
S
R
-
D
-
F
K
T
I
I
E
--
Q
I
L
S
--
F
L
----
P
-------
P
-------
T
--
H
-------
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
Y
--
E
I
N
L
M
E
E
----
L
--
T
L
K
--
G
I
T
Q
Y
Y
A
F
V
E
E
-
R
-
Q
-
K
L
----
H
C
----
L
--------
N
T
L
F
S
-
K
--
L
Q
I
N
Q
A
-
I
I
F
C
N
S
T
N
-
R
V
E
L
L
A
K
K
I
T
D
L
---
G
Y
S
---
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
-
D
-
R
-
F
N
L
Y
K
I
E
Q
E
L
G
T
E
I
A
A
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
83.34
34%
-97
- C3 -
2J0Q
3
IF4A3_HUMAN
B:
[39-410]
------------------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
--
D
--
I
Q
------------------
V
-------
R
E
---
T
Q
-
A
L
I
----
L
A
P
T
R
E
L
A
V
Q
I
Q
K
-----
G
L
L
A
L
G
D
Y
M
----
N
V
---
Q
C
------
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
-
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
----
R
-
S
L
--
R
-
T
R
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
K
E
Q
I
Y
--
D
V
Y
R
--
Y
L
----
P
-------
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
--
R
I
L
V
K
R
D
----
E
L
-
T
L
E
--
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
W
K
F
----
D
T
----
L
--------
C
D
L
Y
D
-
T
--
L
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
-
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
---
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
-
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
M
P
M
N
V
A
D
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
83.22
34%
-107
- C3 -
2J0U
1
IF4A3_HUMAN
A:
[3-371]
------------------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
V
S
V
L
Q
---
C
L
--
D
--
I
Q
------------------
V
-------
R
E
---
T
Q
-
A
L
I
----
L
A
P
T
R
E
L
A
V
Q
V
Q
K
-----
G
L
L
A
L
G
D
Y
M
----
N
V
---
Q
C
------
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
-
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
----
R
-
S
L
--
R
-
T
R
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
K
E
Q
I
Y
--
D
V
Y
R
--
Y
L
----
P
-------
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
--
R
I
L
V
K
R
D
----
E
L
-
T
L
E
--
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
W
K
F
----
D
T
----
L
--------
C
D
L
Y
D
------
I
T
Q
A
-
V
I
F
C
N
T
K
R
-
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
---
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
--
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
V
N
F
V
K
N
D
-
D
-
I
-
R
V
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
M
P
M
N
V
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
83.18
35%
-111
- C3 -
4CT4
3
DDX6_HUMAN
B:
[16-366]
---------------------------
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
--
S
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
---
R
L
--
D
--
L
K
------------------
K
-------
D
N
---
I
Q
-
A
M
V
----
I
V
P
T
R
E
L
A
L
Q
V
S
Q
-----
I
C
I
Q
V
S
K
H
M
G
---
G
A
---
K
V
------
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
-
D
D
-
T
V
-
H
V
V
I
A
T
P
G
R
I
L
D
L
I
K
K
----
G
-
V
A
--
K
-
V
D
H
-
V
Q
M
I
V
L
D
E
A
D
K
L
L
---
S
Q
-
D
-
F
V
Q
I
M
E
--
D
I
I
L
--
T
L
----
P
-------
K
-------
N
--
R
-------
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
--
E
I
N
L
M
E
E
----
L
--
T
L
K
--
G
V
T
Q
Y
Y
A
Y
V
T
E
-
R
-
Q
-
K
V
----
H
C
----
L
--------
N
T
L
F
S
-
R
--
L
Q
I
N
Q
S
-
I
I
F
C
N
S
S
Q
-
R
V
E
L
L
A
K
K
I
S
Q
L
---
G
Y
S
---
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
-
D
-
R
-
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
83.13
37%
-105
- C3 -
2I4I
1
DDX3X_HUMAN
A:
[26-384]
---------------------------
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
--
Y
--
S
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
-------
Q
Y
---
P
I
-
S
L
V
----
L
A
P
T
R
E
L
A
V
Q
I
Y
E
-----
E
A
R
K
F
S
Y
R
-
S
---
R
V
---
R
P
------
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
-
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
----
G
-
K
I
--
G
-
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
E
P
Q
I
R
--
R
I
V
E
QD
T
M
----
P
-------
P
-------
K
GV
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
--
F
L
A
V
G
---------
T
S
E
--
N
I
T
Q
K
V
V
W
V
E
E
-
S
-
D
-
K
R
----
S
F
----
L
--------
L
D
L
L
N
-
A
--
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
-
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
---
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
-
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
83.00
37%
-95
- C3 -
4PXA
5
DDX3X_HUMAN
A:
[76-434]
---------------------------
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
--
Y
--
S
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
-------
Q
Y
---
P
I
-
S
L
V
----
L
A
P
T
R
E
L
A
V
Q
I
Y
E
-----
E
A
R
K
F
S
Y
R
-
S
---
R
V
---
R
P
------
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
-
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
----
G
-
K
I
--
G
-
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
V
M
-
G
-
F
E
P
Q
I
R
--
R
I
V
E
QD
T
M
----
P
-------
P
-------
K
GV
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
--
F
L
A
V
G
R
V
----
G
S
-
T
S
E
--
N
I
T
Q
K
V
V
W
V
E
E
-
S
-
D
-
K
R
----
S
F
----
L
--------
L
D
L
L
N
-
A
--
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
-
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
---
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
E
R
-
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
82.95
34%
-129
- C3 -
2VSO
1
IF4A_YEAST
A:
[24-386]
------------------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
---
R
I
--
D
--
T
S
------------------
V
-------
K
A
---
P
Q
-
A
L
M
----
L
A
P
T
R
E
L
A
L
Q
I
Q
K
-----
V
V
M
A
L
A
F
H
M
----
D
I
---
K
V
------
H
A
C
I
G
----------
L
-
R
D
--
A
-
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
----
R
-
R
F
--
R
-
T
D
K
-
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
S
-
G
-
F
K
E
Q
I
Y
--
Q
I
F
T
--
L
L
----
P
-------
P
-------
T
--
T
-------
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
--
R
I
L
V
K
K
D
----
E
L
-
T
L
E
--
G
I
K
Q
F
Y
V
N
V
E
E
-
E
-
E
Y
K
Y
----
E
C
----
L
--------
T
D
L
Y
D
-
S
--
I
S
V
T
Q
A
-
V
I
F
C
N
T
R
R
-
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
---
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
-
D
-
V
-
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
82.81
34%
-130
- C3 -
2VSO
1
IF4A_YEAST
B:
[24-386]
------------------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
---
R
I
--
D
--
T
S
------------------
V
-------
K
A
---
P
Q
-
A
L
M
----
L
A
P
T
R
E
L
A
L
Q
I
Q
K
-----
V
V
M
A
L
A
F
H
M
----
D
I
---
K
V
------
H
A
C
I
G
----------
L
-
R
D
--
A
-
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
----
R
-
R
F
--
R
-
T
D
K
-
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
S
-
G
-
F
K
E
Q
I
Y
--
Q
I
F
T
--
L
L
----
P
-------
P
-------
T
--
T
-------
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
--
R
I
L
V
K
K
D
----
E
L
-
T
L
E
--
G
I
K
Q
F
Y
V
N
V
E
E
-
E
-
E
Y
K
Y
----
E
C
----
L
--------
T
D
L
Y
D
-
S
--
I
S
V
T
Q
A
-
V
I
F
C
N
T
R
R
-
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
---
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
-
D
-
V
-
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
82.42
34%
-126
- C3 -
2VSX
1
IF4A_YEAST
A:
[24-386]
------------------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
---
R
I
--
D
--
T
S
------------------
V
-------
K
A
---
P
Q
-
A
L
M
----
L
A
P
T
R
E
L
A
L
Q
I
Q
K
-----
V
V
M
A
L
A
F
H
M
----
D
I
---
K
V
------
H
A
C
I
G
----------
L
-
R
D
--
A
-
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
----
R
-
R
F
--
R
-
T
D
K
-
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
S
-
G
-
F
K
E
Q
I
Y
--
Q
I
F
T
--
L
L
----
P
-------
P
-------
T
--
T
-------
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
--
R
I
L
V
K
K
D
----
E
L
-
T
L
E
--
G
I
K
Q
F
Y
V
N
V
E
E
-
E
-
E
Y
K
Y
----
E
C
----
L
--------
T
D
L
Y
D
-
S
--
I
S
V
T
Q
A
-
V
I
F
C
N
T
R
R
-
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
---
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
-
D
-
V
-
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
82.33
34%
-125
- C3 -
2VSX
1
IF4A_YEAST
B:
[24-386]
------------------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
---
R
I
--
D
--
T
S
------------------
V
-------
K
A
---
P
Q
-
A
L
M
----
L
A
P
T
R
E
L
A
L
Q
I
Q
K
-----
V
V
M
A
L
A
F
H
M
----
D
I
---
K
V
------
H
A
C
I
G
----------
L
-
R
D
--
A
-
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
----
R
-
R
F
--
R
-
T
D
K
-
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
S
-
G
-
F
K
E
Q
I
Y
--
Q
I
F
T
--
L
L
----
P
-------
P
-------
T
--
T
-------
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
--
R
I
L
V
K
K
D
----
E
L
-
T
L
E
--
G
I
K
Q
F
Y
V
N
V
E
E
-
E
-
E
Y
K
Y
----
E
C
----
L
--------
T
D
L
Y
D
-
S
--
I
S
V
T
Q
A
-
V
I
F
C
N
T
R
R
-
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
---
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
-
D
-
V
-
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
82.31
32%
-112
- C3 -
3EWS
1
DD19B_HUMAN
A:
[63-425]
-----------------
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
--
E
--
P
A
------------------
N
-------
K
Y
---
P
Q
-
C
L
C
----
L
S
P
T
Y
E
L
A
L
Q
T
G
K
-----
V
I
E
Q
M
G
K
F
Y
P
---
E
L
---
K
L
------
A
Y
A
V
R
G
N
K
L
E
---
R
G
Q
-
K
I
-
S
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
S
K
LKFI
D
-
P
K
------
K
-
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
T
Q
G
-
H
Q
D
Q
S
I
--
R
I
Q
R
--
M
L
----
P
-------
R
-------
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
--
V
I
K
L
K
R
E
----
E
E
-
T
L
D
--
T
I
K
Q
Y
Y
V
L
C
S
S
R
D
-
E
-
K
F
----
Q
A
----
L
--------
C
N
L
Y
G
-
A
--
I
T
I
A
Q
A
-
M
I
F
C
H
T
R
K
-
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
---
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
----
G
K
R
G
L
A
V
N
M
V
D
S
K
-
H
-
S
---
M
N
I
L
N
R
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
HHSearch
82.10
33%
-97
- C3 -
3FHT
4
DD19B_HUMAN
A:
[21-399]
------------
L
Y
S
V
K
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
--
E
--
P
A
------------------
N
-------
K
Y
---
P
Q
-
C
L
C
----
L
S
P
T
Y
E
L
A
L
Q
T
G
K
-----
V
I
E
Q
M
G
K
F
Y
P
---
E
L
---
K
L
------
A
Y
A
V
R
G
N
K
L
---
E
R
G
Q
-
K
I
-
S
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
S
K
----
L
K
F
I
--
D
-
P
K
K
-
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
T
Q
G
-
H
Q
D
Q
S
I
--
R
I
Q
R
--
M
L
----
P
-------
R
-------
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
--
V
I
K
L
K
R
E
----
E
E
-
T
L
D
--
T
I
K
Q
Y
Y
V
L
C
S
S
R
D
-
E
-
K
F
----
Q
A
----
L
--------
C
N
L
Y
G
-
A
--
I
T
I
A
Q
A
-
M
I
F
C
H
T
R
K
-
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
---
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
DKDGNP
D
N
------
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
-
M
-
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
81.69
32%
-112
- C3 -
4BRW
2
DHH1_YEAST
A:
[3-364]
------------------
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
--
T
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
---
K
V
--
K
--
P
K
------------------
L
-------
N
K
---
I
Q
-
A
L
I
----
M
V
P
T
R
E
L
A
L
Q
T
S
Q
-----
V
V
R
T
L
G
K
H
C
----
G
I
---
S
C
------
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
-
N
E
-
T
V
-
H
I
L
V
G
T
P
G
R
V
L
D
L
A
S
R
----
K
-
V
A
--
D
-
L
S
D
-
C
S
L
F
I
M
D
E
A
D
K
M
L
---
S
R
-
D
-
F
K
T
I
I
E
--
Q
I
L
S
--
F
L
----
P
-------
P
-------
T
--
H
-------
Q
S
L
L
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
Y
--
E
I
N
L
M
E
E
----
L
--
T
L
K
--
G
I
T
Q
Y
Y
A
F
V
E
E
-
R
-
Q
-
K
L
----
H
C
----
L
--------
N
T
L
F
S
-
K
--
L
Q
I
N
Q
A
-
I
I
F
C
N
S
T
N
-
R
V
E
L
L
A
K
K
I
T
D
L
---
G
Y
S
---
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
-
D
-
R
-
F
N
L
Y
K
I
E
Q
E
L
G
T
E
I
A
A
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
81.57
37%
-88
- C3 -
2DB3
3
VASA1_DROME
D:
[46-412]
------
V
T
G
S
D
V
P
Q
P
I
Q
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
K
L
LE
D
--
P
H
------------------
E
-------
L
E
LGR
P
Q
-
V
V
I
----
V
S
P
T
R
E
L
A
I
Q
I
F
N
EARKF
A
F
E
S
Y
L
K
-------
I
---
G
I
------
V
--
Y
G
G
T
S
F
R
H
Q
N
E
C
I
-
T
R
-
G
C
-
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
----
T
-
F
I
--
T
-
F
E
D
-
T
R
F
V
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
S
E
D
M
R
--
R
I
M
T
--
H
V
TMR-
P
-------
E
----------
H
-------
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
--
F
V
A
I
G
I
V
----
G
G
-
A
C
S
--
D
V
K
Q
T
---
I
Y
E
-
V
-
N
-
K
Y
----
A
K
----
R
--------
S
K
L
I
E
-
I
LS
E
Q
A
D
G
T
-
I
V
F
V
E
T
K
R
-
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
---
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
------
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
-
K
-
D
-
R
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
81.37
33%
-106
- C3 -
3RRN
2
DBP5_YEAST
A:
[6-370]
-----------------
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
---
R
V
--
N
--
P
E
------------------
D
-------
A
S
---
P
Q
-
A
I
C
----
L
A
P
S
R
E
L
A
R
Q
T
L
E
-----
V
V
Q
E
M
G
K
F
T
K
---
I
T
---
S
Q
------
L
I
V
P
D
S
F
E
K
N
K
Q
I
-------
N
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
R
----
K
-
L
M
--
Q
-
L
Q
K
-
I
K
I
F
V
L
D
E
A
D
N
M
L
D
--
Q
Q
-
G
-
L
G
D
Q
C
I
--
R
V
K
R
--
F
L
----
P
-------
K
-------
D
--
T
-------
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
--
T
L
E
L
Q
-----------
D
--
A
I
K
Q
L
Y
M
D
C
K
N
-
E
A
D
-
K
F
----
D
V
----
L
--------
T
E
L
Y
G
-
V
--
M
T
I
G
S
S
-
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
-
K
S
E
---
G
H
E
---
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
-
N
-
S
F
N
I
L
S
A
I
Q
K
Y
F
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
81.30
32%
-116
- C3 -
1XTI
4
DX39B_HUMAN
A:
[9-369]
-----------------
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
--
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
---
Q
L
--
E
--
P
V
------------------
T
-------
G
Q
---
V
S
-
V
L
V
----
M
C
H
T
R
E
L
A
F
Q
I
S
K
-----
E
Y
E
R
F
S
K
Y
M
P
---
N
V
---
K
V
------
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
K
K
N
-
C
P
-
H
I
V
V
G
T
P
G
R
I
L
A
L
A
R
N
----
K
-
S
L
--
N
-
L
K
H
-
I
K
H
F
I
L
D
E
C
D
K
M
L
---
E
Q
L
D
-
M
R
R
D
V
Q
--
E
I
F
R
--
M
T
----
P
-------
H
-------
E
--
K
-------
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
--
E
I
F
V
D
D
E
T---
K
L
-
T
L
H
--
G
L
Q
Q
Y
Y
V
K
L
K
D
-
N
-
E
-
K
N
----
R
K
----
L
--------
F
D
L
L
D
-
V
--
L
E
F
N
Q
V
-
V
I
F
V
K
S
V
Q
-
R
C
I
A
L
A
Q
L
L
V
E
Q
---
N
F
P
---
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
E
------
D
S
------
D
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
S
D
E
-
N
D
A
-
K
I
L
N
D
V
Q
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
80.79
37%
-87
- C3 -
2DB3
3
VASA1_DROME
C:
[46-412]
------
V
T
G
S
D
V
P
Q
P
I
Q
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
K
L
LE
D
--
P
H
------------------
E
-------
L
E
LGR
P
Q
-
V
V
I
----
V
S
P
T
R
E
L
A
I
Q
I
F
N
EARKF
A
F
E
S
Y
L
K
-------
I
---
G
I
------
V
--
Y
G
G
T
S
F
R
H
Q
N
E
C
I
-
T
R
-
G
C
-
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
----
T
-
F
I
--
T
-
F
E
D
-
T
R
F
V
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
S
E
D
M
R
--
R
I
M
T
--
H
V
TMR-
P
-------
E
----------
H
-------
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
--
F
V
A
I
G
I
V
----
G
G
-
A
C
S
--
D
V
K
Q
T
---
I
Y
E
-
V
-
N
-
K
Y
----
A
K
----
R
--------
S
K
L
I
E
-
I
LS
E
Q
A
D
G
T
-
I
V
F
V
E
T
K
R
-
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
---
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
------
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
-
K
-
D
-
R
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
80.76
32%
-103
- C3 -
3FHT
4
DD19B_HUMAN
A:
[26-388]
-----------------
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
--
E
--
P
A
------------------
N
-------
K
Y
---
P
Q
-
C
L
C
----
L
S
P
T
Y
E
L
A
L
Q
T
G
K
-----
V
I
E
Q
M
G
K
F
Y
P
---
E
L
---
K
L
------
A
Y
A
V
R
G
N
K
L
E
---
R
G
Q
-
K
I
-
S
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
S
K
LKFI
D
-
P
K
------
K
-
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
T
Q
G
-
H
Q
D
Q
S
I
--
R
I
Q
R
--
M
L
----
P
-------
R
-------
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
--
V
I
K
L
K
R
E
----
E
E
-
T
L
D
--
T
I
K
Q
Y
Y
V
L
C
S
S
R
D
-
E
-
K
F
----
Q
A
----
L
--------
C
N
L
Y
G
-
A
--
I
T
I
A
Q
A
-
M
I
F
C
H
T
R
K
-
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
---
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
-
H
-
S
---
M
N
I
L
N
R
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
80.75
37%
-86
- C3 -
2DB3
3
VASA1_DROME
A:
[46-412]
------
V
T
G
S
D
V
P
Q
P
I
Q
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
K
L
L
E
D
--
P
H
------------------
E
-------
L
E
L
GR
P
Q
-
V
V
I
----
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
S
Y
L
K
-------
I
---
G
I
------
V
--
Y
G
G
T
S
F
R
H
Q
N
E
C
I
-
T
R
-
G
C
-
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
----
T
-
F
I
--
T
-
F
E
D
-
T
R
F
V
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
S
E
D
M
R
--
R
I
M
T
--
H
V
TMR-
P
-------
E
----------
H
-------
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
--
F
V
A
I
G
I
V
----
G
G
-
A
C
S
--
D
V
K
Q
T
---
I
Y
E
-
V
-
N
-
K
Y
----
A
K
----
R
--------
S
K
L
I
E
-
I
L
S
E
Q
A
D
G
T
-
I
V
F
V
E
T
K
R
-
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
---
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
------
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
-
K
-
D
-
R
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
80.55
36%
-90
- C3 -
4D25
4
?
A:
[52-402]
------------------
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
--
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
---
M
L
L
Q
D
--
P
K
------------------
D
L
I
S
E
NG
C
A
Q
---
P
Q
-
V
I
I
----
V
S
P
T
R
E
L
T
L
Q
I
F
N
-----
E
A
R
K
F
S
Y
G
-
S
---
V
L
---
K
V
------
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
-
G
C
-
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
----
N
-
R
V
--
S
-
F
G
S
-
V
R
F
V
V
L
D
Q
A
D
C
M
L
---
D
M
-
G
-
F
M
P
S
I
E
K
M
M
L
H
P
--
T
M
----
V
-------
E
-------
T
TK
R
-------
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
--
F
V
A
V
G
I
V
----
G
G
-
A
S
T
--
D
V
E
Q
I
F
I
E
V
T
K
-
Y
-
E
-
K
R
----
N
S
----
L
--------
K
Q
L
I
E
-
E
--
N
D
G
K
R
I
-
L
V
F
V
E
T
K
R
-
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
---
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
------
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
80.36
33%
-116
- C3 -
1XTI
4
DX39B_HUMAN
A:
[9-355]
-----------------
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
--
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
---
Q
L
--
E
--
P
V
------------------
T
-------
G
Q
---
V
S
-
V
L
V
----
M
C
H
T
R
E
L
A
F
Q
I
S
K
-----
E
Y
E
R
F
S
K
Y
M
P
---
N
V
---
K
V
------
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
-
K
K
-
N
C
P
H
I
V
V
G
T
P
G
R
I
L
A
L
A
R
N
----
K
-
S
L
--
N
-
L
K
H
-
I
K
H
F
I
L
D
E
C
D
K
M
L
E--
Q
L
-
D
-
M
R
R
D
V
Q
--
E
I
F
R
--
M
T
----
P
-------
H
-------
E
--
K
-------
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
--
E
I
F
V
D
D
E
----
T
K
L
T
L
H
--
G
L
Q
Q
Y
Y
V
K
L
K
D
-
N
-
E
-
K
N
----
R
K
----
L
--------
F
D
L
L
D
-
V
--
L
E
F
N
Q
V
-
V
I
F
V
K
S
V
Q
-
R
C
I
A
L
A
Q
L
L
V
E
Q
---
N
F
P
---
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
E
------
D
S
------
D
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
80.26
33%
-105
- C3 -
3RRM
1
DBP5_YEAST
A:
[11-370]
----------------------
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
---
R
V
--
N
--
P
E
------------------
D
-------
A
S
---
P
Q
-
A
I
C
----
L
A
P
S
R
E
L
A
R
Q
T
L
E
-----
V
V
Q
E
M
G
K
F
T
K
---
I
T
---
S
Q
------
L
I
V
P
D
S
F
E
K
N
K
Q
I
-------
N
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
R
----
K
-
L
M
--
Q
-
L
Q
K
-
I
K
I
F
V
L
D
E
A
D
N
M
L
D
--
Q
Q
-
G
-
L
G
D
Q
C
I
--
R
V
K
R
--
F
L
----
P
-------
K
-------
D
--
T
-------
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
--
T
L
E
L
--------
V
-
N
V
D
--
A
I
K
Q
L
Y
M
D
C
K
N
-
E
A
D
-
K
F
----
D
V
----
L
--------
T
E
L
Y
G
-
V
--
M
T
I
G
S
S
-
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
-
K
S
E
---
G
H
E
---
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
------
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
-
N
-
S
F
N
I
L
S
A
I
Q
K
Y
F
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
80.26
36%
-90
- C3 -
4D26
4
?
A:
[52-402]
------------------
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
--
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
---
M
L
L
Q
D
--
P
K
------------------
D
L
I
S
E
NG
C
A
Q
---
P
Q
-
V
I
I
----
V
S
P
T
R
E
L
T
L
Q
I
F
N
-----
E
A
R
K
F
S
Y
G
-
S
---
V
L
---
K
V
------
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
-
G
C
-
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
----
N
-
R
V
--
S
-
F
G
S
-
V
R
F
V
V
L
D
Q
A
D
C
M
L
---
D
M
-
G
-
F
M
P
S
I
E
K
M
M
L
H
P
--
T
M
----
V
-------
E
-------
T
TK
R
-------
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
--
F
V
A
V
G
I
V
----
G
G
-
A
S
T
--
D
V
E
Q
I
F
I
E
V
T
K
-
Y
-
E
-
K
R
----
N
S
----
L
--------
K
Q
L
I
E
-
E
--
N
D
G
K
R
I
-
L
V
F
V
E
T
K
R
-
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
---
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
------
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
80.24
37%
-85
- C3 -
2DB3
3
VASA1_DROME
B:
[46-412]
------
V
T
G
S
D
V
P
Q
P
I
Q
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
K
L
LE
D
--
P
H
------------------
E
-------
L
E
LGR
P
Q
-
V
V
I
----
V
S
P
T
R
E
L
A
I
Q
I
F
N
EARKF
A
F
E
S
Y
L
K
-------
I
---
G
I
------
V
--
Y
G
G
T
S
F
R
H
Q
N
E
C
I
-
T
R
-
G
C
-
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
----
T
-
F
I
--
T
-
F
E
D
-
T
R
F
V
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
S
E
D
M
R
--
R
I
M
T
--
H
V
TMR-
P
-------
E
----------
H
-------
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
--
F
V
A
I
G
I
V
----
G
G
-
A
C
S
--
D
V
K
Q
T
---
I
Y
E
-
V
-
N
-
K
Y
----
A
K
----
R
--------
S
K
L
I
E
-
I
LS
E
Q
A
D
G
T
-
I
V
F
V
E
T
K
R
-
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
---
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
------
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
-
K
-
D
-
R
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
79.98
32%
-102
- C3 -
3G0H
4
DD19B_HUMAN
A:
[42-404]
-----------------
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
--
E
--
P
A
------------------
N
-------
K
Y
---
P
Q
-
C
L
C
----
L
S
P
T
Y
E
L
A
L
Q
T
G
K
-----
V
I
E
Q
M
G
K
F
Y
P
---
E
L
---
K
L
------
A
Y
A
V
R
G
N
K
L
E
---
R
G
Q
-
K
I
-
S
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
S
K
LKFI
D
-
P
K
------
K
-
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
T
Q
G
-
H
Q
D
Q
S
I
--
R
I
Q
R
--
M
L
----
P
-------
R
-------
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
--
V
I
K
L
K
R
E
----
E
E
-
T
L
D
--
T
I
K
Q
Y
Y
V
L
C
S
S
R
D
-
E
-
K
F
----
Q
A
----
L
--------
C
N
L
Y
G
-
A
--
I
T
I
A
Q
A
-
M
I
F
C
H
T
R
K
-
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
---
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
-
H
-
S
---
M
N
I
L
N
R
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
79.79
32%
-102
- C3 -
3FHT
6
DD19B_HUMAN
B:
[26-388]
-----------------
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
--
E
--
P
A
------------------
N
-------
K
Y
---
P
Q
-
C
L
C
----
L
S
P
T
Y
E
L
A
L
Q
T
G
K
-----
V
I
E
Q
M
G
K
F
Y
P
---
E
L
---
K
L
------
A
Y
A
V
R
G
N
----------
K
I
-
S
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
S
K
LKFI
D
-
P
K
------
K
-
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
T
Q
G
-
H
Q
D
Q
S
I
--
R
I
Q
R
--
M
L
----
P
-------
R
-------
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
--
V
I
K
L
K
R
E
----
E
E
-
T
L
D
--
T
I
K
Q
Y
Y
V
L
C
S
S
R
D
-
E
-
K
F
----
Q
A
----
L
--------
C
N
L
Y
G
-
A
--
I
T
I
A
Q
A
-
M
I
F
C
H
T
R
K
-
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
---
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
-
H
-
S
---
M
N
I
L
N
R
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
79.41
33%
-97
- C3 -
3PEW
9
DBP5_YEAST
A:
[6-370]
-----------------
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
---
R
V
--
N
--
P
E
------------------
D
-------
A
S
---
P
Q
-
A
I
C
----
L
A
P
S
R
E
L
A
R
Q
T
L
E
-----
V
V
Q
E
M
G
K
F
T
K
---
I
T
---
S
Q
------
L
I
V
P
D
S
F
E
K
N
K
Q
I
-------
N
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
R
----
K
-
L
M
--
Q
-
L
Q
K
-
I
K
I
F
V
L
D
E
A
D
N
M
L
D
--
Q
Q
-
G
-
L
G
D
Q
C
I
--
R
V
K
R
--
F
L
----
P
-------
K
-------
D
--
T
-------
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
--
T
L
E
L
Q
T
N
----
E
V
-
N
V
D
--
A
I
K
Q
L
Y
M
D
C
K
N
-
E
A
D
-
K
F
----
D
V
----
L
--------
T
E
L
Y
G
-
V
--
M
T
I
G
S
S
-
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
-
K
S
E
---
G
H
E
---
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
-
N
-
S
F
N
I
L
S
A
I
Q
K
Y
F
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
78.32
33%
-100
- C3 -
3PEY
11
DBP5_YEAST
A:
[6-370]
-----------------
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
---
R
V
--
N
--
P
E
------------------
D
-------
A
S
---
P
Q
-
A
I
C
----
L
A
P
S
R
E
L
A
R
Q
T
L
E
-----
V
V
Q
E
M
G
K
F
T
K
---
I
T
---
S
Q
------
L
I
V
P
D
S
F
E
K
N
K
Q
I
-------
N
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
R
----
K
-
L
M
--
Q
-
L
Q
K
-
I
K
I
F
V
L
D
E
A
D
N
M
L
D
--
Q
Q
-
G
-
L
G
D
Q
C
I
--
R
V
K
R
--
F
L
----
P
-------
K
-------
D
--
T
-------
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
--
T
L
E
L
Q
T
N
----
E
V
-
N
V
D
--
A
I
K
Q
L
Y
M
D
C
K
N
-
E
A
D
-
K
F
----
D
V
----
L
--------
T
E
L
Y
G
-
L
--
M
T
I
G
S
S
-
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
-
K
S
E
---
G
H
E
---
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
-
N
-
S
F
N
I
L
S
A
I
Q
K
Y
F
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
78.14
30%
-99
- C3 -
3SQW
3
MS116_YEAST
A:
[27-409]
----------------------
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
--
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
---
H
L
--
I
--
N
T
KFDS--------------
Q
-------
Y
M
---
V
K
-
A
V
I
----
V
A
P
T
R
D
L
A
L
Q
I
E
A
-----
E
V
K
K
I
H
D
M
N
Y
GLK
K
Y
---
A
C
------
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
K
L
-
R
P
-
N
I
V
I
A
T
P
G
R
L
I
D
V
L
E
K
----
Y
S
N
K
--
F
-
F
R
F
-
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
I
-
G
-
F
R
D
D
L
E
--
T
I
S
G
--
I
L
----
N
-------
E
K
NSKSAD
N
--
I
-------
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
--
C
L
F
L
D
T
V
DKNE
P
E
-
A
H
E
--
R
I
D
Q
S
V
V
I
S
E
K
F
A
-
N
-
S
I
----
F
A
A
V
E
H
I
--------
K
K
Q
I
K
E
R
--
D
S
N
Y
K
A
-
I
I
F
A
P
T
V
K
-
F
T
S
F
L
C
S
I
L
K
N
E
FKK
D
L
P
---
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
-
E
-
L
-
P
F
V
R
E
L
E
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
78.11
30%
-98
- C3 -
3I5X
3
MS116_YEAST
A:
[78-460]
----------------------
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
--
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
---
H
L
--
I
--
N
T
KFDS--------------
Q
-------
Y
M
---
V
K
-
A
V
I
----
V
A
P
T
R
D
L
A
L
Q
I
E
A
-----
E
V
K
K
I
H
D
M
N
Y
---
G
L
KKY
A
C
------
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
K
L
-
R
P
-
N
I
V
I
A
T
P
G
R
L
I
D
V
L
E
K
----
Y
S
N
K
--
F
-
F
R
F
-
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
I
-
G
-
F
R
D
D
L
E
--
T
I
S
G
--
I
L
----
N
E
K
NSKSA
D
-------
N
--
I
-------
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
--
C
L
F
L
D
T
V
DKNE
P
E
-
A
H
E
--
R
I
D
Q
S
V
V
I
S
E
K
F
A
-
N
-
S
I
F
A
A
V
E
H
----
I
--------
K
K
Q
I
K
E
R
--
D
S
N
Y
K
A
-
I
I
F
A
P
T
V
K
-
F
T
S
F
L
C
S
I
L
K
N
E
FKK
D
L
P
---
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
-
E
-
L
-
P
F
V
R
E
L
E
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
77.22
33%
-92
- C3 -
3PEY
11
DBP5_YEAST
A:
[4-378]
---------------
A
K
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
---
R
V
--
N
--
P
E
------------------
D
-------
A
S
---
P
Q
-
A
I
C
----
L
A
P
S
R
E
L
A
R
Q
T
L
E
-----
V
V
Q
E
M
G
K
F
-
T
---
K
I
---
T
S
------
Q
L
I
V
P
D
S
F
E
K
----
N
K
-
Q
I
-
N
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
R
----
K
-
L
M
--
Q
-
L
Q
K
-
I
K
I
F
V
L
D
E
A
D
N
M
L
---
D
Q
Q
G
-
L
G
D
Q
C
I
--
R
V
K
R
--
F
L
----
P
-------
K
-------
D
--
T
-------
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
--
T
L
E
L
Q
T
N
----
E
V
-
N
V
D
--
A
I
K
Q
L
Y
M
D
C
K
N
E
A
-
D
-
K
F
----
D
V
----
L
--------
T
E
L
Y
G
-
L
--
M
T
I
G
S
S
-
I
I
F
V
A
T
K
K
-
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
---
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
-
N
-
S
-
F
N
I
L
S
A
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
74.91
31%
-90
- C3 -
3I61
4
MS116_YEAST
A:
[86-450]
------------------------------
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
---
H
L
--
I
--
N
T
------------------
K
-------
F
D
---
S
Q
-
Y
M
V
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
-----
E
V
K
K
I
H
D
M
N
Y
---
G
L
KKY
A
C
------
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
-
N
K
L
R
P
-
N
I
V
I
A
T
P
G
R
L
I
D
V
L
E
K
Y---
S
-
N
K
--
F
-
F
R
F
-
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
I
-
G
-
F
R
D
D
L
E
--
T
I
S
G
--
I
L
----
N
-------
E
-------
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
D
K
----
N
E
-
P
E
A
HE
R
I
D
Q
S
--
V
V
I
S
-
E
-
K
-
F
A
----
N
S
----
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
-
R
--
D
S
N
Y
K
A
-
I
I
F
A
P
T
V
K
-
F
T
S
F
L
C
S
I
L
K
N
E
---
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
-
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
74.71
31%
-91
- C3 -
3I62
4
MS116_YEAST
A:
[86-450]
------------------------------
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
---
H
L
--
I
--
N
T
------------------
K
-------
F
D
---
S
Q
-
Y
M
V
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
-----
E
V
K
K
I
H
D
M
N
Y
---
G
L
KKY
A
C
------
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
-
N
K
L
R
P
-
N
I
V
I
A
T
P
G
R
L
I
D
V
L
E
K
Y---
S
-
N
K
--
F
-
F
R
F
-
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
I
-
G
-
F
R
D
D
L
E
--
T
I
S
G
--
I
L
----
N
-------
E
-------
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
D
K
----
N
E
-
P
E
A
HE
R
I
D
Q
S
--
V
V
I
S
-
E
-
K
-
F
A
----
N
S
----
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
-
R
--
D
S
N
Y
K
A
-
I
I
F
A
P
T
V
K
-
F
T
S
F
L
C
S
I
L
K
N
E
---
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
-
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
74.54
31%
-91
- C3 -
3I5X
3
MS116_YEAST
A:
[86-450]
------------------------------
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
---
H
L
--
I
--
N
T
------------------
K
-------
F
D
---
S
Q
-
Y
M
V
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
-----
E
V
K
K
I
H
D
M
N
Y
---
G
L
KKY
A
C
------
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
-
N
K
L
R
P
-
N
I
V
I
A
T
P
G
R
L
I
D
V
L
E
K
Y---
S
-
N
K
--
F
-
F
R
F
-
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
I
-
G
-
F
R
D
D
L
E
--
T
I
S
G
--
I
L
----
N
-------
E
-------
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
D
K
----
N
E
-
P
E
A
HE
R
I
D
Q
S
--
V
V
I
S
-
E
-
K
-
F
A
----
N
S
----
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
-
R
--
D
S
N
Y
K
A
-
I
I
F
A
P
T
V
K
-
F
T
S
F
L
C
S
I
L
K
N
E
---
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
-
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
73.99
31%
-91
- C3 -
3I5Y
3
MS116_YEAST
A:
[86-450]
------------------------------
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
---
H
L
--
I
--
N
T
------------------
K
-------
F
D
---
S
Q
-
Y
M
V
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
-----
E
V
K
K
I
H
D
M
N
Y
---
G
L
KKY
A
C
------
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
-
N
K
L
R
P
-
N
I
V
I
A
T
P
G
R
L
I
D
V
L
E
K
Y---
S
-
N
K
--
F
-
F
R
F
-
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
I
-
G
-
F
R
D
D
L
E
--
T
I
S
G
--
I
L
----
N
-------
E
-------
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
D
K
----
N
E
-
P
E
A
HE
R
I
D
Q
S
--
V
V
I
S
-
E
-
K
-
F
A
----
N
S
----
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
-
R
--
D
S
N
Y
K
A
-
I
I
F
A
P
T
V
K
-
F
T
S
F
L
C
S
I
L
K
N
E
---
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
-
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
71.28
31%
-88
- C3 -
3SQX
3
MS116_YEAST
A:
[45-399]
----------------------------------------
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
---
H
L
--
I
--
N
T
------------------
K
-------
F
D
---
S
Q
-
Y
M
V
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
-----
E
V
K
K
I
H
D
M
N
Y
---
G
L
KKY
A
C
------
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
-
N
K
L
R
P
-
N
I
V
I
A
T
P
G
R
L
I
D
V
L
E
K
Y---
S
-
N
K
--
F
-
F
R
F
-
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
I
-
G
-
F
R
D
D
L
E
--
T
I
S
G
--
I
L
----
N
-------
E
-------
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
D
K
----
N
E
-
P
E
A
HE
R
I
D
Q
S
--
V
V
I
S
-
E
-
K
-
F
A
----
N
S
----
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
-
R
--
D
S
N
Y
K
A
-
I
I
F
A
P
T
V
K
-
F
T
S
F
L
C
S
I
L
K
N
E
---
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
-
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
69.84
50%
-110
- C3 -
2GXS
4
?
B:
[3-205]
------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
--
A
--
P
S
------------------
Q
ERG----
R
K
---
P
R
-
A
L
V
----
L
T
P
T
R
E
L
A
L
Q
V
A
S
-----
E
L
T
A
V
A
---
P
---
H
L
---
K
V
------
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
-
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
----
G
-
V
L
--
D
-
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
--
A
L
L
S
--
A
T
----
P
-------
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
--
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
69.38
50%
-112
- C3 -
2GXS
3
?
A:
[3-205]
------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
--
A
--
P
S
------------------
Q
ERG----
R
K
---
P
R
-
A
L
V
----
L
T
P
T
R
E
L
A
L
Q
V
A
S
-----
E
L
T
A
V
A
---
P
---
H
L
---
K
V
------
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
-
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
----
G
-
V
L
--
D
-
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
--
A
L
L
S
--
A
T
----
P
-------
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
--
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
69.19
50%
-115
- C3 -
3MWL
2
?
B:
[3-205]
------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
--
A
--
P
S
------------------
Q
ERG----
R
K
---
P
R
-
A
L
V
----
L
T
P
T
R
E
L
A
L
Q
V
A
S
-----
E
L
T
A
V
A
---
P
---
H
L
---
K
V
------
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
-
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
----
G
-
V
L
--
D
-
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
--
A
L
L
S
--
A
T
----
P
-------
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
--
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
68.91
50%
-112
- C3 -
2GXQ
2
?
A:
[3-205]
------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
--
A
--
P
S
------------------
Q
ERG----
R
K
---
P
R
-
A
L
V
----
L
T
P
T
R
E
L
A
L
Q
V
A
S
-----
E
L
T
A
V
A
---
P
---
H
L
---
K
V
------
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
-
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
----
G
-
V
L
--
D
-
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
--
A
L
L
S
--
A
T
----
P
-------
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
--
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
68.69
50%
-113
- C3 -
3NBF
4
?
C:
[3-205]
------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
--
A
--
P
S
------------------
Q
ERG----
R
K
---
P
R
-
A
L
V
----
L
T
P
T
R
E
L
A
L
Q
V
A
S
-----
E
L
T
A
V
A
---
P
---
H
L
---
K
V
------
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
-
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
----
G
-
V
L
--
D
-
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
--
A
L
L
S
--
A
T
----
P
-------
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
--
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
68.47
50%
-108
- C3 -
3NBF
2
?
A:
[3-205]
------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
--
A
--
P
S
------------------
Q
ERG----
R
K
---
P
R
-
A
L
V
----
L
T
P
T
R
E
L
A
L
Q
V
A
S
-----
E
L
T
A
V
A
---
P
---
H
L
---
K
V
------
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
-
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
----
G
-
V
L
--
D
-
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
--
A
L
L
S
--
A
T
----
P
-------
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
--
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
68.25
50%
-116
- C3 -
3NBF
2
?
D:
[3-205]
------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
----
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
--
A
--
P
S
------------------
Q
ERG----
R
K
---
P
R
-
A
L
V
----
L
T
P
T
R
E
L
A
L
Q
V
A
S
-----
E
L
T
A
V
A
---
P
---
H
L
---
K
V
------
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
-
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
----
G
-
V
L
--
D
-
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
--
A
L
L
S
--
A
T
----
P
-------
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
--
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
68.09
37%
-120
- C3 -
3BER
4
DDX47_HUMAN
A:
[40-249]
-------------
E
E
T
K
T
F
K
D
L
G
V
T
D
V
L
C
E
A
C
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
P
L
A
L
--
Q
--
G
--
R
D
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
I
L
N
---
A
L
--
L
--
E
T
------------------
P
-------
Q
R
---
L
F
-
A
L
V
----
L
T
P
T
R
E
L
A
F
Q
I
S
E
-----
Q
F
E
A
L
G
S
S
I
----
G
V
---
Q
S
------
A
V
I
V
G
G
I
D
S
M
S
Q
S
L
A
L
-
A
K
-
K
P
-
H
I
I
I
A
T
P
G
R
L
I
D
H
L
E
N
----
T
-
K
G
--
F
N
L
R
A
-
L
K
Y
L
V
M
D
E
A
D
R
I
L
---
N
M
-
D
-
F
E
T
E
V
D
--
K
I
L
K
--
V
I
----
P
-------
R
-------
D
--
R
-------
K
T
F
L
F
S
A
T
M
T
K
K
V
Q
K
L
Q
R
A
A
L
K
N
P
V
--
K
C
A
V
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
67.13
50%
-112
- C3 -
3MWK
2
?
B:
[3-205]
------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
--
A
--
P
S
------------------
Q
ERG----
R
K
---
P
R
-
A
L
V
----
L
T
P
T
R
E
L
A
L
Q
V
A
S
-----
E
L
T
A
V
A
---
P
---
H
L
---
K
V
------
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
-
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
----
G
-
V
L
--
D
-
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
--
A
L
L
S
--
A
T
----
P
-------
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
--
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
66.76
50%
-104
- C3 -
3NBF
2
?
B:
[3-205]
------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
--
A
--
P
S
------------------
Q
ERG----
R
K
---
P
R
-
A
L
V
----
L
T
P
T
R
E
L
A
L
Q
V
A
S
-----
E
L
T
A
V
A
---
P
---
H
L
---
K
V
------
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
-
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
----
G
-
V
L
--
D
-
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
--
A
L
L
S
--
A
T
----
P
-------
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
--
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
64.89
40%
-110
- C3 -
3FE2
4
DDX5_HUMAN
B:
[19-239]
------
V
R
G
H
N
C
P
K
P
V
L
N
F
Y
E
A
N
F
P
A
N
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
--
S
--
G
--
L
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
---
H
I
--
N
HQ
P
F
------------------
L
-------
E
R
GDG
P
I
-
C
L
V
----
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
-----
V
A
A
E
Y
C
R
A
C
----
R
L
---
K
S
------
T
C
I
Y
G
G
A
P
K
G
P
Q
I
R
D
L
-
E
R
-
G
V
-
E
I
C
I
A
T
P
G
R
L
I
D
F
L
E
C
----
G
-
K
T
--
N
-
L
R
R
-
T
T
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
E
P
Q
I
R
--
K
I
V
D
--
Q
I
----
R
-------
P
-------
D
--
R
-------
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
Y
I
--
H
I
N
I
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
64.42
40%
-108
- C3 -
3FE2
3
DDX5_HUMAN
A:
[19-239]
------
V
R
G
H
N
C
P
K
P
V
L
N
F
Y
E
A
N
F
P
A
N
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
--
S
--
G
--
L
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
---
H
I
--
N
H
Q
P
F
------------------
L
-------
E
R
GDG
P
I
-
C
L
V
----
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
-----
V
A
A
E
Y
C
R
A
C
----
R
L
---
K
S
------
T
C
I
Y
G
G
A
P
K
G
P
Q
I
R
D
L
-
E
R
-
G
V
-
E
I
C
I
A
T
P
G
R
L
I
D
F
L
E
C
----
G
-
K
T
--
N
-
L
R
R
-
T
T
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
E
P
Q
I
R
--
K
I
V
D
--
Q
I
----
R
-------
P
-------
D
--
R
-------
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
Y
I
--
H
I
N
I
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
63.39
39%
-108
- C3 -
4PX9
1
DDX3X_HUMAN
A:
[76-284]
---------------------------
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
--
Y
--
S
D
GPGEALRAMKENGRYG
R
R
K
-------
Q
Y
---
P
I
-
S
L
V
----
L
A
P
T
R
E
L
A
V
Q
I
Y
E
-----
E
A
R
K
F
S
Y
R
-
S
---
R
V
---
R
P
------
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
-
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
----
G
-
K
I
--
G
-
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
E
P
Q
I
R
--
R
I
V
E
QD
T
M
----
P
-------
P
-------
K
GV
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
63.29
39%
-107
- C3 -
4PX9
1
DDX3X_HUMAN
C:
[76-284]
---------------------------
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
--
Y
--
S
D
GPGEALRAMKENGRYGRR
K
-------
Q
Y
---
P
I
-
S
L
V
----
L
A
P
T
R
E
L
A
V
Q
I
Y
E
-----
E
A
R
K
F
S
Y
R
-
S
---
R
V
---
R
P
------
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
-
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
----
G
-
K
I
--
G
-
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
E
P
Q
I
R
--
R
I
V
E
QD
T
M
----
P
-------
P
-------
K
GV
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
62.64
39%
-107
- C3 -
4PX9
1
DDX3X_HUMAN
B:
[76-284]
---------------------------
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
--
Y
--
S
D
GPGEALRAMKENGRYG
R
R
K
-------
Q
Y
---
P
I
-
S
L
V
----
L
A
P
T
R
E
L
A
V
Q
I
Y
E
-----
E
A
R
K
F
S
Y
R
-
S
---
R
V
---
R
P
------
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
-
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
----
G
-
K
I
--
G
-
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
E
P
Q
I
R
--
R
I
V
E
QD
T
M
----
P
-------
P
-------
K
GV
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
62.60
40%
-109
- C3 -
1VEC
1
DDX6_HUMAN
B:
[14-206]
---------------------------
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
--
S
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
---
R
L
--
D
--
L
K
------------------
K
-------
D
N
---
I
Q
-
A
M
V
----
I
V
P
T
R
E
L
A
L
Q
V
S
Q
-----
I
C
I
Q
V
S
K
H
M
G
---
G
A
---
K
V
------
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
-
D
D
-
T
V
-
H
V
V
I
A
T
P
G
R
I
L
D
L
I
K
K
----
G
-
V
A
--
K
-
V
D
H
-
V
Q
M
I
V
L
D
E
A
D
K
L
L
---
S
Q
-
D
-
F
V
Q
I
M
E
--
D
I
I
L
--
T
L
----
P
-------
K
-------
N
--
R
-------
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
E
K
P
Y
--
E
I
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
61.92
41%
-114
- C3 -
3IUY
2
DDX53_HUMAN
B:
[28-228]
------------------------
Y
P
D
L
L
K
S
I
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
--
Q
--
G
--
I
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
---
H
L
--
D
S-------------------------------NG-
P
G
-
M
L
V
----
L
T
P
T
R
E
L
A
L
H
V
E
A
-----
E
C
S
K
Y
S
Y
K
-----
G
L
---
K
S
------
I
C
I
Y
G
----------------
V
-
D
I
I
I
A
T
P
G
R
L
N
D
L
Q
M
N
----
N
-
S
V
--
N
-
L
R
S
-
I
T
Y
L
V
I
D
E
A
D
K
M
L
---
D
M
-
E
-
F
E
P
Q
I
R
--
K
I
L
L
--
D
V
----
R
-------
P
-------
D
--
R
-------
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
D
P
M
--
I
V
Y
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
61.48
34%
-108
- C3 -
3FMO
1
DD19B_HUMAN
B:
[93-297]
-----------------
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
--
E
--
P
A
------------------
N
-------
K
Y
---
P
Q
-
C
L
C
----
L
S
P
T
Y
E
L
A
L
Q
T
G
K
-----
V
I
E
Q
M
G
K
F
Y
P
---
E
L
---
K
L
------
A
Y
A
V
R
G
N
K
L
E
---
R
G
Q
-
K
I
-
S
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
S
K
LKFI
D
-
P
K
------
K
-
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
T
Q
G
-
H
Q
D
Q
S
I
--
R
I
Q
R
--
M
L
----
P
-------
R
-------
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
--
V
I
K
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
60.98
41%
-111
- C3 -
3IUY
2
DDX53_HUMAN
A:
[28-228]
------------------------
Y
P
D
L
L
K
S
I
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
--
Q
--
G
--
I
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
---
H
L
--
D
--------------------------------NG-
P
G
-
M
L
V
----
L
T
P
T
R
E
L
A
L
H
V
E
A
-----
E
C
S
K
Y
S
Y
K
-----
G
L
---
K
S
------
I
C
I
Y
G
------
Q
I
E
D
I
-
S
K
-
G
V
-
D
I
I
I
A
T
P
G
R
L
N
D
L
Q
M
N
----
N
-
S
V
--
N
-
L
R
S
-
I
T
Y
L
V
I
D
E
A
D
K
M
L
---
D
M
-
E
-
F
E
P
Q
I
R
--
K
I
L
L
--
D
V
----
R
-------
P
-------
D
--
R
-------
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
D
P
M
--
I
V
Y
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
60.82
33%
-108
- C3 -
1T6N
1
DX39B_HUMAN
B:
[14-220]
----------------
S
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
--
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
---
Q
L
--
E
--
P
V
------------------
T
-------
G
Q
---
V
S
-
V
L
V
----
M
C
H
T
R
E
L
A
F
Q
I
S
K
-----
E
Y
E
R
F
S
K
Y
M
P
---
N
V
---
K
V
------
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
-
K
K
-
N
C
P
H
I
V
V
G
T
P
G
R
I
L
A
L
A
R
N
----
K
-
S
L
--
N
-
L
K
H
-
I
K
H
F
I
L
D
E
C
D
K
M
L
E--
Q
L
-
D
-
M
R
R
D
V
Q
--
E
I
F
R
--
M
T
----
P
-------
H
-------
E
--
K
-------
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
--
E
I
F
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
60.37
33%
-107
- C3 -
1T6N
1
DX39B_HUMAN
A:
[14-220]
----------------
S
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
--
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
---
Q
L
--
E
--
P
V
------------------
T
-------
G
Q
---
V
S
-
V
L
V
----
M
C
H
T
R
E
L
A
F
Q
I
S
K
-----
E
Y
E
R
F
S
K
Y
M
P
---
N
V
---
K
V
------
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
-
K
K
-
N
C
P
H
I
V
V
G
T
P
G
R
I
L
A
L
A
R
N
----
K
-
S
L
--
N
-
L
K
H
-
I
K
H
F
I
L
D
E
C
D
K
M
L
E
--
Q
L
-
D
-
M
R
R
D
V
Q
--
E
I
F
R
--
M
T
----
P
-------
H
-------
E
--
K
-------
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
--
E
I
F
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
60.04
35%
-108
- C3 -
2PL3
6
DDX10_HUMAN
A:
[18-234]
---------
K
I
N
V
N
E
I
T
R
F
S
D
F
P
L
S
K
K
T
L
K
G
L
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
L
A
L
--
Q
--
G
--
K
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
E
A
L
Y
R
L
--
Q
--
W
T
------------------
S
-------
T
D
---
G
L
G
V
L
I
----
I
S
P
T
R
E
L
A
Y
Q
T
F
E
-----
V
L
R
K
V
G
K
N
-
H
---
D
F
---
S
A
------
G
L
I
I
G
G
--
L
K
H
E
A
E
R
I
--
N
-
N
I
-
N
I
L
V
C
T
P
G
R
L
L
Q
H
M
D
E
----
T
-
V
S
--
F
-
H
A
T
D
L
Q
M
L
V
L
D
E
A
D
R
I
L
---
D
M
-
G
-
F
A
D
T
M
N
--
A
V
I
E
--
N
L
----
P
-------
K
-------
K
--
R
-------
Q
T
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
N
P
E
--
Y
V
W
V
H
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
59.85
31%
-105
- C3 -
3B7G
1
DDX20_HUMAN
B:
[24-228]
----------------
A
D
F
E
S
L
L
L
S
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
--
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
---
S
L
--
V
--
L
E
------------------
N
-------
L
S
---
T
Q
-
I
L
I
----
L
A
P
T
R
E
I
A
V
Q
I
H
S
-----
V
I
T
A
I
G
I
K
M
E
---
G
L
---
E
C
------
H
V
F
I
G
G
T
P
L
S
-
Q
D
K
T
R
-
L
K
-
K
C
-
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
E
L
----
D
-
Y
L
--
N
-
P
G
S
-
I
R
L
F
I
L
D
E
A
D
K
L
L
---
E
E
-
G
S
F
Q
E
Q
I
N
--
W
I
Y
S
--
S
L
----
P
-------
A
-------
S
--
K
-------
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
--
F
V
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
59.78
31%
-104
- C3 -
2OXC
1
DDX20_HUMAN
A:
[24-228]
----------------
A
D
F
E
S
L
L
L
S
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
--
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
---
S
L
--
V
--
L
E
------------------
N
-------
L
S
---
T
Q
-
I
L
I
----
L
A
P
T
R
E
I
A
V
Q
I
H
S
-----
V
I
T
A
I
G
I
K
M
E
---
G
L
---
E
C
------
H
V
F
I
G
G
T
P
L
S
-
Q
D
K
T
R
-
L
K
-
K
C
-
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
E
L
----
D
-
Y
L
--
N
-
P
G
S
-
I
R
L
F
I
L
D
E
A
D
K
L
L
---
E
E
-
G
S
F
Q
E
Q
I
N
--
W
I
Y
S
--
S
L
----
P
-------
A
-------
S
--
K
-------
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
--
F
V
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
59.26
31%
-106
- C3 -
3B7G
1
DDX20_HUMAN
A:
[24-228]
----------------
A
D
F
E
S
L
L
L
S
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
--
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
---
S
L
--
V
--
L
E
------------------
N
-------
L
S
---
T
Q
-
I
L
I
----
L
A
P
T
R
E
I
A
V
Q
I
H
S
-----
V
I
T
A
I
G
I
K
M
E
---
G
L
---
E
C
------
H
V
F
I
G
G
T
P
L
S
-
Q
D
K
T
R
-
L
K
-
K
C
-
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
E
L
----
D
-
Y
L
--
N
-
P
G
S
-
I
R
L
F
I
L
D
E
A
D
K
L
L
---
E
E
-
G
S
F
Q
E
Q
I
N
--
W
I
Y
S
--
S
L
----
P
-------
A
-------
S
--
K
-------
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
--
F
V
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
59.12
31%
-107
- C3 -
2OXC
1
DDX20_HUMAN
B:
[24-228]
----------------
A
D
F
E
S
L
L
L
S
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
--
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
---
S
L
--
V
--
L
E
------------------
N
-------
L
S
---
T
Q
-
I
L
I
----
L
A
P
T
R
E
I
A
V
Q
I
H
S
-----
V
I
T
A
I
G
I
K
M
E
---
G
L
---
E
C
------
H
V
F
I
G
G
T
P
L
S
-
Q
D
K
T
R
-
L
K
-
K
C
-
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
E
L
----
D
-
Y
L
--
N
-
P
G
S
-
I
R
L
F
I
L
D
E
A
D
K
L
L
---
E
E
-
G
S
F
Q
E
Q
I
N
--
W
I
Y
S
--
S
L
----
P
-------
A
-------
S
--
K
-------
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
--
F
V
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
56.72
33%
-106
- C3 -
3DKP
4
DDX52_HUMAN
A:
[36-242]
-----------------------
I
N
S
R
L
L
Q
N
I
L
D
A
G
F
Q
M
P
T
P
I
Q
M
Q
A
I
P
V
M
L
--
H
--
G
--
R
E
L
L
A
S
A
P
T
G
S
G
K
T
L
A
F
S
I
P
I
L
M
---
Q
L
K-
Q
--
P
A
------------------
N
-------
K
G
---
F
R
-
A
L
I
----
I
S
P
T
R
E
L
A
S
Q
I
H
R
-----
E
L
I
K
I
S
E
------
G
T
---
G
F
R
I
H
M
I
H
K
A
A
V
A
A
K
K
F
G
P
K
S
S
----
K
-
K
F
-
D
I
L
V
T
T
P
N
R
L
I
Y
L
L
K
Q
----
D
-
P
P
GI
D
-
L
A
S
-
V
E
W
L
V
V
D
E
S
D
K
L
F
E
D
G---
G
-
F
R
D
Q
L
A
--
S
I
F
L
--
A
C
----
T
-------
S
-------
H
--
K
V
------
R
R
A
M
F
S
A
T
F
A
Y
D
V
E
Q
W
C
K
L
N
L
D
N
V
I
--
S
V
S
I
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
19.02
37%
-5
- C3 -
4DB2
3
MS116_YEAST
B:
[66-144]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
-
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
14.80
37%
-3
- C3 -
4DB2
4
MS116_YEAST
C:
[66-144]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
-
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------