@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2857: (2016-02-11 )
MSASILNAQNLSKVVGSAEGKLTILHDLSLDLARGDSLAIVGSSGSGKSTLLGLLAGLDQPSGGEVRLAGHALGDLDEDQRARVRAAHVGFVFQSFQLLDSLDALENVMLPLELEGRADARQRARELLERVGLGQRLGHYPRQLSGGEQQRVAIARAFAAEPDVLFADEPTGNLDSATGERISDLLFELNRERGTTLVLVTHDERLAHRCRRLIRLESGRLIDRVEP
Atome Classification :
(40 SA)
.........10........20........30........40........50........60..----......70........80......----------..90...--...--..100.......-110---..-...--.-----.--.-----.120.-......130-....-.--.-..140.......150.......160.......170.......180.......190.......200.-....-..-210-........220.....------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSASIL
N
A
Q
N
L
S
K
V
V
GSAEG
K
L
T
I
L
H
DLSLDLARGD
S
L
A
I
V
GSSGS
G
K
S
T
L
L
G
L
L
A
GLDQPSG----G
E
V
R
L
AGHALGDL
D
E
D
Q
R
A
R
V
R
A
A
----------
H
V
G
F
V
F
Q
--
S
F
Q
--
L
L
D
S
L
D
A
L
E
NVM-L-----
P
L
-
E
LE--G-----R--
A
-----
D
A
R
Q
R
-
A
R
E
L
L
E
RV--G
L
G
Q
-
R
--L-GHY
P
R
QLSGG
E
Q
Q
R
V
A
I
A
R
A
FAAEP
D
V
L
F
ADEPTGNLDS
A
T
G
E
R
I
S
D
L
L
F
E
L
NRERG
T
T
L
V
L
V
TH
D
-
E
R
L
A
-
H
R
-
C
-
R
-
R
L
I
RLESGRLIDRVEP------------------------------------------------------------------------------------------------------------------
116
HHSearch
92.53
45%
-105
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[2-222]
--
A
E
I
L
R
A
E
N
I
K
K
V
I
R
----
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
----
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
N
R
----------
K
L
G
F
V
F
Q
--
F
H
Y
--
L
I
P
E
L
T
A
L
E
N
V
I
-
V
-----
P
M
-
L
K
M
--
G
-----
K
P
K
K
-----
E
A
K
E
R
-
G
E
Y
L
L
S
E
L
--
G
L
G
D
-
K
--
L
-
S
R
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
G
T
S
I
V
M
V
T
H
E
-
R
E
L
A
-
E
L
-
T
-
H
-
R
T
L
E
M
K
D
G
K
V
V
G
E
I
T
-------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
91.65
44%
-103
- C1 -
2PCJ
1
LOLD_AQUAE
B:
[2-221]
--
A
E
I
L
R
A
E
N
I
K
K
V
I
R
G
Y
E
----
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
----
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
N
R
----------
K
L
G
F
V
F
Q
--
F
H
Y
--
L
I
P
E
L
T
A
L
E
N
V
I
-
V
-----
P
M
-
L
K
M
--
G
-----
K
--
P
KK---
E
A
K
E
R
-
G
E
Y
L
L
S
E
L
--
G
L
G
D
-
K
--
L
-
S
R
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
G
T
S
I
V
M
V
T
H
E
-
R
E
L
A
-
E
L
-
T
-
H
-
R
T
L
E
M
K
D
G
K
V
V
G
E
I
--------------------------------------------------------------------------------------------------------------------
122
Fugue
91.23
38%
-106
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
---
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
----
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-----------
I
G
M
I
F
Q
--
H
F
N
--
L
L
S
S
R
T
V
F
G
N
V
A
-
L
-----
P
L
-
E
L
D
--
N
TP---
K
--
D
-----
E
V
K
R
R
-
V
T
E
L
L
S
L
V
--
G
L
G
D
-
K
--
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
-
M
D
V
V
-
K
R
I
C
-
D
-
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
SEVFSHPKTPLAQKFIQSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV
2
PsiBlast_PDB
91.19
44%
-100
- C1 -
2PCL
12
LOLD_AQUAE
A:
[2-221]
--
A
E
I
L
R
A
E
N
I
K
K
V
I
R
G
Y
E
----
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
----
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
N
R
----------
K
L
G
F
V
F
Q
--
F
H
Y
--
L
I
P
E
L
T
A
L
E
N
V
I
-
V
-----
P
M
-
L
K
M
--
G
-----
K
--
P
K
K
---
E
A
K
E
R
-
G
E
Y
L
L
S
E
L
--
G
L
G
D
-
K
--
L
-
S
R
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
G
T
S
I
V
M
V
T
H
E
-
R
E
L
A
-
E
L
-
T
-
H
-
R
T
L
E
M
K
D
G
K
V
V
G
E
I
--------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.72
44%
-103
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[2-221]
--
A
E
I
L
R
A
E
N
I
K
K
V
I
R
G
Y
E
----
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
----
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
N
R
----------
K
L
G
F
V
F
Q
--
F
H
Y
--
L
I
P
E
L
T
A
L
E
N
V
I
-
V
-----
P
M
-
L
K
M
--
G
-----
K
--
P
K
K
---
E
A
K
E
R
-
G
E
Y
L
L
S
E
L
--
G
L
G
D
-
K
--
L
-
S
R
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
G
T
S
I
V
M
V
T
H
E
-
R
E
L
A
-
E
L
-
T
-
H
-
R
T
L
E
M
K
D
G
K
V
V
G
E
I
--------------------------------------------------------------------------------------------------------------------
118
HHSearch
90.31
43%
-98
- C1 -
3TIF
7
Y796_METJA
A:
[1-229]
----
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
----
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
----------
K
I
G
F
V
F
Q
--
Q
F
N
--
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-----
P
L
-
I
F
K
--
Y
R
G
A
M
S
G
--
E
-----
E
R
R
K
R
-
A
L
E
C
L
K
M
A
--
E
L
E
E
R
F
--
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
-
R
F
-
G
-
E
-
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
89.83
43%
-101
- C1 -
3TIF
7
Y796_METJA
A:
[1-223]
----
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
----
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
----------
K
I
G
F
V
F
Q
--
Q
F
N
--
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-----
P
L
-
I
F
K
--
Y
-----
R
--
G
A
M
S
G
E
E
R
R
K
R
-
A
L
E
C
L
K
M
A
--
E
L
E
E
-
R
--
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
-
R
F
-
G
-
E
-
R
I
I
Y
L
K
D
G
E
V
------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
89.64
43%
-107
- C1 -
3TIF
7
Y796_METJA
B:
[1-223]
----
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
----
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
----------
K
I
G
F
V
F
Q
--
Q
F
N
--
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-----
P
L
-
I
F
K
--
Y
-----
R
--
G
AMSGE
E
R
R
K
R
-
A
L
E
C
L
K
M
A
--
E
L
E
E
-
R
--
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
-
R
F
-
G
-
E
-
R
I
I
Y
L
K
D
G
E
V
------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
89.51
43%
-106
- C1 -
1L2T
4
Y796_METJA
B:
[1-223]
----
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
----
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
----------
K
I
G
F
V
F
Q
--
Q
F
N
--
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-----
P
L
-
I
F
K
--
Y
-----
R
--
G
AMSGE
E
R
R
K
R
-
A
L
E
C
L
K
M
A
--
E
L
E
E
-
R
--
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
-
R
F
-
G
-
E
-
R
I
I
Y
L
K
D
G
E
V
------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.61
43%
-102
- C1 -
1L2T
4
Y796_METJA
A:
[1-223]
----
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
----
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
----------
K
I
G
F
V
F
Q
--
Q
F
N
--
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-----
P
L
-
I
F
K
--
Y
-----
R
--
G
A
M
S
G
E
E
R
R
K
R
-
A
L
E
C
L
K
M
A
--
E
L
E
E
-
R
--
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
-
R
F
-
G
-
E
-
R
I
I
Y
L
K
D
G
E
V
------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.56
45%
-102
- C1 -
1F3O
2
Y796_METJA
A:
[5-223]
--------
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
----
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
----------
K
I
G
F
V
F
Q
--
Q
F
N
--
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-----
P
L
-
I
F
K
--
Y
-----
R
--
G
AMS
G
E
E
R
R
K
R
-
A
L
E
C
L
K
M
A
--
E
L
E
E
-
R
--
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
-
R
F
-
G
-
E
-
R
I
I
Y
L
K
D
G
E
V
------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
87.64
38%
-110
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-245]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
----
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-----------
Q
I
G
M
I
F
Q
--
H
F
N
--
L
L
S
S
R
T
V
F
G
N
V
A
-
L
-----
P
L
-
E
L
D
--
N
TP---
K
--
D
-----
E
V
K
R
R
-
V
T
E
L
L
S
L
V
--
G
L
G
D
-
K
--
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
-
M
D
V
V
-
K
R
I
C
-
D
-
C
V
A
V
I
S
N
G
E
L
I
E
Q
---------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
86.95
38%
-112
- C1 -
3TUI
1
METN_ECOLI
H:
[24-245]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
----
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-----------
Q
I
G
M
I
F
Q
--
H
F
N
--
L
L
S
S
R
T
V
F
G
N
V
A
-
L
-----
P
L
-
E
L
D
--
N
TP---
K
--
D
-----
E
V
K
R
R
-
V
T
E
L
L
S
L
V
--
G
L
G
D
-
K
--
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
-
M
D
V
V
-
K
R
I
C
-
D
-
C
V
A
V
I
S
N
G
E
L
I
E
Q
---------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
86.24
38%
-110
- C1 -
3TUZ
1
METN_ECOLI
H:
[24-245]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
----
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-----------
Q
I
G
M
I
F
Q
--
H
F
N
--
L
L
S
S
R
T
V
F
G
N
V
A
-
L
-----
P
L
-
E
L
D
--
N
TP---
K
--
D
-----
E
V
K
R
R
-
V
T
E
L
L
S
L
V
--
G
L
G
D
-
K
--
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
-
M
D
V
V
-
K
R
I
C
-
D
-
C
V
A
V
I
S
N
G
E
L
I
E
Q
---------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
85.47
39%
-108
- C1 -
4U02
1
?
C:
[3-222]
---
P
I
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
----
G
E
V
V
V
D
G
L
S
V
K
D
---
D
R
A
L
R
E
I
R
R
----------
E
V
G
M
V
F
Q
--
Q
F
N
--
L
F
P
H
M
T
V
L
E
N
V
T
-
L
A----
P
M
-
R
V
R
RW
P
-----
R
--
E
-----
K
A
E
K
K
-
A
L
E
L
L
E
R
V
--
G
I
L
D
-
Q
--
A
-
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
-
R
E
-
V
-
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
85.41
38%
-110
- C1 -
3TUI
1
METN_ECOLI
G:
[24-245]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
----
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-----------
Q
I
G
M
I
F
Q
--
H
F
N
--
L
L
S
S
R
T
V
F
G
N
V
A
-
L
-----
P
L
-
E
L
D
--
N
TP---
K
--
D
-----
E
V
K
R
R
-
V
T
E
L
L
S
L
V
--
G
L
G
D
-
K
--
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
-
M
D
V
V
-
K
R
I
C
-
D
-
C
V
A
V
I
S
N
G
E
L
I
E
Q
---------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
84.99
38%
-106
- C1 -
3TUI
1
METN_ECOLI
C:
[24-245]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
----
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-----------
Q
I
G
M
I
F
Q
--
H
F
N
--
L
L
S
S
R
T
V
F
G
N
V
A
-
L
-----
P
L
-
E
L
D
--
N
TP---
K
--
D
-----
E
V
K
R
R
-
V
T
E
L
L
S
L
V
--
G
L
G
D
-
K
--
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
-
M
D
V
V
-
K
R
I
C
-
D
-
C
V
A
V
I
S
N
G
E
L
I
E
Q
---------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
84.97
38%
-101
- C1 -
1B0U
4
HISP_SALTY
A:
[5-237]
---
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
H
E
----
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
----
G
A
I
I
V
N
G
Q
N
I
-
N
L
V
R
D
K
D
G
Q
L
K
V
A
D
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
--
H
F
N
--
L
W
S
H
M
T
V
L
E
N
V
M
E
A
-----
P
I
-
Q
V
L
--
G
LS---
K
--
H
-----
D
A
R
E
R
-
A
L
K
Y
L
A
K
V
--
G
I
D
E
-
R
--
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
-
E
E
G
K
T
M
V
V
V
T
H
E
-
M
G
F
A
R
H
V
-
S
-
S
-
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
84.57
38%
-107
- C1 -
3TUZ
1
METN_ECOLI
G:
[24-245]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
----
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-----------
Q
I
G
M
I
F
Q
--
H
F
N
--
L
L
S
S
R
T
V
F
G
N
V
A
-
L
-----
P
L
-
E
L
D
--
N
TP---
K
--
D
-----
E
V
K
R
R
-
V
T
E
L
L
S
L
V
--
G
L
G
D
-
K
--
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
-
M
D
V
V
-
K
R
I
C
-
D
-
C
V
A
V
I
S
N
G
E
L
I
E
Q
---------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
84.27
39%
-97
- C1 -
4U02
1
?
A:
[3-222]
---
P
I
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
----
G
E
V
V
V
D
G
L
S
V
K
D
---
D
R
A
L
R
E
I
R
R
----------
E
V
G
M
V
F
Q
--
Q
F
N
--
L
F
P
H
M
T
V
L
E
N
V
T
-
L
A----
P
M
-
R
V
R
RW
P
-----
R
--
E
-----
K
A
E
K
K
-
A
L
E
L
L
E
R
V
--
G
I
L
D
-
Q
--
A
-
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
-
R
E
-
V
-
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
81.44
35%
-105
- C1 -
2OLJ
4
?
A:
[24-243]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
----
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
-
K
V
R
E
-----------
E
V
G
M
V
F
Q
--
R
F
N
--
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A----
P
M
-
K
V
R
--
K
WP---
R
--
E
-----
K
A
E
A
K
-
A
M
E
L
L
D
K
V
--
G
L
K
D
-
K
--
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
-
R
E
-
V
G
D
-
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
80.82
35%
-101
- C1 -
2OLK
2
?
B:
[24-243]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
----
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
-
K
V
R
E
-----------
E
V
G
M
V
F
Q
--
R
F
N
--
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A----
P
M
-
K
V
R
--
K
WP---
R
--
E
-----
K
A
E
A
K
-
A
M
E
L
L
D
K
V
--
G
L
K
D
-
K
--
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
-
R
E
-
V
G
D
-
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
80.43
35%
-101
- C1 -
2OLK
1
?
C:
[24-243]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
----
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
-
K
V
R
E
-----------
E
V
G
M
V
F
Q
--
R
F
N
--
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A----
P
M
-
K
V
R
--
K
WP---
R
--
E
-----
K
A
E
A
K
-
A
M
E
L
L
D
K
V
--
G
L
K
D
-
K
--
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
-
R
E
-
V
G
D
-
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
80.19
35%
-99
- C1 -
2OLK
1
?
D:
[24-243]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
----
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
-
K
V
R
E
-----------
E
V
G
M
V
F
Q
--
R
F
N
--
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A----
P
M
-
K
V
R
--
K
WP---
R
--
E
-----
K
A
E
A
K
-
A
M
E
L
L
D
K
V
--
G
L
K
D
-
K
--
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
-
R
E
-
V
G
D
-
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
79.45
35%
-101
- C1 -
2OLK
1
?
A:
[24-243]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
----
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
-
K
V
R
E
-----------
E
V
G
M
V
F
Q
--
R
F
N
--
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A----
P
M
-
K
V
R
--
K
WP---
R
--
E
-----
K
A
E
A
K
-
A
M
E
L
L
D
K
V
--
G
L
K
D
-
K
--
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
-
R
E
-
V
G
D
-
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
79.40
35%
-103
- C1 -
3C4J
4
?
B:
[24-243]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
----
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
-
K
V
R
E
-----------
E
V
G
M
V
F
Q
--
R
F
N
--
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A----
P
M
-
K
V
R
--
K
WP---
R
--
E
-----
K
A
E
A
K
-
A
M
E
L
L
D
K
V
--
G
L
K
D
-
K
--
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
-
R
E
-
V
G
D
-
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
78.99
35%
-97
- C1 -
3C41
3
?
K:
[3-222]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
----
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
-
K
V
R
E
-----------
E
V
G
M
V
F
Q
--
R
F
N
--
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A----
P
M
-
K
V
R
--
K
WP---
R
--
E
-----
K
A
E
A
K
-
A
M
E
L
L
D
K
V
--
G
L
K
D
-
K
--
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
-
R
E
-
V
G
D
-
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
78.57
35%
-101
- C1 -
3C4J
3
?
A:
[24-243]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
----
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
-
K
V
R
E
-----------
E
V
G
M
V
F
Q
--
R
F
N
--
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
----
P
M
-
K
V
R
--
K
WP---
R
--
E
-----
K
A
E
A
K
-
A
M
E
L
L
D
K
V
--
G
L
K
D
-
K
--
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
-
R
E
-
V
G
D
-
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
78.08
35%
-98
- C1 -
2Q0H
4
?
A:
[24-243]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
----
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
-
K
V
R
E
-----------
E
V
G
M
V
F
Q
--
R
F
N
--
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
----
P
M
-
K
V
R
--
K
WP---
R
--
E
-----
K
A
E
A
K
-
A
M
E
L
L
D
K
V
--
G
L
K
D
-
K
--
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
-
R
E
-
V
G
D
-
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
77.33
35%
-98
- C1 -
2Q0H
4
?
B:
[24-243]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
----
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
-
K
V
R
E
-----------
E
V
G
M
V
F
Q
--
R
F
N
--
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A----
P
M
-
K
V
R
--
K
WP---
R
--
E
-----
K
A
E
A
K
-
A
M
E
L
L
D
K
V
--
G
L
K
D
-
K
--
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
-
R
E
-
V
G
D
-
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
77.16
35%
-92
- C1 -
3C41
3
?
J:
[3-222]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
----
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
-
K
V
R
E
-----------
E
V
G
M
V
F
Q
--
R
F
N
--
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A----
P
M
-
K
V
R
--
K
WP---
R
--
E
-----
K
A
E
A
K
-
A
M
E
L
L
D
K
V
--
G
L
K
D
-
K
--
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
-
R
E
-
V
G
D
-
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
76.43
35%
-94
- C1 -
2OLJ
3
?
B:
[24-243]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
----
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
-
K
V
R
E
-----------
E
V
G
M
V
F
Q
--
R
F
N
--
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A----
P
M
-
K
V
R
--
K
WP---
R
--
E
-----
K
A
E
A
K
-
A
M
E
L
L
D
K
V
--
G
L
K
D
-
K
--
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
-
R
E
-
V
G
D
-
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
72.08
36%
-102
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[19-223]
-----------------------
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
----
G
E
I
S
L
S
G
K
T
I
--
F
S
K
N
T
N
L
P
V
R
E
R
----------
R
L
G
Y
L
V
Q
--
E
G
V
--
L
F
P
H
L
T
V
Y
R
N
I
A
-
Y
-----
G
L
G
N
G
K
--
G
-----
R
T-
A
-----
Q
E
R
Q
R
-
I
E
A
M
L
E
L
T
--
G
I
S
E
-
L
--
A
-
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
-
Q
Y
-
A
-
D
-
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
70.47
36%
-101
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[19-228]
-----------------------
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
----
G
E
I
S
L
S
G
K
T
I
--
F
S
K
N
T
N
L
P
V
R
E
R
----------
R
L
G
Y
L
V
Q
--
E
G
V
--
L
F
P
H
L
T
V
Y
R
N
I
A
-
Y
-----
G
L
G
N
G
K
--
G
-----
R
T-
A
-----
Q
E
R
Q
R
-
I
E
A
M
L
E
L
T
--
G
I
S
E
-
L
--
A
-
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
-
Q
Y
-
A
-
D
-
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
69.32
34%
-102
- C1 -
4FWI
2
?
B:
[4-224]
----
I
I
R
V
E
D
L
R
A
V
Y
L
V
R
E
G
T
I
K
A
A
D
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
L
P
P
N
G
RILS
G
R
V
L
Y
K
G
K
D
L
L
T
M
R
E
E
E
L
R
K
I
R
W
K
----------
E
I
A
L
V
P
Q
--
A
A
Q
QS
L
N
P
T
M
K
V
I
E
H
F
K
-
D
-----
T
V
-
E
A
H
--
G
VRWS-
H
--
S
-----
E
L
I
E
K
-
A
S
E
K
L
R
M
V
--
R
L
N
P
-
E
AV
L
-
N
S
Y
P
L
Q
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
-----------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
55.18
32%
-76
- C1 -
2IXF
4
TAP1_RAT
C:
[31-237]
--------------------
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
----
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
-
H
Y
L
H
T
Q
V
A
----------
A
V
G
------
Q
E
P
--
L
L
F
G
R
S
F
R
E
N
I
A
-
Y
G
L
T
R
T
P
T
-
M
E
E
--
I
-----
T
--
A
-----
V
A
M
E
S
G
A
H
D
F
I
S
G
F
PQ
G
Y
D
T
-
E
--
V
-
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
H
Q
-
L
S
L
A
-
E
R
-
A
-
H
-
H
I
L
F
L
K
E
G
S
V
C
E
Q
---------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
54.03
33%
-97
- C1 -
1VCI
1
?
A:
[16-209]
--------
E
N
L
T
K
R
F
G
N
----
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
----
G
R
I
Y
F
G
D
R
D
V
T
Y
L
P
P
K
D
R
----------------
N
I
S
M
V
F
Q
----------
H
M
T
V
Y
E
N
I
A
-
F
-----
P
L
---
K
--
K
FP---
K
--
D
-----
E
I
D
K
R
-
V
R
W
A
A
E
L
L
--
Q
I
E
E
-
L
--
L
-
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
-
Q
---------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
52.41
32%
-78
- C1 -
2IXF
4
D:
[31-237]
--------------------
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
----
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
-
H
Y
L
H
T
Q
V
A
----------
A
V
G
------
Q
----
L
L
F
G
R
S
F
R
E
N
I
A
-
Y
GLTRT
P
T
-
M
E
E
--
I
-----
T
--
A
-----
V
A
M
E
S
G
A
H
D
F
I
S
G
F
PQ
G
Y
D
T
-
E
--
V
-
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
H
Q
-
L
S
L
A
-
E
R
-
A
-
H
-
H
I
L
F
L
K
E
G
S
V
C
E
Q
---------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
51.84
35%
-104
- C1 -
4HLU
2
ECFA1_THEMA
D:
[26-199]
-----------------------
V
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
-
L
A
A
A
----
G
E
I
F
L
D
G
S
P
A
D
P
F
-------
L
L
R
K
----------
N
V
G
Y
V
F
Q
NP
S
S
Q
--
I
I
G
A
-
T
V
E
E
D
V
A
-
F
-----
S
L
-
E
I
M
--
G
LD---
E
--
S
-----
E
M
R
K
R
-
I
K
K
V
L
E
L
V
--
G
L
S
G
-
L
--
A
-
A
A
D
P
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
E
S
L
K
N
E
-
G
K
G
I
I
L
V
T
H
E
-----------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
51.20
35%
-103
- C1 -
4HLU
3
ECFA1_THEMA
C:
[26-199]
-----------------------
V
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
-
L
A
A
A
----
G
E
I
F
L
D
G
S
P
A
D
P
F
-------
L
L
R
K
----------
N
V
G
Y
V
F
Q
NP
S
S
Q
--
I
I
G
A
-
T
V
E
E
D
V
A
-
F
-----
S
L
-
E
I
M
--
G
LD---
E
--
S
-----
E
M
R
K
R
-
I
K
K
V
L
E
L
V
--
G
L
S
G
-
L
--
A
-
A
A
D
P
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
E
S
L
K
N
E
-
G
K
G
I
I
L
V
T
H
E
-----------------------------------------------------------------------------------------------------------------------------------------------