@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2887: (2016-02-11 )
MSYDSIFRPGLFDGQTIIVTGGGSGIGRCTAHELAALGAHVVLVGRKAEKLEKTAGEIVEDGGSVSWHACDIREEEAVKTLVANILAERGTIHHLVNNAGGQYPSPLASISQKGFETVLRTNLVGGFLVAREVFNQSMSKTGGSIVNMLADMWGGMPGMGHSGAARSGMENFTRTAAVEWGHAGVRVNAVAPGWIASSGMDTYEGAFKAVIPTLREHVPLKRIGSESEVAAAIVFLLSPGAAFVSGNTIRIDGAASQGSRAFPLFKGKPGQSRAYNGFHRAYLPDVLKDQED
Atome Classification :
(20 SA)
.........10........20........30........40........50........60----.-----.......-.70........80........90........100..-.....110-------.........120.......130.......140.......--.150..--.-.--...160.......170.......180-.......190...-------------...---------.200...-....210.......220.......230.......240.......250.......260.......270.......280.......290
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
Y
D
S
IFRPGLFDG
Q
T
I
I
V
TGGGSG
I
G
R
C
T
A
H
E
L
A
A
LG
A
H
V
V
L
VG
R
K
A
E
K
L
E
K
T
A
G
E
I
V
E-----D-----GGS
V
S
W
H
-
A
CD
I
R
E
E
E
A
V
K
T
L
V
A
N
I
L
AERG
T
I
H
H
L
V
NNAGGQYP-
S
P
L
A
S
I
---------
S
Q
K
G
F
E
T
V
L
R
T
NLV
G
G
F
L
V
A
R
E
V
F
N
Q
S
M
S
K-T
G
G
S
I
V
N
M
--
L
A
D
M
WG--G-M--PGMGHS
G
A
A
R
S
G
M
E
N
F
T
R
T
A
A
V
EWGH-A
G
V
R
V
N
A
VAPGWI-------------ASS---------GM
D
T
Y
E
G
-
A
F
K
A
V
I
P
T
L
R
EHV
P
L
K
RIGS
E
S
E
V
A
A
A
I
V
F
L
LSPGA
A
F
VSG
N
T
I
R
IDGAASQGSRAFPLFKGKPGQSRAYNG
F
H
R
A
Y
L
P
D
V
LKDQED
1
PsiBlast_PDB
94.00
40%
-109
- C1 -
1YXM
1
PECR_HUMAN
A:
[9-272]
----
S
Y
L
A
P
G
L
L
Q
G
Q
V
A
I
V
T
G
G
A
T
G
I
G
K
A
I
V
K
E
L
L
E
L
G
S
N
V
V
I
A
S
R
K
L
E
R
L
K
S
A
A
D
E
L
Q
A
-----
N
LPPTK
Q
A
R
V
I
P
I
-
Q
C
N
I
R
N
E
E
E
V
N
N
L
V
K
S
T
L
D
T
F
G
K
I
N
F
L
V
N
N
G
G
G
Q
F
L
-
S
P
A
E
H
I
---------
S
S
K
G
W
H
A
V
L
E
T
N
L
T
G
T
F
Y
M
C
K
A
V
Y
S
S
W
M
K
E
-
H
G
G
S
I
V
N
I
--
I
V
P
T
K
A
--
G
-
F
--
P
L
A
V
H
S
G
A
A
R
A
G
V
Y
N
L
T
K
S
L
A
L
E
W
A
C
-
S
G
I
R
I
N
C
V
A
P
G
V
I
-------------
Y
S
Q
TAVENYG
S
W
G
Q
S
F
F
E
G
-
S
F
--------
Q
K
I
P
A
K
R
I
G
V
P
E
E
V
S
S
V
V
C
F
L
L
S
P
A
A
S
F
I
T
G
Q
S
V
D
V
D
G
G
R
S
L
Y
T
H
S
Y
------------------------------
22
PsiBlast_CBE
92.75
40%
-108
- C1 -
1YXM
3
PECR_HUMAN
B:
[9-272]
----
S
Y
L
A
P
G
L
L
Q
G
Q
V
A
I
V
T
G
G
A
T
G
I
G
K
A
I
V
K
E
L
L
E
L
G
S
N
V
V
I
A
S
R
K
L
E
R
L
K
S
A
A
D
E
L
Q
A
-----
N
L
PPTK
Q
A
R
V
I
P
I
-
Q
C
N
I
R
N
E
E
E
V
N
N
L
V
K
S
T
L
D
T
F
G
K
I
N
F
L
V
N
N
G
G
G
Q
F
L
-
S
P
A
E
H
I
---------
S
S
K
G
W
H
A
V
L
E
T
N
L
T
G
T
F
Y
M
C
K
A
V
Y
S
S
W
M
K
E
-
H
G
G
S
I
V
N
I
--
I
V
P
T
K
A
--
G
-
F
--
P
L
A
V
H
S
G
A
A
R
A
G
V
Y
N
L
T
K
S
L
A
L
E
W
A
C
-
S
G
I
R
I
N
C
V
A
P
G
V
I
-------------
Y
S
Q
TA--------
Q
S
F
F
E
G
-
S
F
--------
Q
K
I
P
A
K
R
I
G
V
P
E
E
V
S
S
V
V
C
F
L
L
S
P
A
A
S
F
I
T
G
Q
S
V
D
V
D
G
G
R
S
L
Y
T
H
S
Y
------------------------------
21
PsiBlast_CBE
92.71
40%
-104
- C1 -
1YXM
2
PECR_HUMAN
D:
[9-272]
----
S
Y
L
A
P
G
L
L
Q
G
Q
V
A
I
V
T
G
G
A
T
G
I
G
K
A
I
V
K
E
L
L
E
L
G
S
N
V
V
I
A
S
R
K
L
E
R
L
K
S
A
A
D
E
L
Q
A
-----
N
L-----
A
R
V
I
P
I
-
Q
C
N
I
R
N
E
E
E
V
N
N
L
V
K
S
T
L
D
T
F
G
K
I
N
F
L
V
N
N
G
G
G
Q
F
L
-
S
P
A
E
H
I
---------
S
S
K
G
W
H
A
V
L
E
T
N
L
T
G
T
F
Y
M
C
K
A
V
Y
S
S
W
M
K
E
-
H
G
G
S
I
V
N
I
--
I
V
P
T
K
A
--
G
-
F
--
P
L
A
V
H
S
G
A
A
R
A
G
V
Y
N
L
T
K
S
L
A
L
E
W
A
C
-
S
G
I
R
I
N
C
V
A
P
G
V
I
-------------
Y
S
Q
T
A
V
E
N
Y
GSW
G
Q
S
F
F
E
G
-
S
F
--------
Q
K
I
P
A
K
R
I
G
V
P
E
E
V
S
S
V
V
C
F
L
L
S
P
A
A
S
F
I
T
G
Q
S
V
D
V
D
G
G
R
S
L
Y
T
H
S
Y
------------------------------
101
HHSearch
89.99
41%
-104
- C1 -
1YXM
1
PECR_HUMAN
A:
[12-277]
-------
A
P
G
L
L
Q
G
Q
V
A
I
V
T
G
G
A
T
G
I
G
K
A
I
V
K
E
L
L
E
L
G
S
N
V
V
I
A
S
R
K
L
E
R
L
K
S
A
A
D
E
L
Q
A
N
LPPT
K
-----
Q
A
R
V
I
P
I
-
Q
C
N
I
R
N
E
E
E
V
N
N
L
V
K
S
T
L
D
T
F
G
K
I
N
F
L
V
N
N
G
G
G
Q
F
L
-
S
P
A
E
H
I
---------
S
S
K
G
W
H
A
V
L
E
T
N
L
T
G
T
F
Y
M
C
K
A
V
Y
S
S
W
M
K
E
-
H
G
G
S
I
V
N
I
--
I
-
V
P
T
K
--
A
G
F
--
P
L
A
V
H
S
G
A
A
R
A
G
V
Y
N
L
T
K
S
L
A
L
E
W
A
C
-
S
G
I
R
I
N
C
V
A
P
G
V
I
-------------
Y
S
Q
---------
T
A
V
E
N
Y
G
S
W
G
Q
S
F
F
E
G
S
F
Q
K
I
P
A
K
R
I
G
V
P
E
E
V
S
S
V
V
C
F
L
L
S
P
A
A
S
F
I
T
G
Q
S
V
D
V
D
G
G
R
S
L
Y
T
H
S
Y
E
V
P
D
H
-------------------------
34
PsiBlast_CBE
81.96
31%
-96
- C1 -
1ZEM
1
?
C:
[5-261]
-----------
F
N
G
K
V
C
L
V
T
G
A
G
G
N
I
G
L
A
T
A
L
R
L
A
E
E
G
T
A
I
A
L
L
D
M
N
R
E
A
L
E
K
A
E
A
S
V
R
E
-----
K
-----
G
V
E
A
R
S
Y
-
V
C
D
V
T
S
E
E
A
V
I
G
T
V
D
S
V
V
R
D
F
G
K
I
D
F
L
F
N
N
A
G
Y
Q
G
A
F
A
P
V
Q
D
Y
---------
P
S
D
D
F
A
R
V
L
T
I
N
V
T
G
A
F
H
V
L
K
A
V
S
R
Q
M
I
T
Q
-
N
Y
G
R
I
V
N
T
---
A
S
M
A
G
VK
G
-
P
--
P
N
M
A
A
Y
G
T
S
K
G
A
I
I
A
L
T
E
T
A
A
L
D
L
A
P
-
Y
N
I
R
V
N
A
I
S
P
G
Y
M
GPGFMWERQVELQ
A
K
V
---------
G
S
Q
Y
F
S
T
-
D
P
K
V
V
A
Q
Q
M
I
G
S
V
P
M
R
R
Y
G
D
I
N
E
I
P
G
V
V
A
F
L
L
G
D
D
S
S
F
M
T
G
V
N
L
P
I
A
G
---------------------------------------
33
PsiBlast_CBE
81.40
31%
-96
- C1 -
1ZEM
1
?
D:
[5-261]
-----------
F
N
G
K
V
C
L
V
T
G
A
G
G
N
I
G
L
A
T
A
L
R
L
A
E
E
G
T
A
I
A
L
L
D
M
N
R
E
A
L
E
K
A
E
A
S
V
R
E
-----
K
-----
G
V
E
A
R
S
Y
-
V
C
D
V
T
S
E
E
A
V
I
G
T
V
D
S
V
V
R
D
F
G
K
I
D
F
L
F
N
N
A
G
Y
Q
G
A
F
A
P
V
Q
D
Y
---------
P
S
D
D
F
A
R
V
L
T
I
N
V
T
G
A
F
H
V
L
K
A
V
S
R
Q
M
I
T
Q
-
N
Y
G
R
I
V
N
T
---
A
S
M
A
G
VK
G
-
P
--
P
N
M
A
A
Y
G
T
S
K
G
A
I
I
A
L
T
E
T
A
A
L
D
L
A
P
-
Y
N
I
R
V
N
A
I
S
P
G
Y
M
GPGFMWERQVELQ
A
K
V
---------
G
S
Q
Y
F
S
T
-
D
P
K
V
V
A
Q
Q
M
I
G
S
V
P
M
R
R
Y
G
D
I
N
E
I
P
G
V
V
A
F
L
L
G
D
D
S
S
F
M
T
G
V
N
L
P
I
A
G
---------------------------------------
31
PsiBlast_CBE
81.08
31%
-94
- C1 -
1ZEM
1
?
F:
[5-261]
-----------
F
N
G
K
V
C
L
V
T
G
A
G
G
N
I
G
L
A
T
A
L
R
L
A
E
E
G
T
A
I
A
L
L
D
M
N
R
E
A
L
E
K
A
E
A
S
V
R
E
-----
K
-----
G
V
E
A
R
S
Y
-
V
C
D
V
T
S
E
E
A
V
I
G
T
V
D
S
V
V
R
D
F
G
K
I
D
F
L
F
N
N
A
G
Y
Q
G
A
F
A
P
V
Q
D
Y
---------
P
S
D
D
F
A
R
V
L
T
I
N
V
T
G
A
F
H
V
L
K
A
V
S
R
Q
M
I
T
Q
-
N
Y
G
R
I
V
N
T
---
A
S
M
A
G
VK
G
-
P
--
P
N
M
A
A
Y
G
T
S
K
G
A
I
I
A
L
T
E
T
A
A
L
D
L
A
P
-
Y
N
I
R
V
N
A
I
S
P
G
Y
M
GPGFMWERQVELQ
A
K
V
---------
G
S
Q
Y
F
S
T
-
D
P
K
V
V
A
Q
Q
M
I
G
S
V
P
M
R
R
Y
G
D
I
N
E
I
P
G
V
V
A
F
L
L
G
D
D
S
S
F
M
T
G
V
N
L
P
I
A
G
---------------------------------------
35
PsiBlast_CBE
80.92
31%
-93
- C1 -
1ZEM
1
?
B:
[5-261]
-----------
F
N
G
K
V
C
L
V
T
G
A
G
G
N
I
G
L
A
T
A
L
R
L
A
E
E
G
T
A
I
A
L
L
D
M
N
R
E
A
L
E
K
A
E
A
S
V
R
E
-----
K
-----
G
V
E
A
R
S
Y
-
V
C
D
V
T
S
E
E
A
V
I
G
T
V
D
S
V
V
R
D
F
G
K
I
D
F
L
F
N
N
A
G
Y
Q
G
A
F
A
P
V
Q
D
Y
---------
P
S
D
D
F
A
R
V
L
T
I
N
V
T
G
A
F
H
V
L
K
A
V
S
R
Q
M
I
T
Q
-
N
Y
G
R
I
V
N
T
---
A
S
M
A
G
VK
G
-
P
--
P
N
M
A
A
Y
G
T
S
K
G
A
I
I
A
L
T
E
T
A
A
L
D
L
A
P
-
Y
N
I
R
V
N
A
I
S
P
G
Y
M
GPGFMWERQVELQ
A
K
V
---------
G
S
Q
Y
F
S
T
-
D
P
K
V
V
A
Q
Q
M
I
G
S
V
P
M
R
R
Y
G
D
I
N
E
I
P
G
V
V
A
F
L
L
G
D
D
S
S
F
M
T
G
V
N
L
P
I
A
G
---------------------------------------
62
PsiBlast_CBE
80.73
33%
-94
- C1 -
4NBW
1
?
C:
[5-257]
-------------
K
R
V
A
I
I
T
G
A
A
N
G
I
G
R
A
T
A
L
E
F
A
Q
A
G
Y
H
V
V
A
W
D
L
A
E
E
A
G
A
A
L
I
A
E
I
A
D
-----
A
-----
G
G
S
A
D
F
A
-
R
V
D
V
S
A
A
E
S
V
E
A
A
V
A
E
I
I
A
E
H
G
R
V
D
V
L
V
N
N
A
G
I
L
H
D
-
G
Q
L
V
K
V
KGGEVVKKM
A
E
A
Q
F
D
A
V
I
S
V
N
L
K
G
V
F
L
C
T
Q
A
V
A
P
H
M
I
A
A
-
K
Y
G
R
I
L
N
A
SS
V
V
G
L
Y
G
--
N
-
F
---
G
Q
T
N
Y
V
A
A
K
S
G
V
I
G
M
T
K
V
W
A
R
E
L
G
R
-
Y
G
I
T
V
N
A
I
A
P
G
F
I
-------------
A
T
------------
E
M
V
Q
Q
-
M
P
E
R
V
L
E
A
M
V
A
R
T
P
V
G
R
I
G
D
P
V
D
I
A
R
A
Y
L
F
L
A
S
E
E
S
G
F
I
S
G
T
T
L
S
V
D
G
G
M
V
V
G
S
---------------------------------
29
PsiBlast_CBE
80.54
31%
-93
- C1 -
1ZEM
1
?
H:
[5-261]
-----------
F
N
G
K
V
C
L
V
T
G
A
G
G
N
I
G
L
A
T
A
L
R
L
A
E
E
G
T
A
I
A
L
L
D
M
N
R
E
A
L
E
K
A
E
A
S
V
R
E
-----
K
-----
G
V
E
A
R
S
Y
-
V
C
D
V
T
S
E
E
A
V
I
G
T
V
D
S
V
V
R
D
F
G
K
I
D
F
L
F
N
N
A
G
Y
Q
G
A
F
A
P
V
Q
D
Y
---------
P
S
D
D
F
A
R
V
L
T
I
N
V
T
G
A
F
H
V
L
K
A
V
S
R
Q
M
I
T
Q
-
N
Y
G
R
I
V
N
T
---
A
S
M
A
G
VK
G
-
P
--
P
N
M
A
A
Y
G
T
S
K
G
A
I
I
A
L
T
E
T
A
A
L
D
L
A
P
-
Y
N
I
R
V
N
A
I
S
P
G
Y
M
GPGFMWERQVELQ
A
K
V
---------
G
S
Q
Y
F
S
T
-
D
P
K
V
V
A
Q
Q
M
I
G
S
V
P
M
R
R
Y
G
D
I
N
E
I
P
G
V
V
A
F
L
L
G
D
D
S
S
F
M
T
G
V
N
L
P
I
A
G
---------------------------------------
63
PsiBlast_CBE
80.40
33%
-96
- C1 -
4NBW
1
?
B:
[5-257]
-------------
K
R
V
A
I
I
T
G
A
A
N
G
I
G
R
A
T
A
L
E
F
A
Q
A
G
Y
H
V
V
A
W
D
L
A
E
E
A
G
A
A
L
I
A
E
I
A
D
-----
A
-----
G
G
S
A
D
F
A
-
R
V
D
V
S
A
A
E
S
V
E
A
A
V
A
E
I
I
A
E
H
G
R
V
D
V
L
V
N
N
A
G
I
L
H
D
-
G
Q
L
V
K
V
KGGEVVKKM
A
E
A
Q
F
D
A
V
I
S
V
N
L
K
G
V
F
L
C
T
Q
A
V
A
P
H
M
I
A
A
-
K
Y
G
R
I
L
N
A
SS
V
V
G
L
Y
G
--
N
-
F
---
G
Q
T
N
Y
V
A
A
K
S
G
V
I
G
M
T
K
V
W
A
R
E
L
G
R
-
Y
G
I
T
V
N
A
I
A
P
G
F
I
-------------
A
T
------------
E
M
V
Q
Q
-
M
P
E
R
V
L
E
A
M
V
A
R
T
P
V
G
R
I
G
D
P
V
D
I
A
R
A
Y
L
F
L
A
S
E
E
S
G
F
I
S
G
T
T
L
S
V
D
G
G
M
V
V
G
S
---------------------------------
61
PsiBlast_CBE
80.35
33%
-92
- C1 -
4NBW
1
?
D:
[5-257]
-------------
K
R
V
A
I
I
T
G
A
A
N
G
I
G
R
A
T
A
L
E
F
A
Q
A
G
Y
H
V
V
A
W
D
L
A
E
E
A
G
A
A
L
I
A
E
I
A
D
-----
A
-----
G
G
S
A
D
F
A
-
R
V
D
V
S
A
A
E
S
V
E
A
A
V
A
E
I
I
A
E
H
G
R
V
D
V
L
V
N
N
A
G
I
L
H
D
-
G
Q
L
V
K
V
KGGEVVKKM
A
E
A
Q
F
D
A
V
I
S
V
N
L
K
G
V
F
L
C
T
Q
A
V
A
P
H
M
I
A
A
-
K
Y
G
R
I
L
N
A
SS
V
V
G
L
Y
G
--
N
-
F
---
G
Q
T
N
Y
V
A
A
K
S
G
V
I
G
M
T
K
V
W
A
R
E
L
G
R
-
Y
G
I
T
V
N
A
I
A
P
G
F
I
-------------
A
T
------------
E
M
V
Q
Q
-
M
P
E
R
V
L
E
A
M
V
A
R
T
P
V
G
R
I
G
D
P
V
D
I
A
R
A
Y
L
F
L
A
S
E
E
S
G
F
I
S
G
T
T
L
S
V
D
G
G
M
V
V
G
S
---------------------------------
30
PsiBlast_CBE
80.04
31%
-90
- C1 -
1ZEM
1
?
G:
[5-261]
-----------
F
N
G
K
V
C
L
V
T
G
A
G
G
N
I
G
L
A
T
A
L
R
L
A
E
E
G
T
A
I
A
L
L
D
M
N
R
E
A
L
E
K
A
E
A
S
V
R
E
-----
K
-----
G
V
E
A
R
S
Y
-
V
C
D
V
T
S
E
E
A
V
I
G
T
V
D
S
V
V
R
D
F
G
K
I
D
F
L
F
N
N
A
G
Y
Q
G
A
F
A
P
V
Q
D
Y
---------
P
S
D
D
F
A
R
V
L
T
I
N
V
T
G
A
F
H
V
L
K
A
V
S
R
Q
M
I
T
Q
-
N
Y
G
R
I
V
N
T
---
A
S
M
A
G
VK
G
-
P
--
P
N
M
A
A
Y
G
T
S
K
G
A
I
I
A
L
T
E
T
A
A
L
D
L
A
P
-
Y
N
I
R
V
N
A
I
S
P
G
Y
M
GPGFMWERQVELQ
A
K
V
---------
G
S
Q
Y
F
S
T
-
D
P
K
V
V
A
Q
Q
M
I
G
S
V
P
M
R
R
Y
G
D
I
N
E
I
P
G
V
V
A
F
L
L
G
D
D
S
S
F
M
T
G
V
N
L
P
I
A
G
---------------------------------------
32
PsiBlast_CBE
79.93
31%
-94
- C1 -
1ZEM
1
?
E:
[5-261]
-----------
F
N
G
K
V
C
L
V
T
G
A
G
G
N
I
G
L
A
T
A
L
R
L
A
E
E
G
T
A
I
A
L
L
D
M
N
R
E
A
L
E
K
A
E
A
S
V
R
E
-----
K
-----
G
V
E
A
R
S
Y
-
V
C
D
V
T
S
E
E
A
V
I
G
T
V
D
S
V
V
R
D
F
G
K
I
D
F
L
F
N
N
A
G
Y
Q
G
A
F
A
P
V
Q
D
Y
---------
P
S
D
D
F
A
R
V
L
T
I
N
V
T
G
A
F
H
V
L
K
A
V
S
R
Q
M
I
T
Q
-
N
Y
G
R
I
V
N
T
---
A
S
M
A
G
VK
G
-
P
--
P
N
M
A
A
Y
G
T
S
K
G
A
I
I
A
L
T
E
T
A
A
L
D
L
A
P
-
Y
N
I
R
V
N
A
I
S
P
G
Y
M
GPGFMWERQVELQ
A
K
V
---------
G
S
Q
Y
F
S
T
-
D
P
K
V
V
A
Q
Q
M
I
G
S
V
P
M
R
R
Y
G
D
I
N
E
I
P
G
V
V
A
F
L
L
G
D
D
S
S
F
M
T
G
V
N
L
P
I
A
G
---------------------------------------
8
PsiBlast_PDB
79.35
31%
-92
- C1 -
1ZEM
1
?
A:
[5-261]
-----------
F
N
G
K
V
C
L
V
T
G
A
G
G
N
I
G
L
A
T
A
L
R
L
A
E
E
G
T
A
I
A
L
L
D
M
N
R
E
A
L
E
K
A
E
A
S
V
R
E
-----
K
-----
G
V
E
A
R
S
Y
-
V
C
D
V
T
S
E
E
A
V
I
G
T
V
D
S
V
V
R
D
F
G
K
I
D
F
L
F
N
N
A
G
Y
Q
G
A
F
A
P
V
Q
D
Y
---------
P
S
D
D
F
A
R
V
L
T
I
N
V
T
G
A
F
H
V
L
K
A
V
S
R
Q
M
I
T
Q
-
N
Y
G
R
I
V
N
T
---
A
S
M
A
G
V
K
G
-
P
--
P
N
M
A
A
Y
G
T
S
K
G
A
I
I
A
L
T
E
T
A
A
L
D
L
A
P
-
Y
N
I
R
V
N
A
I
S
P
G
Y
M
GPG
F
M
W
E
R
Q
V
E
L
Q
A
K
V
---------
G
S
Q
Y
F
S
T
-
D
P
K
V
V
A
Q
Q
M
I
G
S
V
P
M
R
R
Y
G
D
I
N
E
I
P
G
V
V
A
F
L
L
G
D
D
S
S
F
M
T
G
V
N
L
P
I
A
G
---------------------------------------
118
HHSearch
78.30
33%
-95
- C1 -
3IMF
-
?
A:
[3-253]
----------
A
M
K
E
K
V
V
I
I
T
G
G
S
S
G
M
G
K
G
M
A
T
R
F
A
K
E
G
A
R
V
V
I
T
G
R
T
K
E
K
L
E
E
A
K
L
E
I
E
Q
-----
F
-----
P
G
Q
I
L
T
V
-
Q
M
D
V
R
N
T
D
D
I
Q
K
M
I
E
Q
I
D
E
K
F
G
R
I
D
I
L
I
N
N
A
A
G
N
F
I
-
C
P
A
E
D
L
---------
S
V
N
G
W
N
S
V
I
N
I
V
L
N
G
T
F
Y
C
S
Q
A
I
G
K
Y
W
I
E
K
G
I
K
G
N
I
I
N
M
--
V
-
A
T
Y
A
--
W
-
D
AG
P
G
V
I
H
S
A
A
A
K
A
G
V
L
A
M
T
K
T
L
A
V
E
W
G
R
K
Y
G
I
R
V
N
A
I
A
P
G
P
I
-------------
E
R
T
---------
G
G
A
--------
E
M
A
K
R
T
I
Q
S
V
P
L
G
R
L
G
T
P
E
E
I
A
G
L
A
Y
Y
L
C
S
D
E
A
A
Y
I
N
G
T
C
M
T
M
D
G
G
Q
H
L
H
----------------------------------
2
PsiBlast_PDB
78.15
32%
-95
- C1 -
4FC6
2
DECR2_HUMAN
A:
[15-270]
-
A
Y
R
H
L
F
C
P
D
L
L
R
D
K
V
A
F
I
T
G
G
G
S
G
I
G
F
R
I
A
E
I
F
M
R
H
G
C
H
T
V
I
A
S
R
S
L
P
R
V
L
T
A
A
R
K
L
A
G
-----
A
-----
T
G
R
R
C
L
P
L
S
M
D
V
R
A
P
P
A
V
M
A
A
V
D
Q
A
L
K
E
F
G
R
I
D
I
L
I
N
C
A
A
G
N
F
L
-
C
P
A
G
A
L
---------
S
F
N
A
F
K
T
V
M
D
I
D
T
S
G
T
F
N
V
S
R
V
L
Y
E
K
F
F
R
D
-
H
G
G
V
I
V
N
I
--
T
A
T
L
G
N
R-
G
-
Q
--
A
L
Q
V
H
A
G
S
A
K
A
A
V
D
A
M
T
R
H
L
A
V
E
W
G
P
-
Q
N
I
R
V
N
S
L
A
P
G
P
I
-------------
S
G
T
---------
E
G
L
R
R
L
G
-
G
P
Q
A
S
L
S
T
K
V
T
A
S
P
L
Q
R
L
G
N
K
T
E
I
A
H
S
V
L
Y
L
A
S
P
L
A
S
Y
V
T
G
A
V
L
V
A
D
G
G
A
-------------------------------------
24
PsiBlast_CBE
77.68
32%
-96
- C1 -
4FC7
2
DECR2_HUMAN
C:
[15-270]
-
A
Y
R
H
L
F
C
P
D
L
L
R
D
K
V
A
F
I
T
G
G
G
S
G
I
G
F
R
I
A
E
I
F
M
R
H
G
C
H
T
V
I
A
S
R
S
L
P
R
V
L
T
A
A
R
K
L
A
G
-----
A
-----
T
G
R
R
C
L
P
L
S
M
D
V
R
A
P
P
A
V
M
A
A
V
D
Q
A
L
K
E
F
G
R
I
D
I
L
I
N
C
A
A
G
N
F
L
-
C
P
A
G
A
L
---------
S
F
N
A
F
K
T
V
M
D
I
D
T
S
G
T
F
N
V
S
R
V
L
Y
E
K
F
F
R
D
-
H
G
G
V
I
V
N
I
--
T
A
T
L
G
N
R-
G
-
Q
--
A
L
Q
V
H
A
G
S
A
K
A
A
V
D
A
M
T
R
H
L
A
V
E
W
G
P
-
Q
N
I
R
V
N
S
L
A
P
G
P
I
-------------
S
G
T
---------
E
G
L
R
R
L
G
-
G
P
Q
A
S
L
S
T
K
V
T
A
S
P
L
Q
R
L
G
N
K
T
E
I
A
H
S
V
L
Y
L
A
S
P
L
A
S
Y
V
T
G
A
V
L
V
A
D
G
G
A
-------------------------------------
23
PsiBlast_CBE
77.23
32%
-95
- C1 -
4FC7
2
DECR2_HUMAN
D:
[15-270]
-
A
Y
R
H
L
F
C
P
D
L
L
R
D
K
V
A
F
I
T
G
G
G
S
G
I
G
F
R
I
A
E
I
F
M
R
H
G
C
H
T
V
I
A
S
R
S
L
P
R
V
L
T
A
A
R
K
L
A
G
-----
A
-----
T
G
R
R
C
L
P
L
S
M
D
V
R
A
P
P
A
V
M
A
A
V
D
Q
A
L
K
E
F
G
R
I
D
I
L
I
N
C
A
A
G
N
F
L
-
C
P
A
G
A
L
---------
S
F
N
A
F
K
T
V
M
D
I
D
T
S
G
T
F
N
V
S
R
V
L
Y
E
K
F
F
R
D
-
H
G
G
V
I
V
N
I
--
T
A
T
L
G
N
R-
G
-
Q
--
A
L
Q
V
H
A
G
S
A
K
A
A
V
D
A
M
T
R
H
L
A
V
E
W
G
P
-
Q
N
I
R
V
N
S
L
A
P
G
P
I
-------------
S
G
T
---------
E
G
L
R
R
L
G
-
G
P
Q
A
S
L
S
T
K
V
T
A
S
P
L
Q
R
L
G
N
K
T
E
I
A
H
S
V
L
Y
L
A
S
P
L
A
S
Y
V
T
G
A
V
L
V
A
D
G
G
A
-------------------------------------
28
PsiBlast_CBE
77.20
32%
-96
- C1 -
4FC6
2
DECR2_HUMAN
B:
[15-270]
-
A
Y
R
H
L
F
C
P
D
L
L
R
D
K
V
A
F
I
T
G
G
G
S
G
I
G
F
R
I
A
E
I
F
M
R
H
G
C
H
T
V
I
A
S
R
S
L
P
R
V
L
T
A
A
R
K
L
A
G
-----
A
-----
T
G
R
R
C
L
P
L
S
M
D
V
R
A
P
P
A
V
M
A
A
V
D
Q
A
L
K
E
F
G
R
I
D
I
L
I
N
C
A
A
G
N
F
L
-
C
P
A
G
A
L
---------
S
F
N
A
F
K
T
V
M
D
I
D
T
S
G
T
F
N
V
S
R
V
L
Y
E
K
F
F
R
D
-
H
G
G
V
I
V
N
I
--
T
A
T
L
G
N
R-
G
-
Q
--
A
L
Q
V
H
A
G
S
A
K
A
A
V
D
A
M
T
R
H
L
A
V
E
W
G
P
-
Q
N
I
R
V
N
S
L
A
P
G
P
I
-------------
S
G
T
---------
E
G
L
R
R
L
G
-
G
P
Q
A
S
L
S
T
K
V
T
A
S
P
L
Q
R
L
G
N
K
T
E
I
A
H
S
V
L
Y
L
A
S
P
L
A
S
Y
V
T
G
A
V
L
V
A
D
G
G
A
-------------------------------------