@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2890: (2016-02-11 )
MSLPHCETLLLEPIEGVLRITLNRPQSRNAMSLAMVGELRAVLAAVRDDRSVRALVLRGADGHFCAGGDIKDMAGARAAGAEAYRTLNRAFGSLLEEAQAAPQLLVALVEGAVLGGGFGLACVSDVAIAAADAQFGLPETSLGILPAQIAPFVVRRIGLTQARRLALTAARFDGREALRLGLVHFCEADADALEQRLEETLEQLRRCAPNANAATKALLLASESGELGALLDDAARQFAEAVGGAEGSEGTLAFVQKRKPVWAQ
Atome Classification :
(20 SA)
.........10-..-......20...-.....30........40........50........60.-........70---......-..80--------........90........100.......110.......120.......130.-.......140....-...-150....-...-160.......170.......180.......190..------------------------------------------------------------------.....200.......210.......220-......--.-230........240.......250.....--..260..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSLP
H
C
E
T
L
L
L
-
E
P
-
I
E
G
V
L
R
I
T
LNR-PQSRN
A
M
S
L
A
M
V
G
E
L
R
A
V
L
A
A
V
RDDR
S
V
R
A
L
V
L
RGA-D-G
H
F
CAGG
D
I
K
---
D
MAGAR-AA
G
A
--------
E
A
Y
R
T
L
N
R
A
F
G
S
L
L
E
E
A
Q
A
A
P
Q
L
L
V
A
L
V
EGAVLGGG
F
G
L
A
C
V
S
D
V
A
I
A
A-AD-AQFGLPETSLGI
L
P
-
A
Q
I
-
A
P
F
V
V
R
R-I
G
L
-
T
Q
A
R
R
L
A
L
T
AARFD
G
R
E
A
L
R
L
G
L
V
H
FCEA
D
A
D
A
L
E
------------------------------------------------------------------
Q
R
L
E
E
T
L
E
Q
L
R
R
CAPNANAA
T
K
A
L
L
L
AS-ESGE
L
G
--
A
-
L
L
-
D
D
A
A
R
Q
F
A
E
A
VGGAEGSEG
T
L
A
F
V
QK--RKPVWAQ
21
PsiBlast_CBE
91.69
100%
-116
- C3 -
4ZU2
3
?
C:
[7-264]
------
E
T
L
L
L
-
E
P
-
I
E
G
V
L
R
I
T
L
N
R
-
P
Q
S
R
N
A
M
S
L
A
M
V
G
E
L
R
A
V
L
A
A
V
R
D
D
R
S
V
R
A
L
V
L
R
G
A
-
D
-
G
H
F
C
A
G
G
D
I
K
---
D
M
A
G
A
R
-
A
A
G
A
--------
E
A
Y
R
T
L
N
R
A
F
G
S
L
L
E
E
A
Q
A
A
P
Q
L
L
V
A
L
V
E
G
A
V
L
G
G
G
F
G
L
A
C
V
S
D
V
A
I
A
A
-
A
D
-
A
Q
F
G
L
P
E
T
S
L
G
I
L
P
-
A
Q
I
-
A
P
F
V
V
R
R
-
I
G
L
-
T
Q
A
R
R
L
A
L
T
A
A
R
F
D
G
R
E
A
L
R
L
G
L
V
H
F
C
E
A
D
A
D
A
L
E
------------------------------------------------------------------
Q
R
L
E
E
T
L
E
Q
L
R
R
C
A
P
N
A
N
A
A
T
K
A
L
L
L
A
S
-
E
S
G
E
L
G
--
A
-
L
L
-
D
D
A
A
R
Q
F
A
E
A
V
G
G
A
E
G
S
E
G
T
L
A
F
V
Q
K
--
R
K
P
V
W
A
Q
1
PsiBlast_PDB
91.67
100%
-109
- C3 -
4ZU2
6
?
A:
[7-264]
------
E
T
L
L
L
-
E
P
-
I
E
G
V
L
R
I
T
L
N
R
-
P
Q
S
R
N
A
M
S
L
A
M
V
G
E
L
R
A
V
L
A
A
V
R
D
D
R
S
V
R
A
L
V
L
R
G
A
-
D
-
G
H
F
C
A
G
G
D
I
K
---
D
M
A
G
A
R
-
A
A
G
A
--------
E
A
Y
R
T
L
N
R
A
F
G
S
L
L
E
E
A
Q
A
A
P
Q
L
L
V
A
L
V
E
G
A
V
L
G
G
G
F
G
L
A
C
V
S
D
V
A
I
A
A
-
A
D
-
A
Q
F
G
L
P
E
T
S
L
G
I
L
P
-
A
Q
I
-
A
P
F
V
V
R
R
-
I
G
L
-
T
Q
A
R
R
L
A
L
T
A
A
R
F
D
G
R
E
A
L
R
L
G
L
V
H
F
C
E
A
D
A
D
A
L
E
------------------------------------------------------------------
Q
R
L
E
E
T
L
E
Q
L
R
R
C
A
P
N
A
N
A
A
T
K
A
L
L
L
A
S
-
E
S
G
E
L
G
--
A
-
L
L
-
D
D
A
A
R
Q
F
A
E
A
V
G
G
A
E
G
S
E
G
T
L
A
F
V
Q
K
--
R
K
P
V
W
A
Q
22
PsiBlast_CBE
90.99
100%
-113
- C3 -
4ZU2
5
?
B:
[7-264]
------
E
T
L
L
L
-
E
P
-
I
E
G
V
L
R
I
T
L
N
R
-
P
Q
S
R
N
A
M
S
L
A
M
V
G
E
L
R
A
V
L
A
A
V
R
D
D
R
S
V
R
A
L
V
L
R
G
A
-
D
-
G
H
F
C
A
G
G
D
I
K
---
D
M
A
G
A
R
-
A
A
G
A
--------
E
A
Y
R
T
L
N
R
A
F
G
S
L
L
E
E
A
Q
A
A
P
Q
L
L
V
A
L
V
E
G
A
V
L
G
G
G
F
G
L
A
C
V
S
D
V
A
I
A
A
-
A
D
-
A
Q
F
G
L
P
E
T
S
L
G
I
L
P
-
A
Q
I
-
A
P
F
V
V
R
R
-
I
G
L
-
T
Q
A
R
R
L
A
L
T
A
A
R
F
D
G
R
E
A
L
R
L
G
L
V
H
F
C
E
A
D
A
D
A
L
E
------------------------------------------------------------------
Q
R
L
E
E
T
L
E
Q
L
R
R
C
A
P
N
A
N
A
A
T
K
A
L
L
L
A
S
-
E
S
G
E
L
G
--
A
-
L
L
-
D
D
A
A
R
Q
F
A
E
A
V
G
G
A
E
G
S
E
G
T
L
A
F
V
Q
K
--
R
K
P
V
W
A
Q
2
PsiBlast_PDB
78.96
55%
-110
- C3 -
4K3W
-
?
A:
[29-292]
-----
C
E
T
L
I
L
-
E
K
-
Q
G
P
T
L
V
I
T
I
N
R
-
P
D
V
R
N
A
M
S
L
Q
M
V
A
E
L
S
T
I
F
S
E
I
E
N
D
I
S
I
R
A
A
V
L
R
G
A
-
G
-
G
H
F
C
A
G
G
D
I
K
---
D
M
A
G
A
R
-
S
Q
K
A
GEGRD---
D
P
F
Y
K
L
N
R
A
F
G
Q
M
I
Q
Q
V
N
E
S
S
K
V
V
I
A
I
T
E
G
A
V
M
G
G
G
F
G
L
A
C
V
S
D
L
A
I
A
G
-
P
T
-
A
K
F
G
M
P
E
T
T
L
G
V
I
P
-
A
Q
I
-
A
P
F
V
V
E
R
-
I
G
L
-
T
Q
A
R
R
L
A
L
L
G
L
R
I
D
A
T
E
A
C
K
L
G
I
V
H
Q
V
A
E
S
E
E
Q
L
S
------------------------------------------------------------------
D
M
L
N
Q
A
L
E
R
V
R
L
C
A
P
D
A
T
A
E
T
K
A
L
L
H
R
V
-
G
H
E
A
M
A
--
G
-
L
L
-
D
D
A
A
E
K
F
A
A
A
I
R
G
P
E
G
A
E
G
T
M
A
F
M
Q
K
--
R
E
P
K
W
A
E
119
HHSearch
71.46
28%
-96
- C3 -
3BPT
2
HIBCH_HUMAN
A:
[5-331]
-----
A
E
E
V
L
L
-
G
K
-
K
G
C
T
G
V
I
T
L
N
R
-
P
K
F
L
N
A
L
T
L
N
M
I
R
Q
I
Y
P
Q
L
K
K
W
E
Q
D
P
E
T
F
L
I
I
I
K
G
A
-
G
G
K
A
F
C
A
G
G
D
I
R
---
V
I
S
E
A
E
-
K
A
K
Q
--------
K
I
A
P
V
F
F
R
E
E
Y
M
L
N
N
A
V
G
S
C
Q
K
P
Y
V
A
L
I
H
G
I
T
M
G
G
G
V
G
L
S
V
H
G
Q
F
R
V
A
T
-
E
K
-
C
L
F
A
M
P
E
T
A
I
G
L
F
P
D
V
G
G
-
G
Y
F
L
P
R
L
-
Q
G
K
--
L
G
Y
F
L
A
L
T
G
F
R
L
K
G
R
D
V
Y
R
A
G
I
A
T
H
F
V
D
S
-
E
K
L
A
M
L
E
E
D
L
L
A
LKSPS
K
E
N
I
A
S
V
L
E
N
Y
H
T
E
SKIDRDKSFILEEH
M
D
K
I
N
S
C
F
SANT
V
E
E
I
I
E
N
L
Q
Q
D
GS
S
F
A
L
E
Q
L
K
V
I
N
K
M
S
P
T
S
L
K
I
T
L
R
Q
L
M
E
G
-
S
S
K
T
L
Q
--
E
-
V
L
-
T
M
E
Y
R
L
S
Q
A
C
M
R
G
H
D
F
H
E
G
V
R
A
V
L
I
D
KD
Q
S
P
K
W
K
P
124
HHSearch
69.94
27%
-98
- C3 -
3PEA
3
?
A:
[4-260]
----
M
L
K
F
L
S
V
-
R
V
-
E
D
H
I
A
V
A
T
L
N
H
-
A
P
-
A
N
A
M
S
S
Q
V
M
H
D
V
T
E
L
I
D
Q
V
E
K
D
D
N
I
R
V
V
V
I
H
G
E
-
G
-
R
F
F
S
A
G
A
D
I
K
---
E
F
T
S
V
T
-
E
A
K
----------
Q
A
T
E
L
A
Q
L
G
Q
V
T
F
E
R
V
E
K
C
S
K
P
V
I
A
A
I
H
G
A
A
L
G
G
G
L
E
F
A
M
S
C
H
M
R
F
A
T
-
E
S
-
A
K
L
G
L
P
E
L
T
L
G
L
I
P
G
F
A
G
-
T
Q
R
L
P
R
Y
-
V
G
K
-
A
K
A
C
E
M
M
L
T
S
T
P
I
T
G
A
E
A
L
K
W
G
L
V
N
G
V
F
A
E
-
E
T
F
L
------------------------------------------------------------------
D
D
T
L
K
V
A
K
Q
I
A
G
K
S
P
A
T
A
R
A
V
L
E
L
L
Q
T
T
-
K
S
S
H
Y
Y
--
E
-
G
V
-
Q
R
E
A
Q
I
F
G
E
V
F
T
S
E
D
G
R
E
G
V
A
A
F
L
E
K
--
R
K
P
S
F
S
G
117
HHSearch
67.48
26%
-95
- C3 -
3QK8
7
?
A:
[9-266]
--
Y
Q
D
F
P
S
L
R
F
-
E
P
G
E
H
G
V
L
N
L
V
L
D
S
-
P
G
-
L
N
S
V
G
P
Q
M
H
R
D
L
A
D
V
W
P
V
I
D
R
D
P
D
V
R
V
V
L
V
R
G
E
-
G
-
K
A
F
S
S
G
G
S
F
E
---
L
I
D
E
T
I
-
G
D
Y
---------
E
G
R
I
R
I
M
R
E
A
R
D
L
V
L
N
L
V
N
L
D
K
P
V
V
S
A
I
R
G
P
A
V
G
A
G
L
V
V
A
L
L
A
D
I
S
V
A
S
-
A
T
-
A
K
I
I
D
G
H
T
K
L
G
V
A
A
G
D
H
A
-
A
I
C
W
P
L
L
-
V
G
M
-
A
K
A
K
Y
Y
L
L
T
C
E
T
L
S
G
E
E
A
E
R
I
G
L
V
S
T
C
V
D
D
-
D
E
V
L
------------------------------------------------------------------
P
T
A
T
R
L
A
E
N
L
A
Q
G
A
Q
N
A
I
R
W
T
K
R
S
L
N
H
W
-
Y
R
M
F
-
G
--
P
-
T
F
-
E
T
S
L
G
L
E
F
L
G
F
T
G
P
D
V
Q
E
G
L
A
A
H
R
Q
K
--
R
P
A
R
F
--
123
HHSearch
66.50
30%
-91
- C3 -
3KQF
1
?
A:
[7-264]
-----
L
Q
N
I
S
V
-
D
Y
A
T
P
H
V
V
K
I
S
L
N
R
-
E
R
Q
A
N
S
L
S
L
A
L
L
E
E
L
Q
N
I
L
T
Q
I
N
E
E
A
N
T
R
V
V
I
L
T
G
A
-
G
E
K
A
F
C
A
G
A
D
L
K
---
E
R
A
G
M
N
-
E
E
-----------
Q
V
R
H
A
V
S
M
I
R
T
T
M
E
M
V
E
Q
L
P
Q
P
V
I
A
A
I
N
G
I
A
L
G
G
G
T
E
L
S
L
A
C
D
F
R
I
A
A
-
E
S
-
A
S
L
G
L
T
E
T
T
L
A
I
I
P
G
A
G
G
-
T
Q
R
L
P
R
L
-
I
G
V
-
G
R
A
K
E
L
I
Y
T
G
R
R
I
S
A
Q
E
A
K
E
Y
G
L
V
E
F
V
V
P
V
-
H
L
L
E
------------------------------------------------------------------
E
K
A
I
E
I
A
E
K
I
A
S
N
G
P
I
A
V
R
L
A
K
E
A
I
S
N
G
-
I
Q
V
D
L
H
--
T
-
G
L
-
Q
M
E
K
Q
A
Y
E
G
V
I
H
T
K
D
R
L
E
G
L
Q
A
F
K
E
K
--
R
T
P
M
Y
K
G
114
HHSearch
65.42
33%
-103
- C3 -
3I47
-
?
A:
[2-260]
----
S
L
S
D
L
L
Y
-
E
I
-
Q
D
K
V
G
L
L
T
M
N
R
-
I
S
K
H
N
A
F
D
N
Q
L
L
T
E
M
R
I
R
L
D
S
A
I
N
D
T
N
V
R
V
I
V
L
K
A
N
-
G
-
K
H
F
S
A
G
A
D
L
T
---
W
M
Q
S
M
A
-
N
F
T
E
--------
E
E
N
L
E
D
S
L
V
L
G
N
L
M
Y
S
I
S
Q
S
P
K
P
T
I
A
M
V
Q
G
A
A
F
G
G
G
A
G
L
A
A
A
C
D
I
A
I
A
S
-
T
S
-
A
R
F
C
F
S
E
V
K
L
G
L
I
P
-
A
V
I
-
S
P
Y
V
V
R
A
-
I
G
E
-
R
A
A
K
M
L
F
M
S
A
E
V
F
D
A
T
R
A
Y
S
L
N
L
V
Q
H
C
V
P
D
-
D
T
L
L
------------------------------------------------------------------
E
F
T
L
K
Y
A
S
Q
I
S
N
N
A
P
E
A
V
K
N
S
K
Q
L
A
Q
Y
V
-
A
N
K
K
I
D
--
E
-
E
L
V
R
Y
T
A
S
L
I
A
H
K
R
V
S
D
E
G
Q
E
G
L
K
A
F
L
N
K
--
E
I
P
N
W
N
-
113
HHSearch
64.32
19%
-104
- C3 -
2GTR
-
CDYL1_HUMAN
A:
[3-260]
----
R
Y
R
D
I
V
V
-
R
K
-
Q
D
G
F
T
H
I
L
L
S
T
K
S
S
E
N
N
S
L
N
P
E
V
M
R
E
V
Q
S
A
L
S
T
A
A
A
D
D
-
S
K
L
V
L
L
S
A
V
-
G
-
S
V
F
C
C
G
L
D
F
I
---
Y
F
I
R
R
L
-
T
D
D
R
K
-------
R
E
S
T
K
M
A
E
A
I
R
N
F
V
N
T
F
I
Q
F
K
K
P
I
I
V
A
V
N
G
P
A
I
G
L
G
A
S
I
L
P
L
C
D
V
V
W
A
N
-
E
K
-
A
W
F
Q
T
P
Y
T
T
F
G
Q
S
P
D
G
C
S
-
T
V
M
F
P
K
I
-
M
G
G
-
A
S
A
N
E
M
L
L
S
G
R
K
L
T
A
Q
E
A
C
G
K
G
L
V
S
Q
V
F
W
P
-
G
T
F
T
------------------------------------------------------------------
Q
E
V
M
V
R
I
K
E
L
A
S
C
N
P
V
V
L
E
E
S
K
A
L
V
R
C
N
-
M
K
M
E
L
E
--
Q
-
A
N
-
E
R
E
C
E
V
L
K
K
I
W
G
S
A
Q
G
M
D
S
M
L
K
Y
L
Q
R
--
K
I
D
E
---
5
PsiBlast_PDB
64.29
33%
-98
- C3 -
3I47
-
?
A:
[6-260]
--------
L
L
Y
-
E
I
-
Q
D
K
V
G
L
L
T
M
N
R
-
I
S
K
H
N
A
F
D
N
Q
L
L
T
E
M
R
I
R
L
D
S
A
I
N
D
T
N
V
R
V
I
V
L
K
A
N
-
G
-
K
H
F
S
A
G
A
D
L
T
---
W
M
Q
S
M
A
-
N
F
T
E
--------
E
E
N
L
E
D
S
L
V
L
G
N
L
M
Y
S
I
S
Q
S
P
K
P
T
I
A
M
V
Q
G
A
A
F
G
G
G
A
G
L
A
A
A
C
D
I
A
I
A
S
-
T
S
-
A
R
F
C
F
S
E
V
K
L
G
L
I
P
-
A
V
I
-
S
P
Y
V
V
R
A
-
I
G
E
-
R
A
A
K
M
L
F
M
S
A
E
V
F
D
A
T
R
A
Y
S
L
N
L
V
Q
H
C
V
P
D
D
T
L
L
E
------------------------------------------------------------------
F
T
L
K
Y
A
-
S
Q
I
S
N
N
A
P
E
A
V
K
N
S
K
Q
L
A
Q
Y
V
-
A
N
K
K
I
D
E
-
E
-
L
V
-
R
Y
T
A
S
L
I
A
H
K
R
V
S
D
E
G
Q
E
G
L
K
A
F
L
N
K
--
E
I
P
N
W
N
-
4
PsiBlast_PDB
64.25
33%
-102
- C3 -
4KPK
1
?
A:
[48-292]
-----------------
G
V
A
Q
M
V
L
D
R
-
S
D
K
H
N
A
F
D
E
V
M
I
S
E
M
I
Q
V
L
E
H
F
K
R
N
E
Q
C
Q
I
L
L
L
K
A
N
-
G
-
K
N
F
S
A
G
A
D
L
N
---
W
M
R
K
Q
A
-
K
M
D
F
--------
E
Q
N
L
A
D
A
N
E
L
A
R
L
M
S
M
L
D
K
F
P
K
P
T
I
T
L
V
Q
G
A
A
F
G
G
A
L
G
L
I
C
C
S
D
I
A
I
A
N
-
E
R
-
A
S
F
C
L
S
E
V
K
L
G
L
I
P
-
A
V
I
-
S
P
Y
V
T
R
A
-
M
G
Q
-
R
A
A
R
R
Y
M
L
T
A
E
R
F
D
A
Q
K
A
L
E
L
Q
I
I
H
D
I
N
D
D
L
D
A
A
A
------------------------------------------------------------------
Q
P
F
---
I
D
A
L
L
S
N
S
P
Q
G
M
A
W
V
K
C
L
L
S
S
L
-
E
D
G
V
I
D
--
Q
N
T
L
-
D
H
T
S
E
R
I
A
R
I
R
V
S
E
E
G
Q
E
G
L
N
A
F
F
E
K
--
R
S
P
Q
W
--
121
HHSearch
62.50
29%
-98
- C3 -
3FDU
2
?
A:
[2-249]
---
S
L
H
P
H
L
N
A
-
N
L
-
E
G
G
V
L
T
L
A
I
N
R
-
P
E
A
K
N
A
L
Y
G
E
L
Y
L
W
I
A
K
A
L
D
E
A
D
Q
N
K
D
V
R
V
V
V
L
R
G
A
-
E
-
H
D
F
T
A
G
N
D
M
K
---
D
F
M
G
F
V
-
Q
N
P
N
---------
A
G
P
A
G
Q
V
P
P
F
V
L
L
K
S
A
A
R
L
S
K
P
L
I
I
A
V
K
G
V
A
I
G
I
G
V
T
I
L
L
Q
A
D
L
V
F
A
D
-
N
T
-
A
L
F
Q
I
P
F
V
S
L
G
L
S
P
E
G
G
A
-
S
Q
L
L
V
K
Q
-
A
G
Y
-
H
K
A
A
E
L
L
F
T
A
K
K
F
N
A
E
T
A
L
Q
A
G
L
V
N
E
I
V
E
D
---
A
Y
------------------------------------------------------------------
A
T
A
Q
A
T
A
Q
H
L
T
A
L
P
L
A
S
L
K
Q
T
K
A
L
M
K
H
D
-
L
D
-
Q
I
I
--
E
-
C
I
-
D
H
E
A
E
I
F
M
Q
R
V
Q
S
P
E
M
L
E
A
V
Q
A
F
M
-----------
106
HHSearch
62.48
28%
-93
- C3 -
2EJ5
-
?
A:
[4-258]
-----
Y
E
T
I
R
Y
-
E
V
-
K
G
Q
V
A
W
L
T
L
N
R
-
P
D
Q
L
N
A
F
T
E
Q
M
N
A
E
V
T
K
A
L
K
Q
A
G
A
D
P
N
V
R
C
V
V
I
T
G
A
-
G
-
R
A
F
C
A
G
E
D
L
-----------
D
H
------------
G
D
V
L
R
S
R
Y
A
P
M
M
K
A
L
H
H
L
E
K
P
V
V
A
A
V
N
G
A
A
A
G
A
G
M
S
L
A
L
A
C
D
F
R
L
L
S
-
E
K
-
A
S
F
A
P
A
F
I
H
V
G
L
V
P
D
A
G
H
-
L
Y
Y
L
P
R
L
-
V
G
R
-
A
K
A
L
E
L
A
V
L
G
E
K
V
T
A
E
E
A
A
A
L
G
L
A
T
K
V
I
P
L
-
S
D
W
E
------------------------------------------------------------------
E
E
V
K
Q
F
A
E
R
L
S
A
M
P
T
K
A
I
G
L
I
K
R
L
L
R
E
S
-
E
E
T
T
F
D
--
R
-
Y
L
-
E
R
E
A
E
C
Q
R
I
A
G
L
T
S
D
H
R
E
G
V
K
A
F
F
E
K
--
R
K
P
L
F
Q
G
122
HHSearch
62.15
23%
-92
- C3 -
3H0U
3
?
A:
[3-262]
-
L
T
A
S
Y
E
T
I
K
A
-
R
L
-
D
G
T
V
L
S
A
T
F
N
A
-
P
P
-
M
N
L
I
G
P
E
V
V
R
D
L
V
A
L
L
E
E
L
A
H
P
T
A
P
R
V
V
I
F
D
S
A
-
D
A
D
F
F
F
P
H
V
D
M
T
---
K
V
P
E
Y
T
-
A
E
A
A
--------
K
A
G
G
P
G
D
A
S
L
G
M
L
F
R
K
L
S
Q
L
P
A
V
T
I
A
K
L
R
G
R
A
R
G
A
G
S
E
F
L
L
A
C
D
M
R
F
A
S
R
E
N
-
A
I
L
G
Q
P
E
V
G
I
G
A
P
P
G
A
G
A
-
I
Q
H
L
T
R
L
-
L
G
R
-
G
R
A
L
E
A
V
L
T
S
S
D
F
D
A
D
L
A
E
R
Y
G
W
V
N
R
A
V
P
D
-
A
E
L
D
------------------------------------------------------------------
E
F
V
A
G
I
A
A
R
M
S
G
F
P
R
D
A
L
I
A
A
K
S
A
I
N
A
I
-
S
L
-
P
A
P
--
A
-
E
V
-
R
A
D
A
A
L
F
Q
Q
L
V
R
G
E
K
V
Q
Q
R
T
A
E
L
F
K
Q
--
G
F
Q
T
---
108
HHSearch
62.04
25%
-93
- C3 -
1DCI
7
ECH1_RAT
A:
[3-271]
------
E
S
I
Q
V
T
S
A
-
Q
K
H
V
L
H
V
Q
L
N
R
-
P
E
K
R
N
A
M
N
R
A
F
W
R
E
L
V
E
C
F
Q
K
I
S
K
D
S
D
C
R
A
V
V
V
S
G
A
-
G
-
K
M
F
T
S
G
I
D
L
M
---
D
M
A
S
D
I
-
L
Q
P
P
G
DD
V
A
R
I
A
W
Y
L
R
D
L
I
S
R
Y
Q
K
T
F
T
V
I
E
K
C
P
K
P
V
I
A
A
I
H
G
G
C
I
G
G
G
V
D
L
I
S
A
C
D
I
R
Y
C
T
-
Q
D
-
A
F
F
Q
V
K
E
V
D
V
G
L
A
A
D
V
G
T
-
L
Q
R
L
P
K
V
-
I
G
N
R
S
L
V
N
E
L
T
F
T
A
R
K
M
M
A
D
E
A
L
D
S
G
L
V
S
R
V
F
P
D
K
D
V
M
L
------------------------------------------------------------------
N
A
A
F
A
L
A
A
D
I
S
S
K
S
P
V
A
V
Q
G
S
K
I
N
L
I
Y
S
-
R
D
H
S
V
D
--
E
-
S
L
-
D
Y
M
A
T
W
N
M
S
M
L
Q
T
Q
D
I
I
K
S
V
Q
A
A
M
E
K
--
K
D
S
K
S
I
T
111
HHSearch
61.95
24%
-91
- C3 -
2PPY
3
?
A:
[6-264]
---
T
K
K
Q
Y
L
T
V
-
F
K
-
E
D
G
I
A
E
I
H
L
H
I
-
N
K
-
S
N
S
Y
D
L
E
F
Y
K
E
F
N
A
A
I
D
D
I
R
F
D
P
D
I
K
V
V
I
V
M
S
D
V
P
-
K
F
F
S
A
G
A
D
I
N
---
F
L
R
S
A
D
-
P
R
-----------
F
K
T
Q
F
C
L
F
C
N
E
T
L
D
K
I
A
R
S
P
Q
V
Y
I
A
C
L
E
G
H
T
V
G
G
G
L
E
M
A
L
A
C
D
L
R
F
M
G
-
D
E
A
G
K
I
G
L
P
E
V
S
L
G
V
L
A
G
T
G
G
-
T
Q
R
L
A
R
L
-
I
G
Y
-
S
R
A
L
D
M
N
I
T
G
E
T
I
T
P
Q
E
A
L
E
I
G
L
V
N
R
V
F
P
Q
-
A
E
T
R
------------------------------------------------------------------
E
R
T
R
E
Y
A
R
K
L
A
N
S
A
T
Y
A
V
S
N
I
K
L
A
I
M
N
G
-
K
E
M
P
L
N
--
V
-
A
I
-
R
Y
E
G
E
L
Q
N
L
L
F
R
S
E
D
A
K
E
G
L
S
A
F
L
E
K
--
R
Q
P
N
W
K
G
62
PsiBlast_CBE
61.81
32%
-91
- C3 -
4ELX
6
MENB_ECOLI
B:
[32-280]
----------------
D
G
I
A
K
I
T
I
N
R
-
P
Q
V
R
N
A
F
R
P
L
T
V
K
E
M
I
Q
A
L
A
D
A
R
Y
D
D
N
I
G
V
I
I
L
T
G
A
G
D
-
K
A
F
C
S
G
G
D
Q
K
V------------
V
--------
H
H
L
N
V
L
D
-----
F
Q
R
Q
I
R
T
C
P
K
P
V
V
A
M
V
A
G
Y
S
I
G
G
G
H
V
L
H
M
M
C
D
L
T
I
A
A
-
D
N
-
A
I
F
G
Q
T
G
P
K
V
G
S
F
D
-
G
G
W
G
A
S
Y
M
A
R
I
-
V
G
Q
-
K
K
A
R
E
I
W
F
L
C
R
Q
Y
D
A
K
Q
A
L
D
M
G
L
V
N
T
V
V
P
L
A
D
-
L
E
------------------------------------------------------------------
K
E
T
V
R
W
C
R
E
M
L
Q
N
S
P
M
A
L
R
C
L
K
A
A
L
N
A
D
-
C
D
G
Q
A
G
L
Q
E
-
L
A
-
G
N
A
T
M
L
F
Y
M
T
---
E
E
G
Q
E
G
R
N
A
F
N
Q
K
--
R
Q
P
D
F
S
K
12
PsiBlast_PDB
61.81
32%
-93
- C3 -
4JCS
-
?
A:
[24-277]
------
D
T
L
D
F
-
E
V
-
V
N
N
V
G
W
I
R
M
N
R
-
A
A
K
H
N
P
F
D
A
E
L
R
A
D
L
M
T
V
L
E
R
V
R
D
D
A
D
I
R
V
L
V
L
T
S
H
-
P
-
G
S
F
C
A
--
N
L
H
---
V
L
R
D
N
L
-
D
S
G
P
--------
A
Y
W
Q
Q
R
I
K
T
G
L
R
F
I
H
D
M
L
N
L
G
R
P
V
I
A
A
V
D
G
P
A
F
G
A
G
F
A
L
S
L
T
A
D
I
V
L
A
S
-
P
R
-
A
R
F
S
M
A
Y
L
R
L
G
L
V
P
-
D
L
G
-
A
L
Y
L
L
P
R
A
V
G
L
-
Q
R
A
K
E
L
M
F
S
T
R
E
L
D
A
E
E
A
H
R
L
G
L
V
M
E
V
H
-
E
S
E
A
L
E
------------------------------------------------------------------
Q
R
A
R
E
I
A
E
S
L
V
Q
A
A
P
T
A
L
A
L
T
K
A
A
L
N
V
S
L
D
S
D
E
Q
T
--
M
-
F
S
-
L
E
A
A
S
Q
-
A
A
A
F
S
T
K
E
P
R
A
A
I
E
A
L
L
S
K
--
Q
P
P
----
43
PsiBlast_CBE
61.32
32%
-88
- C3 -
3T88
7
MENB_ECOLI
E:
[36-284]
----------------
D
G
I
A
K
I
T
I
N
R
-
P
Q
V
R
N
A
F
R
P
L
T
V
K
E
M
I
Q
A
L
A
D
A
R
Y
D
D
N
I
G
V
I
I
L
T
G
A
G
D
-
K
A
F
C
S
G
G
D
Q
K
VRG
D
Y
G
G
Y
K
D
D
S
G
V
--------
H
H
L
N
V
L
D
-----
F
Q
R
Q
I
R
T
C
P
K
P
V
V
A
M
V
A
G
Y
S
I
G
G
G
H
V
L
H
M
M
C
D
L
T
I
A
A
-
D
N
-
A
I
F
G
Q
T
G
P
K
V
G
S
F
D
-
G
G
W
G
A
S
Y
M
A
R
I
-
V
G
Q
-
K
K
A
R
E
I
W
F
L
C
R
Q
Y
D
A
K
Q
A
L
D
M
G
L
V
N
T
V
V
P
L
A
D
-
L
E
------------------------------------------------------------------
K
E
T
V
R
W
C
R
E
M
L
Q
N
S
P
M
A
L
R
C
L
K
A
A
L
N
A
D
-
C
D
G
Q
A
G
LQ
E
-
L
A
-
G
N
A
T
M
L
F
Y
M
T
---
E
E
G
Q
E
G
R
N
A
F
N
Q
K
--
R
Q
P
D
F
S
K