@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2951: (2016-02-12 )
MAILVIAEHNNAALAAATLNTVAAAKAIGGDIHVLVAGQNVAAVAEAAAKVEGVSKVLVADNAAYAHQLPENVAPLIAELGKNYSHVLAPATTNGKNFLPRVAALLDVDQISEIVEVVSPDTFKRPIYAGNAIATVQSSAAVKVITVRTTGFDAVAAEGGSAAVEQVSGPADAGKSAFVGEELAKSDRPELTAAKIVVSGGRGMQNGDNFKILYALADKLGAAVGASRAAVDAGFVPNDMQVGQTGKIVAPQLYIAVGISGAIQHLAGMKDSKVIVAINKDEEAPIFQVADYGLVADLFDAVPELEKAV
Atome Classification :
(21 SA)
.........10...-.-....20.......----.30......--..40..-..-....50........60.......---.70........80.-.--.--.--.....90........100.......110.--......120-.----........130.......140.-..-------------.....150...---....-160.......170.....---..180-.......190.......200.......210.......220.......230.......240.......-250.......260.......270.......280.......290.......300.......-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
I
L
V
I
A
EHNN
A
A
L
-
A
-
A
A
T
L
N
T
V
A
A
A
K
AI----GG
D
I
H
V
L
V
A--GQ
N
V
A
A
-
V
A
-
E
A
A
A
K
V
EG
V
S
K
V
L
VADN
A
A
Y
A
H
Q---L
P
E
N
V
A
P
L
I
A
E
L
-G-K--N--Y--
S
H
V
LAPATTNG
K
N
F
L
P
R
V
A
A
L
L
D
V
D
Q
I
S
E
--
I
V
E
VVSP---D----TFKRPIYAGN
A
I
A
T
VQSS
A
-
A
V
-
K
V
-------------
I
T
V
RTTGF
D
A
V---AAEG-G
S
A
A
V
E
QVSGPADAGKSA---F
V
G
E
E
-
L
A
KSDRPE
L
T
A
A
K
I
V
V
SGGRGMQNGD
N
F
K
I
L
Y
A
L
A
D
K
L
G
A
AVGASRAAVDAGFVPNDMQVGQTG
K
I
V-A
P
Q
L
Y
I
A
VG
I
S
G
A
I
Q
H
L
AGMKD
S
K
V
I
V
A
INKDEEA
P
I
F
Q
VA
D
Y
G
L
V
A
D
L
F
D
A
V
P
E
L
E
KAV-
4
PsiBlast_PDB
98.66
63%
-122
- C3 -
2A1U
1
ETFA_HUMAN
A:
[21-326]
-
S
T
L
V
I
A
E
H
A
N
D
S
L
-
A
-
P
I
T
L
N
T
I
T
A
A
T
R
L
----
G
G
E
V
S
C
L
V
A
--
G
T
K
C
D
K
-
V
A
-
Q
D
L
C
K
V
A
G
I
A
K
V
L
V
A
Q
H
D
V
Y
K
G
L
---
L
P
E
E
L
T
P
L
I
L
A
T
-
Q
-
K
Q
F
N
--
Y
--
T
H
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
--
I
I
A
I
K
S
P
---
D
----
T
F
V
R
T
I
Y
A
G
N
A
L
C
T
V
K
C
D
E
-
K
V
-
K
V
-------------
F
S
V
R
G
T
S
F
D
A
A
---
A
T
S
G
-
G
S
A
S
S
E
K
A
S
S
T
S
P
V
E
I
S
E
---
W
L
D
Q
K
-
L
T
K
S
D
R
P
E
L
T
G
A
K
V
V
V
S
G
G
R
G
L
K
S
G
E
N
F
K
L
L
Y
D
L
A
D
Q
L
H
A
A
V
G
A
S
R
A
A
V
D
A
G
F
V
P
N
D
M
Q
V
G
Q
T
G
K
I
V
-
A
P
E
L
Y
I
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
T
I
V
A
I
N
K
D
P
E
A
P
I
F
Q
V
A
D
Y
G
I
V
A
D
L
F
K
V
V
P
E
M
-----
47
Fugue
97.50
62%
-119
- C3 -
1EFV
1
ETFA_HUMAN
A:
[2-313]
Q
S
T
L
V
I
A
E
H
A
N
D
S
L
A--
P
I
T
L
N
T
I
T
A
A
T
R
L
----
G
G
E
V
S
C
L
V
A
--
G
T
K
C
D
K
-
V
A
-
Q
D
L
C
K
V
A
G
I
A
K
V
L
V
A
Q
H
D
V
Y
K
G
L
---
L
P
E
E
L
T
P
L
I
L
A
T
-
Q
-
K
--
Q
FN
Y
--
T
H
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
--
I
I
A
I
K
S
P
---
D
----
T
F
V
R
T
I
Y
A
G
N
A
L
C
T
V
K
C
D
E
-
K
V
-
K
V
-------------
F
S
V
R
G
T
S
F
D
A
A
---
A
T
S
G
-
G
S
A
S
S
E
K
A
S
S
T
S
P
V
E
I
S
E
---
W
L
D
Q
K
-
L
T
K
S
D
R
P
E
L
T
G
A
K
V
V
V
S
G
G
R
G
L
K
S
G
E
N
F
K
L
L
Y
D
L
A
D
Q
L
H
A
A
V
G
A
S
R
A
A
V
D
A
G
F
V
P
N
D
M
Q
V
G
Q
T
G
K
I
V
-
A
P
E
L
Y
I
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
T
I
V
A
I
N
K
D
P
E
A
P
I
F
Q
V
A
D
Y
G
I
V
A
D
L
F
K
V
V
P
E
M
T
E
I
L
K
1
PsiBlast_PDB
97.20
63%
-120
- C3 -
1EFV
1
ETFA_HUMAN
A:
[3-308]
-
S
T
L
V
I
A
E
H
A
N
D
S
L
-
A
-
P
I
T
L
N
T
I
T
A
A
T
R
L
----
G
G
E
V
S
C
L
V
A
--
G
T
K
C
D
K
-
V
A
-
Q
D
L
C
K
V
A
G
I
A
K
V
L
V
A
Q
H
D
V
Y
K
G
L
---
L
P
E
E
L
T
P
L
I
L
A
T
-
Q
-
K
Q
F
N
--
Y
--
T
H
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
--
I
I
A
I
K
S
P
---
D
----
T
F
V
R
T
I
Y
A
G
N
A
L
C
T
V
K
C
D
E
-
K
V
-
K
V
-------------
F
S
V
R
G
T
S
F
D
A
A
---
A
T
S
G
-
G
S
A
S
S
E
K
A
S
S
T
S
P
V
E
I
S
E
---
W
L
D
Q
K
-
L
T
K
S
D
R
P
E
L
T
G
A
K
V
V
V
S
G
G
R
G
L
K
S
G
E
N
F
K
L
L
Y
D
L
A
D
Q
L
H
A
A
V
G
A
S
R
A
A
V
D
A
G
F
V
P
N
D
M
Q
V
G
Q
T
G
K
I
V
-
A
P
E
L
Y
I
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
T
I
V
A
I
N
K
D
P
E
A
P
I
F
Q
V
A
D
Y
G
I
V
A
D
L
F
K
V
V
P
E
M
-----
25
HHSearch
95.85
61%
-112
- C3 -
1EFV
1
ETFA_HUMAN
A:
[2-312]
Q
S
T
L
V
I
A
E
H
A
N
D
S
L
-
A
-
P
I
T
L
N
T
I
T
A
A
T
R
L
----
G
G
E
V
S
C
L
V
A
--
G
T
K
C
D
K
V
A
Q
-
D
L
C
K
V
-
A
G
I
A
K
V
L
V
A
Q
H
D
V
Y
K
G
L
---
L
P
E
E
L
T
P
L
I
L
A
T
Q
K
Q
F
--
N
--
Y
--
T
H
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
--
I
I
A
I
K
S
P
---
D
----
T
F
V
R
T
I
Y
A
G
N
A
L
C
T
V
K
C
D
E
-
K
V
-
K
V
-------------
F
S
V
R
G
T
S
F
D
A
A
---
A
T
S
G
-
G
S
A
S
S
E
K
A
S
S
T
S
P
V
E
I
S
E
---
W
L
D
Q
K
-
L
T
K
S
D
R
P
E
L
T
G
A
K
V
V
V
S
G
G
R
G
L
K
S
G
E
N
F
K
L
L
Y
D
L
A
D
Q
L
H
A
A
V
G
A
S
R
A
A
V
D
A
G
F
V
P
N
D
M
Q
V
G
Q
T
G
K
I
V
-
A
P
E
L
Y
I
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
T
I
V
A
I
N
K
D
P
E
A
P
I
F
Q
V
A
D
Y
G
I
V
A
D
L
F
K
V
V
P
E
M
T
E
I
L
-
3
PsiBlast_PDB
95.77
63%
-128
- C3 -
2A1T
1
ETFA_HUMAN
R:
[21-326]
-
S
T
L
V
I
A
E
H
A
N
D
S
L
-
A
-
P
I
T
L
N
T
I
T
A
A
T
R
L
----
G
G
E
V
S
C
L
V
A
--
G
T
K
C
D
K
-
V
A
-
Q
D
L
C
K
V
A
G
I
A
K
V
L
V
A
Q
H
D
V
Y
K
G
L
---
L
P
E
E
L
T
P
L
I
L
A
T
-
Q
-
K
QF
N
--
Y
--
T
H
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
--
I
I
A
I
K
S
P
---
D
----
T
F
V
R
T
I
Y
A
G
N
A
L
C
T
V
K
C
D
E
-
K
V
-
K
V
-------------
F
S
V
R
G
T
S
F
D
A
A
---
A
T
S
G
-
G
S
A
S
S
E
K
A
S
S
T
S
P
V
E
I
S
E
---
W
L
D
Q
K
-
L
T
---
R
P
E
L
T
G
A
K
V
V
V
S
G
G
R
G
L
K
S
G
E
N
F
K
L
L
Y
D
L
A
D
Q
L
H
A
A
V
G
A
S
R
A
A
V
D
A
G
F
V
P
N
D
M
Q
V
G
Q
T
G
K
I
V
-
A
P
E
L
Y
I
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
T
I
V
A
I
N
K
D
P
E
A
P
I
F
Q
V
A
D
Y
G
I
V
A
D
L
F
K
V
V
P
E
M
-----
26
HHSearch
89.55
63%
-108
- C3 -
1EFP
1
ETFA_PARDE
A:
[1-307]
-
A
V
L
L
L
G
E
V
T
N
G
A
L
-
N
R
D
A
T
A
K
A
V
A
A
V
K
A
L
----
G
-
D
V
T
V
L
C
A
--
G
A
S
A
K
A
-
A
A
E
E
A
A
K
I
-
A
G
V
A
K
V
L
V
A
E
D
A
L
Y
G
H
R
---
L
A
E
P
T
A
A
L
I
V
G
L
A
G
----
D
--
Y
--
S
H
I
A
A
P
A
T
T
D
A
K
N
V
M
P
R
V
A
A
L
L
D
V
M
V
L
S
D
--
V
S
A
I
L
D
A
---
D
----
T
F
E
R
P
I
Y
A
G
N
A
I
Q
V
V
K
S
K
D
-
A
K
-
K
V
-------------
F
T
I
R
T
A
S
F
D
A
A
---
G
E
G
G
--
T
A
P
V
T
E
T
A
A
A
A
D
P
G
L
S
S
---
W
V
A
D
E
-
V
A
E
S
D
R
P
E
L
T
S
A
R
R
V
V
S
G
G
R
G
L
G
S
K
E
S
F
A
I
I
E
E
L
A
D
K
L
G
A
A
V
G
A
S
R
A
A
V
D
S
G
Y
A
P
N
D
W
Q
V
G
Q
T
G
K
V
V
-
A
P
E
L
Y
V
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
V
I
V
A
I
N
K
D
E
E
A
P
I
F
Q
I
A
D
Y
G
L
V
G
D
L
F
S
V
V
P
E
L
T
G
K
L
-
5
PsiBlast_PDB
88.28
61%
-111
- C3 -
1EFP
1
ETFA_PARDE
A:
[1-303]
-
A
V
L
L
L
G
E
V
T
N
G
A
L
-
N
-
R
D
A
T
A
K
A
V
A
A
V
K
A
----
L
G
D
V
T
V
L
C
A
--
G
A
S
A
K
A
-
A
A
-
E
E
A
A
K
I
A
G
V
A
K
V
L
V
A
E
D
A
L
Y
G
H
R
---
L
A
E
P
T
A
A
L
I
V
G
L
-
A
-
G
--
D
--
Y
--
S
H
I
A
A
P
A
T
T
D
A
K
N
V
M
P
R
V
A
A
L
L
D
V
M
V
L
S
D
--
V
S
A
I
L
D
A
---
D
----
T
F
E
R
P
I
Y
A
G
N
A
I
Q
V
V
K
S
K
D
-
A
K
-
K
V
-------------
F
T
I
R
T
A
S
F
D
A
----
A
G
E
G
-
G
T
A
P
V
T
E
T
A
A
A
A
D
P
G
L
S
S
---
W
V
A
D
E
-
V
A
E
S
D
R
P
E
L
T
S
A
R
R
V
V
S
G
G
R
G
L
G
S
K
E
S
F
A
I
I
E
E
L
A
D
K
L
G
A
A
V
G
A
S
R
A
A
V
D
S
G
Y
A
P
N
D
W
Q
V
G
Q
T
G
K
V
V
-
A
P
E
L
Y
V
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
V
I
V
A
I
N
K
D
E
E
A
P
I
F
Q
I
A
D
Y
G
L
V
G
D
L
F
S
V
V
P
E
L
-----
21
PsiBlast_CBE
87.86
61%
-110
- C3 -
1EFP
1
ETFA_PARDE
C:
[1-303]
-
A
V
L
L
L
G
E
V
T
N
G
A
L
-
N
-
R
D
A
T
A
K
A
V
A
A
V
K
A
----
L
G
D
V
T
V
L
C
A
--
G
A
S
A
K
A
-
A
A
-
E
E
A
A
K
I
A
G
V
A
K
V
L
V
A
E
D
A
L
Y
G
H
R
---
L
A
E
P
T
A
A
L
I
V
G
L
-
A
-
G
--
D
--
Y
--
S
H
I
A
A
P
A
T
T
D
A
K
N
V
M
P
R
V
A
A
L
L
D
V
M
V
L
S
D
--
V
S
A
I
L
D
A
---
D
----
T
F
E
R
P
I
Y
A
G
N
A
I
Q
V
V
K
S
K
D
-
A
K
-
K
V
-------------
F
T
I
R
T
A
S
F
D
A
----
A
G
E
G
-
G
T
A
P
V
T
E
T
A
A
A
A
D
P
G
L
S
S
---
W
V
A
D
E
-
V
A
E
S
D
R
P
E
L
T
S
A
R
R
V
V
S
G
G
R
G
L
G
S
K
E
S
F
A
I
I
E
E
L
A
D
K
L
G
A
A
V
G
A
S
R
A
A
V
D
S
G
Y
A
P
N
D
W
Q
V
G
Q
T
G
K
V
V
-
A
P
E
L
Y
V
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
V
I
V
A
I
N
K
D
E
E
A
P
I
F
Q
I
A
D
Y
G
L
V
G
D
L
F
S
V
V
P
E
L
-----
12
PsiBlast_PDB
75.84
32%
-111
- C3 -
3CLU
1
ETFA_METME
D:
[4-316]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
G
L
KK--
S
G
E
D
K
V
V
V
A
VI
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
-
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
D
F
D
PDV
F
E
A
S
V
S
A
L
I
A
---
A
-
H
--
N
--
P
--
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
VY
I
V
E
------------------
Y
Q
G
D
E
L
V
A
T
R
G
G
Y
-
N
Q
-
K
V
NVEVDFPGKSTVV
L
T
I
R
P
S
V
F
K
P
L
-----
E
G
A
G
S
P
V
V
S
N
V
D
A
P
S
V
Q
S
R
S
Q
NKD
Y
V
--
E
-
V
G
G
G
N
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
K
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
----
14
PsiBlast_PDB
75.73
32%
-112
- C3 -
3CLS
1
ETFA_METME
D:
[4-316]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
G
L
KK--
S
G
E
D
K
V
V
V
A
VI
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
-
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
D
F
D
PDV
F
E
A
S
V
S
A
L
I
A
---
A
-
H
--
N
--
P
--
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
VY
I
V
E
------------------
Y
Q
G
D
E
L
V
A
T
R
G
G
Y
-
N
Q
-
K
V
NVEVDFPGKSTVV
L
T
I
R
P
S
V
F
K
P
L
-----
E
G
A
G
S
P
V
V
S
N
V
D
A
P
S
V
Q
S
R
S
Q
NKD
Y
V
--
E
-
V
G
G
G
N
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
C
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
----
13
PsiBlast_PDB
75.66
32%
-111
- C3 -
3CLT
1
ETFA_METME
D:
[4-316]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
G
L
KK--
S
G
E
D
K
V
V
V
A
VI
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
-
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
D
F
D
PDV
F
E
A
S
V
S
A
L
I
A
---
A
-
H
--
N
--
P
--
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
VY
I
V
E
------------------
Y
Q
G
D
E
L
V
A
T
R
G
G
Y
-
N
Q
-
K
V
NVEVDFPGKSTVV
L
T
I
R
P
S
V
F
K
P
L
-----
E
G
A
G
S
P
V
V
S
N
V
D
A
P
S
V
Q
S
R
S
Q
NKD
Y
V
--
E
-
V
G
G
G
N
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
E
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
----
15
PsiBlast_PDB
74.83
32%
-112
- C3 -
3CLR
2
ETFA_METME
D:
[4-316]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
G
L
KK--
S
G
E
D
K
V
V
V
A
VI
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
-
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
D
F
D
PDV
F
E
A
S
V
S
A
L
I
A
---
A
-
H
--
N
--
P
--
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
VY
I
V
E
------------------
Y
Q
G
D
E
L
V
A
T
R
G
G
Y
-
N
Q
-
K
V
NVEVDFPGKSTVV
L
T
I
R
P
S
V
F
K
P
L
-----
E
G
A
G
S
P
V
V
S
N
V
D
A
P
S
V
Q
S
R
S
Q
NKD
Y
V
--
E
-
V
G
G
G
N
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
A
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
----
11
PsiBlast_PDB
73.96
32%
-113
- C3 -
1O97
1
ETFA_METME
D:
[3-315]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
G
L
KK--
S
G
E
D
K
V
V
V
A
VI
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
-
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
D
F
D
PDV
F
E
A
S
V
S
A
L
I
A
---
A
-
H
--
N
--
P
--
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
VY
I
V
E
------------------
Y
Q
G
D
E
L
V
A
T
R
G
G
Y
-
N
Q
-
K
V
NVEVDFPGKSTVV
L
T
I
R
P
S
V
F
K
P
L
-----
E
G
A
G
S
P
V
V
S
N
V
D
A
P
S
V
Q
S
R
S
Q
NKD
Y
V
--
E
-
V
G
---
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
R
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
----
22
PsiBlast_CBE
73.64
32%
-111
- C3 -
1O96
1
ETFA_METME
Z:
[3-315]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
G
L
KK--
S
G
E
D
K
V
V
V
A
VI
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
-
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
D
F
D
PDV
F
E
A
S
V
S
A
L
I
A
---
A
-
H
--
N
--
P
--
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
VY
I
V
E
------------------
Y
Q
G
D
E
L
V
A
T
R
G
G
Y
-
N
Q
-
K
V
NVEVDFPGKSTVV
L
T
I
R
P
S
V
F
K
P
L
-----
E
G
A
G
S
P
V
V
S
N
V
D
A
P
S
V
Q
S
R
S
Q
NKD
Y
V
---------
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
R
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
----
10
PsiBlast_PDB
73.25
32%
-113
- C3 -
1O96
1
ETFA_METME
B:
[3-315]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
G
L
KK--
S
G
E
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
-
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
D
F
D
P
D
V
F
E
A
S
V
S
A
L
I
A
---
A
-
H
--
N
--
P
--
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
VY
I
V
E
------------------
Y
Q
G
D
E
L
V
A
T
R
G
G
Y
-
N
Q
-
K
V
N
V
E
V
D
F
P
GKS
T
V
V
L
T
I
R
P
S
V
F
K
P
L
-----
E
G
A
G
S
P
V
V
S
N
V
D
A
P
S
V
Q
S
R
S
Q
N
K
D
Y
V
--
E
-
V
----
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
R
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
----
24
PsiBlast_CBE
72.62
32%
-111
- C3 -
1O96
1
ETFA_METME
D:
[3-315]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
G
L
KK--
S
G
E
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
-
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
D
F
D
P
D
V
F
E
A
S
V
S
A
L
I
A
---
A
-
H
--
N
--
P
--
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
VY
I
V
E
------------------
Y
Q
G
D
E
L
V
A
T
R
G
G
Y
-
N
Q
-
K
V
N
V
E
V
D
F
P
GKS
T
V
V
L
T
I
R
P
S
V
F
K
P
L
-----
E
G
A
G
S
P
V
V
S
N
V
D
A
P
S
V
Q
S
R
S
Q
N
K
D
Y
V
--
E
-
V
----
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
R
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
----
23
PsiBlast_CBE
72.61
32%
-112
- C3 -
1O96
1
ETFA_METME
F:
[3-315]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
G
L
KK--
S
G
E
D
K
V
V
V
A
VI
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
-
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
D
F
D
PDV
F
E
A
S
V
S
A
L
I
A
---
A
-
H
--
N
--
P
--
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
VY
I
V
E
------------------
Y
Q
G
D
E
L
V
A
T
R
G
G
Y
-
N
Q
-
K
V
NVEVDFPGKSTVV
L
T
I
R
P
S
V
F
K
P
L
-----
E
G
A
G
S
P
V
V
S
N
V
D
A
P
S
V
Q
S
R
S
Q
NKD
Y
V
--
E
-
V
----
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
R
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
----
2
PsiBlast_PDB
72.15
63%
-121
- C3 -
1T9G
-
ETFA_HUMAN
R:
[21-203]
-
S
T
L
V
I
A
E
H
A
N
D
S
L
-
A
-
P
I
T
L
N
T
I
T
A
A
T
R
L
----
G
G
E
V
S
C
L
V
A
--
G
T
K
C
D
K
-
V
A
-
Q
D
L
C
K
V
A
G
I
A
K
V
L
V
A
Q
H
D
V
Y
K
G
L
---
L
P
E
E
L
T
P
L
I
L
A
T
-
Q
-
K
QF
N
--
Y
--
T
H
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
--
I
I
A
I
K
S
P
---
D
----
T
F
V
R
T
I
Y
A
G
N
A
L
C
T
V
K
C
D
E
-
K
V
-
K
V
-------------
F
S
V
R
G
T
S
F
D
A
A
---
A
T
S
G
-
G
S
A
S
S
E
K
A
S
S
T
S
P
V
E
I
S
E
---
W
L
D
Q
K
----------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
71.86
31%
-104
- C3 -
1O97
1
ETFA_METME
D:
[1-318]
S
K
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
G
L
KKSG
E
D
K
V
V
V
A
V
I
--
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
V
-
N
G
V
D
E
L
V
V
V
K
G
S
S
I
-
D
F
---
D
P
D
V
F
E
A
S
V
S
A
L
I
A
A
H
--
N
--
P
--
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
--
V
Y
I
V
E
Y
Q
GDE
L
----
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
F
P
G
K
S
T
-
V
V
-------------
L
T
I
R
P
S
V
F
K
P
L
---
E
G
A
G
--
S
P
V
V
S
N
V
D
A
P
S
V
Q
S
R
S
Q
---
N
K
D
Y
V
E
V
G
---
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
R
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
A
Q
L
-
7
PsiBlast_PDB
68.43
35%
-95
- C3 -
4L2I
3
?
A:
[67-330]
-------------------------------------------------------------
R
G
A
D
L
V
Y
V
C
Q
D
P
A
F
K
Y
Y
---
S
T
D
E
Y
T
N
A
F
C
E
M
-
I
-
D
--
E
--
Y
QP
S
S
V
F
I
G
A
T
N
D
G
R
D
L
G
P
R
I
A
A
R
V
N
T
G
L
C
A
D
--
C
T
I
L
D
A
E
---
E
DG
L
I
E
W
T
R
P
A
A
G
G
N
I
M
A
T
I
L
C
K
E
-
H
R
P
Q
M
-------------
G
T
V
R
P
K
T
F
K
A
M
EPD
A
S
R
T
-
G
E
V
I
N
Y
T
L
K
N
H
V
D
D
R
V
T
C
---
I
R
R
E
E
-
V
V
S
E
G
E
M
A
I
D
D
A
P
F
V
C
S
G
G
R
G
M
K
A
K
E
N
F
S
L
L
Y
D
L
A
H
A
L
G
G
A
V
G
G
S
R
A
A
V
D
E
G
F
I
E
H
P
R
Q
V
G
Q
S
G
K
T
V
-
T
P
K
I
Y
F
A
C
G
I
S
G
S
V
Q
H
K
A
G
M
S
K
S
D
T
I
V
C
I
N
K
D
P
D
A
P
M
F
E
I
S
K
Y
G
I
V
G
D
A
L
K
I
L
P
L
L
-----
6
PsiBlast_PDB
67.71
35%
-95
- C3 -
4KPU
3
?
A:
[67-330]
-------------------------------------------------------------
R
G
A
D
L
V
Y
V
C
Q
D
P
A
F
K
Y
Y
---
S
T
D
E
Y
T
N
A
F
C
E
M
-
I
-
D
--
E
--
Y
QP
S
S
V
F
I
G
A
T
N
D
G
R
D
L
G
P
R
I
A
A
R
V
N
T
G
L
C
A
D
--
C
T
I
L
D
A
E
---
E
DG
L
I
E
W
T
R
P
A
A
G
G
N
I
M
A
T
I
L
C
K
E
-
H
R
P
Q
M
-------------
G
T
V
R
P
K
T
F
K
A
M
EPD
A
S
R
T
-
G
E
V
I
N
Y
T
L
K
N
H
V
D
D
R
V
T
C
---
I
R
R
E
E
-
V
V
S
E
G
E
M
A
I
D
D
A
P
F
V
C
S
G
G
R
G
M
K
A
K
E
N
F
S
L
L
Y
D
L
A
H
A
L
G
G
A
V
G
G
S
R
A
A
V
D
E
G
F
I
E
H
P
R
Q
V
G
Q
S
G
K
T
V
-
T
P
K
I
Y
F
A
C
G
I
S
G
S
V
Q
H
K
A
G
M
S
K
S
D
T
I
V
C
I
N
K
D
P
D
A
P
M
F
E
I
S
K
Y
G
I
V
G
D
A
L
K
I
L
P
L
L
-----