@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2991: (2016-02-12 )
MAVYNYDVVILGTGPAGEGAAMNASKYGRKLAVVDSRRVVGGNCTHLGTIPSKALRHSVKQIIEFNTNPMFRQIGEPRWFSFPDVLKSADRVISKQVASRTGYYARNRIDMFTGTASFVDERTVEVVTPSGAVERLVADQFVIATGSRPYRPSDINFNHPRVYDSDTILSLSHTPRRLIIYGAGVIGCEYASIFSGLGVLVDLIDTRDQLLSFLDDEISDALSYHLRNNNVLIRHNEEYERVEGLDNGVILHLKSGKKIKADALLWCNGRTGNTDKLGLENVGIKVNSRGQIEVDENYRTSVSNIFAAGDVIGWPSLASAAYDQGRSAAGNIVESDSWRFVNDVPTGIYTIPEISSIGKNESELTAAKIPYEVGKAFFKGMARAQISNEPVGMLKILFHRETLEILGVHCFGDQASEIVHIGQAIMNQPGELNTLKYFVNTTFNYPTMAEAYRVAAFDGLNRLF
Atome Classification :
(20 SA)
.........10........20........30.....------.------..40........50........60.--.......70...-.-.----.---.-.80.--.......90........100.......110.......120.......130.......140.....--..150.......----160.......170-.-......180.......190.......200.......210-.......220......-.230.......240.....-..250.--.---.-----.-----..---...260----..--.....-----.270.......280.......290.......300.......310..-.....320.......330.......340..-.....350.......360.......370.......380.......390.......400.......410.....-..-420...-....430.......440.......450....--...460..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
V
Y
N
Y
D
V
V
I
L
GTGPAGEGAAM
N
A
S
KYG
R
K
L
A
V
V
DS------
R
------
R
VVGGNCTHLGT
I
P
S
K
A
L
R
H
S
V
K
Q
I
--
I
EFNT
N
P
M
F
R
QI-G-E----P---R-WFS
F
--
P
D
V
L
K
S
A
D
R
V
I
S
K
Q
V
A
S
RTGYYAR
N
R
I
D
M
FTG
T
A
S
FVDE
R
T
V
E
V
VTP
S
G
A
V
E
R
L
VAD
Q
F
V
I
ATGS--RPYRPSDINFNH----P
R
V
YDSD
T
I
L
SLS-H-TP
R
R
L
I
I
Y
GAGVIG
C
E
Y
A
S
I
F
S
G
L
G
V
L
V
D
L
ID
T
R
D
Q
L
L
S
-
F
L
D
D
E
I
S
D
A
L
S
Y
HLRN-N
N
V
L
I
RHN
E
E
Y
E
R
V
EGLDN-
G
V
I
--
L
--
H
---L-----K-----SG---
K
K
IKA-----
D
A
--
L
L
W
CN-----GRTGNTDKLGL
E
N
V
G
I
K
VNSRG
Q
I
E
VDENY
R
T
S
V
S
N
I
FAAGDVIGW-
P
S
L
A
S
A
A
Y
DQGRSAAGNIVESDS
W
R
F
VNDV-PTGIYTIP
E
I
S
SIGKNESEL
T
A
AKI
P
Y
E
V
G
K
A
F
F
K
G
M
A
R
A
QISNE
P
V
G
M
L
K
I
L
F
H
R
E
T
L
E
I
L
G
V
H
CFGD
Q
A
S
E
-
I
V
-
H
I
G
Q
A
I
-MNQPGELN
T
L
K
Y
F
VNTTFNY
P
T
M
A
E
A
Y
R
V
A
A
--FD
G
L
N
RLF
39
HHSearch
94.12
32%
-92
- C1 -
2YQU
4
?
A:
[1-451]
----
M
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
------
E
------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
--
Y
E
A
K
K
G
L
--
L
G
A
-
K
-
V
K---
G
---
V
-
E
L
D
L
--
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
L
V
E
-
E
T
--
G
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
--
A
P
L
I
P
P
W
A
Q
V
D
Y
----
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
-
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
-
G
A
R
--
V
--
E
---
L
-----
E
-----
G
G
---
E
V
L
E
A
-----
D
R
--
V
L
V
A
V
-----
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
H
V
D
Y
Q
A
I
-
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
-
V
L
-
A
E
A
A
L
A
-
L
F
F
K
A
---
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
--
L
A
A
W
E
R
--
36
HHSearch
93.75
31%
-92
- C1 -
2EQ6
2
?
A:
[4-458]
--
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
------
G
------
E
-
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
--
H
H
L
K
V
A
E
---
G
F
-
G
-
L
KA--
K
---
P
-
E
L
D
L
--
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
E
V
E
V
G
-----
G
E
R
Y
G
A
K
S
L
I
L
A
T
G
S
--
E
P
L
E
L
K
--
G
F
P
F
G---
E
D
V
W
D
S
T
R
A
L
K
V
E
E
G
-
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
-
Q
G
D
P
E
T
A
A
L
L
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
-
G
L
H
--
V
--
R
---
L
E
PAEG
G
-----
E
G
---
E
E
V
V
V
-----
D
K
--
V
L
V
A
V
-----
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
D
Y
-
Q
V
-
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
-
L
I
-
A
E
A
A
L
A
-
L
E
M
G
A
---
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
--
E
A
F
H
K
Q
A
-
41
HHSearch
92.35
31%
-98
* C1 *
1EBD
2
DLDH1_GEOSE
A:
[2-455]
---
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
------
G
-------
N
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
R
Y
--
E
Q
A
K
H
S
E
---
E
M
-
G
-
I
K
A
E
-
N
---
V
-
T
I
D
F
--
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
T
V
R
V
V
N
G
D
-
S
A
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
--
R
P
I
E
L
P
N
F
K
F
S
-----
N
R
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
-
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
E
D
-
G
V
T
--
V
--
T
---
Y
E
----
A
-----
N
G
E
T
-
K
T
I
D
A
-----
D
Y
--
V
L
V
T
V
-----
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
G
-
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
S
A
V
D
Y
V
A
I
-
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
-
M
I
-
A
E
L
G
L
A
-
I
E
A
G
M
---
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
--
E
V
A
L
----
25
HHSearch
90.85
29%
-93
- C1 -
2QAE
2
DLDH_TRYCR
A:
[1-463]
---
N
P
Y
D
V
V
V
I
G
G
G
P
G
G
Y
V
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
------
R
------
G
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
--
H
D
A
H
A
--
N
F
A
R
Y
-
G
-
L
MGGE
G
---
V
-
T
M
D
S
--
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
F
E
T
A
H
S
I
R
V
N
G
L
D
G
K
Q
E
M
L
E
T
K
K
T
I
I
A
T
G
S
--
E
P
T
E
L
P
F
L
P
F
D
E
----
K
V
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
-
T
L
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
E
K
M
K
F
M
T
S
T
K
V
V
G
G
T
N
N
G
D
-
S
V
S
--
L
E
V
E
---
G
-----
K
-------
R
--
E
T
V
T
C
-----
E
A
--
L
L
V
S
V
-----
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
P
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
G
H
V
N
Y
G
V
I
-
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
-
L
I
-
G
E
A
C
L
A
-
M
E
Y
G
A
---
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
--
M
A
L
F
A
---
4
PsiBlast_PDB
89.93
31%
-95
- C1 -
1EBD
2
DLDH1_GEOSE
A:
[5-451]
------
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
------
G
------
N
L
-
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
R
Y
--
E
Q
A
K
H
S
E
E
M
G
I
K
-
A
-
E
----
N
---
V
-
T
I
D
F
--
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
T
V
R
V
V
N
G
D
S
A
-
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
--
R
P
I
E
L
P
N
F
K
F
S
N
-----
R
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
-
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
E
D
-
G
V
T
--
V
--
T
---
Y
-----
E
-----
A
N
G
E
T
K
T
I
D
A
-----
D
Y
--
V
L
V
T
V
-----
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
G
-
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
S
A
V
D
Y
V
A
I
-
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
-
E
L
G
L
A
I
---
E
A
G
--
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
----------
23
PsiBlast_CBE
89.68
31%
-92
- C1 -
1EBD
2
DLDH1_GEOSE
B:
[5-451]
------
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
------
G
------
N
L
-
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
R
Y
--
E
Q
A
K
H
S
E
E
M
G
I
K
-
A
-
E
----
N
---
V
-
T
I
D
F
--
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
T
V
R
V
V
N
G
D
S
A
-
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
--
R
P
I
E
L
P
N
F
K
F
S
N
-----
R
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
-
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
E
D
-
G
V
T
--
V
--
T
---
Y
-----
E
-----
A
N
GET
K
T
I
D
A
-----
D
Y
--
V
L
V
T
V
-----
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
G
-
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
S
A
V
D
Y
V
A
I
-
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
-
E
L
G
L
A
I
---
E
A
G
--
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
----------
26
HHSearch
89.67
28%
-95
- C1 -
1ZMD
3
DLDH_HUMAN
A:
[3-468]
-
Q
P
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
------
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
Y
Y
--
H
M
A
H
G
T
-
D
F
A
S
R
-
G
-
I
----
E
MS
E
V
-
R
L
N
L
--
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
--
E
V
T
P
F
P
G
I
T
I
D
E
----
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
G
K
I
D
V
S
I
--
E
---
A
-----
A
-----
S
G
GK
A
E
V
I
T
C
-----
D
V
--
L
L
V
C
I
-----
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
G
A
V
H
I
D
Y
N
C
V
-
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
-
M
V
-
N
E
A
A
L
A
-
L
E
Y
G
A
---
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
--
L
A
A
S
F
---
3
PsiBlast_PDB
89.56
30%
-94
- C1 -
3URH
3
?
A:
[26-482]
-----
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
------
R
------
S
T
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
E
M
F
H
Q
A
Q
H
G
L
E
A
L
G
V
E
V
-
A
-
N
----
P
---
K
--
L
N
L
--
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
V
S
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
K
V
L
G
Q
G
K
V
S
V
T
N
E
K
G
E
E
Q
V
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
G
I
P
G
V
E
V
A
F
D
E
----
K
T
I
V
S
S
T
G
A
L
A
L
E
-
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
-
G
M
D
G
E
V
A
K
Q
L
Q
R
M
L
T
K
-
Q
G
I
D
F
K
L
G
A
K
V
T
G
A
V
K
S
G
D
-
G
A
K
--
V
--
T
F
E
P
V
-----
K
-----
G
G
---
E
A
T
T
L
-----
D
A
E
V
V
L
I
A
T
-----
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
R
G
-
P
M
L
A
H
K
A
E
D
E
G
V
A
V
A
-
E
I
I
A
G
Q
A
G
H
V
N
Y
D
V
I
P
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
-
M
I
-
H
E
I
A
V
L
-
M
E
F
G
G
S
S
E
D
L
G
---
R
T
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
--
L
-------
31
HHSearch
89.10
27%
-95
- C1 -
3LAD
2
DLDH_AZOVI
A:
[1-468]
--
S
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
------
Y
KGKEGK
T
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
F
--
H
E
A
H
E
S
F
K
--
L
H
-
G
-
I
----
S
T
G
E
V
-
A
I
D
V
--
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
K
L
L
A
G
K
K
V
E
V
T
A
A
D
G
S
S
Q
V
L
D
T
E
N
V
I
L
A
S
G
S
--
K
P
V
E
I
P
P
A
P
V
D
Q
----
D
V
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
-
A
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
K
-
Q
G
L
K
I
L
L
G
A
R
V
T
G
T
E
V
K
N
K
-
Q
V
T
--
V
--
K
---
F
-----
V
DA
E
--
G
E
---
K
S
Q
A
F
-----
D
K
--
L
I
V
A
V
-----
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
R
G
-
A
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
H
K
A
Q
M
N
Y
D
L
I
-
P
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
-
L
V
-
Q
Q
G
A
I
A
-
M
E
F
G
T
---
S
A
E
D
L
G
M
M
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
--
L
A
V
S
G
H
A
-
28
HHSearch
88.71
30%
-93
- C1 -
3URH
3
?
A:
[26-486]
-----
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
------
R
------
S
T
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
E
M
F
--
H
Q
A
Q
H
G
L
--
E
A
L
-
G
-
V
E
V
A
-
N
---
P
-
K
L
N
L
--
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
V
S
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
K
V
L
G
Q
G
K
V
S
V
T
N
E
K
G
E
E
Q
V
L
E
A
K
N
V
V
I
A
T
G
S
--
D
V
A
G
I
P
--
G
V
E
V
A
F
DE
K
T
I
V
S
S
T
G
A
L
A
L
E
-
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
-
G
M
D
G
E
V
A
K
Q
L
Q
R
M
L
T
K
-
Q
G
I
D
F
K
L
G
A
K
V
T
G
A
V
K
S
G
D
-
G
A
K
--
V
--
T
---
F
E
PVKG
G
-----
E
A
---
T
T
L
D
A
-----
E
V
--
V
L
I
A
T
-----
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
R
G
-
P
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
A
G
Q
A
G
H
V
N
Y
D
V
I
-
P
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
-
M
I
-
H
E
I
A
V
L
-
M
E
F
G
G
---
S
S
E
D
L
G
R
T
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
--
L
S
T
F
F
---
15
PsiBlast_PDB
87.72
27%
-98
- C1 -
3LAD
2
DLDH_AZOVI
A:
[3-462]
----
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
YKGKEG
K
------
T
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
F
--
H
E
A
H
E
S
F
K
L
H
G
I
-
S
-
T
----
G
---
E
V
A
I
D
V
--
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
K
L
L
A
G
K
K
V
E
V
T
A
A
D
G
S
S
Q
V
L
D
T
E
N
V
I
L
A
S
G
S
--
K
P
V
E
I
P
P
A
P
V
D
Q
----
D
V
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
-
A
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
K
-
Q
G
L
K
I
L
L
G
A
R
V
T
G
T
E
V
K
N
K
-
Q
V
T
--
V
--
K
---
F
V
D---
A
-----
E
G
---
E
K
S
Q
A
F----
D
K
--
L
I
V
A
V
-----
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
R
G
-
A
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
H
K
A
Q
M
N
Y
D
L
I
-
P
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
-
L
V
-
Q
Q
G
A
I
A
-
M
E
F
G
T
S
A
E
D
L
G
M
M
V
---
F
A
H
P
A
L
S
E
A
L
H
E
A
A
--
L
-------
14
PsiBlast_PDB
87.66
29%
-95
- C1 -
1LPF
2
DLDH_PSEFL
A:
[3-462]
----
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
YIGKEG
K
------
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
--
H
E
--
A
K
E
A
F
K
V
H
-
G
I
E
----
A
---
K
-
G
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
--
R
P
V
E
I
P
P
A
P
L
S
D
----
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
-
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
K
K
-
Q
V
T
--
V
--
T
---
F
-----
T
-----
D
A
N
G
E
Q
K
E
T
F
-----
D
K
--
L
I
V
A
V
-----
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
G
-
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
A
Q
M
N
Y
D
L
I
-
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
-
L
V
-
Q
Q
G
A
I
G
-
M
E
F
G
T
S
A
E
D
L
G
M
M
V
---
F
S
H
P
T
L
S
E
A
L
H
E
A
A
--
L
-------
32
HHSearch
87.50
29%
-92
- C1 -
1DXL
2
DLDH_PEA
A:
[4-466]
--
S
D
E
N
D
V
V
I
I
G
G
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
T
C
I
E
K
------
R
------
G
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
S
S
H
M
Y
--
H
E
A
K
H
S
F
--
A
N
H
-
G
-
V
----
K
VS
N
V
-
E
I
D
L
--
A
A
M
M
G
Q
K
D
K
A
V
S
N
L
T
R
G
I
E
G
L
F
K
K
N
K
V
T
Y
V
K
G
Y
G
K
F
V
S
P
S
E
I
S
V
D
T
I
E
G
E
N
T
V
V
K
G
K
H
I
I
I
A
T
G
S
--
D
V
K
S
L
P
G
V
T
I
D
E
----
K
K
I
V
S
S
T
G
A
L
A
L
S
-
E
-
I
P
K
K
L
V
V
I
G
A
G
Y
I
G
L
E
M
G
S
V
W
G
R
I
G
S
E
V
T
V
V
E
F
A
S
E
I
V
P
-
T
M
D
A
E
I
R
K
Q
F
Q
R
S
L
E
K
-
Q
G
M
K
F
K
L
K
T
K
V
V
G
V
D
T
S
G
D
-
G
V
K
--
L
--
T
---
V
-----
E
PSAGG
E
Q
---
T
I
I
E
A
-----
D
V
--
V
L
V
S
A
-----
G
R
T
P
F
T
S
G
L
N
L
D
K
I
G
V
E
T
D
K
L
G
R
I
L
V
N
E
R
F
S
T
N
V
S
G
V
Y
A
I
G
D
V
I
P
G
-
P
M
L
A
H
K
A
E
E
D
G
V
A
C
V
E
Y
L
A
G
K
V
G
H
V
D
Y
D
K
V
-
P
G
V
V
Y
T
N
P
E
V
A
S
V
G
K
T
E
E
Q
V
K
E
T
G
V
E
Y
R
V
G
K
F
P
F
M
A
N
S
R
A
K
A
I
D
N
A
E
G
L
V
K
I
I
A
E
K
E
T
D
K
I
L
G
V
H
I
M
A
P
N
A
G
E
-
L
I
-
H
E
A
A
I
A
-
L
Q
Y
D
A
---
S
S
E
D
I
A
R
V
C
H
A
H
P
T
M
S
E
A
I
K
E
A
A
--
M
A
T
Y
D
K
--
2
PsiBlast_PDB
86.50
34%
-93
- C1 -
2YQU
2
?
A:
[2-411]
-----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
------
E
------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
--
Y
E
A
K
K
G
L
L
G
A
K
V
---
K
----
G
---
V
-
E
L
D
L
--
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
-
L
V
E
E
T
G
--
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
--
A
P
L
I
P
P
W
A
Q
V
D
Y
----
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
-
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
-
G
A
R
--
V
--
E
---
L
-----
E
-----
G
G
---
E
V
L
E
A
-----
D
R
--
V
L
V
A
V
-----
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
H
V
D
Y
Q
A
I
-
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
-
V
L
-------------------------------------------------
6
PsiBlast_PDB
85.05
30%
-88
- C1 -
4JQ9
14
?
A:
[9-461]
-------
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
------
Y
------
N
T
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
K
V
I
--
E
E
A
K
A
L
A
E
H
G
I
V
F
G
-
E
----
P
---
K
--
T
D
I
--
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
L
A
G
M
A
K
G
R
K
V
K
V
V
N
G
L
G
K
F
T
G
A
N
T
L
E
V
E
G
E
N
G
K
T
-
V
I
N
F
D
N
A
I
I
A
A
G
S
--
R
P
I
Q
L
P
F
I
P
H
E
D
----
P
R
I
W
D
S
T
D
A
L
E
L
K
-
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
-
A
A
D
K
D
I
V
K
V
F
T
K
R
I
S
K
-
K
F
N
L
M
L
E
T
K
-
V
T
A
V
E
A
K
E
D
-
G
I
Y
--
V
--
T
---
M
-----
E
------
G
---
K
K
A
P
A
E
P
Q
R
Y
D
A
--
V
L
V
A
I
-----
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
G
Q
-
P
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
A
G
K
K
H
Y
F
D
P
K
V
I
-
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
G
G
E
-
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
-----
T
I
H
A
H
P
T
L
H
E
S
V
G
L
A
A
E
V
F
E
G
-----
5
PsiBlast_PDB
84.68
30%
-87
- C1 -
4JDR
9
DLDH_ECOLI
A:
[9-461]
-------
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
------
Y
------
N
T
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
K
V
I
--
E
E
A
K
A
L
A
E
H
G
I
V
F
G
-
E
----
P
---
K
--
T
D
I
--
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
L
A
G
M
A
K
G
R
K
V
K
V
V
N
G
L
G
K
F
T
G
A
N
T
L
E
V
E
G
E
N
G
K
T
-
V
I
N
F
D
N
A
I
I
A
A
G
S
--
R
P
I
Q
L
P
F
I
P
H
E
D
----
P
R
I
W
D
S
T
D
A
L
E
L
K
-
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
-
A
A
D
K
D
I
V
K
V
F
T
K
R
I
S
K
-
K
F
N
L
M
L
E
T
K
-
V
T
A
V
E
A
K
E
D
-
G
I
Y
--
V
--
T
---
M
-----
E
------
G
---
K
K
A
P
A
E
P
Q
R
Y
D
A
--
V
L
V
A
I
-----
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
G
Q
-
P
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
A
G
K
K
H
Y
F
D
P
K
V
I
-
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
G
G
E
-
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
-----
T
I
H
A
H
P
T
L
H
E
S
V
G
L
A
A
E
V
F
E
G
-----
21
PsiBlast_CBE
84.61
34%
-92
- C1 -
2YQU
3
?
B:
[2-411]
-----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
------
E
------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
--
Y
E
A
K
K
G
L
L
G
A
K
V
---
K
----
G
---
V
-
E
L
D
L
--
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
-
L
V
E
E
T
G
--
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
--
A
P
L
I
P
P
W
A
Q
V
D
Y
----
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
-
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
-
G
A
R
--
V
--
E
---
L
-----
E
-----
G
G
---
E
V
L
E
A
-----
D
R
--
V
L
V
A
V
-----
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
H
V
D
Y
Q
A
I
-
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
-
V
L
-------------------------------------------------
22
PsiBlast_CBE
84.48
34%
-93
- C1 -
2EQ7
2
?
B:
[2-411]
-----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
------
E
------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
--
Y
E
A
K
K
G
L
L
G
A
K
V
---
K
----
G
---
V
-
E
L
D
L
--
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
-
L
V
E
E
T
G
--
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
--
A
P
L
I
P
P
W
A
Q
V
D
Y
----
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
-
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
-
G
A
R
--
V
--
E
---
L
-----
E
-----
G
G
---
E
V
L
E
A
-----
D
R
--
V
L
V
A
V
-----
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
H
V
D
Y
Q
A
I
-
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
-
V
L
-------------------------------------------------
18
PsiBlast_PDB
84.41
29%
-85
- C1 -
2EQ6
2
?
A:
[6-451]
----
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
------
G
------
E
V
-
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
--
H
H
L
K
V
A
E
G
F
G
L
K
-
A
-
K
----
P
---
E
--
L
D
L
--
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
E
V
E
V
-----
G
G
E
R
Y
G
A
K
S
L
I
L
A
T
G
S
--
E
P
L
E
L
K
G
F
P
F
G
E
-----
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
-
Q
G
D
P
E
T
A
A
L
L
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
-
G
L
H
--
V
--
R
---
L
-----
E
-----
P
A
---
E
G
G
E
G
-----
E
E
--
V
V
V
D
K
V
L
V
AV
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
-
A
F
D
Y
Q
V
-
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
-
L
I
-
A
E
A
A
L
A
-
L
E
M
G
A
T
L
T
D
L
A
L
---
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
----------
1
PsiBlast_PDB
84.35
34%
-92
- C1 -
2EQ7
2
?
A:
[2-411]
-----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
------
E
------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
--
Y
E
A
K
K
G
L
L
G
A
K
V
---
K
----
G
---
V
-
E
L
D
L
--
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
-
L
V
E
E
T
G
--
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
--
A
P
L
I
P
P
W
A
Q
V
D
Y
----
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
-
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
-
G
A
R
--
V
--
E
---
L
-----
E
-----
G
G
---
E
V
L
E
A
-----
D
R
--
V
L
V
A
V
-----
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
H
V
D
Y
Q
A
I
-
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
-
V
L
-------------------------------------------------