@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3014: (2016-02-13 )
MIYQGKAITVKPLEGGIVELNFDLKGESVNKFNRLTLSELRAAVDAIKADASVKGVIVTSGKDVFIVGADITEFVDNFQLPDEELMAGNLEANKIFSDFEDLDVPTVAAINGIALGGGLEMCLAADFRVMSATAKVGLPEVKLGIYPGFGGTVRLPRLIGCDNAVEWIASGKENKAEDALKVGAVDAVVAPEQLQAAALDLAKRAVAGELDHKARRQPKLEKLKLNAIEQMMAFETAKGFVAGQAGPNYPAPVEAIKSIQKAANFGRDKALEVEAAGFVKLAKTSVAQSLIGLFLNDQELKKKAKKYDEVAKDVKLAAVLGAGIMGGGIAYQSALKGTPILMKDIREEGIQMGLNEAAKLLGKRVEKGRLTPAKMAEALNGIRPTMSYGDFGNVDIVVEAVVENPKVKQAVLAEVEGAVKEDAIIASNTSTISISLLAQALKRPENFCGMHFFNPVHMMPLVEVIRGEKTGETAIATTVAYAKKMGKSPIVVNDCPGFLVNRVLFPYFGGFAKLLSFGVDFVRIDKVMEKFGWPMGPAYLSDVVGIDTGHHGRDVMAEGFPDRMAVEGKTAVDVMYEANRLGQKNGKGFYAYETDKRGKPKKVTDPQAYEVLKPIVVEQREVTDEDIVNFMMIPLCLETVRCLEDGIVETAAEADMGLIYGIGFPPFRGGALRYIDSIGVAEFVALADKYAELGALYHPTAKLREMAKNGQKFFG
Atome Classification :
(45 SA)
.........10........20........30........40........50-........60........70........80........90........100.......110.......120.......130.--......140.......150.......160..-.....170.......180.......190........200.......--------210......------.220..-.....230.......240.......250.......260.......270.......280.......290.....-..300.-----...--...--310.-......320.......330.......340......-------.350-.........360..------------...--.-----.370----........380......-.390-........400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510...-...-.-520.--......-530.--.......540.......550..-------.....560.....----...570--.......580.......590...--....600.......610.-...-------...620------------.......630.......640.......650.......660.......670...------....680.......690-.-......700.......710...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIYQG
K
A
I
T
V
K
PLEG
G
I
V
E
L
N
F
D
LKGESVN
K
F
N
RL
T
L
S
E
L
R
A
A
V
D
A
I
KADA-
S
V
K
G
V
I
VTSG
K
D
V
F
I
VGA
D
I
T
E
F
V
D
NFQL
P
D
E
E
L
MAGNL
E
A
N
K
I
F
S
D
F
E
DLDVP
T
V
A
A
I
N
G
I
ALGG
G
L
E
M
C
L
A
AD
F
R
V
M
SAT--AKVGL
P
E
V
K
L
G
I
YPGFGGTVRLPRLIGCD
N
A
-
V
E
W
I
ASGKENK
A
E
D
A
L
KVGA
V
D
AVV
A
P
-
E
Q
L
Q
A
A
A
L
D
L
A
K
R
A
VAGE--------L
D
H
K
A
RRQP------
K
L
E
K
L
K
-
L
N
A
I
E
Q
M
M
A
F
E
TAKGFVAGQAGPNYPA
P
V
E
A
I
K
S
I
Q
K
A
A
NFGRD
K
A
L
E
V
EAA
G
F
V
K
L
A
K
T
S
V
A
Q
S
L
I
G
L
FL
N
D
-
Q
E
L
K
K
K
-----
A
K
K
--
Y
D
E
--
V
A
K
D
-
V
K
L
A
A
V
LG
A
G
IMG
G
G
I
A
Y
Q
S
ALKGT
P
I
L
M
K
D
I
R
E
E
-------
G
I
---QM
G
L
N
E
A
A
K
L
L
G
K
R
------------
V
EK--G-----RL
T
-----
P
A
K
M
A
E
A
L
NGIRPTMSY-GD-F-GNV
D
I
V
V
E
A
V
VENP
K
V
K
Q
A
V
L
A
E
V
EGAVKE
D
A
I
I
ASNT
S
T
I
S
I
S
L
L
A
Q
A
L
KR
P
E
N
FCGMHFF
N
P
V
H
M
M
P
L
V
E
V
IRGEKTG
E
T
A
I
A
T
T
V
A
Y
A
K
KMGKS
P
I
V
VNDC
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
L
-
S
FG-V-
D
F
V
R
--
I
D
K
V
M
E
-
K
F-G--WPM
G
P
A
Y
L
S
D
V
VGIDTGHH
G
R
D
-------
V
M
AEGFP-D
R
M
AV----EGK
T
A
V
--
D
V
M
Y
E
A
N
RLGQKNG
K
G
F
Y
A
YETD--KRGKPKKVTD
P
Q
A
Y
E
V
L
K
-
P
I
V
-------
V
E
QREV------------
T
D
E
D
I
V
N
F
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
AEAD
M
G
L
I
Y
GIGFPPFRG
G
A
L
R
Y
I
------
D
SI
G
V
A
E
F
V
A
L
A
D
K
Y
A
E
-
L
-GALYHP
T
A
K
L
R
E
M
A
KNGQKFFG
104
Fugue
99.43
86%
-108
- C2 -
1WDK
4
FADB_PSEFR
A:
[1-715]
M
I
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
-
S
V
K
G
V
I
V
S
S
G
K
D
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
S
--
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
-
D
K
L
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
--------
L
D
Y
K
A
K
R
Q
P
------
K
L
E
K
L
K
-
L
N
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
G
P
N
Y
P
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
K
K
-----
A
K
V
--
Y
D
K
--
I
A
K
D
-
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
-------
G
I
---
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
------------
V
D
K
--
G
-----
R
M
T
-----
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
-
G
D
-
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
-
S
A
G
-
V
-
D
F
V
R
--
I
D
K
V
M
E
-
K
F
-
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
-------
V
M
A
E
G
F
P
-
D
R
M
K
D
----
D
R
R
S
A
I
--
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
---------
E
K
K
L
V
D
S
S
V
L
E
V
L
K
-
P
I
V
-------
Y
E
Q
R
D
V
------------
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
I
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
-
L
-
G
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
24
PsiBlast_CBE
99.02
86%
-108
- C2 -
1WDK
3
FADB_PSEFR
B:
[1-715]
M
I
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
-
S
V
K
G
V
I
V
S
S
G
K
D
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
S
--
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
-
D
K
L
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
--------
L
D
Y
K
A
K
R
Q
P
------
K
L
E
K
L
K
-
L
N
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
G
P
N
Y
P
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
K
K
-----
A
K
V
--
Y
D
K
--
I
A
K
D
-
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
-------
G
I
---
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
------------
V
D
K
--
G
-----
R
M
T
-----
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
-
G
D
-
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
-
S
A
G
-
V
-
D
F
V
R
--
I
D
K
V
M
E
-
K
F
-
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
-------
V
M
A
E
G
F
P
-
D
R
M
K
D
----
D
R
R
S
A
I
--
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
A
D
------
Q
K
K
L
V
D
S
S
V
L
E
V
L
K
-
P
I
V
-------
Y
E
Q
R
D
V
------------
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
I
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
-
L
-
G
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
2
PsiBlast_PDB
98.34
86%
-108
- C2 -
1WDM
3
FADB_PSEFR
A:
[1-715]
M
I
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
-
S
V
K
G
V
I
V
S
S
G
K
D
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
S
--
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
-
D
K
L
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
--------
L
D
Y
K
A
K
R
Q
P
------
K
L
E
K
L
K
-
L
N
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
G
P
N
Y
P
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
K
K
-----
A
K
V
--
Y
D
K
--
I
A
K
D
-
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
-------
G
I
---
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
------------
V
D
K
--
G
-----
R
M
T
-----
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
-
G
D
-
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
-
S
A
G
-
V
-
D
F
V
R
--
I
D
K
V
M
E
-
K
F
-
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
-------
V
M
A
E
G
F
P
-
D
R
M
K
D
----
D
R
R
S
A
I
--
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
----------
K
K
L
V
D
S
S
V
L
E
V
L
K
-
P
I
V
-------
Y
E
Q
R
D
V
------------
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
I
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
-
L
-
G
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
22
PsiBlast_CBE
98.33
86%
-108
- C2 -
1WDM
1
FADB_PSEFR
B:
[1-715]
M
I
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
-
S
V
K
G
V
I
V
S
S
G
K
D
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
S
--
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
-
D
K
L
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
--------
L
D
Y
K
A
K
R
Q
P
------
K
L
E
K
L
K
-
L
N
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
G
P
N
Y
P
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
K
K
-----
A
K
V
--
Y
D
K
--
I
A
K
D
-
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
-------
G
I
---
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
------------
V
D
K
--
G
-----
R
M
T
-----
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
-
G
D
-
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
-
S
A
G
-
V
-
D
F
V
R
--
I
D
K
V
M
E
-
K
F
-
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
-------
V
M
A
E
G
F
P
-
D
R
M
K
D
----
D
R
R
S
A
I
--
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
-------
K
Q
K
K
L
V
D
S
S
V
L
E
V
L
K
-
P
I
V
-------
Y
E
Q
R
D
V
------------
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
I
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
-
L
-
G
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
23
PsiBlast_CBE
97.99
86%
-106
* C2 *
1WDL
2
FADB_PSEFR
B:
[1-715]
M
I
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
-
S
V
K
G
V
I
V
S
S
G
K
D
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
S
--
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
-
D
K
L
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
--------
L
D
Y
K
A
K
R
Q
P
------
K
L
E
K
L
K
-
L
N
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
G
P
N
Y
P
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
K
K
-----
A
K
V
--
Y
D
K
--
I
A
K
D
-
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
-------
G
I
---
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
------------
V
D
K
--
G
-----
R
M
T
-----
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
-
G
D
-
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
-
S
A
G
-
V
-
D
F
V
R
--
I
D
K
V
M
E
-
K
F
-
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
-------
V
M
A
E
G
F
P
-
D
R
M
K
D
----
D
R
R
S
A
I
--
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
-----------
K
L
V
D
S
S
V
L
E
V
L
K
-
P
I
V
-------
Y
E
Q
R
D
V
------------
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
I
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
-
L
-
G
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
21
PsiBlast_CBE
97.97
86%
-107
- C2 -
2D3T
1
FADB_PSEFR
B:
[1-715]
M
I
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
-
S
V
K
G
V
I
V
S
S
G
K
D
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
S
--
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
-
D
K
L
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
--------
L
D
Y
K
A
K
R
Q
P
------
K
L
E
K
L
K
-
L
N
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
G
P
N
Y
P
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
K
K
-----
A
K
V
--
Y
D
K
--
I
A
K
D
-
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
-------
G
I
---
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
------------
V
D
K
--
G
-----
R
M
T
-----
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
-
G
D
-
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
-
S
A
G
-
V
-
D
F
V
R
--
I
D
K
V
M
E
-
K
F
-
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
-------
V
M
A
E
G
F
P
-
D
R
M
K
D
----
D
R
R
S
A
I
--
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
A
D
------
Q
K
K
L
V
D
S
S
V
L
E
V
L
K
-
P
I
V
-------
Y
E
Q
R
D
V
------------
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
I
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
-
L
-
G
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
1
PsiBlast_PDB
97.57
86%
-103
- C2 -
1WDL
4
FADB_PSEFR
A:
[1-715]
M
I
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
-
S
V
K
G
V
I
V
S
S
G
K
D
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
S
--
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
-
D
K
L
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
--------
L
D
Y
K
A
K
R
Q
P
------
K
L
E
K
L
K
-
L
N
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
G
P
N
Y
P
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
K
K
-----
A
K
V
--
Y
D
K
--
I
A
K
D
-
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
-------
G
I
---
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
------------
V
D
K
--
G
-----
R
M
T
-----
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
-
G
D
-
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
-
S
A
G
-
V
-
D
F
V
R
--
I
D
K
V
M
E
-
K
F
-
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
-------
V
M
A
E
G
F
P
-
D
R
M
K
D
----
D
R
R
S
A
I
--
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
A
D
--
K
K
G
K
Q
K
K
L
V
D
S
S
V
L
E
V
L
K
-
P
I
V
-------
Y
E
Q
R
D
V
------------
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
I
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
-
L
-
G
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
27
PsiBlast_CBE
70.60
33%
-82
- C2 -
4B3H
11
?
B:
[30-724]
---------------
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
KG
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
PDGAGVQP
W
D
K
K
G
Y
K
M
P
------
G
G
T
P
S
S
-
P
G
L
A
A
I
L
P
S
F
P
S
--
N
L
R
K
Q
L
K
G
A
P
M
P
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
A
G
-----
G
S
R
--
P
E
G
--
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
-------
A
A
---
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
------------
L
E
R
--
G
-----
R
T
T
-----
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
-
A
D
-
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
-
G
E
G
-
V
-
E
P
A
S
--
I
E
Q
A
G
S
-
Q
A
-
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
-------
A
T
R
K
G
V
E
-
D
A
G
G
T
YQPH
P
A
E
A
V
V
--
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
--
K
R
S
G
----
L
W
P
G
L
R
E
T
F
K
-
S
----------
G
S
S
Q
P
------------
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
YSGP
A
G
T
G
K
A
A
F
V
A
R
A
R
---
E
-
L
-
A
A
A
Y
------------------
4
PsiBlast_PDB
70.41
33%
-84
- C2 -
4B3H
9
?
A:
[30-724]
---------------
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
KG
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
PDGAGVQP
W
D
K
K
G
Y
K
M
P
------
G
G
T
P
S
S
-
P
G
L
A
A
I
L
P
S
F
P
S
--
N
L
R
K
Q
L
K
G
A
P
M
P
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
A
G
-----
G
S
R
--
P
E
G
--
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
-------
A
A
---
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
------------
L
E
R
--
G
-----
R
T
T
-----
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
-
A
D
-
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
-
G
E
G
-
V
-
E
P
A
S
--
I
E
Q
A
G
S
-
Q
A
-
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
-------
A
T
R
K
G
V
E
-
D
A
G
G
T
Y
Q
P
H
P
A
E
A
V
V
--
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
--
K
R
S
G
----
L
W
P
G
L
R
E
T
F
K
-
S
----------
G
S
S
Q
P
------------
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
YSGP
A
G
T
G
K
A
A
F
V
A
R
A
R
---
E
-
L
-
A
A
A
Y
------------------
25
PsiBlast_CBE
69.78
33%
-83
- C2 -
4B3J
10
?
B:
[30-724]
---------------
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
KG
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
PDGAGVQP
W
D
K
K
G
Y
K
M
P
------
G
G
T
P
S
S
-
P
G
L
A
A
I
L
P
S
F
P
S
--
N
L
R
K
Q
L
K
G
A
P
M
P
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
A
G
-----
G
S
R
--
P
E
G
--
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
-------
A
A
---
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
------------
L
E
R
--
G
-----
R
T
T
-----
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
-
A
D
-
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
-
G
E
G
-
V
-
E
P
A
S
--
I
E
Q
A
G
S
-
Q
A
-
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
-------
A
T
R
K
G
V
E
-
D
A
G
G
T
YQPH
P
A
E
A
V
V
--
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
--
K
R
S
G
----
L
W
P
G
L
R
E
T
F
K
-
S
----------
G
S
S
Q
P
------------
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
YSGP
A
G
T
G
K
A
A
F
V
A
R
A
R
---
E
-
L
-
A
A
A
Y
------------------
5
PsiBlast_PDB
69.34
33%
-83
- C2 -
4B3I
10
?
A:
[30-724]
---------------
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
KG
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
PDGAGVQP
W
D
K
K
G
Y
K
M
P
------
G
G
T
P
S
S
-
P
G
L
A
A
I
L
P
S
F
P
S
--
N
L
R
K
Q
L
K
G
A
P
M
P
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
A
G
-----
G
S
R
--
P
E
G
--
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
-------
A
A
---
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
------------
L
E
R
--
G
-----
R
T
T
-----
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
-
A
D
-
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
-
G
E
G
-
V
-
E
P
A
S
--
I
E
Q
A
G
S
-
Q
A
-
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
-------
A
T
R
K
G
V
E
-
D
A
G
G
T
Y
Q
P
H
P
A
E
A
V
V
--
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
--
K
R
S
G
----
L
W
P
G
L
R
E
T
F
K
-
S
----------
G
S
S
Q
P
------------
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
YSGP
A
G
T
G
K
A
A
F
V
A
R
A
R
---
E
-
L
-
A
A
A
Y
------------------
6
PsiBlast_PDB
69.21
33%
-84
- C2 -
4B3J
10
?
A:
[30-724]
---------------
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
KG
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
PDGAGVQP
W
D
K
K
G
Y
K
M
P
------
G
G
T
P
S
S
-
P
G
L
A
A
I
L
P
S
F
P
S
--
N
L
R
K
Q
L
K
G
A
P
M
P
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
A
G
-----
G
S
R
--
P
E
G
--
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
-------
A
A
---
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
------------
L
E
R
--
G
-----
R
T
T
-----
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
-
A
D
-
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
-
G
E
G
-
V
-
E
P
A
S
--
I
E
Q
A
G
S
-
Q
A
-
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
-------
A
T
R
K
G
V
E
-
D
A
G
G
T
Y
Q
P
H
P
A
E
A
V
V
--
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
--
K
R
S
G
----
L
W
P
G
L
R
E
T
F
K
-
S
----------
G
S
S
Q
P
------------
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
YSGP
A
G
T
G
K
A
A
F
V
A
R
A
R
---
E
-
L
-
A
A
A
Y
------------------
26
PsiBlast_CBE
68.98
33%
-81
- C2 -
4B3I
10
?
B:
[30-724]
---------------
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
KG
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
PDGAGVQP
W
D
K
K
G
Y
K
M
P
------
G
G
T
P
S
S
-
P
G
L
A
A
I
L
P
S
F
P
S
--
N
L
R
K
Q
L
K
G
A
P
M
P
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
A
G
-----
G
S
R
--
P
E
G
--
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
-------
A
A
---
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
------------
L
E
R
--
G
-----
R
T
T
-----
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
-
A
D
-
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
-
G
E
G
-
V
-
E
P
A
S
--
I
E
Q
A
G
S
-
Q
A
-
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
-------
A
T
R
K
G
V
E
-
D
A
G
G
T
Y
Q
P
H
P
A
E
A
V
V
--
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
--
K
R
S
G
----
L
W
P
G
L
R
E
T
F
K
-
S
----------
G
S
S
Q
P
------------
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
YSGP
A
G
T
G
K
A
A
F
V
A
R
A
R
---
E
-
L
-
A
A
A
Y
------------------
113
HHSearch
67.92
32%
-87
- C2 -
2WTB
-
MFP2_ARATH
A:
[8-715]
------
K
T
V
M
E
V
G
G
D
G
V
A
V
I
T
L
I
N
P
P
--
V
N
S
L
S
F
D
V
L
Y
N
L
K
S
N
Y
E
E
A
L
S
R
N
-
D
V
K
A
I
V
I
T
G
A
K
G
R
F
S
G
G
F
D
I
----------
E
P
K
A
G
Y
I
--
S
I
D
I
I
T
D
L
L
E
A
A
R
K
P
S
V
A
A
I
D
G
L
A
L
G
G
G
L
E
L
A
M
A
C
H
A
R
I
S
A
P
A
--
A
Q
L
G
L
P
E
L
Q
L
G
V
I
P
G
F
G
G
T
Q
R
L
P
R
L
V
G
L
T
K
A
-
L
E
M
I
L
T
S
K
P
V
K
A
E
E
G
H
S
L
G
L
I
D
A
V
V
P
P
-
A
E
L
V
T
T
A
R
R
W
A
L
D
I
V
G
R
R
--------
K
P
W
V
S
S
V
S
K
TD----
K
L
P
P
L
---
G
--
E
A
R
E
I
L
T
F
A
K
A
Q
T
L
K
R
-
A
P
N
M
K
H
P
L
M
C
L
D
A
I
E
V
G
I
V
S
G
P
R
A
G
L
E
K
E
A
E
V
A
S
Q
V
V
K
L
D
T
T
K
G
L
I
H
V
F
F
S
Q
-
R
G
T
A
K
V
-----
P
G
V
TD
R
G
L
--
V
P
R
K
-
I
K
K
V
A
I
I
G
G
G
L
M
G
S
G
I
A
T
A
L
I
L
S
N
Y
P
V
I
L
K
E
V
N
E
K
-------
F
L
---
E
A
G
I
G
R
V
K
A
N
L
Q
S
R
------------
V
R
-----------
S
-----
Q
E
K
F
E
K
T
M
S
L
L
K
G
S
L
D
Y
-
E
S
-
F
-
R
D
V
D
M
V
I
E
A
V
I
E
N
I
S
L
K
Q
Q
I
F
A
D
L
E
K
Y
C
P
Q
H
C
I
L
A
S
N
T
S
T
I
D
L
N
K
I
G
E
R
T
K
S
Q
D
R
I
V
G
A
H
F
F
S
P
A
H
I
M
P
L
L
E
I
V
R
T
N
H
T
S
A
Q
V
I
V
D
L
L
D
V
G
K
K
I
K
K
T
P
V
V
V
G
N
C
T
G
F
A
V
N
R
M
F
F
P
Y
T
Q
A
A
M
F
L
V
-
E
C
G
-
A
-
D
P
Y
L
--
I
D
R
A
I
S
-
K
F
-
G
--
M
P
M
G
P
F
R
L
C
D
L
V
G
F
G
V
A
I
A
T
A
T
-------
Q
F
I
E
N
F
S
-
E
R
T
Y
K
----
S
--
M
I
I
--
P
L
M
Q
E
D
K
---------------------------
D
P
E
L
K
K
Y
I
E
K
A
R
S
I
S
GV
K
L
D
P
K
L
A
N
L
------------
S
E
K
D
I
I
E
M
T
F
F
P
V
V
N
E
A
C
R
V
F
A
E
G
I
A
V
K
A
A
D
L
D
I
A
G
I
M
G
M
G
F
P
P
Y
R
G
G
I
M
F
W
A
------
D
S
I
G
S
K
Y
I
Y
S
R
L
D
E
W
S
K
-
A
Y
G
E
F
F
K
P
C
A
F
L
A
E
R
G
S
K
G
V
L
L
S
-
3
PsiBlast_PDB
66.74
32%
-83
- C2 -
2WTB
-
MFP2_ARATH
A:
[28-711]
----------------------------
V
N
S
L
S
F
D
V
L
Y
N
L
K
S
N
Y
E
E
A
L
S
R
N
-
D
V
K
A
I
V
I
T
G
A
K
G
R
F
S
G
G
F
D
I
------------
E
P
K
A
G
Y
I
S
I
D
I
I
T
D
L
L
E
A
A
R
K
P
S
V
A
A
I
D
G
L
A
L
G
G
G
L
E
L
A
M
A
C
H
A
R
I
S
A
P
A
--
A
Q
L
G
L
P
E
L
Q
L
G
V
I
P
G
F
G
G
T
Q
R
L
P
R
L
V
G
L
T
K
A
-
L
E
M
I
L
T
S
K
P
V
K
A
E
E
G
H
S
L
G
L
I
D
A
V
V
P
P
-
A
E
L
V
T
T
A
R
R
W
A
---------------
L
D
I
V
G
R
R
K
P
WVSSVS
K
T
D
K
L
P
P
L
G
E
A
R
E
I
L
T
F
A
K
A
Q
T
L
---
K
R
A
P
N
M
K
H
P
L
M
C
L
D
A
I
E
V
G
I
V
S
G
P
R
A
G
L
E
K
E
A
E
V
A
S
Q
V
V
K
L
D
T
T
K
G
L
I
H
V
F
F
S
Q
-
R
G
T
A
K
V
-----
P
G
V
--
T
D
R
G
L
V
P
R
K
-
I
K
K
V
A
I
I
G
G
G
L
M
G
S
G
I
A
T
A
L
I
L
S
N
Y
P
V
I
L
K
E
V
N
E
K
-------
F
L
---
E
A
G
I
G
R
V
K
A
N
L
Q
S
R
------------
V
R
-----------
S
-----
Q
E
K
F
E
K
T
M
S
L
L
K
G
S
L
D
Y
-
E
S
-
F
-
R
D
V
D
M
V
I
E
A
V
I
E
N
I
S
L
K
Q
Q
I
F
A
D
L
E
K
Y
C
P
Q
H
C
I
L
A
S
N
T
S
T
I
D
L
N
K
I
G
E
R
T
K
S
Q
D
R
I
V
G
A
H
F
F
S
P
A
H
I
M
P
L
L
E
I
V
R
T
N
H
T
S
A
Q
V
I
V
D
L
L
D
V
G
K
K
I
K
K
T
P
V
V
V
G
N
C
T
G
F
A
V
N
R
M
F
F
P
Y
T
Q
A
A
M
F
L
V
-
E
C
G
-
A
-
D
P
Y
L
--
I
D
R
A
I
S
-
K
F
-
G
--
M
P
M
G
P
F
R
L
C
D
L
V
G
F
G
V
A
I
A
T
A
T
-------
Q
F
I
E
N
F
S
-
E
R
--
T
----
Y
K
S
M
I
I
--
P
L
M
Q
E
D
K
---------------------------
D
P
E
----
L
K
-
K
Y
I
-------
E
K
A
R
S
I
S
GV
K
L
D
P
KLANL
S
E
K
D
I
I
E
M
T
F
F
P
V
V
N
E
A
C
R
V
F
A
E
G
I
A
V
K
A
A
D
L
D
I
A
G
I
M
G
M
G
F
P
P
Y
R
G
G
I
M
F
W
A
------
D
S
I
G
S
K
Y
I
Y
S
R
L
D
E
W
S
K
A
Y
-
G
E
F
F
K
P
C
A
F
L
A
E
R
G
S
K
G
-----
11
PsiBlast_PDB
63.15
31%
-78
- C2 -
3ZWC
5
ECHP_RAT
A:
[41-701]
----------------------------
V
N
A
V
S
P
T
V
I
R
E
V
R
N
G
L
Q
K
A
G
S
D
H
-
T
V
K
A
I
V
I
C
G
A
N
G
N
F
C
A
G
A
D
I
H
G
F
---------
S
A
F
T
P
G
L
A
L
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
A
K
--
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
A
V
V
K
S
-
D
P
V
E
E
A
-
I
K
F
A
Q
K
I
I
D
K
P
--------
I
E
--
P
R
R
I
F
------
N
K
P
V
P
S
-
L
P
N
M
D
S
V
F
A
E
A
I
A
K
---
V
R
K
Q
Y
P
G
V
L
A
P
E
T
C
V
R
S
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
-
K
S
A
N
K
W
STPSG
A
S
W
--
K
T
A
--
S
A
Q
P
-
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
----
V
A
V
E
-------
S
D
---
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
------------
L
E
K
E
A
S
-----
R
A
H
-----
Q
N
G
Q
A
S
A
K
P
K
L
R
F
S
S
S
T
-
K
E
-
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
-
E
E
G
-
S
-
K
P
E
D
--
V
D
G
V
L
E
-
E
F
-
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
GLTGP
S
L
P
P
G
T
P
-
V
R
K
R
G
----
N
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
LG
R
I
H
K
P
D
P
W
L
S
T
F
L
S
Q
Y
R
E
-
V
H
H
-------
I
E
Q
R
T
I
------------
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
------
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
---------------------------
31
PsiBlast_CBE
63.00
31%
-77
- C2 -
3ZW9
3
ECHP_RAT
B:
[41-701]
----------------------------
V
N
A
V
S
P
T
V
I
R
E
V
R
N
G
L
Q
K
A
G
S
D
H
-
T
V
K
A
I
V
I
C
G
A
N
G
N
F
C
A
G
A
D
I
H
G
F
---------
S
A
F
T
P
G
L
A
L
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
A
K
--
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
A
V
V
K
S
-
D
P
V
E
E
A
-
I
K
F
A
Q
K
I
I
D
K
P
--------
I
E
--
P
R
R
I
F
------
N
K
P
V
P
S
-
L
P
N
M
D
S
V
F
A
E
A
I
A
K
---
V
R
K
Q
Y
P
G
V
L
A
P
E
T
C
V
R
S
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
-
K
S
A
N
K
W
STPSG
A
S
W
--
K
T
A
--
S
A
Q
P
-
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
----
V
A
V
E
-------
S
D
---
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
------------
L
E
K
E
A
S
-----
R
A
H
-----
Q
N
G
Q
A
S
A
K
P
K
L
R
F
S
S
S
T
-
K
E
-
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
-
E
E
G
-
S
-
K
P
E
D
--
V
D
G
V
L
E
-
E
F
-
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
GLTGP
S
L
P
P
G
T
P
-
V
R
K
R
G
----
N
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
LG
R
I
H
K
P
D
P
W
L
S
T
F
L
S
Q
Y
R
E
-
V
H
H
-------
I
E
Q
R
T
I
------------
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
------
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
---------------------------
28
PsiBlast_CBE
62.63
31%
-76
- C2 -
2X58
5
ECHP_RAT
B:
[26-686]
----------------------------
V
N
A
V
S
P
T
V
I
R
E
V
R
N
G
L
Q
K
A
G
S
D
H
-
T
V
K
A
I
V
I
C
G
A
N
G
N
F
C
A
G
A
D
I
H
G
F
---------
S
A
F
T
P
G
L
A
L
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
A
K
--
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
A
V
V
K
S
-
D
P
V
E
E
A
-
I
K
F
A
Q
K
I
I
D
K
P
--------
I
E
--
P
R
R
I
F
------
N
K
P
V
P
S
-
L
P
N
M
D
S
V
F
A
E
A
I
A
K
---
V
R
K
Q
Y
P
G
V
L
A
P
E
T
C
V
R
S
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
-
K
S
A
N
K
W
STPSG
A
S
W
--
K
T
A
--
S
A
Q
P
-
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
----
V
A
V
E
-------
S
D
---
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
------------
L
E
K
E
A
S
-----
R
A
H
-----
Q
N
G
Q
A
S
A
K
P
K
L
R
F
S
S
S
T
-
K
E
-
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
-
E
E
G
-
S
-
K
P
E
D
--
V
D
G
V
L
E
-
E
F
-
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
GLTGP
S
L
P
P
G
T
P
-
V
R
K
R
G
----
N
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
LG
R
I
H
K
P
D
P
W
L
S
T
F
L
S
Q
Y
R
E
-
V
H
H
-------
I
E
Q
R
T
I
------------
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
------
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
---------------------------
8
PsiBlast_PDB
62.54
31%
-74
- C2 -
3ZW8
5
ECHP_RAT
A:
[41-701]
----------------------------
V
N
A
V
S
P
T
V
I
R
E
V
R
N
G
L
Q
K
A
G
S
D
H
-
T
V
K
A
I
V
I
C
G
A
N
G
N
F
C
A
G
A
D
I
H
G
F
---------
S
A
F
T
P
G
L
A
L
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
A
K
--
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
A
V
V
K
S
-
D
P
V
E
E
A
-
I
K
F
A
Q
K
I
I
D
K
P
--------
I
E
--
P
R
R
I
F
------
N
K
P
V
P
S
-
L
P
N
M
D
S
V
F
A
E
A
I
A
K
---
V
R
K
Q
Y
P
G
V
L
A
P
E
T
C
V
R
S
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
-
K
S
A
N
K
W
STPSG
A
S
W
--
K
T
A
--
S
A
Q
P
-
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
----
V
A
V
E
-------
S
D
---
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
------------
L
E
K
E
A
S
-----
R
A
H
-----
Q
N
G
Q
A
S
A
K
P
K
L
R
F
S
S
S
T
-
K
E
-
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
-
E
E
G
-
S
-
K
P
E
D
--
V
D
G
V
L
E
-
E
F
-
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
GLTGP
S
L
P
P
G
T
P
-
V
R
K
R
G
----
N
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
LG
R
I
H
K
P
D
P
W
L
S
T
F
L
S
Q
Y
R
E
-
V
H
H
-------
I
E
Q
R
T
I
------------
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
------
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
---------------------------
29
PsiBlast_CBE
62.41
31%
-78
- C2 -
3ZWC
4
ECHP_RAT
B:
[41-701]
----------------------------
V
N
A
V
S
P
T
V
I
R
E
V
R
N
G
L
Q
K
A
G
S
D
H
-
T
V
K
A
I
V
I
C
G
A
N
G
N
F
C
A
G
A
D
I
H
G
F
---------
S
A
F
T
P
G
L
A
L
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
A
K
--
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
A
V
V
K
S
-
D
P
V
E
E
A
-
I
K
F
A
Q
K
I
I
D
K
P
--------
I
E
--
P
R
R
I
F
------
N
K
P
V
P
S
-
L
P
N
M
D
S
V
F
A
E
A
I
A
K
---
V
R
K
Q
Y
P
G
V
L
A
P
E
T
C
V
R
S
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
-
K
S
A
N
K
W
STPSG
A
S
W
--
K
T
A
--
S
A
Q
P
-
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
----
V
A
V
E
-------
S
D
---
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
------------
L
E
K
E
A
S
-----
R
A
H
-----
Q
N
G
Q
A
S
A
K
P
K
L
R
F
S
S
S
T
-
K
E
-
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
-
E
E
G
-
S
-
K
P
E
D
--
V
D
G
V
L
E
-
E
F
-
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
GLTGP
S
L
P
P
G
T
P
-
V
R
K
R
G
----
N
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
LG
R
I
H
K
P
D
P
W
L
S
T
F
L
S
Q
Y
R
E
-
V
H
H
-------
I
E
Q
R
T
I
------------
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
------
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
---------------------------
18
PsiBlast_PDB
40.57
39%
-78
- C2 -
4KUG
1
?
A:
[6-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
-------
F
V
---
D
R
G
I
A
T
I
T
K
S
L
S
K
L
------------
V
A
K
--
E
-----
K
I
T
-----
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
-
K
L
-
A
-
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
-
Q
E
G
-
V
-
A
K
E
E
D
-
I
D
A
A
M
--
K
L
-
G
AN
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
-------
V
L
Y
N
E
T
G
-
D
-
T
K
Y
----
R
A
S
S
L
L
--
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
39.18
39%
-74
- C2 -
4KUG
1
?
C:
[6-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
-------
F
V
---
D
R
G
I
A
T
I
T
K
S
L
S
K
L
------------
V
A
K
--
E
-----
K
I
T
-----
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
-
K
L
-
A
-
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
-
Q
E
G
-
V
-
A
K
E
E
D-
I
D
A
A
M
--
K
L
-
G
AN
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
-------
V
L
Y
N
E
T
G
-
D
-
T
K
Y
----
R
A
S
S
L
L
--
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
38.66
39%
-74
- C2 -
4KUG
1
?
D:
[6-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
-------
F
V
---
D
R
G
I
A
T
I
T
K
S
L
S
K
L
------------
V
A
K
--
E
-----
K
I
T
-----
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
-
K
L
-
A
-
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
-
Q
E
G
-
V
-
A
K
E
E
D-
I
D
A
A
M
--
K
L
-
G
AN
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
-------
V
L
Y
N
E
T
G
-
D
-
T
K
Y
----
R
A
S
S
L
L
--
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
37.93
39%
-76
- C2 -
4KUG
1
?
B:
[6-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
-------
F
V
---
D
R
G
I
A
T
I
T
K
S
L
S
K
L
------------
V
A
K
--
E
-----
K
I
T
-----
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
-
K
L
-
A
-
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
-
Q
E
G
-
V
-
A
K
E
E
D-
I
D
A
A
M
--
K
L
-
G
AN
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
-------
V
L
Y
N
E
T
G
-
D
-
T
K
Y
----
R
A
S
S
L
L
--
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
34.99
34%
-66
- C2 -
1F0Y
3
HCDH_HUMAN
A:
[12-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
I
-
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
---
A
K
S
K
K
G
I
E
E
S
L
R
K
V
------------
A
K
K
--
K
-----
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
-
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
-
A
-
S
K
E
D
--
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
E
N
P
L
H
Q
----
P
-
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
105
Fugue
34.78
33%
-64
- C2 -
1IL0
3
HCDH_HUMAN
A:
[12-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
I
-
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
---
A
K
S
K
K
G
I
E
E
S
L
R
K
V
------------
A
K
K
--
K
F
A
EN
P
K
A
G
-----
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
-
A
S
V
V
-
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
-
D
A
S
K
E
D
--
I
D
T
A
M
K
-
L
G
A
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
34.67
35%
-76
- C2 -
3HDH
1
HCDH_PIG
A:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
---
E
E
S
L
R
K
V
A
K
--
K
K
F
------------
A
E
N
--
P
-----
K
A
G
-----
D
E
F
V
E
K
T
L
S
S
I
S
T
S
T
D
A
-
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
-
E
R
G
---
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
I
D
-------
G
W
H
E
M
D
S
-
Q
N
P
L
F
----
Q
P
S
P
A
M
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
34.58
34%
-69
- C2 -
3HAD
1
HCDH_HUMAN
A:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
EN
P
K
A
G
D
E
F
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
---
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
34.28
34%
-69
- C2 -
1LSJ
1
HCDH_HUMAN
A:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
FAEN
P
K
A
G
D
E
F
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
Q
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
D
A
-
S
K
E
D
--
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
34.00
34%
-69
- C2 -
1M75
3
HCDH_HUMAN
B:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
AKS
K
K
G
I
E
E
S
L
R
K
V
A
K
K
KFAENPKAGDEF
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
---
D
A
S
K
ED
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
33.22
34%
-70
- C2 -
1F17
1
HCDH_HUMAN
A:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
KFAEN
P
K
A
G
D
E
C
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
D
A
-
S
K
E
D
--
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
33.17
34%
-67
- C2 -
3HAD
1
HCDH_HUMAN
B:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
AKS
K
K
G
I
E
E
S
L
R
K
V
A
K
K
KFAENPKAGDEF
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
---
D
A
S
K
ED
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
33.01
34%
-66
- C2 -
1F17
1
HCDH_HUMAN
B:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
AKS
K
K
G
I
E
E
S
L
R
K
V
A
K
K
KFAENPKAGDEC
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
D
A
-
S
K
E
D
--
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
32.99
34%
-63
- C2 -
1F0Y
3
HCDH_HUMAN
A:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
FAEN
P
K
A
G
D
E
F
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
D
A
-
S
K
E
D
--
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
32.90
34%
-65
- C2 -
1F0Y
3
HCDH_HUMAN
B:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
AKS
K
K
G
I
E
E
S
L
R
K
V
A
K
K
KFAENPKAGDEF
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
D
A
-
S
K
E
D
--
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
32.86
35%
-69
- C2 -
3HDH
1
HCDH_PIG
B:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
ILAKSKK
G
I
---
E
E
S
L
R
K
V
A
K
--
K
K
F
------------
A
E
N
--
P
-----
K
A
G
-----
D
E
F
V
E
K
T
L
S
S
I
S
T
S
T
D
A
-
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
-
E
R
G
---
D
A
S
K
ED
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
I
D
-------
G
W
H
E
M
D
S
-
Q
N
P
L
F
----
Q
P
S
P
A
M
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
32.77
34%
-61
- C2 -
1IL0
3
HCDH_HUMAN
B:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
AKS
K
K
G
I
E
E
S
L
R
K
V
A
K
K
KFAENPKAGDEF
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
D
A
-
S
K
E
D
--
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
32.65
34%
-69
- C2 -
1F12
1
HCDH_HUMAN
A:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
FAEN
P
K
A
G
D
E
C
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
D
A
-
S
K
E
D
--
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
32.52
34%
-64
- C2 -
1M76
3
HCDH_HUMAN
B:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
AKS
K
K
G
I
E
E
S
L
R
K
V
A
K
K
KFAENPKAGDEF
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
C
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
D
A
-
S
K
E
D
--
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
32.52
34%
-65
- C2 -
1LSJ
1
HCDH_HUMAN
B:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
AKS
K
K
G
I
E
E
S
L
R
K
V
A
K
K
KFAENPKAGDEF
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
Q
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
D
A
-
S
K
E
D
--
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
32.28
34%
-61
- C2 -
1M76
3
HCDH_HUMAN
A:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
FAEN
P
K
A
G
D
E
F
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
C
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
D
A
-
S
K
E
D
--
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
32.15
34%
-68
- C2 -
1LSO
1
HCDH_HUMAN
A:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
AEN
P
K
A
G
D
E
F
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
A
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
D
A
-
S
K
E
D
--
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
32.00
34%
-64
- C2 -
1M75
3
HCDH_HUMAN
A:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
KFAEN
P
K
A
G
D
E
F
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
---
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
31.93
34%
-63
- C2 -
1IL0
3
HCDH_HUMAN
A:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
EN
P
K
A
G
D
E
F
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
D
A
-
S
K
E
D
--
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
31.24
34%
-68
- C2 -
1LSO
1
HCDH_HUMAN
B:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
-------
I
L
AKS
K
K
G
I
E
E
S
L
R
K
V
A
K
K
KFAENPKAGDEF
V
E
K
--
T
-----
L
S
T
-----
I
A
T
S
T
D
A
A
S
V
V
H
S
T
------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
A
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
-
E
R
G
D
A
-
S
K
E
D
--
I
D
T
A
M
K
L
G
A
-
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
-------
G
W
H
E
M
D
A
-
E
N
P
L
H
----
Q
P
S
P
S
L
--
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------