@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3107: (2016-02-13 )
MTQDWDAGRLDSDLEGAAFDTLAVRAGQRRTPEGEHGEALFTTSSYVFRTAADAAARFAGEVPGNVYSRYTNPTVRTFEERIAALEGAEQAVATASGMSAILALVMSLCSSGDHVLVSRSVFGSTISLFDKYFKRFGIQVDYPPLSDLAAWEAACKPNTKLFFVESPSNPLAELVDIAALAEIAHAKGALLAVDNCFCTPALQQPLKLGADVVIHSATKYIDGQGRGMGGVVAGRGEQMKEVVGFLRTAGPTLSPFNAWLFLKGLETLRIRMQAHSASALALAEWLERQPGIERVYYAGLPSHPQHELARRQQSGFGAVVSFDVKGGRDAAWRFIDATRMVSITTNLGDTKTTIAHPATTSHGRLSPEDRARAGIGDSLIRVAVGLEDLDDLKADMARGLAAL
Atome Classification :
(28 SA)
.........10........20........30.-.-......40---.........50........60........70........80........90........100.......110.......120.......130....-...140....-...150.......160.......170.......180....-.-..190.......200........210.......220-..-.....230........-240----.--------------------------.--.--.....-250.......260.......270.......280.......290.......300.......310..-.....320.......330.......340.......350--........360.......370.......380.......390.......400.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTQDWDAGRLDSDLEGAA
F
D
T
L
A
VRAGQRRTP-E-GEHG
E
A
L
----
F
TTS
S
Y
V
F
R
T
A
A
D
A
A
A
R
F
A
GEVPG
N
V
Y
S
RYTNP
T
V
R
T
F
E
E
R
I
A
A
LEG
A
E
Q
A
V
A
TAS
G
M
S
A
I
L
A
L
V
M
S
L
CSSG
D
H
V
L
V
SRSVFG
S
T
I
S
L
F
D
K
Y
F
K
RF-G
I
Q
VDYPP
L
S
-
D
L
A
A
W
E
AACKPN
T
K
L
F
F
V
ESPSN
P
L
A
E
L
V
D
I
A
A
L
A
E
I
A
HA-K-G
A
L
L
A
VDNCFC
T
P
-
A
L
Q
Q
P
L
K
LGA
D
V
V
I
HSATKYID-GQ-GRGMGGV-VAGR
G
E
Q
M
-
K
E
-----
V
--------------------------
V
--
G
--
F
L
R
TA-GPTL
S
P
F
N
A
W
L
F
L
KG
L
E
T
L
R
I
R
M
QAHS
A
S
A
L
A
L
A
E
W
L
E
RQPGI
E
R
V
Y
YAGLPSH
P
Q
H
E
L
A
R
R
Q
QS-GF
G
A
V
V
S
F
DVKGGR
D
A
A
W
R
F
I
D
A
T
R
M
V
S
I
T
TNLGDTK---
T
T
I
AHPATTSHGRL
S
P
E
D
R
A
RAGI
G
D
S
L
I
R
V
A
VG
L
E
D
L
D
D
L
K
A
D
M
A
R
GLAAL
5
PsiBlast_PDB
92.62
44%
-97
- C1 -
3JWA
6
?
A:
[2-393]
-----------
S
D
C
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
----
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
A
L
E
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
-
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
-
D
Q
AR---
F
--------------------------
V
--
G
--
L
K
D
I
T
-
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
---
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
---
3
PsiBlast_PDB
92.44
44%
-99
- C1 -
4HF8
5
?
A:
[2-393]
-----------
S
D
C
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
----
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
A
L
E
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
-
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
-
D
Q
-----
A
RF------------------------
V
--
G
--
L
K
D
I
T
-
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
---
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
---
1
PsiBlast_PDB
92.28
44%
-100
- C1 -
4OMA
6
?
A:
[2-393]
-----------
S
D
C
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
----
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
A
L
E
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
-
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
-
D
Q
-----
A
R
F
------------------------
V
--
G
--
L
K
D
I
T
-
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
---
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
---
4
PsiBlast_PDB
92.00
44%
-98
- C1 -
3JW9
2
?
A:
[2-393]
-----------
S
D
C
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
----
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
A
L
E
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
-
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
-
D
Q
A
R---
F
--------------------------
V
--
G
--
L
K
D
I
T
-
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
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A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
---
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
---
107
HHSearch
91.95
44%
-100
- C1 -
2RFV
1
?
A:
[2-396]
-----------
S
D
C
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
-
G
A
L
S
T
P
I
----
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
-----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
-
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
-
D
Q
-----
A
--------------------------
R
FV
G
--
L
K
D
I
T
-
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
---
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
6
PsiBlast_PDB
91.50
44%
-98
- C1 -
3JWB
4
?
A:
[2-393]
-----------
S
D
C
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
----
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
A
L
E
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
-
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
-
D
Q
AR---
F
--------------------------
V
--
G
--
L
K
D
I
T
-
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
---
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
---
7
PsiBlast_PDB
90.44
44%
-99
- C1 -
2RFV
1
?
A:
[2-393]
-----------
S
D
C
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
----
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
-----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
-
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
-
D
Q
AR---
F
--------------------------
V
--
G
--
L
K
D
I
T
-
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
---
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
---
2
PsiBlast_PDB
89.56
44%
-102
- C1 -
3MKJ
1
?
A:
[2-393]
-----------
S
D
C
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
----
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
-----------
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
-
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
-
D
Q
AR---
F
--------------------------
V
--
G
--
L
K
D
I
T
-
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
---
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
---
9
PsiBlast_PDB
89.45
44%
-97
- C1 -
1Y4I
1
?
A:
[2-393]
-----------
S
D
C
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
----
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
A
L
E
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
R
F
V
D
A
G
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
-
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
-
D
Q
A
R---
F
--------------------------
V
--
G
--
L
K
D
I
T
-
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
---
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
---
41
PsiBlast_CBE
88.88
42%
-92
- C1 -
2O7C
1
MEGL_PSEPU
C:
[10-396]
---------------------
F
A
T
R
A
I
H
H
G
Y
D
-
P
-
Q
D
H
G
G
A
L
VPPV
Y
Q
T
A
T
F
T
F
P
T
V
E
Y
G
A
A
C
F
A
G
E
Q
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
Q
A
L
E
A
A
M
T
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
-
H
-
G
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
-
G
D
I
T
A
G
I
-
V
V
G
S
Q
A
L
V
-
D
R
-----
I
RL------------------------
Q
--
G
--
L
K
D
M
T
-
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
M
S
-
Q
P
G
G
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
---
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
A
-
11
PsiBlast_PDB
88.88
42%
-93
- C1 -
1PG8
9
MEGL_PSEPU
A:
[10-396]
---------------------
F
A
T
R
A
I
H
H
G
Y
D
-
P
-
Q
D
H
G
G
A
L
VPPV
Y
Q
T
A
T
F
T
F
P
T
V
E
Y
G
A
A
C
F
A
G
E
Q
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
Q
A
L
E
A
A
M
T
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
-
H
-
G
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
-
G
D
I
T
A
G
I
-
V
V
G
S
Q
A
L
V
-
D
R
-----
I
R
L
------------------------
Q
--
G
--
L
K
D
M
T
-
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
M
S
-
Q
P
G
G
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
---
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
A
-
24
PsiBlast_CBE
88.14
44%
-97
- C1 -
4IY7
5
?
D:
[19-393]
--------------------
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
----
Y
A
T
S
T
Y
--------
A
Q
S
S
P
G
E
H
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
-
S
T
V
M
E
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
-
H
-
G
L
L
T
V
V
D
N
T
F
A
S
P
-
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
-
G
H
-
S
D
M
V
G
G
I
A
V
V
G
D
N
A
E
L
-
A
E
-----
Q
--------------------------
M
--
A
--
F
L
Q
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
-
G
F
G
G
I
V
S
I
V
L
K
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
---
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---
38
PsiBlast_CBE
88.07
42%
-95
- C1 -
3VK2
1
MEGL_PSEPU
C:
[10-396]
---------------------
F
A
T
R
A
I
H
H
G
Y
D
-
P
-
Q
D
H
G
G
A
L
VPPV
Y
Q
T
A
T
F
T
F
P
T
V
E
Y
G
A
A
C
F
A
G
E
Q
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
H
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
Q
A
L
E
A
A
M
T
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
-
H
-
G
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
-
G
D
I
T
A
G
I
-
V
V
G
S
Q
A
L
V
-
D
R
-----
I
R
L------------------------
Q
--
G
--
L
K
D
M
T
-
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
M
S
-
Q
P
G
G
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
---
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
A
-
42
PsiBlast_CBE
87.98
42%
-94
- C1 -
2O7C
1
MEGL_PSEPU
B:
[10-396]
---------------------
F
A
T
R
A
I
H
H
G
Y
D
-
P
-
Q
D
H
G
G
A
L
VPPV
Y
Q
T
A
T
F
T
F
P
T
V
E
Y
G
A
A
C
F
A
G
E
Q
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
Q
A
L
E
A
A
M
T
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
-
H
-
G
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
-
G
D
I
T
A
G
I
-
V
V
G
S
Q
A
L
V
-
D
R
-----
I
RL------------------------
Q
--
G
--
L
K
D
M
T
-
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
M
S
-
Q
P
G
G
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
---
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
A
-
45
PsiBlast_CBE
87.80
42%
-95
- C1 -
1UKJ
2
MEGL_PSEPU
B:
[10-396]
---------------------
F
A
T
R
A
I
H
H
G
Y
D
-
P
-
Q
D
H
G
G
A
L
VPPV
Y
Q
T
A
T
F
T
F
P
T
V
E
Y
G
A
A
C
F
A
G
E
Q
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
Q
A
L
E
A
A
M
T
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
-
H
-
G
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
-
G
D
I
T
A
G
I
-
V
V
G
S
Q
A
L
V
-
D
R
-----
I
RL------------------------
Q
--
G
--
L
K
D
M
T
-
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
M
S
-
Q
P
G
G
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
---
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
A
-
20
PsiBlast_PDB
87.72
44%
-98
- C1 -
4IYO
8
?
A:
[19-393]
--------------------
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
----
Y
A
T
S
T
Y
--------
A
Q
S
S
P
G
E
H
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
-
S
T
V
M
E
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
-
H
-
G
L
L
T
V
V
D
N
T
F
A
S
P
-
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
-
G
H
-
S
D
M
V
G
G
I
A
V
V
G
D
N
A
E
L
-
A
E
-----
Q
--------------------------
M
--
A
--
F
L
Q
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
-
G
F
G
G
I
V
S
I
V
L
K
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
---
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---
35
PsiBlast_CBE
87.67
42%
-95
- C1 -
3VK3
1
MEGL_PSEPU
C:
[10-396]
---------------------
F
A
T
R
A
I
H
H
G
Y
D
-
P
-
Q
D
H
G
G
A
L
VPPV
Y
Q
T
A
T
F
T
F
P
T
V
E
Y
G
A
A
C
F
A
G
E
Q
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
H
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
Q
A
L
E
A
A
M
T
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
-
H
-
G
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
-
G
D
I
T
A
G
I
-
V
V
G
S
Q
A
L
V
-
D
R
-----
I
RL------------------------
Q
--
G
--
L
K
D
M
T
-
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
M
S
-
Q
P
G
G
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
---
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
A
-
22
PsiBlast_CBE
87.64
42%
-93
- C1 -
1PG8
5
MEGL_PSEPU
C:
[10-396]
---------------------
F
A
T
R
A
I
H
H
G
Y
D
-
P
-
Q
D
H
G
G
A
L
VPPV
Y
Q
T
A
T
F
T
F
P
T
V
E
Y
G
A
A
C
F
A
G
E
Q
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
Q
A
L
E
A
A
M
T
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
-
H
-
G
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
-
G
D
I
T
A
G
I
-
V
V
G
S
Q
A
L
V
-
D
R
-----
I
RL------------------------
Q
--
G
--
L
K
D
M
T
-
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
M
S
-
Q
P
G
G
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
---
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
A
-
40
PsiBlast_CBE
87.59
42%
-93
- C1 -
2O7C
1
MEGL_PSEPU
D:
[10-396]
---------------------
F
A
T
R
A
I
H
H
G
Y
D
-
P
-
Q
D
H
G
G
A
L
VPPV
Y
Q
T
A
T
F
T
F
P
T
V
E
Y
G
A
A
C
F
A
G
E
Q
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
Q
A
L
E
A
A
M
T
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
-
H
-
G
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
-
G
D
I
T
A
G
I
-
V
V
G
S
Q
A
L
V
-
D
R
-----
I
RL------------------------
Q
--
G
--
L
K
D
M
T
-
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
M
S
-
Q
P
G
G
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
---
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
A
-
25
PsiBlast_CBE
87.43
44%
-98
- C1 -
4IY7
4
?
C:
[19-393]
--------------------
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
----
Y
A
T
S
T
Y
--------
A
Q
S
S
P
G
E
H
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
-
S
T
V
M
E
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
-
H
-
G
L
L
T
V
V
D
N
T
F
A
S
P
-
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
-
G
H
-
S
D
M
V
G
G
I
A
V
V
G
D
N
A
E
L
-
A
E
-----
Q
--------------------------
M
--
A
--
F
L
Q
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
-
G
F
G
G
I
V
S
I
V
L
K
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
---
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---
105
HHSearch
85.29
37%
-100
- C1 -
1E5E
5
?
A:
[4-395]
--------------
E
R
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
Q
-
F
-
G
A
A
I
P
P
I
----
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
Q
E
-
G
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
-
D
V
V
-
A
G
L
-
I
C
G
K
A
D
L
L
-
Q
Q
-----
I
--------------------------
R
--
M
VG
I
K
D
I
T
-
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
-
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
---
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
27
PsiBlast_CBE
85.03
37%
-96
- C1 -
1E5F
5
?
B:
[10-395]
--------------------
T
A
C
I
H
A
N
P
Q
K
D
Q
-
F
-
G
A
A
I
P
P
I
----
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
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T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
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Y
F
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T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
-
Q
E
G
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
H
-
T
D
V
V
A
G
L
-
I
C
G
K
A
D
L
L
-
Q
Q
-----
I
RM------------------------
V
--
G
--
I
K
D
I
T
-
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
-
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
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A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
---
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
29
PsiBlast_CBE
84.50
37%
-97
- C1 -
1E5E
6
?
B:
[10-395]
--------------------
T
A
C
I
H
A
N
P
Q
K
D
Q
-
F
-
G
A
A
I
P
P
I
----
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
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C
L
Y
G
C
T
H
A
L
F
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H
A
L
T
K
F
-
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I
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V
D
F
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T
A
-
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P
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E
V
K
K
H
M
K
P
N
T
K
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Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
-
Q
E
G
V
L
V
I
A
D
N
T
F
C
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-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
H
-
T
D
V
V
A
G
L
-
I
C
G
K
A
D
L
L
-
Q
Q
-----
I
RM------------------------
V
--
G
--
I
K
D
I
T
-
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
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T
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M
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A
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S
E
N
A
M
K
V
A
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L
K
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A
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V
Y
Y
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G
F
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H
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G
H
D
I
A
K
K
Q
M
R
-
M
Y
G
S
M
I
T
F
I
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K
S
G
F
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A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
---
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
108
HHSearch
84.45
40%
-92
- C1 -
2CTZ
1
?
A:
[2-421]
-----------------
R
F
E
T
L
Q
L
H
A
G
Y
E
P
E
P
T
T
-
L
S
R
Q
V
P
I
----
Y
P
T
T
S
Y
V
F
K
S
P
E
H
A
A
N
L
F
A
L
K
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S
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I
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P
T
V
D
V
L
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R
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A
A
L
E
G
G
K
A
A
L
A
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A
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H
A
A
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L
A
L
T
T
L
A
Q
A
G
D
N
I
V
S
T
P
N
L
Y
G
G
T
F
N
Q
F
K
V
T
L
K
R
L
-
G
I
E
V
R
F
T
S
R
E
E
R
P
E
E
F
L
A
L
T
D
E
K
T
R
A
W
W
V
E
S
I
G
N
P
A
L
N
I
P
D
L
E
A
L
A
Q
A
A
R
E
-
K
-
G
V
A
L
I
V
D
N
T
F
G
M
G
G
Y
L
L
R
P
L
A
W
G
A
A
L
V
T
H
S
L
T
K
W
V
G
-
G
H
-
G
A
V
I
A
G
A
-
I
V
D
G
G
N
F
P
W
E
G
GRYPL
L
TEPQPGYHGLRLTEAFGEL
A
F
I
V
K
A
R
V
--
D
--
G
L
R
D
Q
-
G
Q
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
L
L
E
Q
P
Q
V
A
W
V
N
Y
P
G
L
P
H
H
P
H
H
D
R
A
Q
K
Y
F
K
G
K
P
G
A
V
L
T
F
G
L
K
G
G
Y
E
A
A
K
R
F
I
S
R
L
K
L
I
S
H
L
A
N
V
G
D
T
R
---
T
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
Q
A
G
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
A
--
30
PsiBlast_CBE
84.10
37%
-97
- C1 -
1E5E
5
?
A:
[10-395]
--------------------
T
A
C
I
H
A
N
P
Q
K
D
Q
-
F
-
G
A
A
I
P
P
I
----
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
-
Q
E
G
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
H
-
T
D
V
V
A
G
L
-
I
C
G
K
A
D
L
L
-
Q
Q
-----
I
R
M
------------------------
V
--
G
--
I
K
D
I
T
-
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
-
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
---
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
28
PsiBlast_CBE
84.03
37%
-96
- C1 -
1E5F
6
?
A:
[10-395]
--------------------
T
A
C
I
H
A
N
P
Q
K
D
Q
-
F
-
G
A
A
I
P
P
I
----
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
-
Q
E
G
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
H
-
T
D
V
V
A
G
L
-
I
C
G
K
A
D
L
L
-
Q
Q
-----
I
R
M
------------------------
V
--
G
--
I
K
D
I
T
-
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
-
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
---
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
109
HHSearch
78.55
35%
-95
- C1 -
1IBJ
4
METC_ARATH
A:
[85-462]
----------------
A
S
V
S
T
L
L
V
N
L
D
N
K
F
D
P
-
F
-
D
A
M
S
T
P
L
----
Y
Q
T
A
T
F
K
Q
P
S
A
I
--------
E
N
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
A
V
T
-
H
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
-
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
H
A
-
Q
-
G
A
L
V
L
V
D
N
S
I
M
S
P
-
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
-
G
H
S
D
V
M
-
A
G
V
-
L
A
V
K
G
E
K
L
-
A
K
E
----
V
--------------------------
Y
--
F
--
L
Q
N
S
E
-
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
K
-
G
A
G
S
V
F
S
F
I
T
G
S
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
---
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
T
F
115
HHSearch
74.51
36%
-107
* C1 *
1PFF
18
?
A:
[2-330]
----------------------------------------------------------------------------------
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
A
S
V
W
T
F
L
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
F
-
G
V
E
V
D
F
I
D
M
A
-
V
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
R
K
Q
K
-
D
I
L
V
I
V
D
N
T
F
A
S
P
-
I
L
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
-
D
V
V
A
-
G
L
-
V
C
S
R
A
D
I
I
-
A
K
-----
V
--------------------------
K
--
S
QG
I
K
D
I
T
-
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
P
G
L
P
D
H
P
G
H
E
I
A
K
K
Q
M
K
-
M
F
G
S
M
I
A
F
D
V
D
G
L
----
E
K
A
K
K
V
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
L
V