@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3117: (2016-02-14 )
MKRVGLIGWRGMVGSVLMQRMLEERDFDLIEPVFFTTSNVGGQGPEVGKDIAPLKDAYSIDELKTLDVILTCQGGDYTSEVFPKLREAGWQGYWIDAASSLRMEDDAVIVLDPVNRKVIDQALDAGTRNYIGGNCTVSLMLMALGGLFDAGLVEWMSAMTYQAASGAGAQNMRELLKQMGAAHASVADDLANPASAILDIDRKVAETLRSEAFPTEHFGAPLGGSLIPWIDKELPNGQSREEWKAQAETNKILARFKNPIPVDGICVRVGAMRCHSQALTIKLNKDVPLTDIEGLISQHNPWVKLVPNHREVSVRELTPAAVTGTLSVPVGRLRKLNMGSQYLGAFTVGDQLLWGAAEPLRRMLRILLER
Atome Classification :
(25 SA)
.........10........20........30........40.......-.50...--.....60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230...-....240.......250...--....--260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKRVGLIGW
R
G
M
V
G
S
V
L
M
Q
R
M
L
E
ERDFDLIE
P
V
F
F
TTSNVGGQGPEVG-KDIAPL--KDAYSIDE
L
K
T
L
D
V
I
L
T
CQGGD
Y
T
S
E
V
F
P
K
L
R
E
AGWQ
G
Y
W
IDAASSLRMED
D
A
V
I
V
LDPV
N
R
K
V
I
D
Q
A
L
DAGTRNYIGG
N
C
T
V
S
L
M
L
M
A
L
G
G
L
F
D
A
G
L
V
E
W
M
S
A
M
T
YQAASGA
G
A
Q
N
M
R
E
L
L
K
Q
MGAA
H
A
S
V
A
D
D
LA
N
P
A
S
A
I
L
D
I
D
R
K
V
A
E
T
L
R
SEAFPTEHFGAPLGGSL
I
P
W
I
DKELP-NGQ
S
R
E
E
W
K
A
Q
A
E
T
N
K
I
L
A
R
--FKNP--IPVD
G
I
C
V
RVGAMRCHS
Q
A
L
T
I
K
LNKDVP
L
T
D
I
E
G
L
I
S
QHNP
W
V
K
LVPNHR
E
V
S
V
R
ELTPAA
V
T
G
T
L
SV
P
V
G
R
L
R
KLNMGS
Q
Y
L
G
A
F
TVG
D
Q
L
L
WG
A
A
E
P
L
R
R
M
L
R
I
L
LER
1
PsiBlast_PDB
98.08
100%
-113
- C4 -
5BNT
1
DHAS_PSEAE
C:
[9-378]
M
K
R
V
G
L
I
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
L
E
E
R
D
F
D
L
I
E
P
V
F
F
T
T
S
N
V
G
G
Q
G
P
E
V
G
-
K
D
I
A
P
L
--
K
D
A
Y
S
I
D
E
L
K
T
L
D
V
I
L
T
C
Q
G
G
D
Y
T
S
E
V
F
P
K
L
R
E
A
G
W
Q
G
Y
W
I
D
A
A
S
S
L
R
M
E
D
D
A
V
I
V
L
D
P
V
N
R
K
V
I
D
Q
A
L
D
A
G
T
R
N
Y
I
G
G
N
C
T
V
S
L
M
L
M
A
L
G
G
L
F
D
A
G
L
V
E
W
M
S
A
M
T
Y
Q
A
A
S
G
A
G
A
Q
N
M
R
E
L
L
K
Q
M
G
A
A
H
A
S
V
A
D
D
L
A
N
P
A
S
A
I
L
D
I
D
R
K
V
A
E
T
L
R
S
E
A
F
P
T
E
H
F
G
A
P
L
G
G
S
L
I
P
W
I
D
K
E
L
P
-
N
G
Q
S
R
E
E
W
K
A
Q
A
E
T
N
K
I
L
A
R
--
F
K
N
P
--
I
P
V
D
G
I
C
V
R
V
G
A
M
R
C
H
S
Q
A
L
T
I
K
L
N
K
D
V
P
L
T
D
I
E
G
L
I
S
Q
H
N
P
W
V
K
L
V
P
N
H
R
E
V
S
V
R
E
L
T
P
A
A
V
T
G
T
L
S
V
P
V
G
R
L
R
K
L
N
M
G
S
Q
Y
L
G
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
M
L
R
I
L
L
E
R
22
PsiBlast_CBE
97.72
100%
-111
- C4 -
5BNT
1
DHAS_PSEAE
B:
[9-378]
M
K
R
V
G
L
I
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
L
E
E
R
D
F
D
L
I
E
P
V
F
F
T
T
S
N
V
G
G
Q
G
P
E
V
G
-
K
D
I
A
P
L
--
K
D
A
Y
S
I
D
E
L
K
T
L
D
V
I
L
T
C
Q
G
G
D
Y
T
S
E
V
F
P
K
L
R
E
A
G
W
Q
G
Y
W
I
D
A
A
S
S
L
R
M
E
D
D
A
V
I
V
L
D
P
V
N
R
K
V
I
D
Q
A
L
D
A
G
T
R
N
Y
I
G
G
N
C
T
V
S
L
M
L
M
A
L
G
G
L
F
D
A
G
L
V
E
W
M
S
A
M
T
Y
Q
A
A
S
G
A
G
A
Q
N
M
R
E
L
L
K
Q
M
G
A
A
H
A
S
V
A
D
D
L
A
N
P
A
S
A
I
L
D
I
D
R
K
V
A
E
T
L
R
S
E
A
F
P
T
E
H
F
G
A
P
L
G
G
S
L
I
P
W
I
D
K
E
L
P
-
N
G
Q
S
R
E
E
W
K
A
Q
A
E
T
N
K
I
L
A
R
--
F
K
N
P
--
I
P
V
D
G
I
C
V
R
V
G
A
M
R
C
H
S
Q
A
L
T
I
K
L
N
K
D
V
P
L
T
D
I
E
G
L
I
S
Q
H
N
P
W
V
K
L
V
P
N
H
R
E
V
S
V
R
E
L
T
P
A
A
V
T
G
T
L
S
V
P
V
G
R
L
R
K
L
N
M
G
S
Q
Y
L
G
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
M
L
R
I
L
L
E
R
21
PsiBlast_CBE
97.46
100%
-112
- C4 -
5BNT
1
DHAS_PSEAE
D:
[9-378]
M
K
R
V
G
L
I
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
L
E
E
R
D
F
D
L
I
E
P
V
F
F
T
T
S
N
V
G
G
Q
G
P
E
V
G
-
K
D
I
A
P
L
--
K
D
A
Y
S
I
D
E
L
K
T
L
D
V
I
L
T
C
Q
G
G
D
Y
T
S
E
V
F
P
K
L
R
E
A
G
W
Q
G
Y
W
I
D
A
A
S
S
L
R
M
E
D
D
A
V
I
V
L
D
P
V
N
R
K
V
I
D
Q
A
L
D
A
G
T
R
N
Y
I
G
G
N
C
T
V
S
L
M
L
M
A
L
G
G
L
F
D
A
G
L
V
E
W
M
S
A
M
T
Y
Q
A
A
S
G
A
G
A
Q
N
M
R
E
L
L
K
Q
M
G
A
A
H
A
S
V
A
D
D
L
A
N
P
A
S
A
I
L
D
I
D
R
K
V
A
E
T
L
R
S
E
A
F
P
T
E
H
F
G
A
P
L
G
G
S
L
I
P
W
I
D
K
E
L
P
-
N
G
Q
S
R
E
E
W
K
A
Q
A
E
T
N
K
I
L
A
R
--
F
K
N
P
--
I
P
V
D
G
I
C
V
R
V
G
A
M
R
C
H
S
Q
A
L
T
I
K
L
N
K
D
V
P
L
T
D
I
E
G
L
I
S
Q
H
N
P
W
V
K
L
V
P
N
H
R
E
V
S
V
R
E
L
T
P
A
A
V
T
G
T
L
S
V
P
V
G
R
L
R
K
L
N
M
G
S
Q
Y
L
G
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
M
L
R
I
L
L
E
R
23
PsiBlast_CBE
96.91
100%
-108
- C4 -
5BNT
1
DHAS_PSEAE
A:
[10-377]
-
K
R
V
G
L
I
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
L
E
E
R
D
F
D
L
I
E
P
V
F
F
T
T
S
N
V
G
G
Q
G
P
E
V
G
-
K
D
I
A
P
L
--
K
D
A
Y
S
I
D
E
L
K
T
L
D
V
I
L
T
C
Q
G
G
D
Y
T
S
E
V
F
P
K
L
R
E
A
G
W
Q
G
Y
W
I
D
A
A
S
S
L
R
M
E
D
D
A
V
I
V
L
D
P
V
N
R
K
V
I
D
Q
A
L
D
A
G
T
R
N
Y
I
G
G
N
C
T
V
S
L
M
L
M
A
L
G
G
L
F
D
A
G
L
V
E
W
M
S
A
M
T
Y
Q
A
A
S
G
A
G
A
Q
N
M
R
E
L
L
K
Q
M
G
A
A
H
A
S
V
A
D
D
L
A
N
P
A
S
A
I
L
D
I
D
R
K
V
A
E
T
L
R
S
E
A
F
P
T
E
H
F
G
A
P
L
G
G
S
L
I
P
W
I
D
K
E
L
P
-
N
G
Q
S
R
E
E
W
K
A
Q
A
E
T
N
K
I
L
A
R
--
F
K
N
P
--
I
P
V
D
G
I
C
V
R
V
G
A
M
R
C
H
S
Q
A
L
T
I
K
L
N
K
D
V
P
L
T
D
I
E
G
L
I
S
Q
H
N
P
W
V
K
L
V
P
N
H
R
E
V
S
V
R
E
L
T
P
A
A
V
T
G
T
L
S
V
P
V
G
R
L
R
K
L
N
M
G
S
Q
Y
L
G
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
M
L
R
I
L
L
E
-
24
PsiBlast_CBE
90.46
73%
-112
- C4 -
3UW3
1
?
B:
[7-377]
---
V
G
L
V
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
Q
E
E
G
D
F
D
L
I
E
P
V
F
F
S
T
S
N
A
G
G
K
A
P
S
F
A
-
K
N
E
T
T
L
--
K
D
A
T
S
I
D
D
L
K
K
C
D
V
I
I
T
C
Q
G
G
D
Y
T
N
D
V
F
P
K
L
R
A
A
G
W
N
G
Y
W
I
D
A
A
S
S
L
R
M
K
D
D
A
V
I
I
L
D
P
V
N
L
N
V
I
K
D
A
L
V
N
G
T
K
N
F
I
G
G
N
C
T
V
S
L
M
L
M
A
L
G
G
L
F
R
E
N
L
V
D
W
M
T
A
M
T
Y
Q
A
A
S
G
A
G
A
Q
N
M
R
E
L
L
A
Q
M
G
T
L
N
G
A
V
A
A
Q
L
A
D
P
A
S
A
I
L
D
I
D
R
R
V
L
A
A
M
N
G
D
A
M
P
T
S
Q
F
G
V
P
L
A
G
S
L
I
P
W
I
D
K
D
L
G
-
N
G
M
S
R
E
E
W
K
G
G
A
E
T
N
K
I
L
G
K
PA
M
G
E
P
GS
V
P
V
D
G
L
C
V
R
I
G
A
M
R
C
H
S
Q
A
L
T
I
K
L
K
K
D
V
P
L
D
E
I
N
G
I
L
A
S
A
N
D
W
V
K
V
V
P
N
E
R
E
A
S
M
R
D
L
S
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
L
A
M
G
G
E
Y
L
S
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
M
L
R
I
L
L
D
K
17
PsiBlast_PDB
89.49
66%
-110
- C4 -
1PQU
3
DHAS_HAEIN
A:
[1-370]
M
K
N
V
G
F
I
G
W
R
G
M
V
G
S
V
L
M
D
R
M
S
Q
E
N
D
F
E
N
L
N
P
V
F
F
T
T
S
Q
A
G
Q
K
A
P
V
F
G
G
K
D
A
G
D
L
--
K
S
A
F
D
I
E
E
L
K
K
L
D
I
I
V
T
C
Q
G
G
D
Y
T
N
E
V
Y
P
K
L
K
A
T
G
W
D
G
Y
W
V
D
A
A
S
A
L
R
M
K
D
D
A
I
I
V
L
D
P
V
N
Q
H
V
I
S
E
G
L
K
K
G
I
K
T
F
V
G
G
N
C
T
V
S
L
M
L
M
A
I
G
G
L
F
E
K
D
L
V
E
W
I
S
V
A
T
Y
Q
A
A
S
G
A
G
A
K
N
M
R
E
L
L
S
Q
M
G
L
L
E
Q
A
V
S
S
E
L
K
D
P
A
S
S
I
L
D
I
E
R
K
V
T
A
K
M
R
A
D
N
F
P
T
D
N
F
G
A
A
L
G
G
S
L
I
P
W
I
D
K
L
L
P
E
T
G
Q
T
K
E
E
W
K
G
Y
A
E
T
N
K
I
L
G
L
--
S
D
N
P
--
I
P
V
D
G
L
C
V
R
I
G
A
L
R
C
N
S
Q
A
F
T
I
K
L
K
K
D
L
P
L
E
E
I
E
Q
I
I
A
S
H
N
E
W
V
K
V
I
P
N
D
K
E
I
T
L
R
E
L
T
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
L
A
M
G
P
E
Y
L
A
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
V
R
R
I
L
K
Q
L
V
--
6
PsiBlast_PDB
89.42
69%
-112
- C4 -
1MB4
3
DHAS1_VIBCH
A:
[2-367]
--
R
V
G
L
V
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
V
E
E
R
D
F
D
L
I
E
P
V
F
F
S
T
S
Q
I
G
V
P
A
P
N
F
G
-
K
D
A
G
M
L
--
H
D
A
F
D
I
E
S
L
K
Q
L
D
A
V
I
T
C
Q
G
G
S
Y
T
E
K
V
Y
P
A
L
R
Q
A
G
W
K
G
Y
W
I
D
A
A
S
T
L
R
M
D
K
E
A
I
I
T
L
D
P
V
N
L
K
Q
I
L
H
G
I
H
H
G
T
K
T
F
V
G
G
N
C
T
V
S
L
M
L
M
A
L
G
G
L
Y
E
R
G
L
V
E
W
M
S
A
M
T
Y
Q
A
A
S
G
A
G
A
Q
N
M
R
E
L
I
S
Q
M
G
V
I
N
D
A
V
S
S
E
L
A
N
P
A
S
S
I
L
D
I
D
K
K
V
A
E
T
M
R
S
G
S
F
P
T
D
N
F
G
V
P
L
A
G
S
L
I
P
W
I
D
V
K
R
D
-
N
G
Q
S
K
E
E
W
K
A
G
V
E
A
N
K
I
L
G
L
--
Q
D
S
P
--
V
P
I
D
G
T
C
V
R
I
G
A
M
R
C
H
S
Q
A
L
T
I
K
L
K
Q
N
I
P
L
D
E
I
E
E
M
I
A
T
H
N
D
W
V
K
V
I
P
N
E
R
D
I
T
A
R
E
L
T
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
M
A
M
G
D
D
F
L
N
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
T
L
R
I
I
L
--
2
PsiBlast_PDB
89.28
73%
-110
- C4 -
3UW3
1
?
A:
[7-376]
---
V
G
L
V
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
Q
E
E
G
D
F
D
L
I
E
P
V
F
F
S
T
S
N
A
G
G
K
A
P
S
F
A
-
K
N
E
T
T
L
--
K
D
A
T
S
I
D
D
L
K
K
C
D
V
I
I
T
C
Q
G
G
D
Y
T
N
D
V
F
P
K
L
R
A
A
G
W
N
G
Y
W
I
D
A
A
S
S
L
R
M
K
D
D
A
V
I
I
L
D
P
V
N
L
N
V
I
K
D
A
L
V
N
G
T
K
N
F
I
G
G
N
C
T
V
S
L
M
L
M
A
L
G
G
L
F
R
E
N
L
V
D
W
M
T
A
M
T
Y
Q
A
A
S
G
A
G
A
Q
N
M
R
E
L
L
A
Q
M
G
T
L
N
G
A
V
A
A
Q
L
A
D
P
A
S
A
I
L
D
I
D
R
R
V
L
A
A
M
N
G
D
A
M
P
T
S
Q
F
G
V
P
L
A
G
S
L
I
P
W
I
D
K
D
L
G
-
N
G
M
S
R
E
E
W
K
G
G
A
E
T
N
K
I
L
G
K
PA
M
G
E
P
G
S
V
P
V
D
G
L
C
V
R
I
G
A
M
R
C
H
S
Q
A
L
T
I
K
L
K
K
D
V
P
L
D
E
I
N
G
I
L
A
S
A
N
D
W
V
K
V
V
P
N
E
R
E
A
S
M
R
D
L
S
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
L
A
M
G
G
E
Y
L
S
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
M
L
R
I
L
L
D
-
4
PsiBlast_PDB
89.10
69%
-109
- C4 -
3PZR
3
DHAS1_VIBCH
A:
[2-367]
--
R
V
G
L
V
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
V
E
E
R
D
F
D
L
I
E
P
V
F
F
S
T
S
Q
I
G
V
P
A
P
N
F
G
-
K
D
A
G
M
L
--
H
D
A
F
D
I
E
S
L
K
Q
L
D
A
V
I
T
C
Q
G
G
S
Y
T
E
K
V
Y
P
A
L
R
Q
A
G
W
K
G
Y
W
I
D
A
A
S
T
L
R
M
D
K
E
A
I
I
T
L
D
P
V
N
L
K
Q
I
L
H
G
I
H
H
G
T
K
T
F
V
G
G
N
C
T
V
S
L
M
L
M
A
L
G
G
L
Y
E
R
G
L
V
E
W
M
S
A
M
T
Y
Q
A
A
S
G
A
G
A
Q
N
M
R
E
L
I
S
Q
M
G
V
I
N
D
A
V
S
S
E
L
A
N
P
A
S
S
I
L
D
I
D
K
K
V
A
E
T
M
R
S
G
S
F
P
T
D
N
F
G
V
P
L
A
G
S
L
I
P
W
I
D
V
K
R
D
-
N
G
Q
S
K
E
E
W
K
A
G
V
E
A
N
K
I
L
G
L
--
Q
D
S
P
--
V
P
I
D
G
T
C
V
R
I
G
A
M
R
C
H
S
Q
A
L
T
I
K
L
K
Q
N
I
P
L
D
E
I
E
E
M
I
A
T
H
N
D
W
V
K
V
I
P
N
E
R
D
I
T
A
R
E
L
T
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
M
A
M
G
D
D
F
L
N
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
T
L
R
I
I
L
--
5
PsiBlast_PDB
89.02
69%
-112
- C4 -
3Q0E
3
DHAS1_VIBCH
A:
[2-367]
--
R
V
G
L
V
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
V
E
E
R
D
F
D
L
I
E
P
V
F
F
S
T
S
Q
I
G
V
P
A
P
N
F
G
-
K
D
A
G
M
L
--
H
D
A
F
D
I
E
S
L
K
Q
L
D
A
V
I
T
C
Q
G
G
S
Y
T
E
K
V
Y
P
A
L
R
Q
A
G
W
K
G
Y
W
I
D
A
A
S
T
L
R
M
D
K
E
A
I
I
T
L
D
P
V
N
L
K
Q
I
L
H
G
I
H
H
G
T
K
T
F
V
G
G
N
C
T
V
S
L
M
L
M
A
L
G
G
L
Y
E
R
G
L
V
E
W
M
S
A
M
T
Y
Q
A
A
S
G
A
G
A
Q
N
M
R
E
L
I
S
Q
M
G
V
I
N
D
A
V
S
S
E
L
A
N
P
A
S
S
I
L
D
I
D
K
K
V
A
E
T
M
R
S
G
S
F
P
T
D
N
F
G
V
P
L
A
G
S
L
I
P
W
I
D
V
K
R
D
-
N
G
Q
S
K
E
E
W
K
A
G
V
E
A
N
K
I
L
G
L
--
Q
D
S
P
--
V
P
I
D
G
T
C
V
R
I
G
A
M
R
C
H
S
Q
A
L
T
I
K
L
K
Q
N
I
P
L
D
E
I
E
E
M
I
A
T
H
N
D
W
V
K
V
I
P
N
E
R
D
I
T
A
R
E
L
T
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
M
A
M
G
D
D
F
L
N
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
T
L
R
I
I
L
--
11
PsiBlast_PDB
88.61
68%
-106
- C4 -
1T4D
-
DHAS_ECOLI
A:
[1-366]
M
Q
N
V
G
F
I
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
V
E
E
R
D
F
D
A
I
R
P
V
F
F
S
T
S
Q
L
G
Q
A
A
P
S
F
G
-
G
T
T
G
T
L
--
Q
D
A
F
D
L
E
A
L
K
A
L
D
I
I
V
T
C
Q
G
G
D
Y
T
N
E
I
Y
P
K
L
R
E
S
G
W
Q
G
Y
W
I
D
A
A
S
S
L
R
M
K
D
D
A
I
I
I
L
D
P
V
N
Q
D
V
I
T
D
G
L
N
N
G
I
R
T
F
V
G
G
N
C
T
V
S
L
M
L
M
S
L
G
G
L
F
A
N
D
L
V
D
W
V
S
V
A
T
Y
Q
A
A
S
G
G
G
A
R
H
M
R
E
L
L
T
Q
M
G
H
L
Y
G
H
V
A
D
E
L
A
T
P
S
S
A
I
L
D
I
E
R
K
V
T
T
L
T
R
S
G
E
L
P
V
D
N
F
G
V
P
L
A
G
S
L
I
P
W
I
D
K
Q
L
D
-
N
G
Q
S
R
E
E
W
K
G
Q
A
E
T
N
K
I
L
-
N
--
T
S
S
V
--
I
P
V
D
G
L
C
V
R
V
G
A
L
R
C
H
S
Q
A
F
T
I
K
L
K
K
D
V
S
I
P
T
V
E
E
L
L
A
A
H
N
P
W
A
K
V
V
P
N
D
R
E
I
T
M
R
E
L
T
P
A
A
V
T
G
T
L
T
T
P
V
G
R
L
R
K
L
N
M
G
P
E
F
L
S
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
M
L
R
Q
L
---
10
PsiBlast_PDB
88.41
68%
-107
- C4 -
1T4B
2
DHAS_ECOLI
A:
[1-366]
M
Q
N
V
G
F
I
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
V
E
E
R
D
F
D
A
I
R
P
V
F
F
S
T
S
Q
L
G
Q
A
A
P
S
F
G
-
G
T
T
G
T
L
--
Q
D
A
F
D
L
E
A
L
K
A
L
D
I
I
V
T
C
Q
G
G
D
Y
T
N
E
I
Y
P
K
L
R
E
S
G
W
Q
G
Y
W
I
D
A
A
S
S
L
R
M
K
D
D
A
I
I
I
L
D
P
V
N
Q
D
V
I
T
D
G
L
N
N
G
I
R
T
F
V
G
G
N
C
T
V
S
L
M
L
M
S
L
G
G
L
F
A
N
D
L
V
D
W
V
S
V
A
T
Y
Q
A
A
S
G
G
G
A
R
H
M
R
E
L
L
T
Q
M
G
H
L
Y
G
H
V
A
D
E
L
A
T
P
S
S
A
I
L
D
I
E
R
K
V
T
T
L
T
R
S
G
E
L
P
V
D
N
F
G
V
P
L
A
G
S
L
I
P
W
I
D
K
Q
L
D
-
N
G
Q
S
R
E
E
W
K
G
Q
A
E
T
N
K
I
L
-
N
--
T
S
S
V
--
I
P
V
D
G
L
C
V
R
V
G
A
L
R
C
H
S
Q
A
F
T
I
K
L
K
K
D
V
S
I
P
T
V
E
E
L
L
A
A
H
N
P
W
A
K
V
V
P
N
D
R
E
I
T
M
R
E
L
T
P
A
A
V
T
G
T
L
T
T
P
V
G
R
L
R
K
L
N
M
G
P
E
F
L
S
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
M
L
R
Q
L
---
28
PsiBlast_CBE
88.39
69%
-110
- C4 -
1MB4
2
DHAS1_VIBCH
B:
[2-367]
--
R
V
G
L
V
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
V
E
E
R
D
F
D
L
I
E
P
V
F
F
S
T
S
Q
I
G
V
P
A
P
N
F
G
-
K
D
A
G
M
L
--
H
D
A
F
D
I
E
S
L
K
Q
L
D
A
V
I
T
C
Q
G
G
S
Y
T
E
K
V
Y
P
A
L
R
Q
A
G
W
K
G
Y
W
I
D
A
A
S
T
L
R
M
D
K
E
A
I
I
T
L
D
P
V
N
L
K
Q
I
L
H
G
I
H
H
G
T
K
T
F
V
G
G
N
C
T
V
S
L
M
L
M
A
L
G
G
L
Y
E
R
G
L
V
E
W
M
S
A
M
T
Y
Q
A
A
S
G
A
G
A
Q
N
M
R
E
L
I
S
Q
M
G
V
I
N
D
A
V
S
S
E
L
A
N
P
A
S
S
I
L
D
I
D
K
K
V
A
E
T
M
R
S
G
S
F
P
T
D
N
F
G
V
P
L
A
G
S
L
I
P
W
I
D
V
K
R
D
-
N
G
Q
S
K
E
E
W
K
A
G
V
E
A
N
K
I
L
G
L
--
Q
D
S
P
--
V
P
I
D
G
T
C
V
R
I
G
A
M
R
C
H
S
Q
A
L
T
I
K
L
K
Q
N
I
P
L
D
E
I
E
E
M
I
A
T
H
N
D
W
V
K
V
I
P
N
E
R
D
I
T
A
R
E
L
T
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
M
A
M
G
D
D
F
L
N
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
T
L
R
I
I
L
--
27
PsiBlast_CBE
88.35
69%
-110
- C4 -
3PZR
3
DHAS1_VIBCH
B:
[2-367]
--
R
V
G
L
V
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
V
E
E
R
D
F
D
L
I
E
P
V
F
F
S
T
S
Q
I
G
V
P
A
P
N
F
G
-
K
D
A
G
M
L
--
H
D
A
F
D
I
E
S
L
K
Q
L
D
A
V
I
T
C
Q
G
G
S
Y
T
E
K
V
Y
P
A
L
R
Q
A
G
W
K
G
Y
W
I
D
A
A
S
T
L
R
M
D
K
E
A
I
I
T
L
D
P
V
N
L
K
Q
I
L
H
G
I
H
H
G
T
K
T
F
V
G
G
N
C
T
V
S
L
M
L
M
A
L
G
G
L
Y
E
R
G
L
V
E
W
M
S
A
M
T
Y
Q
A
A
S
G
A
G
A
Q
N
M
R
E
L
I
S
Q
M
G
V
I
N
D
A
V
S
S
E
L
A
N
P
A
S
S
I
L
D
I
D
K
K
V
A
E
T
M
R
S
G
S
F
P
T
D
N
F
G
V
P
L
A
G
S
L
I
P
W
I
D
V
K
R
D
-
N
G
Q
S
K
E
E
W
K
A
G
V
E
A
N
K
I
L
G
L
--
Q
D
S
P
--
V
P
I
D
G
T
C
V
R
I
G
A
M
R
C
H
S
Q
A
L
T
I
K
L
K
Q
N
I
P
L
D
E
I
E
E
M
I
A
T
H
N
D
W
V
K
V
I
P
N
E
R
D
I
T
A
R
E
L
T
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
M
A
M
G
D
D
F
L
N
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
T
L
R
I
I
L
--
26
PsiBlast_CBE
88.35
69%
-110
- C4 -
3Q0E
5
DHAS1_VIBCH
B:
[2-367]
--
R
V
G
L
V
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
V
E
E
R
D
F
D
L
I
E
P
V
F
F
S
T
S
Q
I
G
V
P
A
P
N
F
G
-
K
D
A
G
M
L
--
H
D
A
F
D
I
E
S
L
K
Q
L
D
A
V
I
T
C
Q
G
G
S
Y
T
E
K
V
Y
P
A
L
R
Q
A
G
W
K
G
Y
W
I
D
A
A
S
T
L
R
M
D
K
E
A
I
I
T
L
D
P
V
N
L
K
Q
I
L
H
G
I
H
H
G
T
K
T
F
V
G
G
N
C
T
V
S
L
M
L
M
A
L
G
G
L
Y
E
R
G
L
V
E
W
M
S
A
M
T
Y
Q
A
A
S
G
A
G
A
Q
N
M
R
E
L
I
S
Q
M
G
V
I
N
D
A
V
S
S
E
L
A
N
P
A
S
S
I
L
D
I
D
K
K
V
A
E
T
M
R
S
G
S
F
P
T
D
N
F
G
V
P
L
A
G
S
L
I
P
W
I
D
V
K
R
D
-
N
G
Q
S
K
E
E
W
K
A
G
V
E
A
N
K
I
L
G
L
--
Q
D
S
P
--
V
P
I
D
G
T
C
V
R
I
G
A
M
R
C
H
S
Q
A
L
T
I
K
L
K
Q
N
I
P
L
D
E
I
E
E
M
I
A
T
H
N
D
W
V
K
V
I
P
N
E
R
D
I
T
A
R
E
L
T
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
M
A
M
G
D
D
F
L
N
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
T
L
R
I
I
L
--
7
PsiBlast_PDB
88.16
69%
-110
- C4 -
4R5M
4
DHAS1_VIBCH
A:
[2-367]
--
R
V
G
L
V
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
V
E
E
R
D
F
D
L
I
E
P
V
F
F
S
T
S
Q
I
G
V
P
A
P
N
F
G
-
K
D
A
G
M
L
--
H
D
A
F
D
I
E
S
L
K
Q
L
D
A
V
I
T
C
Q
G
G
S
Y
T
E
K
V
Y
P
A
L
R
Q
A
G
W
K
G
Y
W
I
D
A
A
S
T
L
R
M
D
K
E
A
I
I
T
L
D
P
V
N
L
K
Q
I
L
H
G
I
H
H
G
T
K
T
F
V
G
G
N
C
T
V
S
L
M
L
M
A
L
G
G
L
Y
E
R
G
L
V
E
W
M
S
A
M
T
Y
Q
A
A
S
G
A
G
A
Q
N
M
R
E
L
I
S
Q
M
G
V
I
N
D
A
V
S
S
E
L
A
N
P
A
S
S
I
L
D
I
D
K
K
V
A
E
T
M
R
S
G
S
F
P
T
D
N
F
G
V
P
L
A
G
S
L
I
P
W
I
D
V
K
R
D
-
N
G
Q
S
K
E
E
W
K
A
G
V
E
A
N
K
I
L
G
L
--
Q
D
S
P
--
V
P
I
D
G
T
C
V
R
I
G
A
M
R
C
H
S
Q
A
L
T
I
K
L
K
Q
N
I
P
L
D
E
I
E
E
M
I
A
T
H
N
D
W
V
K
V
I
P
N
E
R
D
I
T
A
R
E
L
T
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
M
A
M
G
D
D
F
L
N
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
T
L
R
I
I
L
--
54
Fugue
87.73
69%
-106
* C4 *
1GL3
3
DHAS_ECOLI
A:
[1-367]
M
K
N
V
G
F
I
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
V
E
E
R
D
F
D
A
I
R
P
V
F
F
S
T
S
Q
L
G
Q
A
A
P
S
F
G
-
G
T
T
G
T
L
--
Q
D
A
F
D
L
E
A
L
K
A
L
D
I
I
V
T
C
Q
G
G
D
Y
T
N
E
I
Y
P
K
L
R
E
S
G
W
Q
G
Y
W
I
D
A
A
S
S
L
R
M
K
D
D
A
I
I
I
L
D
P
V
N
Q
D
V
I
T
D
G
L
N
N
G
I
R
T
F
V
G
G
N
C
T
V
S
L
M
L
M
S
L
G
G
L
F
A
N
D
L
V
D
W
V
S
V
A
T
Y
Q
A
A
S
G
G
G
A
R
H
M
R
E
L
L
T
Q
M
G
H
L
Y
G
H
V
A
D
E
L
A
T
P
S
S
A
I
L
D
I
E
R
K
V
T
T
L
T
R
S
G
E
L
P
V
D
N
F
G
V
P
L
A
G
S
L
I
P
W
I
D
K
Q
L
D
-
N
G
Q
S
R
E
E
W
K
G
Q
A
E
T
N
K
I
L
N
T
---
S
S
V
--
I
P
V
D
G
L
C
V
R
V
G
A
L
R
C
H
S
Q
A
F
T
I
K
L
K
K
D
V
S
I
P
T
V
E
E
L
L
A
A
H
N
P
W
A
K
V
V
P
N
D
R
E
I
T
M
R
E
L
T
P
A
A
V
T
G
T
L
T
T
P
V
G
R
L
R
K
L
N
M
G
P
E
F
L
S
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
M
L
R
Q
L
A
--
30
PsiBlast_CBE
87.73
66%
-108
- C4 -
1PQU
3
DHAS_HAEIN
D:
[1-370]
M
K
N
V
G
F
I
G
W
R
G
M
V
G
S
V
L
M
D
R
M
S
Q
E
N
D
F
E
N
L
N
P
V
F
F
T
T
S
Q
A
G
Q
K
A
P
V
F
G
G
K
D
A
G
D
L
--
K
S
A
F
D
I
E
E
L
K
K
L
D
I
I
V
T
C
Q
G
G
D
Y
T
N
E
V
Y
P
K
L
K
A
T
G
W
D
G
Y
W
V
D
A
A
S
A
L
R
M
K
D
D
A
I
I
V
L
D
P
V
N
Q
H
V
I
S
E
G
L
K
K
G
I
K
T
F
V
G
G
N
C
T
V
S
L
M
L
M
A
I
G
G
L
F
E
K
D
L
V
E
W
I
S
V
A
T
Y
Q
A
A
S
G
A
G
A
K
N
M
R
E
L
L
S
Q
M
G
L
L
E
Q
A
V
S
S
E
L
K
D
P
A
S
S
I
L
D
I
E
R
K
V
T
A
K
M
R
A
D
N
F
P
T
D
N
F
G
A
A
L
G
G
S
L
I
P
W
I
D
K
L
L
P
E
T
G
Q
T
K
E
E
W
K
G
Y
A
E
T
N
K
I
L
G
L
--
S
D
N
P
--
I
P
V
D
G
L
C
V
R
I
G
A
L
R
C
N
S
Q
A
F
T
I
K
L
K
K
D
L
P
L
E
E
I
E
Q
I
I
A
S
H
N
E
W
V
K
V
I
P
N
D
K
E
I
T
L
R
E
L
T
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
L
A
M
G
P
E
Y
L
A
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
V
R
R
I
L
K
Q
L
V
--
29
PsiBlast_CBE
87.70
69%
-106
- C4 -
1GL3
3
DHAS_ECOLI
A:
[1-366]
M
K
N
V
G
F
I
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
V
E
E
R
D
F
D
A
I
R
P
V
F
F
S
T
S
Q
L
G
Q
A
A
P
S
F
G
-
G
T
T
G
T
L
--
Q
D
A
F
D
L
E
A
L
K
A
L
D
I
I
V
T
C
Q
G
G
D
Y
T
N
E
I
Y
P
K
L
R
E
S
G
W
Q
G
Y
W
I
D
A
A
S
S
L
R
M
K
D
D
A
I
I
I
L
D
P
V
N
Q
D
V
I
T
D
G
L
N
N
G
I
R
T
F
V
G
G
N
C
T
V
S
L
M
L
M
S
L
G
G
L
F
A
N
D
L
V
D
W
V
S
V
A
T
Y
Q
A
A
S
G
G
G
A
R
H
M
R
E
L
L
T
Q
M
G
H
L
Y
G
H
V
A
D
E
L
A
T
P
S
S
A
I
L
D
I
E
R
K
V
T
T
L
T
R
S
G
E
L
P
V
D
N
F
G
V
P
L
A
G
S
L
I
P
W
I
D
K
Q
L
D
-
N
G
Q
S
R
E
E
W
K
G
Q
A
E
T
N
K
I
L
-
N
--
T
S
S
V
--
I
P
V
D
G
L
C
V
R
V
G
A
L
R
C
H
S
Q
A
F
T
I
K
L
K
K
D
V
S
I
P
T
V
E
E
L
L
A
A
H
N
P
W
A
K
V
V
P
N
D
R
E
I
T
M
R
E
L
T
P
A
A
V
T
G
T
L
T
T
P
V
G
R
L
R
K
L
N
M
G
P
E
F
L
S
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
M
L
R
Q
L
---
32
PsiBlast_CBE
87.65
66%
-110
- C4 -
1PQU
3
DHAS_HAEIN
B:
[1-370]
M
K
N
V
G
F
I
G
W
R
G
M
V
G
S
V
L
M
D
R
M
S
Q
E
N
D
F
E
N
L
N
P
V
F
F
T
T
S
Q
A
G
Q
K
A
P
V
F
G
G
K
D
A
G
D
L
--
K
S
A
F
D
I
E
E
L
K
K
L
D
I
I
V
T
C
Q
G
G
D
Y
T
N
E
V
Y
P
K
L
K
A
T
G
W
D
G
Y
W
V
D
A
A
S
A
L
R
M
K
D
D
A
I
I
V
L
D
P
V
N
Q
H
V
I
S
E
G
L
K
K
G
I
K
T
F
V
G
G
N
C
T
V
S
L
M
L
M
A
I
G
G
L
F
E
K
D
L
V
E
W
I
S
V
A
T
Y
Q
A
A
S
G
A
G
A
K
N
M
R
E
L
L
S
Q
M
G
L
L
E
Q
A
V
S
S
E
L
K
D
P
A
S
S
I
L
D
I
E
R
K
V
T
A
K
M
R
A
D
N
F
P
T
D
N
F
G
A
A
L
G
G
S
L
I
P
W
I
D
K
L
L
P
E
T
G
Q
T
K
E
E
W
K
G
Y
A
E
T
N
K
I
L
G
L
--
S
D
N
P
--
I
P
V
D
G
L
C
V
R
I
G
A
L
R
C
N
S
Q
A
F
T
I
K
L
K
K
D
L
P
L
E
E
I
E
Q
I
I
A
S
H
N
E
W
V
K
V
I
P
N
D
K
E
I
T
L
R
E
L
T
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
L
A
M
G
P
E
Y
L
A
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
V
R
R
I
L
K
Q
L
V
--
25
PsiBlast_CBE
87.61
69%
-108
- C4 -
4R5M
2
DHAS1_VIBCH
B:
[2-367]
--
R
V
G
L
V
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
V
E
E
R
D
F
D
L
I
E
P
V
F
F
S
T
S
Q
I
G
V
P
A
P
N
F
G
-
K
D
A
G
M
L
--
H
D
A
F
D
I
E
S
L
K
Q
L
D
A
V
I
T
C
Q
G
G
S
Y
T
E
K
V
Y
P
A
L
R
Q
A
G
W
K
G
Y
W
I
D
A
A
S
T
L
R
M
D
K
E
A
I
I
T
L
D
P
V
N
L
K
Q
I
L
H
G
I
H
H
G
T
K
T
F
V
G
G
N
C
T
V
S
L
M
L
M
A
L
G
G
L
Y
E
R
G
L
V
E
W
M
S
A
M
T
Y
Q
A
A
S
G
A
G
A
Q
N
M
R
E
L
I
S
Q
M
G
V
I
N
D
A
V
S
S
E
L
A
N
P
A
S
S
I
L
D
I
D
K
K
V
A
E
T
M
R
S
G
S
F
P
T
D
N
F
G
V
P
L
A
G
S
L
I
P
W
I
D
V
K
R
D
-
N
G
Q
S
K
E
E
W
K
A
G
V
E
A
N
K
I
L
G
L
--
Q
D
S
P
--
V
P
I
D
G
T
C
V
R
I
G
A
M
R
C
H
S
Q
A
L
T
I
K
L
K
Q
N
I
P
L
D
E
I
E
E
M
I
A
T
H
N
D
W
V
K
V
I
P
N
E
R
D
I
T
A
R
E
L
T
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
M
A
M
G
D
D
F
L
N
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
T
L
R
I
I
L
--
33
HHSearch
87.37
68%
-107
- C4 -
3PZR
3
DHAS1_VIBCH
A:
[1-369]
-
M
R
V
G
L
V
G
W
R
G
M
V
G
S
V
L
M
Q
R
M
V
E
E
R
D
F
D
L
I
E
P
V
F
F
S
T
S
Q
I
G
V
P
A
P
N
F
G
-
K
-
D
A
G
M
LH
D
A
F
D
-
I
E
S
L
K
Q
L
D
A
V
I
T
C
Q
G
G
S
Y
T
E
K
V
Y
P
A
L
R
Q
A
G
W
K
G
Y
W
I
D
A
A
S
T
L
R
M
D
K
E
A
I
I
T
L
D
P
V
N
L
K
Q
I
L
H
G
I
H
H
G
T
K
T
F
V
G
G
N
C
T
V
S
L
M
L
M
A
L
G
G
L
Y
E
R
G
L
V
E
W
M
S
A
M
T
Y
Q
A
A
S
G
A
G
A
Q
N
M
R
E
L
I
S
Q
M
G
V
I
N
D
A
V
S
S
E
L
A
N
P
A
S
S
I
L
D
I
D
K
K
V
A
E
T
M
R
S
G
S
F
P
T
D
N
F
G
V
P
L
A
G
S
L
I
P
W
I
D
V
K
R
D
-
N
G
Q
S
K
E
E
W
K
A
G
V
E
A
N
K
I
L
G
L
--
Q
D
S
P
--
V
P
I
D
G
T
C
V
R
I
G
A
M
R
C
H
S
Q
A
L
T
I
K
L
K
Q
N
I
P
L
D
E
I
E
E
M
I
A
T
H
N
D
W
V
K
V
I
P
N
E
R
D
I
T
A
R
E
L
T
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
M
A
M
G
D
D
F
L
N
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
L
R
R
T
L
R
I
I
L
A
E
13
PsiBlast_PDB
86.04
67%
-115
- C4 -
1TA4
2
DHAS_HAEIN
A:
[1-370]
M
K
N
V
G
F
I
G
W
R
G
M
V
G
S
V
L
M
D
R
M
S
Q
E
N
D
F
E
N
L
N
P
V
F
F
T
T
S
Q
A
--------------
L
--
K
S
A
F
D
I
E
E
L
K
K
L
D
I
I
V
T
C
Q
G
G
D
Y
T
N
E
V
Y
P
K
L
K
A
T
G
W
D
G
Y
W
V
D
A
A
S
A
L
R
M
K
D
D
A
I
I
V
L
D
P
V
N
Q
H
V
I
S
E
G
L
K
K
G
I
K
T
F
V
G
G
N
C
T
V
S
L
M
L
M
A
I
G
G
L
F
E
K
D
L
V
E
W
I
S
V
A
T
Y
Q
A
A
S
G
A
G
A
K
N
M
R
E
L
L
S
Q
M
G
L
L
E
Q
A
V
S
S
E
L
K
D
P
A
S
S
I
L
D
I
E
R
K
V
T
A
K
M
R
A
D
N
F
P
T
D
N
F
G
A
A
L
G
G
S
L
I
P
W
I
D
K
L
L
P
E
T
G
Q
T
K
E
E
W
K
G
Y
A
E
T
N
K
I
L
G
L
--
S
D
N
P
--
I
P
V
D
G
L
C
V
R
I
G
A
L
R
C
H
S
Q
A
F
T
I
K
L
K
K
D
L
P
L
E
E
I
E
Q
I
I
A
S
H
N
E
W
V
K
V
I
P
N
D
K
E
I
T
L
R
E
L
T
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
L
A
M
G
P
E
Y
L
A
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
V
R
R
I
L
K
Q
L
V
--
14
PsiBlast_PDB
86.00
67%
-112
- C4 -
1TB4
1
DHAS_HAEIN
A:
[1-370]
M
K
N
V
G
F
I
G
W
R
G
M
V
G
S
V
L
M
D
R
M
S
Q
E
N
D
F
E
N
L
N
P
V
F
F
T
T
S
Q
A
--------------
L
--
K
S
A
F
D
I
E
E
L
K
K
L
D
I
I
V
T
C
Q
G
G
D
Y
T
N
E
V
Y
P
K
L
K
A
T
G
W
D
G
Y
W
V
D
A
A
S
A
L
R
M
K
D
D
A
I
I
V
L
D
P
V
N
Q
H
V
I
S
E
G
L
K
K
G
I
K
T
F
V
G
G
N
C
T
V
S
L
M
L
M
A
I
G
G
L
F
E
K
D
L
V
E
W
I
S
V
A
T
Y
Q
A
A
S
G
A
G
A
K
N
M
R
E
L
L
S
Q
M
G
L
L
E
Q
A
V
S
S
E
L
K
D
P
A
S
S
I
L
D
I
E
R
K
V
T
A
K
M
R
A
D
N
F
P
T
D
N
F
G
A
A
L
G
G
S
L
I
P
W
I
D
K
L
L
P
E
T
G
Q
T
K
E
E
W
K
G
Y
A
E
T
N
K
I
L
G
L
--
S
D
N
P
--
I
P
V
D
G
L
C
V
R
I
G
A
L
R
C
H
S
Q
A
F
T
I
K
L
K
K
D
L
P
L
E
E
I
E
Q
I
I
A
S
H
N
E
W
V
K
V
I
P
N
D
K
E
I
T
L
R
E
L
T
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
L
A
M
G
P
E
Y
L
A
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
V
R
R
I
L
K
Q
L
V
--
19
PsiBlast_PDB
85.62
66%
-112
- C4 -
1PQP
2
DHAS_HAEIN
A:
[1-370]
M
K
N
V
G
F
I
G
W
R
G
M
V
G
S
V
L
M
D
R
M
S
Q
E
N
D
F
E
N
L
N
P
V
F
F
T
T
S
Q
A
--------------
L
--
K
S
A
F
D
I
E
E
L
K
K
L
D
I
I
V
T
C
Q
G
G
D
Y
T
N
E
V
Y
P
K
L
K
A
T
G
W
D
G
Y
W
V
D
A
A
S
A
L
R
M
K
D
D
A
I
I
V
L
D
P
V
N
Q
H
V
I
S
E
G
L
K
K
G
I
K
T
F
V
G
G
N
S
T
V
S
L
M
L
M
A
I
G
G
L
F
E
K
D
L
V
E
W
I
S
V
A
T
Y
Q
A
A
S
G
A
G
A
K
N
M
R
E
L
L
S
Q
M
G
L
L
E
Q
A
V
S
S
E
L
K
D
P
A
S
S
I
L
D
I
E
R
K
V
T
A
K
M
R
A
D
N
F
P
T
D
N
F
G
A
A
L
G
G
S
L
I
P
W
I
D
K
L
L
P
E
T
G
Q
T
K
E
E
W
K
G
Y
A
E
T
N
K
I
L
G
L
--
S
D
N
P
--
I
P
V
D
G
L
C
V
R
I
G
A
L
R
C
H
S
Q
A
F
T
I
K
L
K
K
D
L
P
L
E
E
I
E
Q
I
I
A
S
H
N
E
W
V
K
V
I
P
N
D
K
E
I
T
L
R
E
L
T
P
A
K
V
T
G
T
L
S
V
P
V
G
R
L
R
K
L
A
M
G
P
E
Y
L
A
A
F
T
V
G
D
Q
L
L
W
G
A
A
E
P
V
R
R
I
L
K
Q
L
V
--