@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3118: (2016-02-14 )
MSKQILVLPGDGIGPEIMAEAVKVLELANDRFQLGFELAEDVIGGAAIDKHGVPLADQTLQRARQADAVLLGAVGGPKWDRIERDIRPERGLLKIRSQLGLFANLRPAILYPQLAAASSLKPEVVAGLDILIVRELTGGIYFGQPREQRVLENGERQAYDTLPYSESEIRRIARVGFDMARVRNNRLCSVDKANVLASSQLWREVVEEVAKDYPDVELSHMYVDNAAMQLVRAPKQFDVMVTDNMFGDILSDEASMLTGSIGMLPSASLDANNKGMYEPCHGSAPDIAGQGIANPLATILSVSMMLRYSFSQATAADAIEQAVSKVLDQGLRTGDIWSEGCRKVGTREMGDAVVAALKNL
Atome Classification :
(41 SA)
----------------...--......10........20........30....---....40........---50....--.....60...-.....70........80...-.....90-........100.......110.......120.-..-.-...130.....-------..140...-------....150.--.----.....160.......170.......180--.-------------..-------------.-...190...--.-.-.-.200.....---...210-...--......220.......230.......240.......250.......260.......270-........280.......290.......300......----.310.......320.......330-.....--.--..--340...--....350.......360----------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------MS
K
--
Q
I
L
V
L
PGDGI
G
P
E
I
M
A
E
A
V
K
V
L
E
LAN
D
R
F
Q
L
G
---
F
E
L
A
E
D
VIGGAAID---K-HGVP--
L
A
D
Q
T
L
Q
R
A
R-QA
D
A
V
L
L
GAVGGP
K
W
D
R
I
E
R-DIRPE
R
G
-
L
L
K
I
R
S
QLGLFANL
R
P
A
IL
Y
P
Q
L
AAASSLK
P
E
-
V
V-A-G
L
D
I
L
I
V
R
E
LT-------GGIYFGQ
P
-------
R
E
Q
R
V
L
EN--G----ERQAYDTLPY
S
E
S
E
I
R
R
I
A
R
VG
F
D
M
A
R
V--R-------------NN-------------R-LCSV
D
K
A
N
V
--
L
-
A
-
S
-
S
Q
-
L
W
R
E
V
V
---
E
E
V
A
---
K
DY--PDVE
L
S
H
M
YV
D
N
A
A
M
Q
L
VRAP
K
Q
F
D
V
M
VTD
N
M
F
G
D
I
LSD
E
A
S
M
LTGSIGMLPSASLDA--NNKGMYEPCHGSAPDIAGQG
I
A
N
P
L
A
T
I
L
S
V
S
M
M
L
R
Y----SFSQA
T
A
A
D
A
I
E
Q
A
V
S
K
V
L
D
QG-L-RTGD
I
--
W
--
S
E
--
G
C
R
KVG--
T
R
E
M
G
D
A
V
V
A
A
L
KNL------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
97.90
65%
-103
- C8 -
4XXV
3
LEU3_BURTA
B:
[10-363]
---------------------
K
I
A
V
L
P
G
D
G
I
G
P
E
I
V
N
E
A
V
K
V
L
N
A
L
D
E
K
F
-------
E
L
E
H
A
P
V
G
G
A
G
Y
E
---
A
-
S
G
H
P
--
L
P
D
A
T
L
A
L
A
K
-
E
A
D
A
I
L
F
G
A
V
G
D
W
K
Y
D
S
L
E
R
-
A
L
R
P
E
Q
A
-
I
L
G
L
R
K
H
L
E
L
F
A
N
F
R
P
A
I
C
Y
P
Q
L
V
D
A
S
P
L
K
P
E
-
L
V
-
A
-
G
L
D
I
L
I
V
R
E
L
N
-------
G
D
I
Y
F
G
Q
P
-------
R
G
V
R
A
A
P
D
--
G
PFAG
E
R
E
G
F
D
T
M
R
Y
S
E
P
E
V
R
R
I
A
H
V
A
F
Q
A
A
Q
K
--
R
-------------
A
K
-------------
K
-
L
L
S
V
D
K
S
N
V
--
L
-
E
-
T
-
S
Q
-
F
W
R
D
V
M
---
I
D
V
S
---
K
E
Y
--
A
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
A
K
A
P
K
Q
F
D
V
I
V
T
G
N
M
F
G
D
I
L
S
D
E
A
S
M
L
T
G
S
I
G
M
L
P
S
A
S
L
D
K
--
N
N
K
G
L
Y
E
P
S
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
L
L
R
Y
----
S
L
N
R
A
E
Q
A
D
R
I
E
R
A
V
K
T
V
L
E
Q
G
-
Y
-
R
T
G
D
I
--
A
--
T
P
--
G
C
R
Q
V
G
--
T
A
A
M
G
D
A
V
V
A
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
97.69
65%
-101
- C8 -
4IWH
2
LEU3_BURTA
B:
[10-363]
---------------------
K
I
A
V
L
P
G
D
G
I
G
P
E
I
V
N
E
A
V
K
V
L
N
A
L
D
E
K
F
-------
E
L
E
H
A
P
V
G
G
A
G
Y
E
---
A
-
S
G
H
P
--
L
P
D
A
T
L
A
L
A
K
-
E
A
D
A
I
L
F
G
A
V
G
D
W
K
Y
D
S
L
E
R
-
A
L
R
P
E
Q
A
-
I
L
G
L
R
K
H
L
E
L
F
A
N
F
R
P
A
I
C
Y
P
Q
L
V
D
A
S
P
L
K
P
E
-
L
V
-
A
-
G
L
D
I
L
I
V
R
E
L
N
-------
G
D
I
Y
F
G
Q
P
-------
R
G
V
R
A
A
P
D
--
G
PFAG
E
R
E
G
F
D
T
M
R
Y
S
E
P
E
V
R
R
I
A
H
V
A
F
Q
A
A
Q
K
--
R
-------------
A
K
-------------
K
-
L
L
S
V
D
K
S
N
V
--
L
-
E
-
T
-
S
Q
-
F
W
R
D
V
M
---
I
D
V
S
---
K
E
Y
--
A
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
A
K
A
P
K
Q
F
D
V
I
V
T
G
N
M
F
G
D
I
L
S
D
E
A
S
M
L
T
G
S
I
G
M
L
P
S
A
S
L
D
K
--
N
N
K
G
L
Y
E
P
S
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
L
L
R
Y
----
S
L
N
R
A
E
Q
A
D
R
I
E
R
A
V
K
T
V
L
E
Q
G
-
Y
-
R
T
G
D
I
--
A
--
T
P
--
G
C
R
Q
V
G
--
T
A
A
M
G
D
A
V
V
A
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
97.39
65%
-101
- C8 -
4XXV
2
LEU3_BURTA
A:
[10-363]
---------------------
K
I
A
V
L
P
G
D
G
I
G
P
E
I
V
N
E
A
V
K
V
L
N
A
L
D
E
K
F
-------
E
L
E
H
A
P
V
G
G
A
G
Y
E
---
A
-
S
G
H
P
--
L
P
D
A
T
L
A
L
A
K
-
E
A
D
A
I
L
F
G
A
V
G
D
W
K
Y
D
S
L
E
R
-
A
L
R
P
E
Q
A
-
I
L
G
L
R
K
H
L
E
L
F
A
N
F
R
P
A
I
C
Y
P
Q
L
V
D
A
S
P
L
K
P
E
-
L
V
-
A
-
G
L
D
I
L
I
V
R
E
L
N
-------
G
D
I
Y
F
G
Q
P
-------
R
G
V
R
A
A
P
D
--
G
PFAG
E
R
E
G
F
D
T
M
R
Y
S
E
P
E
V
R
R
I
A
H
V
A
F
Q
A
A
Q
K
--
R
-------------
A
K
-------------
K
-
L
L
S
V
D
K
S
N
V
--
L
-
E
-
T
-
S
Q
-
F
W
R
D
V
M
---
I
D
V
S
---
K
E
Y
--
A
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
A
K
A
P
K
Q
F
D
V
I
V
T
G
N
M
F
G
D
I
L
S
D
E
A
S
M
L
T
G
S
I
G
M
L
P
S
A
S
L
D
K
--
N
N
K
G
L
Y
E
P
S
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
L
L
R
Y
----
S
L
N
R
A
E
Q
A
D
R
I
E
R
A
V
K
T
V
L
E
Q
G
-
Y
-
R
T
G
D
I
--
A
--
T
P
--
G
C
R
Q
V
G
--
T
A
A
M
G
D
A
V
V
A
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.79
65%
-100
- C8 -
4IWH
2
LEU3_BURTA
A:
[10-363]
---------------------
K
I
A
V
L
P
G
D
G
I
G
P
E
I
V
N
E
A
V
K
V
L
N
A
L
D
E
K
F
-------
E
L
E
H
A
P
V
G
G
A
G
Y
E
---
A
-
S
G
H
P
--
L
P
D
A
T
L
A
L
A
K
-
E
A
D
A
I
L
F
G
A
V
G
D
W
K
Y
D
S
L
E
R
-
A
L
R
P
E
Q
A
-
I
L
G
L
R
K
H
L
E
L
F
A
N
F
R
P
A
I
C
Y
P
Q
L
V
D
A
S
P
L
K
P
E
-
L
V
-
A
-
G
L
D
I
L
I
V
R
E
L
N
-------
G
D
I
Y
F
G
Q
P
-------
R
G
V
R
A
A
P
D
--
G
PFAG
E
R
E
G
F
D
T
M
R
Y
S
E
P
E
V
R
R
I
A
H
V
A
F
Q
A
A
Q
K
--
R
-------------
A
K
-------------
K
-
L
L
S
V
D
K
S
N
V
--
L
-
E
-
T
-
S
Q
-
F
W
R
D
V
M
---
I
D
V
S
---
K
E
Y
--
A
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
A
K
A
P
K
Q
F
D
V
I
V
T
G
N
M
F
G
D
I
L
S
D
E
A
S
M
L
T
G
S
I
G
M
L
P
S
A
S
L
D
K
--
N
N
K
G
L
Y
E
P
S
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
L
L
R
Y
----
S
L
N
R
A
E
Q
A
D
R
I
E
R
A
V
K
T
V
L
E
Q
G
-
Y
-
R
T
G
D
I
--
A
--
T
P
--
G
C
R
Q
V
G
--
T
A
A
M
G
D
A
V
V
A
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
89
Fugue
94.09
61%
-102
- C8 -
1A05
4
LEU3_ACIFR
A:
[1-357]
-----------------
M
K
--
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
D
A
V
D
Q
A
A
---HLG
L
R
C
T
E
G
L
V
G
G
A
A
L
D
---
A
-
S
D
D
P
--
L
P
A
A
S
L
Q
L
A
M
-
A
A
D
A
V
I
L
G
A
V
G
G
P
R
W
D
A
Y
P
P
-
A
K
R
P
E
-
Q
G
L
L
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
L
D
A
S
P
L
R
P
E
-
L
V
-
R
-
D
V
D
I
L
V
V
R
E
L
T
-------
G
D
I
Y
F
G
Q
P
R
G
L
E
V
I
D----------
G
----
K
R
R
G
F
N
T
M
V
Y
D
E
D
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
--
R
-------------
R
K
-------------
Q
-
L
C
S
V
D
K
A
N
V
--
L
-
E
-
T
-
T
R
-
L
W
R
E
V
V
---
T
E
V
A
---
R
-
D
Y
P-
D
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
G
E
---
G
R
A
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
H
----
S
L
N
A
E
P
W
A
Q
R
V
E
A
A
V
Q
R
V
L
D
Q
G
-
L
-
R
T
A
D
I
--
A
AP----
G
T
P
V
I
G
--
T
K
A
M
G
A
A
V
V
N
A
L
N
L
K
------------------------------------------------------------------------------------------------------------------------------------------
99
HHSearch
93.87
62%
-98
- C8 -
1A05
4
LEU3_ACIFR
A:
[1-356]
-----------------
M
K
--
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
D
A
V
D
Q
A
A
H
L
G
---
L
R
C
T
E
G
L
V
G
G
A
A
L
D
---
A
-
S
D
D
P
--
L
P
A
A
S
L
Q
L
A
M
-
A
A
D
A
V
I
L
G
A
V
G
G
P
R
W
D
A
Y
P
P
-
A
K
R
P
E
Q
G
-
L
L
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
L
D
A
S
P
L
R
P
E
-
L
V
-
R
-
D
V
D
I
L
V
V
R
E
L
T
-------
G
D
I
Y
F
G
Q
P
-------
R
G
L
E
V
-
I
D
--
G
----
K
R
R
G
F
N
T
M
V
Y
D
E
D
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
--
R
-------------
R
K
-------------
Q
-
L
C
S
V
D
K
A
N
V
--
L
-
E
-
T
-
T
R
-
L
W
R
E
V
V
---
T
E
V
A
---
R
D
Y
--
P
D
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
G
E
---
G
R
A
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
H
----
S
L
N
A
E
P
W
A
Q
R
V
E
A
A
V
Q
R
V
L
D
Q
G
-
L
-
R
T
A
D
I
--
A
--
A
P
--
G
T
P
V
I
G
--
T
K
A
M
G
A
A
V
V
N
A
L
N
L
-------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
93.84
61%
-101
- C8 -
1A05
4
LEU3_ACIFR
A:
[2-355]
------------------
K
--
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
D
A
V
D
Q
A
A
H
L
G
---
L
R
C
T
E
G
L
V
G
G
A
A
L
D
---
A
-
S
D
D
P
--
L
P
A
A
S
L
Q
L
A
M
-
A
A
D
A
V
I
L
G
A
V
G
G
P
R
W
D
A
Y
P
P
-
A
K
R
P
E
Q
G
-
L
L
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
L
D
A
S
P
L
R
P
E
-
L
V
-
R
-
D
V
D
I
L
V
V
R
E
L
T
-------
G
D
I
Y
F
G
Q
P
-------
R
G
L
E
V
I
-
D
--
G
----
K
R
R
G
F
N
T
M
V
Y
D
E
D
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
--
R
-------------
R
K
-------------
Q
-
L
C
S
V
D
K
A
N
V
--
L
-
E
-
T
-
T
R
-
L
W
R
E
V
V
---
T
E
V
A
---
R
D
Y
--
P
D
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
-
G
--
E
G
R
A
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
H
----
S
L
N
A
E
P
W
A
Q
R
V
E
A
A
V
Q
R
V
L
D
Q
G
-
L
-
R
T
A
D
I
--
A
--
A
P
--
G
T
P
V
I
G
--
T
K
A
M
G
A
A
V
V
N
A
L
N
--------------------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
93.83
63%
-105
- C8 -
3U1H
-
?
A:
[3-357]
------------------
K
--
K
I
A
V
L
P
G
D
G
I
G
P
E
V
M
E
A
A
I
E
V
L
K
A
V
A
E
R
F
G
H
E
---
F
E
F
E
Y
G
L
I
G
G
A
A
I
D
---
E
-
A
G
T
P
--
L
P
E
E
T
L
D
V
C
R
-
G
S
D
A
I
L
L
G
A
V
G
G
P
K
W
D
Q
N
P
S
-
E
L
R
P
E
K
G
-
L
L
G
I
R
K
G
L
D
L
F
A
N
L
R
P
V
K
V
Y
D
S
L
A
D
A
S
P
L
K
K
E
-
V
I
-
E
-
G
V
D
L
V
I
V
R
E
L
T
-------
G
G
L
Y
F
----------------
E
E
--
G
----
E
E
A
A
V
D
T
L
L
Y
T
R
E
E
I
E
R
I
I
R
K
A
F
E
L
A
L
T
--
R
-------------
K
K
-------------
K
-
V
T
S
V
D
K
A
N
V
--
L
-
E
-
S
-
S
R
-
L
W
R
E
V
A
---
E
E
V
A
---
K
E
Y
--
P
D
V
E
L
E
H
M
L
V
D
N
A
A
M
Q
L
I
R
N
P
R
Q
F
D
V
I
V
T
E
N
M
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
L
G
M
L
P
S
A
S
L
S
T
--
D
G
L
G
L
Y
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
M
L
R
Y
----
S
F
G
L
E
E
E
A
K
A
I
E
K
A
V
E
K
V
L
A
E
G
-
Y
-
R
T
A
D
I
--
A
--
K
P
--
G
G
K
Y
V
S
--
T
T
E
M
T
D
E
V
K
A
A
V
V
D
-------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.35
63%
-105
- C8 -
3U1H
-
?
A:
[3-355]
------------------
K
--
K
I
A
V
L
P
G
D
G
I
G
P
E
V
M
E
A
A
I
E
V
L
K
A
V
A
E
R
F
G
H
E
---
F
E
F
E
Y
G
L
I
G
G
A
A
I
D
---
E
-
A
G
T
P
--
L
P
E
E
T
L
D
V
C
R
-
G
S
D
A
I
L
L
G
A
V
G
G
P
K
W
D
Q
N
P
S
-
E
L
R
P
E
K
G
-
L
L
G
I
R
K
G
L
D
L
F
A
N
L
R
P
V
K
V
Y
D
S
L
A
D
A
S
P
L
K
K
E
-
V
I
-
E
-
G
V
D
L
V
I
V
R
E
L
T
-------
G
G
L
Y
F
----------------
E
E
--
G
----
E
E
A
A
V
D
T
L
L
Y
T
R
E
E
I
E
R
I
I
R
K
A
F
E
L
A
L
T
--
R
-------------
K
K
-------------
K
-
V
T
S
V
D
K
A
N
V
--
L
-
E
-
S
-
S
R
-
L
W
R
E
V
A
---
E
E
V
A
---
K
E
Y
--
P
D
V
E
L
E
H
M
L
V
D
N
A
A
M
Q
L
I
R
N
P
R
Q
F
D
V
I
V
T
E
N
M
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
L
G
M
L
P
S
A
S
L
S
T
--
D
G
L
G
L
Y
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
M
L
R
Y
----
S
F
G
L
E
E
E
A
K
A
I
E
K
A
V
E
K
V
L
A
E
G
-
Y
-
R
T
A
D
I
--
A
--
K
P
--
G
G
K
Y
V
S
--
T
T
E
M
T
D
E
V
K
A
A
V
---------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
93.23
61%
-98
- C8 -
1A05
4
LEU3_ACIFR
B:
[2-355]
------------------
K
--
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
D
A
V
D
Q
A
A
H
L
G
---
L
R
C
T
E
G
L
V
G
G
A
A
L
D
---
A
-
S
D
D
P
--
L
P
A
A
S
L
Q
L
A
M
-
A
A
D
A
V
I
L
G
A
V
G
G
P
R
W
D
A
Y
P
P
-
A
K
R
P
E
Q
G
-
L
L
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
L
D
A
S
P
L
R
P
E
-
L
V
-
R
-
D
V
D
I
L
V
V
R
E
L
T
-------
G
D
I
Y
F
G
Q
P
-------
R
G
L
E
V
I
-
D
--
G
----
K
R
R
G
F
N
T
M
V
Y
D
E
D
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
--
R
-------------
R
K
-------------
Q
-
L
C
S
V
D
K
A
N
V
--
L
-
E
-
T
-
T
R
-
L
W
R
E
V
V
---
T
E
V
A
---
R
D
Y
--
P
D
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
-
G
--
E
G
R
A
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
H
----
S
L
N
A
E
P
W
A
Q
R
V
E
A
A
V
Q
R
V
L
D
Q
G
-
L
-
R
T
A
D
I
--
A
--
A
P
--
G
T
P
V
I
G
--
T
K
A
M
G
A
A
V
V
N
A
L
N
--------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
92.12
56%
-102
- C8 -
3VMK
5
?
A:
[15-371]
---------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
A
A
V
E
K
R
F
D
L
S
---
I
E
Y
S
E
Y
D
V
G
G
A
A
I
D
---
N
-
H
G
C
P
--
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
H
L
P
P
-
N
D
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
-
I
S
E
K
-
G
F
D
I
L
C
V
R
E
L
T
-------
G
G
I
Y
F
G
K
P
-------
K
-
G
R
Q
G
E
G
--
E
----
N
E
E
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
--
R
-------------
R
K
-------------
K
-
V
T
S
V
D
K
A
N
V
--
L
-
A
-
C
-
S
V
-
L
W
R
E
V
V
---
E
E
V
A
---
K
D
Y
--
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
S
--
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
----
S
L
K
L
E
D
A
A
L
A
I
E
A
A
V
S
K
A
L
S
D
G
-
Y
-
L
T
C
E
L
--
L
PA
S
E
--
R
S
Q
A
K
S
--
T
S
Q
M
G
D
Y
I
A
Q
A
I
---------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
91.73
59%
-101
- C8 -
3R8W
7
LEU32_ARATH
B:
[45-397]
----------------------
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
---
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
-
V
G
V
P
--
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
-
H
L
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
-
V
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
-------
G
G
I
Y
F
G
E
P
-------
R
G
I
K
T
N
E
N
--
G
----
E
E
V
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
--
R
-------------
R
G
-------------
K
-
L
C
S
V
D
K
A
N
V
--
L
-
E
-
A
-
S
I
-
L
W
R
K
R
V
---
T
A
L
A
---
S
E
Y
--
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
D
--
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
L
G
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
-
R
T
G
D
I
--
Y
--
S
A
--
G
T
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
---------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
91.57
55%
-105
- C8 -
3VMJ
3
LEU3_SHEON
A:
[15-372]
---------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
---
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
--
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
-
N
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
-------
G
G
I
Y
F
G
K
P
-------
K
-
G
R
Q
G
E
G
--
E
----
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
--
R
-------------
R
K
-------------
K
-
V
T
S
V
D
K
A
N
V
--
L
-
A
-
C
-
S
V
-
L
W
R
Q
V
V
---
E
E
V
A
---
V
D
F
--
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
--
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
L
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
-
L
T
G
E
L
--
L
--
S
S
--
D
Q
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
K
--------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
91.52
55%
-101
- C8 -
3VL6
3
LEU3_SHEON
A:
[15-372]
---------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
---
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
--
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
-
N
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
-------
G
G
I
Y
F
G
K
P
-------
K
-
G
R
Q
G
E
G
--
E
----
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
--
R
-------------
R
K
-------------
K
-
V
T
S
V
D
K
A
N
V
--
L
-
A
-
C
-
S
V
-
L
W
R
Q
V
V
---
E
E
V
A
---
V
D
F
--
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
--
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
L
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
-
L
T
G
E
L
--
L
--
S
S
--
D
Q
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
K
--------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
91.46
55%
-103
- C8 -
3VKZ
3
LEU3_SHEON
A:
[15-372]
---------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
---
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
--
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
-
N
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
-------
G
G
I
Y
F
G
K
P
-------
K
-
G
R
Q
G
E
G
--
E
----
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
--
R
-------------
R
K
-------------
K
-
V
T
S
V
D
K
A
N
V
--
L
-
A
-
C
-
S
V
-
L
W
R
Q
V
V
---
E
E
V
A
---
V
D
F
--
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
--
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
L
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
-
L
T
G
E
L
--
L
--
S
S
--
D
Q
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
K
--------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
91.41
56%
-105
- C8 -
3VML
3
LEU3_SHEON
A:
[15-372]
---------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
---
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
--
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
H
L
P
P
-
N
D
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
-
I
S
E
K
-
G
F
D
I
L
C
V
R
E
L
T
-------
G
G
I
Y
F
G
K
P
-------
K
-
G
R
Q
G
E
G
--
E
----
N
E
E
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
--
R
-------------
R
K
-------------
K
-
V
T
S
V
D
K
A
N
V
--
L
-
A
-
C
-
S
V
-
L
W
R
E
V
V
---
E
E
V
A
---
K
D
Y
--
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
S
--
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
----
S
L
K
L
E
D
A
A
L
A
I
E
A
A
V
S
K
A
L
N
S
G
-
Y
-
L
T
G
E
L
--
L
--
S
S
--
D
Q
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
K
--------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
91.37
56%
-103
- C8 -
3VMK
5
?
B:
[15-371]
---------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
A
A
V
E
K
R
F
D
L
S
---
I
E
Y
S
E
Y
D
V
G
G
A
A
I
D
---
N
-
H
G
C
P
--
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
H
L
P
P
-
N
D
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
-
I
S
E
K
-
G
F
D
I
L
C
V
R
E
L
T
-------
G
G
I
Y
F
G
K
P
-------
K
-
G
R
Q
G
E
G
--
E
----
N
E
E
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
--
R
-------------
R
K
-------------
K
-
V
T
S
V
D
K
A
N
V
--
L
-
A
-
C
-
S
V
-
L
W
R
E
V
V
---
E
E
V
A
---
K
D
Y
--
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
S
--
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
----
S
L
K
L
E
D
A
A
L
A
I
E
A
A
V
S
K
A
L
S
D
G
-
Y
-
L
T
C
E
L
--
L
PA
S
E
--
R
S
Q
A
K
S
--
T
S
Q
M
G
D
Y
I
A
Q
A
I
---------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
91.32
55%
-102
- C8 -
3VL7
3
LEU3_SHEON
A:
[15-372]
---------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
---
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
--
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
-
N
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
-------
G
G
I
Y
F
G
K
P
-------
K
-
G
R
Q
G
E
G
--
E
----
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
--
R
-------------
R
K
-------------
K
-
V
T
S
V
D
K
A
N
V
--
L
-
A
-
C
-
S
V
-
L
W
R
Q
V
V
---
E
E
V
A
---
V
D
F
--
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
--
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
L
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
-
L
T
G
E
L
--
L
--
S
S
--
D
Q
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
K
--------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
91.24
59%
-95
* C8 *
3R8W
5
LEU32_ARATH
A:
[41-398]
----------------
K
R
Y
--
T
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
---
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
-
V
G
V
P
--
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
-
H
L
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
-
V
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
-------
G
G
I
Y
F
G
E
P
-------
R
G
I
K
T
N
E
N
--
G
----
E
E
V
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
--
R
-------------
R
G
-------------
K
-
L
C
S
V
D
K
A
N
V
--
L
-
E
-
A
-
S
I
-
L
W
R
K
R
V
---
T
A
L
A
---
S
E
Y
--
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
D
--
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
L
G
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
-
R
T
G
D
I
--
Y
--
S
A
--
G
T
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
D
--------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
91.10
55%
-101
- C8 -
1CNZ
8
LEU3_SALTY
B:
[1-355]
----------------
M
S
K
NY
H
I
A
V
L
P
G
D
G
I
G
P
E
V
M
A
Q
A
L
K
V
M
D
A
V
R
S
R
F
D
M
R
---
I
T
T
S
H
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
H
P
--
L
P
K
A
T
V
E
G
C
E
-
Q
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
N
L
P
P
-
E
S
Q
P
E
R
G
A
L
L
P
L
R
K
H
F
K
L
F
S
N
L
R
P
A
K
L
Y
Q
G
L
E
A
F
C
P
L
R
A
D
-
I
A
-
A
N
G
F
D
I
L
C
V
R
E
L
T
-------
G
G
I
Y
F
G
Q
P
-------
K
G
R
E
G
S
G
Q
--
Y
----
E
K
-
A
F
D
T
E
V
Y
H
R
F
E
I
E
R
I
A
R
I
A
F
E
S
A
R
K
--
R
-------------
R
R
-------------
K
-
V
T
S
I
D
K
A
N
V
--
L
-
Q
-
S
-
S
I
-
L
W
R
E
I
V
---
N
D
V
A
---
K
T
Y
--
P
D
V
E
L
A
H
M
Y
I
D
N
A
T
M
Q
L
I
K
D
P
S
Q
F
D
V
L
L
C
S
N
L
F
G
D
I
L
S
D
E
C
A
M
I
T
G
S
M
G
M
L
P
S
A
S
L
N
E
--
Q
G
F
G
L
Y
E
P
A
G
G
S
A
P
D
I
A
G
K
N
I
A
N
P
I
A
Q
I
L
S
L
A
L
L
L
R
Y
----
S
L
D
A
N
D
A
A
T
A
I
E
Q
A
I
N
R
A
L
E
E
G
-
V
-
R
T
G
D
L
-----
A
R
--
G
A
A
A
V
S
--
T
D
E
M
G
D
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------
105
HHSearch
90.77
55%
-97
- C8 -
3VMK
5
?
A:
[13-373]
-----------------
S
Y
--
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
A
A
V
E
K
R
F
D
L
S
---
I
E
Y
S
E
Y
D
V
G
G
A
A
I
D
---
N
-
H
G
C
P
--
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
H
L
P
P
N
D
Q
P
E
R
G
A
-
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
I
S
E
-
K
-
G
F
D
I
L
C
V
R
E
L
T
-------
G
G
I
Y
F
G
K
P
-------
K
G
R
Q
G
-
E
G
--
E
----
N
E
E
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
--
R
-------------
R
K
-------------
K
-
V
T
S
V
D
K
A
N
V
--
L
-
A
-
C
-
S
V
-
L
W
R
E
V
V
---
E
E
V
A
---
K
D
Y
--
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
S
--
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
----
S
L
K
L
E
D
A
A
L
A
I
E
A
A
V
S
K
A
L
S
D
G
-
Y
-
L
T
C
E
L
--
L
--
P
A
SE
R
S
Q
A
K
S
--
T
S
Q
M
G
D
Y
I
A
Q
A
I
A
E
-------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
90.33
55%
-100
- C8 -
3VL3
3
LEU3_SHEON
A:
[15-372]
---------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
---
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
--
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
-
N
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
-------
G
G
I
Y
F
G
K
P
-------
K
-
G
R
Q
G
E
G
--
E
----
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
--
R
-------------
R
K
-------------
K
-
V
T
S
V
D
K
A
N
V
--
L
-
A
-
C
-
S
V
-
L
W
R
Q
V
V
---
E
E
V
A
---
V
D
F
--
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
--
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
L
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
-
L
T
G
E
L
--
L
--
S
S
--
D
Q
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
K
--------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
90.30
55%
-103
- C8 -
3VL2
3
LEU3_SHEON
A:
[15-372]
---------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
---
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
--
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
-
N
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
-------
G
G
I
Y
F
G
K
P
-------
K
-
G
R
Q
G
E
G
--
E
----
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
--
R
-------------
R
K
-------------
K
-
V
T
S
V
D
K
A
N
V
--
L
-
A
-
C
-
S
V
-
L
W
R
Q
V
V
---
E
E
V
A
---
V
D
F
--
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
--
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
L
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
-
L
T
G
E
L
--
L
--
S
S
--
D
Q
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
K
--------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
89.90
55%
-99
- C8 -
3VL4
3
LEU3_SHEON
A:
[15-372]
---------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
---
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
--
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
-
N
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
-------
G
G
I
Y
F
G
K
P
-------
K
-
G
R
Q
G
E
G
--
E
----
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
--
R
-------------
R
K
-------------
K
-
V
T
S
V
D
K
A
N
V
--
L
-
A
-
C
-
S
V
-
L
W
R
Q
V
V
---
E
E
V
A
---
V
D
F
--
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
--
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
L
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
-
L
T
G
E
L
--
L
--
S
S
--
D
Q
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
K
--------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
85.84
52%
-96
- C8 -
2Y3Z
7
LEU3_THET8
A:
[3-349]
-----------------
S
M
--
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
---
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
--
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
-
K
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
-------
G
G
I
Y
F
G
E
P
-------
R
G
-----
M
--
S
----
E
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
--
R
-------------
R
K
-------------
H
-
V
V
S
V
D
K
A
N
V
--
L
-
E
-
V
-
G
E
-
F
W
R
K
T
V
---
E
E
V
G
---
R
G
Y
--
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
---
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
F
G
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
L
E
--
T
-
P
P
P
D
L
--
G
--
G
------
S
A
G
--
T
E
A
F
T
A
T
V
L
R
H
L
A
A
-------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
83.34
53%
-96
- C8 -
4WUO
16
LEU3_THET8
A:
[3-322]
-----------------
S
M
--
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
---
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
--
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
-
K
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
-------
G
G
I
Y
F
G
E
P
-------
R
G
M
-------
S
----
E
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
--
R
-------------
R
K
-------------
H
-
V
V
S
V
D
K
A
N
V
--
L
-
E
-
V
-
G
E
-
F
W
R
K
T
V
---
E
E
V
G
---
R
G
Y
--
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
--
G
T
P
-
V
F
A
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
F
G
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
82.90
54%
-98
- C8 -
2Y3Z
7
LEU3_THET8
A:
[3-322]
-----------------
S
M
--
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
---
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
--
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
-
K
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
-------
G
G
I
Y
F
G
E
P
-------
R
G
M
-------
S
----
E
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
--
R
-------------
R
K
-------------
H
-
V
V
S
V
D
K
A
N
V
--
L
-
E
-
V
-
G
E
-
F
W
R
K
T
V
---
E
E
V
G
---
R
G
Y
--
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
--
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
F
G
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
82.69
54%
-100
- C8 -
1HEX
1
LEU3_THET8
A:
[2-319]
---------------------
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
---
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
--
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
-
K
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
-------
G
G
I
Y
F
G
E
P
-------
R
G
M
-------
S
----
E
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
--
R
-------------
R
K
-------------
H
-
V
V
S
V
D
K
A
N
V
--
L
-
E
-
V
-
G
E
-
F
W
R
K
T
V
---
E
E
V
G
---
R
G
Y
--
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
--
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
F
G
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
82.12
54%
-94
- C8 -
2Y41
4
LEU3_THET8
B:
[3-322]
-----------------
S
M
--
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
---
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
--
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
-
K
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
-------
G
G
I
Y
F
G
E
P
-------
R
G
M
-------
S
----
E
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
--
R
-------------
R
K
-------------
H
-
V
V
S
V
D
K
A
N
V
--
L
-
E
-
V
-
G
E
-
F
W
R
K
T
V
---
E
E
V
G
---
R
G
Y
--
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
--
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
F
G
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
81.68
54%
-95
- C8 -
2Y41
4
LEU3_THET8
A:
[3-322]
-----------------
S
M
--
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
---
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
--
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
-
K
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
-------
G
G
I
Y
F
G
E
P
-------
R
G
M
-------
S
----
E
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
--
R
-------------
R
K
-------------
H
-
V
V
S
V
D
K
A
N
V
--
L
-
E
-
V
-
G
E
-
F
W
R
K
T
V
---
E
E
V
G
---
R
G
Y
--
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
--
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
F
G
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
81.44
53%
-95
- C8 -
4WUO
9
LEU3_THET8
B:
[4-322]
------------------
M
--
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
---
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
--
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
-
K
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
-------
G
G
I
Y
F
G
E
P
-------
R
G
M
-------
S
----
E
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
--
R
-------------
R
K
-------------
H
-
V
V
S
V
D
K
A
N
V
--
L
-
E
-
V
-
G
E
-
F
W
R
K
T
V
---
E
E
V
G
---
R
G
Y
--
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
--
G
T
P
-
V
F
A
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
F
G
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
81.32
54%
-97
- C8 -
2ZTW
3
LEU3_THET8
A:
[2-319]
---------------------
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
---
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
--
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
-
K
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
-------
G
G
I
Y
F
G
E
P
-------
R
G
M
-------
S
----
E
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
--
R
-------------
R
K
-------------
H
-
V
V
S
V
D
K
A
N
V
--
L
-
E
-
V
-
G
E
-
F
W
R
K
T
V
---
E
E
V
G
---
R
G
Y
--
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
--
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
F
G
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
HHSearch
72.83
35%
-95
- C8 -
3TY4
5
LYS12_SCHPO
A:
[9-364]
----------------
R
R
I
--
V
L
G
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
E
N
L
P
A
K
H
K
L
K
---
F
D
F
I
D
L
D
A
G
W
G
T
F
E
---
R
-
T
G
K
A
--
L
P
E
R
T
V
E
R
L
K
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
T
H
K
V
-----
A
G
Y
S
S
P
-
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
D
G
A
K
----------
G
-
K
-
P
V
D
L
V
I
V
R
E
N
T
-------
E
C
L
Y
V
K
E
E
-------
R
M
V
Q
N
-
T
P
--
G
----
K
R
V
A
E
A
I
R
R
I
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
--
R
Q
K
I
R
E
S
GTYSIHK
K
P
-------------
L
-
V
T
I
I
H
K
S
N
V
--
M
-
S
-
V
T
D
G
-
L
F
R
E
S
C
---
R
H
A
Q
S
LD
P
S
Y
--
A
S
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
D
---
N
F
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
L
E
F
-----
M
G
H
Q
D
A
A
A
D
I
Y
T
A
V
D
K
V
L
T
E
G
K
V
-
L
T
P
D
L
--
G
--
G
------
K
S
G
--
T
N
E
I
T
D
A
V
L
A
N
I
---------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
71.15
33%
-90
- C8 -
3FMX
2
TTUC_PSEPU
X:
[5-363]
-----------------
S
F
--
R
I
A
A
I
P
G
D
G
I
G
L
E
V
L
P
E
G
I
R
V
L
E
A
A
A
L
K
H
G
L
A
---
L
E
F
--
D
T
F
E
W
A
S
C
D
YYL
Q
-
H
G
K
M
--
M
P
D
D
W
A
E
Q
L
K
-
Q
Y
D
A
I
Y
F
G
A
V
G
W
P
--
D
K
V
P
D
-
H
I
S
L
W
G
S
-
L
L
K
F
R
R
E
F
D
Q
Y
V
N
I
R
P
V
R
L
F
P
G
V
P
C
A
--
L
A
N
R
-
K
V
-
G
-
D
I
D
F
V
V
V
R
E
N
T
EGEYSSL
G
G
I
M
F
E
N
T
-------
E
N
E
I
V
I
Q
E
--
S
------------
I
F
T
R
R
G
V
D
R
I
L
K
Y
A
F
D
L
A
E
K
--
R
-------------
E
R
-------------
K
H
V
T
S
A
T
K
S
N
G
--
M
-
A
I
S
-
M
P
-
Y
W
D
K
R
T
---
E
A
M
A
---
A
H
Y
--
P
H
V
S
W
D
K
Q
H
I
D
I
L
C
A
R
F
V
L
Q
P
E
R
F
D
V
V
V
A
S
N
L
F
G
D
I
L
S
D
L
G
P
A
C
A
G
T
I
G
I
A
P
S
A
N
L
N
P
ER
N
F
P
S
L
F
E
P
V
H
G
S
A
P
D
I
F
G
K
N
I
A
N
P
I
A
M
I
W
S
G
A
L
M
L
E
F
LGQG
D
E
R
Y
Q
R
A
H
D
D
M
L
N
A
I
E
R
V
I
A
D
G
-
S
-
V
T
P
D
M
--
G
--
G
------
T
L
S
--
T
Q
Q
V
G
A
A
I
S
D
T
L
A
R
L
------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
70.29
34%
-90
- C8 -
3TY4
7
LYS12_SCHPO
B:
[15-364]
------------------------
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
E
N
L
P
A
K
H
K
L
K
---
F
D
F
I
D
L
D
A
G
W
G
T
F
E
---
R
-
T
G
K
A
--
L
P
E
R
T
V
E
R
L
K
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
T
H
-
K
V
A
G
-
Y
S
S
P
----
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
---
K
S
L
D
G
A
K
G
-
K
P
--------
V
D
L
V
I
V
R
E
N
T
-------
E
C
L
Y
V
----------
K
E
E
R
M
V
Q
N
TP
G
----
K
R
V
A
E
A
I
R
R
I
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
--
R
-------------
Q
K
I
R
E
S
G
T
Y
S
IHK
K
P
L
-
V
T
I
I
H
K
S
N
V
--
M
-
S
-
V
-
T
D
G
L
F
R
E
S
C
R
H
A
Q
S
L
D
---
P
S
Y
--
A
S
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
-
G
--
D
N
F
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
L
E
F
----
M
G
H
Q
D
A
A
A
D
-
I
Y
T
A
V
D
K
V
L
T
E
G
K
V
-
L
T
P
D
L
--
G
--
G
------
K
S
G
--
T
N
E
I
T
D
A
V
L
A
N
I
---------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
69.81
35%
-88
- C8 -
2D1C
4
IDH_THET8
B:
[20-355]
------------------
K
--
L
I
T
V
I
P
G
D
G
I
G
P
E
C
V
E
A
T
L
K
V
L
E
A
A
--
K
A
P
L
A
---
Y
E
V
R
E
---
A
G
A
S
V
F
---
R
-
R
G
I
A
SG
V
P
Q
E
T
I
E
S
I
R
-
K
T
R
V
V
L
K
G
P
L
E
T
P
V
-------
G
Y
G
E
K
S
A
-
N
V
T
L
R
K
L
F
E
T
Y
A
N
V
R
P
V
R
E
F
P
N
V
P
T
-----
P
Y
-
A
G
-
R
-
G
I
D
L
V
V
V
R
E
N
V
-------
E
D
L
Y
A
G
I
E
-------
H
M
Q
---
T
P
--
S
----
V
A
Q
T
L
K
L
I
S
W
K
G
S
E
--
K
I
V
R
F
A
F
E
L
A
R
A
EG
R
-------------
K
K
-------------
V
-
H
C
A
T
-
K
S
N
I
MK
L
-
A
-
E
-
G
T
-
L
K
R
-
A
F
---
E
Q
V
A
---
Q
E
Y
--
P
D
I
E
A
V
H
I
I
V
D
N
A
A
H
Q
L
V
K
R
P
E
Q
F
E
V
I
V
T
T
N
M
N
G
D
I
L
S
D
L
T
S
G
L
I
G
G
L
G
F
A
P
S
A
N
I
-
G
--
N
E
V
A
I
F
E
A
V
H
G
S
A
P
K
Y
A
G
K
N
V
I
N
P
T
A
V
L
L
S
A
V
M
M
L
R
Y
-----
L
E
E
F
A
T
A
D
L
I
E
N
A
L
L
Y
T
L
E
E
G
R
V
-
L
T
G
D
V
VG
Y
--
D
R
--
G
A
K
-----
T
T
E
Y
T
E
A
I
I
Q
N
L
---------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
68.94
34%
-83
- C8 -
3TY3
4
LYS12_SCHPO
A:
[15-366]
------------------------
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
E
N
L
P
A
K
H
K
L
K
---
F
D
F
I
D
L
D
A
G
W
G
T
F
E
---
R
-
T
G
K
A
--
L
P
E
R
T
V
E
R
L
K
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
T
H
-
K
V
A
G
-
Y
S
S
P
----
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
---
K
S
L
D
G
A
K
G
-
K
P
--------
V
D
L
V
I
V
R
E
N
T
-------
E
C
L
Y
V
----------
K
E
E
R
M
V
Q
N
TP
G
----
K
R
V
A
E
A
I
R
R
I
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
--
R
-------------
Q
K
I
R
E
S
G
T
Y
S
IHK
K
P
L
-
V
T
I
I
H
K
S
N
V
--
M
-
S
-
V
-
T
D
G
L
F
R
E
S
C
R
H
A
Q
S
L
D
---
P
S
Y
--
A
S
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
-
G
--
D
N
F
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
L
E
F
----
M
G
H
Q
D
A
A
A
D
-
I
Y
T
A
V
D
K
V
L
T
E
G
K
V
-
L
T
P
D
L
--
G
--
G
------
K
S
G
--
T
N
E
I
T
D
A
V
L
A
N
I
H
N
-------------------------------------------------------------------------------------------------------------------------------------------
90
Fugue
68.86
34%
-82
- C8 -
2D1C
4
IDH_THET8
A:
[2-496]
P
L
I
T
T
ETG
K
K
M
H
V
L
ED
G
R
K
--
L
I
T
V
I
P
G
D
G
I
G
P
E
C
V
E
A
T
L
K
V
L
E
A
A
K
----
A
P
---
L
A
Y
E
V
R
E
A
G
A
S
V
F
R
---
R
G
I
A
S
G
--
V
P
Q
E
T
I
E
S
I
R
-
K
T
R
V
V
L
K
G
P
L
E
T
P
V
G
Y
G
-------
E
K
S
A
-
N
V
T
L
R
K
L
F
E
T
Y
A
N
V
R
P
V
R
E
F
P
N
V
P
T
P
Y
A
G
R
--------
G
I
D
L
V
V
V
R
E
N
V
-------
E
D
L
Y
A
G
I
----------
E
H
M
Q
T
P
--
S
----
V
A
Q
T
L
K
L
I
--
S
W
K
G
S
E
K
I
V
R
F
A
F
E
L
A
R
A
--
E
-------------
G
R
K------------
K
-
V
H
C
A
T
K
S
N
I
--
M
K
L
-
A
-
E
G
-
T
L
K
R
A
F
---
E
Q
V
A
---
Q
E
Y
--
P
D
I
E
A
V
H
I
I
V
D
N
A
A
H
Q
L
V
K
R
P
E
Q
F
E
V
I
V
T
T
N
M
N
G
D
I
L
S
D
L
T
S
G
L
I
G
G
L
G
F
A
P
S
A
N
I
-
G
--
N
E
V
A
I
F
E
A
V
H
G
S
A
P
K
Y
A
G
K
N
V
I
N
P
T
A
V
L
L
S
A
V
M
M
L
R
Y
-----
L
E
E
F
A
T
A
D
L
I
E
N
A
L
L
Y
T
L
E
E
G
R
V
-
L
T
G
D
V
--
V
--
G
Y
--
D
-
R
G
A
K
--
T
T
E
Y
T
E
A
I
I
Q
N
L
G
K
T
PRKTQVRG
Y
K
P
F
R
L
PQVDGAIAPIVPR
S
R
R
V
V
G
V
D
V
F
V
E
T
NLL
P
E
A
L
G
K
A
L
E
D
L
A
AGTPFRLK
M
I
S
N
RGTQVYPPTGGL
T
D
L
V
D
H
Y
R
C
R
F
L
Y
TGEGEAK
D
P
E
I
L
D
L
V
S
R
V
A
S
R
F
R
W
M
H
L
E
K
L
Q
E
F
DGEPG
F
T
K
A
QGED
79
PsiBlast_CBE
68.68
34%
-85
- C8 -
3TY4
5
LYS12_SCHPO
A:
[15-364]
------------------------
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
E
N
L
P
A
K
H
K
L
K
---
F
D
F
I
D
L
D
A
G
W
G
T
F
E
---
R
-
T
G
K
A
--
L
P
E
R
T
V
E
R
L
K
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
T
H
-
K
V
A
G
-
Y
S
S
P
----
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
---
K
S
L
D
G
A
K
G
-
K
P
--------
V
D
L
V
I
V
R
E
N
T
-------
E
C
L
Y
V
----------
K
E
E
R
M
V
Q
N
TP
G
----
K
R
V
A
E
A
I
R
R
I
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
--
R
-------------
Q
K
I
R
E
S
GTYSIHK
K
P
L
-
V
T
I
I
H
K
S
N
V
--
M
-
S
-
V
-
T
D
G
L
F
R
E
S
C
R
H
A
Q
S
L
D
---
P
S
Y
--
A
S
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
-
G
--
D
N
F
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
L
E
F
----
M
G
H
Q
D
A
A
A
D
-
I
Y
T
A
V
D
K
V
L
T
E
G
K
V
-
L
T
P
D
L
--
G
--
G
------
K
S
G
--
T
N
E
I
T
D
A
V
L
A
N
I
---------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
68.61
35%
-83
- C8 -
2D1C
4
IDH_THET8
A:
[18-357]
----------------
G
R
K
--
L
I
T
V
I
P
G
D
G
I
G
P
E
C
V
E
A
T
L
K
V
L
E
A
A
----
K
A
P
---
L
A
Y
E
V
R
E
A
G
A
S
V
F
R
---
R
G
I
A
S
G
--
V
P
Q
E
T
I
E
S
I
R
-
K
T
R
V
V
L
K
G
P
L
E
T
P
V
G
Y
-------
G
E
K
S
A
-
N
V
T
L
R
K
L
F
E
T
Y
A
N
V
R
P
V
R
E
F
P
N
V
--
P
T
P
Y
A
----
G
-
R
-
G
I
D
L
V
V
V
R
E
N
V
-------
E
D
L
Y
A
G
I
E
-------
H
M
Q
T
-----------
P
S
V
A
Q
T
L
K
L
I
S
W
K
G
S
E
K
I
V
R
F
A
F
E
L
A
R
A
--
E
G------------
R
K
-------------
K
-
V
H
C
A
T
K
S
N
I
--
M
-
K
-
L
A
E
G
-
T
L
K
R
A
F
---
E
Q
V
A
---
Q
E
Y
--
P
D
I
E
A
V
H
I
I
V
D
N
A
A
H
Q
L
V
K
R
P
E
Q
F
E
V
I
V
T
T
N
M
N
G
D
I
L
S
D
L
T
S
G
L
I
G
G
L
G
F
A
P
S
A
N
I
G
N
---
E
V
A
I
F
E
A
V
H
G
S
A
P
K
Y
A
G
K
N
V
I
N
P
T
A
V
L
L
S
A
V
M
M
L
R
Y
-----
L
E
E
F
A
T
A
D
L
I
E
N
A
L
L
Y
T
L
E
E
G
-
R
V
L
T
G
D
V
--
V
--
G
Y
--
D
-
R
G
A
K
--
T
T
E
Y
T
E
A
I
I
Q
N
L
G
K
-------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
68.37
35%
-85
- C8 -
2D1C
4
IDH_THET8
A:
[20-355]
------------------
K
--
L
I
T
V
I
P
G
D
G
I
G
P
E
C
V
E
A
T
L
K
V
L
E
A
A
--
K
A
P
L
A
---
Y
E
V
R
E
---
A
G
A
S
V
F
---
R
-
R
G
I
A
SG
V
P
Q
E
T
I
E
S
I
R
-
K
T
R
V
V
L
K
G
P
L
E
T
P
V
-------
G
Y
G
E
K
S
A
-
N
V
T
L
R
K
L
F
E
T
Y
A
N
V
R
P
V
R
E
F
P
N
V
P
T
-----
P
Y
-
A
G
-
R
-
G
I
D
L
V
V
V
R
E
N
V
-------
E
D
L
Y
A
G
I
E
-------
H
M
Q
---
T
P
--
S
----
V
A
Q
T
L
K
L
I
S
W
K
G
S
E
--
K
I
V
R
F
A
F
E
L
A
R
A
E
G
R
-------------
K
K
-------------
V
-
H
C
A
T
-
K
S
N
I
MK
L
-
A
-
E
-
G
T
-
L
K
R
-
A
F
---
E
Q
V
A
---
Q
E
Y
--
P
D
I
E
A
V
H
I
I
V
D
N
A
A
H
Q
L
V
K
R
P
E
Q
F
E
V
I
V
T
T
N
M
N
G
D
I
L
S
D
L
T
S
G
L
I
G
G
L
G
F
A
P
S
A
N
I
-
G
--
N
E
V
A
I
F
E
A
V
H
G
S
A
P
K
Y
A
G
K
N
V
I
N
P
T
A
V
L
L
S
A
V
M
M
L
R
Y
-----
L
E
E
F
A
T
A
D
L
I
E
N
A
L
L
Y
T
L
E
E
G
R
V
-
L
T
G
D
V
VG
Y
--
D
R
--
G
A
K
-----
T
T
E
Y
T
E
A
I
I
Q
N
L
---------------------------------------------------------------------------------------------------------------------------------------------