@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3155: (2016-02-14 )
MIEFIDLKNQQARIKDKIDAGIQRVLRHGQYILGPEVTELEDRLADFVGAKYCISCANGTDALQIVQMALGVGPGDEVITPGFTYVATAETVALLGAKPVYVDIDPRTYNLDPQLLEAAITPRTKAIIPVSLYGQCADFDAINAIASKYGIPVIEDAAQSFGASYKGKRSCNLSTVACTSFFPSKPLGCYGDGGAIFTNDDELATAIRQIARHGQDRRYHHIRVGVNSRLDTLQAAILLPKLEIFEEEIALRQKVAAEYDLSLKQVGIGTPFIEVNNISVYAQYTVRMDNRESVQASLKAAGVPTAVHYPIPLNKQPAVADEKAKLPVGDKAATQVMSLPMHPYLDTASIKIICAALTN
Atome Classification :
(29 SA)
.........10........20........30----..--.......--40........50........60........70........80........90........100.......110.......120-------.......130.......140.......150.......160.......170.......180.......190.......200....----...210------------...----.-.---.--------------..220..---.....230.....---..240.......250.......-----260...-..----..270.-...-----...280---......---.-----.------290.......300-......---..310-.....------...320--.-----------------.---.....--.330.......340....-...350.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
E
F
IDLKN
Q
Q
A
R
I
K
D
K
I
D
A
G
I
Q
R
V
L
RHG
Q
-----
Y
I
--LGP
E
V
T
E
--
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
SCANG
T
D
A
L
Q
I
V
Q
M
A
LGVGPGDEVITPG
F
T
Y
V
A
T
A
E
T
V
A
LLGAK
P
V
Y
V
DIDPRTYNL
D
P
Q
L
L
E
A
AITP-------R
T
K
A
I
I
P
V
SLYGQCA
D
F
D
A
I
N
A
I
A
S
KYGI
P
V
I
E
D
A
A
Q
SFGASYKGKRSCN
L
S
T
V
A
CTSFFPSKPLGCYGDG
G
A
I
FTN
D
D
E
L
A
T
A
----
I
R
Q
I
A
-------------RHG----Q-D---R--------------
R
Y
H
H
I
R
V---GVNS
R
L
D
T
L
Q
A
A
I
---LL
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
EY-----DLS
L
K
Q-VG----IGT
P
F
I
-
E
VN-----
N
I
S
V
Y
----
A
Q
Y
T
V
R
---M-----D------
N
R
E
S
V
Q
A
S
L
K
A-A-GVP
T
A
V
---HYPI--PLNKQ------PAVAD---E-----------------K---AKLPV--G
D
K
A
A
T
Q
V
MSLPMHPYLD-TA
S
I
K
I
I
C
A
ALTN
22
PsiBlast_CBE
96.67
100%
-110
- C1 -
3NU7
5
WBPE_PSEAE
B:
[1-359]
M
I
E
F
I
D
L
K
N
Q
Q
A
R
I
K
D
K
I
D
A
G
I
Q
R
V
L
R
H
G
Q
-----
Y
I
--
L
G
P
E
V
T
E
--
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
-------
R
T
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
K
P
L
G
C
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
----
I
R
Q
I
A
-------------
R
H
G
----
Q
-
D
---
R
--------------
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
---
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
-----
D
L
S
L
K
Q
-
V
G
----
I
G
T
P
F
I
-
E
V
N
-----
N
I
S
V
Y
----
A
Q
Y
T
V
R
---
M
-----
D
------
N
R
E
S
V
Q
A
S
L
K
A
-
A
-
G
V
P
T
A
V
---
H
Y
P
I
--
P
L
N
K
Q
------
P
A
V
A
D
---
E
-----------------
K
---
A
K
L
P
V
--
G
D
K
A
A
T
Q
V
M
S
L
P
M
H
P
Y
L
D
-
T
A
S
I
K
I
I
C
A
A
L
T
N
104
HHSearch
96.09
100%
-110
- C1 -
3NYT
1
WBPE_PSEAE
A:
[1-359]
M
I
E
F
I
D
L
K
N
Q
Q
A
R
I
K
D
K
I
D
A
G
I
Q
R
V
L
R
H
G
Q
-----
Y
I
--
L
G
P
E
V
T
E
--
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
-------
R
T
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
A
P
L
G
C
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
----
I
R
Q
I
A
-------------
R
H
G
----
Q
-
D
---
R
--------------
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
---
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
-----
D
L
S
L
K
Q
-
V
G
----
I
G
T
P
F
I
-
E
V
N
-----
N
I
S
V
Y
----
A
Q
Y
T
V
R
---
M
-----
D
------
N
R
E
S
V
Q
A
S
L
K
A
-
A
-
G
V
P
T
A
V
---
H
Y
P
I
--
P
L
N
K
Q
------
P
A
V
A
D
---
E
-----------------
K
---
A
K
L
P
V
--
G
D
K
A
A
T
Q
V
M
S
L
P
M
H
P
Y
L
D
-
T
A
S
I
K
I
I
C
A
A
L
T
N
21
PsiBlast_CBE
96.07
100%
-109
- C1 -
3NUB
3
WBPE_PSEAE
B:
[1-358]
M
I
E
F
I
D
L
K
N
Q
Q
A
R
I
K
D
K
I
D
A
G
I
Q
R
V
L
R
H
G
Q
-----
Y
I
--
L
G
P
E
V
T
E
--
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
-------
R
T
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
K
P
L
G
C
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
----
I
R
Q
I
A
-------------
R
H
G
----
Q
-
D
---
R
--------------
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
---
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
-----
D
L
S
L
K
Q
-
V
G
----
I
G
T
P
F
I
-
E
V
N
-----
N
I
S
V
Y
----
A
Q
Y
T
V
R
---
M
-----
D
------
N
R
E
S
V
Q
A
S
L
K
A
-
A
-
G
V
P
T
A
V
---
H
Y
P
I
--
P
L
N
K
Q
------
P
A
V
A
D
---
E
-----------------
K
---
A
K
L
P
V
--
G
D
K
A
A
T
Q
V
M
S
L
P
M
H
P
Y
L
D
-
T
A
S
I
K
I
I
C
A
A
L
T
-
5
PsiBlast_PDB
95.88
99%
-110
- C1 -
3NYT
1
WBPE_PSEAE
A:
[1-359]
M
I
E
F
I
D
L
K
N
Q
Q
A
R
I
K
D
K
I
D
A
G
I
Q
R
V
L
R
H
G
Q
-----
Y
I
--
L
G
P
E
V
T
E
--
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
-------
R
T
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
A
P
L
G
C
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
----
I
R
Q
I
A
-------------
R
H
G
----
Q
-
D
---
R
--------------
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
---
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
-----
D
L
S
L
K
Q
-
V
G
----
I
G
T
P
F
I
-
E
V
N
-----
N
I
S
V
Y
----
A
Q
Y
T
V
R
---
M
-----
D
------
N
R
E
S
V
Q
A
S
L
K
A
-
A
-
G
V
P
T
A
V
---
H
Y
P
I
--
P
L
N
K
Q
------
P
A
V
A
D
---
E
-----------------
K
---
A
K
L
P
V
--
G
D
K
A
A
T
Q
V
M
S
L
P
M
H
P
Y
L
D
-
T
A
S
I
K
I
I
C
A
A
L
T
N
6
PsiBlast_PDB
95.58
99%
-108
- C1 -
3NYU
2
WBPE_PSEAE
A:
[1-359]
M
I
E
F
I
D
L
K
N
Q
Q
A
R
I
K
D
K
I
D
A
G
I
Q
R
V
L
R
H
G
Q
-----
Y
I
--
L
G
P
E
V
T
E
--
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
-------
R
T
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
K
P
L
G
C
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
----
I
R
Q
I
A
-------------
R
H
G
----
Q
-
D
---
R
--------------
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
---
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
-----
D
L
S
L
K
Q
-
V
G
----
I
G
T
P
F
I
-
E
V
N
-----
N
I
S
V
Y
----
A
Q
Y
T
V
R
---
M
-----
D
------
N
R
E
S
V
Q
A
S
L
K
A
-
A
-
G
V
P
T
A
V
---
H
Y
P
I
--
P
L
N
K
Q
------
P
A
V
A
D
---
E
-----------------
K
---
A
K
L
P
V
--
G
D
K
A
A
T
Q
V
M
S
L
P
M
H
P
Y
L
D
-
T
A
S
I
K
I
I
C
A
A
L
T
N
1
PsiBlast_PDB
95.13
100%
-109
- C1 -
3NU7
4
WBPE_PSEAE
A:
[2-359]
-
I
E
F
I
D
L
K
N
Q
Q
A
R
I
K
D
K
I
D
A
G
I
Q
R
V
L
R
H
G
Q
-----
Y
I
--
L
G
P
E
V
T
E
--
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
-------
R
T
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
K
P
L
G
C
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
----
I
R
Q
I
A
-------------
R
H
G
----
Q
-
D
---
R
--------------
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
---
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
-----
D
L
S
L
K
Q
-
V
G
----
I
G
T
P
F
I
-
E
V
N
-----
N
I
S
V
Y
----
A
Q
Y
T
V
R
---
M
-----
D
------
N
R
E
S
V
Q
A
S
L
K
A
-
A
-
G
V
P
T
A
V
---
H
Y
P
I
--
P
L
N
K
Q
------
P
A
V
A
D
---
E
-----------------
K
---
A
K
L
P
V
--
G
D
K
A
A
T
Q
V
M
S
L
P
M
H
P
Y
L
D
-
T
A
S
I
K
I
I
C
A
A
L
T
N
4
PsiBlast_PDB
95.11
99%
-109
- C1 -
3NYS
1
WBPE_PSEAE
A:
[1-359]
M
I
E
F
I
D
L
K
N
Q
Q
A
R
I
K
D
K
I
D
A
G
I
Q
R
V
L
R
H
G
Q
-----
Y
I
--
L
G
P
E
V
T
E
--
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
-------
R
T
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
A
P
L
G
C
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
----
I
R
Q
I
A
-------------
R
H
G
----
Q
-
D
---
R
--------------
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
---
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
-----
D
L
S
L
K
Q
-
V
G
----
I
G
T
P
F
I
-
E
V
N
-----
N
I
S
V
Y
----
A
Q
Y
T
V
R
---
M
-----
D
------
N
R
E
S
V
Q
A
S
L
K
A
-
A
-
G
V
P
T
A
V
---
H
Y
P
I
--
P
L
N
K
Q
------
P
A
V
A
D
---
E
-----------------
K
---
A
K
L
P
V
--
G
D
K
A
A
T
Q
V
M
S
L
P
M
H
P
Y
L
D
-
T
A
S
I
K
I
I
C
A
A
L
T
N
24
PsiBlast_CBE
94.82
99%
-107
- C1 -
3NYU
4
WBPE_PSEAE
B:
[2-358]
-
I
E
F
I
D
L
K
N
Q
Q
A
R
I
K
D
K
I
D
A
G
I
Q
R
V
L
R
H
G
Q
-----
Y
I
--
L
G
P
E
V
T
E
--
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
-------
R
T
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
K
P
L
G
C
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
----
I
R
Q
I
A
-------------
R
H
G
----
Q
-
D
---
R
--------------
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
---
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
-----
D
L
S
L
K
Q
-
V
G
----
I
G
T
P
F
I
-
E
V
N
-----
N
I
S
V
Y
----
A
Q
Y
T
V
R
---
M
-----
D
------
N
R
E
S
V
Q
A
S
L
K
A
-
A
-
G
V
P
T
A
V
---
H
Y
P
I
--
P
L
N
K
Q
------
P
A
V
A
D
---
E
-----------------
K
---
A
K
L
P
V
--
G
D
K
A
A
T
Q
V
M
S
L
P
M
H
P
Y
L
D
-
T
A
S
I
K
I
I
C
A
A
L
T
-
23
PsiBlast_CBE
94.30
99%
-110
- C1 -
3NYU
1
WBPE_PSEAE
C:
[2-358]
-
I
E
F
I
D
L
K
N
Q
Q
A
R
I
K
D
K
I
D
A
G
I
Q
R
V
L
R
H
G
Q
-----
Y
I
--
L
G
P
E
V
T
E
--
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
-------
R
T
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
K
P
L
G
C
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
----
I
R
Q
I
A
-------------
R
H
G
----
Q
-
D
---
R
--------------
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
---
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
-----
D
L
S
L
K
Q
-
V
G
----
I
G
T
P
F
I
-
E
V
N
-----
N
I
S
V
Y
----
A
Q
Y
T
V
R
---
M
-----
D
------
N
R
E
S
V
Q
A
S
L
K
A
-
A
-
G
V
P
T
A
V
---
H
Y
P
I
--
P
L
N
K
Q
------
P
A
V
A
D
---
E
-----------------
K
---
A
K
L
P
V
--
G
D
K
A
A
T
Q
V
M
S
L
P
M
H
P
Y
L
D
-
T
A
S
I
K
I
I
C
A
A
L
T
-
2
PsiBlast_PDB
94.26
100%
-107
- C1 -
3NUB
4
WBPE_PSEAE
A:
[1-358]
M
I
E
F
I
D
L
K
N
Q
Q
A
R
I
K
D
K
I
D
A
G
I
Q
R
V
L
R
H
G
Q
-----
Y
I
--
L
G
P
E
V
T
E
--
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
-------
R
T
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
K
P
L
G
C
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
----
I
R
Q
I
A
-------------
R
H
G
----
Q
-
D
---
R
--------------
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
---
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
-----
D
L
S
L
K
Q
-
V
G
----
I
G
T
P
F
I
-
E
V
N
-----
N
I
S
V
Y
----
A
Q
Y
T
V
R
---
M
-----
D
------
N
R
E
S
V
Q
A
S
L
K
A
-
A
-
G
V
P
T
A
V
---
H
Y
P
I
--
P
L
N
K
Q
------
P
A
V
A
D
---
E
-----------------
K
---
A
K
L
P
V
--
G
D
K
A
A
T
Q
V
M
S
L
P
M
H
P
Y
L
D
-
T
A
S
I
K
I
I
C
A
A
L
T
-
7
PsiBlast_PDB
77.85
46%
-95
- C1 -
4QGR
5
?
A:
[9-365]
-
M
Q
F
I
D
L
G
A
Q
R
A
R
I
E
N
R
L
N
A
A
I
S
K
V
V
A
E
G
R
-----
Y
I
--
L
G
P
E
V
A
E
--
F
E
K
K
L
G
E
Y
L
G
V
E
H
V
I
A
C
A
N
G
T
D
A
L
Q
M
P
L
M
T
R
G
I
G
P
G
H
A
V
F
V
P
S
F
T
F
A
A
T
A
E
V
V
A
L
V
G
A
E
P
V
F
V
D
V
D
P
D
S
Y
N
M
N
V
E
Q
L
E
A
A
I
A
A
T
I
K
E
GR
L
E
P
K
A
I
I
P
V
D
L
F
G
L
A
A
S
Y
N
R
I
T
A
I
A
E
R
E
G
L
F
I
I
E
D
A
A
Q
S
I
G
G
K
R
D
N
V
M
C
G
A
F
G
H
V
G
A
T
S
F
Y
P
A
K
P
L
G
C
Y
G
D
G
G
A
M
F
T
N
D
A
E
L
A
D
T
----
L
R
S
V
L
-------------
F
H
G
----
K
G
E
---
T
--------------
Q
Y
D
N
V
R
I
---
G
I
N
S
R
L
D
T
I
Q
A
A
V
---
L
L
E
K
L
A
I
L
E
D
E
M
E
A
R
D
R
I
A
R
R
Y
-----
N
E
A
L
K
D
-
V
-----
V
K
V
P
E
L
-
P
A
G
-----
N
R
S
A
W
----
A
Q
Y
S
I
E
---
S
-----
E
------
N
R
D
G
L
K
A
Q
L
Q
A
-
E
-
G
I
P
S
V
I
---
Y
Y
V
K
--
P
L
H
L
Q
------
T
A
Y
K
H
---
Y
-----------------
S
V
A
P
G
G
L
P
V
--
S
E
S
L
P
S
R
I
L
S
L
P
M
H
P
Y
L
S
-
E
A
-----------
25
PsiBlast_CBE
77.54
46%
-96
- C1 -
4QGR
4
?
B:
[9-365]
-
M
Q
F
I
D
L
G
A
Q
R
A
R
I
E
N
R
L
N
A
A
I
S
K
V
V
A
E
G
R
-----
Y
I
--
L
G
P
E
V
A
E
--
F
E
K
K
L
G
E
Y
L
G
V
E
H
V
I
A
C
A
N
G
T
D
A
L
Q
M
P
L
M
T
R
G
I
G
P
G
H
A
V
F
V
P
S
F
T
F
A
A
T
A
E
V
V
A
L
V
G
A
E
P
V
F
V
D
V
D
P
D
S
Y
N
M
N
V
E
Q
L
E
A
A
I
A
A
T
I
K
E
GR
L
E
P
K
A
I
I
P
V
D
L
F
G
L
A
A
S
Y
N
R
I
T
A
I
A
E
R
E
G
L
F
I
I
E
D
A
A
Q
S
I
G
G
K
R
D
N
V
M
C
G
A
F
G
H
V
G
A
T
S
F
Y
P
A
K
P
L
G
C
Y
G
D
G
G
A
M
F
T
N
D
A
E
L
A
D
T
----
L
R
S
V
L
-------------
F
H
G
----
K
G
E
---
T
--------------
Q
Y
D
N
V
R
I
---
G
I
N
S
R
L
D
T
I
Q
A
A
V
---
L
L
E
K
L
A
I
L
E
D
E
M
E
A
R
D
R
I
A
R
R
Y
-----
N
E
A
L
K
D
-
V
-----
V
K
V
P
E
L
-
P
A
G
-----
N
R
S
A
W
----
A
Q
Y
S
I
E
---
S
-----
E
------
N
R
D
G
L
K
A
Q
L
Q
A
-
E
-
G
I
P
S
V
I
---
Y
Y
V
K
--
P
L
H
L
Q
------
T
A
Y
K
H
---
Y
-----------------
S
V
A
P
G
G
L
P
V
--
S
E
S
L
P
S
R
I
L
S
L
P
M
H
P
Y
L
S
-
E
A
-----------
15
PsiBlast_PDB
75.39
34%
-110
- C1 -
1MDX
4
ARNB_SALTY
A:
[24-379]
-------------------
A
A
V
K
T
V
L
D
S
G
W
-----
I
T
--
T
G
P
K
N
Q
E
--
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
A
L
G
I
G
E
G
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
E
A
A
I
T
P
-------
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
-
R
H
I
G
A
R
G
T
A
I
F
S
F
H
A
I
K
N
I
T
C
-
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
----
L
R
S
L
K
-------------
F
H
G
L----------G-------------
R
A
P
Q
A
E
V
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
---
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
-----
H
Q
A
M
A
D
-
L
--------
P
F
Q
-
P
L
S
LPS
W
E
H
I
H
A
W
----
H
L
F
I
I
R
---
V
-----
D
EARCGI
T
R
D
A
L
M
A
S
L
K
T
-
K
-
G
I
G
T
G
L
---
H
F
R
A
--
A
H
T
Q
K
Y
Y
R
E
R
F
P
T
L
----------------------------
T
L
P
D
--
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
M
T
-
E
S
D
F
D
R
V
I
T
A
L
--
31
PsiBlast_CBE
75.18
41%
-106
- C1 -
3DR4
2
GDPPS_CAUCR
C:
[54-386]
---------------------------------------
V
G
R
F
I
V
E
--
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
A
M
G
I
G
P
G
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
P
-------
R
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
-
T
T
G
E
G
G
M
I
T
T
N
D
D
D
L
A
A
K
----
M
R
L
L
R
-------------
G
Q
G
----
M
-
D
PN-
R
--------------
R
Y
W
F
P
I
V
---
G
F
N
Y
R
M
T
N
I
Q
A
A
I
---
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
-----
E
Q
K
L
A
R
-
L
G
NR--
V
T
K
P
H
V
-
A
L
T
-----
G
R
H
V
F
----
W
M
Y
T
V
R
---
L
GEGLS
T
------
T
R
D
Q
V
I
K
D
L
D
A
-
L
-
G
I
E
S
R
------
P
V
FH
P
M
H
I
M
------
P
P
Y
A
H
L--
A
-----------------
T
---
D
D
L
K
I
--
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
T
-
E
A
D
I
D
R
V
I
A
A
L
--
16
PsiBlast_PDB
75.11
34%
-110
- C1 -
1MDZ
1
ARNB_SALTY
A:
[24-379]
-------------------
A
A
V
K
T
V
L
D
S
G
W
-----
I
T
--
T
G
P
K
N
Q
E
--
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
A
L
G
I
G
E
G
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
E
A
A
I
T
P
-------
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
-
R
H
I
G
A
R
G
T
A
I
F
S
F
H
A
I
K
N
I
T
C
-
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
----
L
R
S
L
K
-------------
F
H
G
LGVD------------------------
Q
A
E
V
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
---
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
-----
H
Q
A
M
A
D
-
L
--------
P
F
Q
-
P
L
S
LPS
W
E
H
I
H
A
W
----
H
L
F
I
I
R
---
V
-----
D
EARCGI
T
R
D
A
L
M
A
S
L
K
T
-
K
-
G
I
G
T
G
L
---
H
F
R
A
--
A
H
T
Q
K
Y
Y
R
E
R
F
P
T
L
----------------------------
T
L
P
D
--
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
M
T
-
E
S
D
F
D
R
V
I
T
A
L
--
3
PsiBlast_PDB
75.11
99%
-72
- C1 -
3NU8
-
WBPE_PSEAE
A:
[1-358]
M
I
E
F
I
D
L
K
N
Q
Q
A
R
I
K
D
K
I
D
A
G
I
Q
R
V
L
R
H
G
Q
-----
Y
I
--
L
G
P
E
V
T
E
--
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
-------
R
T
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
K
P
L
G
C
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
----
I
R
Q
I
A
-------------
R
H
G
----
Q
-
D
---
R
--------------
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
---
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
-----
D
L
S
L
K
Q
-
V
G
----
I
G
T
P
F
I
-
E
V
N
-----
N
I
S
V
Y
----
A
Q
Y
T
V
R
---
M
-----
D
------
N
R
E
S
V
Q
A
S
L
K
A
-
A
-
G
V
P
T
A
V
---
H
Y
P
I
--
P
L
N
K
Q
------
P
A
V
A
D
---
E
-----------------
K
---
A
K
L
P
V
--
G
D
K
A
A
T
Q
V
M
S
L
P
M
H
P
Y
L
D
-
T
A
S
I
K
I
I
C
A
A
L
T
-
106
HHSearch
75.03
41%
-95
- C1 -
2OGA
7
DESV_STRVZ
A:
[30-391]
-
V
P
F
L
D
L
K
A
A
Y
E
E
L
R
A
E
T
D
A
A
I
A
R
V
L
D
S
G
R
-----
Y
L
--
L
G
P
E
L
E
G
--
F
E
A
E
F
A
A
Y
C
E
T
D
H
A
V
G
V
N
S
G
M
D
A
L
Q
L
A
L
R
G
L
G
I
G
P
G
D
E
V
I
V
P
S
H
T
Y
I
A
S
W
L
A
V
S
A
T
G
A
T
P
V
P
V
E
P
H
E
D
H
P
T
L
D
P
L
L
V
E
K
A
I
T
P
-------
R
T
R
A
L
L
P
V
H
L
Y
G
H
P
A
D
M
D
A
L
R
E
L
A
D
R
H
G
L
H
I
V
E
D
A
A
Q
A
H
G
A
R
Y
R
G
R
R
I
G
A
G
S
S
V
A
A
F
S
F
Y
P
G
K
N
L
G
C
F
G
D
G
G
A
V
V
T
G
D
P
E
L
A
E
R
----
L
R
M
L
R
-------------
N
Y
G
----
S
-
R
---
Q
--------------
K
Y
S
H
E
T
K
---
G
T
N
S
R
L
D
E
M
Q
A
A
V
---
L
R
I
R
L
A
H
L
D
S
W
N
G
R
R
S
A
L
A
A
E
Y
-----
L
S
G
L
A
G
L
P
G
----
I
G
L
P
V
T
-
A
P
D
-----
T
D
P
V
W
----
H
L
F
T
V
R
---
T
-----
E
------
R
R
D
E
L
R
S
H
L
D
A
-
R
-
G
I
D
T
L
T
---
H
Y
P
V
--
P
V
H
L
S
------
P
A
Y
A
G
---
E
APP--------------
E
---
G
S
L
P
R
--
A
E
S
F
A
R
Q
V
L
S
L
P
I
G
P
H
L
E
-
R
P
Q
A
L
R
V
I
D
A
V
R
E
105
HHSearch
74.98
39%
-99
- C1 -
3FRK
2
?
A:
[2-363]
K
I
S
F
A
S
F
K
P
M
H
D
E
I
E
Y
E
I
K
F
K
F
E
E
I
Y
K
R
N
W
-----
F
I
--
L
G
D
E
D
K
K
--
F
E
Q
E
F
A
D
Y
C
N
V
N
Y
C
I
G
C
G
N
G
L
D
A
L
H
L
I
L
K
G
Y
D
I
G
F
G
D
E
V
I
V
P
S
N
T
F
I
A
T
A
L
A
V
S
Y
T
G
A
K
P
I
F
V
E
P
D
I
R
T
Y
N
I
D
P
S
L
I
E
S
A
I
T
E
-------
K
T
K
A
I
I
A
V
H
L
Y
G
Q
P
A
D
M
D
E
I
K
R
I
A
K
K
Y
N
L
K
L
I
E
D
A
A
Q
A
H
G
S
L
Y
K
G
M
K
V
G
S
L
G
D
A
A
G
F
S
F
Y
P
A
K
N
L
G
S
L
G
D
G
G
A
V
V
T
N
D
K
D
L
A
E
K
----
I
K
A
L
S
-------------
N
Y
G
----
S
-
E
---
K
--------------
K
Y
H
H
I
Y
K
---
G
F
N
S
R
L
D
E
L
Q
A
G
F
---
L
R
V
K
L
K
Y
L
D
K
W
N
E
E
R
R
K
I
A
Q
K
Y
-----
I
A
G
I
N
N
-
P
N
----
V
I
I
P
V
E
-
A
D
Y
-----
A
K
H
V
W
----
Y
T
F
V
I
R
---
S
-----
E
------
K
R
D
E
L
Q
K
Y
L
N
N
-
N
-
G
I
G
T
L
I
---
H
Y
P
I
--
P
I
H
L
Q
------
Q
A
Y
K
D
---
L
GFK--------------
T
---
G
N
F
P
I
--
A
E
K
I
A
N
E
I
L
S
I
P
I
W
Y
G
M
K
-
N
E
E
I
E
Y
V
I
D
K
I
N
A
11
PsiBlast_PDB
74.79
41%
-106
- C1 -
3DR4
2
GDPPS_CAUCR
A:
[54-386]
---------------------------------------
V
G
R
F
I
V
E
--
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
A
M
G
I
G
P
G
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
P
-------
R
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
-
T
T
G
E
G
G
M
I
T
T
N
D
D
D
L
A
A
K
----
M
R
L
L
R
-------------
G
Q
G
----
M
-
D
PN-
R
--------------
R
Y
W
F
P
I
V
---
G
F
N
Y
R
M
T
N
I
Q
A
A
I
---
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
-----
E
Q
K
L
A
R
-
L
G
NR--
V
T
K
P
H
V
-
A
L
T
-----
G
R
H
V
F
----
W
M
Y
T
V
R
---
L
G
EGLS
T
------
T
R
D
Q
V
I
K
D
L
D
A
-
L
-
G
I
E
S
R
------
P
V
FH
P
M
H
I
M
------
P
P
Y
A
H
L--
A
-----------------
T
---
D
D
L
K
I
--
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
T
-
E
A
D
I
D
R
V
I
A
A
L
--
32
PsiBlast_CBE
74.73
41%
-106
- C1 -
3DR4
4
GDPPS_CAUCR
B:
[54-386]
---------------------------------------
V
G
R
F
I
V
E
--
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
A
M
G
I
G
P
G
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
P
-------
R
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
-
T
T
G
E
G
G
M
I
T
T
N
D
D
D
L
A
A
K
----
M
R
L
L
R
-------------
G
Q
G
----
M
-
D
PN-
R
--------------
R
Y
W
F
P
I
V
---
G
F
N
Y
R
M
T
N
I
Q
A
A
I
---
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
-----
E
Q
K
L
A
R
-
L
G
NR--
V
T
K
P
H
V
-
A
L
T
-----
G
R
H
V
F
----
W
M
Y
T
V
R
---
L
GEGLS
T
------
T
R
D
Q
V
I
K
D
L
D
A
-
L
-
G
I
E
S
R
------
P
V
FH
P
M
H
I
M
------
P
P
Y
A
H
L--
A
-----------------
T
---
D
D
L
K
I
--
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
T
-
E
A
D
I
D
R
V
I
A
A
L
--
10
PsiBlast_PDB
74.29
39%
-97
- C1 -
3FRK
2
?
A:
[3-357]
-
I
S
F
A
S
F
K
P
M
H
D
E
I
E
Y
E
I
K
F
K
F
E
E
I
Y
K
R
N
W
-----
F
I
--
L
G
D
E
D
K
K
--
F
E
Q
E
F
A
D
Y
C
N
V
N
Y
C
I
G
C
G
N
G
L
D
A
L
H
L
I
L
K
G
Y
D
I
G
F
G
D
E
V
I
V
P
S
N
T
F
I
A
T
A
L
A
V
S
Y
T
G
A
K
P
I
F
V
E
P
D
I
R
T
Y
N
I
D
P
S
L
I
E
S
A
I
T
E
-------
K
T
K
A
I
I
A
V
H
L
Y
G
Q
P
A
D
M
D
E
I
K
R
I
A
K
K
Y
N
L
K
L
I
E
D
A
A
Q
A
H
G
S
L
Y
K
G
M
K
V
G
S
L
G
D
A
A
G
F
S
F
Y
P
A
K
N
L
G
S
L
G
D
G
G
A
V
V
T
N
D
K
D
L
A
E
K
----
I
K
A
L
S
-------------
N
Y
G
----
S
-
E
---
K
--------------
K
Y
H
H
I
Y
K
---
G
F
N
S
R
L
D
E
L
Q
A
G
F
---
L
R
V
K
L
K
Y
L
D
K
W
N
E
E
R
R
K
I
A
Q
K
Y
-----
I
A
G
I
N
N
-
P
N
----
V
I
I
P
V
E
-
A
D
Y
-----
A
K
H
V
W
----
Y
T
F
V
I
R
---
S
-----
E
------
K
R
D
E
L
Q
K
Y
L
N
N
-
N
-
G
I
G
T
L
I
---
H
Y
P
I
--
P
I
H
L
Q
------
Q
A
Y
K
D
LGF
K
-----------------
T
---
G
N
F
P
I
--
A
E
K
I
A
N
E
I
L
S
I
P
I
W
Y
G
M
K
-
N
E
E
I
E
Y
V
------
29
PsiBlast_CBE
73.37
39%
-94
- C1 -
3FRK
2
?
B:
[3-357]
-
I
S
F
A
S
F
K
P
M
H
D
E
I
E
Y
E
I
K
F
K
F
E
E
I
Y
K
R
N
W
-----
F
I
--
L
G
D
E
D
K
K
--
F
E
Q
E
F
A
D
Y
C
N
V
N
Y
C
I
G
C
G
N
G
L
D
A
L
H
L
I
L
K
G
Y
D
I
G
F
G
D
E
V
I
V
P
S
N
T
F
I
A
T
A
L
A
V
S
Y
T
G
A
K
P
I
F
V
E
P
D
I
R
T
Y
N
I
D
P
S
L
I
E
S
A
I
T
E
-------
K
T
K
A
I
I
A
V
H
L
Y
G
Q
P
A
D
M
D
E
I
K
R
I
A
K
K
Y
N
L
K
L
I
E
D
A
A
Q
A
H
G
S
L
Y
K
G
M
K
V
G
S
L
G
D
A
A
G
F
S
F
Y
P
A
K
N
L
G
S
L
G
D
G
G
A
V
V
T
N
D
K
D
L
A
E
K
----
I
K
A
L
S
-------------
N
Y
G
----
S
-
E
---
K
--------------
K
Y
H
H
I
Y
K
---
G
F
N
S
R
L
D
E
L
Q
A
G
F
---
L
R
V
K
L
K
Y
L
D
K
W
N
E
E
R
R
K
I
A
Q
K
Y
-----
I
A
G
I
N
N
-
P
N
----
V
I
I
P
V
E
-
A
D
Y
-----
A
K
H
V
W
----
Y
T
F
V
I
R
---
S
-----
E
------
K
R
D
E
L
Q
K
Y
L
N
N
-
N
-
G
I
G
T
L
I
---
H
Y
P
I
--
P
I
H
L
Q
------
Q
A
Y
K
D
LGF
K
-----------------
T
---
G
N
F
P
I
--
A
E
K
I
A
N
E
I
L
S
I
P
I
W
Y
G
M
K
-
N
E
E
I
E
Y
V
------
17
PsiBlast_PDB
69.09
33%
-95
- C1 -
3UWC
6
?
A:
[11-360]
------
L
E
R
Q
F
A
D
I
E
P
Y
L
N
-
D
L
R
E
F
I
K
T
A
D
-----
F
T
--
L
G
A
E
L
E
K
--
F
E
K
R
F
A
A
L
H
N
A
P
H
A
I
G
V
G
T
G
T
D
A
L
A
M
S
F
K
M
L
N
I
G
A
G
D
E
V
I
T
C
A
N
T
F
I
A
S
V
G
A
I
V
Q
A
G
A
T
P
V
L
V
D
S
E
-
N
G
Y
V
I
D
P
E
K
I
E
A
A
I
T
D
-------
K
T
K
A
I
M
P
V
H
Y
T
G
N
I
A
D
M
P
A
L
A
K
I
A
K
K
H
N
L
H
I
V
E
D
A
C
Q
T
I
L
G
R
I
N
D
K
F
V
G
S
W
G
Q
F
A
C
F
S
L
H
P
L
K
N
L
N
V
W
S
D
A
G
V
I
I
T
H
S
D
E
Y
A
E
K
----
L
R
L
Y
R
-------------
N
H
G
----
L
-
I
---
N
--------------
R
D
V
C
V
E
Y
---
G
I
N
C
R
M
D
T
I
Q
A
V
I
A
N
R
L
M
N
Q
L
E
T
I
T
E
K
---
R
R
G
I
A
H
L
Y
-----
D
Q
S
F
V
D
-
L
S
EF--
I
D
V
P
V
R
-
R
E
G
-----
V
Y
H
V
F
----
H
I
Y
V
L
R
---
V
-----
K
------
Y
R
D
Q
L
F
Q
Y
L
K
D
-
N
-
G
I
E
V
K
I
---
H
Y
P
I
--
A
M
H
L
Q
------
P
A
A
K
S
LGY
Q
-----------------
Q
---
G
D
F
P
M
--
A
E
K
H
G
E
A
V
I
T
L
P
A
H
P
Y
L
T
-
E
E
E
I
N
Y
I
------
113
HHSearch
68.07
31%
-96
- C1 -
2C81
1
GLDSA_BACCI
A:
[12-409]
-----------
P
Q
H
S
D
R
T
R
R
K
I
E
E
V
F
Q
S
N
R
WAISG
Y
W
TG
E
E
S
M
E
R
K
--
F
A
K
A
F
A
D
F
N
G
V
P
Y
C
V
P
T
T
S
G
S
T
A
L
M
L
A
L
E
A
L
G
I
G
E
G
D
E
V
I
V
P
S
L
T
W
I
A
T
A
T
A
V
L
N
V
N
A
L
P
V
F
V
D
V
E
A
D
T
Y
C
I
D
P
Q
L
I
K
S
A
I
T
D
-------
K
T
K
A
I
I
P
V
H
L
F
G
S
M
A
N
M
D
E
I
N
E
I
A
Q
E
H
N
L
F
V
I
E
D
C
A
Q
S
H
G
S
V
W
N
N
Q
R
A
G
T
I
G
D
I
G
A
F
S
C
Q
Q
G
K
V
L
T
-
A
G
E
G
G
I
I
V
T
K
N
P
R
L
F
E
L
----
I
Q
Q
L
R
-------------
A
D
S
----
R
-
V
---
Y
CDDSSELMHGDMQ
L
V
K
K
G
D
I
Q
---
G
S
N
Y
C
L
S
E
F
Q
S
A
I
---
L
L
D
Q
L
Q
E
L
D
D
K
N
A
I
R
E
K
N
A
M
F
L
-----
N
D
A
L
S
K
I
D
G
----
I
K
V
M
K
R
P
P
Q
V
-----
S
R
Q
T
Y
Y
G
Y
V
F
R
F
D
P
V
KFG
G
-----
L
------
N
A
D
Q
F
C
E
I
L
R
E
-
K
L
N
M
G
T
F
Y
L
H
P
P
Y
-
L
--
P
V
H
K
N
------
P
L
F
C
P
---
W
TKNRYLKSVRKT
E
A
Y
W
R
G
---
L
H
Y
P
V
--
S
E
R
A
S
G
Q
S
I
V
I
H
H
A
I
L
L
A
E
P
S
H
L
S
L
L
V
D
A
V
A
E
34
PsiBlast_CBE
67.48
36%
-97
- C1 -
4K2I
12
NTDA_BACSU
B:
[90-419]
---------------------
L
T
E
V
L
P
T
G
K
-----
F
T
--
S
G
P
Y
L
E
Q
--
F
E
K
V
L
S
T
Y
L
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
A
L
G
L
N
P
G
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
E
E
A
I
T
P
-------
Y
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
L
K
V
I
E
D
A
C
Q
G
I
G
L
T
D
L
G
K
----
Y
A
D
I
T
T
L
S
F
N
P
Y
K
N
F
G
V
C
G
K
A
G
A
I
A
T
D
N
E
E
L
A
K
K
----
C
I
Q
F
S
-------------
Y
H
G
----
F
-
E
VNV
K
--------------
N
K
K
V
I
N
F
---
G
F
N
S
K
M
D
N
L
Q
A
A
I
---
G
L
E
R
M
K
Y
L
S
L
N
N
F
K
R
L
F
L
A
D
R
Y
-----
I
T
Q
L
A
E
-
L
Q
N
K
GY
I
E
L
P
E
L
-
S
E
D
-----
H
V
W
H
L
----
F
P
I
K
V
R
---
T
-----
E
------
D
R
A
D
I
M
T
K
L
N
E
D
F
-
G
V
Q
T
D
V
---
Y
Y
P
I
LS
H
M
Q
K
T
------
P
L
V
Q
D
---
K
-----------------
Y
---
A
G
L
Q
L
V
H
T
E
K
A
H
S
Q
V
L
H
L
P
L
Y
P
-----------------
36
PsiBlast_CBE
65.60
31%
-91
- C1 -
4LC3
10
?
A:
[24-382]
-------------
I
D
E
E
T
I
Q
G
V
V
E
V
L
R
S
G
W
-----
I
T
--
T
G
P
Q
C
Q
K
--
F
E
A
A
L
S
E
Y
C
G
G
R
P
V
R
V
F
N
S
G
T
C
T
L
E
I
G
L
R
I
A
G
V
G
P
G
D
E
V
I
T
T
P
A
S
W
V
S
T
S
N
V
I
I
E
T
G
A
T
P
V
F
A
D
I
D
P
V
T
R
N
I
D
L
D
K
L
E
Q
A
I
T
P
-------
R
T
K
A
I
I
P
V
F
L
S
G
L
P
V
D
M
D
R
L
Y
A
I
A
R
A
H
K
L
R
V
I
E
D
A
A
Q
A
F
G
S
T
W
H
G
K
R
I
G
A
I
G
D
L
V
S
F
S
F
H
A
N
K
N
L
T
T
I
E
G
G
A
L
V
L
N
N
E
D
E
A
V
L
A
Q
K
Y
R
L
Q
G
I
T
-------------
R
T
G
----
F
-
D
---
G
--------------
M
D
C
D
V
-
L
---
G
G
K
Y
N
L
T
D
V
A
A
R
V
---
G
L
G
Q
L
P
H
L
E
R
F
T
A
Q
R
R
A
L
A
R
A
Y
F
A
A
F
D
G
G
A
A
A
K
-
L
G
----
V
G
L
P
V
A
-
E
F
E
-----
N
G
N
-
W
----
H
M
F
L
V
T
---
L
-----
P
LERLTI
T
R
A
E
F
M
A
Q
M
K
E
-
R
-
G
I
G
T
G
I
---
H
Y
P
A
IH
L
F
T
L
Y
------
R
A
R
G
F
---
K
-----------------
E
---
G
M
F
P
H
--
A
E
R
Y
G
A
S
T
V
T
L
P
L
F
T
Q
M
T
-
E
G
D
V
R
R
V
V
D
A
V
--
35
PsiBlast_CBE
64.36
31%
-92
* C1 *
4LC3
10
?
B:
[24-382]
-------------
I
D
E
E
T
I
Q
G
V
V
E
V
L
R
S
G
W
-----
I
T
--
T
G
P
Q
C
Q
K
--
F
E
A
A
L
S
E
Y
C
G
G
R
P
V
R
V
F
N
S
G
T
C
T
L
E
I
G
L
R
I
A
G
V
G
P
G
D
E
V
I
T
T
P
A
S
W
V
S
T
S
N
V
I
I
E
T
G
A
T
P
V
F
A
D
I
D
P
V
T
R
N
I
D
L
D
K
L
E
Q
A
I
T
P
-------
R
T
K
A
I
I
P
V
F
L
S
G
L
P
V
D
M
D
R
L
Y
A
I
A
R
A
H
K
L
R
V
I
E
D
A
A
Q
A
F
G
S
T
W
H
G
K
R
I
G
A
I
G
D
L
V
S
F
S
F
H
A
N
K
N
L
T
T
I
E
G
G
A
L
V
L
N
N
E
D
E
A
V
L
A
QKYR
L
Q
G
I
T
-------------
R
T
G
----
F
-
D
---
G
--------------
M
D
C
D
V
-
L
---
G
G
K
Y
N
L
T
D
V
A
A
R
V
---
G
L
G
Q
L
P
H
L
E
R
F
T
A
Q
R
R
A
L
A
R
A
Y
FAAFD
G
G
A
A
A
K
-
L
G
----
V
G
L
P
V
A
-
E
F
E
-----
N
G
N
-
W
----
H
M
F
L
V
T
---
L
-----
P
LERLTI
T
R
A
E
F
M
A
Q
M
K
E
-
R
-
G
I
G
T
G
I
---
H
Y
P
A
IH
L
F
T
L
Y
------
R
A
R
G
F
---
K
-----------------
E
---
G
M
F
P
H
--
A
E
R
Y
G
A
S
T
V
T
L
P
L
F
T
Q
M
T
-
E
G
D
V
R
R
V
V
D
A
V
--
37
PsiBlast_CBE
62.60
36%
-116
- C1 -
2C81
1
GLDSA_BACCI
A:
[36-286]
-----------------------------------
Y
W
--
T
G
E
E
S
M
E
R
K
F
A
K
A
F
A
D
F
N
G
V
P
Y
C
V
P
T
T
S
G
S
T
A
L
M
L
A
L
E
A
L
G
I
G
E
G
D
E
V
I
V
P
S
L
T
W
I
A
T
A
T
A
V
L
N
V
N
A
L
P
V
F
V
D
V
E
A
D
T
Y
C
I
D
P
Q
L
I
K
S
A
I
T
D
-------
K
T
K
A
I
I
P
V
H
L
F
G
S
M
A
N
M
D
E
I
N
E
I
A
Q
E
H
N
L
F
V
I
E
D
C
A
Q
S
H
G
S
V
W
N
N
Q
R
A
G
T
I
G
D
I
G
A
F
S
C
Q
Q
G
K
V
L
T
A
-
G
E
G
G
I
I
V
T
K
N
P
R
L
F
E
L
----
I
Q
Q
L
R
A
D
SRVYCDDSSEL
M
H
G
----
D
-
M
---
Q
--------------
L
V
K
K
G
D
I
Q
--
G
S
N
Y
C
L
S
E
F
Q
S
A
I
---
L
L
D
Q
L
Q
E
L
D
D
K
N
A
I
R
E
K
N
A
M
F
L
-----
N
D
A
L
S
K
-
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
62.45
36%
-115
- C1 -
2C7T
2
GLDSA_BACCI
A:
[36-286]
-----------------------------------
Y
W
--
T
G
E
E
S
M
E
R
K
F
A
K
A
F
A
D
F
N
G
V
P
Y
C
V
P
T
T
S
G
S
T
A
L
M
L
A
L
E
A
L
G
I
G
E
G
D
E
V
I
V
P
S
L
T
W
I
A
T
A
T
A
V
L
N
V
N
A
L
P
V
F
V
D
V
E
A
D
T
Y
C
I
D
P
Q
L
I
K
S
A
I
T
D
-------
K
T
K
A
I
I
P
V
H
L
F
G
S
M
A
N
M
D
E
I
N
E
I
A
Q
E
H
N
L
F
V
I
E
D
C
A
Q
S
H
G
S
V
W
N
N
Q
R
A
G
T
I
G
D
I
G
A
F
S
C
Q
Q
G
K
V
L
T
A
-
G
E
G
G
I
I
V
T
K
N
P
R
L
F
E
L
----
I
Q
Q
L
R
A
D
SRVYCDDSSEL
M
H
G
----
D
-
M
---
Q
--------------
L
V
K
K
G
D
I
Q
--
G
S
N
Y
C
L
S
E
F
Q
S
A
I
---
L
L
D
Q
L
Q
E
L
D
D
K
N
A
I
R
E
K
N
A
M
F
L
-----
N
D
A
L
S
K
-
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------