@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3187: (2016-02-14 )
MATLELRNLHKSYGSGLADTLRDIRLKIDSGEFLILVGPSGCGKSTLMNCIAGLESITGGAILVDGQDISGMSPKDRDIAMVFQSYALYPTMSVRENIAFGLKIRKMPQAAIDEEVARVARLLQIEHLLERKPSQLSGGQQQRVAMGRALARRPKVYLFDEPLSNLDAKLRVEMRTELKLMHQRLKTTTVYVTHDQIEAMTLGDKVAVMKDGVIQQFGTPQQIYNDPANLFVASFIGSPPMNFIPLRLQRRDGRWTGLLDSGQDRIELPLSLEPGLEEGRELILGVRPEQIALGDGSAAHDLRTEVEVLEPTGPDTLVFVTVNQVKVCCRLAPDVAPAAGSGMSLRFDPARVLLFDAQSGERVAVRTAGVAAEKVTALNGNRQKNS
Atome Classification :
(46 SA)
.........10..--......20........30........40........50........60.....---...----70---.------.---------------....-----..-.---------------80........90.......------.100....-....110.......120.......-130---.---.......140.......150.......160.......170.......180....--...190.......200.......210.......220.......230.......240.......250-........260.......270.---.....----.280.......290.-.--....----.300-----....-----.....310.......320.--...--...330.....-..340.......350.......360.......370.......380....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
T
L
E
L
R
N
L
H
K
S
Y--GS
G
L
A
D
T
L
R
D
I
R
L
K
IDSG
E
F
L
I
L
VGPSGC
G
K
S
T
L
M
N
C
I
A
G
L
E
S
ITG
G
A
I
L
VDG---QDI----S----G------M---------------SPK
D
-----
R
D
-
I
---------------
A
M
V
F
Q
S
YALYP
T
M
S
V
R
EN
I
------
A
F
G
-
L
K
I
R-KM
P
Q
A
A
I
D
E
E
V
A
R
V
A
R
L
L
Q
I
E
H
L
L
-
E
R----K---PSQLSGG
Q
Q
Q
R
V
A
M
G
R
A
L
ARR
P
K
V
Y
L
FDEPLSNLD
A
K
L
R
V
E
M
R
T
E
L
K
L
M
H
Q
RLK--
T
T
T
V
Y
V
THDQ
I
E
A
M
TLG
D
K
V
A
V
M
KD
G
V
I
Q
QFG
T
P
Q
Q
I
YND
P
A
N
L
F
V
A
S
FIGSPPM
N
F
I
P
L
R
L
QRR--DG
R
W
TGLLDSGQ
D
R
I
E
L
PLSLE---P
G
L
E
E----
G
R
E
L
I
L
GV
R
P
E
Q
I
AL-G--DGSA----AH-------DLRT-----
E
V
E
V
LEPTGP
D
T
L
V
F
V
T
V
N
--
Q
V
K
--
V
C
C
RLAPDVAP-AAGSG
M
S
L
R
FDP
A
R
V
L
L
F
DAQSG
E
R
V
A
V
R
TAGV
A
A
E
K
V
T
ALNGNRQKNS
1
PsiBlast_PDB
97.91
48%
-119
- C2 -
4TQU
-
?
S:
[2-358]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
--
D
K
--
T
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
---
R
V
I
----
N
----
D
------
L
---------------
A
P
K
D
-----
R
D
-
V
---------------
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
------
S
F
G
-
L
R
L
K
-
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
L
L
-
E
R
----
K
---
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
--
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
I
A
V
D
--
S
T
Q
H
V
E
L
--
N
G
G
N
R
I
S
L
L
P
R
A
G
---
T
H
L
A
P
----
G
Q
E
V
V
F
G
I
R
P
E
D
V
T
L
-
D
GV
E
G
S
E
----
R
A
-------
Q
I
K
A
-----
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
--
D
H
S
--
L
V
V
K
V
G
G
L
N
E
V
-
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
---------------------------
2
PsiBlast_PDB
97.27
48%
-119
- C2 -
4TQV
-
?
C:
[2-358]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
--
D
K
--
T
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
---
R
V
I
----
N
----
D
------
L
---------------
A
P
K
D
-----
R
D
-
V
---------------
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
------
S
F
G
-
L
R
L
K
-
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
L
L
-
E
R
----
K
---
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
--
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
I
A
V
D
--
S
T
Q
H
V
E
L
--
N
G
G
N
R
I
S
L
L
P
R
A
G
---
T
H
L
A
P
----
G
Q
E
V
V
F
G
I
R
P
E
D
V
T
L
-
D
GV
E
G
S
E
----
R
A
-------
Q
I
K
A
-----
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
--
D
H
S
--
L
V
V
K
V
G
G
L
N
E
V
-
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
---------------------------
17
PsiBlast_PDB
93.19
43%
-121
- C2 -
3PUX
5
MALK_ECOLI
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
----
D
------
T
---------------
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
------
S
F
G
-
L
K
L
A
-
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
----
K
---
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
--
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
AI
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
-
S
---
R
D
V
Q
V
----
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
-
S
--
D
-
I
A
----
D
V
-------
I
L
E
G
-----
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
--
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
-------------------------------
15
PsiBlast_PDB
92.45
43%
-120
- C2 -
3PUV
5
MALK_ECOLI
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
----
D
------
T
---------------
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
------
S
F
G
-
L
K
L
A
-
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
----
K
---
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
--
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
AI
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
-
S
---
R
D
V
Q
V
----
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
-
S
--
D
-
I
A
----
D
V
-------
I
L
E
G
-----
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
--
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
-------------------------------
5
PsiBlast_PDB
92.42
43%
-118
- C2 -
2D62
8
?
A:
[5-366]
-
A
E
V
K
L
I
N
I
W
K
R
F
--
G
D
V
T
A
--
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
E
D
---
N
L
V
----
A
----
D
PEKG
V
F
V
---------------
P
P
K
E
-----
R
D
-
V
---------------
A
M
V
F
Q
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
I
------
A
F
P
-
L
K
L
R
-
K
V
P
K
Q
E
I
D
K
R
V
R
E
V
A
E
M
L
G
L
T
E
L
L
-
N
R
----
K
---
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
G
--
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
G
S
P
P
M
N
F
L
D
A
T
I
T
D
-------
D
G
F
L
D
F
G
E
F
K
L
K
L
L
Q
D
Q
F
---
E
V
L
E
E
E
NMV
G
K
E
V
I
F
G
I
R
P
E
D
V
H
-----
D
A
S
F
----
T
H
IDVPEEN
T
V
K
A
-----
T
V
D
I
I
E
N
L
G
G
E
K
I
V
H
L
R
R
G
--
N
I
S
--
F
T
A
K
F
P
K
E
S
K
V
-
R
E
G
D
E
V
S
V
V
F
D
M
K
K
I
H
I
F
-------------------------------
22
PsiBlast_CBE
91.59
43%
-115
- C2 -
4KI0
4
?
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
----
D
------
T
---------------
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
------
S
F
G
-
L
K
L
A
-
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
----
K
---
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
--
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
AI
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
-
S
---
R
D
V
Q
V
----
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
-
S
--
D
-
I
A
----
D
V
-------
I
L
E
G
-----
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
--
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
-------------------------------
18
PsiBlast_PDB
91.42
43%
-118
- C2 -
3RLF
3
MALK_ECOLI
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
----
D
------
T
---------------
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
------
S
F
G
-
L
K
L
A
-
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
----
K
---
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
--
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
AI
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
-
S
---
R
D
V
Q
V
----
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
-
S
--
D
-
I
A
----
D
V
-------
I
L
E
G
-----
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
--
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
-------------------------------
16
PsiBlast_PDB
91.35
43%
-119
- C2 -
3PUW
5
MALK_ECOLI
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
----
D
------
T
---------------
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
------
S
F
G
-
L
K
L
A
-
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
----
K
---
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
--
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
AI
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
-
S
---
R
D
V
Q
V
----
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
-
S
--
D
-
I
A
----
D
V
-------
I
L
E
G
-----
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
--
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
-------------------------------
12
PsiBlast_PDB
91.29
43%
-118
- C2 -
3PUY
3
MALK_ECOLI
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
----
D
------
T
---------------
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
------
S
F
G
-
L
K
L
A
-
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
----
K
---
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
--
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
AI
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
-
S
---
R
D
V
Q
V
----
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
-
S
--
D
-
I
A
----
D
V
-------
I
L
E
G
-----
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
--
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
-------------------------------
34
PsiBlast_CBE
91.16
43%
-114
- C2 -
2R6G
2
MALK_ECOLI (first)
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
----
D
------
T
---------------
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
------
S
F
G
-
L
K
L
A
-
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
----
K
---
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
--
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
AI
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
-
S
---
R
D
V
Q
V
----
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
-
S
--
D
-
I
A
----
D
V
-------
I
L
E
G
-----
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
--
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
-------------------------------
4
PsiBlast_PDB
90.59
45%
-122
- C2 -
1VCI
1
?
A:
[10-368]
M
V
E
V
K
L
E
N
L
T
K
R
F
--
G
N
F
T
A
--
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
---
R
D
V
----
T
----
Y
------
L
---------------
P
P
K
D
-----
R
N
-
I
---------------
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
------
A
F
P
-
L
--
K
-
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
-
N
R
----
Y
---
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
--
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
E
V
S
V
G
--------
D
G
Y
L
E
G
R
G
F
R
I
E
L
P
Q
--
M
---
D
L
L
K
D
YV--
G
K
T
V
L
F
G
I
R
P
E
H
M
T
V
E
G
--
V
--------
H
-------
M
K
R
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
--
D
E
L
--
V
K
V
K
L
P
G
H
I
P
I
-
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
---------------------------
23
PsiBlast_CBE
90.47
43%
-118
- C2 -
3RLF
3
MALK_ECOLI
B:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
----
D
------
T
---------------
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
------
S
F
G
-
L
K
L
A
-
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
----
K
---
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
--
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
AI
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
-
S
---
R
D
V
Q
V
----
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
-
S
--
D
-
I
A
----
D
V
-------
I
L
E
G
-----
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
--
S
I
R
QN
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
-------------------------------
3
PsiBlast_PDB
90.42
45%
-122
- C2 -
1V43
-
?
A:
[10-368]
M
V
E
V
K
L
E
N
L
T
K
R
F
--
G
N
F
T
A
--
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
---
R
D
V
----
T
----
Y
------
L
---------------
P
P
K
D
-----
R
N
-
I
---------------
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
------
A
F
P
-
L
--
K
-
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
-
N
R
----
Y
---
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
--
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
E
V
S
V
G
--------
D
G
Y
L
E
G
R
G
F
R
I
E
L
P
Q
--
M
---
D
L
L
K
D
YV--
G
K
T
V
L
F
G
I
R
P
E
H
M
T
V
E
G
--
V
--------
H
-------
M
K
R
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
--
D
E
L
--
V
K
V
K
L
P
G
H
I
P
I
-
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
---------------------------
13
PsiBlast_PDB
89.90
43%
-116
- C2 -
3PUZ
2
MALK_ECOLI
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
----
D
------
T
---------------
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
------
S
F
G
-
L
K
L
A
-
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
----
K
---
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
--
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
AI
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
-
S
---
R
D
V
Q
V
----
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
-
S
--
D
-
I
A
----
D
V
-------
I
L
E
G
-----
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
--
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
-------------------------------
24
PsiBlast_CBE
89.79
43%
-117
- C2 -
3PUZ
2
MALK_ECOLI
B:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
----
D
------
T
---------------
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
------
S
F
G
-
L
K
L
A
-
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
----
K
---
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
--
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
AI
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
-
S
---
R
D
V
Q
V
----
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
-
S
--
D
-
I
A
----
D
V
-------
I
L
E
G
-----
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
--
S
I
R
QN
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
-------------------------------
111
HHSearch
89.76
46%
-118
- C2 -
1V43
-
?
A:
[10-372]
M
V
E
V
K
L
E
N
L
T
K
R
F
--
G
N
F
--
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
---
R
D
V
----
T
----
Y
------
L
---------------
P
P
K
D
-----
R
N
-
I
---------------
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
------
A
F
P
-
L
--
K
-
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
-
N
R
----
Y
---
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
--
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
E
V
S
V
G
D
G
--
Y
L
E
G
-----
R
G
F
-
R
I
--
E
L
P
Q
-MDL
L
K
D
Y
V
----
G
K
T
V
L
F
G
I
R
P
E
H
M
T
V
-
E
--
G
V
--HMK
R
T
A
-------
R
L
I
G
-----
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
E
L
V
K
--
V
K
L
P
---
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
K
A
I
-----------------------
19
PsiBlast_PDB
89.71
43%
-115
- C2 -
4JBW
-
MALK_ECOLI
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
----
D
------
T
---------------
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
------
S
F
G
-
L
K
L
A
-
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
----
K
---
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
--
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
AI
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
-
S
---
R
D
V
Q
V
----
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
-
S
--
D
-
I
A
----
D
V
-------
I
L
E
G
-----
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
--
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
-------------------------------
21
PsiBlast_CBE
89.60
43%
-117
- C2 -
4KI0
3
?
B:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
----
D
------
T
---------------
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
------
S
F
G
-
L
K
L
A
-
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
----
K
---
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
--
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
AI
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
-
S
---
R
D
V
Q
V
----
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
-
S
--
D
-
I
A
----
D
V
-------
I
L
E
G
-----
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
--
S
I
R
QN
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
-------------------------------
8
PsiBlast_PDB
89.60
43%
-115
- C2 -
1Q1E
-
MALK_ECOLI
A:
[4-355]
---
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
----
D
------
T
---------------
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
------
S
F
G
-
L
K
L
A
-
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
----
K
---
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
--
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
AI
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
-
S
---
R
D
V
Q
V
----
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
-
S
--
D
-
I
A
----
D
V
-------
I
L
E
G
-----
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
--
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
-------------------------------
7
PsiBlast_PDB
89.30
43%
-117
- C2 -
1Q12
2
MALK_ECOLI
A:
[4-355]
---
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
----
D
------
T
---------------
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
------
S
F
G
-
L
K
L
A
-
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
----
K
---
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
--
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
AI
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
-
S
---
R
D
V
Q
V
----
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
-
S
--
D
-
I
A
----
D
V
-------
I
L
E
G
-----
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
--
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
-------------------------------
62
PsiBlast_CBE
69.32
36%
-102
- C2 -
3FVQ
3
FBPC_NEIG1
B:
[3-290]
-
A
A
L
H
I
G
H
L
S
K
S
F
--
Q
N
--
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
---
K
T
I
FSKN
T
----
N
------
L
---------------
P
V
R
E
-----
R
R
-
L
---------------
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
------
A
Y
G
-
L
G
N
G
-
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
-
G
R
----
Y
---
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
--
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
G
I
V
--
F
P
A
A
L
N
-------
A
D
G
T
A
D
C
R
L
G
R
----
L
P
V
Q
---
S
G
A
P
A
----
G
T
R
G
T
L
L
I
R
P
E
Q
Y
S
L
-
H
--
P
H
S
A
-------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
68.46
36%
-104
- C2 -
3FVQ
3
FBPC_NEIG1
A:
[3-295]
-
A
A
L
H
I
G
H
L
S
K
S
F
--
Q
N
--
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
---
K
T
I
FSKN
T
----
N
------
L
---------------
P
V
R
E
-----
R
R
-
L
---------------
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
------
A
Y
G
-
L
G
N
G
-
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
-
G
R
----
Y
---
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
--
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
G
I
V
--
F
P
A
A
L
N
-------
A
D
G
T
A
D
C
R
L
G
R
----
L
P
V
Q
---
S
G
A
P
A
----
G
T
R
G
T
L
L
I
R
P
E
Q
Y
S
L
-
H
--
P
H
S
A
-------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
58.82
37%
-101
- C2 -
4U00
3
?
A:
[5-238]
---
I
R
I
R
N
L
H
K
W
F
--
G
P
--
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
LSV
K
D
D
----
R
----
A
------
L
---------------
R
E
I
R
-----
R
E
-
V
---------------
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
------
T
L
A
P
M
R
V
R
-
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
K
----
Y
---
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
57.37
33%
-102
- C2 -
3C4J
4
?
B:
[22-259]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
KAKD
T
----
N
------
L
---------------
N
K
V
R
-----
E
E
-
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
------
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
----
Y
---
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
57.20
35%
-102
- C2 -
1L2T
4
Y796_METJA
A:
[2-225]
---
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
---
I
K
T
----
N
----
D
------
L
---------------
D
D
D
E
L
T
K
I
R
R
D
K
I
---------------
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
------
E
L
P
-
L
I
F
K
-
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
FANH
K
---
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
--
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
57.19
34%
-99
* C2 *
2OLJ
4
?
A:
[22-259]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
--
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
----
K
----
A
KDTN--
L
---------------
N
K
V
R
-----
E
E
-
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
------
T
L
A
-
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
----
Y
---
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
56.67
34%
-97
- C2 -
1B0U
4
HISP_SALTY
A:
[5-253]
-
N
K
L
H
V
I
D
L
H
K
R
Y
--
G
G
H
--
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
---
Q
N
I
----
N
----
L
------
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
L
R
-----
T
R
-
L
---------------
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
------
M
E
A
-
P
I
Q
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
G
K
----
Y
---
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
G
--
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
56.41
33%
-95
- C2 -
2OLK
1
?
C:
[22-259]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
KAKD
T
----
N
------
L
---------------
N
K
V
R
-----
E
E
-
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
------
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
----
Y
---
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
56.31
38%
-84
- C2 -
4YMV
1
?
A:
[4-229]
-----
V
N
D
V
Y
K
N
F
--
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
----
N
NGKV
N
------
I
---------------
N
K
V
R
-----
Q
K
-
V
---------------
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
------
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
-
A
E
E
L
A
--
V
D
L
L
A
K
V
G
L
L
-
D
K
----
K
DQY
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
56.21
35%
-98
- C2 -
3TIF
7
Y796_METJA
A:
[2-225]
---
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
---
I
K
T
----
N
----
D
------
L
---------------
D
D
D
E
L
T
K
I
R
R
D
K
I
---------------
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
------
E
L
P
-
L
I
F
K
-
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
FANH
K
---
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
--
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
56.03
35%
-99
- C2 -
1L2T
4
Y796_METJA
B:
[2-225]
---
I
K
L
K
N
V
T
K
T
Y
KM
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
---
I
K
T
----
N
----
D
------
L
---------------
D
D
D
E
LTKIR
R
D
K
I
---------------
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
------
E
L
P
-
L
I
F
K
-
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
FANH
K
---
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
--
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
56.02
33%
-101
- C2 -
3C41
3
?
K:
[1-238]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
KAKD
T
----
N
------
L
---------------
N
K
V
R
-----
E
E
-
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
------
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
----
Y
---
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
56.02
33%
-97
- C2 -
2OLK
1
?
A:
[22-259]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
KAK
D
T
----
N
------
L
---------------
N
K
V
R
-----
E
E
-
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
------
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
----
Y
---
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
55.99
35%
-103
- C2 -
3TIF
7
Y796_METJA
B:
[2-225]
---
V
K
L
K
N
V
T
K
T
Y
KM
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
---
I
K
T
----
N
----
D
------
L
---------------
D
D
D
E
LTKIR
R
D
K
I
---------------
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
------
E
L
P
-
L
I
F
K
-
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
FANH
K
---
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
--
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
55.96
38%
-87
- C2 -
4YMU
2
?
J:
[4-229]
-----
V
N
D
V
Y
K
N
F
--
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
----
N
NGKV
N
------
I
---------------
N
K
V
R
-----
Q
K
-
V
---------------
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
------
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
-
A
E
E
L
A
--
V
D
L
L
A
K
V
G
L
L
-
D
K
----
K
DQY
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
55.73
33%
-97
- C2 -
2OLJ
4
?
A:
[22-259]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
KAKD
T
----
N
------
L
---------------
N
K
V
R
-----
E
E
-
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
------
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
----
Y
---
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
55.48
33%
-92
- C2 -
2OLK
1
?
D:
[22-259]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
KAKD
T
----
N
------
L
---------------
N
K
V
R
-----
E
E
-
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
------
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
----
Y
---
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
55.37
33%
-97
- C2 -
3C41
3
?
J:
[1-238]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
KAKD
T
----
N
------
L
---------------
N
K
V
R
-----
E
E
-
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
------
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
----
Y
---
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
55.36
38%
-88
- C2 -
4YMU
2
?
A:
[4-229]
-----
V
N
D
V
Y
K
N
F
--
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
----
N
NGKV
N
------
I
---------------
N
K
V
R
-----
Q
K
-
V
---------------
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
------
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
-
A
E
E
L
A
--
V
D
L
L
A
K
V
G
L
L
-
D
K
----
K
DQY
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
55.29
33%
-96
- C2 -
2Q0H
4
?
B:
[22-259]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
KAKD
T
----
N
------
L
---------------
N
K
V
R
-----
E
E
-
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
------
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
----
Y
---
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
55.26
33%
-94
- C2 -
2OLK
2
?
B:
[22-259]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
KAKD
T
----
N
------
L
---------------
N
K
V
R
-----
E
E
-
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
------
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
----
Y
---
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
54.75
38%
-85
- C2 -
4YMV
1
?
J:
[4-229]
-----
V
N
D
V
Y
K
N
F
--
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
----
N
NGKV
N
------
I
---------------
N
K
V
R
-----
Q
K
-
V
---------------
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
------
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
-
A
E
E
L
A
--
V
D
L
L
A
K
V
G
L
L
-
D
K
----
K
DQY
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
54.64
33%
-96
- C2 -
3C4J
3
?
A:
[22-259]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
KAKD
T
----
N
------
L
---------------
N
K
V
R
-----
E
E
-
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
------
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
----
Y
---
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
54.63
33%
-96
- C2 -
2Q0H
4
?
A:
[23-259]
-
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
KAKD
T
----
N
------
L
---------------
N
K
V
R
-----
E
E
-
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
------
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
----
Y
---
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
52.98
33%
-90
- C2 -
2OLJ
3
?
B:
[22-259]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
KAKD
T
----
N
------
L
---------------
N
K
V
R
-----
E
E
-
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
------
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
----
Y
---
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
52.55
33%
-102
- C2 -
1B0U
4
HISP_SALTY
A:
[7-253]
---
L
H
V
I
D
L
H
K
R
Y
--
G
G
--
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
---
Q
N
I
----
N
----
L
------
V
---------------
R
D
K
D
-----
G
Q
-
L
KVAD
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
EAPIQ
V
L
G
-
L
S
-----
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
-
G
K
----
Y
---
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
---
L
R
I
M
Q
Q
L
A
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------