@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3228: (2016-02-15 )
MLYRRFERLIDPFRSASERMPPSEVLRFYVYFLRQVWPVFLALLVVGLIVALIEVALFSYLGRIVDLAQSTPSAEFFRVHANELIWMAVVALVLRPLFNALHDMLVHQSINPSMTNLIRWQNHRYVLKQSLGFFQNDFAGRIAQRIMQTGNSLRDSAVQVVDALWHVLIYTVSALVLFAEADWRLMIPLVLWVFAYVGALAYFVPQVKRRSVEASDSRSKLMGRIVDGYTNITTLKLFAHTRQEEDYAREAIGDQTLKSQRAGRVVTSMDVTITVMNGVLITGTTGLALWLWSQELISVGAIALATGLVIRINNMSGWIMWVVGGIFENIGQVQDGMQTIALPRKVVDREDAQPLRVERGEVEFEHIAFHYGKGSGVIQGLDLKVRPGEKIGLVGPSGAGKSTLVNLLLRLYDLESGRILVDGQDIAGVTQESLRAQIGMVTQDTSLLHRSIRDNLLYGRPGASDAELMEAVRKARADEFIPLLSDAEGRRGFDAHVGERGVKLSGGQRQRIAIARVLLKDAPILILDEATSALDSEVESAIQESLETLMQGKTVIAIAHRLSTIARMDRLVVLDKGHIAESGTHAELLAHGGLYARLWQHQTGGFVGVD
Atome Classification :
(66 SA)
.........10........20........30........40........50.....-------...60..-......70........80...---.....90---........100.......110.......120.......130.......140.......150.......160.......170....--...180...------....190........200.......210.......220.......230.......240...-----....250--.......260.......270----.........280--.......290.......300.....----..310.......320.....--..330...-----------....340......--.350-.------.----.......--360.......370..--.--..-.--.--.380.......390.......400.......410...---....420......--.430........440......-.450.......---460---.-......470.-......480.......490........500.......510.......520.......530....----...540.......550.----........560.....--.--.570.......580.......590-.--.......600.......610
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
Y
R
R
F
E
R
L
I
D
P
F
R
S
A
S
ERM
P
P
S
E
V
L
R
F
Y
V
Y
F
L
R
Q
V
W
P
V
F
L
A
L
L
V
V
G
L
I
V
A
L
I
E
V
A
-------
L
F
S
Y
L
G
R
-
I
V
D
L
A
QSTPSA
E
F
F
R
V
H
A
N
E
L
---
I
W
M
A
V
V
A
---
L
V
L
R
P
L
F
N
A
L
H
D
M
L
V
HQSI
N
P
S
M
T
N
L
I
R
WQN
H
R
Y
V
L
K
Q
S
L
G
F
FQN
D
F
A
G
R
I
A
Q
R
I
M
QTGNS
L
R
D
S
A
V
Q
V
V
D
A
L
W
H
V
L
I
Y
T
V
S
A
L
V
--
L
FAEAD
W
R
L
------
M
I
P
L
V
-
L
W
V
F
A
Y
V
G
A
L
A
Y
F
V
P
Q
V
K
R
RSVEASD
S
R
S
K
L
M
G
R
I
VDGYTN
I
T
T
L
K
L
F
AHTR
Q
E
E
-----
D
Y
A
R
E
AI--G
D
Q
T
L
K
S
QRAG
R
V
V
T
S
M
D
------
V
T
I
T
V
MN
G
V
L
I
T--GTT
G
L
A
L
W
L
W
S
Q
E
L
I
S
V
G
A
I
A
L
AT
G
----
L
V
I
R
I
NNMS
G
W
I
M
W
V
V
G
G
I
F
--
E
N
I
G
Q
V
Q
D
-----------
G
M
Q
T
IAL
P
R
K
VVD--RE---D------A----QP
L
R
VER--GE
V
E
F
E
H
I
A
F
H
Y-GK--G--SG-
V
--
I
--QG
L
D
L
K
VRPG
E
K
I
G
L
VGPSGA
G
K
S
T
L
V
N
L
L
L
R
L
YDLE---S
G
R
I
L
VDGQDI
A
G
--
V
T
Q
-
E
S
L
R
A
QIGMVT
Q
D
T
S
L
L
-
H
R
S
I
R
DNLLYG---RPG---A-
S
D
A
E
L
M
E
A
V
R
-
K
AR
A
D
E
F
I
PLLSDAEGR-RGF
D
A
HVGERGVKLSGGQ
R
Q
R
I
A
I
A
R
V
L
LKDA
P
I
L
I
LDE
A
T
S
A
L
D
S
----
E
V
E
S
A
I
Q
E
S
L
E
T
L
M--Q----G
K
T
V
I
A
I
A
H
R
L
S
T
I
A
R--M--
D
R
L
V
V
L
DKGHIAESG
T
H
A
E
L
L
AH--G--
G
L
Y
A
R
L
W
QHQTGGFVGVD
25
PsiBlast_CBE
84.87
31%
-108
- C3 -
3WMF
1
?
A:
[22-595]
------------------------------------
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
-
V
F
T
K
S
K
S
Q
I
E
G
E
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
---
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
---------
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
------
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
-
E
A
Y
A
S
A
G
S
V
A
A
E
V
---
F
S
N
I
R
T
T
K
A
F
----
E
A
E
-----
R
Y
E
T
Q
R
Y
--
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
------
G
L
F
F
G
L
S
M
L
V
I
F
--
C
V
Y
A
L
A
L
W
-
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
-----------
N
L
L
T
A
F
F
S
A
I
L
G
--
F
--
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
P
Q
YR
R
P
---
D
PGAEVV
T
----
Q
P
L
V
L
K
Q
--
G
I
V
-
F
E
N
V
H
F
R
Y
-
P
T
RM
N
--
V
E
-
V
--
L
--
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
--
Y
D
F
-
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
-
S
G
T
I
R
D
N
I
L
Y
G
---
K
R
D
---
A
-
T
D
E
E
V
I
Q
A
L
R
-
E
A
N
A
Y
S
F
V
M
A
L
P
D
------
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
----
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
----
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
--
A
--
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
--
G
PS
G
F
Y
Y
Q
L
V
E
K
Q
--------
24
PsiBlast_CBE
83.40
31%
-105
- C3 -
3WMG
6
?
A:
[22-595]
------------------------------------
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
-
V
F
T
K
S
K
S
Q
I
E
G
E
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
---
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
---------
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
------
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
-
E
A
Y
A
S
A
G
S
V
A
A
E
V
---
F
S
N
I
R
T
T
K
A
F
----
E
A
E
-----
R
Y
E
T
Q
R
Y
--
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
------
G
L
F
F
G
L
S
M
L
V
I
F
--
C
V
Y
A
L
A
L
W
-
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
-----------
N
L
L
T
A
F
F
S
A
I
L
G
--
F
--
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
P
Q
YR
R
P
---
D
PG
A
E
V
V
T
----
Q
P
L
V
L
K
Q
--
G
I
V
-
F
E
N
V
H
F
R
Y
-
P
T
RM
N
--
V
E
-
V
--
L
--
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
--
Y
D
F
-
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
-
S
G
T
I
R
D
N
I
L
Y
G
---
K
R
D
---
A
-
T
D
E
E
V
I
Q
A
L
R
-
E
A
N
A
Y
S
F
V
M
A
L
P
D
------
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
----
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
----
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
--
A
--
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
--
G
PS
G
F
Y
Y
Q
L
V
E
K
Q
--------
1
PsiBlast_PDB
78.89
31%
-97
- C3 -
2HYD
3
Y1866_STAAM
A:
[69-577]
----------------------------------------------------------------------------------------------------
I
F
---
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
-
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
--
I
M
F
F
L
D
V
K
L
------
T
L
A
A
L
-
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
--
D
K
K
N
T
N
F
--
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
------
N
T
V
T
D
I
G
P
I
I
V
I
--
G
---
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
----
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
--
Q
S
F
A
S
M
D
R
-----------
V
F
Q
L
I
D
E
D
Y
D
I
K
N
--
G
V
---
G
------
A
----
Q
P
I
E
I
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
--
N
--
E
A
P
I
--
L
--
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
--
F
L
T
-
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
L
G
---
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
-
M
A
N
A
H
D
F
I
M
N
L
P
------
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
----
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
----
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
--
A
--
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
--
G
A
Y
E
H
L
Y
S
I
Q
N
-------
22
PsiBlast_CBE
78.76
31%
-96
- C3 -
2HYD
3
Y1866_STAAM
B:
[69-577]
----------------------------------------------------------------------------------------------------
I
F
---
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
-
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
--
I
M
F
F
L
D
V
K
L
------
T
L
A
A
L
-
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
KNF--
D
K
K
N
T
N
F
--
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
------
N
T
V
T
D
I
G
P
I
I
V
I
--
G
---
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
----
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
--
Q
S
F
A
S
M
D
R
-----------
V
F
Q
L
I
D
E
D
Y
D
I
K
N
--
G
V
---
G
------
A
----
Q
P
I
E
I
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
--
N
--
E
A
P
I
--
L
--
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
--
F
L
T
-
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
L
G
---
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
-
M
A
N
A
H
D
F
I
M
N
L
P
------
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
----
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
----
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
--
A
--
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
--
G
A
Y
E
H
L
Y
S
I
Q
N
-------
21
PsiBlast_CBE
76.81
31%
-95
- C3 -
2ONJ
4
Y1866_STAAM
B:
[69-577]
----------------------------------------------------------------------------------------------------
I
F
---
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
-
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
--
I
M
F
F
L
D
V
K
L
------
T
L
A
A
L
-
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
KNF--
D
K
K
N
T
N
F
--
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
------
N
T
V
T
D
I
G
P
I
I
V
I
--
G
---
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
----
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
--
Q
S
F
A
S
M
D
R
-----------
V
F
Q
L
I
D
E
D
Y
D
I
K
N
--
G
V
---
G
------
A
----
Q
P
I
E
I
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
--
N
--
E
A
P
I
--
L
--
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
--
F
L
T
-
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
L
G
---
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
-
M
A
N
A
H
D
F
I
M
N
L
P
------
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
----
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
----
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
--
A
--
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
--
G
A
Y
E
H
L
Y
S
I
Q
N
-------
2
PsiBlast_PDB
76.75
31%
-95
- C3 -
2ONJ
4
Y1866_STAAM
A:
[69-577]
----------------------------------------------------------------------------------------------------
I
F
---
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
-
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
--
I
M
F
F
L
D
V
K
L
------
T
L
A
A
L
-
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
--
D
K
K
N
T
N
F
--
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
------
N
T
V
T
D
I
G
P
I
I
V
I
--
G
---
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
----
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
--
Q
S
F
A
S
M
D
R
-----------
V
F
Q
L
I
D
E
D
Y
D
I
K
N
--
G
V
---
G
------
A
----
Q
P
I
E
I
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
--
N
--
E
A
P
I
--
L
--
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
--
F
L
T
-
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
L
G
---
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
-
M
A
N
A
H
D
F
I
M
N
L
P
------
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
----
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
----
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
--
A
--
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
--
G
A
Y
E
H
L
Y
S
I
Q
N
-------
11
PsiBlast_PDB
73.01
33%
-100
- C3 -
4Q4H
-
Y288_THEMA
B:
[125-592]
------------------------------------------------------------------------------------------------------------------------------------------------
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
--
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
-
V
L
I
T
Q
I
V
S
S
------
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
--
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
--
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
------
N
M
V
N
N
L
G
F
A
L
I
S
--
G
F
G
G
---
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
RQ
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-----------
L
E
E
E
-------
K
D
--
D
P
---
D
------
A
----
V
E
L
R
E
V
R
--
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
--
K
--
K
P
-
V
--
L
--
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
--
I
K
R
-
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
Y
G
---
N
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
-
L
T
H
S
D
H
F
I
K
H
L
P
E
------
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
----
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
----
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
--
A
--
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
--
G
F
Y
Y
E
L
F
T
S
Q
Y
G
------
9
PsiBlast_PDB
72.30
33%
-105
- C3 -
3QF4
1
Y288_THEMA
B:
[125-592]
------------------------------------------------------------------------------------------------------------------------------------------------
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
--
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
-
V
L
I
T
Q
I
V
S
S
------
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
--
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
--
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
------
N
M
V
N
N
L
G
F
A
L
I
S
--
G
F
G
G
---
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
RQ
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-----------
L
E
E
E
-------
K
D
--
D
P
---
D
------
A
----
V
E
L
R
E
V
R
--
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
--
K
--
K
P
-
V
--
L
--
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
--
I
K
R
-
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
Y
G
---
N
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
-
L
T
H
S
D
H
F
I
K
H
L
P
E
------
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
----
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
----
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
--
A
--
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
--
G
F
Y
Y
E
L
F
T
S
Q
Y
G
------
104
HHSearch
72.12
27%
-103
- C3 -
3WMG
5
?
A:
[29-598]
---------------------------------------
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
-------
F
A
I
V
F
G
R
-
M
F
Q
V
F
T
K
S
K
S
Q
I
-
E
-
G
E
T
W
K
Y
---
S
V
G
F
V
G
I
---
G
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
-
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
L
-
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
--
V
A
F
I
F
A
P
A
L
------
T
G
V
L
I
-
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
-----
Q
R
Y
G
S
K
L
--
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
------
G
L
S
M
L
V
I
F
C
V
Y
A
--
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
----
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
--
R
G
L
G
A
G
G
E
-----------
L
F
A
M
I
D
R
V
P
Q
Y
R
R
--
P
D
---
P
------
G
A
E
V
V
T
Q
P
L
V
L
K
--
Q
G
I
V
F
E
N
V
H
F
R
Y
-
P
T
--
R
MN
V
E
-
V
--
L
--
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
--
Y
D
F
-
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
-
S
G
T
I
R
D
N
I
L
Y
G
---
K
R
D
---
A
-
T
D
E
E
V
I
Q
A
L
R
-
E
A
N
A
Y
S
F
V
M
A
L
P
------
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
----
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
----
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
--
A
--
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
GP
S
--
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
-----
103
HHSearch
72.00
27%
-106
- C3 -
3ZDQ
6
ABCBA_HUMAN
A:
[7-572]
-------------------------
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
-------
A
P
F
F
L
G
K
-
I
I
D
V
I
Y
T
N
P
T
V
D
Y
S
-
D
N
L
T
R
L
---
C
L
G
L
S
A
V
---
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
-
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
--
M
M
F
F
V
S
P
N
L
------
A
T
F
V
L
-
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
-----
E
K
Y
A
S
K
V
--
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
------
G
A
T
G
L
S
G
N
L
I
V
L
--
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
----
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
--
K
G
L
G
A
G
G
R
-----------
L
W
E
L
L
E
R
E
P
K
L
P
F
--
N
E
---
G
------
V
I
---
L
N
E
K
S
F
Q
--
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
--
R
PE
V
P
-
I
--
F
--
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
--
L
N
P
-
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
G
---
A
D
D
PSS
V
-
T
A
E
E
I
Q
R
V
A
E
-
V
A
N
A
V
A
F
I
R
N
F
P
------
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
----
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
----
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
--
A
--
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P----------------------
10
PsiBlast_PDB
71.99
33%
-103
- C3 -
4Q4A
1
Y288_THEMA
B:
[125-592]
------------------------------------------------------------------------------------------------------------------------------------------------
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
--
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
-
V
L
I
T
Q
I
V
S
S
------
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
--
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
--
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
------
N
M
V
N
N
L
G
F
A
L
I
S
--
G
F
G
G
---
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
RQ
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-----------
L
E
E
E
-------
K
D
--
D
P
---
D
------
A
----
V
E
L
R
E
V
R
--
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
--
K
--
K
P
-
V
--
L
--
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
--
I
K
R
-
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
Y
G
---
N
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
-
L
T
H
S
D
H
F
I
K
H
L
P
E
------
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
----
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
----
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
--
A
--
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
--
G
F
Y
Y
E
L
F
T
S
Q
Y
G
------
20
PsiBlast_PDB
71.94
30%
-99
- C3 -
3B60
2
MSBA_SALTY
A:
[13-581]
--------------------------------
F
R
R
L
W
P
T
-
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
-------
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
R
S
V
L
---
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
-
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
--
M
M
F
Y
Y
S
W
Q
L
------
S
I
I
L
V
---
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
--
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
----
L
K
G
H
-------------
K
E
V
L
IF
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
----
I
T
V
V
F
S
S
M
I
A
-
L
M
R
P
L
K
S
L
T
--
N
V
N
A
Q
F
Q
R
-----------
G
M
A
A
C
Q
T
L
F
A
I
L
D
--
S
E
QEK
D
------
E
----
G
K
R
V
I
D
R
AT
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
--
E
--
V
P
-
A
--
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
--
Y
T
L
-
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
---
R
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
-
M
A
Y
A
M
D
F
I
N
K
M
D
N
------
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
----
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
----
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
--
A
--
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
--
G
V
Y
A
Q
L
H
K
M
Q
F
G
------
12
PsiBlast_PDB
71.21
32%
-104
- C3 -
4Q4J
-
Y288_THEMA
B:
[125-592]
------------------------------------------------------------------------------------------------------------------------------------------------
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
--
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
-
V
L
I
T
Q
I
V
S
S
------
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
--
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
--
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
------
N
M
V
N
N
L
G
F
A
L
I
S
--
G
F
G
G
---
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
RQ
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-----------
L
E
E
E
-------
K
D
--
D
P
---
D
------
A
----
V
E
L
R
E
V
R
--
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
--
K
--
K
P
-
V
--
L
--
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
--
I
K
R
-
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
Y
G
---
N
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
-
L
T
H
S
D
H
F
I
K
H
L
P
E
------
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
----
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
----
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
--
A
--
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
--
G
F
Y
Y
E
L
F
T
S
Q
Y
G
------
101
HHSearch
66.32
26%
-104
* C3 *
3B60
2
MSBA_SALTY
A:
[10-581]
----------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
-------
M
L
S
L
L
K
P
-
L
L
D
D
G
F
G
K
T
D
R
S
V
L
----
L
W
M
---
P
L
V
V
I
G
L
---
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
-
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
--
M
M
F
Y
Y
S
W
Q
L
------
S
I
I
L
V
-
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
-----
K
R
F
D
K
V
S
--
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
------
P
I
I
Q
L
I
A
S
L
A
L
A
--
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
----
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
--
R
G
M
A
A
C
Q
T
-----------
L
F
A
I
L
D
S
E
Q
E
K
D
E
--
G
K
---------------
R
V
I
D
R
A
T
--
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
--
R
E-
V
P
-
A
--
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
--
Y
T
L
-
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
---
R
T
E
E--
Y
-
S
R
E
Q
I
E
E
A
A
R
-
M
A
Y
A
M
D
F
I
N
K
M
D
------
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
----
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
----
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
--
A
--
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
--
G
V
Y
A
Q
L
H
K
M
Q
F
G
------
7
PsiBlast_PDB
64.85
38%
-100
- C3 -
4MRS
9
ATM1_NOVAD
A:
[221-596]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
R
A
V
D
S
L
L
N
Y
E
T
V
K
Y
F
G
A
E
S
R
E
E
-----
A
R
Y
A
S
A
A
--
R
A
Y
A
D
A
A
V
K
S
E
N
S
L
G
L
L
N
------
I
A
Q
A
L
I
V
N
L
L
M
A
--
G
A
M
A
W
T
V
Y
G
W
S
Q
G
K
L
T
V
G
D
L
V
F
V
N
T
----
Y
L
T
Q
L
F
R
P
L
D
M
L
G
M
V
Y
R
T
I
R
--
Q
G
L
I
D
M
A
E
-----------
M
F
R
L
I
D
T
H
I
E
V
A
D
--
V
P
---
N
------
A
----
P
A
L
V
V
N
R
--
P
S
V
T
F
D
N
V
V
F
G
Y
-
D
R
--
D
--
R
E
-
I
--
L
--
H
G
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
D
P
W
---
E
G
R
I
L
I
D
G
Q
D
I
A
H
--
V
T
Q
-
T
S
L
R
A
A
L
G
I
V
P
Q
D
S
V
L
F
-
N
D
T
I
G
Y
N
I
A
Y
G
---
R
D
G
---
A
-
S
R
A
E
V
D
A
A
A
K
-
G
A
A
I
A
D
F
I
A
R
L
P
------
Q
G
Y
D
T
E
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
I
L
L
F
D
E
A
T
S
A
L
D
T
----
R
T
E
Q
D
I
L
S
T
M
R
A
V
A
--
S
----
H
R
T
T
I
S
I
A
H
R
L
S
T
I
A
D
--
S
--
D
T
I
L
V
L
D
Q
G
R
L
A
E
Q
G
S
H
L
D
L
L
R
R
--
D
--
G
L
Y
A
E
M
W
A
R
Q
--------
8
PsiBlast_PDB
64.74
38%
-101
- C3 -
4MRV
6
ATM1_NOVAD
A:
[221-596]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
R
A
V
D
S
L
L
N
Y
E
T
V
K
Y
F
G
A
E
S
R
E
E
-----
A
R
Y
A
S
A
A
--
R
A
Y
A
D
A
A
V
K
S
E
N
S
L
G
L
L
N
------
I
A
Q
A
L
I
V
N
L
L
M
A
--
G
A
M
A
W
T
V
Y
G
W
S
Q
G
K
L
T
V
G
D
L
V
F
V
N
T
----
Y
L
T
Q
L
F
R
P
L
D
M
L
G
M
V
Y
R
T
I
R
--
Q
G
L
I
D
M
A
E
-----------
M
F
R
L
I
D
T
H
I
E
V
A
D
--
V
P
---
N
------
A
----
P
A
L
V
V
N
R
--
P
S
V
T
F
D
N
V
V
F
G
Y
-
D
R
--
D
--
R
E
-
I
--
L
--
H
G
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
D
P
W
---
E
G
R
I
L
I
D
G
Q
D
I
A
H
--
V
T
Q
-
T
S
L
R
A
A
L
G
I
V
P
Q
D
S
V
L
F
-
N
D
T
I
G
Y
N
I
A
Y
G
---
R
D
G
---
A
-
S
R
A
E
V
D
A
A
A
K
-
G
A
A
I
A
D
F
I
A
R
L
P
------
Q
G
Y
D
T
E
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
I
L
L
F
D
E
A
T
S
A
L
D
T
----
R
T
E
Q
D
I
L
S
T
M
R
A
V
A
--
S
----
H
R
T
T
I
S
I
A
H
R
L
S
T
I
A
D
--
S
--
D
T
I
L
V
L
D
Q
G
R
L
A
E
Q
G
S
H
L
D
L
L
R
R
--
D
--
G
L
Y
A
E
M
W
A
R
Q
--------
4
PsiBlast_PDB
64.49
38%
-101
- C3 -
4MRN
6
ATM1_NOVAD
A:
[221-596]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
R
A
V
D
S
L
L
N
Y
E
T
V
K
Y
F
G
A
E
S
R
E
E
-----
A
R
Y
A
S
A
A
--
R
A
Y
A
D
A
A
V
K
S
E
N
S
L
G
L
L
N
------
I
A
Q
A
L
I
V
N
L
L
M
A
--
G
A
M
A
W
T
V
Y
G
W
S
Q
G
K
L
T
V
G
D
L
V
F
V
N
T
----
Y
L
T
Q
L
F
R
P
L
D
M
L
G
M
V
Y
R
T
I
R
--
Q
G
L
I
D
M
A
E
-----------
M
F
R
L
I
D
T
H
I
E
V
A
D
--
V
P
---
N
------
A
----
P
A
L
V
V
N
R
--
P
S
V
T
F
D
N
V
V
F
G
Y
-
D
R
--
D
--
R
E
-
I
--
L
--
H
G
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
D
P
W
---
E
G
R
I
L
I
D
G
Q
D
I
A
H
--
V
T
Q
-
T
S
L
R
A
A
L
G
I
V
P
Q
D
S
V
L
F
-
N
D
T
I
G
Y
N
I
A
Y
G
---
R
D
G
---
A
-
S
R
A
E
V
D
A
A
A
K
-
G
A
A
I
A
D
F
I
A
R
L
P
------
Q
G
Y
D
T
E
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
I
L
L
F
D
E
A
T
S
A
L
D
T
----
R
T
E
Q
D
I
L
S
T
M
R
A
V
A
--
S
----
H
R
T
T
I
S
I
A
H
R
L
S
T
I
A
D
--
S
--
D
T
I
L
V
L
D
Q
G
R
L
A
E
Q
G
S
H
L
D
L
L
R
R
--
D
--
G
L
Y
A
E
M
W
A
R
Q
--------
3
PsiBlast_PDB
64.43
31%
-94
- C3 -
4A82
-
Y1866_STAAM
A:
[69-577]
----------------------------------------------------------------------------------------------------
I
F
---
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
-
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
--
I
M
F
F
L
D
V
K
L
------
T
L
A
A
L
-
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
--
D
K
K
N
T
N
F
--
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
------
N
T
V
T
D
I
G
P
I
I
V
I
--
G
---
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
----
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
--
Q
S
F
A
S
M
D
R
-----------
V
F
Q
L
I
D
E
D
Y
D
I
K
N
--
G
V
---
G
------
A
----
Q
P
I
E
I
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
--
N
--
E
A
P
I
--
L
--
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
--
F
L
T
-
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
L
G
---
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
-
M
A
N
A
H
D
F
I
M
N
L
P
------
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
----
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
----
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
--
A
--
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
--
G
A
Y
E
H
L
Y
S
I
Q
N
-------
5
PsiBlast_PDB
64.28
38%
-99
- C3 -
4MRP
7
ATM1_NOVAD
A:
[221-596]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
R
A
V
D
S
L
L
N
Y
E
T
V
K
Y
F
G
A
E
S
R
E
E
-----
A
R
Y
A
S
A
A
--
R
A
Y
A
D
A
A
V
K
S
E
N
S
L
G
L
L
N
------
I
A
Q
A
L
I
V
N
L
L
M
A
--
G
A
M
A
W
T
V
Y
G
W
S
Q
G
K
L
T
V
G
D
L
V
F
V
N
T
----
Y
L
T
Q
L
F
R
P
L
D
M
L
G
M
V
Y
R
T
I
R
--
Q
G
L
I
D
M
A
E
-----------
M
F
R
L
I
D
T
H
I
E
V
A
D
--
V
P
---
N
------
A
----
P
A
L
V
V
N
R
--
P
S
V
T
F
D
N
V
V
F
G
Y
-
D
R
--
D
--
R
E
-
I
--
L
--
H
G
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
D
P
W
---
E
G
R
I
L
I
D
G
Q
D
I
A
H
--
V
T
Q
-
T
S
L
R
A
A
L
G
I
V
P
Q
D
S
V
L
F
-
N
D
T
I
G
Y
N
I
A
Y
G
---
R
D
G
---
A
-
S
R
A
E
V
D
A
A
A
K
-
G
A
A
I
A
D
F
I
A
R
L
P
------
Q
G
Y
D
T
E
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
I
L
L
F
D
E
A
T
S
A
L
D
T
----
R
T
E
Q
D
I
L
S
T
M
R
A
V
A
--
S
----
H
R
T
T
I
S
I
A
H
R
L
S
T
I
A
D
--
S
--
D
T
I
L
V
L
D
Q
G
R
L
A
E
Q
G
S
H
L
D
L
L
R
R
--
D
--
G
L
Y
A
E
M
W
A
R
Q
--------
122
Fugue
64.11
26%
-100
- C3 -
3B60
2
MSBA_SALTY
A:
[10-581]
----------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
-------
M
L
S
L
L
K
P
-
L
L
D
D
G
F
G
K
T
D
R
S
V
L
L
W
--------
M
P
L
V
V
I
G
---
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
--
M
M
F
Y
Y
S
W
Q
L
------
S
I
I
L
V
-
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
-----
K
R
F
D
K
V
S
--
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
------
P
I
I
Q
L
I
A
S
L
A
L
A
--
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
----
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
--
R
G
M
A
A
C
Q
T
-----------
L
F
A
I
L
D
S
E
Q
E
K
----
D
E
---
G
------
K
----
R
V
I
D
R
A
T
--
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
--
E
--
V
P
-
A
--
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
--
Y
T
L
-
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
---
R
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
-
M
A
Y
A
M
D
F
I
N
K
M
D
N
------
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
----
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
----
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
--
A
--
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
--
G
V
Y
A
Q
L
H
K
M
Q
F
G
------
14
PsiBlast_PDB
62.40
48%
-98
- C3 -
3NH9
3
A:
[37-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
K
D
--
L
P
---
G
------
A
----
G
P
L
R
F
Q
K
--
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
--
G
--
R
E
-
T
--
L
--
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
--
V
T
Q
-
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
-
N
D
T
I
A
D
N
I
R
Y
G
---
R
V
T
---
A
-
G
N
D
E
V
E
A
A
A
Q
-
A
A
G
I
H
D
A
I
M
A
F
P
E
------
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
----
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
----
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
--
A
--
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
--
G
V
Y
A
D
M
W
Q
L
Q
Q
G
------
49
PsiBlast_CBE
61.34
46%
-107
- C3 -
1XEF
3
HLYBP_ECOLX
B:
[1-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
42
PsiBlast_CBE
61.33
46%
-109
- C3 -
2FGJ
2
D:
[7-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
33
PsiBlast_CBE
61.00
46%
-108
- C3 -
2FGK
2
HLYBP_ECOLX
B:
[7-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
48
PsiBlast_CBE
60.96
46%
-110
- C3 -
1XEF
3
HLYBP_ECOLX
C:
[1-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
114
HHSearch
60.86
47%
-106
- C3 -
2FF7
1
A:
[5-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
--
H
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
S-
P
V
-
I
--
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
S
E
L
R
------
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
--
S
L
Y
S
Y
L
Y
Q
L
Q
--------
43
PsiBlast_CBE
60.83
46%
-106
- C3 -
2FGJ
2
HLYBP_ECOLX
C:
[7-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
50
PsiBlast_CBE
60.51
46%
-104
- C3 -
1XEF
3
HLYBP_ECOLX
A:
[1-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
15
PsiBlast_PDB
59.96
48%
-98
- C3 -
3NHA
4
A:
[37-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
K
D
--
L
P
---
G
------
A
----
G
P
L
R
F
Q
K
--
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
-----
R
E
-
T
--
L
--
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
--
V
T
Q
-
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
-
N
D
T
I
A
D
N
I
R
Y
G
---
R
V
T
---
A
-
G
N
D
E
V
E
A
A
A
Q
-
A
A
G
I
H
D
A
I
M
A
F
P
E
------
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
----
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
----
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
--
A
--
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
--
G
V
Y
A
D
M
W
Q
L
Q
Q
G
------
31
PsiBlast_CBE
59.93
46%
-108
- C3 -
2FGK
2
D:
[7-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
27
PsiBlast_CBE
59.88
47%
-104
- C3 -
2FF7
1
A:
[7-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
16
PsiBlast_PDB
59.73
48%
-100
- C3 -
3NHB
3
A:
[37-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
K
D
--
L
P
---
G
------
A
----
G
P
L
R
F
Q
K
--
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
-----
R
E
-
T
--
L
--
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
--
V
T
Q
-
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
-
N
D
T
I
A
D
N
I
R
Y
G
---
R
V
T
---
A
-
G
N
D
E
V
E
A
A
A
Q
-
A
A
G
I
H
D
A
I
M
A
F
P
E
------
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
----
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
----
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
--
A
--
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
--
G
V
Y
A
D
M
W
Q
L
Q
Q
G
------
32
PsiBlast_CBE
59.64
46%
-103
- C3 -
2FGK
2
HLYBP_ECOLX
C:
[7-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
30
PsiBlast_CBE
59.59
47%
-108
- C3 -
2PMK
1
A:
[3-242]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
47
PsiBlast_CBE
59.44
46%
-104
- C3 -
1XEF
3
D:
[1-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
34
PsiBlast_CBE
59.09
46%
-102
- C3 -
2FGK
2
HLYBP_ECOLX
A:
[7-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
44
PsiBlast_CBE
58.33
46%
-104
- C3 -
2FGJ
2
HLYBP_ECOLX
B:
[7-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
35
PsiBlast_CBE
58.26
46%
-103
- C3 -
2FFB
1
A:
[7-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
40
PsiBlast_CBE
58.21
46%
-103
- C3 -
3B5J
1
A:
[3-242]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
46
PsiBlast_CBE
58.10
46%
-102
- C3 -
2FFA
2
A:
[7-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
45
PsiBlast_CBE
57.83
46%
-101
- C3 -
2FGJ
2
HLYBP_ECOLX
A:
[7-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
--
D
--
S
P
-
V
--
I
L-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
-
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
---
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
-----
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
----
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
--
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E-
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
110
HHSearch
55.56
36%
-95
- C3 -
2IXE
4
TAP1_RAT
A:
[13-256]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
--
H
PN
V
Q
-
V
--
L
--
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
-
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
---
L
T
R
---
T
P
T
M
E
E
I
T
A
V
A
M
-
E
S
G
A
H
D
F
I
S
G
F
P
------
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
----
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
----
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
--
A
--
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
R
S
M
V
E
A
---------
109
HHSearch
54.89
44%
-108
- C3 -
1MV5
3
LMRA_LACLA
A:
[2-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
-
D
D
--
S
--
E
Q
-
I
--
L
--
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
--
I
S
L
-
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
-
A
G
T
I
R
E
N
L
T
Y
G
---
L
E
G
D--
Y
-
T
D
E
D
L
W
Q
V
L
D
-
L
A
F
A
R
S
F
V
E
N
M
P
------
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
----
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
----
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
--
A
--
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
--
P
L
Y
A
K
Y
V
S
E
Q
--------
55
PsiBlast_CBE
54.66
37%
-94
- C3 -
4Q4A
2
?
A:
[330-579]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---
N
------
A
----
L
A
L
P
N
V
E
--
G
S
V
S
F
E
N
V
E
F
R
Y
-
F
E
--
N
--
T
D
P
V
--
L
--
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
R
T
--
V
K
L
-
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
-
S
G
T
I
K
E
N
L
K
W
G
---
R
E
D
---
A
-
T
D
D
E
I
V
E
A
A
K
-
I
A
Q
I
H
D
F
I
I
S
L
P
E
------
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
----
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
--
K
----
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
--
A
--
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
--
C
--
K
P
Y
R
E
I
Y
E
S
Q
F
-------
57
PsiBlast_CBE
53.16
38%
-101
- C3 -
3VX4
3
?
D:
[33-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
S
F
E
N
L
S
Y
K
Y
-
G
F
--
G
--
R
D
-
T
--
L
--
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
--
I
D
K
-
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
-
S
G
S
I
M
D
N
L
V
L
G
A--
K
E
G
---
T
-
S
Q
E
D
I
I
-------
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
----
L
T
E
K
K
I
I
S
N
L
L
Q
M
T
--
E
-----
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
--
T
--
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
--
G
F
Y
Y
N
L
F
N
----------
26
PsiBlast_CBE
52.91
44%
-109
- C3 -
5DGX
1
?
A:
[17-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
V
T
I
K
D
L
S
F
A
F
-
G
E
--
H
--
K
--
V
--
L
--
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
---
E
G
E
I
L
L
D
G
V
D
T
R
E
--
L
T
L
-
E
N
L
R
S
H
L
S
I
V
S
Q
N
V
H
L
F
-
D
D
T
V
Y
N
N
I
A
F
G
-----
E
---
V
-
S
E
E
E
V
I
D
A
L
K
-
R
A
N
A
Y
E
F
V
Q
E
L
S
D
------
G
I
N
T
N
I
G
N
N
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
--------------------
L
E
S
L
T
--
K
----
S
C
T
T
I
V
I
A
H
R
L
S
T
V
E
N
--
A
--
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
E
Q
--
G
--
G
L
Y
T
R
L
Y
Q
----------
69
PsiBlast_CBE
52.19
37%
-93
- C3 -
2IXE
4
TAP1_RAT
A:
[10-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
N
M
-
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
--
H
--
P
N
-
V
QV
L
--
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
-
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
---
L
T
R
---
T
-
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
------
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
--
W
--
A
----
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
--
A
--
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
---------------
58
PsiBlast_CBE
51.97
38%
-99
- C3 -
3VX4
3
?
A:
[33-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
S
F
E
N
L
S
Y
K
Y
-
G
F
--
G
--
R
D
-
T
--
L
--
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
--
I
D
K
-
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
-
S
G
S
I
M
D
N
L
V
L
G
A--
K
E
G
---
T
-
S
Q
E
D
I
I
-------
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
----
L
T
E
K
K
I
I
S
N
L
L
Q
M
T
--
E
-----
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
--
T
--
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
--
G
F
Y
Y
N
L
F
N
----------
54
PsiBlast_CBE
51.73
43%
-105
- C3 -
1MV5
3
LMRA_LACLA
A:
[6-238]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
D
F
A
Y
-
D
D
--
S
--
E
Q
-
I
--
L
--
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
--
I
S
L
-
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
-
A
G
T
I
R
E
N
L
T
Y
G
---
L
E
G
---
D
Y
T
D
E
D
L
W
Q
V
L
D
-
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
------
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
----
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
----
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
--
A
--
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
--
P
L
Y
A
K
Y
V
S
E
Q
--------
53
PsiBlast_CBE
51.62
43%
-98
- C3 -
1MV5
2
LMRA_LACLA
B:
[6-238]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
D
F
A
Y
-
D
D
--
S
--
E
Q
-
I
--
L
--
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
--
I
S
L
-
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
-
A
G
T
I
R
E
N
L
T
Y
G
---
L
E
G
---
D
Y
T
D
E
D
L
W
Q
V
L
D
-
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
------
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
----
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
----
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
--
A
--
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
--
P
L
Y
A
K
Y
V
S
E
Q
--------
64
PsiBlast_CBE
51.44
38%
-95
- C3 -
2IXF
4
TAP1_RAT
C:
[10-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
N
M
-
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
--
H
--
P
N
-
V
QV
L
--
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
-
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
---
L
T
R
---
T
-
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
------
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
--
W
--
A
----
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
--
A
--
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
---------------
108
HHSearch
50.32
34%
-96
- C3 -
3VX4
3
?
A:
[29-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
L
D
--
G
D
I
S
F
E
N
L
S
Y
K
Y
-
G
F
--
G
--
R
D
-
T
--
L
--
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
--
I
D
K
-
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
-
S
G
S
I
M
D
N
L
V
L
G
---
A
K
E
G--
T
-
S
Q
E
D
I
I
R
A
C
E
-
I
A
E
I
R
S
D
I
E
Q
M
P
------
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
----
L
T
E
K
K
I
I
S
N
L
L
Q
M
---
T
----
E
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
--
T
--
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
--
G
F
Y
Y
N
L
F
N
----------
68
PsiBlast_CBE
50.25
37%
-100
- C3 -
2IXE
3
D:
[10-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
N
M
-
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
--
H
--
P
N
-
V
QV
L
--
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
-
H
Y
L
H
T
Q
V
A
A
V
G
--
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
---
L
T
R
---
T
-
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
------
Q
G
Y
D
T
E
V
-----
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
GNQL
R
V
Q
R
L
L
Y
E
S
P
E
--
W
--
A
----
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
--
A
--
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
---------------
66
PsiBlast_CBE
50.23
38%
-94
- C3 -
2IXF
5
TAP1_RAT
A:
[10-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
N
M
-
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
--
H
--
P
N
-
V
QV
L
--
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
-
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
---
L
T
R
---
T
-
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
------
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
--
W
--
A
----
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
--
A
--
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
---------------
65
PsiBlast_CBE
50.18
38%
-95
- C3 -
2IXF
4
TAP1_RAT
B:
[10-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
N
M
-
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
--
H
--
P
N
-
V
QV
L
--
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
-
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
---
L
T
R
---
T
-
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
------
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
--
W
--
A
----
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
--
A
--
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
---------------
63
PsiBlast_CBE
49.89
38%
-94
- C3 -
2IXF
4
D:
[10-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
N
M
-
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
--
H
--
P
N
-
V
QV
L
--
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
-
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
---
L
T
R
---
T
-
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
------
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
GNQL
R
V
Q
R
L
L
Y
E
S
P
E
--
W
--
A
----
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
--
A
--
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
---------------
52
PsiBlast_CBE
49.80
43%
-101
- C3 -
1MV5
3
LMRA_LACLA
C:
[6-238]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
D
F
A
Y
-
D
D
--
S
--
E
Q
-
I
--
L
--
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
--
I
S
L
-
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
-
A
G
T
I
R
E
N
L
T
Y
G
---
L
E
G
---
D
Y
T
D
E
D
L
W
Q
V
L
D
-
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
------
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
----
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
----
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
--
A
--
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
--
P
L
Y
A
K
Y
V
S
E
Q
--------
70
PsiBlast_CBE
49.45
37%
-95
- C3 -
4K8O
4
A:
[10-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
N
M
-
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
--
H
--
P
N
-
V
QV
L
--
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
-
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
---
L
T
R
---
T
-
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
------
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
A
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
--
W
--
A
----
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
--
A
--
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
---------------
71
PsiBlast_CBE
48.70
36%
-96
- C3 -
2IXG
2
A:
[10-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
N
M
-
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
--
H
--
P
N
-
V
QV
L
--
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
-
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
---
L
T
R
---
T
-
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
------
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
A
V
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
--
W
--
A
----
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
--
A
--
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
---------------
51
PsiBlast_CBE
48.33
43%
-102
- C3 -
1MV5
3
D:
[6-238]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
D
F
A
Y
-
D
D
--
S
--
E
Q
-
I
--
L
--
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
--
I
S
L
-
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
-
A
G
T
I
R
E
N
L
T
Y
G
---
L
E
G
---
D
Y
T
D
E
D
L
W
Q
V
L
D
-
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
------
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
----
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
----
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
--
A
--
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
--
P
L
Y
A
K
Y
V
S
E
Q
--------
67
PsiBlast_CBE
48.30
38%
-87
- C3 -
1JJ7
2
A:
[8-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
H
L
E
---
G
L
V
Q
F
Q
D
V
S
F
A
Y
-
P
N
--
R
--
P
D
-
V
--
L
VL
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
Q
L
L
L
D
G
K
P
L
P
Q
--
Y
E
H
-
R
Y
L
H
R
Q
V
A
A
V
G
Q
E
P
Q
V
F
-
G
R
S
L
Q
E
N
I
A
Y
G
LTQ
K
P
------
T
M
E
E
I
T
A
A
A
V
-
K
S
G
A
H
S
F
I
S
G
L
P
------
Q
G
Y
D
T
E
V
D
E
A
G
S
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
C
V
L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
L
Q
V
E
Q
L
L
Y
E
S
P
E
R
Y
--------
S
R
S
V
L
L
I
T
Q
H
L
S
L
V
E
Q
--
A
--
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
Q
L
M
E
K
--
K
--
G
C
Y
---------------
76
PsiBlast_CBE
39.68
33%
-85
- C3 -
4U00
3
?
A:
[19-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
L
--
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
---
E
G
E
V
V
V
D
G
L
S
V
K
D
--
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
---
P
M
R
---
V
-
R
R
W
P
R
E
K
A
E
K
-
K
A
-----
L
E
L
L
E
----
R
-
V
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
D
V
M
R
D
L
A
--
Q
G
---
G
M
T
M
V
V
V
T
H
E
M
G
-
F
A
R
E
V
A
--
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
----------
I
F
T
R
P
K
E
E
R
T
R
S
F
L
---
88
PsiBlast_CBE
37.59
33%
-86
- C3 -
4YMU
2
?
A:
[16-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
N
N
GK
V
N
I
-
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
---
P
V
-------------
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
-
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
---
V
K
E
V
L
N
V
M
K
--
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
-
F
A
R
--
E
VG
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------
87
PsiBlast_CBE
37.29
33%
-83
- C3 -
4YMU
2
?
J:
[16-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
N
N
GK
V
N
I
-
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
---
P
V
-------------
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
-
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
---
V
K
E
V
L
N
V
M
K
--
Q
LANE
G
M
T
M
V
V
V
T
H
E
M
G
-
F
A
R
--
E
VG
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------
85
PsiBlast_CBE
37.10
33%
-83
- C3 -
4YMV
1
?
J:
[16-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
N
N
GK
V
N
I
-
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
---
P
V
-------------
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
-
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
---
V
K
E
V
L
N
V
M
K
--
Q
LANE
G
M
T
M
V
V
V
T
H
E
M
G
-
F
A
R
--
E
VG
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------
86
PsiBlast_CBE
36.54
33%
-82
- C3 -
4YMV
1
?
A:
[16-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
N
N
GK
V
N
I
-
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
---
P
V
-------------
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
-
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
---
V
K
E
V
L
N
V
M
K
--
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
-
F
A
R
--
E
VG
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------