@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3331: (2016-02-16 )
MPDRKLRLGEELISPLHALYDGLQVDGAPRPAHRAAEHPVWVVTRYRDARKVLNHPGVRRDARQAAELYAKRTGSPRAGIGEGLSHHMLNLDPPDHTRLRSLVGRAFTPRQVERLQPHIERITEALLDAMAGREQADLMADFAIPLTIAVIFELLGIPEAEREHARQSWERQAELLSPEEAQALADAQVDYLRVLLEAKRRQPADDVYSGLVQAADESGQLSEAELVSMAHLLMMSGFETTMNMIGNALVTLLVNPEQLALLRAQPELLPNAMEELVRHDSPVRASMLRFTVEDVELDGVTIPAGEYILVSNLTANHDAERFDDPDRLDLTRNTDGHLGYGFGVHYCVGASLARLEGRIAIQRLLARFPDLQLAVPHAELQWLPITFLRALISVPVRTGCSAPANTASHANPIERIAQ
Atome Classification :
(38 SA)
.........10........20........30......---.--.40........50......-..60....---....-.70........80........90........100.......110.......120.......130.........140.......150.......160-.......170.......-180......---.-190.......200.......210....-..-.-220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPD
R
K
L
R
L
G
E
E
L
I
S
P
L
H
A
L
YD
G
L
QVDGAPRPAHRAAE---H--
P
V
W
V
V
T
R
Y
R
D
A
R
K
V
LNHPG-V
R
R
-
D
A
R
Q
---
A
A
E
L
-
Y
A
KRTGSPRA
G
I
G
E
G
L
S
H
HMLNLDPP
D
H
T
R
L
R
S
L
VGRAF
T
P
R
Q
V
E
R
L
Q
P
H
I
E
R
I
T
E
A
L
L
D
A
M--AG
R
E
Q
A
D
L
M
A
DFA
I
P
L
T
I
A
V
I
F
E
L
LGIP
E
A
E
R
-
E
H
A
R
Q
S
W
E
R
Q
A
ELL
S
P
E
-
E
A
Q
A
L
A
D
A
Q
---
V
-
D
Y
L
R
V
L
L
E
A
KRRQ
P
A
D
D
V
Y
S
G
L
V
Q
AAD-ES-G-Q
L
S
E
A
E
L
V
S
M
A
H
L
L
M
MSG
F
E
T
T
M
N
M
I
G
N
A
L
V
T
L
L
V
N
P
E
Q
L
A
L
L
RAQ
P
E
L
L
P
N
A
M
E
E
L
V
RHDSP
V
R
A
S
M
L
R
F
T
V
E
D
V
E
LD
G
V
T
IPAG
E
Y
I
L
V
S
NLTANH
D
A
ERFDDPDRLDLTRNTDG
H
L
G
YGF
G
V
H
Y
C
V
G
A
S
L
A
R
L
E
G
R
I
A
I
Q
R
L
L
A
RFPD
L
Q
L
AVPHAE
L
Q
W
L
P
I
T
F
L
R
A
L
ISVPVRTGCSAPANTASH
A
N
P
I
E
R
IAQ
4
PsiBlast_PDB
93.01
43%
-105
- C4 -
2VZM
2
PIKC_STRVZ
A:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
33
PsiBlast_CBE
92.93
43%
-106
- C4 -
4BF4
17
PIKC_STRVZ
G:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LA
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
10
PsiBlast_PDB
92.62
43%
-109
- C4 -
2BVJ
3
PIKC_STRVZ
A:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
D
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
42
PsiBlast_CBE
92.50
43%
-103
- C4 -
2VZM
2
PIKC_STRVZ
B:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
41
PsiBlast_CBE
92.40
43%
-106
- C4 -
3ZK5
2
PIKC_STRVZ
B:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
5
PsiBlast_PDB
92.29
43%
-105
- C4 -
4B7S
14
PIKC_STRVZ
A:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
15
PsiBlast_PDB
92.28
43%
-104
- C4 -
4B7D
3
PIKC_STRVZ
A:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PE
G
D
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
1
PsiBlast_PDB
92.26
43%
-104
- C4 -
2WHW
2
PIKC_STRVZ
A:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PE
G
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
3
PsiBlast_PDB
92.08
43%
-106
- C4 -
2VZ7
2
PIKC_STRVZ
A:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PE
G
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
9
PsiBlast_PDB
92.07
43%
-103
- C4 -
4UMZ
2
PIKC_STRVZ
A:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PE
G
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
2
PsiBlast_PDB
92.07
43%
-106
- C4 -
2WI9
2
PIKC_STRVZ
A:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PE
G
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
23
PsiBlast_CBE
92.05
43%
-104
- C4 -
4UMZ
2
PIKC_STRVZ
B:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PE
G
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
37
PsiBlast_CBE
91.87
43%
-104
- C4 -
4BF4
2
PIKC_STRVZ
C:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LA
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
40
PsiBlast_CBE
91.75
43%
-104
- C4 -
3ZPI
6
PIKC_STRVZ
B:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PE
G
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
32
PsiBlast_CBE
91.74
43%
-106
- C4 -
4BF4
1
PIKC_STRVZ
H:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LA
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
38
PsiBlast_CBE
91.73
43%
-105
- C4 -
4BF4
3
PIKC_STRVZ
B:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
47
PsiBlast_CBE
91.68
43%
-105
- C4 -
2C6H
3
PIKC_STRVZ
B:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
D
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LA
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
25
PsiBlast_CBE
91.68
43%
-105
- C4 -
4BF4
17
PIKC_STRVZ
O:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LA
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
36
PsiBlast_CBE
91.57
43%
-105
- C4 -
4BF4
19
PIKC_STRVZ
D:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LA
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
44
PsiBlast_CBE
91.45
43%
-103
- C4 -
4B7D
4
PIKC_STRVZ
B:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
D
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LA
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
12
PsiBlast_PDB
91.38
43%
-106
- C4 -
2C7X
2
PIKC_STRVZ
A:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
D
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
6
PsiBlast_PDB
91.38
43%
-103
- C4 -
3ZK5
2
PIKC_STRVZ
A:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
11
PsiBlast_PDB
91.24
43%
-104
- C4 -
2C6H
6
PIKC_STRVZ
A:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
D
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
39
PsiBlast_CBE
91.20
43%
-103
- C4 -
4B7S
6
PIKC_STRVZ
B:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
22
PsiBlast_CBE
91.10
43%
-101
- C4 -
2WHW
4
PIKC_STRVZ
B:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PE
G
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
48
PsiBlast_CBE
91.06
43%
-108
- C4 -
2BVJ
3
PIKC_STRVZ
B:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PE
G
D
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
------
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
7
PsiBlast_PDB
90.81
43%
-104
- C4 -
3ZPI
13
PIKC_STRVZ
A:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
21
PsiBlast_CBE
90.74
43%
-102
- C4 -
2WI9
5
PIKC_STRVZ
B:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
43
PsiBlast_CBE
90.63
43%
-101
- C4 -
2VZ7
2
PIKC_STRVZ
B:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
N
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
66
PsiBlast_CBE
90.08
38%
-104
- C4 -
1Z8Q
3
CPXJ_SACEN
A:
[27-401]
---------------------------
A
P
V
T
P
V
R
F
L
G
---
Q
--
D
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
-
L
S
S
-
D
P
K
K
KYP
G
V
E
V
E
F
P
A
Y
L
G
F
P
E
-
D
V
R
N
Y
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
--
G
D
S
G
V
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
--
W
S
S
E
I
L
V
M
D
P
E
-
R
A
E
Q
R
G
Q
A
A
R
E
V
V
-
N
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
R
V
Q
D
-
D
D
D
G
-
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
T
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
E
T
T
T
-
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
R
---------------------
45
PsiBlast_CBE
90.04
43%
-104
- C4 -
2CD8
2
PIKC_STRVZ
B:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
D
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LA
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
14
PsiBlast_PDB
89.71
43%
-102
- C4 -
2CD8
2
PIKC_STRVZ
A:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PE
G
D
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
13
PsiBlast_PDB
89.48
43%
-103
- C4 -
2CA0
2
PIKC_STRVZ
A:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
D
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------
17
PsiBlast_PDB
88.41
42%
-110
- C4 -
3A4H
2
CPVDH_PSEAH
A:
[42-399]
------------------------------------
D
---
G
--
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
-
L
S
K
-
D
W
R
H
---
T
L
-------
P
E
D
Q
R
A
D
M
P
A
T
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
--
P
T
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
-
D
D
F
-
S
A
W
S
S
V
L
V
D
D
S
P
A
-
D
D
K
N
A
A
M
G
K
---
L
H
G
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
-
E
D
-
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
P
I
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
-------------------
16
PsiBlast_PDB
87.96
42%
-106
- C4 -
3A4G
2
CPVDH_PSEAH
A:
[42-399]
------------------------------------
D
---
G
--
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
-
L
S
K
-
D
W
R
H
---
T
L
-------
P
E
D
Q
R
A
D
M
P
A
T
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
--
P
T
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
-
D
D
F
-
S
A
W
S
S
V
L
V
D
D
S
P
A
-
D
D
K
N
A
A
M
G
K
---
L
H
G
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
-
E
D
-
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
P
I
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
-------------------
18
PsiBlast_PDB
87.42
42%
-111
- C4 -
3VRM
2
CPVDH_PSEAH
A:
[42-399]
------------------------------------
D
---
G
--
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
-
L
S
K
-
D
W
R
H
---
T
L
-------
P
E
D
Q
R
A
D
M
P
A
T
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
A
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
--
P
T
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
-
D
D
F
-
S
A
W
S
S
V
L
V
D
D
S
P
A
-
D
D
K
N
A
A
M
G
K
---
L
H
G
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
-
E
D
-
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
P
I
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
-------------------
137
HHSearch
87.21
40%
-96
- C4 -
3A4G
2
CPVDH_PSEAH
A:
[15-403]
--------
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
-
E
--
D
P
V
R
K
L
A
L
---
P
D
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
D
W
R
H
T
L
---
P
--
E
-
D
Q
R
--
A
D
----
M
P
A
T
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
--
P
T
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
-
D
D
F
S
-
A
W
S
S
V
L
V
D
D
S
P
A
D
D
K
N
A
A
M
G
K
L
---
H
-
G
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
E
D
G
-
D
-
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
P
I
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
P
R
S
A
---------------
46
PsiBlast_CBE
86.86
43%
-100
- C4 -
2CA0
2
PIKC_STRVZ
B:
[40-424]
-------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
---
P
A
H
R
V
R
T
PEG
D
--
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
-
D
W
R
N
---
S
T
---------
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LA
A
P
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
-
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
-
Q
A
Q
T
A
M
A
E
M
---
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
-
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---------------------