@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3394: (2016-02-16 )
MSLVEIDGATLRYGALTALSGLDLRLEPGEVLGLLGHNGAGKTTTIKLVLGLLAPSEGRVRVLGHDARSLEARRQLGYLPENVTFYPQLSGAETLRHFARLKGVAPAEAARLLEQVGLGHAARRRLKTYSKGMRQRLGLAQALLGEPRLLLLDEPTVGLDPLATVELYQLLDRLRGQGTGIVLCSHVLPGVETHIDRAAILAGGRLQVAGSLAELRRKAALPTRVRLASPHNPQWLERWHRAGLAARRLDDQRIEVLLDDAERDGVLEALLAAREFDLEILPPSLEDLYRHHMSPAPAGATPCP
Atome Classification :
(22 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10..--..----....20........30........40........50........60...---..-...------70-----.-.-.-..----....80..-...-----.-------..90....-------..--..100---------..-.----.----...-----.110----.....----...120.......----130.......140.......150.......160.......170...-..-..180.-......190.......200.......210.......220.......230.......240.......250.......---260.......270.......280.......290.......300..----------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
S
L
V
EIDG
A
T
L
R
Y
--
G
A
----
L
T
ALSG
L
D
L
RLEPG
E
V
L
G
LLGHNGAGK
T
T
T
I
K
L
V
L
G
L
LAPSE
G
R
V
R
V
LG---HD-
A
R
S
------
L
------
E
-
A
-
R
-
R
Q----LGYLPEN
V
-
T
F
Y-----P-------QLS
G
A
E
T
L
-------
R
H
--
F
A
R
L----------KG-V----
A
----
P
A
E
-----
A
A
R
-----
L
L
E
Q
V----GL
G
H
A
A
R
R
R
L
K
T
Y
----
S
K
G
M
R
Q
R
L
G
L
A
Q
A
L
LGEP
R
L
L
L
L
DEPTVGLDP
L
A
T
V
E
L
Y
Q
L
L
D
R
LR-GQ-G
T
G
I
V
L
-
C
S
H
VLP
G
V
E
T
H
I
D
R
A
A
I
LAG
G
R
L
Q
V
A
G
S
L
A
E
L
R
R
KAALP
T
R
V
R
LASPH
N
P
Q
W
L
E
R
W
H
R
AG
L
A
A
RRLD
D
Q
R
I
E
V
L
LD---DAERD
G
V
L
E
A
L
L
A
A
R
EFDLEILPP
S
L
E
D
L
Y
R
HHMSPAPAGATPCP----------------------------------------
59
HHSearch
88.08
38%
-111
- C1 -
1VPL
2
?
A:
[15-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
V
V
K
D
L
R
K
R
I
--
G
K
----
K
E
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
T
V
F
G
---
K
N
-
V
V
E
E
P
----
H
------
E
-
V
-
R
-
K
L
----
I
S
Y
L
P
E
E
A
-
G
A
Y
-----
R
-------
N
M
Q
G
I
E
Y
L
-------
R
F
--
V
A
G
F
----------
Y
A
-
S
----
S
S
S
E
I
E
E
M
-----
V
E
R
-----
A
T
E
I
A
----
G
L
G
E
K
I
K
D
R
V
S
T
Y
----
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
K
Q
A
S
-
Q
E
-
G
L
T
I
L
V
-
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
E
T
G
T
V
E
E
L
K
E
----------------------------------------------------------------------------------------------------------------------------------
62
Fugue
84.16
26%
-76
- C1 -
1Z47
1
?
A:
[11-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P-
G
G
----
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
---
K
R
-
V
T
D
------
L
P-----
P
-
Q
-
K
-
R
N
----
V
G
L
V
F
Q
N
Y
-
A
L
F
-----
Q
-------
H
M
T
V
Y
D
N
V
-------
S
F
--
G
L
R
E
----------
K
R
-
V
P
K
D
E
M
----
D
A
R
-----
V
R
E
-----
L
L
R
F
M
----
R
L
E
S
Y
A
N
R
F
P
H
E
L
----
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
-
D
E
M
G
V
T
S
V
F
-
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
---
P
G
T
L
F
V
A
S
F
I
G
E
S
---
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
A
G
A
A
L
P
V
D
---
P
A
V
S
E
G
S
-
E
V
A
V
V
V
R
P
K
D
V
E
L
Q
P
A
S
E
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
1
PsiBlast_PDB
84.13
37%
-104
- C1 -
1VPL
2
?
A:
[24-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
--
G
K
----
K
E
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
T
V
F
G
---
K
N
-
V
V
E
------
E
P
H
----
E
-
V
-
R
-
K
L
----
I
S
Y
L
P
E
E
A
-
G
A
Y
-----
R
-------
N
M
Q
G
I
E
Y
L
-------
R
F
--
V
A
G
F
----------
Y
A
-
S
----
S
----
S
S
E
-----
I
E
E
-----
M
V
E
R
A
T
E
I
A
G
L
G
E
K
I
K
D
R
V
S
T
Y
----
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
K
Q
A
S
-
Q
E
-
G
L
T
I
L
V
-
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
E
T
G
T
V
E
E
L
K
E
R
---------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.73
36%
-108
- C1 -
4RVC
-
?
A:
[2-227]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
L
E
V
K
D
L
S
G
G
Y
--
T
A
----
Q
N
V
L
E
D
V
T
F
V
V
D
R
G
E
M
V
A
L
I
G
L
N
G
A
G
K
S
T
T
I
K
H
I
I
G
L
M
E
P
R
R
G
A
I
S
I
N
G
---
Y
R
L
A
D
G
------
P
------
E
-
T
Y
R
-
R
Q
----
F
A
Y
I
P
E
T
P
-
V
L
Y
-----
E
-------
E
L
T
L
E
E
H
L
-------
R
L
--
A
A
M
A
----------
Y
G
-
L
----
S
----
E
A
E
-----
Y
E
R
-----
R
L
P
P
L
----
L
R
E
F
R
L
E
R
R
L
S
S
F
PAHF
S
K
G
M
K
Q
K
V
M
I
V
C
A
F
L
L
E
P
P
L
Y
I
I
D
E
P
F
L
G
L
D
P
L
A
I
H
A
L
L
E
R
M
N
E
Q
K
-
A
K
-
G
A
G
I
L
L
-
S
T
H
I
L
A
T
A
E
R
Y
C
D
S
F
V
I
L
H
N
G
R
V
K
A
K
G
T
L
D
D
I
R
R
Q
F
G
L
------------------------------------------------------------------------------------------------------------------------------
61
Fugue
73.77
22%
-98
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
--
H
Q
GTRT
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
---
Q
E
-
L
T
T
------
L
SESELT
K
-
A
-
R
-
R
Q
----
I
G
M
I
F
Q
H
F
-
N
L
L
-----
S
-------
S
R
T
V
F
G
N
V
-------
A
L
--
P
L
E
L
----------
D
N
-
T
PKDE
V
----
K
R
R
-----
V
T
E
-----
L
L
S
L
V
----
G
L
G
D
K
H
D
S
Y
P
S
N
L
----
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
R
L
G
L
T
I
L
L
-
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
FTG
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
QDTQAAIAWLQEHHVKVEV---------------------
12
PsiBlast_PDB
73.24
29%
-101
- C1 -
3D31
-
?
A:
[1-226]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
E
I
E
S
L
S
R
K
W
--
K
N
----
F
S
-
L
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
G
R
I
L
L
D
G
---
K
D
-
V
T
D
------
L
------
S
P
E
-
K
-
H
D
----
I
A
F
V
Y
Q
N
Y
-
S
L
F
-----
P
-------
H
M
N
V
K
K
N
L
-------
E
F
--
G
M
R
M
----------
K
K
-
I
----
K
D---
P
K
R
-----
V
L
D
-----
T
A
R
D
L
----
K
I
E
H
L
L
D
R
N
P
L
T
L
----
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
-
K
K
-
N
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
---
P
V
E
G
R
V
A
S
----------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.83
27%
-106
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[23-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
------
F
D
-
N
K
P
------
I
------
D
Y
S
-
R
-
K
G
----
I
M
K
L
R
E
S
I
-
G
I
V
F
QDPD
N
-------
Q
L
F
S
A
S
V
Y
-------
Q
D
V
S
F
G
A
V
----------
N
M
-
K
----
L
----
P
E
D
-----
E
I
R
K
R
V
D
N
A
L
K
R
T
----
G
I
E
H
L
K
D
K
P
T
H
C
L
----
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
-
K
E
L
G
I
T
I
I
I
-
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
K
E
V
I
R
K
V
N
L
R
L
P
R
I
G
H
L
M
E
I
-------------------------------------------------------------------------------------------------------------
49
HHSearch
71.47
28%
-109
* C1 *
3TUI
1
METN_ECOLI
C:
[23-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
--
H
Q
GTRT
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
---
Q
E
-
L
T
T
LSESEL
T
------
K
-
A
-
R
-
R
Q
----
I
G
M
I
F
Q
H
F
-
N
L
L
-----
S
-------
S
R
T
V
F
G
N
V
-------
A
L
--
P
L
E
L
----------
D
N
-
T
----
P
KDEV
K
R
R
-----
V
T
E
-----
L
L
S
L
V
----
G
L
G
D
K
H
D
S
Y
P
S
N
L
----
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
-
G
L
T
I
L
L
-
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
----------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
70.53
26%
-106
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
I
L
K
V
E
E
L
N
Y
N
Y
--
S
D
G---
T
H
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
---
K
P
-
I
D
Y
S
R
K
G
I
-
M
------
K
-
L
-
R
-
E
S
----
I
G
I
V
F
Q
D
P
D
N
Q
L
-----
F
-------
S
A
S
V
Y
Q
D
V
-------
S
F
--
G
A
V
N
----------
M
K
-
L
----
P
E
D
E
I
R
K
R
-----
V
D
N
-----
A
L
K
R
T
----
G
I
E
H
L
K
D
K
P
T
H
C
L
----
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
-
G
I
T
I
I
I
-
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
----------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
70.28
26%
-100
- C1 -
2OLJ
4
?
A:
[22-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
-
L
K
A
KDTN
L
-
N
------
K
-
V
-
R
-
E
E
----
V
G
M
V
F
Q
R
F
-
N
L
F
-----
P
-------
H
M
T
V
L
N
N
I
-------
T
L
--
A
P
M
K
----------
V
R
K
W
P
R
E
K
A
----
E
A
K
-----
A
M
E
-----
L
L
D
K
V
----
G
L
K
D
K
A
H
A
Y
P
D
S
L
----
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
----------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
68.59
30%
-103
- C1 -
4P32
2
LPTB_ECOLI
A:
[12-223]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
K
G
----
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
---
D
D
-
I
S
L
------
L
P
L
H
A
--
R
-
A
-
R
-
R
G
----
I
G
Y
L
P
Q
E
A
-
S
I
F
-----
R
-------
R
L
S
V
Y
D
N
L
-------
M
A
--
V
L
Q
I
----------
R
D
-
D
----
L
----
S
A
E
Q
R
E
D
R
A
N
E
-----
L
M
E
E
F
----
H
I
E
H
L
R
D
S
M
G
Q
S
L
----
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
-
D
S
-
G
L
G
V
L
I
-
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
68.48
32%
-105
- C1 -
4U02
1
?
B:
[14-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
G
P
----
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
LSV
K
D
-
D
R
A
------
L
R-----
E
-
I
-
R
-
R
E
----
V
G
M
V
F
Q
Q
F
-
N
L
F
-----
P
-------
H
M
T
V
L
E
N
V
TLAPMRV
R
R
--
W
P
R
E
----------
K
-------
A
----
E
K
K
-----
A
L
E
-----
L
L
E
R
V
----
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
----
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
G
-
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
------------------------------------------------------------------------------------------------------------------------------------
65
Fugue
68.33
25%
-91
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
PFK
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
LKPLLDDGFGKTDRSVLLW
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
MPVAFFDKQS
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
FYYS
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
KEVLIFGG
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
FPSVMDSLT
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
SEQEK
D
E
G
K
RVIDRA
T
G
D
L
E
F
R
N
V
T
F
T
Y
PG
R
E
----
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
---
H
D
-
L
R
E
------
Y
T
L
A
---
S
-
L
-
R
-
N
Q
----
V
A
L
V
S
Q
N
V
-
H
L
F
-----
N
DT
V
A
N
N
I
A
Y
A
R
T
E
E
Y
-------
S
R
--
E
Q
I
E
----------
E
A
-
A
----
R
----
M
A
Y
-----
A
M
D
-----
F
I
N
K
M
DN--
G
L
D
T
I
I
G
E
N
G
V
L
L
----
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
N
-
R
T
S
L
V
I
-
A
-
H
R
L
S
T
I
E
-
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
------------------------------------------------------------------
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
--------------------------------------------------
8
PsiBlast_PDB
68.16
32%
-103
- C1 -
4U00
3
?
A:
[14-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
G
P
----
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
LSV
K
D
-
D
R
A
------
L
R
-----
E
-
I
-
R
-
R
E
----
V
G
M
V
F
Q
Q
F
-
N
L
F
-----
P
-------
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
--
W
P
R
E
----------
K
-------
A
----
E
K
K
-----
A
L
E
-----
L
L
E
R
V
----
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
----
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
G
-
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
67.82
32%
-102
- C1 -
4U02
1
?
D:
[14-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
G
P
----
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
LSV
K
D
-
D
R
A
------
L
R-----
E
-
I
-
R
-
R
E
----
V
G
M
V
F
Q
Q
F
-
N
L
F
-----
P
-------
H
M
T
V
L
E
N
V
TLAPMRV
R
R
--
W
P
R
E
----------
K
-------
A
----
E
K
K
-----
A
L
E
-----
L
L
E
R
V
----
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
----
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
G
-
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
67.48
32%
-103
- C1 -
4U02
1
?
A:
[14-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
G
P
----
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
LSV
K
D
-
D
R
A
------
L
R
-----
E
-
I
-
R
-
R
E
----
V
G
M
V
F
Q
Q
F
-
N
L
F
-----
P
-------
H
M
T
V
L
E
N
V
T
LAPMRV
R
R
--
W
P
R
E
----------
K
-------
A
----
E
K
K
-----
A
L
E
-----
L
L
E
R
V
----
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
----
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
G
-
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
67.38
27%
-99
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-223]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
----
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
-
M
N
D
T-----
P
------
P
-
A
-
E
-
R
G
----
V
G
M
V
F
Q
S
Y
-
A
L
Y
-----
P
-------
H
L
S
V
A
E
N
M
-------
S
F
--
G
L
K
L
----------
A
G
-
A
----
K
K
E
V
I
N
Q
R
-----
V
N
Q
-----
V
A
E
V
L
----
Q
L
A
H
L
L
D
R
K
P
K
A
L
----
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
-
G
R
T
M
I
Y
-
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
----------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
67.38
27%
-92
- C1 -
2IT1
-
?
A:
[1-224]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
E
I
K
L
E
N
I
V
K
K
F
--
G
N
----
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
---
K
D
-
V
T
E
------
L
------
P
-
P
-
K
D
R
N
----
V
G
L
V
F
Q
N
W
-
A
L
Y
-----
P
-------
H
M
T
V
Y
K
N
I
-------
A
F
--
P
L
E
L
----------
R
K
-
A
----
P
----
R
E
E
-----
I
D
K
-----
K
V
R
E
V
----
A
K
M
L
H
I
D
K
L
L
N
R
Y
PWQL
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
-
K
E
L
G
I
T
T
V
Y
-
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
---------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
67.36
30%
-101
- C1 -
4P33
7
LPTB_ECOLI
A:
[12-223]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
K
G
----
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
---
D
D
-
I
S
L
------
L
P
L
H
A
--
R
-
A
-
R
-
R
G
----
I
G
Y
L
P
Q
E
A
-
S
I
F
-----
R
-------
R
L
S
V
Y
D
N
L
-------
M
A
--
V
L
Q
I
----------
R
D
-
D
----
L
----
S
A
E
Q
R
E
D
R
A
N
E
-----
L
M
E
E
F
----
H
I
E
H
L
R
D
S
M
G
Q
S
L
----
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
Q
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
-
D
S
-
G
L
G
V
L
I
-
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.92
29%
-103
- C1 -
4WBS
1
?
A:
[48-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
--
G
S
----
R
T
V
V
K
D
V
S
L
D
V
K
S
G
E
V
V
G
L
L
G
P
N
G
A
G
K
T
T
S
F
Y
M
I
V
G
L
V
P
L
D
A
G
E
I
D
L
D
G
---
K
S
-
I
S
L
------
L
------
P
-
I
-
H
-
K
R
A
S
L
G
L
S
Y
L
P
Q
E
A
-
S
V
F
-----
R
-------
K
L
S
V
E
E
N
I
-------
R
A
--
V
L
E
L
QVGDDGKRLS
K
D
-
A
----
I
----
A
S
R
-----
T
E
A
-----
L
L
D
E
L
----
Q
I
S
H
L
R
E
N
P
A
L
S
L
----
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
T
N
P
S
F
I
L
L
D
E
P
F
A
G
V
D
P
I
A
V
L
E
I
Q
K
I
V
K
F
L
K
-
Q
R
-
N
I
G
V
L
I
-
T
D
H
N
V
R
E
T
L
G
I
C
D
H
A
Y
I
I
S
D
G
S
V
L
A
A
G
A
----------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
66.64
30%
-105
- C1 -
4QC2
2
?
A:
[13-224]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
K
G
----
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
---
D
D
-
I
S
L
------
L
P
L
H
A
--
R
-
A
-
R
-
R
G
----
I
G
Y
L
P
Q
E
A
-
S
I
F
-----
R
-------
R
L
S
V
Y
D
N
L
-------
M
A
--
V
L
Q
I
----------
R
D
-
D
----
L
----
S
A
E
Q
R
E
D
R
A
N
E
-----
L
M
E
E
F
----
H
I
E
H
L
R
D
S
M
G
Q
S
L
----
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
-
D
S
-
G
L
G
V
L
I
-
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
38.69
30%
-4
- C1 -
4P31
2
LPTB_ECOLI
A:
[12-223]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
K
G
----
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
---
D
D
-
I
S
L
------
L
P
L
H
A
--
R
-
A
-
R
-
R
G
----
I
G
Y
L
P
Q
E
A
-
S
I
F
-----
R
-------
R
L
S
V
Y
D
N
L
-------
M
A
--
V
L
Q
I
----------
R
D
-
D
----
L
----
S
A
E
Q
R
E
D
R
A
N
E
-----
L
M
E
E
F
----
H
I
E
H
L
R
D
S
M
G
Q
S
L
----
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
-
D
S
-
G
L
G
V
L
I
-
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
------------------------------------------------------------------------------------------------------------------------------------