@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3466: (2016-02-17 )
MPRSPLFSQFPLHERLLKALESLSFSEPTPVQAAAIPKALEGHDLRVTAQTGSGKTAAFLLPLLHRLLAEDKPRSLARALILLPTRELAQQTLKEVERFAQFTFIKACLITGGEDFKVQGARLRKNPEIIIGTPGRLLEQRNAGNLPLQDIEVLVLDEADRMLDMGFADDVLALANACPAERQTLLFSATHSGAGLNKVIAEVLREPQVLRLNQVGELNENVRQQVITADDVAHKEQLLQWLLSNETYTKAIVFTNTRVSADRLTGRLIANQHKVFVLHGEKDQKDRKLAIERLKQGAVKILVATDVAARGLDVEGLDLVINFDMPRSGDEYVHRIGRTGRAGAEGLAISLICHGDWNLMSSVERYLKQNFERRNIKELKAAYQGPKKLKASGKAAGSKKKKQDRKGAAAKPAAKRKPAARPKAGPSAVVSADGMAPLKRKKPTAE
Atome Classification :
(66 SA)
......--..-----.10........20........30........40-.--.--.......50........60...----...--.-.70-..---------------.--.-...--------.--.----------------80........90........100..----.---.---....-110--........-.-120....----.-...130.....--..140...-.....150-.........160.-.--.-.-...170----.----.......----.-------180.--.-.......190....---...200.......210...----.----...-220.......230.-..----.-----....240.......250.......260.......270--...----.....280.......290.......300.......310.......320.....------..330----.........340.......350-.-..-.-...360.......370.......380.......390.......400.......410.......420.......430.......440....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPRSPL--FS-----QF
P
L
H
E
R
L
L
K
A
L
E
SLSFSEPTPV
Q
A
A
AIPKAL--E--G--H
D
L
R
V
T
A
QTGSG
K
T
A
A
F
L
L
P
L
L
----
H
R
L
--L-AE--DK---------------
P
--
R
-
S
L
A
--------
R
--
A
----------------
L
ILLP
T
R
E
L
A
Q
Q
T
L
K
E
V
E
R
F
A
-
Q
F
T
----
F
---
I
---
K
A
C
L
-I----TGGED
F
K
V
-Q-GA-RLRK----N-P
E
I
I
IGT
P
G
R
L
--
L
E
Q-RNAG-NL
P
L
Q
D
---
I
E
V
L
V
LDEA
D
R
M
L
-D--M-G-F
A
D
D
------
V
----
L
A
L
A
NAC----P-------A--E--R-
Q
T
L
L
F
SATHSGA
G
L
---
N
K
V
I
A
E
V
LREP
Q
V
L
R
L
N
Q
V
----
G
----
E
L
N
-
E
N
V
R
Q
Q
VI
T
A
D
D
-
V
-
A
H
----
K
-----
E
Q
L
L
Q
W
L
LSNET
Y
T
K
A
I
V
F
TNTRV
S
A
D
R
L
T
G
R
L
IAN---Q
H
K
----
V
F
V
L
HGEKDQK
D
R
K
L
A
I
E
R
L
KQG
A
V
K
I
L
V
ATDVAARGLDVE
G
L
D
L
V
I
NFDMPR------SG
D
------
E
Y
V
H
R
IGRTGRAGAE
G
L
A
I
S
L
I
-C-HG-D-
W
N
L
M
S
S
V
E
R
Y
L
K
QN
F
E
RR
N
I
K
E
L
K
A
A
YQG
P
K
K
LKASGKAAGSK
K
K
K
Q
DRKGAAAKPAAKRKPAARPKAGP
S
A
V
VSADGMAPLKRKKPTAE
107
HHSearch
90.63
36%
-95
- C8 -
2DB3
3
VASA1_DROME
A:
[53-420]
-
Q
P
I
Q
H
--
F
T
-----
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
----
S
K
L
--
L
-
E
D
--
P
H
---------------
E
L
E
L
-
G
R
P
--------
Q
--
V
----------------
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
-
F
E
S
----
Y
---
L
---
K
I
G
I
-
V
----
Y
G
G
T
S
F
R
H
-
Q
-
N
E
-
C
I
T
R
----
G
-
C
H
V
V
I
A
T
P
G
R
L
--
L
D
F
-
V
D
R
T
-
F
I
T
F
E
D
---
T
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
S
E
D
------
M
----
R
R
I
M
T
H
V
----
T
MR-----
P
--
E
--
H
-
Q
T
L
M
F
S
A
T
F
P
E
-
E
I
---
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
----
G
----
G
A
C
-
S
D
V
K
Q
T
I
Y
E
V
N
K
-
Y
-
A
K
----
R
-----
S
K
L
I
E
I
L
S
--
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
----
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
-
D
-
P
E
K
D
-
R
A
I
A
A
D
L
V
K
I
L
-------------------------------------------------------------------------------
115
HHSearch
90.25
37%
-110
- C8 -
2I4I
1
DDX3X_HUMAN
A:
[12-396]
-
P
H
I
E
S
--
F
S
-----
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
----
S
Q
I
--
Y
-
S
D
--
G
P
G
E
A
L
R
A
M
K
E
NGRYGR
R
--
K
-
Q
Y
P
--------
I
--
S
----------------
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-
Y
R
S
----
R
---
V
---
R
P
C
V
-
V
----
Y
G
G
A
D
I
G
Q
-
Q
-
I
R
-
D
L
E
R
----
G
-
C
H
L
L
V
A
T
P
G
R
L
--
V
D
M
-
M
E
R
G
-
K
I
G
L
D
F
---
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
------
I
----
R
R
I
V
E
Q
D
TMPP
K
-------
G
--
V
--
R
-
H
T
M
M
F
S
A
T
F
P
K
-
E
I
---
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
------------
T
S
-
E
N
I
T
Q
K
V
V
W
V
E
E
-
S
-
D
K
----
R
-----
S
F
L
L
D
L
L
N
A
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
----
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
-
N
-
E
R
-
N
-
I
N
I
T
K
D
L
L
D
L
L
V
------------------------------------------------------------------------------
21
PsiBlast_CBE
89.62
37%
-97
- C8 -
2DB3
3
VASA1_DROME
D:
[58-404]
--------
F
T
-----
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
----
S
K
L
--
L
-
E
D
--
P
H
---------------
E
--
L
-
E
L
G
--------
R
PQ
V
----------------
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
-
F
E
S
----
Y
---
L
---
K
I
G
I
-
V
----
Y
G
G
T
S
F
R
H
-
Q
-
N
E
-
C
I
T
R
----
G
-
C
H
V
V
I
A
T
P
G
R
L
--
L
D
F
-
V
D
R
T
-
F
I
T
F
E
D
---
T
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
S
E
D
------
M
----
R
R
I
M
T
H
V
----
T
-------
M
RP
E
--
H
-
Q
T
L
M
F
S
A
T
F
P
E
E
-
I
---
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
----
G
----
G
A
C
-
S
D
V
K
Q
T
I
Y
E
V
N
K
-
Y
-
A
K
----
R
-----
S
K
L
I
E
I
L
--
S
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
----
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
--------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.53
37%
-96
- C8 -
2DB3
3
VASA1_DROME
A:
[58-404]
--------
F
T
-----
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
----
S
K
L
--
L
-
E
D
--
P
H
---------------
E
--
L
-
E
L
G
--------
R
PQ
V
----------------
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
-
F
E
S
----
Y
---
L
---
K
I
G
I
-
V
----
Y
G
G
T
S
F
R
H
-
Q
-
N
E
-
C
I
T
R
----
G
-
C
H
V
V
I
A
T
P
G
R
L
--
L
D
F
-
V
D
R
T
-
F
I
T
F
E
D
---
T
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
S
E
D
------
M
----
R
R
I
M
T
H
V
----
T
-------
M
RP
E
--
H
-
Q
T
L
M
F
S
A
T
F
P
E
E
-
I
---
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
----
G
----
G
A
C
-
S
D
V
K
Q
T
I
Y
E
V
N
K
-
Y
-
A
K
----
R
-----
S
K
L
I
E
I
L
--
S
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
----
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
--------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
89.44
37%
-97
- C8 -
2DB3
3
VASA1_DROME
C:
[58-404]
--------
F
T
-----
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
----
S
K
L
--
L
-
E
D
--
P
H
---------------
E
--
L
-
E
L
G
--------
R
PQ
V
----------------
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
-
F
E
S
----
Y
---
L
---
K
I
G
I
-
V
----
Y
G
G
T
S
F
R
H
-
Q
-
N
E
-
C
I
T
R
----
G
-
C
H
V
V
I
A
T
P
G
R
L
--
L
D
F
-
V
D
R
T
-
F
I
T
F
E
D
---
T
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
S
E
D
------
M
----
R
R
I
M
T
H
V
----
T
-------
M
RP
E
--
H
-
Q
T
L
M
F
S
A
T
F
P
E
E
-
I
---
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
----
G
----
G
A
C
-
S
D
V
K
Q
T
I
Y
E
V
N
K
-
Y
-
A
K
----
R
-----
S
K
L
I
E
I
L
--
S
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
----
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
--------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
89.03
37%
-96
- C8 -
2DB3
3
VASA1_DROME
B:
[58-404]
--------
F
T
-----
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
----
S
K
L
--
L
-
E
D
--
P
H
---------------
E
--
L
-
E
L
G
--------
R
PQ
V
----------------
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
-
F
E
S
----
Y
---
L
---
K
I
G
I
-
V
----
Y
G
G
T
S
F
R
H
-
Q
-
N
E
-
C
I
T
R
----
G
-
C
H
V
V
I
A
T
P
G
R
L
--
L
D
F
-
V
D
R
T
-
F
I
T
F
E
D
---
T
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
S
E
D
------
M
----
R
R
I
M
T
H
V
----
T
-------
M
RP
E
--
H
-
Q
T
L
M
F
S
A
T
F
P
E
E
-
I
---
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
----
G
----
G
A
C
-
S
D
V
K
Q
T
I
Y
E
V
N
K
-
Y
-
A
K
----
R
-----
S
K
L
I
E
I
L
--
S
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
----
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
--------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.73
37%
-110
- C8 -
2I4I
1
DDX3X_HUMAN
A:
[12-387]
-
P
H
I
E
S
--
F
S
-----
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
----
S
Q
I
--
Y
-
S
---
D
G
---------------
P
--
G
-
E
A
L
--------
R
--
A
M
K
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-
Y
R
S
----
R
---
V
---
R
P
C
V
-
V
----
Y
G
G
A
D
I
G
Q
-
Q
-
I
R
-
D
L
E
R
----
G
-
C
H
L
L
V
A
T
P
G
R
L
--
V
D
M
-
M
E
R
G
-
K
I
G
L
D
F
---
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
------
I
R
R
--
I
V
E
Q
D
T
M
----
P
-------
P
--
K
GV
R
-
H
T
M
M
F
S
A
T
F
P
K
E
-
I
---
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
------------
T
S
-
E
N
I
T
Q
K
V
V
W
V
E
E
-
S
-
D
K
----
R
-----
S
F
L
L
D
L
L
N
A
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
----
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
-
N
-
E
R
-
N
-
I
N
I
---------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.94
37%
-94
- C8 -
4PXA
5
DDX3X_HUMAN
A:
[62-437]
-
P
H
I
E
S
--
F
S
-----
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
----
S
Q
I
--
Y
-
S
---
D
G
---------------
P
--
G
-
E
A
L
--------
R
--
A
M
K
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-
Y
R
S
----
R
---
V
---
R
P
C
V
-
V
----
Y
G
G
A
D
I
G
Q
-
Q
-
I
R
-
D
L
E
R
----
G
-
C
H
L
L
V
A
T
P
G
R
L
--
V
D
M
-
M
E
R
G
-
K
I
G
L
D
F
---
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
V
--
M
-
G
-
F
E
P
Q
------
I
R
R
--
I
V
E
Q
D
T
M
----
P
-------
P
--
K
GV
R
-
H
T
M
M
F
S
A
T
F
P
K
E
-
I
---
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
R
V
----
G
----
S
T
S
-
E
N
I
T
Q
K
V
V
W
V
E
E
-
S
-
D
K
----
R
-----
S
F
L
L
D
L
L
N
A
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
----
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
-
N
-
E
R
-
N
-
I
N
I
---------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.16
36%
-107
- C8 -
1HV8
5
H669_METJA
A:
[8-355]
--------
F
N
-----
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
-
D
--
E
--
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
----
E
-
L
--
V
-
N
E
--
N
N
---------------
G
------
I
--------
E
--
A
----------------
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
-
G
N
K
----
N
---
L
---
K
I
A
K
-
I
----
Y
G
G
K
A
I
Y
P
-
Q
-
I
K
-
A
L
-
K
----
N
-
A
N
I
V
V
G
T
P
G
R
I
--
L
D
H
-
I
N
R
G
-
T
L
N
L
K
N
---
V
K
Y
F
I
L
D
E
A
D
E
M
L
-
N
--
M
-
G
-
F
I
K
D
------
V
----
E
K
I
L
N
A
C
----
N
-------
K
--
D
--
K
-
R
I
L
L
F
S
A
T
M
P
R
E
I
L
---
N
-
L
A
K
K
Y
M
G
D
Y
S
F
I
K
--------
A
----
K
I
N
-
A
N
I
E
Q
S
Y
V
E
V
N
E
-
N
-
E
R
----
F
-----
E
A
L
C
R
L
L
K
N
K
E
F
Y
--
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
D
I
---
G
F
K
----
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
------
N
P
E
------
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
-
N
-
R
R
-
E
-
Y
K
K
L
R
Y
I
E
R
---------------------------------------------------------------------------------
5
PsiBlast_PDB
87.01
34%
-93
- C8 -
4D25
4
?
A:
[45-423]
-
P
P
R
P
I
ES
F
E
-----
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
--
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
----
N
M
L
--
L
-
Q
D
-------------------
P
--
K
-
D
L
I
S
E
NG
C
A
Q
P
Q
--
V
----------------
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
-
Y
G
S
----
V
---
L
---
K
V
A
V
-
A
----
Y
G
G
T
A
V
R
H
-
Q
-
G
D
-
N
I
A
R
----
G
-
C
H
I
L
V
A
T
P
G
R
L
--
H
D
F
-
V
E
R
N
-
R
V
S
F
G
S
---
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
--
M
-
G
-
F
M
P
S
------
I
E
K
M
M
L
H
P
T
M
V
E
----
T
-------
T
--
K
--
R
-
Q
T
L
M
F
S
A
T
F
P
-
E
D
I
---
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
----
G
----
G
A
S
-
T
D
V
E
Q
I
F
I
E
V
T
K
-
Y
-
E
K
----
R
-----
N
S
L
K
Q
L
I
E
E
N
D
G
-
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
----
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
D
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
-
D
Q
-
D
-
L
A
L
V
A
D
L
S
K
I
L
R
Q
-----------------------------------------------------------------------------
34
PsiBlast_CBE
86.81
33%
-113
- C8 -
3EWS
1
DD19B_HUMAN
A:
[54-441]
-
P
N
S
P
L
--
Y
S
V
KSFE
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
----
S
Q
V
--
E
-
P
A
--
N
K
---------------------
Y
P
--------
Q
--
C
----------------
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-
K
F
-----
Y
---
P
---
E
L
K
L
-
A
---------
Y
A
V
-
R
-
G
N
-
K
L
E
R
GQKI
S
-
E
Q
I
V
I
G
T
P
G
T
V
--
L
D
W
---
C
S
-
K
L
K
F
I
D
PKK
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
-
H
Q
D
Q
------
S
----
I
R
I
Q
R
M
L
----
P
-------
R
--
N
--
C
-
Q
M
L
L
F
S
A
T
F
E
D
S
-
V
---
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
----
E
----
E
T
L
-
D
T
I
K
Q
Y
Y
V
L
C
S
S
-
R
-
D
E
----
K
-----
F
Q
A
L
C
N
L
Y
G
A
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
----
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
D
GNPD
N
E
T
Y
L
H
R
I
G
R
----
G
K
R
G
L
A
V
N
M
V
D
S
-
K
H
-
S
-
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
T
D
D
L
-------------------------------------------------------------------
39
PsiBlast_CBE
86.37
31%
-105
- C8 -
4CT4
3
DDX6_HUMAN
B:
[7-362]
--------
F
E
-----
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
--
S
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
----
E
R
L
--------
D
L
---------------
K
--
K
-
D
N
I
--------
Q
--
A
----------------
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
-
K
H
M
----
G
G--
A
---
K
V
M
A
-
T
----
T
G
G
T
N
L
R
D
-
D
-
I
M
-
R
L
D
D
----
T
-
V
H
V
V
I
A
T
P
G
R
I
--
L
D
L
-
I
K
K
G
-
V
A
K
V
D
H
---
V
Q
M
I
V
L
D
E
A
D
K
L
L
-
S
--
Q
-
D
-
F
V
Q
I
------
M
----
E
D
I
I
L
T
L
----
P
-------
K
--
N
--
R
-
Q
I
L
L
Y
S
A
T
F
P
-
L
S
V
---
Q
K
F
M
N
S
H
L
Q
K
P
--
Y
E
I
N
L
M
----
E
----
E
L
T
-
L
K
G
V
T
Q
Y
Y
A
Y
V
T
-
E
-
R
Q
----
K
-----
V
H
C
L
N
T
L
F
S
R
L
Q
I
N
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
---
G
Y
S
----
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
E
------
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
-
T
-
Y
D
-
D
-
R
F
N
L
K
S
I
E
E
Q
L
-------------------------------------------------------------------------------
24
PsiBlast_CBE
86.03
39%
-98
- C8 -
4KBG
4
?
B:
[3-365]
--------
F
K
-----
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
----
E
R
L
--
A
-
P
S
--
Q
E
---------------
R
--
G
-
R
K
P
--------
R
--
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
---
P
----
H
---
L
---
K
V
V
A
-
V
----
Y
G
G
T
G
Y
G
K
-
Q
-
K
E
-
A
L
L
R
----
G
-
A
D
A
V
V
A
T
P
G
R
A
--
L
D
Y
-
L
R
Q
G
-
V
L
D
L
S
R
---
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
------
V
----
E
A
L
L
S
A
T
----
P
-------
P
--
S
--
R
-
Q
T
L
L
F
S
A
T
L
P
S
W
A
-----
K
R
L
A
E
R
Y
M
K
N
P
V
L
-
I
N
V
I
----
K
----
D
E
P
-
V
T
Y
E
E
E
A
V
P
A
P
--
V
-
R
G
----
R
-----
L
E
V
L
S
D
L
L
Y
V
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
----
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
E
------
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
-
G
-
P
R
-
E
-
R
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
R
V
N
-----------------------------------------------------------------------
15
PsiBlast_PDB
85.90
33%
-105
- C8 -
3PEY
11
DBP5_YEAST
A:
[7-369]
--------
F
D
-----
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
----
T
R
V
--
N
-
P
E
--
D
---------------------
A
S
P
--------
Q
--
A
----------------
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
-
K
F
T
----
K
---
I
---
T
S
Q
L
-
I
----
V
P
D
S
F
E
K
N
-
K
------
Q
I
----
N
-
A
Q
V
I
V
G
T
P
G
T
V
--
L
D
L
-
M
R
R
K
-
L
M
Q
L
Q
K
---
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
-
L
G
D
Q
------
C
----
I
R
V
K
R
F
L
----
P
-------
K
--
D
--
T
-
Q
L
V
L
F
S
A
T
F
A
D
A
-
V
---
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
-
Q
T
----
N
----
E
V
N
V
D
A
I
K
Q
L
Y
M
D
C
K
N
-
E
-
A
D
----
K
-----
F
D
V
L
T
E
L
Y
G
L
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
----
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
------
L
A
N
GQAD
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
-
H
-
D
K
-
N
S
F
N
I
L
S
A
I
Q
K
Y
F
-------------------------------------------------------------------------------
6
PsiBlast_PDB
85.74
34%
-92
- C8 -
4D26
4
?
A:
[45-423]
-
P
P
R
P
I
ES
F
E
-----
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
--
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
----
N
M
L
--
L
-
Q
D
-------------------
P
--
K
-
D
L
I
S
E
NG
C
A
Q
P
Q
--
V
----------------
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
-
Y
G
S
----
V
---
L
---
K
V
A
V
-
A
----
Y
G
G
T
A
V
R
H
-
Q
-
G
D
-
N
I
A
R
----
G
-
C
H
I
L
V
A
T
P
G
R
L
--
H
D
F
-
V
E
R
N
-
R
V
S
F
G
S
---
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
--
M
-
G
-
F
M
P
S
------
I
E
K
M
M
L
H
P
T
M
V
E
----
T
-------
T
--
K
--
R
-
Q
T
L
M
F
S
A
T
F
P
-
E
D
I
---
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
----
G
----
G
A
S
-
T
D
V
E
Q
I
F
I
E
V
T
K
-
Y
-
E
K
----
R
-----
N
S
L
K
Q
L
I
E
E
N
D
G
-
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
----
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
D
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
-
D
Q
-
D
-
L
A
L
V
A
D
L
S
K
I
L
R
Q
-----------------------------------------------------------------------------
12
PsiBlast_PDB
85.56
33%
-105
- C8 -
3PEW
9
DBP5_YEAST
A:
[7-369]
--------
F
D
-----
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
----
T
R
V
--
N
-
P
E
--
D
---------------------
A
S
P
--------
Q
--
A
----------------
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
-
K
F
T
----
K
---
I
---
T
S
Q
L
-
I
----
V
P
D
S
F
E
K
N
-
K
------
Q
I
----
N
-
A
Q
V
I
V
G
T
P
G
T
V
--
L
D
L
-
M
R
R
K
-
L
M
Q
L
Q
K
---
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
-
L
G
D
Q
------
C
----
I
R
V
K
R
F
L
----
P
-------
K
--
D
--
T
-
Q
L
V
L
F
S
A
T
F
A
D
A
-
V
---
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
-
Q
T
----
N
----
E
V
N
V
D
A
I
K
Q
L
Y
M
D
C
K
N
-
E
-
A
D
----
K
-----
F
D
V
L
T
E
L
Y
G
V
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
----
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
------
L
A
N
GQAD
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
-
H
-
D
K
-
N
S
F
N
I
L
S
A
I
Q
K
Y
F
-------------------------------------------------------------------------------
25
PsiBlast_CBE
85.42
39%
-104
- C8 -
4KBF
1
?
B:
[3-365]
--------
F
K
-----
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
----
E
R
L
--
A
-
P
S
--
Q
E
---------------
R
--
G
-
R
K
P
--------
R
--
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
---
P
----
H
---
L
---
K
V
V
A
-
V
----
Y
G
G
T
G
Y
G
K
-
Q
-
K
E
-
A
L
L
R
----
G
-
A
D
A
V
V
A
T
P
G
R
A
--
L
D
Y
-
L
R
Q
G
-
V
L
D
L
S
R
---
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
------
V
----
E
A
L
L
S
A
T
----
P
-------
P
--
S
--
R
-
Q
T
L
L
F
S
A
T
L
P
S
W
A
-----
K
R
L
A
E
R
Y
M
K
N
P
V
L
-
I
N
V
I
----
K
----
D
E
P
-
V
T
Y
E
E
E
A
V
P
A
P
--
V
-
R
G
----
R
-----
L
E
V
L
S
D
L
L
Y
V
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
----
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
E
------
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
-
G
-
P
R
-
E
-
R
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
R
V
N
-----------------------------------------------------------------------
118
HHSearch
85.13
35%
-104
- C8 -
1HV8
5
H669_METJA
A:
[6-362]
----
M
N
--
F
N
-----
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
--
N
--
D
E-
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
----
E
L
V
--
N
-
E
N
------------------------
N
G
I
--------
E
--
A
----------------
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
-
G
N
K
----
N
---
L
---
K
I
A
K
-
I
----
Y
G
G
K
A
I
Y
P
---
Q
I
-
K
A
L
K
----
N
-
A
N
I
V
V
G
T
P
G
R
I
--
L
D
H
-
I
N
R
G
-
T
L
N
L
K
N
---
V
K
Y
F
I
L
D
E
A
D
E
M
L
-
N
--
M
-
G
-
F
I
K
D
------
V
----
E
K
I
L
N
A
C
----
N
-------
K
--
D
--
K
-
R
I
L
L
F
S
A
T
M
P
R
E
I
----
L
N
L
A
K
K
Y
M
G
D
Y
S
F
I
K
A
K
------------
I
N
-
A
N
I
E
Q
S
Y
V
E
V
N
E
-
N
-
E
R
----
F
-----
E
A
L
C
R
L
L
K
--
N
K
E
F
Y
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
D
I
---
G
F
K
----
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
------
N
P
E
------
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
-
N
-
R
R
-
E
-
Y
K
K
L
R
Y
I
E
R
A
M
K
L
K
I
K
--------------------------------------------------------------------------
20
PsiBlast_PDB
84.80
32%
-92
- C8 -
2J0S
3
IF4A3_HUMAN
A:
[36-400]
---
T
P
T
--
F
D
-----
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
----
Q
C
L
--------
D
I
---------------
Q
--
V
-
R
E
T
--------
Q
--
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-
D
Y
M
----
N
---
V
---
Q
C
H
A
-
C
----
I
G
G
T
N
V
G
E
-
D
-
I
R
-
K
L
D
Y
----
G
-
Q
H
V
V
A
G
T
P
G
R
V
--
F
D
M
-
I
R
R
R
-
S
L
R
T
R
A
---
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
-
F
K
E
Q
------
I
----
Y
D
V
Y
R
Y
L
----
P
-------
P
--
A
--
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
-----
I
L
V
K
R
----
D
----
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
W
----
K
-----
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
----
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
-
N
D
-
D
-
I
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
--------------------------------------------------------------------------
17
PsiBlast_PDB
84.78
32%
-91
- C8 -
2HYI
3
IF4A3_HUMAN
C:
[37-401]
---
T
P
T
--
F
D
-----
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
----
Q
C
L
--------
D
I
---------------
Q
--
V
-
R
E
T
--------
Q
--
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-
D
Y
M
----
N
---
V
---
Q
C
H
A
-
C
----
I
G
G
T
N
V
G
E
-
D
-
I
R
-
K
L
D
Y
----
G
-
Q
H
V
V
A
G
T
P
G
R
V
--
F
D
M
-
I
R
R
R
-
S
L
R
T
R
A
---
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
-
F
K
E
Q
------
I
----
Y
D
V
Y
R
Y
L
----
P
-------
P
--
A
--
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
-----
I
L
V
K
R
----
D
----
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
W
----
K
-----
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
----
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
-
N
D
-
D
-
I
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
--------------------------------------------------------------------------
14
PsiBlast_PDB
84.42
33%
-108
- C8 -
3RRN
2
DBP5_YEAST
A:
[7-369]
--------
F
D
-----
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
----
T
R
V
--
N
-
P
E
--
D
---------------------
A
S
P
--------
Q
--
A
----------------
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
-
K
F
T
----
K
---
I
---
T
S
Q
L
-
I
----
V
P
D
S
F
E
K
N
-
K
------
Q
I
----
N
-
A
Q
V
I
V
G
T
P
G
T
V
--
L
D
L
-
M
R
R
K
-
L
M
Q
L
Q
K
---
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
-
L
G
D
Q
------
C
----
I
R
V
K
R
F
L
----
P
-------
K
--
D
--
T
-
Q
L
V
L
F
S
A
T
F
A
D
A
-
V
---
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
-
Q
--------------
D
A
I
K
Q
L
Y
M
D
C
K
N
-
E
-
A
D
----
K
-----
F
D
V
L
T
E
L
Y
G
V
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
----
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
------
L
A
N
GQAD
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
-
H
-
D
K
-
N
S
F
N
I
L
S
A
I
Q
K
Y
F
-------------------------------------------------------------------------------
11
PsiBlast_PDB
84.42
33%
-106
- C8 -
4BRW
2
DHH1_YEAST
A:
[3-345]
--------
F
E
-----
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
--
T
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
----
E
K
V
---------
K
---------------
P
--
K
L
N
K
I
--------
Q
--
A
----------------
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
-
K
H
C
----
G
---
I
---
S
C
M
V
-
T
----
T
G
G
T
N
L
R
D
-
D
-
I
L
-
R
L
N
E
----
T
-
V
H
I
L
V
G
T
P
G
R
V
--
L
D
L
-
A
S
R
K
-
V
A
D
L
S
D
---
C
S
L
F
I
M
D
E
A
D
K
M
L
-
S
--
R
-
D
-
F
K
T
I
------
I
----
E
Q
I
L
S
F
L
----
P
-------
P
--
T
--
H
-
Q
S
L
L
F
S
A
T
F
P
-
L
T
V
---
D
E
F
M
D
K
H
L
H
K
P
Y
--
E
I
N
L
M
----
E
----
E
L
T
-
L
K
G
I
T
Q
Y
Y
A
F
V
E
-
E
-
R
Q
----
K
-----
L
H
C
L
N
T
L
F
S
K
L
Q
I
N
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
---
G
Y
S
----
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
E
------
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
------
N
-
W
N
----------------------------------------------------------------------------------------
114
HHSearch
84.23
32%
-90
- C8 -
3I5X
3
MS116_YEAST
A:
[78-458]
-----------------
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
--
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
----
Q
H
L
--
I
-
N
T
--
K
F
D--------------
S
--
Q
-
Y
M
V
--------
K
--
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-
D
M
N
Y---
G
---
L
KKY
A
C
V
S
-
L
----
V
G
G
T
D
F
R
A
-
A
M
N
K
-
M
N
K
L
----
R
-
P
N
I
V
I
A
T
P
G
R
L
--
I
D
V
-
L
E
K
Y
S
N
K
F
F
R
F
---
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
------
L
----
E
T
I
S
G
I
L
----
N
E
K
NSKSA
D
--
N
--
I
-
K
T
L
L
F
S
A
T
L
D
D
-
K
V
---
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
DKNE
P
----
E
A
H
-
E
R
I
D
Q
S
V
V
I
S
E
K
-
F
A
N
S
I
F
A
A
V
-----
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
FKK
D
L
P
----
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
----------------------------------------------------------------------------------
7
PsiBlast_PDB
84.22
39%
-94
- C8 -
4KBF
3
?
A:
[3-365]
--------
F
K
-----
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
----
E
R
L
--
A
-
P
S
--
Q
E
---------------
R
--
G
-
R
K
P
--------
R
--
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
---
P
----
H
---
L
---
K
V
V
A
-
V
----
Y
G
G
T
G
Y
G
K
-
Q
-
K
E
-
A
L
L
R
----
G
-
A
D
A
V
V
A
T
P
G
R
A
--
L
D
Y
-
L
R
Q
G
-
V
L
D
L
S
R
---
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
------
V
----
E
A
L
L
S
A
T
----
P
-------
P
--
S
--
R
-
Q
T
L
L
F
S
A
T
L
P
S
W
A
-----
K
R
L
A
E
R
Y
M
K
N
P
V
L
-
I
N
V
I
----
K
----
D
E
P
-
V
T
Y
E
E
E
A
V
P
A
P
--
V
-
R
G
----
R
-----
L
E
V
L
S
D
L
L
Y
V
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
----
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
E
------
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
-
G
-
P
R
-
E
-
R
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
R
V
N
-----------------------------------------------------------------------
45
PsiBlast_CBE
84.11
31%
-104
- C8 -
1XTI
4
DX39B_HUMAN
A:
[10-373]
--------
F
R
-----
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
--
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
----
Q
Q
L
--------
E
P
---------------
V
--
T
-
G
Q
V
--------
S
--
V
----------------
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
-
K
Y
M
P---
N
---
V
---
K
V
A
V
-
F
----
F
G
G
L
S
I
K
K
-
D
-
E
E
-
V
L
K
K
----
N
C
P
H
I
V
V
G
T
P
G
R
I
--
L
A
L
-
A
R
N
K
-
S
L
N
L
K
H
---
I
K
H
F
I
L
D
E
C
D
K
M
L
-
E
Q-
L
-
D
-
M
R
R
D
------
V
----
Q
E
I
F
R
M
T
----
P
-------
H
--
E
--
K
-
Q
V
M
M
F
S
A
T
L
S
K
E
-
I
---
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
D
D
E
----
T
----
K
L
T
-
L
H
G
L
Q
Q
Y
Y
V
K
L
K
-
D
-
N
E
----
K
-----
N
R
K
L
F
D
L
L
D
V
L
E
F
N
Q
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
E
Q
---
N
F
P
----
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
E
------
D
S
D
------
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
-
S
D
E
N
-
D
-
A
K
I
L
N
D
V
Q
D
R
F
E
V
N
----------------------------------------------------------------------------
41
PsiBlast_CBE
84.02
33%
-117
- C8 -
2VSX
1
IF4A_YEAST
A:
[24-384]
--------
F
D
-----
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
----
Q
R
I
--------
D
T
---------------
S
--
V
-
K
A
P
--------
Q
--
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
-
F
H
M
----
D
---
I
---
K
V
H
A
-
C
----
I
G
--------------
L
R
----
D
-
A
Q
I
V
V
G
T
P
G
R
V
--
F
D
N
-
I
Q
R
R
-
R
F
R
T
D
K
---
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
-
F
K
E
Q
------
I
----
Y
Q
I
F
T
L
L
----
P
-------
P
--
T
--
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
----
E
V
T
T
K
F
M
R
N
P
-
V
R
I
L
V
K
K
----
D
----
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
E
-
E
-
E
Y
----
K
-----
Y
E
C
L
T
D
L
Y
D
S
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
----
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
------
N
Y
I
H
R
I
G
------
R
K
G
V
A
I
N
F
V
-
T
-
N
E
-
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
--------------------------------------------------------------------------
40
PsiBlast_CBE
84.00
33%
-117
- C8 -
2VSX
1
IF4A_YEAST
B:
[24-384]
--------
F
D
-----
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
----
Q
R
I
--------
D
T
---------------
S
--
V
-
K
A
P
--------
Q
--
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
-
F
H
M
----
D
---
I
---
K
V
H
A
-
C
----
I
G
--------------
L
R
----
D
-
A
Q
I
V
V
G
T
P
G
R
V
--
F
D
N
-
I
Q
R
R
-
R
F
R
T
D
K
---
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
-
F
K
E
Q
------
I
----
Y
Q
I
F
T
L
L
----
P
-------
P
--
T
--
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
----
E
V
T
T
K
F
M
R
N
P
-
V
R
I
L
V
K
K
----
D
----
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
E
-
E
-
E
Y
----
K
-----
Y
E
C
L
T
D
L
Y
D
S
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
----
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
------
N
Y
I
H
R
I
G
------
R
K
G
V
A
I
N
F
V
-
T
-
N
E
-
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
--------------------------------------------------------------------------
119
HHSearch
83.71
32%
-89
- C8 -
3SQW
3
MS116_YEAST
A:
[24-407]
---------
E
-----
E
G
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
--
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
----
Q
H
L
--
I
-
N
T
--
K
F
---------------
D
S-
Q
-
Y
M
V
--------
K
--
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-
D
M
N
YGLK
K
---
Y
---
A
C
V
S
-
L
----
V
G
G
T
D
F
R
A
A
M
-
N
K
-
M
N
K
L
----
R
-
P
N
I
V
I
A
T
P
G
R
L
--
I
D
V
-
L
E
K
Y
S
N
K
F
F
R
F
---
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
------
L
----
E
T
I
S
G
I
L
----
N
E
K
NSKSA
D
--
N
--
I
-
K
T
L
L
F
S
A
T
L
D
D
-
K
V
---
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
DKNE
P
----
E
A
H
-
E
R
I
D
Q
S
V
V
I
S
E
K
F
A
-
N
S
I
F
A
A
V
-----
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
FKK
D
L
P
----
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
----------------------------------------------------------------------------------
33
PsiBlast_CBE
83.67
33%
-97
- C8 -
3G0H
4
DD19B_HUMAN
A:
[33-416]
-
P
N
S
P
L
--
Y
S
VKSFE
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
----
S
Q
V
--
E
-
P
A
--
N
K
---------------------
Y
P
--------
Q
--
C
----------------
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-
K
F
-----
Y
---
P
---
E
L
K
L
-
A
---------
Y
A
V
-
R
-
G
N
-
K
L
E
R
GQKI
S
-
E
Q
I
V
I
G
T
P
G
T
V
--
L
D
W
---
C
S
-
K
L
K
F
I
D
PKK
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
-
H
Q
D
Q
------
S
----
I
R
I
Q
R
M
L
----
P
-------
R
--
N
--
C
-
Q
M
L
L
F
S
A
T
F
E
D
S
-
V
---
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
----
E
----
E
T
L
-
D
T
I
K
Q
Y
Y
V
L
C
S
S
-
R
-
D
E
----
K
-----
F
Q
A
L
C
N
L
Y
G
A
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
----
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
D
GNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
-
K
H
-
S
-
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
-----------------------------------------------------------------------
43
PsiBlast_CBE
83.63
33%
-118
- C8 -
2VSO
1
IF4A_YEAST
A:
[24-384]
--------
F
D
-----
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
----
Q
R
I
--------
D
T
---------------
S
--
V
-
K
A
P
--------
Q
--
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
-
F
H
M
----
D
---
I
---
K
V
H
A
-
C
----
I
G
--------------
L
R
----
D
-
A
Q
I
V
V
G
T
P
G
R
V
--
F
D
N
-
I
Q
R
R
-
R
F
R
T
D
K
---
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
-
F
K
E
Q
------
I
----
Y
Q
I
F
T
L
L
----
P
-------
P
--
T
--
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
----
E
V
T
T
K
F
M
R
N
P
-
V
R
I
L
V
K
K
----
D
----
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
E
-
E
-
E
Y
----
K
-----
Y
E
C
L
T
D
L
Y
D
S
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
----
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
------
N
Y
I
H
R
I
G
------
R
K
G
V
A
I
N
F
V
-
T
-
N
E
-
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
--------------------------------------------------------------------------
42
PsiBlast_CBE
83.61
33%
-118
- C8 -
2VSO
1
IF4A_YEAST
B:
[24-384]
--------
F
D
-----
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
----
Q
R
I
--------
D
T
---------------
S
--
V
-
K
A
P
--------
Q
--
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
-
F
H
M
----
D
---
I
---
K
V
H
A
-
C
----
I
G
--------------
L
R
----
D
-
A
Q
I
V
V
G
T
P
G
R
V
--
F
D
N
-
I
Q
R
R
-
R
F
R
T
D
K
---
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
-
F
K
E
Q
------
I
----
Y
Q
I
F
T
L
L
----
P
-------
P
--
T
--
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
----
E
V
T
T
K
F
M
R
N
P
-
V
R
I
L
V
K
K
----
D
----
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
E
-
E
-
E
Y
----
K
-----
Y
E
C
L
T
D
L
Y
D
S
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
----
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
------
N
Y
I
H
R
I
G
------
R
K
G
V
A
I
N
F
V
-
T
-
N
E
-
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
--------------------------------------------------------------------------
35
PsiBlast_CBE
83.42
33%
-101
- C8 -
3FHT
6
DD19B_HUMAN
B:
[17-400]
-
P
N
S
P
L
--
Y
S
VKSFE
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
----
S
Q
V
--
E
-
P
A
--
N
K
---------------------
Y
P
--------
Q
--
C
----------------
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-
K
F
-----
Y
---
P
---
E
L
K
L
-
A
---------
Y
A
V
-
R
-
G
N
-----KI--
S
-
E
Q
I
V
I
G
T
P
G
T
V
--
L
D
W
---
C
S
-
K
L
K
F
I
D
PKK
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
-
H
Q
D
Q
------
S
----
I
R
I
Q
R
M
L
----
P
-------
R
--
N
--
C
-
Q
M
L
L
F
S
A
T
F
E
D
S
-
V
---
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
----
E
----
E
T
L
-
D
T
I
K
Q
Y
Y
V
L
C
S
S
-
R
-
D
E
----
K
-----
F
Q
A
L
C
N
L
Y
G
A
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
----
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
D
GNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
-
K
H
-
S
-
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
-----------------------------------------------------------------------
36
PsiBlast_CBE
83.10
33%
-99
- C8 -
3FHT
4
DD19B_HUMAN
A:
[17-399]
-
P
N
S
P
L
--
Y
S
VKSFE
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
----
S
Q
V
--
E
-
P
A
--
N
K
---------------------
Y
P
--------
Q
--
C
----------------
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-
K
F
-----
Y
---
P
---
E
L
K
L
-
A
---------
Y
A
V
-
R
-
G
N
-
K
L
E
R
GQKI
S
-
E
Q
I
V
I
G
T
P
G
T
V
--
L
D
W
---
C
S
-
K
L
K
F
I
D
PKK
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
-
H
Q
D
Q
------
S
----
I
R
I
Q
R
M
L
----
P
-------
R
--
N
--
C
-
Q
M
L
L
F
S
A
T
F
E
D
S
-
V
---
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
----
E
----
E
T
L
-
D
T
I
K
Q
Y
Y
V
L
C
S
S
-
R
-
D
E
----
K
-----
F
Q
A
L
C
N
L
Y
G
A
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
----
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
D
GNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
-
K
H
-
S
-
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
------------------------------------------------------------------------
50
PsiBlast_CBE
82.13
31%
-86
- C8 -
3I5X
3
MS116_YEAST
A:
[79-458]
------------------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
----
Q
H
L
--
I
N
T
K
--
F
D
---------------
S
--
Q
-
Y
M
V
--------
K
--
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-
D
M
N
----
Y
GLK
K
---
Y
A
C
V
S
L
----
V
G
G
T
D
F
R
A
-
A
-
M
N
-
K
M
N
K
L
---
R
-
P
N
I
V
I
A
T
P
G
R
L
--
I
D
V
L
E
K
Y
S
-
N
K
F
F
R
F
---
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
L
E
T
I
S
G
I
----
L
N
E
K
N
S
K
----
S
-------
A
--
D
--
N
I
K
T
L
L
F
S
A
T
L
D
D
K
-
V
---
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
KNEP
E
A
H
-
E
R
I
D
Q
S
V
V
I
S
E
K
-
F
-
A
N
----
S
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
-
V
K
F
T
S
F
L
C
S
I
L
K
N
---
E
F
K
KD
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
----------------------------------------------------------------------------------
47
PsiBlast_CBE
81.91
31%
-85
- C8 -
3I62
4
MS116_YEAST
A:
[79-458]
------------------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
----
Q
H
L
--
I
N
T
K
--
F
D
---------------
S
--
Q
-
Y
M
V
--------
K
--
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-
D
M
N
----
Y
GLK
K
---
Y
A
C
V
S
L
----
V
G
G
T
D
F
R
A
-
A
-
M
N
-
K
M
N
K
L
---
R
-
P
N
I
V
I
A
T
P
G
R
L
--
I
D
V
L
E
K
Y
S
-
N
K
F
F
R
F
---
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
L
E
T
I
S
G
I
----
L
N
E
K
N
S
K
----
S
-------
A
--
D
--
N
I
K
T
L
L
F
S
A
T
L
D
D
K
-
V
---
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
KNEP
E
A
H
-
E
R
I
D
Q
S
V
V
I
S
E
K
-
F
-
A
N
----
S
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
-
V
K
F
T
S
F
L
C
S
I
L
K
N
---
E
F
K
KD
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
----------------------------------------------------------------------------------
116
HHSearch
81.89
34%
-97
- C8 -
3PEY
11
DBP5_YEAST
A:
[4-357]
---
A
K
S
--
F
D
-----
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
----
T
R
V
--
N
-
P
E
--
D
---------------------
A
S
P
--------
Q
--
A
----------------
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
-
K
F
T
----
K
---
I
---
T
S
Q
L
-
I
----
V
P
D
S
-----
F
-
E
K
-
N
K
Q
I
----
N
-
A
Q
V
I
V
G
T
P
G
T
V
--
L
D
L
-
M
R
R
K
-
L
M
Q
L
Q
K
---
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
-
Q
G
L
G
D
Q
------
C
----
I
R
V
K
R
F
L
----
P
-------
K
--
D
--
T
-
Q
L
V
L
F
S
A
T
F
A
D
A
-
V
---
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
----
E
----
V
N
V
-
D
A
I
K
Q
L
Y
M
D
C
K
N
-
E
-
A
D
----
K
-----
F
D
V
L
T
E
L
Y
G
L
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
----
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
A
------
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
-
H
-
D
K
-
N
-------------------------------------------------------------------------------------------
48
PsiBlast_CBE
81.77
31%
-86
- C8 -
3I61
4
MS116_YEAST
A:
[79-458]
------------------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
----
Q
H
L
--
I
N
T
K
--
F
D
---------------
S
--
Q
-
Y
M
V
--------
K
--
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-
D
M
N
----
Y
GLK
K
---
Y
A
C
V
S
L
----
V
G
G
T
D
F
R
A
-
A
-
M
N
-
K
M
N
K
L
---
R
-
P
N
I
V
I
A
T
P
G
R
L
--
I
D
V
L
E
K
Y
S
-
N
K
F
F
R
F
---
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
L
E
T
I
S
G
I
----
L
N
E
K
N
S
K
----
S
-------
A
--
D
--
N
I
K
T
L
L
F
S
A
T
L
D
D
K
-
V
---
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
KNEP
E
A
H
-
E
R
I
D
Q
S
V
V
I
S
E
K
-
F
-
A
N
----
S
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
-
V
K
F
T
S
F
L
C
S
I
L
K
N
---
E
F
K
KD
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
----------------------------------------------------------------------------------
51
PsiBlast_CBE
81.73
31%
-84
- C8 -
3SQX
3
MS116_YEAST
A:
[28-407]
------------------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
----
Q
H
L
--
I
N
T
K
--
F
D
---------------
S
--
Q
-
Y
M
V
--------
K
--
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-
D
M
N
----
Y
GLK
K
---
Y
A
C
V
S
L
----
V
G
G
T
D
F
R
A
-
A
-
M
N
-
K
M
N
K
L
---
R
-
P
N
I
V
I
A
T
P
G
R
L
--
I
D
V
L
E
K
Y
S
-
N
K
F
F
R
F
---
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
L
E
T
I
S
G
I
----
L
N
E
K
N
S
K
----
S
-------
A
--
D
--
N
I
K
T
L
L
F
S
A
T
L
D
D
K
-
V
---
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
KNEP
E
A
H
-
E
R
I
D
Q
S
V
V
I
S
E
K
-
F
-
A
N
----
S
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
-
V
K
F
T
S
F
L
C
S
I
L
K
N
---
E
F
K
KD
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
----------------------------------------------------------------------------------
111
HHSearch
81.47
33%
-95
- C8 -
3FHT
4
DD19B_HUMAN
A:
[22-397]
-
Y
S
V
K
S
--
F
E
-----
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
----
S
Q
V
--
E
-
P
A
--
N
---------------------
K
Y
P
--------
Q
--
C
----------------
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-
K
F
Y
----
P
E--
L
---
K
L
A
Y
-
A
----
V
R
G
N
---
K
-
L
-
E
R
-
G
Q
K
I
----
S
-
E
Q
I
V
I
G
T
P
G
T
V
--
L
D
W
-
C
S
K
L
K
F
I
D
P
K
K
---
I
K
V
F
V
L
D
E
A
D
V
M
I
-
A
--
T
Q
G
-
H
Q
D
Q
------
S
----
I
R
I
Q
R
M
L
----
P
-------
R
--
N
--
C
-
Q
M
L
L
F
S
A
T
F
E
D
-
S
V
---
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
----
E
----
E
T
L
-
D
T
I
K
Q
Y
Y
V
L
C
S
S
-
R
D
E
K
----
F
-----
Q
A
L
C
N
L
Y
G
-
A
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
----
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
DKDGNP
D
N
E
------
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
-
D
-
S
K
-
H
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
--------------------------------------------------------------------------
49
PsiBlast_CBE
81.40
31%
-84
- C8 -
3I5Y
3
MS116_YEAST
A:
[79-458]
------------------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
----
Q
H
L
--
I
N
T
K
--
F
D
---------------
S
--
Q
-
Y
M
V
--------
K
--
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-
D
M
N
----
Y
GLK
K
---
Y
A
C
V
S
L
----
V
G
G
T
D
F
R
A
-
A
-
M
N
-
K
M
N
K
L
---
R
-
P
N
I
V
I
A
T
P
G
R
L
--
I
D
V
L
E
K
Y
S
-
N
K
F
F
R
F
---
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
L
E
T
I
S
G
I
----
L
N
E
K
N
S
K
----
S
-------
A
--
D
--
N
I
K
T
L
L
F
S
A
T
L
D
D
K
-
V
---
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
KNEP
E
A
H
-
E
R
I
D
Q
S
V
V
I
S
E
K
-
F
-
A
N
----
S
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
-
V
K
F
T
S
F
L
C
S
I
L
K
N
---
E
F
K
KD
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
----------------------------------------------------------------------------------
46
PsiBlast_CBE
81.37
31%
-85
- C8 -
3SQW
3
MS116_YEAST
A:
[28-407]
------------------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
----
Q
H
L
--
I
N
T
K
--
F
D
---------------
S
--
Q
-
Y
M
V
--------
K
--
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-
D
M
N
----
Y
GLK
K
---
Y
A
C
V
S
L
----
V
G
G
T
D
F
R
A
-
A
-
M
N
-
K
M
N
K
L
---
R
-
P
N
I
V
I
A
T
P
G
R
L
--
I
D
V
L
E
K
Y
S
-
N
K
F
F
R
F
---
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
L
E
T
I
S
G
I
----
L
N
E
K
N
S
K
----
S
-------
A
--
D
--
N
I
K
T
L
L
F
S
A
T
L
D
D
K
-
V
---
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
KNEP
E
A
H
-
E
R
I
D
Q
S
V
V
I
S
E
K
-
F
-
A
N
----
S
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
-
V
K
F
T
S
F
L
C
S
I
L
K
N
---
E
F
K
KD
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
----------------------------------------------------------------------------------
113
HHSearch
80.88
31%
-105
- C8 -
1XTI
4
DX39B_HUMAN
A:
[9-357]
-----
G
--
F
R
-----
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
--
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
----
Q
Q
L
--
E
-
P
V
--
T
---------------------
G
Q
V
--------
S
--
V
----------------
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
-
K
Y
M
P---
N
---
V
---
K
V
A
V
-
F
----
F
G
G
L
S
I
K
K
-
D
-
E
E
V
L
K
K
N
----
C
-
P
H
I
V
V
G
T
P
G
R
I
--
L
A
L
-
A
R
N
K
-
S
L
N
L
K
H
---
I
K
H
F
I
L
D
E
C
D
K
M
L
-
E
--
Q
L
D
-
M
R
R
D
------
V
----
Q
E
I
F
R
M
T
----
P
-------
H
--
E
--
K
-
Q
V
M
M
F
S
A
T
L
S
K
E
-
I
---
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
D
D
E
T---
K
----
L
T
L
-
H
G
L
Q
Q
Y
Y
V
K
L
K
D
-
N
-
E
K
----
N
-----
R
K
L
F
D
L
L
D
V
-
L
E
F
N
Q
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
E
Q
---
N
F
P
----
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
E
------
D
S
D
------
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
-
S
-
D
E
---------------------------------------------------------------------------------------------
53
PsiBlast_CBE
68.56
46%
-119
- C8 -
2GXS
4
?
B:
[3-184]
--------
F
K
-----
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
----
E
R
L
--
A
-
P
S
--
Q
E
---------------
R
--
G
-
R
K
P
--------
R
--
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-
P
------
H
---
L
---
K
V
V
A
-
V
----
Y
G
G
T
G
Y
G
K
-
Q
-
K
E
-
A
L
L
R
----
G
-
A
D
A
V
V
A
T
P
G
R
A
--
L
D
Y
-
L
R
Q
G
-
V
L
D
L
S
R
---
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
------
V
----
E
A
L
L
S
A
T
----
P
-------
P
--
S
--
R
-
Q
T
L
L
F
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
68.41
41%
-116
- C8 -
3BER
4
DDX47_HUMAN
A:
[45-228]
--------
F
K
-----
D
L
G
V
T
D
V
L
C
E
A
C
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
P
L
A
L
--
Q
--
G
--
R
D
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
I
L
----
N
A
L
--
L
-----
E
T
---------------
P
--
Q
-
R
L
F
-----------
A
----------------
L
V
L
T
P
T
R
E
L
A
F
Q
I
S
E
Q
F
E
A
L
G
-
S
S
I
----
G
---
V
---
Q
S
A
V
-
I
----
V
G
G
I
D
S
M
S
-
Q
-
S
L
-
A
L
A
K
----
K
-
P
H
I
I
I
A
T
P
G
R
L
--
I
D
H
L
E
N
T
K
-
G
F
N
L
R
A
---
L
K
Y
L
V
M
D
E
A
D
R
I
L
-
N
--
M
-
D
-
F
E
T
E
------
V
----
D
K
I
L
K
V
I
----
P
-------
R
--
D
--
R
-
K
T
F
L
F
S
A
T
M
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
68.37
46%
-121
- C8 -
3MWL
2
?
B:
[3-184]
--------
F
K
-----
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
----
E
R
L
--
A
-
P
S
--
Q
E
---------------
R
--
G
-
R
K
P
--------
R
--
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-
P
------
H
---
L
---
K
V
V
A
-
V
----
Y
G
G
T
G
Y
G
K
-
Q
-
K
E
-
A
L
L
R
----
G
-
A
D
A
V
V
A
T
P
G
R
A
--
L
D
Y
-
L
R
Q
G
-
V
L
D
L
S
R
---
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
------
V
----
E
A
L
L
S
A
T
----
P
-------
P
--
S
--
R
-
Q
T
L
L
F
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
68.23
46%
-114
- C8 -
2GXS
3
?
A:
[3-184]
--------
F
K
-----
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
----
E
R
L
--
A
-
P
S
--
Q
E
---------------
R
--
G
-
R
K
P
--------
R
--
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-
P
------
H
---
L
---
K
V
V
A
-
V
----
Y
G
G
T
G
Y
G
K
-
Q
-
K
E
-
A
L
L
R
----
G
-
A
D
A
V
V
A
T
P
G
R
A
--
L
D
Y
-
L
R
Q
G
-
V
L
D
L
S
R
---
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
------
V
----
E
A
L
L
S
A
T
----
P
-------
P
--
S
--
R
-
Q
T
L
L
F
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
68.08
46%
-110
- C8 -
3NBF
2
?
A:
[3-184]
--------
F
K
-----
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
----
E
R
L
--
A
-
P
S
--
Q
E
---------------
R
--
G
-
R
K
P
--------
R
--
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-
P
------
H
---
L
---
K
V
V
A
-
V
----
Y
G
G
T
G
Y
G
K
-
Q
-
K
E
-
A
L
L
R
----
G
-
A
D
A
V
V
A
T
P
G
R
A
--
L
D
Y
-
L
R
Q
G
-
V
L
D
L
S
R
---
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
------
V
----
E
A
L
L
S
A
T
----
P
-------
P
--
S
--
R
-
Q
T
L
L
F
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
68.04
46%
-118
- C8 -
2GXQ
2
?
A:
[3-184]
--------
F
K
-----
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
----
E
R
L
--
A
-
P
S
--
Q
E
---------------
R
--
G
-
R
K
P
--------
R
--
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-
P
------
H
---
L
---
K
V
V
A
-
V
----
Y
G
G
T
G
Y
G
K
-
Q
-
K
E
-
A
L
L
R
----
G
-
A
D
A
V
V
A
T
P
G
R
A
--
L
D
Y
-
L
R
Q
G
-
V
L
D
L
S
R
---
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
------
V
----
E
A
L
L
S
A
T
----
P
-------
P
--
S
--
R
-
Q
T
L
L
F
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
67.97
46%
-119
- C8 -
3NBF
3
?
C:
[3-184]
--------
F
K
-----
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
----
E
R
L
--
A
-
P
S
--
Q
E
---------------
R
--
G
-
R
K
P
--------
R
--
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-
P
------
H
---
L
---
K
V
V
A
-
V
----
Y
G
G
T
G
Y
G
K
-
Q
-
K
E
-
A
L
L
R
----
G
-
A
D
A
V
V
A
T
P
G
R
A
--
L
D
Y
-
L
R
Q
G
-
V
L
D
L
S
R
---
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
------
V
----
E
A
L
L
S
A
T
----
P
-------
P
--
S
--
R
-
Q
T
L
L
F
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
67.93
46%
-116
- C8 -
3MWK
2
?
B:
[3-184]
--------
F
K
-----
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
----
E
R
L
--
A
-
P
S
--
Q
E
---------------
R
--
G
-
R
K
P
--------
R
--
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-
P
------
H
---
L
---
K
V
V
A
-
V
----
Y
G
G
T
G
Y
G
K
-
Q
-
K
E
-
A
L
L
R
----
G
-
A
D
A
V
V
A
T
P
G
R
A
--
L
D
Y
-
L
R
Q
G
-
V
L
D
L
S
R
---
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
------
V
----
E
A
L
L
S
A
T
----
P
-------
P
--
S
--
R
-
Q
T
L
L
F
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
67.54
43%
-114
- C8 -
2PL3
5
DDX10_HUMAN
A:
[27-213]
--------
F
S
-----
D
F
P
L
S
K
K
T
L
K
G
L
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
L
A
L
--
Q
--
G
--
K
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
----
E
A
L
Y
R
L
-
Q
W
--
T
S
---------------
T
--
D
-
G
L
G
-----------
V
----------------
L
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
L
R
K
V
G
-
K
N
H
----
D
---
F
---
S
A
G
L
-
I
----
I
G
G
--
L
K
H
-
E
-
A
E
-
R
I
-
N
----
N
-
I
N
I
L
V
C
T
P
G
R
L
--
L
Q
H
-
M
D
E
T
V
S
F
H
A
T
D
---
L
Q
M
L
V
L
D
E
A
D
R
I
L
-
D
--
M
-
G
-
F
A
D
T
------
M
----
N
A
V
I
E
N
L
----
P
-------
K
--
K
--
R
-
Q
T
L
L
F
S
A
T
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
67.21
46%
-119
- C8 -
3NBF
2
?
D:
[3-184]
--------
F
K
-----
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
----
G
K
T
L
A
F
A
L
P
I
A
----
E
R
L
--
A
-
P
S
--
Q
E
---------------
R
--
G
-
R
K
P
--------
R
--
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-
P
------
H
---
L
---
K
V
V
A
-
V
----
Y
G
G
T
G
Y
G
K
-
Q
-
K
E
-
A
L
L
R
----
G
-
A
D
A
V
V
A
T
P
G
R
A
--
L
D
Y
-
L
R
Q
G
-
V
L
D
L
S
R
---
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
------
V
----
E
A
L
L
S
A
T
----
P
-------
P
--
S
--
R
-
Q
T
L
L
F
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
66.99
46%
-109
- C8 -
3NBF
2
?
B:
[3-184]
--------
F
K
-----
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
----
E
R
L
--
A
-
P
S
--
Q
E
---------------
R
--
G
-
R
K
P
--------
R
--
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-
P
------
H
---
L
---
K
V
V
A
-
V
----
Y
G
G
T
G
Y
G
K
-
Q
-
K
E
-
A
L
L
R
----
G
-
A
D
A
V
V
A
T
P
G
R
A
--
L
D
Y
-
L
R
Q
G
-
V
L
D
L
S
R
---
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
------
V
----
E
A
L
L
S
A
T
----
P
-------
P
--
S
--
R
-
Q
T
L
L
F
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
66.06
32%
-113
- C8 -
2OXC
1
DDX20_HUMAN
A:
[26-228]
--------
F
E
-----
S
L
L
L
S
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
--
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
----
D
S
L
--
V
-
L
E
--
N
L
---------------
S
--
T
-
Q
I
-----------------------------
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
K
M
E
----
G
---
L
---
E
C
H
V
-
F
----
I
G
G
T
P
L
S
Q
-
D
-
K
T
-
R
L
K
K
----
C
--
H
I
A
V
G
S
P
G
R
I
--
K
Q
L
-
I
E
L
D
-
Y
L
N
P
G
S
---
I
R
L
F
I
L
D
E
A
D
K
L
L
-
E
--
E
-
G
S
F
Q
E
Q
------
I
----
N
W
I
Y
S
S
L
----
P
-------
A
--
S
--
K
-
Q
M
L
A
V
S
A
T
Y
P
-
E
F
L
---
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
65.79
38%
-116
- C8 -
4PX9
1
DDX3X_HUMAN
A:
[67-269]
--------
F
S
-----
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
----
S
Q
I
--
Y
-
S
---
D
G
---------------
P
--
G
-
E
A
L
--------
R
--
A
MKENGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-
Y
R
S
----
R
---
V
---
R
P
C
V
-
V
----
Y
G
G
A
D
I
G
Q
-
Q
-
I
R
-
D
L
E
R
----
G
-
C
H
L
L
V
A
T
P
G
R
L
--
V
D
M
-
M
E
R
G
-
K
I
G
L
D
F
---
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
------
I
R
R
--
I
V
E
Q
D
T
M
----
P
-------
P
--
K
GV
R
-
H
T
M
M
F
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
65.78
37%
-110
- C8 -
1T6N
1
DX39B_HUMAN
B:
[16-201]
--------
F
R
-----
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
--
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
----
Q
Q
L
--------
E
P
---------------
V
--
T
-
G
Q
V
--------
S
--
V
----------------
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
-
K
Y
M
P---
N
---
V
---
K
V
A
V
-
F
----
F
G
G
L
S
I
K
K
-
D
-
E
E
-
V
L
K
K
----
N
C
P
H
I
V
V
G
T
P
G
R
I
--
L
A
L
-
A
R
N
K
-
S
L
N
L
K
H
---
I
K
H
F
I
L
D
E
C
D
K
M
L
-
E
Q-
L
-
D
-
M
R
R
D
------
V
----
Q
E
I
F
R
M
T
----
P
-------
H
--
E
--
K
-
Q
V
M
M
F
S
A
T
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
65.59
32%
-116
- C8 -
3B7G
1
DDX20_HUMAN
B:
[26-228]
--------
F
E
-----
S
L
L
L
S
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
--
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
----
D
S
L
--
V
-
L
E
--
N
L
---------------
S
--
T
-
Q
I
-----------------------------
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
K
M
E
----
G
---
L
---
E
C
H
V
-
F
----
I
G
G
T
P
L
S
Q
-
D
-
K
T
-
R
L
K
K
----
C
--
H
I
A
V
G
S
P
G
R
I
--
K
Q
L
-
I
E
L
D
-
Y
L
N
P
G
S
---
I
R
L
F
I
L
D
E
A
D
K
L
L
-
E
--
E
-
G
S
F
Q
E
Q
------
I
----
N
W
I
Y
S
S
L
----
P
-------
A
--
S
--
K
-
Q
M
L
A
V
S
A
T
Y
P
-
E
F
L
---
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
65.57
38%
-116
- C8 -
4PX9
1
DDX3X_HUMAN
B:
[67-269]
--------
F
S
-----
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
----
S
Q
I
--
Y
-
S
---
D
G
---------------
P
--
G
-
E
A
L
--------
R
--
A
MKENGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-
Y
R
S
----
R
---
V
---
R
P
C
V
-
V
----
Y
G
G
A
D
I
G
Q
-
Q
-
I
R
-
D
L
E
R
----
G
-
C
H
L
L
V
A
T
P
G
R
L
--
V
D
M
-
M
E
R
G
-
K
I
G
L
D
F
---
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
------
I
R
R
--
I
V
E
Q
D
T
M
----
P
-------
P
--
K
GV
R
-
H
T
M
M
F
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
65.14
38%
-116
- C8 -
4PX9
1
DDX3X_HUMAN
C:
[67-269]
--------
F
S
-----
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
----
S
Q
I
--
Y
-
S
---
D
G
---------------
P
--
G
-
E
A
L
--------
R
--
A
MKENGRYGRRKQYPIS
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-
Y
R
S
----
R
---
V
---
R
P
C
V
-
V
----
Y
G
G
A
D
I
G
Q
-
Q
-
I
R
-
D
L
E
R
----
G
-
C
H
L
L
V
A
T
P
G
R
L
--
V
D
M
-
M
E
R
G
-
K
I
G
L
D
F
---
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
------
I
RR--
I
V
E
Q
D
T
M
----
P
-------
P
--
K
GV
R
-
H
T
M
M
F
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
65.04
32%
-114
- C8 -
2OXC
1
DDX20_HUMAN
B:
[26-228]
--------
F
E
-----
S
L
L
L
S
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
--
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
----
D
S
L
--
V
-
L
E
--
N
L
---------------
S
--
T
-
Q
I
-----------------------------
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
K
M
E
----
G
---
L
---
E
C
H
V
-
F
----
I
G
G
T
P
L
S
Q
-
D
-
K
T
-
R
L
K
K
----
C
--
H
I
A
V
G
S
P
G
R
I
--
K
Q
L
-
I
E
L
D
-
Y
L
N
P
G
S
---
I
R
L
F
I
L
D
E
A
D
K
L
L
-
E
--
E
-
G
S
F
Q
E
Q
------
I
----
N
W
I
Y
S
S
L
----
P
-------
A
--
S
--
K
-
Q
M
L
A
V
S
A
T
Y
P
-
E
F
L
---
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
65.04
32%
-112
- C8 -
3B7G
1
DDX20_HUMAN
A:
[26-228]
--------
F
E
-----
S
L
L
L
S
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
--
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
----
D
S
L
--
V
-
L
E
--
N
L
---------------
S
--
T
-
Q
I
-----------------------------
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
K
M
E
----
G
---
L
---
E
C
H
V
-
F
----
I
G
G
T
P
L
S
Q
-
D
-
K
T
-
R
L
K
K
----
C
--
H
I
A
V
G
S
P
G
R
I
--
K
Q
L
-
I
E
L
D
-
Y
L
N
P
G
S
---
I
R
L
F
I
L
D
E
A
D
K
L
L
-
E
--
E
-
G
S
F
Q
E
Q
------
I
----
N
W
I
Y
S
S
L
----
P
-------
A
--
S
--
K
-
Q
M
L
A
V
S
A
T
Y
P
-
E
F
L
---
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
64.77
37%
-106
- C8 -
1T6N
1
DX39B_HUMAN
A:
[16-201]
--------
F
R
-----
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
--
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
----
Q
Q
L
--------
E
P
---------------
V
--
T
-
G
Q
V
--------
S
--
V
----------------
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
-
K
Y
M
P---
N
---
V
---
K
V
A
V
-
F
----
F
G
G
L
S
I
K
K
-
D
-
E
E
-
V
L
K
K
----
N
C
P
H
I
V
V
G
T
P
G
R
I
--
L
A
L
-
A
R
N
K
-
S
L
N
L
K
H
---
I
K
H
F
I
L
D
E
C
D
K
M
L
-
E
Q-
L
-
D
-
M
R
R
D
------
V
----
Q
E
I
F
R
M
T
----
P
-------
H
--
E
--
K
-
Q
V
M
M
F
S
A
T
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
64.52
33%
-115
- C8 -
3FMO
1
DD19B_HUMAN
B:
[84-297]
-
P
N
S
P
L
--
Y
S
V
KSFE
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
EP
P
--
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
----
S
Q
V
--
E
-
P
A
--
N
K
---------------------
Y
P
--------
Q
--
C
----------------
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-
K
F
-----
Y
---
P
---
E
L
K
L
-
A
---------
Y
A
V
-
R
-
G
N
-
K
L
E
R
GQKI
S
-
E
Q
I
V
I
G
T
P
G
T
V
--
L
D
W
---
C
S
-
K
L
K
F
I
D
PKK
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
-
H
Q
D
Q
------
S
----
I
R
I
Q
R
M
L
----
P
-------
R
--
N
--
C
-
Q
M
L
L
F
S
A
T
F
E
D
S
-
V
---
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
63.61
39%
-97
- C8 -
3FE2
3
DDX5_HUMAN
A:
[34-216]
---------
A
-----
N
F
P
A
N
--
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
--
S
--
G
--
L
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
H
I
N
H
Q
P
--
F
-
L
E
RG
D
G
---------------
P
--
I
---------------
C
----------------
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
-
R
A
C
----
R
---
L
---
K
S
T
C
-
I
----
Y
G
G
A
P
K
G
P
-
Q
-
I
R
-
D
L
E
R
----
G
-
V
E
I
C
I
A
T
P
G
R
L
--
I
D
F
-
L
E
C
G
-
K
T
N
L
R
R
---
T
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
------
I
----
R
K
I
V
D
Q
I
----
R
-------
P
--
D
--
R
-
Q
T
L
M
W
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
62.98
39%
-98
- C8 -
3FE2
4
DDX5_HUMAN
B:
[34-216]
---------
A
-----
N
F
P
A
N
--
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
--
S
--
G
--
L
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
VHIN
H
Q
P
--
F
-
L
E
RG
D
G
---------------
P
--
I
---------------
C
----------------
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
-
R
A
C
----
R
---
L
---
K
S
T
C
-
I
----
Y
G
G
A
P
K
G
P
-
Q
-
I
R
-
D
L
E
R
----
G
-
V
E
I
C
I
A
T
P
G
R
L
--
I
D
F
-
L
E
C
G
-
K
T
N
L
R
R
---
T
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
------
I
----
R
K
I
V
D
Q
I
----
R
-------
P
--
D
--
R
-
Q
T
L
M
W
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
59.45
33%
-110
- C8 -
3DKP
4
DDX52_HUMAN
A:
[33-219]
---------------
E
Y
K
I
N
S
R
L
L
Q
N
I
L
D
A
G
F
Q
M
P
T
P
I
Q
M
Q
A
I
P
V
M
L
--
H
--
G
--
R
E
L
L
A
S
A
P
T
G
S
G
K
T
L
A
F
S
I
P
I
L
----
M
Q
L
-----
K
--
Q
P
---------------
A
--
N
-
K
G
F
--------
R
--
A
----------------
L
I
I
S
P
T
R
E
L
A
S
Q
I
H
R
E
L
I
K
I
S
-
E
G
T
----
G
---
F
---
R
I
H
M
-
I
H
K
A
A
V
A
A
K
K
F
-----
G
P
-
K
S
S
K
----
K
-
F
D
I
L
V
T
T
P
N
R
L
I
Y
L
L
K
-
Q
D
P
P
-
G
I
D
L
A
S
---
V
E
W
L
V
V
D
E
S
D
K
L
F
-
E
D
G--
G
-
F
R
D
Q
------
L
----
A
S
I
F
L
A
C
----
T
-------
S
--
H
--
K
V
R
R
A
M
F
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------