@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3537: (2016-02-18 )
MSVRHFLSFMDYSPEELIGLIRRGSELKDLRNRGVLYEPLKSRVLGMVFEKASTRTRLSFEAGMIQLGGQAIFLSPRDTQLGRGEPIGDSARVMSRMLDGVMIRTFAHATLTEFAAHSKVPVINGLSDDLHPCQLLADMQTFHEHRGSIQGKTVAWIGDGNNMCNSYIEAALKFDFQLRVACPEGYEPKAEFVALAGDRLRVVRDPREAVAGAHLVSTDVWASMGQEDEAAARIALFRPYQVNAALLDGAADDVLFMHCLPAHRGEEISEELLDDPRSVAWDQAENRLHAQKALLELLIEHAHYA
Atome Classification :
(44 SA)
.........10........20.......-.30..-......40.........50........60........70.-.......80.-.......90........100..---.....110.......120..-.....130.......140....---..-.150.-----..-----.....--160-........170.......180.......190.----..-------.-------...200------.......210.......220....-...230........-240.......-250-.......260------------------.-------------------......270.......280.......290.......300...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
V
R
H
F
L
S
F
MDY
S
P
E
E
L
I
G
L
I
RRG
S
E
L
K
-
D
L
R
NR-G
V
L
Y
E
P
L
-
K
S
R
V
L
G
M
V
F
EKAST
R
T
R
L
S
FEAG
M
I
Q
LG
G
Q
A
I
-
F
LSPRDTQLG-RGEPIG
D
S
A
R
V
M
S
R
M
L
D
G
V
M
I
R
---
T
F
A
H
A
T
L
T
E
F
AAHSKV
P
V
IN-GLSDD
L
H
P
C
Q
L
L
A
D
M
Q
T
F
H
E
HR---GS-IQG-
K
-----
T
V
-----
A
W
IGD--G-
N
-
N
M
C
N
S
Y
I
E
A
A
L
K
F
D
F
Q
L
R
VACPEGYEP
K
A
E
F
V
----
A
L-------A-------G
D
R
L
R
V
------VR
D
P
R
E
A
VAG
A
H
L
V
S
T
D
V
W
A
SMGQ-E
D
E
A
-A
A
R
I
A
L
F
R
P
-
Y
QV
N
A
A
L
LDG-AAD-
D
V
L
F
MHCLPA------------------H-------------------R
G
E
E
I
S
E
E
L
LDDPRSV
A
W
D
Q
A
EN
R
L
H
A
Q
K
A
L
L
E
L
L
I
E
HAHYA
2
PsiBlast_PDB
96.36
48%
-99
- C9 -
4OH7
3
?
A:
[15-314]
--
I
K
H
F
I
D
L
S
T
V
P
A
T
E
L
R
A
I
L
E
D
A
K
A
R
K
-
A
R
L
K
A
-
G
E
V
E
R
P
Y
-
A
G
K
V
L
A
M
I
F
E
K
L
S
T
R
T
R
V
S
F
D
V
G
M
R
Q
L
G
G
E
T
I
-
M
L
T
G
S
E
M
Q
L
G
-
R
S
E
T
I
A
D
T
A
K
V
L
S
R
Y
V
D
A
I
M
I
R
---
T
T
A
H
E
R
M
L
E
L
A
E
Y
A
T
V
P
V
I
N
-
A
L
T
D
D
T
H
P
C
Q
I
M
A
D
V
L
T
Y
E
E
H
R
---
G
P
-
I
K
G
-
K
-----
T
F
-----
A
W
M
G
D
--
G
-
N
-
N
V
L
H
S
L
V
E
A
A
A
R
F
D
F
N
V
N
I
A
T
P
K
G
S
E
P
K
S
Q
Y
I
----
D
W
-------
A
R
A
N
----
G
A
G
I
M
S
------
T
T
D
P
E
K
A
A
S
G
A
D
C
I
V
T
D
T
W
V
S
M
G
Q
-
E
D
H
A
-
R
G
H
-
N
V
F
I
P
-
Y
Q
V
N
A
N
L
M
A
K
-
A
D
P
-
K
A
L
F
M
H
C
L
P
A
------------------
H
-------------------
R
G
E
E
V
T
D
E
V
I
D
G
P
Q
S
V
V
F
D
E
A
E
N
R
L
H
A
Q
K
A
I
L
A
W
C
L
Q
-----
1
PsiBlast_PDB
95.80
53%
-103
- C9 -
4F2G
8
?
A:
[6-303]
--
I
R
H
Y
L
Q
F
K
D
F
S
L
E
D
Y
E
Y
V
L
E
R
T
G
I
L
K
-
R
K
F
K
N
-
Y
E
T
Y
H
P
L
-
H
D
R
T
L
A
M
I
F
E
K
S
S
T
R
T
R
L
S
F
E
A
G
I
F
Q
L
G
G
H
A
V
-
F
M
S
T
R
D
T
Q
L
G
-
R
G
E
P
V
E
D
S
A
Q
V
I
S
R
M
V
D
I
I
M
I
R
---
T
F
E
Q
D
I
I
Q
R
F
A
E
N
S
R
V
P
V
I
N
-
G
L
T
N
E
Y
H
P
C
Q
V
L
A
D
I
F
T
Y
Y
E
H
R
---
G
P
-
I
R
G
-
K
-----
T
V
-----
A
W
V
G
D
--
A
-
N
-
N
M
L
Y
T
W
I
Q
A
A
R
I
L
D
F
K
L
Q
L
S
T
P
P
G
Y
A
L
D
A
K
L
V
D---
A
E
-------
S
-------
A
P
F
Y
Q
V
------
F
D
D
P
N
E
A
C
K
G
A
D
L
V
T
T
D
V
W
--------------
K
R
A
F
A
D
-
W
C
V
D
E
E
M
M
S
H
-
A
N
S
-
D
A
L
F
M
H
C
L
P
A
------------------
H
-------------------
R
G
E
E
V
T
A
G
V
I
D
G
P
Q
S
V
V
W
D
E
A
E
N
R
L
H
V
Q
K
A
L
M
E
F
L
L
------
4
PsiBlast_PDB
95.32
47%
-92
- C9 -
1A1S
-
OTC_PYRFU
A:
[7-309]
---
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
K
M
F
K
-
I
W
Q
K
I
-
G
K
P
H
R
L
L
-
E
G
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
-
Y
L
N
A
Q
D
L
Q
L
R
-
R
G
E
T
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
---
V
Y
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
-
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
K
K
---
G
T
-
I
K
G
-
V
-----
K
V
-----
V
Y
V
G
D
--
G
-
N
-
N
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
K
V
I
----
K
W
-------
A
E
Q
N
A
A
E
S
G
G
S
F
E
L
------
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
D
V
W
A
S
M
G
Q
-
E
A
E
A
-
E
E
R
R
K
I
F
R
P
-
F
Q
V
N
K
D
L
V
K
H
-
A
K
P
-
D
Y
M
F
M
H
C
L
P
A
------------------
H
-------------------
R
G
E
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
------
3
PsiBlast_PDB
95.26
47%
-96
- C9 -
1PVV
2
OTC_PYRFU
A:
[8-310]
---
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
K
M
F
K
-
I
W
Q
K
I
-
G
K
P
H
R
L
L
-
E
G
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
-
Y
L
N
A
Q
D
L
Q
L
R
-
R
G
E
T
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
---
V
Y
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
-
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
K
K
---
G
T
-
I
K
G
-
V
-----
K
V
-----
V
Y
V
G
D
--
G
-
N
-
N
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
K
V
I
----
K
W
-------
A
E
Q
N
A
A
E
S
G
G
S
F
E
L
------
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
D
V
W
A
S
M
G
Q
-
E
A
E
A
-
E
E
R
R
K
I
F
R
P
-
F
Q
V
N
K
D
L
V
K
H
-
A
K
P
-
D
Y
M
F
M
H
C
L
P
A
------------------
H
-------------------
R
G
E
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
------
21
PsiBlast_CBE
94.82
48%
-99
- C9 -
4OH7
3
?
B:
[15-314]
--
I
K
H
F
I
D
L
S
T
V
P
A
T
E
L
R
A
I
L
E
D
A
K
A
R
K
-
A
R
L
K
A
-
G
E
V
E
R
P
Y
-
A
G
K
V
L
A
M
I
F
E
K
L
S
T
R
T
R
V
S
F
D
V
G
M
R
Q
L
G
G
E
T
I
-
M
L
T
G
S
E
M
Q
L
G
-
R
S
E
T
I
A
D
T
A
K
V
L
S
R
Y
V
D
A
I
M
I
R
---
T
T
A
H
E
R
M
L
E
L
A
E
Y
A
T
V
P
V
I
N
-
A
L
T
D
D
T
H
P
C
Q
I
M
A
D
V
L
T
Y
E
E
H
R
---
G
P
-
I
K
G
-
K
-----
T
F
-----
A
W
M
G
D
--
G
-
N
-
N
V
L
H
S
L
V
E
A
A
A
R
F
D
F
N
V
N
I
A
T
P
K
G
S
---
S
Q
Y
I
----
D
W
-------
A
R
A
N
----
G
A
G
I
M
S
------
T
T
D
P
E
K
A
A
S
G
A
D
C
I
V
T
D
T
W
V
S
M
G
Q
-
E
D
H
A
-
R
G
H
-
N
V
F
I
P
-
Y
Q
V
N
A
N
L
M
A
K
-
A
D
P
-
K
A
L
F
M
H
C
L
P
A
------------------
H
-------------------
R
G
E
E
V
T
D
E
V
I
D
G
P
Q
S
V
V
F
D
E
A
E
N
R
L
H
A
Q
K
A
I
L
A
W
C
L
Q
-----
103
HHSearch
94.76
47%
-95
- C9 -
1PVV
2
OTC_PYRFU
A:
[5-314]
L
A
G
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
K
M
F
K
-
I
W
Q
K
I
-
G
K
P
H
R
L
L
-
E
G
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
-
Y
L
N
A
Q
D
L
Q
L
R
-
R
G
E
T
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
---
V
Y
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
-
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
K
K
---
G
T
-
I
K
G
-
V
-----
K
V
-----
V
Y
V
G
D
--
G
-
N
-
N
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
K
V
I
----
K
W
-------
A
E
Q
N
A
A
E
S
G
G
S
F
E
L
------
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
D
V
W
A
S
M
G
Q
-
E
A
E
A
-
E
E
R
R
K
I
F
R
P
-
F
Q
V
N
K
D
L
V
K
H
-
A
K
P
-
D
Y
M
F
M
H
C
L
P
A
------------------
H
-------------------
R
G
E
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
G
G
I
K
--
5
PsiBlast_PDB
93.29
46%
-103
- C9 -
4NF2
5
OTC_BACAN
A:
[33-329]
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
---
K
N
K
----
Q
E
P
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
-
F
L
N
G
K
E
M
Q
M
Q
-
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
---
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
-
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
---
N
T
-
F
K
G
-
I
-----
K
L
-----
A
Y
V
G
D
--
G
-
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
K
K
--
A
L
-------
A
I
A
K
E
T
--
G
A
E
I
E
I
------
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
G
E
--
E
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
K
H
-
A
K
Q
-
T
Y
H
F
L
H
C
L
P
A
------------------
H
-------------------
R
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
----------
22
PsiBlast_CBE
93.17
46%
-101
- C9 -
4NF2
4
OTC_BACAN
C:
[33-329]
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
---
K
N
K
----
Q
E
P
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
-
F
L
N
G
K
E
M
Q
M
Q
-
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
---
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
-
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
---
N
T
-
F
K
G
-
I
-----
K
L
-----
A
Y
V
G
D
--
G
-
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
KK--
A
L
-------
A
IAKET--
G
A
E
I
E
I
------
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
G
E
--
E
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
K
H
-
A
K
Q
-
T
Y
H
F
L
H
C
L
P
A
------------------
H
-------------------
R
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
----------
23
PsiBlast_CBE
93.04
46%
-101
- C9 -
4NF2
5
OTC_BACAN
B:
[33-329]
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
---
K
N
K
----
Q
E
P
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
-
F
L
N
G
K
E
M
Q
M
Q
-
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
---
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
-
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
---
N
T
-
F
K
G
-
I
-----
K
L
-----
A
Y
V
G
D
--
G
-
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
KK--
A
L
-------
A
IAKET--
G
A
E
I
E
I
------
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
G
E
--
E
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
K
H
-
A
K
Q
-
T
Y
H
F
L
H
C
L
P
A
------------------
H
-------------------
R
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
----------
107
HHSearch
91.17
43%
-95
- C9 -
3TPF
1
OTC_CAMJE
A:
[2-304]
--
M
K
H
F
L
T
L
R
D
F
S
K
E
E
I
L
S
L
V
N
H
A
S
E
L
K
-
K
E
P
K
------
K
L
L
-
Q
D
K
T
L
A
M
I
F
E
K
N
S
T
R
T
R
M
A
F
E
L
A
I
T
E
L
G
G
K
A
L
-
F
L
S
S
N
D
L
Q
L
S
-
R
G
E
P
V
K
D
T
A
R
V
I
G
A
M
V
D
F
V
M
M
R
---
V
N
K
H
E
T
L
L
E
F
A
R
Y
S
K
A
P
V
I
N
-
A
L
S
E
L
Y
H
P
T
Q
V
L
G
D
L
F
T
I
K
E
W
N
---
K
M
-
Q
N
G
I
A
-----
K
V
-----
A
F
I
G
D
--
S
-
N
-
N
M
C
N
S
W
L
I
T
A
A
I
L
G
F
E
I
S
I
A
M
P
K
N
Y
K
I
S
P
E
I
W
----
E
F
-------
A
M
K
Q
A
L
I
S
G
A
K
I
S
L
------
G
Y
D
K
F
E
A
L
K
D
K
D
V
V
I
T
D
T
W
V
S
M
G
E
-
E
N
E
K
-
E
R
K
I
K
E
F
E
G
-
F
M
I
D
E
K
A
M
S
V
-
A
N
K
-
D
A
I
L
L
H
C
L
P
A
------------------
Y
-------------------
R
G
Y
E
V
S
E
E
I
F
E
K
H
A
D
V
I
F
E
E
A
R
N
R
L
Y
V
V
K
A
L
L
C
F
L
D
N
Q
R
---
28
PsiBlast_CBE
91.03
44%
-99
- C9 -
2I6U
5
OTC_MYCTU
C:
[2-307]
--
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
S
R
-
R
P
L
Q
G
P
----
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
T
Q
L
G
-
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
---
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
-
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
---
G
A
-
L
R
G
-
L
-----
R
L
-----
S
Y
F
G
D
--
G
A
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
----
A
A
-------
A
ERRAQDT
G
A
S
V
T
V
------
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
N
D
G
-
L
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
L
-
A
D
S
-
D
A
I
V
L
H
C
L
P
A
------------------
H
-------------------
R
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
---
25
PsiBlast_CBE
90.92
44%
-100
- C9 -
2P2G
3
OTC_MYCTU
D:
[2-307]
--
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
S
R
-
R
P
L
Q
G
P
----
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
T
Q
L
G
-
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
---
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
-
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
---
G
A
-
L
R
G
-
L
-----
R
L
-----
S
Y
F
G
D
--
G
A
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
----
A
A
-------
A
ERRAQDT
G
A
S
V
T
V
------
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
--------------
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
L
-
A
D
S
-
D
A
I
V
L
H
C
L
P
A
------------------
H
-------------------
R
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
---
63
PsiBlast_CBE
90.87
36%
-97
- C9 -
4A8P
4
PTC_ENTFA
B:
[3-309]
---
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
-
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
-
Y
L
A
P
G
Q
I
Q
L
G
-
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
---
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
-
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
PG-
K
K
-
L
E
D
-
C
-----
K
V
-----
V
F
V
G
D
--
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
----
A
K
-------
L
-------
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
-
A
G
A
-
N
C
K
F
M
H
C
L
P
A
------------------
T
-------------------
R
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
------
58
PsiBlast_CBE
90.74
36%
-97
- C9 -
4A8T
3
PTC_ENTFA
A:
[25-331]
---
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
-
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
-
Y
L
A
P
G
-
I
Q
L
G
-
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
---
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
-
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
PEG
K
K
-
L
E
D
-
C
-----
K
V
-----
V
F
V
G
D
--
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
----
A
K
-------
L
-------
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
-
A
G
A
-
N
C
K
F
M
H
C
L
P
A
------------------
T
-------------------
R
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
------
82
PsiBlast_CBE
90.58
36%
-99
- C9 -
4AM8
5
PTC_ENTFA
C:
[3-309]
---
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
-
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
G
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
-
Y
L
A
P
G
Q
I
Q
L
-----
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
---
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
-
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
PEG
K
K
-
L
E
D
-
C
-----
K
V
-----
V
F
V
G
D
--
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
----
A
K
-------
L
-------
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
-
A
G
A
-
N
C
K
F
M
H
C
L
P
A
------------------
T
-------------------
R
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
------
24
PsiBlast_CBE
90.56
44%
-100
- C9 -
2P2G
3
OTC_MYCTU
F:
[2-307]
--
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
S
R
-
R
P
L
Q
G
P
----
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
T
Q
L
G
-
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
---
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
-
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
---
G
A
-
L
R
G
-
L
-----
R
L
-----
S
Y
F
G
D
--
G
A
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
----
A
A
-------
A
ERRAQDT
G
A
S
V
T
V
------
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
--------------
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
L
-
A
D
S
-
D
A
I
V
L
H
C
L
P
A
------------------
H
-------------------
R
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
---
81
PsiBlast_CBE
90.52
36%
-95
- C9 -
4AM8
4
PTC_ENTFA
D:
[3-309]
---
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
-
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
G
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
-
Y
L
A
P
G
Q
I
Q
L
G
-
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
---
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
-
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
PEG
K
K
-
L
E
D
-
C
-----
K
V
-----
V
F
V
G
D
--
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
----
A
K
-------
L
-------
A
K
N
C
E
V
S
G
G
SFL
V
T
D
D
A
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
-
A
G
A
-
N
C
K
F
M
H
C
L
P
A
------------------
T
-------------------
R
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
------
26
PsiBlast_CBE
90.48
44%
-100
- C9 -
2P2G
5
OTC_MYCTU
C:
[2-307]
--
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
S
R
-
R
P
L
Q
G
P
----
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
T
Q
L
G
-
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
---
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
-
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
---
G
A
-
L
R
G
-
L
-----
R
L
-----
S
Y
F
G
D
--
G
A
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
----
A
A
-------
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
------
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
-----------
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
L
-
A
D
S
-
D
A
I
V
L
H
C
L
P
A
------------------
H
-------------------
R
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
---
64
PsiBlast_CBE
90.43
36%
-96
- C9 -
4A8P
3
PTC_ENTFA
A:
[3-309]
---
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
-
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
-
Y
L
A
P
G
Q
I
Q
L
G
-
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
---
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
-
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
PEG
K
K
-
L
E
D
-
C
-----
K
V
-----
V
F
V
G
D
--
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
----
A
K
-------
L
-------
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
-
A
G
A
-
N
C
K
F
M
H
C
L
P
A
------------------
T
-------------------
R
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
------
112
HHSearch
90.39
40%
-95
- C9 -
1DXH
3
OTCC_PSEAE
A:
[4-334]
M
H
N
R
N
L
L
S
L
M
H
H
S
T
R
E
L
R
Y
L
L
D
L
S
R
D
L
K
-
R
A
K
Y
T
-
G
T
E
Q
Q
H
L
-
K
R
K
N
I
A
L
I
F
E
K
T
S
T
R
T
R
C
A
F
E
V
A
A
Y
D
Q
G
A
N
V
T
-
Y
I
D
P
N
S
S
Q
I
G
-
H
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
A
I
E
Y
R
---
G
F
K
Q
E
I
V
E
E
L
A
K
F
A
G
V
P
V
F
N
-
G
L
T
D
E
Y
H
P
T
Q
M
L
A
D
V
L
T
M
R
E
H
S
---
D
K
P
L
H
D
-
I
-----
S
Y
-----
A
Y
L
G
D
--
A
R
N
-
N
M
G
N
S
L
L
L
I
G
A
K
L
G
M
D
V
R
I
A
A
P
K
A
L
W
P
H
D
E
F
V
----
A
Q
-------
C
K
K
F
A
E
E
S
G
A
K
L
T
L
------
T
E
D
P
K
E
A
V
K
G
V
D
F
V
H
T
D
V
W
V
S
M
G
E
-
P
V
E
A
W
G
E
R
I
K
E
L
L
P
-
Y
Q
V
N
M
E
I
M
K
A
T
G
N
P
-
R
A
K
F
M
H
C
L
P
A
------------------
F
HNSET
K
V
G
K
Q
I
A
E
Q
YPNLA
N
G
I
E
V
T
E
D
V
F
E
S
P
Y
N
I
A
F
E
Q
A
E
N
R
M
H
T
I
K
A
I
L
V
S
T
L
A
D
----
65
PsiBlast_CBE
90.29
36%
-96
- C9 -
4A8H
6
PTC_ENTFA
B:
[3-309]
---
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
-
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
-
Y
L
A
P
G
Q
I
Q
L
G
-
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
---
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
-
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
PEG
K
K
-
L
E
D
-
C
-----
K
V
-----
V
F
V
G
D
--
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
----
A
K
-------
L
-------
A
K
N
C
E
V
SGGSFL
V
T
D
D
A
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
-
A
G
A
-
N
C
K
F
M
H
C
L
P
A
------------------
T
-------------------
R
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
------
8
PsiBlast_PDB
90.24
44%
-95
- C9 -
2I6U
5
OTC_MYCTU
A:
[2-307]
--
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
S
R
-
R
P
L
Q
G
P
----
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
T
Q
L
G
-
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
---
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
-
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
---
G
A
-
L
R
G
-
L
-----
R
L
-----
S
Y
F
G
D
--
G
A
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
----
A
A
-------
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
------
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
N
D
G
-
L
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
L
-
A
D
S
-
D
A
I
V
L
H
C
L
P
A
------------------
H
-------------------
R
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
---
29
PsiBlast_CBE
89.96
44%
-95
- C9 -
2I6U
5
OTC_MYCTU
B:
[2-307]
--
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
S
R
-
R
P
L
Q
G
P
----
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
T
Q
L
G
-
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
---
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
-
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
---
G
A
-
L
R
G
-
L
-----
R
L
-----
S
Y
F
G
D
--
G
A
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
----
A
A
-------
A
ERRAQDT
G
A
S
V
T
V
------
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
N
D
G
-
L
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
L
-
A
D
S
-
D
A
I
V
L
H
C
L
P
A
------------------
H
-------------------
R
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
---
106
HHSearch
89.79
45%
-91
- C9 -
2I6U
5
OTC_MYCTU
A:
[2-306]
--
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
-
K
D
P
V
S
---
R
R
P
L
Q
-
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
T
Q
L
G
-
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
---
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
-
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
---
G
A
-
L
R
G
-
L
-----
R
L
-----
S
Y
F
G
D
--
G
-
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
----
A
A
-------
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
------
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
N
D
G
-
L
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
L
-
A
D
S
-
D
A
I
V
L
H
C
L
P
A
------------------
H
-------------------
R
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
----
66
PsiBlast_CBE
89.69
36%
-93
- C9 -
4A8H
6
PTC_ENTFA
A:
[3-309]
---
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
-
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
-
Y
L
A
P
G
Q
I
Q
L
G
-
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
---
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
-
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
PEG
K
K
-
L
E
D
-
C
-----
K
V
-----
V
F
V
G
D
--
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
----
A
K
-------
L
-------
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
-
A
G
A
-
N
C
K
F
M
H
C
L
P
A
------------------
T
-------------------
R
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
------
14
PsiBlast_PDB
89.42
41%
-92
- C9 -
1FVO
1
OTC_HUMAN
A:
[7-297]
---
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
-
G
E
Y
L
P
L
L
-
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
-
F
L
T
T
Q
D
I
H
L
G
-
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
---
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
-
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
-
L
K
G
-
L
-----
T
L
-----
S
W
I
G
D
--
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
----
K
L
-------
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
------
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
V
-
A
A
S
-
D
W
T
F
L
H
C
L
P
-------------------
R
-------------------
K
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
------------------
33
PsiBlast_CBE
89.38
37%
-95
- C9 -
4JQO
6
OTC_VIBVU
C:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
-
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
S
Q
I
G
-
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
---
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
-------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
--
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
----
A
A
C
Q
A
I
A
K
Q
T
-------
G
G
K
I
T
L
------
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM--
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
----------
30
PsiBlast_CBE
89.26
41%
-95
- C9 -
1FVO
1
OTC_HUMAN
B:
[7-297]
---
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
-
G
E
Y
L
P
L
L
-
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
-
F
L
T
T
Q
D
I
H
L
G
-
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
---
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
-
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
-
L
K
G
-
L
-----
T
L
-----
S
W
I
G
D
--
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
----
K
L
-------
A
EQYAKEN
G
T
K
L
L
L
------
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
V
-
A
A
S
-
D
W
T
F
L
H
C
L
P
-------------------
R
-------------------
K
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
------------------
39
PsiBlast_CBE
89.14
37%
-94
- C9 -
4JFR
3
OTC_VIBVU
B:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
-
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
S
Q
I
G
-
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
---
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
-------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
--
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
----
A
A
C
Q
A
I
A
K
Q
T
-------
G
G
K
I
T
L
------
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM--
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
----------
34
PsiBlast_CBE
89.05
37%
-94
- C9 -
4JQO
6
OTC_VIBVU
B:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
-
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
S
Q
I
G
-
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
---
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
-------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
--
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
----
A
A
C
Q
A
I
A
K
Q
T
-------
G
G
K
I
T
L
------
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM--
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
----------
108
HHSearch
89.00
40%
-92
- C9 -
1OTH
1
OTC_HUMAN
A:
[4-314]
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
-
F
R
I
K
Q
K
G
E
Y
L
P
L
L
-
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
-
F
L
T
T
Q
D
I
H
L
G
-
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
---
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
-
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
-
L
K
G
-
L
-----
T
L
-----
S
W
I
G
D
--
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
----
K
L
A
E
Q
Y
A
K
E
N
-------
G
T
K
L
L
L
------
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
V
-
A
A
S
-
D
W
T
F
L
H
C
L
P
R
------------------
K
-------------------
P
-
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
S
P
-
41
PsiBlast_CBE
88.98
37%
-92
- C9 -
4H31
12
OTC_VIBVU
B:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
-
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
S
Q
I
G
-
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
---
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
-------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
--
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
----
A
A
C
Q
A
I
A
K
Q
T
-------
G
G
K
I
T
L
------
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM--
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
----------
20
PsiBlast_PDB
88.96
37%
-91
- C9 -
4JHX
3
OTC_VIBVU
A:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
-
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
S
Q
I
G
-
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
---
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
-------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
--
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
----
A
A
C
Q
A
I
A
K
Q
T
-------
G
G
K
I
T
L
------
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM--
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
----------
18
PsiBlast_PDB
88.74
37%
-93
- C9 -
4H31
14
OTC_VIBVU
A:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
-
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
S
Q
I
G
-
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
---
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
-------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
--
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
----
A
A
C
Q
A
I
A
K
Q
T
-------
G
G
K
I
T
L
------
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM--
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
----------
13
PsiBlast_PDB
88.71
41%
-94
- C9 -
1EP9
1
OTC_HUMAN
A:
[7-297]
---
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
-
G
E
Y
L
P
L
L
-
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
-
F
L
T
T
Q
D
I
H
L
G
-
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
---
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
-
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
-
L
K
G
-
L
-----
T
L
-----
S
W
I
G
D
--
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
----
K
L
-------
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
------
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
V
-
A
A
S
-
D
W
T
F
L
H
C
L
P
-------------------
R
-------------------
K
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
------------------
12
PsiBlast_PDB
88.69
41%
-93
- C9 -
1C9Y
2
OTC_HUMAN
A:
[7-297]
---
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
-
G
E
Y
L
P
L
L
-
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
-
F
L
T
T
Q
D
I
H
L
G
-
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
---
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
-
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
-
L
K
G
-
L
-----
T
L
-----
S
W
I
G
D
--
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
----
K
L
-------
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
------
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
V
-
A
A
S
-
D
W
T
F
L
H
C
L
P
-------------------
R
-------------------
K
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
------------------
11
PsiBlast_PDB
88.34
41%
-92
- C9 -
1OTH
1
OTC_HUMAN
A:
[7-297]
---
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
-
G
E
Y
L
P
L
L
-
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
-
F
L
T
T
Q
D
I
H
L
G
-
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
---
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
-
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
-
L
K
G
-
L
-----
T
L
-----
S
W
I
G
D
--
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
----
K
L
-------
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
------
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
V
-
A
A
S
-
D
W
T
F
L
H
C
L
P
-------------------
R
-------------------
K
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
------------------
35
PsiBlast_CBE
88.31
37%
-94
- C9 -
4JQO
8
OTC_VIBVU
A:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
-
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
S
Q
I
G
-
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
---
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
-------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
--
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
----
A
A
C
Q
A
I
A
K
Q
T
-------
G
G
K
I
T
L
------
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM--
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
----------
19
PsiBlast_PDB
87.77
37%
-95
- C9 -
4JFR
2
OTC_VIBVU
A:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
-
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
S
Q
I
G
-
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
---
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
-------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
--
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
----
A
A
C
Q
A
I
A
K
Q
T
-------
G
G
K
I
T
L
------
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM--
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
----------
53
PsiBlast_CBE
87.71
37%
-92
- C9 -
1DUV
3
OTC1_ECOLI
G:
[6-327]
---
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
-
G
K
E
E
A
K
L
-
T
G
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
-
Y
L
G
P
S
G
S
Q
I
G
-
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
---
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
-
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
-------
L
P
G
-
K
AFNEM
T
L
-----
V
Y
A
G
D
--
A
R
N
-
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
TECR
A
L
-------
A
QQN----
G
G
N
I
T
L
------
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
-
A
K
E
K
W
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
N
P
E
V
K
F
L
H
C
L
P
A
FHDDQTTLGKKMAEEFGL
H
-------------------
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
----------
51
PsiBlast_CBE
86.84
37%
-92
- C9 -
1DUV
2
OTC1_ECOLI
I:
[6-327]
---
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
-
G
K
E
E
A
K
L
-
T
G
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
-
Y
L
G
P
S
G
S
Q
I
G
-
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
---
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
-
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
-------
L
P
G
-
K
AFNEM
T
L
-----
V
Y
A
G
D
--
A
R
N
-
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
TECR
A
L
-------
A
QQN----
G
G
N
I
T
L
------
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
-
A
K
E
K
W
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
N
P
E
V
K
F
L
H
C
L
P
A
FHDDQTTLGKKMAEEFGL
H
-------------------
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
----------
52
PsiBlast_CBE
86.00
37%
-94
- C9 -
1DUV
2
OTC1_ECOLI
H:
[6-327]
---
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
-
G
K
E
E
A
K
L
-
T
G
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
-
Y
L
G
P
S
G
S
Q
I
G
-
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
---
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
-
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
-------
L
P
G
-
K
AFNEM
T
L
-----
V
Y
A
G
D
--
A
R
N
-
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
TECR
A
L
-------
A
QQN----
G
G
N
I
T
L
------
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
-
A
K
E
K
W
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
N
P
E
V
K
F
L
H
C
L
P
A
FHDDQTTLGKKMAEEFGL
H
-------------------
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
----------
91
PsiBlast_CBE
59.88
34%
-90
- C9 -
1F1B
1
PYRB_ECOLI
C:
[7-180]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
-----
A
-
N
P
Q
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
HPQ
E
G
A
A
R
L
A
T
E
F
S
G
N
--
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
---
G
R
-
L
D
N
-
L
-----
H
V
-----
A
M
V
G
D
LK
Y
-
G
-
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
58.69
34%
-91
- C9 -
1F1B
1
PYRB_ECOLI
A:
[7-180]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
-----
A
-
N
P
Q
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
PQ
E
G
A
A
R
L
A
T
E
F
S
G
N
--
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
---
G
R
-
L
D
N
-
L
-----
H
V
-----
A
M
V
G
D
LK
Y
-
G
-
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------