@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3590: (2016-02-18 )
MSEPSIVLIGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDLRVLGGCQLVIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRIAGLHFFNPVPLMRLVEVIEGLATRTGIAERLCALVATFGHQAVRATDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFRMGPFELFDLVGLDVSLPVMESIYRQYYEEPRYRPHPLLRQMLAAGRLGRKSGQGFYRYDGAGQVPVAAPAVAPGAALPPVWLGVDDEHDRAPLLMLLQRLGAEVESGERPSGAPLCLLAPLGADVSAAARRFAVDPTRSLAIDVLSDLERHRCLMACPATRAELQQAARTLFARDGVGVTLIRDSAGFIVQRTLASIVNLACDIAQQGIASVEHIDLAVRLGLGYPLGPLEWGDRLGAGRVLRILERLHALSGDPRYRPSPWLRRRAQLGLSLRQPDSPLAS
Atome Classification :
(44 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50........60----...-----.------.....70........80.-........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250-.....--..--.-----.260..---.....270.......280....-..--.290.......300.......310.......320---.......330.......340.......350..--.------....360.......370.......380.......390--........400.......410.......420.......430......-.440.......450..---.---....460.......470.......480.-.......490.......500.......510
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSEP
S
I
V
L
I
G
I
VGT
G
A
M
G
Q
G
I
A
Q
L
A
A
C
AG
L
S
V
L
L
YDSRQG
V
A
L
Q
A
R
E
Q
I
A
T
V
L
A
R
Q
V
E
RG-----R
L
E
-----
A
------
E
A
V
E
R
A
MGNL
R
V
V
E
D
L
-
R
-
V
LG
G
C
Q
L
V
I
E
A
I
V
E
N
L
E
A
K
Q
A
L
F
R
Q
L
E
E
V
VGD
E
A
I
LASNTS
S
L
S
V
T
A
I
A
S
A
CRDP
G
R
I
A
G
L
HFFNP
V
P
L
M
R
L
V
E
V
I
E
G
L
A
TRT
G
I
A
E
R
L
C
A
L
V
A
T
FGHQ
A
V
RATDSP
G
F
I
V
NHAG
R
A
F
G
T
E
A
L
R
I
L
GEGVA
P
V
A
A
I
D
E
V
L
REGAGFRM
G
P
F
E
L
F
D
L
VGLDVS
L
P
V
M
E
S
I
---
Y
R
Q
Y
Y
--EE--P-----RYR
P
H
P
---
L
L
R
Q
M
L
A
AGRLGRKSGQ
G
F
Y
R
Y-DG--AGQVPVAAPAVAPGAALP
P
V
W
LGVDDEHDRA
P
L
L
---
M
L
L
Q
R
LGAEVESGERPSGA
P
L
C
L
LAPLGA
D
V
S
--
A
------
A
A
R
RFAVDP
T
R
S
L
A
I
D
V
L
S
D
L
E
RH
R
C
L
MACPA
T
R
A
E
---
L
Q
Q
A
A
R
T
L
F
ARDGV
G
V
T
L
I
RDSA
G
F
I
V
Q
R
T
L
A
S
I
V
N
L
A
C
D
I
A
Q
Q
G
I
A
-
S
V
E
H
I
D
L
A
V
R
LGLGYP---L---
G
P
L
E
WGDRLGA
G
R
V
L
R
I
L
E
R
L
H
ALSG-D-PRYRP
S
P
W
L
R
R
R
A
Q
LGLSLRQPDSPLAS
88
HHSearch
96.25
40%
-113
- C3 -
3MOG
1
PAAH_ECOLI
A:
[4-473]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
Q
T
V
A
V
I
G
S
G
T
M
G
A
G
I
A
E
V
A
A
S
H
G
H
Q
V
L
L
Y
D
I
S
A
E
A
L
T
R
A
I
D
G
I
H
A
R
L
N
S
R
V
T
R
G
-----
K
L
T
-----
A
------
E
T
C
E
R
T
L
K
R
L
I
P
V
T
D
I
-
H
-
A
L
A
A
A
D
L
V
I
E
A
A
S
E
R
L
E
V
K
K
A
L
F
A
Q
L
A
E
V
C
P
P
Q
T
L
L
T
T
N
T
S
S
I
S
I
T
A
I
A
A
E
I
K
N
P
E
R
V
A
G
L
H
F
F
N
P
A
P
V
M
K
L
V
E
V
V
S
G
L
A
T
A
A
E
V
V
E
Q
L
C
E
L
T
L
S
W
G
K
Q
P
V
R
C
H
S
T
P
G
F
I
V
N
R
V
A
R
P
Y
Y
S
E
A
W
R
A
L
E
E
Q
V
A
A
P
E
V
I
D
A
A
L
R
D
G
A
G
F
P
M
G
P
L
E
L
T
D
L
I
G
Q
D
V
N
F
A
V
T
C
S
V
---
F
N
A
F
W
--
Q
E
--
R
-----
R
F
L
P
S
L
---
V
Q
Q
E
L
V
I
G
G
R
L
G
K
K
S
G
L
G
V
Y
D
W
-
R
A
--
E
R
E
A
V
V
G
-
L
--------
E
A
V
-------------
S
---
D
-----
S
F
S
P
M
K
V
-
E
---
K
K
S
D
G
V
T
E
I
D
D
V
L
L
I
E
T
QGET
A
Q
A
L
A
I
R
L
A
R
P
V
V
V
I
--
D
K
M
A
--
G
K
V
V
T
I
A
A
A
A
V
N
P
D
S
---
A
T
R
K
A
I
Y
Y
L
Q
Q
Q
G
K
T
V
L
Q
I
A
D
Y
P
G
M
L
I
W
R
T
V
A
M
I
I
N
E
A
L
D
A
L
Q
K
G
V
A
-
S
E
Q
D
I
D
T
A
M
R
L
G
V
N
Y
P
---
Y
---
G
P
L
A
W
G
A
Q
L
G
W
Q
R
I
L
R
L
L
E
N
L
Q
H
H
Y
G
-
E
-
E
R
Y
R
P
C
S
L
L
R
Q
R
A
L
L
E
S
G
Y
---------
1
PsiBlast_PDB
95.88
39%
-113
- C3 -
3MOG
1
PAAH_ECOLI
A:
[4-469]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
Q
T
V
A
V
I
G
S
G
T
M
G
A
G
I
A
E
V
A
A
S
H
G
H
Q
V
L
L
Y
D
I
S
A
E
A
L
T
R
A
I
D
G
I
H
A
R
L
N
S
R
V
T
R
G
-----
K
L
T
-----
A
------
E
T
C
E
R
T
L
K
R
L
I
P
V
T
D
I
-
H
-
A
L
A
A
A
D
L
V
I
E
A
A
S
E
R
L
E
V
K
K
A
L
F
A
Q
L
A
E
V
C
P
P
Q
T
L
L
T
T
N
T
S
S
I
S
I
T
A
I
A
A
E
I
K
N
P
E
R
V
A
G
L
H
F
F
N
P
A
P
V
M
K
L
V
E
V
V
S
G
L
A
T
A
A
E
V
V
E
Q
L
C
E
L
T
L
S
W
G
K
Q
P
V
R
C
H
S
T
P
G
F
I
V
N
R
V
A
R
P
Y
Y
S
E
A
W
R
A
L
E
E
Q
V
A
A
P
E
V
I
D
A
A
L
R
D
G
A
G
F
P
M
G
P
L
E
L
T
D
L
I
G
Q
D
V
N
F
A
V
T
C
S
V
---
F
N
A
F
W
--
Q
E
--
R
-----
R
F
L
P
S
L
---
V
Q
Q
E
L
V
I
G
G
R
L
G
K
K
S
G
L
G
V
Y
D
W
-
R
A
--
E
R
E
A
V
V
G
L
E
A
V
S
D
--
S
F
S
P
--
M
K
V
E
K
K
S
D
G
V
T
E
I
DD
V
L
L
I
E
T
Q
G
E
T
A
Q
A
L
A
I
R
L
A
R
P
V
V
V
I
D
K
M
A
G
K
V
V
--
T
------
I
A
A
A
-
A
V
N
P
D
--------------------
S
A
T
R
K
A
I
Y
Y
L
Q
Q
Q
G
K
T
V
L
Q
--------
I
A
D
Y
P
G
M
L
I
W
R
T
V
A
M
I
I
N
E
A
L
D
A
L
Q
K
G
V
A
-
S
E
Q
D
I
D
T
A
M
R
L
G
V
N
Y
P
---
Y
---
G
P
L
A
W
G
A
Q
L
G
W
Q
R
I
L
R
L
L
E
N
L
Q
H
H
Y
G
-
E
-
E
R
Y
R
P
C
S
L
L
R
Q
R
A
L
L
-------------
21
PsiBlast_CBE
95.68
39%
-113
- C3 -
3MOG
2
PAAH_ECOLI
C:
[4-469]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
Q
T
V
A
V
I
G
S
G
T
M
G
A
G
I
A
E
V
A
A
S
H
G
H
Q
V
L
L
Y
D
I
S
A
E
A
L
T
R
A
I
D
G
I
H
A
R
L
N
S
R
V
T
R
G
-----
K
L
T
-----
A
------
E
T
C
E
R
T
L
K
R
L
I
P
V
T
D
I
-
H
-
A
L
A
A
A
D
L
V
I
E
A
A
S
E
R
L
E
V
K
K
A
L
F
A
Q
L
A
E
V
C
P
P
Q
T
L
L
T
T
N
T
S
S
I
S
I
T
A
I
A
A
E
I
K
N
P
E
R
V
A
G
L
H
F
F
N
P
A
P
V
M
K
L
V
E
V
V
S
G
L
A
T
A
A
E
V
V
E
Q
L
C
E
L
T
L
S
W
G
K
Q
P
V
R
C
H
S
T
P
G
F
I
V
N
R
V
A
R
P
Y
Y
S
E
A
W
R
A
L
E
E
Q
V
A
A
P
E
V
I
D
A
A
L
R
D
G
A
G
F
P
M
G
P
L
E
L
T
D
L
I
G
Q
D
V
N
F
A
V
T
C
S
V
---
F
N
A
F
W
--
Q
E
--
R
-----
R
F
L
P
S
L
---
V
Q
Q
E
L
V
I
G
G
R
L
G
K
K
S
G
L
G
V
Y
D
W
-
R
A
--
E
R
E
A
V
V
G
L
E
A
V
S
D
--
S
F
S
P
--
M
K
V
E
K
K
S
D
G
V
T
E
I
DDV
L
L
I
E
T
Q
G
E
T
A
Q
A
L
A
I
R
L
A
R
P
V
V
V
I
D
K
M
A
G
K
V
V
--
T
------
I
A
A
A
-
A
V
N
P
D
--------------------
S
A
T
R
K
A
IYY
L
Q
Q
Q
G
K
T
V
L
Q
--------
I
A
D
Y
P
G
M
L
I
W
R
T
V
A
M
I
I
N
E
A
L
D
A
L
Q
K
G
V
A
-
S
E
Q
D
I
D
T
A
M
R
L
G
V
N
Y
P
---
Y
---
G
P
L
A
W
G
A
Q
L
G
W
Q
R
I
L
R
L
L
E
N
L
Q
H
H
Y
G
-
E
-
E
R
Y
R
P
C
S
L
L
R
Q
R
A
L
L
-------------
22
PsiBlast_CBE
94.84
39%
-114
- C3 -
3MOG
2
PAAH_ECOLI
B:
[4-469]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
Q
T
V
A
V
I
G
S
G
T
M
G
A
G
I
A
E
V
A
A
S
H
G
H
Q
V
L
L
Y
D
I
S
A
E
A
L
T
R
A
I
D
G
I
H
A
R
L
N
S
R
V
T
R
G
-----
K
L
T
-----
A
------
E
T
C
E
R
T
L
K
R
L
I
P
V
T
D
I
-
H
-
A
L
A
A
A
D
L
V
I
E
A
A
S
E
R
L
E
V
K
K
A
L
F
A
Q
L
A
E
V
C
P
P
Q
T
L
L
T
T
N
T
S
S
I
S
I
T
A
I
A
A
E
I
K
N
P
E
R
V
A
G
L
H
F
F
N
P
A
P
V
M
K
L
V
E
V
V
S
G
L
A
T
A
A
E
V
V
E
Q
L
C
E
L
T
L
S
W
G
K
Q
P
V
R
C
H
S
T
P
G
F
I
V
N
R
V
A
R
P
Y
Y
S
E
A
W
R
A
L
E
E
Q
V
A
A
P
E
V
I
D
A
A
L
R
D
G
A
G
F
P
M
G
P
L
E
L
T
D
L
I
G
Q
D
V
N
F
A
V
T
C
S
V
---
F
N
A
F
W
--
Q
E
--
R
-----
R
F
L
P
S
L
---
V
Q
Q
E
L
V
I
G
G
R
L
G
K
K
S
G
L
G
V
Y
D
W
-
R
A
--
E
R
E
A
V
V
G
L
E
A
V
S
D
--
S
F
S
P
--
M
K
V
E
K
K
S
D
G
V
T
E
I
DDV
L
L
I
E
T
Q
G
E
T
A
Q
A
L
A
I
R
L
A
R
P
V
V
V
I
D
K
M
A
G
K
V
V
--
T
------
I
A
A
A
-
A
V
N
P
D
--------------------
S
A
T
R
K
A
I
Y
Y
L
Q
Q
Q
G
K
T
V
L
Q
--------
I
A
D
Y
P
G
M
L
I
W
R
T
V
A
M
I
I
N
E
A
L
D
A
L
Q
K
G
V
A
-
S
E
Q
D
I
D
T
A
M
R
L
G
V
N
Y
P
---
Y
---
G
P
L
A
W
G
A
Q
L
G
W
Q
R
I
L
R
L
L
E
N
L
Q
H
H
Y
G
-
E
-
E
R
Y
R
P
C
S
L
L
R
Q
R
A
L
L
-------------
114
Fugue
87.68
27%
-109
- C3 -
1WDK
4
FADB_PSEFR
A:
[1-715]
MIYEGKA
I
T
V
T
A
L
E
SG
I
V
E
L
K
F
D
LKGESVNKFN
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
DASVK
G
V
I
V
S
S
GKDVF
I
V
G
A
D
I
T
E
F
V
E
N
F
K
LP
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
LN
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
AD
F
R
V
M
A
DS
A
K
I
G
L
PEVKLGIYPGFGGTV
R
L
P
R
L
IG
V
D
N
A
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
SAVD
A
V
V
T
ADK
L
G
A
A
A
L
D
L
I
K
R
A
I
S
GELD
Y
K
A
K
R
QPKLEKLKLN
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
AGPNYP
A
P
V
E
A
I
K
T
I
Q
K
A
A
NFG
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
Q
E
L
K
K
K
A
K
V
Y
D
K
I
A
K
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
-----
R
M
T
-----
P
------
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
-
G
-
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
-
D
F
V
R
I
D
K
V
M
E
K
F
-
G
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
---
A
E
G
F
P
--
D
R
--
M
-----
K
D
D
R
R
S
---
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
-
E
K
--
K
L
V
D
S
S
V
L
E
V
L
K
P
I
V
Y
E
Q
R
D
V
---------------------------------------------------------------------------------------------------------------------
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
---
L
FRG
G
A
L
R
Y
I
D
S
I
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
L
---
G
-
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
-------
90
HHSearch
81.54
30%
-105
- C3 -
1ZCJ
-
ECHP_RAT
A:
[293-715]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
A
-----
H
Q
N
-----
G
------
Q
--
A
S
A
K
P
K
L
R
F
S
S
S
T
-
K
-
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
S
-
K
P
E
D
V
D
G
V
L
E
-
E
F
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
---
G
L
T
G
P
SL
P
P
GT
P
VRKRG
N
S
R
Y
S
P
---
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
-
D
K
--
P
L
G
R
I
H
K
-
P
D
P
----
W
L
S
T
F
--
L
--------------------------------------------------------------
S
Q
--------------------------------------
Y
R
E
V
H
-
H
I
E
Q
R
T
I
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
RHK
G
---
G
P
M
F
Y
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
-
D
I
P
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
S
P
P
L
K
E
W
Q
S
L
A
-
63
PsiBlast_CBE
79.38
34%
-118
- C3 -
4B3H
5
?
B:
[341-653]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
-----
R
T
T
-----
Q
------
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
-
A
-
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
-
A
S
I
E
Q
A
G
S
Q
-
A
G
Y
P
A
P
P
L
Q
L
S
D
----
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
--
E
D
--
A
GG---
T
Y
Q
P
H
P
A
E
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
KR
S
G
L
W
P
G
L
R
E
T
F
K
S
G
S
S
Q
P
P
L
Q
D
M
I
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
78.66
34%
-117
- C3 -
4B3J
4
?
B:
[341-653]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
-----
R
T
T
-----
Q
------
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
-
A
-
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
-
A
S
I
E
Q
A
G
S
Q
-
A
G
Y
P
A
P
P
L
Q
L
S
D
----
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
--
E
D
--
A
GG---
T
Y
Q
P
H
P
A
E
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
KR
S
G
L
W
P
G
L
R
E
T
F
K
S
G
S
S
Q
P
P
L
Q
D
M
I
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
78.31
34%
-117
- C3 -
4B3I
3
?
B:
[341-653]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
-----
R
T
T
-----
Q
------
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
-
A
-
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
-
A
S
I
E
Q
A
G
S
Q
-
A
G
Y
P
A
P
P
L
Q
L
S
D
----
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
--
E
D
--
A
G
G
---
T
Y
Q
P
H
P
A
E
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
KR
S
G
L
W
P
G
L
R
E
T
F
K
S
G
S
S
Q
P
P
L
Q
D
M
I
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
78.17
26%
-116
- C3 -
3K6J
5
?
A:
[51-441]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
D
V
N
S
V
A
I
I
G
G
G
T
M
G
K
A
M
A
I
C
F
G
L
A
G
I
E
T
F
L
V
V
R
N
E
Q
R
C
K
Q
E
L
E
V
---
M
Y
A
R
E
K
S
F
K
-----
R
L
N
-----
D
------
K
R
I
E
K
I
N
A
N
L
K
I
T
S
D
F
-
H
-
K
L
S
N
C
D
L
I
V
E
S
V
I
E
D
M
K
L
K
K
E
L
F
A
N
L
E
N
I
C
K
S
T
C
I
F
G
T
N
T
S
S
L
D
L
N
E
I
S
S
V
L
R
D
P
S
N
L
V
G
I
H
F
F
N
P
A
N
V
I
R
L
V
E
I
I
Y
G
S
H
T
S
S
Q
A
I
A
T
A
F
Q
A
C
E
S
I
K
K
L
P
V
L
V
G
N
C
K
S
F
V
F
N
R
L
L
H
V
Y
F
D
Q
S
Q
K
L
M
Y
E
Y
G
Y
L
P
H
Q
I
D
K
I
I
T
-
N
F
G
F
L
M
G
P
M
T
V
A
D
M
N
G
F
D
V
M
E
K
L
K
K
E
N
--------------------
G
L
E
P
N
P
---
I
E
K
E
M
W
R
L
K
R
Y
G
R
K
T
N
K
G
F
Y
K
Y
-
D
D
--
K
T
Q
R
K
E
--
N
D
T
----
E
M
E
Q
I
-------------
I
---
R
-------------
R
---
V
------------------------------------------------------------------------
A
K
S
N
I
--
Q
I
I
N
D
Q
D
V
I
N
F
M
L
Y
P
T
V
N
E
G
Y
R
C
I
E
E
G
V
I
S
N
E
S
L
I
D
I
M
F
I
L
G
F
G
W
P
---
I
HSG
G
P
M
R
F
G
K
T
E
G
L
D
K
I
A
N
M
L
V
H
W
S
S
L
E
P
K
E
-
S
A
Y
I
V
A
D
A
L
K
T
A
N
---------------
89
HHSearch
77.81
27%
-117
- C3 -
2WTB
-
MFP2_ARATH
A:
[309-717]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
K
I
K
K
V
A
I
I
G
G
G
L
M
G
S
G
I
A
T
A
L
I
L
S
N
Y
P
V
I
L
K
E
V
N
E
K
F
L
E
A
G
I
G
R
V
K
A
N
L
Q
S
R
V
R
---------
S
-----
Q
------
E
K
F
E
K
T
M
S
L
L
K
G
S
L
D
Y
-
E
-
S
F
R
D
V
D
M
V
I
E
A
V
I
E
N
I
S
L
K
Q
Q
I
F
A
D
L
E
K
Y
C
P
Q
H
C
I
L
A
S
N
T
S
T
I
D
L
N
K
I
G
E
R
T
K
S
Q
D
R
I
V
G
A
H
F
F
S
P
A
H
I
M
P
L
L
E
I
V
R
T
N
H
T
S
A
Q
V
I
V
D
L
L
D
V
G
K
K
I
K
K
T
P
V
V
V
G
N
C
T
G
F
A
V
N
R
M
F
F
P
Y
T
Q
A
A
M
F
L
V
E
C
G
-
A
D
P
Y
L
I
D
R
A
I
S
K
-
F
G
M
P
M
G
P
F
R
L
C
D
L
V
G
F
G
V
A
I
A
T
A
T
Q
F
---
I
E
N
F
---
S
E
--
R
-----
T
Y
-
K
S
M
---
I
I
P
L
M
Q
E
D
K
---------------------------
D
P
----
E
L
K
K
Y
--
I
------------------
E
K
-----------------------------------------
A
R
S
-------------------------------------
I
-
S
G
V
K
L
D
P
K
L
A
N
L
S
E
K
D
I
I
E
M
T
F
F
P
V
V
N
E
A
C
R
V
F
A
E
G
I
A
V
K
A
A
D
L
D
I
A
G
I
M
G
M
G
F
P
---
P
YRG
G
I
M
F
W
A
D
S
I
G
S
K
Y
I
Y
S
R
L
D
E
W
S
K
A
Y
G
-
E
--
F
F
K
P
C
A
F
L
A
E
R
G
S
K
G
V
L
L
S
A
P
------
45
PsiBlast_CBE
77.74
39%
-130
- C3 -
4PZD
1
?
E:
[2-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
R
T
V
G
I
V
G
A
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
V
V
M
V
D
I
S
D
A
A
V
Q
K
G
V
A
T
V
A
S
S
L
D
R
L
I
K
K
E
-----
K
L
T
-----
E
------
A
D
K
A
S
A
L
A
R
I
K
G
S
T
S
Y
-
D
-
D
L
K
A
T
D
I
V
I
E
A
A
T
E
N
Y
D
L
K
V
K
I
L
K
Q
I
D
G
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
A
A
V
T
S
R
A
D
R
F
I
G
M
H
F
F
N
P
V
P
V
M
A
L
V
E
L
I
R
G
L
Q
T
S
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
G
K
Y
P
I
T
V
K
N
S
P
G
F
V
V
N
R
I
L
C
P
M
I
N
E
A
F
C
V
L
G
E
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
H
P
I
G
P
L
A
L
A
D
M
I
G
L
D
T
M
L
A
V
M
E
V
L
---
Y
T
E
-
F
--
A
D
--
P
-----
K
Y
R
P
A
M
---
L
M
R
E
M
V
A
A
G
Y
L
G
R
K
T
G
R
G
V
Y
V
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
HHSearch
77.69
39%
-117
- C3 -
1F0Y
3
HCDH_HUMAN
A:
[12-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
N
P
K
A
G
D
------
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
-
A
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
77.58
39%
-124
- C3 -
4PZE
2
?
E:
[2-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
R
T
V
G
I
V
G
A
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
V
V
M
V
D
I
S
D
A
A
V
Q
K
G
V
A
T
V
A
S
S
L
D
R
L
I
K
K
E
-----
K
L
T
-----
E
------
A
D
K
A
S
A
L
A
R
I
K
G
S
T
S
Y
-
D
-
D
L
K
A
T
D
I
V
I
E
A
A
T
E
N
Y
D
L
K
V
K
I
L
K
Q
I
D
G
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
A
A
V
T
S
R
A
D
R
F
I
G
M
H
F
F
N
P
V
P
V
M
A
L
V
E
L
I
R
G
L
Q
T
S
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
G
K
Y
P
I
T
V
K
N
S
P
G
F
V
V
N
R
I
L
C
P
M
I
N
E
A
F
C
V
L
G
E
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
H
P
I
G
P
L
A
L
A
D
M
I
G
L
D
T
M
L
A
V
M
E
V
L
---
Y
T
E
-
F
--
A
D
--
P
-----
K
Y
R
P
A
M
---
L
M
R
E
M
V
A
A
G
Y
L
G
R
K
T
G
R
G
V
Y
V
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
77.43
39%
-131
- C3 -
4PZD
1
?
B:
[2-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
R
T
V
G
I
V
G
A
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
V
V
M
V
D
I
S
D
A
A
V
Q
K
G
V
A
T
V
A
S
S
L
D
R
L
I
K
K
E
-----
K
L
T
-----
E
------
A
D
K
A
S
A
L
A
R
I
K
G
S
T
S
Y
-
D
-
D
L
K
A
T
D
I
V
I
E
A
A
T
E
N
Y
D
L
K
V
K
I
L
K
Q
I
D
G
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
A
A
V
T
S
R
A
D
R
F
I
G
M
H
F
F
N
P
V
P
V
M
A
L
V
E
L
I
R
G
L
Q
T
S
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
G
K
Y
P
I
T
V
K
N
S
P
G
F
V
V
N
R
I
L
C
P
M
I
N
E
A
F
C
V
L
G
E
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
H
P
I
G
P
L
A
L
A
D
M
I
G
L
D
T
M
L
A
V
M
E
V
L
---
Y
T
E
-
F
--
A
D
--
P
-----
K
Y
R
P
A
M
---
L
M
R
E
M
V
A
A
G
Y
L
G
R
K
T
G
R
G
V
Y
V
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
77.39
39%
-127
- C3 -
4PZE
2
?
D:
[2-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
R
T
V
G
I
V
G
A
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
V
V
M
V
D
I
S
D
A
A
V
Q
K
G
V
A
T
V
A
S
S
L
D
R
L
I
K
K
E
-----
K
L
T
-----
E
------
A
D
K
A
S
A
L
A
R
I
K
G
S
T
S
Y
-
D
-
D
L
K
A
T
D
I
V
I
E
A
A
T
E
N
Y
D
L
K
V
K
I
L
K
Q
I
D
G
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
A
A
V
T
S
R
A
D
R
F
I
G
M
H
F
F
N
P
V
P
V
M
A
L
V
E
L
I
R
G
L
Q
T
S
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
G
K
Y
P
I
T
V
K
N
S
P
G
F
V
V
N
R
I
L
C
P
M
I
N
E
A
F
C
V
L
G
E
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
H
P
I
G
P
L
A
L
A
D
M
I
G
L
D
T
M
L
A
V
M
E
V
L
---
Y
T
E
-
F
--
A
D
--
P
-----
K
Y
R
P
A
M
---
L
M
R
E
M
V
A
A
G
Y
L
G
R
K
T
G
R
G
V
Y
V
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
77.31
34%
-119
- C3 -
4B3H
5
?
A:
[341-653]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
-----
R
T
T
-----
Q
------
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
-
A
-
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
-
A
S
I
E
Q
A
G
S
Q
-
A
G
Y
P
A
P
P
L
Q
L
S
D
----
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
--
E
D
--
A
G
G
---
T
Y
Q
P
H
P
A
E
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
KR
S
G
L
W
P
G
L
R
E
T
F
K
S
G
S
S
Q
P
P
L
Q
D
M
I
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
76.94
39%
-127
- C3 -
4PZE
2
?
H:
[2-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
R
T
V
G
I
V
G
A
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
V
V
M
V
D
I
S
D
A
A
V
Q
K
G
V
A
T
V
A
S
S
L
D
R
L
I
K
K
E
-----
K
L
T
-----
E
------
A
D
K
A
S
A
L
A
R
I
K
G
S
T
S
Y
-
D
-
D
L
K
A
T
D
I
V
I
E
A
A
T
E
N
Y
D
L
K
V
K
I
L
K
Q
I
D
G
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
A
A
V
T
S
R
A
D
R
F
I
G
M
H
F
F
N
P
V
P
V
M
A
L
V
E
L
I
R
G
L
Q
T
S
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
G
K
Y
P
I
T
V
K
N
S
P
G
F
V
V
N
R
I
L
C
P
M
I
N
E
A
F
C
V
L
G
E
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
H
P
I
G
P
L
A
L
A
D
M
I
G
L
D
T
M
L
A
V
M
E
V
L
---
Y
T
E
-
F
--
A
D
--
P
-----
K
Y
R
P
A
M
---
L
M
R
E
M
V
A
A
G
Y
L
G
R
K
T
G
R
G
V
Y
V
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
76.92
39%
-131
- C3 -
4PZD
1
?
H:
[2-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
R
T
V
G
I
V
G
A
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
V
V
M
V
D
I
S
D
A
A
V
Q
K
G
V
A
T
V
A
S
S
L
D
R
L
I
K
K
E
-----
K
L
T
-----
E
------
A
D
K
A
S
A
L
A
R
I
K
G
S
T
S
Y
-
D
-
D
L
K
A
T
D
I
V
I
E
A
A
T
E
N
Y
D
L
K
V
K
I
L
K
Q
I
D
G
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
A
A
V
T
S
R
A
D
R
F
I
G
M
H
F
F
N
P
V
P
V
M
A
L
V
E
L
I
R
G
L
Q
T
S
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
G
K
Y
P
I
T
V
K
N
S
P
G
F
V
V
N
R
I
L
C
P
M
I
N
E
A
F
C
V
L
G
E
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
H
P
I
G
P
L
A
L
A
D
M
I
G
L
D
T
M
L
A
V
M
E
V
L
---
Y
T
E
-
F
--
A
D
--
P
-----
K
Y
R
P
A
M
---
L
M
R
E
M
V
A
A
G
Y
L
G
R
K
T
G
R
G
V
Y
V
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
76.81
39%
-127
- C3 -
4PZE
2
?
B:
[2-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
R
T
V
G
I
V
G
A
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
V
V
M
V
D
I
S
D
A
A
V
Q
K
G
V
A
T
V
A
S
S
L
D
R
L
I
K
K
E
-----
K
L
T
-----
E
------
A
D
K
A
S
A
L
A
R
I
K
G
S
T
S
Y
-
D
-
D
L
K
A
T
D
I
V
I
E
A
A
T
E
N
Y
D
L
K
V
K
I
L
K
Q
I
D
G
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
A
A
V
T
S
R
A
D
R
F
I
G
M
H
F
F
N
P
V
P
V
M
A
L
V
E
L
I
R
G
L
Q
T
S
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
G
K
Y
P
I
T
V
K
N
S
P
G
F
V
V
N
R
I
L
C
P
M
I
N
E
A
F
C
V
L
G
E
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
H
P
I
G
P
L
A
L
A
D
M
I
G
L
D
T
M
L
A
V
M
E
V
L
---
Y
T
E
-
F
--
A
D
--
P
-----
K
Y
R
P
A
M
---
L
M
R
E
M
V
A
A
G
Y
L
G
R
K
T
G
R
G
V
Y
V
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.88
38%
-122
- C3 -
1LSO
1
HCDH_HUMAN
A:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
-
R
K
V
A
K
K
-----
K
F
A
-----
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
A
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.45
38%
-122
- C3 -
1F17
1
HCDH_HUMAN
A:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
-----
N
P
K
A
G
D
-
E
C
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.30
38%
-115
- C3 -
1F0Y
3
HCDH_HUMAN
A:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
-----
N
P
K
A
G
D
-
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
75.24
38%
-120
- C3 -
4KUG
1
?
B:
[6-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
D
R
G
I
A
T
I
T
K
S
L
S
K
L
V
A
K
E
-----
K
I
T
-----
E
------
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
-
K
-
L
A
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
---
Y
N
E
-
T
--
G
D
--
T
-----
K
Y
R
A
S
S
---
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
75.18
38%
-120
- C3 -
1LSJ
1
HCDH_HUMAN
B:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
-----
N
PKAGD-
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
Q
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.18
38%
-116
- C3 -
1M75
3
HCDH_HUMAN
A:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
-----
N
P
K
A
G
D
-
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
75.04
38%
-121
- C3 -
1F17
1
HCDH_HUMAN
B:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
-----
N
PKAGD-
E
C
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Fugue
74.85
37%
-115
- C3 -
1IL0
3
HCDH_HUMAN
A:
[12-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
EN
P
K
A
G
-----
D
------
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
74.51
38%
-115
- C3 -
1IL0
3
HCDH_HUMAN
B:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
-----
N
PKAGD-
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
74.43
38%
-117
- C3 -
4KUG
1
?
C:
[6-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
D
R
G
I
A
T
I
T
K
S
L
S
K
L
V
A
K
E
-----
K
I
T
-----
E
------
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
-
K
-
L
A
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
---
Y
N
E
-
T
--
G
D
--
T
-----
K
Y
R
A
S
S
---
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
74.35
38%
-124
- C3 -
1LSJ
1
HCDH_HUMAN
A:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
-----
N
P
K
A
G
D
-
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
Q
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.31
38%
-114
- C3 -
1M76
3
HCDH_HUMAN
A:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
-----
N
P
K
A
G
D
-
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
C
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
74.17
38%
-118
- C3 -
4KUG
1
?
D:
[6-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
D
R
G
I
A
T
I
T
K
S
L
S
K
L
V
A
K
E
-----
K
I
T
-----
E
------
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
-
K
-
L
A
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
---
Y
N
E
-
T
--
G
D
--
T
-----
K
Y
R
A
S
S
---
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
74.10
38%
-122
- C3 -
3HAD
1
HCDH_HUMAN
B:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
-
R
K
V
A
K
K
-----
K
F
A
-----
E
NPKAGD
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.02
38%
-122
- C3 -
3HDH
1
HCDH_PIG
A:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
-----
N
P
K
A
G
D
-
E
F
V
E
K
T
L
S
S
I
S
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
I
D
G
W
---
H
E
M
D
S
--
Q
N
--
P
-----
L
F
Q
P
S
P
---
A
M
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
73.85
38%
-117
- C3 -
1M76
3
HCDH_HUMAN
B:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
-----
N
PKAGD-
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
C
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
73.77
38%
-119
- C3 -
3HDH
1
HCDH_PIG
B:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
-----
N
PKAGD-
E
F
V
E
K
T
L
S
S
I
S
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
I
D
G
W
---
H
E
M
D
S
--
Q
N
--
P
-----
L
F
Q
P
S
P
---
A
M
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
73.73
38%
-122
- C3 -
1F12
1
HCDH_HUMAN
A:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
-----
N
P
K
A
G
D
-
E
C
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.71
38%
-120
- C3 -
4KUG
1
?
A:
[6-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
D
R
G
I
A
T
I
T
K
S
L
S
K
L
V
A
K
E
-----
K
I
T
-----
E
------
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
-
K
-
L
A
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
---
Y
N
E
-
T
--
G
D
--
T
-----
K
Y
R
A
S
S
---
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
73.61
38%
-122
- C3 -
1LSO
1
HCDH_HUMAN
B:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
-
R
K
V
A
K
K
-----
K
F
A
-----
E
NPKAGD
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
A
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.60
38%
-121
- C3 -
3HAD
1
HCDH_HUMAN
A:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
-
R
K
V
A
K
K
-----
K
F
A
-----
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
73.32
38%
-119
- C3 -
1M75
3
HCDH_HUMAN
B:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
-----
N
PKAGD-
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
73.32
38%
-116
- C3 -
1F0Y
3
HCDH_HUMAN
B:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
-----
N
PKAGD-
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.15
38%
-114
- C3 -
1IL0
3
HCDH_HUMAN
A:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
-----
F
A
E
-----
N
P
K
A
G
D
-
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---
H
E
M
D
A
--
E
N
--
P
-----
L
H
Q
P
S
P
---
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------