@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3607: (2016-02-19 )
MTPPLLEIRNVTRRFGDFTAVDNVSLTINTGEFFTLLGPSGCGKTTLLRMLAGFDQPDSGEIRLNGQDLAGVEPEKRPVHTVFQSYALFPHMSVAQNIAFPLKMAGVAKSEIDARVEQALKDVRLADKGGRMPTQLSGGQRQRVAIARALVNRPRLLLLDEPLSALDAKLREEMQIELINLQKDVGITFVYVTHDQGEALALSHRIAVMNQGRVEQLDAPETIYSFPRSRFVADFIGQCNLLDATVEAVDGERVRIDLRGLGEVQALKSFDAQPGEACVLTLRPEKIRLAQSVTADSDEVHFRGRVAELLYLGDVTLYIVELENGERLETLLPNATPGRAKFFEVGDAVEAAWRFDAGHLVRA
Atome Classification :
(41 SA)
.........10..--....--..20........30........40........50........60.....---...----70....---------------.---...80........90........-100.--.......110.......120.......-130----.......140.......150.......160.......170.......180...---....190.......200.......210.......220.......230.....--..--240....--...250.......---260....---..--.270.......280.......290...-....300.------......310.......320...-....330.......340.......350.......360.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTP
P
L
L
E
I
R
N
V
T
R
--RFGD--
F
T
AV
D
N
V
S
L
T
INTG
E
F
F
T
L
LGPSGC
G
K
T
T
L
L
R
M
L
AGFDQPDS
G
E
I
R
LNG---QDL----AGVEPE---------------K---R
P
V
H
T
V
F
Q
S
Y
ALFP
H
M
S
V
A
Q
NIA-
F
-
P
L
--
K
MAGV
A
K
S
E
I
D
A
R
V
E
Q
A
L
K
D
V
RLADKG-GRM----PTQLSGG
Q
R
Q
R
V
A
I
A
R
A
L
VNRP
R
L
L
L
LDE
P
L
S
A
L
D
A
K
L
R
E
E
M
Q
I
E
L
I
N
LQKDV---
G
I
T
F
V
Y
V
THDQG
E
A
L
A
L
S
H
R
I
A
VMNQGRVEQLDA
P
E
T
I
Y
SF
P
R
S
R
F
V
A
D
F
I
G--QC--NLL
D
A
T
V--EAVDG
E
R
V
R
I
D
LR---GL
G
E
V
Q
A
---
L
K
--SFDAQPG
E
A
C
V
L
T
LRPE
K
I
R
L
A
QSVTA-DSD
E
V
H
FR------
G
R
V
A
E
L
L
Y
LG
D
V
T
L
Y
I
V
ELENG-
E
R
L
E
T
LLPNATPGR
A
K
F
F
EVG
D
A
V
E
A
A
WRFDAGHLVRA
115
HHSearch
90.87
40%
-104
- C2 -
3RLF
3
MALK_ECOLI
A:
[2-356]
---
A
S
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
MPN
R
Q
Q
V
W
L
P
---
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
------
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
-
Q
N
----
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
-
1
PsiBlast_PDB
89.27
42%
-115
- C2 -
1V43
-
?
A:
[13-363]
-----
V
K
L
E
N
L
T
K
--
R
F
G
N
--
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
---
R
D
V
----
T
Y
L
P
P
K
---------------
D
---
R
N
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
-
F
-
P
L
----
K
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
-
N
R
Y
----
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
---
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
AP
E
M
--
N
I
L
E
V
S
V
G
D
G
Y
L
E
G
R
G
F
R
I
E
L
P
---
Q
---
M
D
L
---
L
K
--
D
Y
---
V
G
K
T
V
L
F
G
I
R
P
E
H
M
----
T
V
E
G
-
V
----
H
M
K
R
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
--
E
L
V
K
V
K
L
P
G
H
I
P
-----
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
---
14
PsiBlast_PDB
88.89
43%
-111
- C2 -
3PUV
5
MALK_ECOLI
A:
[4-314]
-----
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
M
--
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
---
M
P
N
R
Q
Q
V
W
L
P
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
-----
L
P
S
-
D
I
A
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
------------------------------------------------
12
PsiBlast_PDB
87.85
43%
-109
- C2 -
3PUZ
2
MALK_ECOLI
A:
[4-314]
-----
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
M
--
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
---
M
P
N
R
Q
Q
V
W
L
P
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
-----
L
P
S
-
D
I
A
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
------------------------------------------------
20
PsiBlast_PDB
87.82
43%
-110
- C2 -
4KI0
4
?
A:
[4-314]
-----
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
M
--
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
---
M
P
N
R
Q
Q
V
W
L
P
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
-----
L
P
S
-
D
I
A
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
------------------------------------------------
24
PsiBlast_CBE
87.72
43%
-109
- C2 -
3PUZ
2
MALK_ECOLI
B:
[4-314]
-----
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
M
--
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
---
M
P
N
R
Q
Q
V
WLP
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
-----
L
P
S
-
D
I
A
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
------------------------------------------------
17
PsiBlast_PDB
87.71
43%
-111
- C2 -
3RLF
3
MALK_ECOLI
A:
[4-314]
-----
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
M
--
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
---
M
P
N
R
Q
Q
V
W
L
P
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
-----
L
P
S
-
D
I
A
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
------------------------------------------------
15
PsiBlast_PDB
87.62
43%
-111
- C2 -
3PUW
5
MALK_ECOLI
A:
[4-314]
-----
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
M
--
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
---
M
P
N
R
Q
Q
V
W
L
P
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
-----
L
P
S
-
D
I
A
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
------------------------------------------------
29
PsiBlast_CBE
87.53
43%
-110
- C2 -
2AWN
2
MALK_ECOLI
B:
[4-314]
-----
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
M
--
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
---
M
P
N
R
Q
Q
V
W
L
P
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
-----
L
P
S
-
D
I
A
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
------------------------------------------------
112
HHSearch
87.31
41%
-103
- C2 -
2YYZ
3
?
A:
[2-352]
---
P
S
I
R
V
V
N
L
K
K
--
Y
F
G
K
--
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
---
V
L
V
----
N
D
I
P
P
K
---------------
Y
---
R
E
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
-
F
-
P
L
--
R
A
R
R
I
S
K
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
D
N
L
L
-
D
R
K
----
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
---
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
G
--
N
P
P
T
N
F
L
R
D
F
S
--
V
S
V
E
N
K
Q
T
I
L
K
R
D
---
D
V
I
I
K
L
P
---
E
----
P
V
D
V
K
L
K
E
V
V
V
G
I
R
P
E
H
C
R
I
S
R
E
R
-----
V
E
N
S
I
P
------
G
V
V
Y
V
V
E
P
L
G
R
D
I
I
V
N
V
K
T
E
K
G
-
E
I
I
K
V
F
G
D
-----
T
G
K
A
P
Q
P
G
E
N
V
F
L
V
P
D
L
R
K
I
H
L
F
N
P
11
PsiBlast_PDB
87.28
43%
-109
- C2 -
3PUY
3
MALK_ECOLI
A:
[4-314]
-----
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
M
--
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
---
M
P
N
R
Q
Q
V
W
L
P
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
-----
L
P
S
-
D
I
A
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
------------------------------------------------
23
PsiBlast_CBE
87.22
43%
-110
- C2 -
3RLF
3
MALK_ECOLI
B:
[4-314]
-----
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
M
--
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
---
M
P
N
R
Q
Q
V
WLP
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
-----
L
P
S
-
D
I
A
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
------------------------------------------------
16
PsiBlast_PDB
87.19
43%
-110
- C2 -
3PUX
5
MALK_ECOLI
A:
[4-314]
-----
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
M
--
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
---
M
P
N
R
Q
Q
V
W
L
P
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
-----
L
P
S
-
D
I
A
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
------------------------------------------------
2
PsiBlast_PDB
87.11
42%
-112
- C2 -
1VCI
1
?
A:
[13-363]
-----
V
K
L
E
N
L
T
K
--
R
F
G
N
--
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
---
R
D
V
----
T
Y
L
P
P
K
---------------
D
---
R
N
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
-
F
-
P
L
----
K
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
-
N
R
Y
----
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
---
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
AP
E
M
--
N
I
L
E
V
S
V
G
D
G
Y
L
E
G
R
G
F
R
I
E
L
P
---
Q
---
M
D
L
---
L
K
--
D
Y
---
V
G
K
T
V
L
F
G
I
R
P
E
H
M
----
T
V
E
G
-
V
----
H
M
K
R
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
--
E
L
V
K
V
K
L
P
G
H
I
P
-----
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
---
34
PsiBlast_CBE
86.93
42%
-109
- C2 -
2R6G
2
MALK_ECOLI (first)
A:
[4-314]
-----
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
M
--
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
---
M
P
N
R
Q
Q
V
W
L
P
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
-----
L
P
S
-
D
I
A
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
------------------------------------------------
111
HHSearch
86.85
42%
-99
- C2 -
1V43
-
?
A:
[9-366]
-
K
M
V
E
V
K
L
E
N
L
T
K
--
R
F
G
N
--
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
---
R
D
V
----
T
Y
L
P
P
K
---------------
D
---
R
N
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
-
F
-
P
L
----
K
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
-
N
R
Y
----
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
---
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
--
A
P
EM
N
I
L
E
V
S
V
--
G
D
G
Y
L
E
-----
G
R
---
G
F
R
I
E
L
P
---
Q
-MD
L
L
K
D
Y
V
G
K
T
V
L
F
G
I
R
P
E
H
M
T
V
E
G
V
---H
M
K
R
T
A
R
L
I
------
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
--
E
L
V
K
V
K
L
P
G
-----
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
19
PsiBlast_PDB
86.63
43%
-111
- C2 -
4KHZ
-
?
A:
[4-314]
-----
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
M
--
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
---
M
P
N
R
Q
Q
V
W
L
P
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
-----
L
P
S
-
D
I
A
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
------------------------------------------------
33
PsiBlast_CBE
86.50
42%
-111
- C2 -
2R6G
2
MALK_ECOLI (first)
B:
[4-314]
-----
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
M
--
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
---
M
P
N
R
Q
Q
V
WLP
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
-----
L
P
S
-
D
I
A
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
------------------------------------------------
22
PsiBlast_CBE
85.96
43%
-107
- C2 -
4KI0
3
?
B:
[4-314]
-----
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
M
--
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
---
M
P
N
R
Q
Q
V
WLP
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
-----
L
P
S
-
D
I
A
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
------------------------------------------------
13
PsiBlast_PDB
85.87
43%
-107
- C2 -
3PV0
-
MALK_ECOLI
A:
[4-314]
-----
V
Q
L
Q
N
V
T
K
--
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
----
N
D
T
P
P
A
---------------
E
---
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
--
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
-
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
M
--
N
F
L
P
V
K
V
--
T
A
T
A
I
D
Q
V
Q
V
E
L
P
---
M
P
N
R
Q
Q
V
W
L
P
V
E
--
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
-----
L
P
S
-
D
I
A
D
V
I
L
E
------
G
E
V
Q
V
V
E
Q
L
G
N
E
T
------------------------------------------------
48
PsiBlast_CBE
75.22
37%
-102
- C2 -
3FVQ
3
FBPC_NEIG1
A:
[5-301]
-----
L
H
I
G
H
L
S
K
--
S
F
Q
N
--
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
---
K
T
I
FSKN
T
N
L
P
V
R
---------------
E
---
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
-
Y
-
G
L
--
G
N
G
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
-
G
R
Y
----
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
---
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
--
E
G
--
I
V
F
P
A
A
L
--
N
A
D
G
T
A
D
C
R
L
------
G
R
L
P
V
Q
S
---------
G
A
P
A
G
T
R
G
T
L
L
I
R
P
E
Q
Y
S
L
-
H
P
H
S
A
-
P
A
A
S
I
H
---------------------------------------------------------------------
47
PsiBlast_CBE
75.16
37%
-102
- C2 -
3FVQ
3
FBPC_NEIG1
B:
[5-296]
-----
L
H
I
G
H
L
S
K
--
S
F
Q
N
--
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
---
K
T
I
FSKN
T
N
L
P
V
R
---------------
E
---
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
-
Y
-
G
L
--
G
N
G
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
-
G
R
Y
----
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
---
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
--
E
G
--
I
V
F
P
A
A
L
--
N
A
D
G
T
A
D
C
R
L
------
G
R
L
P
V
Q
S
---------
G
A
P
A
G
T
R
G
T
L
L
I
R
P
E
Q
Y
S
L
-
H
P
H
S
A
-
P
A
A
S
I
H
---------------------------------------------------------------------
59
PsiBlast_CBE
60.16
34%
-102
- C2 -
4YMV
1
?
A:
[1-239]
----
M
I
F
V
N
D
V
Y
K
--
N
F
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
NNGK
V
N
I
N
K
V
---------------
R
---
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
V
--
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
--
K
I
------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
59.96
34%
-104
- C2 -
4YMV
1
?
J:
[1-239]
----
M
I
F
V
N
D
V
Y
K
--
N
F
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
NNGK
V
N
I
N
K
V
---------------
R
---
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
V
--
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
--
K
I
------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
59.88
34%
-107
- C2 -
4YMU
2
?
A:
[1-239]
----
M
I
F
V
N
D
V
Y
K
--
N
F
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
NNGK
V
N
I
N
K
V
---------------
R
---
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
V
--
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
--
K
I
------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
59.74
32%
-106
- C2 -
1B0U
4
HISP_SALTY
A:
[5-253]
---
N
K
L
H
V
I
D
L
H
K
--
R
Y
G
G
--
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
---
Q
N
I
----
N
L
V
R
D
K
DGQLKVAD
K
N
Q
L
R
L
L
R
---
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
-
P
I
--
Q
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
G
K
Y
----
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
-
L
R
I
M
Q
Q
L
A
E
E
---
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
59.49
34%
-105
- C2 -
3C41
3
?
K:
[3-241]
----
M
I
D
V
H
Q
L
K
K
--
S
F
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
----
K
A
K
D
T
N
LNKV-----------
R
---
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
--
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
V
------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
59.22
34%
-104
- C2 -
2OLK
1
?
A:
[24-262]
----
M
I
D
V
H
Q
L
K
K
--
S
F
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
----
K
A
K
D
T
N
L
N
K
V
-----------
R
---
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
--
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
V
------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
59.22
34%
-100
- C2 -
2OLK
1
?
D:
[24-262]
----
M
I
D
V
H
Q
L
K
K
--
S
F
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
----
K
A
K
D
T
N
LNKV-----------
R
---
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
--
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
V
------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
59.21
34%
-108
- C2 -
3C4J
4
?
B:
[24-262]
----
M
I
D
V
H
Q
L
K
K
--
S
F
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
----
K
A
K
D
T
N
LNKV-----------
R
---
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
--
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
V
------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
59.15
34%
-105
- C2 -
4YMU
2
?
J:
[1-239]
----
M
I
F
V
N
D
V
Y
K
--
N
F
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
NNGK
V
N
I
N
K
V
---------------
R
---
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
V
--
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
--
K
I
------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
58.93
34%
-103
- C2 -
2OLJ
4
?
A:
[24-262]
----
M
I
D
V
H
Q
L
K
K
--
S
F
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
----
K
A
K
D
T
N
L
N
K
V
-----------
R
---
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
--
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
V
------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
58.78
34%
-104
- C2 -
3C41
3
?
J:
[3-241]
----
M
I
D
V
H
Q
L
K
K
--
S
F
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
----
K
A
K
D
T
N
LNKV-----------
R
---
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
--
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
V
------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
58.58
34%
-102
- C2 -
2Q0H
4
?
A:
[24-262]
----
M
I
D
V
H
Q
L
K
K
--
S
F
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
----
K
A
K
D
T
N
L
N
K
V
-----------
R
---
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
--
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
V
------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
58.55
34%
-104
- C2 -
2OLK
1
?
C:
[24-262]
----
M
I
D
V
H
Q
L
K
K
--
S
F
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
----
K
A
K
D
T
N
LNKV-----------
R
---
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
--
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
V
------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
58.35
34%
-102
- C2 -
4U00
3
?
A:
[3-238]
---
P
I
I
R
I
R
N
L
H
K
--
W
F
G
P
--
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
LSV
K
D
D
----
R
A
L
R
E
I
---------------
R
---
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
-
L
A
P
M
--
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
K
Y
----
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
58.09
34%
-101
- C2 -
2OLJ
3
?
B:
[24-262]
----
M
I
D
V
H
Q
L
K
K
--
S
F
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
----
K
A
K
D
T
N
LNKV-----------
R
---
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
--
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
V
------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
57.66
34%
-98
- C2 -
2OLK
2
?
B:
[24-262]
----
M
I
D
V
H
Q
L
K
K
--
S
F
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
----
K
A
K
D
T
N
LNKV-----------
R
---
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
--
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
V
------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
57.38
34%
-100
- C2 -
3C4J
3
?
A:
[24-262]
----
M
I
D
V
H
Q
L
K
K
--
S
F
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
----
K
A
K
D
T
N
L
N
K
V
-----------
R
---
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
--
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
V
------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
56.22
34%
-100
- C2 -
2Q0H
4
?
B:
[24-262]
----
M
I
D
V
H
Q
L
K
K
--
S
F
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
----
K
A
K
D
T
N
L
N
K
V
-----------
R
---
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
--
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
V
------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
53.12
37%
-95
- C2 -
3TIF
7
Y796_METJA
B:
[1-225]
----
M
V
K
L
K
N
V
T
K
TY
K
M
G
E
EI
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
IKT
N
D
L
----
D
D
D
E
L
T
---------------
K
IRR
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-
P
L
IF
K
Y
R
G
A
M
S
G
E
--
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
F
ANHK
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
---
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------