@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3629: (2016-02-19 )
MIKSRAAVAFAPNKPLEIVEVDVAPPQKGEVLVRIVATGVCHTDAYTLSGQDSEGVFPCILGHEGGGIVEAVGEGVTSLQVGDHVIPLYTAECGKCKFCLSGKTNLCQAVRATQGKGLMPDGTSRFSYKGEPVFHYMGCSTFSEYTVLPEISLAKIPKDAPLEKVCLLGCGVTTGIGAVLNTAKVEEGATVAIFGLGGIGLAAIIGAKMAKAARIIAVDINPGKFDIARELGATDFINPKDYDKPIQDVIVELTDGGVDYSFECVGNVQLMRAALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVRGRSELPSYVEKAQKGEIPLDTFITHTMGLEDINEAFELMHEGKSIRTVIHY
Atome Classification :
(83 SA)
---.........10........20........30........40.....-..-.50........60........70........80........90........100.......110...-.----.-..120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250....-...260.......270...-...-.280-.......290.......300.......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MIKS
R
A
A
V
A
FAPNK
P
L
E
I
V
E
V
DVAPPQKG
E
V
L
V
R
I
V
ATGVCHT
D
A
Y
-
T
L-SGQDSEG
V
F
P
C
I
LGHEGG
G
I
V
E
A
V
GEGV
T
S
LQVGD
H
V
I
P
L
Y
TAECG
K
C
K
F
C
LSG
K
T
N
L
C
Q
A
V
R
ATQG-K----G-LMPDGTSRFSYKGE
P
V
F
H
Y
MGCSTFSEYTVLPE
I
S
L
AKIPKDA
P
L
E
K
V
C
LLGCG
V
T
T
G
I
G
A
V
L
N
T
A
KVEEG
A
T
V
A
I
F
GLG
G
I
G
L
A
A
I
I
G
A
K
M
AK
A
A
R
I
I
A
V
DINPG
K
F
D
I
A
R
ELGATDFI
N
P
K
DYDK
P
I
Q
D
V
I
V
ELTDG-GV
D
Y
S
F
E
CVG
N
V
Q
L
M
R
A
A
L
-
E
C
C
-
H
KGW-G
E
S
V
I
I
G
VAGAGQEISTR
P
F
Q
L
V
TGRVWRGSAFGGVRG
R
S
E
L
P
S
Y
V
E
KAQKGEI
P
L
D
T
F
I
T
H
TM
G
L
E
D
I
N
E
A
F
E
L
M
HEGK
S
I
R
T
V
IHY
49
PsiBlast_CBE
94.26
64%
-119
- C1 -
3QJ5
10
ADHX_HUMAN
B:
[5-372]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
41
PsiBlast_CBE
93.70
65%
-121
- C1 -
4DLB
5
?
B:
[24-392]
---
V
I
T
C
K
A
A
V
A
W
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
V
K
V
L
Y
T
A
L
C
H
T
D
A
Y
-
T
W
-
S
G
K
D
P
E
G
L
F
P
C
V
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
P
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
A
A
T
G
-
V
----
G
V
M
M
N
D
R
K
S
R
F
S
I
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
V
A
P
L
E
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
I
V
A
V
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
A
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
F
D
R
A
K
N
F
G
V
T
E
F
I
N
P
K
E
H
E
Q
P
I
Q
Q
V
I
V
D
L
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
S
A
L
-
E
C
C
-
H
K
G
W
-
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
S
Q
V
P
S
L
V
D
K
Y
L
K
K
E
I
K
V
D
E
Y
I
T
H
N
M
T
L
A
D
I
N
K
A
F
D
L
M
H
D
G
D
C
L
R
V
V
L
--
23
PsiBlast_PDB
93.59
65%
-119
- C1 -
4DLB
6
?
A:
[24-392]
---
V
I
T
C
K
A
A
V
A
W
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
V
K
V
L
Y
T
A
L
C
H
T
D
A
Y
-
T
W
-
S
G
K
D
P
E
G
L
F
P
C
V
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
P
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
A
A
T
G
-
V
----
G
V
M
M
N
D
R
K
S
R
F
S
I
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
V
A
P
L
E
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
I
V
A
V
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
A
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
F
D
R
A
K
N
F
G
V
T
E
F
I
N
P
K
E
H
E
Q
P
I
Q
Q
V
I
V
D
L
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
S
A
L
-
E
C
C
-
H
K
G
W
-
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
S
Q
V
P
S
L
V
D
K
Y
L
K
K
E
I
K
V
D
E
Y
I
T
H
N
M
T
L
A
D
I
N
K
A
F
D
L
M
H
D
G
D
C
L
R
V
V
L
--
56
PsiBlast_CBE
93.30
64%
-119
- C1 -
2FZW
6
ADHX_HUMAN
B:
[4-371]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
L
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
53
PsiBlast_CBE
93.30
64%
-120
- C1 -
1MA0
7
ADHX_HUMAN
B:
[4-371]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
42
PsiBlast_CBE
93.02
65%
-121
- C1 -
4DLA
8
?
B:
[24-392]
---
V
I
T
C
K
A
A
V
A
W
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
V
K
V
L
Y
T
A
L
C
H
T
D
A
Y
-
T
W
-
S
G
K
D
P
E
G
L
F
P
C
V
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
P
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
A
A
T
G
-
V
----
G
V
M
M
N
D
R
K
S
R
F
S
I
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
V
A
P
L
E
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
I
V
A
V
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
A
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
F
D
R
A
K
N
F
G
V
T
E
F
I
N
P
K
E
H
E
Q
P
I
Q
Q
V
I
V
D
L
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
S
A
L
-
E
C
C
-
H
K
G
W
-
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
S
Q
V
P
S
L
V
D
K
Y
L
K
K
E
I
K
V
D
E
Y
I
T
H
N
M
T
L
A
D
I
N
K
A
F
D
L
M
H
D
G
D
C
L
R
V
V
L
--
22
PsiBlast_PDB
92.77
65%
-119
- C1 -
4DLA
6
?
A:
[24-392]
---
V
I
T
C
K
A
A
V
A
W
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
V
K
V
L
Y
T
A
L
C
H
T
D
A
Y
-
T
W
-
S
G
K
D
P
E
G
L
F
P
C
V
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
P
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
A
A
T
G
-
V
----
G
V
M
M
N
D
R
K
S
R
F
S
I
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
V
A
P
L
E
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
I
V
A
V
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
A
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
F
D
R
A
K
N
F
G
V
T
E
F
I
N
P
K
E
H
E
Q
P
I
Q
Q
V
I
V
D
L
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
S
A
L
-
E
C
C
-
H
K
G
W
-
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
S
Q
V
P
S
L
V
D
K
Y
L
K
K
E
I
K
V
D
E
Y
I
T
H
N
M
T
L
A
D
I
N
K
A
F
D
L
M
H
D
G
D
C
L
R
V
V
L
--
21
PsiBlast_PDB
92.74
65%
-119
- C1 -
4DL9
6
?
A:
[24-392]
---
V
I
T
C
K
A
A
V
A
W
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
V
K
V
L
Y
T
A
L
C
H
T
D
A
Y
-
T
W
-
S
G
K
D
P
E
G
L
F
P
C
V
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
P
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
A
A
T
G
-
V
----
G
V
M
M
N
D
R
K
S
R
F
S
I
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
V
A
P
L
E
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
I
V
A
V
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
A
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
F
D
R
A
K
N
F
G
V
T
E
F
I
N
P
K
E
H
E
Q
P
I
Q
Q
V
I
V
D
L
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
S
A
L
-
E
C
C
-
H
K
G
W
-
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
S
Q
V
P
S
L
V
D
K
Y
L
K
K
E
I
K
V
D
E
Y
I
T
H
N
M
T
L
A
D
I
N
K
A
F
D
L
M
H
D
G
D
C
L
R
V
V
L
--
1
HHSearch
92.70
64%
-119
- C1 -
2FZW
6
ADHX_HUMAN
A:
[4-372]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
L
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
K
-
46
PsiBlast_CBE
92.60
64%
-120
- C1 -
4GL4
10
ADHX_ARATH
B:
[6-374]
---
V
I
T
C
K
A
A
V
A
Y
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
I
K
I
L
Y
T
A
L
C
H
T
D
A
Y
-
T
W
-
S
G
K
D
P
E
G
L
F
P
C
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
A
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
S
A
T
G
-
V
----
G
I
M
M
N
D
R
K
S
R
F
S
V
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
T
A
P
L
D
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
N
V
A
I
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
T
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
Y
E
T
A
K
K
F
G
V
N
E
F
V
N
P
K
D
H
D
K
P
I
Q
E
V
I
V
D
L
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
A
A
L
-
E
C
C
-
H
K
G
W
-
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
T
Q
V
P
W
L
V
E
K
Y
M
N
K
E
I
K
V
D
E
Y
I
T
H
N
L
T
L
G
E
I
N
K
A
F
D
L
L
H
E
G
T
C
L
R
C
V
L
--
52
PsiBlast_CBE
92.54
64%
-118
- C1 -
1MP0
6
ADHX_HUMAN
B:
[4-371]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
50
PsiBlast_CBE
92.35
64%
-118
- C1 -
2FZE
6
ADHX_HUMAN
B:
[4-371]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
54
PsiBlast_CBE
92.06
64%
-120
- C1 -
1M6W
6
ADHX_HUMAN
B:
[4-371]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
121
Fugue
92.00
64%
-120
- C1 -
1TEH
3
ADHX_HUMAN
A:
[1-373]
AN
E
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
K
I
29
PsiBlast_PDB
91.88
64%
-120
- C1 -
3QJ5
10
ADHX_HUMAN
A:
[5-372]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
55
PsiBlast_CBE
91.84
64%
-121
- C1 -
1M6H
6
ADHX_HUMAN
B:
[4-371]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
36
PsiBlast_PDB
91.83
64%
-119
- C1 -
2FZW
6
ADHX_HUMAN
A:
[4-371]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
L
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
45
PsiBlast_CBE
91.74
64%
-121
- C1 -
4JJI
9
ADHX_ARATH
B:
[6-374]
---
V
I
T
C
K
A
A
V
A
Y
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
I
K
I
L
Y
T
A
L
C
H
T
D
A
Y
-
T
W
-
S
G
K
D
P
E
G
L
F
P
C
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
A
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
S
A
T
G
-
V
----
G
I
M
M
N
D
R
K
S
R
F
S
V
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
T
A
P
L
D
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
N
V
A
I
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
T
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
Y
E
T
A
K
K
F
G
V
N
E
F
V
N
P
K
D
H
D
K
P
I
Q
E
V
I
V
D
L
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
A
A
L
-
E
C
C
-
H
K
G
W
-
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
T
Q
V
P
W
L
V
E
K
Y
M
N
K
E
I
K
V
D
E
Y
I
T
H
N
L
T
L
G
E
I
N
K
A
F
D
L
L
H
E
G
T
C
L
R
C
V
L
--
43
PsiBlast_CBE
91.52
65%
-121
- C1 -
4DL9
6
?
B:
[24-392]
---
V
I
T
C
K
A
A
V
A
W
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
V
K
V
L
Y
T
A
L
C
H
T
D
A
Y
-
T
W
-
S
G
K
D
P
E
G
L
F
P
C
V
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
P
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
A
A
T
G
-
V
----
G
V
M
M
N
D
R
K
S
R
F
S
I
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
V
A
P
L
E
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
I
V
A
V
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
A
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
F
D
R
A
K
N
F
G
V
T
E
F
I
N
P
K
E
H
E
Q
P
I
Q
Q
V
I
V
D
L
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
S
A
L
-
E
C
C
-
H
K
G
W
-
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
S
Q
V
P
S
L
V
D
K
Y
L
K
K
E
I
K
V
D
E
Y
I
T
H
N
M
T
L
A
D
I
N
K
A
F
D
L
M
H
D
G
D
C
L
R
V
V
L
--
48
PsiBlast_CBE
91.50
64%
-122
- C1 -
1MC5
6
ADHX_HUMAN
B:
[5-372]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
35
PsiBlast_PDB
91.44
64%
-118
- C1 -
2FZE
6
ADHX_HUMAN
A:
[4-371]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
44
PsiBlast_CBE
91.26
64%
-121
- C1 -
4L0Q
7
ADHX_ARATH
B:
[6-374]
---
V
I
T
C
K
A
A
V
A
Y
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
I
K
I
L
Y
T
A
L
C
H
T
D
A
Y
-
T
W
-
S
G
K
D
P
E
G
L
F
P
C
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
A
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
S
A
T
G
-
V
----
G
I
M
M
N
D
R
K
S
R
F
S
V
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
T
A
P
L
D
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
N
V
A
I
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
T
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
Y
E
T
A
K
K
F
G
V
N
E
F
V
N
P
K
D
H
D
K
P
I
Q
E
V
I
V
D
L
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
A
A
L
-
E
C
C
-
H
K
G
W
-
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
T
Q
V
P
W
L
V
E
K
Y
M
N
K
E
I
K
V
D
E
Y
I
T
H
N
L
T
L
G
E
I
N
K
A
F
D
L
L
H
E
G
T
A
L
R
A
V
L
--
24
PsiBlast_PDB
91.05
64%
-118
- C1 -
4L0Q
7
ADHX_ARATH
A:
[6-374]
---
V
I
T
C
K
A
A
V
A
Y
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
I
K
I
L
Y
T
A
L
C
H
T
D
A
Y
-
T
W
-
S
G
K
D
P
E
G
L
F
P
C
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
A
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
S
A
T
G
-
V
----
G
I
M
M
N
D
R
K
S
R
F
S
V
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
T
A
P
L
D
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
N
V
A
I
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
T
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
Y
E
T
A
K
K
F
G
V
N
E
F
V
N
P
K
D
H
D
K
P
I
Q
E
V
I
V
D
L
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
A
A
L
-
E
C
C
-
H
K
G
W
-
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
T
Q
V
P
W
L
V
E
K
Y
M
N
K
E
I
K
V
D
E
Y
I
T
H
N
L
T
L
G
E
I
N
K
A
F
D
L
L
H
E
G
T
A
L
R
A
V
L
--
34
PsiBlast_PDB
91.01
64%
-120
- C1 -
1MP0
6
ADHX_HUMAN
A:
[4-371]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
28
PsiBlast_PDB
90.89
64%
-118
- C1 -
1MC5
7
ADHX_HUMAN
A:
[5-372]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
33
PsiBlast_PDB
90.79
64%
-122
- C1 -
1MA0
8
ADHX_HUMAN
A:
[4-371]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
30
PsiBlast_PDB
90.43
64%
-119
- C1 -
1TEH
3
ADHX_HUMAN
A:
[4-371]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
51
PsiBlast_CBE
90.39
64%
-119
- C1 -
1TEH
4
ADHX_HUMAN
B:
[4-371]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
27
PsiBlast_PDB
90.36
64%
-118
- C1 -
4JJI
9
ADHX_ARATH
A:
[6-374]
---
V
I
T
C
K
A
A
V
A
Y
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
I
K
I
L
Y
T
A
L
C
H
T
D
A
Y
-
T
W
-
S
G
K
D
P
E
G
L
F
P
C
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
A
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
S
A
T
G
-
V
----
G
I
M
M
N
D
R
K
S
R
F
S
V
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
T
A
P
L
D
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
N
V
A
I
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
T
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
Y
E
T
A
K
K
F
G
V
N
E
F
V
N
P
K
D
H
D
K
P
I
Q
E
V
I
V
D
L
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
A
A
L
-
E
C
C
-
H
K
G
W
-
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
T
Q
V
P
W
L
V
E
K
Y
M
N
K
E
I
K
V
D
E
Y
I
T
H
N
L
T
L
G
E
I
N
K
A
F
D
L
L
H
E
G
T
C
L
R
C
V
L
--
26
PsiBlast_PDB
90.28
64%
-119
- C1 -
4GL4
11
ADHX_ARATH
A:
[6-374]
---
V
I
T
C
K
A
A
V
A
Y
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
I
K
I
L
Y
T
A
L
C
H
T
D
A
Y
-
T
W
-
S
G
K
D
P
E
G
L
F
P
C
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
A
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
S
A
T
G
-
V
----
G
I
M
M
N
D
R
K
S
R
F
S
V
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
T
A
P
L
D
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
N
V
A
I
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
T
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
Y
E
T
A
K
K
F
G
V
N
E
F
V
N
P
K
D
H
D
K
P
I
Q
E
V
I
V
D
L
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
A
A
L
-
E
C
C
-
H
K
G
W
-
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
T
Q
V
P
W
L
V
E
K
Y
M
N
K
E
I
K
V
D
E
Y
I
T
H
N
L
T
L
G
E
I
N
K
A
F
D
L
L
H
E
G
T
C
L
R
C
V
L
--
32
PsiBlast_PDB
90.04
64%
-120
- C1 -
1M6W
8
ADHX_HUMAN
A:
[4-371]
---
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
-
T
L
-
S
G
A
D
P
E
G
C
F
P
V
I
L
G
H
E
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
-
K
----
G
-
L
M
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
-
E
A
C
-
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
--
25
PsiBlast_PDB
90.04
64%
-119
- C1 -
3UKO
10
ADHX_ARATH
A:
[6-374]
---
V
I
T
C
K
A
A
V
A
Y
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
I
K
I
L
Y
T
A
L
C
H
T
D
A
Y
-
T
W
-
S
G
K
D
P
E
G
L
F
P
C
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
A
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
S
A
T
G
-
V
----
G
I
M
M
N
D
R
K
S
R
F
S
V
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
T
A
P
L
D
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
N
V
A
I
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
T
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
Y
E
T
A
K
K
F
G
V
N
E
F
V
N
P
K
D
H
D
K
P
I
Q
E
V
I
V
D
L
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
A
A
L
-
E
C
C
-
H
K
G
W
-
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
T
Q
V
P
W
L
V
E
K
Y
M
N
K
E
I
K
V
D
E
Y
I
T
H
N
L
T
L
G
E
I
N
K
A
F
D
L
L
H
E
G
T
C
L
R
C
V
L
--
3
HHSearch
89.91
64%
-118
- C1 -
3UKO
10
ADHX_ARATH
A:
[6-376]
---
V
I
T
C
K
A
A
V
A
Y
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
I
K
I
L
Y
T
A
L
C
H
T
D
A
Y
-
T
W
-
S
G
K
D
P
E
G
L
F
P
C
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
A
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
S
A
T
G
V
G
----
I
-
M
M
N
D
R
K
S
R
F
S
V
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
T
A
P
L
D
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
N
V
A
I
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
T
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
Y
E
T
A
K
K
F
G
V
N
E
F
V
N
P
K
D
H
D
K
P
I
Q
E
V
I
V
D
L
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
A
A
L
-
E
C
C
-
H
K
-
G
W
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
T
Q
V
P
W
L
V
E
K
Y
M
N
K
E
I
K
V
D
E
Y
I
T
H
N
L
T
L
G
E
I
N
K
A
F
D
L
L
H
E
G
T
C
L
R
C
V
L
D
T
47
PsiBlast_CBE
89.88
64%
-118
- C1 -
3UKO
10
ADHX_ARATH
B:
[6-374]
---
V
I
T
C
K
A
A
V
A
Y
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
I
K
I
L
Y
T
A
L
C
H
T
D
A
Y
-
T
W
-
S
G
K
D
P
E
G
L
F
P
C
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
A
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
S
A
T
G
-
V
----
G
I
M
M
N
D
R
K
S
R
F
S
V
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
T
A
P
L
D
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
N
V
A
I
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
T
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
Y
E
T
A
K
K
F
G
V
N
E
F
V
N
P
K
D
H
D
K
P
I
Q
E
V
I
V
D
L
T
D
G
-
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
A
A
L
-
E
C
C
-
H
K
G
W
-
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
T
Q
V
P
W
L
V
E
K
Y
M
N
K
E
I
K
V
D
E
Y
I
T
H
N
L
T
L
G
E
I
N
K
A
F
D
L
L
H
E
G
T
C
L
R
C
V
L
--
65
PsiBlast_CBE
89.06
51%
-119
- C1 -
1HSZ
4
ADH1B_HUMAN
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
59
PsiBlast_CBE
89.03
51%
-121
- C1 -
1HDY
6
ADH1B_HUMAN
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
H
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
38
PsiBlast_PDB
88.98
51%
-120
- C1 -
1HDY
4
ADH1B_HUMAN
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
H
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
39
PsiBlast_PDB
88.93
51%
-121
- C1 -
1HDX
6
ADH1B_HUMAN
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
72
PsiBlast_CBE
88.78
50%
-119
- C1 -
1HTB
5
ADH1B_HUMAN
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
C
T
V
L
T
F
70
PsiBlast_CBE
88.75
51%
-119
- C1 -
1HDZ
5
ADH1B_HUMAN
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
G
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
71
PsiBlast_CBE
88.69
51%
-118
- C1 -
1HDZ
4
ADH1B_HUMAN
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
G
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
69
PsiBlast_CBE
88.62
51%
-119
- C1 -
1DEH
4
ADH1B_HUMAN
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
61
PsiBlast_CBE
88.37
51%
-119
- C1 -
1U3V
7
ADH1B_HUMAN
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
68
PsiBlast_CBE
88.30
51%
-119
- C1 -
1DEH
5
ADH1B_HUMAN
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
40
PsiBlast_PDB
88.04
51%
-120
- C1 -
3HUD
3
ADH1B_HUMAN
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
67
PsiBlast_CBE
87.78
51%
-118
- C1 -
1HDX
5
ADH1B_HUMAN
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
64
PsiBlast_CBE
87.48
51%
-117
- C1 -
1U3U
6
ADH1B_HUMAN
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
62
PsiBlast_CBE
87.38
51%
-117
- C1 -
1U3V
6
ADH1B_HUMAN
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
73
PsiBlast_CBE
87.28
50%
-119
- C1 -
1HTB
4
ADH1B_HUMAN
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
C
T
V
L
T
F
63
PsiBlast_CBE
86.98
51%
-119
- C1 -
1U3U
6
ADH1B_HUMAN
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
60
PsiBlast_CBE
86.47
51%
-119
- C1 -
3HUD
3
ADH1B_HUMAN
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
66
PsiBlast_CBE
86.21
51%
-117
- C1 -
1HSZ
3
ADH1B_HUMAN
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
-
V
V
-
S
G
-
N
L
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
-
R
----
G
-
T
L
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
103
PsiBlast_CBE
85.86
48%
-115
- C1 -
2JHG
5
ADH1E_HORSE
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
82
PsiBlast_CBE
85.32
49%
-114
- C1 -
4NFH
7
ADH1E_HORSE
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
89
PsiBlast_CBE
85.21
48%
-116
- C1 -
4XD2
5
ADH1E_HORSE
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
104
PsiBlast_CBE
85.16
48%
-115
- C1 -
2JHG
4
ADH1E_HORSE
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
113
PsiBlast_CBE
85.07
48%
-115
- C1 -
1N92
5
ADH1E_HORSE
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
102
PsiBlast_CBE
84.99
48%
-116
- C1 -
2OHX
5
ADH1E_HORSE
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
91
PsiBlast_CBE
84.96
48%
-115
- C1 -
4DXH
5
ADH1E_HORSE
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
83
PsiBlast_CBE
84.82
49%
-116
- C1 -
4NFH
9
ADH1E_HORSE
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
37
PsiBlast_PDB
84.82
53%
-120
- C1 -
1CDO
3
ADH1_GADMC
A:
[6-372]
---
V
I
K
C
K
A
A
V
A
W
E
A
N
K
P
L
V
I
E
E
I
E
V
D
V
P
H
A
N
E
I
R
I
K
I
I
A
T
G
V
C
H
T
D
L
Y
-
H
L
F
E
G
K
H
K
D
G
-
F
P
V
V
L
G
H
E
G
A
G
I
V
E
S
V
G
P
G
V
T
E
F
Q
P
G
E
K
V
I
P
L
F
I
S
Q
C
G
E
C
R
F
C
Q
S
P
K
T
N
Q
C
V
K
G
W
A
N
E
S
-
P
----
D
-
V
M
S
P
K
E
T
R
F
T
C
K
G
R
K
V
L
Q
F
L
G
T
S
T
F
S
Q
Y
T
V
V
N
Q
I
A
V
A
K
I
D
P
S
A
P
L
D
T
V
C
L
L
G
C
G
V
S
T
G
F
G
A
A
V
N
T
A
K
V
E
P
G
S
T
C
A
V
F
G
L
G
A
V
G
L
A
A
V
M
G
C
H
S
A
G
A
K
R
I
I
A
V
D
L
N
P
D
K
F
E
K
A
K
V
F
G
A
T
D
F
V
N
P
N
D
H
S
E
P
I
S
Q
V
L
S
K
M
T
N
G
-
G
V
D
F
S
L
E
C
V
G
N
V
G
V
M
R
N
A
L
-
E
S
C
-
L
K
G
W
-
G
V
S
V
L
V
G
W
T
D
L
-
H
D
V
A
T
R
P
I
Q
L
I
A
G
R
T
W
K
G
S
M
F
G
G
F
K
G
K
D
G
V
P
K
M
V
K
A
Y
L
D
K
K
V
K
L
D
E
F
I
T
H
R
M
P
L
E
S
V
N
D
A
I
D
L
M
K
H
G
K
C
I
R
T
V
L
--
57
PsiBlast_CBE
84.64
53%
-122
- C1 -
1CDO
3
ADH1_GADMC
B:
[6-372]
---
V
I
K
C
K
A
A
V
A
W
E
A
N
K
P
L
V
I
E
E
I
E
V
D
V
P
H
A
N
E
I
R
I
K
I
I
A
T
G
V
C
H
T
D
L
Y
-
H
L
F
E
G
K
H
K
D
G
-
F
P
V
V
L
G
H
E
G
A
G
I
V
E
S
V
G
P
G
V
T
E
F
Q
P
G
E
K
V
I
P
L
F
I
S
Q
C
G
E
C
R
F
C
Q
S
P
K
T
N
Q
C
V
K
G
W
A
N
E
S
-
P
----
D
-
V
M
S
P
K
E
T
R
F
T
C
K
G
R
K
V
L
Q
F
L
G
T
S
T
F
S
Q
Y
T
V
V
N
Q
I
A
V
A
K
I
D
P
S
A
P
L
D
T
V
C
L
L
G
C
G
V
S
T
G
F
G
A
A
V
N
T
A
K
V
E
P
G
S
T
C
A
V
F
G
L
G
A
V
G
L
A
A
V
M
G
C
H
S
A
G
A
K
R
I
I
A
V
D
L
N
P
D
K
F
E
K
A
K
V
F
G
A
T
D
F
V
N
P
N
D
H
S
E
P
I
S
Q
V
L
S
K
M
T
N
G
-
G
V
D
F
S
L
E
C
V
G
N
V
G
V
M
R
N
A
L
-
E
S
C
-
L
K
G
W
-
G
V
S
V
L
V
G
W
T
D
L
-
H
D
V
A
T
R
P
I
Q
L
I
A
G
R
T
W
K
G
S
M
F
G
G
F
K
G
K
D
G
V
P
K
M
V
K
A
Y
L
D
K
K
V
K
L
D
E
F
I
T
H
R
M
P
L
E
S
V
N
D
A
I
D
L
M
K
H
G
K
C
I
R
T
V
L
--
94
PsiBlast_CBE
84.63
48%
-115
- C1 -
4DWV
9
ADH1E_HORSE
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
99
PsiBlast_CBE
84.57
48%
-116
* C1 *
2OXI
5
ADH1E_HORSE
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
101
PsiBlast_CBE
84.55
48%
-118
- C1 -
2OHX
5
ADH1E_HORSE
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
5
HHSearch
84.14
52%
-120
- C1 -
1CDO
3
ADH1_GADMC
A:
[6-374]
---
V
I
K
C
K
A
A
V
A
W
E
A
N
K
P
L
V
I
E
E
I
E
V
D
V
P
H
A
N
E
I
R
I
K
I
I
A
T
G
V
C
H
T
D
L
Y
H
L
F
-
E
G
K
H
-
K
D
G
F
P
V
V
L
G
H
E
G
A
G
I
V
E
S
V
G
P
G
V
T
E
F
Q
P
G
E
K
V
I
P
L
F
I
S
Q
C
G
E
C
R
F
C
Q
S
P
K
T
N
Q
C
V
K
G
W
A
N
E
S
-
P
----
D
-
V
M
S
P
K
E
T
R
F
T
C
K
G
R
K
V
L
Q
F
L
G
T
S
T
F
S
Q
Y
T
V
V
N
Q
I
A
V
A
K
I
D
P
S
A
P
L
D
T
V
C
L
L
G
C
G
V
S
T
G
F
G
A
A
V
N
T
A
K
V
E
P
G
S
T
C
A
V
F
G
L
G
A
V
G
L
A
A
V
M
G
C
H
S
A
G
A
K
R
I
I
A
V
D
L
N
P
D
K
F
E
K
A
K
V
F
G
A
T
D
F
V
N
P
N
D
H
S
E
P
I
S
Q
V
L
S
K
M
T
N
G
-
G
V
D
F
S
L
E
C
V
G
N
V
G
V
M
R
N
A
L
E
S
C
L
-
K
G
-
W
-
G
V
S
V
L
V
G
W
T
D
L
H
D
-
V
A
T
R
P
I
Q
L
I
A
G
R
T
W
K
G
S
M
F
G
G
F
K
G
K
D
G
V
P
K
M
V
K
A
Y
L
D
K
K
V
K
L
D
E
F
I
T
H
R
M
P
L
E
S
V
N
D
A
I
D
L
M
K
H
G
K
C
I
R
T
V
L
S
L
92
PsiBlast_CBE
84.13
48%
-116
- C1 -
4DXH
8
ADH1E_HORSE
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
93
PsiBlast_CBE
84.10
48%
-113
- C1 -
4DWV
7
ADH1E_HORSE
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
105
PsiBlast_CBE
84.04
48%
-115
- C1 -
2JHF
5
ADH1E_HORSE
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
74
PsiBlast_CBE
84.01
50%
-119
- C1 -
1U3T
4
ADH1A_HUMAN
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
L
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
V
G
I
C
G
T
D
D
H
-
V
V
-
S
G
T
M
V
T
P
-
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
A
I
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
V
S
N
P
-
Q
----
G
-
T
L
Q
D
G
T
S
R
F
T
C
R
R
K
P
I
H
H
F
L
G
I
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
T
G
R
T
W
K
G
A
I
L
G
G
F
K
S
K
E
C
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
I
L
M
F
100
PsiBlast_CBE
83.88
48%
-115
- C1 -
2OXI
5
ADH1E_HORSE
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
112
PsiBlast_CBE
83.79
48%
-115
- C1 -
1N92
5
ADH1E_HORSE
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
90
PsiBlast_CBE
83.79
48%
-116
- C1 -
4XD2
6
ADH1E_HORSE
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
77
PsiBlast_CBE
83.76
50%
-117
- C1 -
1HSO
5
ADH1A_HUMAN
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
L
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
V
G
I
C
G
T
D
D
H
-
V
V
-
S
G
T
M
V
T
P
-
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
A
I
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
V
S
N
P
-
Q
----
G
-
T
L
Q
D
G
T
S
R
F
T
C
R
R
K
P
I
H
H
F
L
G
I
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
T
G
R
T
W
K
G
A
I
L
G
G
F
K
S
K
E
C
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
I
L
M
F
106
PsiBlast_CBE
83.68
48%
-114
- C1 -
2JHF
4
ADH1E_HORSE
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
75
PsiBlast_CBE
83.54
50%
-119
- C1 -
1U3T
5
ADH1A_HUMAN
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
L
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
V
G
I
C
G
T
D
D
H
-
V
V
-
S
G
T
M
V
T
P
-
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
A
I
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
V
S
N
P
-
Q
----
G
-
T
L
Q
D
G
T
S
R
F
T
C
R
R
K
P
I
H
H
F
L
G
I
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
T
G
R
T
W
K
G
A
I
L
G
G
F
K
S
K
E
C
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
I
L
M
F
88
PsiBlast_CBE
82.78
48%
-112
- C1 -
5ADH
4
ADH1E_HORSE
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
76
PsiBlast_CBE
82.78
50%
-114
- C1 -
1HSO
6
ADH1A_HUMAN
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
L
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
V
G
I
C
G
T
D
D
H
-
V
V
-
S
G
T
M
V
T
P
-
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
A
I
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
V
S
N
P
-
Q
----
G
-
T
L
Q
D
G
T
S
R
F
T
C
R
R
K
P
I
H
H
F
L
G
I
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
-
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
T
G
R
T
W
K
G
A
I
L
G
G
F
K
S
K
E
C
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
I
L
M
F
2
HHSearch
79.97
47%
-116
- C1 -
1E3I
4
ADH4_MOUSE
A:
[6-375]
---
V
I
K
C
K
A
A
I
A
W
K
T
G
S
P
L
C
I
E
E
I
E
V
S
P
P
K
A
C
E
V
R
I
Q
V
I
A
T
C
V
C
P
T
D
I
N
-
A
T
-
D
P
K
K
K
-
A
L
F
P
V
V
L
G
H
E
C
A
G
I
V
E
S
V
G
P
G
V
T
N
F
K
P
G
D
K
V
I
P
F
F
A
P
Q
C
K
R
C
K
L
C
L
S
P
L
T
N
L
C
G
K
L
R
N
F
K
Y
-
P
TIDQ
E
-
L
M
E
D
R
T
S
R
F
T
C
K
G
R
S
I
Y
H
F
M
G
V
S
S
F
S
Q
Y
T
V
V
S
E
A
N
L
A
R
V
D
D
E
A
N
L
E
R
V
C
L
I
G
C
G
F
S
S
G
Y
G
A
A
I
N
T
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
C
V
G
L
S
A
I
I
G
C
K
I
A
G
A
S
R
I
I
A
I
D
I
N
G
E
K
F
P
K
A
K
A
L
G
A
T
D
C
L
N
P
R
E
L
D
K
P
V
Q
D
V
I
T
E
L
T
A
G
-
G
V
D
Y
S
L
D
C
A
G
T
A
Q
T
L
K
A
A
V
-
D
C
T
-
V
L
-
G
W
G
S
C
T
V
V
G
A
K
V
D
E
--
M
T
I
P
T
V
D
V
I
L
G
R
S
I
N
G
T
F
F
G
G
W
K
S
V
D
S
V
P
N
L
V
S
D
Y
K
N
K
K
F
D
L
D
L
L
V
T
H
A
L
P
F
E
S
I
N
D
A
I
D
L
M
K
E
G
K
S
I
R
T
I
L
T
-
87
PsiBlast_CBE
79.95
48%
-119
- C1 -
6ADH
4
ADH1E_HORSE
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
6
HHSearch
79.19
47%
-112
- C1 -
2JHF
4
ADH1E_HORSE
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
-
T
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
-
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
Q
E
A
-
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
86
PsiBlast_CBE
78.31
48%
-118
- C1 -
6ADH
4
ADH1E_HORSE
B:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
85
PsiBlast_CBE
74.80
48%
-109
- C1 -
7ADH
24
ADH1E_HORSE
A:
[6-374]
---
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
-
V
V
-
S
G
T
L
V
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
-
R
----
G
-
T
M
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
-
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F