@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3635: (2016-02-19 )
MAKIVDIKGREVLDSRGNPTVEADVILDNGIVGSACAPSGASTGSREALELRDGDKSRYLGKGVLKAVANINGPIRDLLLGKDAADQKALDHAMIELDGTENKAKLGANAILAVSLAAAKAAAQAKGVPLYAHIADLNGTPGQYSMPVPMMNIINGGEHADNNVDIQEFMVQPVGAKNFAEALRMGAEIFHHLKAVLKARGLNTAVGDEGGFAPNLSSNEDALAAIAEAVEKAGYKLGDDVTLALDCASSEFFKDGKYDLEGEGKVFDAAGFADYLAGLTQRYPIISIEDGMDESDWAGWKGLTDKIGAKVQLVGDDLFVTNTKILKEGIEKGIGNSILIKFNQIGSLTETLEAIQMAKAAGYTAVISHRSGETEDSTIADLAVGTAAGQIKTGSLCRSDRVSKYNQLLRIEEQLGAKAPYRGRAEFRG
Atome Classification :
(55 SA)
......-...10........20........30----------........40........50........60........70........80-.--.--.--......90........100.......110.......120.......130.......140-........150.......160.......170.......180.......190----.......200.--..-..--....210.......220.......230.......240.......250.--.--.--.-.-..260------.------.--------.-----.-.....270-----.--.......280----.......290.......300.......310.....-..320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
K
I
V
D-IKG
R
E
V
LDSRGNP
T
V
E
A
D
V
I
L
DNGI----------VGSACAPSGASTGSR
E
A
L
ELRDGDKS
R
Y
L
G
K
G
V
L
K
A
V
A
NING
P
I
R
D
L
LL--G--K--D--A
A
D
Q
K
A
L
D
H
A
M
I
E
LDGTE
N
K
A
KLGA
N
A
I
L
A
V
S
L
A
A
A
K
A
A
AQAKG
V
P
L
Y
A
H
I
ADLNGT-P-GQYSMPV
P
M
M
N
IINGGEHADNNV
D
I
Q
E
F
M
VQPV
G
A
K
N
F
A
E
A
L
R
M
G
A
E
I
F
H
H
----
L
K
A
V
L
K
AR--G--LN-TA--VGDEGGFAPNLSS
N
E
D
A
L
A
A
I
A
E
A
V
E
KAGYKLGD
D
V
T
L
A
L
DCAS
S
E
F
F--K--D--G-K-YDL--------E------G--------E-----G-
K
V
FDA
A
G
------
F
--
A
D
Y
L
A
G
L
T
QR----Y
P
I
I
S
IEDGMDESDWAGWKG
L
T
D
KIG
A
K
V
Q
L
VGD
D
-
L
F
VT
N
T
K
I
L
K
E
G
I
E
KGIG
N
S
I
L
I
K
FNQIG
S
L
T
E
T
L
E
A
I
Q
M
A
K
AAG
Y
T
A
V
I
SHRSGETEDS
T
I
A
D
L
AVGTAAGQIKTGSLC
R
S
D
R
V
S
K
Y
N
Q
L
L
R
I
E
E
Q
LGAKAPYRGRAEFRG---
23
PsiBlast_CBE
96.93
76%
-68
- C1 -
2FYM
2
ENO_ECOLI
F:
[1-429]
-
S
K
I
V
K
-
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
--
D
--
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
I
A
E
L
N
G
T
-
P
-
G
K
Y
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
A
K
--
G
--
M
N
-
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
--
G
-
K
-
Y
V
L
--------
A
------
G
--------
E
-----
G
N
K
A
F
T
S
E
E
------
F
--
T
H
F
L
E
E
L
T
K
Q
----
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
R
K
E
I
K
G
---
22
PsiBlast_CBE
96.72
76%
-72
- C1 -
3H8A
2
ENO_ECOLI
C:
[2-430]
-
S
K
I
V
K
-
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
--
D
--
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
I
A
E
L
N
G
T
-
P
-
G
K
Y
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
A
K
--
G
--
M
N
-
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
--
G
-
K
-
Y
V
L
--------
A
------
G
--------
E
-----
G
N
K
A
F
T
S
E
E
------
F
--
T
H
F
L
E
E
L
T
K
Q
----
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
R
K
E
I
K
G
---
24
PsiBlast_CBE
96.66
76%
-72
- C1 -
2FYM
2
ENO_ECOLI
D:
[1-429]
-
S
K
I
V
K
-
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
--
D
--
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
I
A
E
L
N
G
T
-
P
-
G
K
Y
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
A
K
--
G
--
M
N
-
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
--
G
-
K
-
Y
V
L
--------
A
----------------------N
K
A
F
T
S
E
E
------
F
--
T
H
F
L
E
E
L
T
K
Q
----
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
R
K
E
I
K
G
---
3
PsiBlast_PDB
96.50
76%
-69
- C1 -
2FYM
2
ENO_ECOLI
A:
[1-429]
-
S
K
I
V
K
-
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
--
D
--
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
I
A
E
L
N
G
T
-
P
-
G
K
Y
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
A
K
--
G
--
M
N
-
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
--
G
-
K
-
Y
V
L
--------
A
------
G
--------
E
-----
G
N
K
A
F
T
S
E
E
------
F
--
T
H
F
L
E
E
L
T
K
Q
----
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
R
K
E
I
K
G
---
1
PsiBlast_PDB
96.45
76%
-72
- C1 -
3H8A
1
ENO_ECOLI
A:
[2-430]
-
S
K
I
V
K
-
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
--
D
--
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
I
A
E
L
N
G
T
-
P
-
G
K
Y
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
A
K
--
G
--
M
N
-
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
--
G
-
K
-
Y
V
L
--------
A
------
G
--------
E
-----
G
N
K
A
F
T
S
E
E
------
F
--
T
H
F
L
E
E
L
T
K
Q
----
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
R
K
E
I
K
G
---
112
HHSearch
96.44
76%
-69
* C1 *
2FYM
2
ENO_ECOLI
A:
[1-429]
-
S
K
I
V
K
-
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
--
D
--
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
I
A
E
L
N
G
T
-
P
-
G
K
Y
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
A
K
--
G
--
M
N
-
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
--
G
-
K
-
Y
V
L
--------
A
------
G
--------
E
G----
N
-
K
A
F
T
S
E
E
------
F
--
T
H
F
L
E
E
L
T
K
Q
----
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
R
K
E
I
K
G
---
2
PsiBlast_PDB
95.65
76%
-67
- C1 -
1E9I
1
ENO_ECOLI
A:
[1-429]
-
S
K
I
V
K
-
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
--
D
--
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
I
A
E
L
N
G
T
-
P
-
G
K
Y
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
A
K
--
G
--
M
N
-
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
--
G
-
K
-
Y
V
L
--------
A
------
G
--------
E
-----
G
N
K
A
F
T
S
E
E
------
F
--
T
H
F
L
E
E
L
T
K
Q
----
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
R
K
E
I
K
G
---
21
PsiBlast_CBE
95.31
76%
-69
- C1 -
3H8A
1
ENO_ECOLI
D:
[2-430]
-
S
K
I
V
K
-
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
--
D
--
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
I
A
E
L
N
G
T
-
P
-
G
K
Y
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
A
K
--
G
--
M
N
-
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
--
G
-
K
-
Y
V
L
--------
A
------
G
--------
E
-----
G
N
K
A
F
T
S
E
E
------
F
--
T
H
F
L
E
E
L
T
K
Q
----
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
R
K
E
I
K
G
---
27
PsiBlast_CBE
94.81
76%
-68
- C1 -
1E9I
1
ENO_ECOLI
B:
[1-429]
-
S
K
I
V
K
-
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
--
D
--
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
I
A
E
L
N
G
T
-
P
-
G
K
Y
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
A
K
--
G
--
M
N
-
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
--
G
-
K
-
Y
V
L
--------
A
------
G
--------
E
-----
G
N
K
A
F
T
S
E
E
------
F
--
T
H
F
L
E
E
L
T
K
Q
----
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
R
K
E
I
K
G
---
25
PsiBlast_CBE
94.48
76%
-68
- C1 -
1E9I
3
ENO_ECOLI
D:
[1-429]
-
S
K
I
V
K
-
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
--
D
--
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
I
A
E
L
N
G
T
-
P
-
G
K
Y
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
A
K
--
G
--
M
N
-
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
--
G
-
K
-
Y
V
L
--------
A
------
G
--------
E
-----
G
N
K
A
F
T
S
E
E
------
F
--
T
H
F
L
E
E
L
T
K
Q
----
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
R
K
E
I
K
G
---
26
PsiBlast_CBE
94.43
76%
-66
- C1 -
1E9I
1
ENO_ECOLI
C:
[1-428]
-
S
K
I
V
K
-
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
--
D
--
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
I
A
E
L
N
G
T
-
P
-
G
K
Y
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
A
K
--
G
--
M
N
-
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
-------
D
--
G
-
K
-
Y
V
L
--------
A
------
G
--------
E
-----
G
N
K
A
F
T
S
E
E
------
F
--
T
H
F
L
E
E
L
T
K
Q
----
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
R
K
E
I
K
----
28
PsiBlast_CBE
91.80
67%
-73
- C1 -
4A3R
3
ENO_BACSU
D:
[1-425]
M
P
Y
I
V
D
-
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
A
----------
F
G
R
A
L
V
P
S
G
A
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
A
P
E
L
L
--
G
--
F
--
D
--
V
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
L
G
G
F
N
S
K
------
T
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
F
R
E
A
L
R
M
G
A
Q
I
F
H
S
----
L
K
S
V
L
S
A
K
--
G
--
L
N
-
T
A
--
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
T
I
V
E
A
I
E
K
A
G
F
K
P
G
E
E
V
K
L
A
M
D
A
A
S
S
E
F
Y
NK
E
--
D
--
G
-
K
-
Y
H
L
--------
S
------
G
--------
E
-----
G
-
V
V
K
T
S
A
E
------
M
--
V
D
W
Y
E
E
L
V
S
K
----
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
A
E
T
A
Q
Y
H
G
I
N
S
F
-----
4
PsiBlast_PDB
91.25
67%
-72
- C1 -
4A3R
-
ENO_BACSU
A:
[1-425]
M
P
Y
I
V
D
-
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
A
----------
F
G
R
A
L
V
P
S
G
A
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
A
P
E
L
L
--
G
--
F
--
D
--
V
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
L
G
G
F
N
S
K
------
T
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
F
R
E
A
L
R
M
G
A
Q
I
F
H
S
----
L
K
S
V
L
S
A
K
--
G
--
L
N
-
T
A
--
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
T
I
V
E
A
I
E
K
A
G
F
K
P
G
E
E
V
K
L
A
M
D
A
A
S
S
E
F
Y
NK
E
--
D
--
G
-
K
-
Y
H
L
--------
S
------
G
--------
E
-----
G
-
V
V
K
T
S
A
E
------
M
--
V
D
W
Y
E
E
L
V
S
K
----
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
A
E
T
A
Q
Y
H
G
I
N
S
F
-----
12
PsiBlast_PDB
90.73
60%
-73
- C1 -
3TQP
2
ENO_COXBU
A:
[3-423]
-
A
T
I
T
D
-
I
N
A
H
E
I
L
D
S
R
A
N
P
T
L
E
V
R
V
T
L
S
S
Q
A
----------
Y
G
C
A
A
V
P
S
G
A
---
E
R
E
A
V
E
L
R
D
N
D
L
E
R
Y
G
G
K
G
V
L
Q
A
V
E
N
V
N
G
P
I
R
D
A
L
L
--
G
--
Q
--
D
--
P
R
S
Q
E
E
I
D
R
I
M
I
E
L
D
G
T
E
N
K
A
N
L
G
A
N
A
I
L
G
V
S
L
A
V
A
Y
A
A
A
N
N
A
D
L
P
L
Y
R
Y
---
L
G
G
D
-
G
-
G
P
F
S
M
P
V
P
M
M
N
I
I
N
G
G
----
N
N
L
D
F
Q
E
F
M
I
V
P
V
G
A
P
T
F
A
E
A
L
R
Y
G
A
E
V
F
H
A
----
L
K
K
R
L
V
S
R
--
G
--
L
M
-
S
A
--
V
G
D
E
G
G
F
A
P
D
L
P
N
N
E
A
A
F
E
L
I
L
E
A
I
E
D
A
N
Y
V
P
G
K
D
I
Y
L
A
L
D
A
A
S
S
E
L
Y
--
Q
--
N
--
G
-
R
-
Y
D
F
--------
E
------
N
----------------
N
Q
L
T
S
E
E
------
M
--
I
D
R
L
T
E
W
T
K
K
----
Y
P
V
I
S
I
E
D
G
L
S
E
N
D
W
A
G
W
K
L
L
T
E
R
L
E
N
K
V
Q
L
V
G
D
D
-
I
F
V
T
N
P
D
I
L
E
K
G
I
K
K
N
I
A
N
A
I
L
V
K
L
N
Q
I
G
T
L
T
E
T
L
A
T
V
G
L
A
K
S
N
K
Y
G
V
I
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
D
A
R
Q
I
K
T
G
S
L
C
R
S
D
R
V
A
K
Y
N
R
L
L
Q
I
E
R
E
L
N
D
Q
A
P
Y
A
G
K
E
A
F
-----
111
HHSearch
90.66
61%
-72
- C1 -
3TQP
2
ENO_COXBU
A:
[2-425]
T
A
T
I
T
D
-
I
N
A
H
E
I
L
D
S
R
A
N
P
T
L
E
V
R
V
T
L
S
S
Q
A
----------
Y
G
C
A
A
V
P
S
G
A
---
E
R
E
A
V
E
L
R
D
N
D
L
E
R
Y
G
G
K
G
V
L
Q
A
V
E
N
V
N
G
P
I
R
D
A
L
L
--
G
--
Q
--
D
--
P
R
S
Q
E
E
I
D
R
I
M
I
E
L
D
G
T
E
N
K
A
N
L
G
A
N
A
I
L
G
V
S
L
A
V
A
Y
A
A
A
N
N
A
D
L
P
L
Y
R
Y
L
G
G
D
G
G
-----
P
F
S
M
P
V
P
M
M
N
I
I
N
G
G
----
N
N
L
D
F
Q
E
F
M
I
V
P
V
G
A
P
T
F
A
E
A
L
R
Y
G
A
E
V
F
H
A
----
L
K
K
R
L
V
S
R
--
G
--
L
M
-
S
A
--
V
G
D
E
G
G
F
A
P
D
L
P
N
N
E
A
A
F
E
L
I
L
E
A
I
E
D
A
N
Y
V
P
G
K
D
I
Y
L
A
L
D
A
A
S
S
E
L
Y
--
Q
--
N
--
G
-
R
-
Y
D
F
--------
E
------
N
----------------
N
Q
L
T
S
E
E
------
M
--
I
D
R
L
T
E
W
T
K
K
----
Y
P
V
I
S
I
E
D
G
L
S
E
N
D
W
A
G
W
K
L
L
T
E
R
L
E
N
K
V
Q
L
V
G
D
D
-
I
F
V
T
N
P
D
I
L
E
K
G
I
K
K
N
I
A
N
A
I
L
V
K
L
N
Q
I
G
T
L
T
E
T
L
A
T
V
G
L
A
K
S
N
K
Y
G
V
I
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
D
A
R
Q
I
K
T
G
S
L
C
R
S
D
R
V
A
K
Y
N
R
L
L
Q
I
E
R
E
L
N
D
Q
A
P
Y
A
G
K
E
A
F
L
F
---
6
PsiBlast_PDB
90.03
63%
-72
- C1 -
1IYX
6
ENO_ENTHR
A:
[2-426]
-
S
I
I
T
D
-
V
Y
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
A
R
Y
G
G
K
G
V
T
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
--
D
--
V
R
D
Q
M
A
I
D
K
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
H
Y
L
G
G
F
N
T
K
------
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
A
D
N
S
I
D
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
A
L
R
M
G
A
E
V
F
H
A
----
L
A
A
I
L
K
S
R
--
G
--
L
A
-
T
S
--
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
G
F
E
V
I
I
E
A
I
E
K
A
G
Y
V
P
G
K
D
V
V
L
A
M
D
A
A
S
S
E
F
Y
DK
E
--
K
--
G
-
V
-
Y
V
L
AD------
S
------
G
--------
E
-----
G
E
K
T
T
D
E
--------
M
--
I
K
F
Y
E
E
L
V
S
K
----
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
D
G
F
K
K
L
T
D
V
L
G
D
K
V
Q
L
V
G
D
D
-
L
F
V
T
N
T
Q
K
L
S
E
G
I
E
K
G
I
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
S
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
K
G
L
K
S
F
-----
114
HHSearch
89.95
62%
-68
- C1 -
1W6T
2
ENO_STRPN
A:
[11-441]
M
S
I
I
T
D
-
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
---
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
G
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
--
D
--
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
I
P
L
Y
S
Y
L
G
G
F
N
------
T
K
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
T
F
K
E
A
L
R
Y
G
A
E
I
F
H
A
----
L
K
K
I
L
K
S
R
--
G
--
L
E
-
T
A
--
V
G
D
E
G
G
F
A
P
R
F
E
G
T
E
D
G
V
E
T
I
L
A
A
I
E
A
A
G
Y
V
P
G
K
D
V
F
L
G
F
D
C
A
S
S
E
F
Y
--
D
--
R
--
K
-
V
-
Y
D
Y
--------
T
------
K
FEGE----
G
-----
A
-
A
V
R
T
S
A
E
------
Q
--
I
D
Y
L
E
E
L
V
N
K
----
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
-
F
F
V
T
N
T
D
Y
L
A
R
G
I
Q
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
R
G
L
K
S
F
Y
N
---
30
PsiBlast_CBE
89.75
63%
-70
- C1 -
1IYX
5
ENO_ENTHR
B:
[2-426]
-
S
I
I
T
D
-
V
Y
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
A
R
Y
G
G
K
G
V
T
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
--
D
--
V
R
D
Q
M
A
I
D
K
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
H
Y
L
G
G
F
N
T
K
------
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
A
D
N
S
I
D
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
A
L
R
M
G
A
E
V
F
H
A
----
L
A
A
I
L
K
S
R
--
G
--
L
A
-
T
S
--
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
G
F
E
V
I
I
E
A
I
E
K
A
G
Y
V
P
G
K
D
V
V
L
A
M
D
A
A
S
S
E
F
Y
DK
E
--
K
--
G
-
V
-
Y
V
L
AD------
S
------
G
--------
E
-----
G
E
K
T
T
D
E
--------
M
--
I
K
F
Y
E
E
L
V
S
K
----
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
D
G
F
K
K
L
T
D
V
L
G
D
K
V
Q
L
V
G
D
D
-
L
F
V
T
N
T
Q
K
L
S
E
G
I
E
K
G
I
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
S
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
K
G
L
K
S
F
-----
118
HHSearch
89.61
61%
-69
- C1 -
3UJ2
5
?
A:
[25-449]
Y
L
E
I
E
K
-
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
---
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
--
D
--
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
L
G
G
L
N
------
A
N
R
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
S
K
--
G
--
L
A
-
T
S
--
V
G
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
F
V
L
A
M
D
A
A
S
S
E
W
K
GE
K
--
K
--
G
-
E
-
Y
I
L
--------
P
------
K
--------
C
-----
K
-
R
K
F
A
S
E
E
------
L
--
V
A
H
W
K
S
L
C
E
R
----
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
-----
13
PsiBlast_PDB
89.61
60%
-69
- C1 -
3UJ2
5
?
A:
[27-449]
--
E
I
E
K
-
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
---
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
--
D
--
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
L
G
G
L
N
A
N
------
R
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
S
K
--
G
--
L
A
-
T
S
--
V
G
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
F
V
L
A
M
D
A
A
S
S
E
W
K
GE
K
--
K
--
G
-
E
-
Y
I
L
--------
P
------
K
--------
C
-----
K
-
R
K
F
A
S
E
E
------
L
--
V
A
H
W
K
S
L
C
E
R
----
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
-----
9
PsiBlast_PDB
87.33
61%
-68
- C1 -
4Z17
3
ENO_CHLAA
A:
[1-425]
M
S
T
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
--
D
--
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
L
----
G
G
-
V
-
Y
A
H
V
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
--
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
D
R
--
G
--
F
S
-
T
T
--
V
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
I
V
I
A
L
D
P
A
T
T
E
I
F
--
E
--
D
--
G
-
K
-
Y
H
L
--------
K
------
R
--------
E
-----
G
-
R
S
L
S
S
A
E
------
M
--
V
D
Y
W
V
D
L
V
N
R
----
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
-
F
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
K
----
81
PsiBlast_CBE
86.21
51%
-69
- C1 -
5ENL
2
ENO1_YEAST
A:
[2-433]
---
V
S
K
-
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
--
A
NI
D
--
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
K
T
-
S
P
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
-
Y
D
L
--------
D
FKNPNS
D
--------
K
-----
S
-
K
W
L
T
G
P
Q
------
L
--
A
D
L
Y
H
S
L
M
K
R
----
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
---
76
PsiBlast_CBE
85.84
52%
-68
- C1 -
3QTP
6
ENO1_ENTHI
A:
[8-434]
---
I
Q
K
-
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
----------
F
R
S
-
C
V
P
S
G
A
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
--
N
--
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
L
A
E
L
T
G
H
-
K
--
E
M
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
----
L
K
V
V
I
K
A
K
Y-
G
--
Q
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
T
--
G
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
--
N
--
E
ET
K
-
K
-
Y
D
L
GKKIPADK
K
------
D
--------
P
-----
S
-
L
V
K
D
V
D
G
------
L
--
I
A
E
Y
V
D
Y
G
K
H
----
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
D
D
-
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
-
N
I
P
Y
A
G
K
--------
75
PsiBlast_CBE
85.44
52%
-69
- C1 -
3QTP
6
ENO1_ENTHI
B:
[8-434]
---
I
Q
K
-
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
----------
F
R
S
-
C
V
P
S
G
A
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
--
N
--
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
L
A
E
L
T
G
H
-
K
--
E
M
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
----
L
K
V
V
I
K
A
K
Y-
G
--
Q
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
T
--
G
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
--
N
--
E
ET
K
-
K
-
Y
D
L
GKKIPADK
K
------
D
--------
P
-----
S
-
L
V
K
D
V
D
G
------
L
--
I
A
E
Y
V
D
Y
G
K
H
----
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
D
D
-
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
-
N
I
P
Y
A
G
K
--------
88
PsiBlast_CBE
85.36
51%
-66
- C1 -
2AL1
6
ENO1_YEAST
B:
[2-433]
---
V
S
K
-
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
--
A
NI
D
--
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
K
T
-
S
P
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
-----
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
-
Y
D
L
--------
D
FKNPNS
D
--------
K
-----
S
-
K
W
L
T
G
P
Q
------
L
--
A
D
L
Y
H
S
L
M
K
R
----
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
---
85
PsiBlast_CBE
85.34
51%
-65
- C1 -
1ELS
3
ENO1_YEAST
A:
[2-433]
---
V
S
K
-
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
--
A
NI
D
--
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
K
T
-
S
P
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
-
Y
D
L
--------
D
FKNPNS
D
--------
K
-----
S
-
K
W
L
T
G
P
Q
------
L
--
A
D
L
Y
H
S
L
M
K
R
----
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
---
96
PsiBlast_CBE
85.27
51%
-65
- C1 -
2AL2
5
ENO1_YEAST
B:
[2-433]
---
V
S
K
-
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
-
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
--
A
--
D
ID
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
D
V
P
L
Y
K
H
L
A
D
L
S
K
S
K
T
-
S
P
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
-----
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
-
Y
D
L
--------
D
FKNPNS
D
--------
K
-----
S
-
K
W
L
T
G
P
Q
------
L
--
A
D
L
Y
H
S
L
M
K
R
----
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
---
89
PsiBlast_CBE
85.25
51%
-64
- C1 -
2AL1
3
ENO1_YEAST
A:
[2-433]
---
V
S
K
-
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
--
A
NI
D
--
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
K
T
-
S
P
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
-
Y
D
L
--------
D
FKNPNS
D
--------
K
-----
S
-
K
W
L
T
G
P
Q
------
L
--
A
D
L
Y
H
S
L
M
K
R
----
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
---
91
PsiBlast_CBE
85.17
51%
-65
- C1 -
1ONE
3
ENO1_YEAST
A:
[2-433]
---
V
S
K
-
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
--
A
NI
D
--
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
K
T
-
S
P
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
-
Y
D
L
--------
D
FKNPNS
D
--------
K
-----
S
-
K
W
L
T
G
P
Q
------
L
--
A
D
L
Y
H
S
L
M
K
R
----
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
---
95
PsiBlast_CBE
85.04
51%
-68
- C1 -
1EBG
3
ENO1_YEAST
A:
[2-433]
---
V
S
K
-
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
--
A
NI
D
--
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
K
T
-
S
P
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
-
Y
D
L
--------
D
FKNPNS
D
--------
K
-----
S
-
K
W
L
T
G
P
Q
------
L
--
A
D
L
Y
H
S
L
M
K
R
----
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
---
87
PsiBlast_CBE
85.01
51%
-64
- C1 -
2ONE
3
ENO1_YEAST
A:
[2-433]
---
V
S
K
-
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
--
A
NI
D
--
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
K
T
-
S
P
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
-
Y
D
L
--------
D
FKNPNS
D
--------
K
-----
S
-
K
W
L
T
G
P
Q
------
L
--
A
D
L
Y
H
S
L
M
K
R
----
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
---
117
HHSearch
85.00
52%
-65
- C1 -
2AKZ
6
ENOG_HUMAN
A:
[1-430]
--
S
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
--
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
-
S
--
D
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
--
Y
GK
D
A
-
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
-
Y
D
L
--------
D
------
F
--------
K
SPTDP
S
-
R
Y
I
T
G
D
Q
------
L
--
G
A
L
Y
Q
D
F
V
R
D
----
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
T
-
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
F
R
N
P
---
116
HHSearch
84.84
52%
-60
- C1 -
2AL1
3
ENO1_YEAST
A:
[1-432]
--
A
V
S
K
-
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
-----------
F
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
--
D
--
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
K
T
-
S
P
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
GA
S
A
-
G
N
--
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
--
D
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
-
Y
D
L
--------
D
------
F
KNPNSD--
K
-----
S
-
K
W
L
T
G
P
Q
------
L
--
A
D
L
Y
H
S
L
M
K
R
----
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
--
G
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
----
90
PsiBlast_CBE
84.73
51%
-65
- C1 -
1ONE
3
ENO1_YEAST
B:
[2-433]
---
V
S
K
-
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
--
A
NI
D
--
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
K
T
-
S
P
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
-
Y
D
L
--------
D
FKNPNS
D
--------
K
-----
S
-
K
W
L
T
G
P
Q
------
L
--
A
D
L
Y
H
S
L
M
K
R
----
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
---
63
PsiBlast_CBE
84.69
52%
-67
- C1 -
3UJR
4
ENOG_HUMAN
A:
[2-428]
---
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
--
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
---
S
D
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
-
Y
D
L
--------
D
------
F
--------
K
-----
S
-
P
T
-
D
P
S
R
------
Y
IT
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
----
58
PsiBlast_CBE
84.68
52%
-64
- C1 -
3UCD
3
ENOG_HUMAN
B:
[2-428]
---
I
Q
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
--
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
---
S
D
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
-
Y
D
L
--------
D
------
F
--------
K
-----
S
-
P
T
-
D
P
S
R
------
Y
IT
G
D
Q
L
G
A
L
Y
Q
D
FVRD
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
----
94
PsiBlast_CBE
84.64
51%
-62
- C1 -
1EBG
3
ENO1_YEAST
B:
[2-433]
---
V
S
K
-
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
--
A
NI
D
--
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
K
T
-
S
P
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
-
Y
D
L
--------
D
FKNPNS
D
--------
K
-----
S
-
K
W
L
T
G
P
Q
------
L
--
A
D
L
Y
H
S
L
M
K
R
----
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
---
80
PsiBlast_CBE
84.53
51%
-67
- C1 -
6ENL
2
ENO1_YEAST
A:
[2-433]
---
V
S
K
-
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
--
A
NI
D
--
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
K
T
-
S
P
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
-
Y
D
L
--------
D
FKNPNS
D
--------
K
-----
S
-
K
W
L
T
G
P
Q
------
L
--
A
D
L
Y
H
S
L
M
K
R
----
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
---
61
PsiBlast_CBE
84.46
52%
-64
- C1 -
3UJS
4
ENOG_HUMAN
A:
[2-428]
---
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
--
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
---
S
D
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
-
Y
D
L
--------
D
------
F
--------
K
-----
S
-
P
T
-
D
P
S
R
------
Y
IT
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
----
67
PsiBlast_CBE
84.22
52%
-63
- C1 -
3UJE
4
ENOG_HUMAN
A:
[2-428]
---
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
--
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
---
S
D
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
-
Y
D
L
--------
D
------
F
--------
K
-----
S
-
P
T
-
D
P
S
R
------
Y
IT
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
----
79
PsiBlast_CBE
84.10
51%
-62
- C1 -
7ENL
2
ENO1_YEAST
A:
[2-433]
---
V
S
K
-
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
--
A
NI
D
--
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
K
T
-
S
P
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
-
Y
D
L
--------
D
FKNPNS
D
--------
K
-----
S
-
K
W
L
T
G
P
Q
------
L
--
A
D
L
Y
H
S
L
M
K
R
----
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
---
65
PsiBlast_CBE
84.10
52%
-62
- C1 -
3UJF
3
ENOG_HUMAN
A:
[2-428]
---
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
--
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
---
S
D
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
-
Y
D
L
--------
D
------
F
--------
K
-----
S
-
P
T
-
D
P
S
R
------
Y
IT
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
----
86
PsiBlast_CBE
84.08
51%
-68
- C1 -
2ONE
2
ENO1_YEAST
B:
[2-433]
---
V
S
K
-
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
--
A
NI
D
--
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
K
T
-
S
P
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
-
Y
D
L
--------
D
FKNPNS
D
--------
K
-----
S
-
K
W
L
T
G
P
Q
------
L
--
A
D
L
Y
H
S
L
M
K
R
----
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
---
120
HHSearch
83.88
52%
-68
- C1 -
3QTP
6
ENO1_ENTHI
A:
[5-437]
S
M
S
I
Q
K
-
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
F
R
S
C
V
P
S
GAS
T
G
V
H
E
A
V
E
L
R
-----------
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
--
N
--
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
L
A
E
L
T
G
H
-
K
--
E
M
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
----
L
K
V
V
I
K
A
K
--
Y
GQ
D
A
-
T
N
--
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
--
T
G
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
--
N
EE
T
--
K
-
K
-
Y
D
L
--------
G
------
K
KIPADKKD
P
-----
S
-
L
V
K
D
V
D
G
------
L
--
I
A
E
Y
V
D
Y
G
K
H
----
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
D
D
-
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
-
I
P
Y
A
G
K
N
W
R
-----
19
PsiBlast_PDB
83.88
52%
-62
- C1 -
3UCD
3
ENOG_HUMAN
A:
[2-428]
---
I
Q
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
--
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
---
S
D
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
-
Y
D
L
--------
D
------
F
--------
K
-----
S
-
P
T
-
D
P
S
R
------
Y
IT
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
----
66
PsiBlast_CBE
83.82
52%
-64
- C1 -
3UJE
3
ENOG_HUMAN
B:
[2-428]
---
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
--
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
---
S
D
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
-
Y
D
L
--------
D
------
F
--------
K
-----
S
-
P
T
-
D
P
S
R
------
Y
IT
G
D
Q
L
G
A
L
Y
Q
D
FVRD
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
----
18
PsiBlast_PDB
83.80
52%
-64
- C1 -
3UCC
4
ENOG_HUMAN
A:
[2-428]
---
I
Q
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
--
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
---
S
D
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
-
Y
D
L
--------
D
------
F
--------
K
-----
S
-
P
T
-
D
P
S
R
------
Y
IT
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
----
62
PsiBlast_CBE
83.73
52%
-66
- C1 -
3UJR
3
ENOG_HUMAN
B:
[2-428]
---
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
--
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
---
S
D
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
-
Y
D
L
--------
D
------
F
--------
K
-----
S
-
P
T
-
D
P
S
R
------
Y
IT
G
D
Q
L
G
A
L
Y
Q
D
FVRD
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
----
60
PsiBlast_CBE
83.71
52%
-66
- C1 -
3UJS
3
ENOG_HUMAN
B:
[2-428]
---
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
--
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
---
S
D
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
-
Y
D
L
--------
D
------
F
--------
K
-----
S
-
P
T
-
D
P
S
R
------
Y
IT
G
D
Q
L
G
A
L
Y
Q
D
FVRD
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
----
101
Fugue
83.46
52%
-60
- C1 -
1ONE
3
ENO1_YEAST
A:
[1-436]
--
A
V
S
K
-
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
-----------
V
F
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
--
A
NI
D
--
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
-
K
T
S
P
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
YG
A
--
S
A
-
G
N
--
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
---G
K
-
Y
D
L
--------
D
FKNPNS
D
--------
K
-----
S
-
K
W
L
T
G
P
Q
------
L
--
A
D
L
Y
H
S
L
M
K
R
----
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
--
A
G
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
DKL
36
PsiBlast_CBE
83.39
61%
-68
- C1 -
4Z17
3
ENO_CHLAA
B:
[2-425]
-
S
T
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
--
D
--
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
L
----
G
G
-
V
-
Y
A
H
V
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
-----
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
D
R
--
G
--
F
S
-
T
T
--
V
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
I
V
I
A
L
D
P
A
T
T
E
I
F
--
E
--
D
--
G
-
K
-
Y
H
L
--------
K
------
R
--------
E
-----
G
-
R
S
L
S
S
A
E
------
M
--
V
D
Y
W
V
D
L
V
N
R
----
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
-
F
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
K
----
59
PsiBlast_CBE
83.19
52%
-64
- C1 -
3UCC
3
ENOG_HUMAN
B:
[2-428]
---
I
Q
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
--
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
---
S
D
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
-
Y
D
L
--------
D
------
F
--------
K
-----
S
-
P
T
-
D
P
S
R
------
Y
IT
G
D
Q
L
G
A
L
Y
Q
D
FVRD
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
----
64
PsiBlast_CBE
83.06
52%
-66
- C1 -
3UJF
3
ENOG_HUMAN
B:
[2-428]
---
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
--
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
---
S
D
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
-
Y
D
L
--------
D
------
F
--------
K
-----
S
-
P
T
-
D
P
S
R
------
Y
IT
G
D
Q
L
G
A
L
Y
Q
D
FVRD
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
----
121
HHSearch
80.66
48%
-65
- C1 -
2PTZ
5
?
A:
[3-429]
H
M
T
I
Q
K
-
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
F
R
S
A
V
P
S
G
AS
T
G
V
Y
E
A
C
E
L
R
-----------
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
--
D
--
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
L
A
S
L
A
G
T
-
K
--
E
L
R
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
L
R
G
I
I
K
K
K
Y
G
Q
------
D
A
-
V
N
--
V
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
--
R
G
K
F
A
I
C
M
D
C
A
A
S
E
T
Y
--
D
EK
K
--
Q
-
Q
-
Y
N
L
--------
T
------
F
--------
K
SP
E
--
P
-
T
W
V
T
A
E
Q
------
L
--
R
E
T
Y
C
K
W
A
H
D
----
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
-
L
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
G
F
P
--------
77
PsiBlast_CBE
44.85
50%
22
- C1 -
1PDZ
2
ENO_HOMGA
A:
[5-431]
---
I
T
K
-
V
F
A
R
T
I
F
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
S
K
G
L
----------
F
R
A
A
-
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
Y
H
G
K
S
V
F
N
A
V
K
N
V
N
D
V
I
V
P
E
I
I
K
S
G
--
L
--
K
--
V
T
Q
Q
K
E
C
D
E
F
M
C
K
L
D
G
T
E
N
K
S
S
L
G
A
N
A
I
L
G
V
S
L
A
I
C
K
A
G
A
A
E
L
G
I
P
L
Y
R
H
I
A
N
L
-
A
N
-
Y
-
D
E
V
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
T
G
A
T
S
F
T
E
A
M
R
M
G
T
E
V
Y
H
H
----
L
K
A
V
I
K
A
R
F-
G
--
L
D
A
T
A
--
V
G
D
E
G
G
F
A
P
N
I
L
N
N
K
D
A
L
D
L
I
Q
E
A
I
K
K
A
G
Y
T
--
G
K
I
E
I
G
M
D
V
A
A
S
E
F
Y
--
K
--
Q
--
N
-
N
I
Y
D
L
--------
D
------
F
--------
K
-----
T
-
A
N
N
D
G
S
Q
KIS
G
D
Q
L
--
R
D
M
Y
M
E
F
C
K
D
----
F
P
I
V
S
I
E
D
P
F
D
Q
D
D
W
E
T
W
S
K
M
T
S
--
G
T
T
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
T
T
A
V
E
K
K
A
C
K
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
S
I
D
A
H
L
L
A
K
K
N
G
W
G
T
M
V
S
H
R
S
G
E
T
E
D
C
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
I
L
R
I
E
E
E
L
G
S
G
A
K
F
A
G
K
-
N
F
R
----