@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3646: (2016-02-19 )
MMSTLSYTLGQLAAHVGAEVRGDADLPIQGLATLQEAGPAQLSFLANPQYRKYLPESRAGAVLLTAADADGFAGTALVVANPYLAYASLSHLFDRKPKAAAGIHPTAIVAADAEVDPSASVGAYAVIESGARIGAGVSIGAHCVIGARSVIGEGGWLAPRVTLYHDVTIGARVSIQSGAVIGGEGFGFANEKGVWQKIAQIGGVTIGDDVEIGANTTIDRGALSDTLIGNGVKLDNQIMIAHNVQIGDHTAMAACVGISGSAKIGRHCMLAGGVGLVGHIEICDNVFVTGMTMVTRSITEPGSYSSGTAMQPAAEWKKSAARIRQLDDMARRLQQLEKRLAAVTSSGDASSDA
Atome Classification :
(25 SA)
.........10........20........30........40........50........60......------..70--.-.----.......80........90........-100........110.......120.......130.......140.......150.......160.......170.......180.......190.-.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MM
S
T
L
S
Y
T
L
G
Q
L
A
A
H
VGAEVRGDADLP
I
Q
G
L
A
T
L
Q
EAGPA
Q
L
S
FLAN
P
Q
Y
R
K
YLPESRA
G
A
V
L
L
T
AA------DAD---G-F----A
G
T
A
L
V
VAN
P
Y
L
A
Y
A
S
L
S
H
L
FDRKPKA-A-AGIHP
T
A
I
V
A
ADAEVDPSASV
G
A
Y
A
V
IESGARIGA
G
V
SIG
A
H
C
V
IG
A
R
S
V
IGEGGWL
A
P
R
V
T
L
Y
H
D
V
TI
G
A
R
V
S
IQS
G
A
V
IGGEGFGFANE-K-
G
V
W
Q
K
I
A
Q
IG
G
V
T
IGDD
V
E
IGAN
T
T
IDRGALSDTLIGN
G
V
K
LD
N
Q
I
M
I
A
H
N
V
QIGDH
T
A
M
A
A
C
VGISGSAKIG
R
H
C
M
LAGGV
G
L
V
G
H
I
E
I
C
D
N
V
F
V
T
G
M
T
M
V
T
R
SITEPGSYSSGTAMQ
P
A
A
E
W
K
K
S
A
A
R
I
R
Q
L
D
D
M
A
R
R
L
Q
Q
L
E
K
R
L
A
A
VTSSGDASSDA
72
HHSearch
94.73
100%
-150
- C2 -
3PMO
3
LPXD_PSEAE
A:
[21-359]
-
M
S
T
L
S
Y
T
L
G
Q
L
A
A
H
V
G
A
E
V
R
G
D
A
D
L
P
I
Q
G
L
A
T
L
Q
E
A
G
P
A
Q
L
S
F
L
A
N
P
Q
Y
R
K
Y
L
P
E
S
R
A
G
A
V
L
L
T
A
A
------
D
A
D
---
G
-
F
----
A
G
T
A
L
V
V
A
N
P
Y
L
A
Y
A
S
L
S
H
L
F
D
R
K
P
K
A
-
A
-
A
G
I
H
P
T
A
I
V
A
A
D
A
E
V
D
P
S
A
S
V
G
A
Y
A
V
I
E
S
G
A
R
I
G
A
G
V
S
I
G
A
H
C
V
I
G
A
R
S
V
I
G
E
G
G
W
L
A
P
R
V
T
L
Y
H
D
V
T
I
G
A
R
V
S
I
Q
S
G
A
V
I
G
G
E
G
F
G
F
A
N
E
-
K
-
G
V
W
Q
K
I
A
Q
I
G
G
V
T
I
G
D
D
V
E
I
G
A
N
T
T
I
D
R
G
A
L
S
D
T
L
I
G
N
G
V
K
L
D
N
Q
I
M
I
A
H
N
V
Q
I
G
D
H
T
A
M
A
A
C
V
G
I
S
G
S
A
K
I
G
R
H
C
M
L
A
G
G
V
G
L
V
G
H
I
E
I
C
D
N
V
F
V
T
G
M
T
M
V
T
R
S
I
T
E
P
G
S
Y
S
S
G
T
A
M
Q
P
A
A
E
W
K
K
S
A
A
R
I
R
Q
L
D
D
M
A
R
R
L
Q
Q
L
E
K
R
L
-------------
1
PsiBlast_PDB
94.67
100%
-150
- C2 -
3PMO
3
LPXD_PSEAE
A:
[21-359]
-
M
S
T
L
S
Y
T
L
G
Q
L
A
A
H
V
G
A
E
V
R
G
D
A
D
L
P
I
Q
G
L
A
T
L
Q
E
A
G
P
A
Q
L
S
F
L
A
N
P
Q
Y
R
K
Y
L
P
E
S
R
A
G
A
V
L
L
T
A
A
------
D
A
D
---
G
-
F
----
A
G
T
A
L
V
V
A
N
P
Y
L
A
Y
A
S
L
S
H
L
F
D
R
K
P
K
A
-
A
-
A
G
I
H
P
T
A
I
V
A
A
D
A
E
V
D
P
S
A
S
V
G
A
Y
A
V
I
E
S
G
A
R
I
G
A
G
V
S
I
G
A
H
C
V
I
G
A
R
S
V
I
G
E
G
G
W
L
A
P
R
V
T
L
Y
H
D
V
T
I
G
A
R
V
S
I
Q
S
G
A
V
I
G
G
E
G
F
G
F
A
N
E
-
K
-
G
V
W
Q
K
I
A
Q
I
G
G
V
T
I
G
D
D
V
E
I
G
A
N
T
T
I
D
R
G
A
L
S
D
T
L
I
G
N
G
V
K
L
D
N
Q
I
M
I
A
H
N
V
Q
I
G
D
H
T
A
M
A
A
C
V
G
I
S
G
S
A
K
I
G
R
H
C
M
L
A
G
G
V
G
L
V
G
H
I
E
I
C
D
N
V
F
V
T
G
M
T
M
V
T
R
S
I
T
E
P
G
S
Y
S
S
G
T
A
M
Q
P
A
A
E
W
K
K
S
A
A
R
I
R
Q
L
D
D
M
A
R
R
L
Q
Q
L
E
K
R
L
-------------
22
PsiBlast_CBE
79.86
51%
-149
- C2 -
4IHH
4
LPXD_ECOLI
E:
[10-344]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
-------------
31
PsiBlast_CBE
79.46
51%
-150
- C2 -
4IHF
3
LPXD_ECOLI
F:
[10-344]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
A
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
-------------
27
PsiBlast_CBE
79.38
51%
-150
- C2 -
4IHG
7
LPXD_ECOLI
E:
[10-344]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
-------------
23
PsiBlast_CBE
79.31
51%
-151
- C2 -
4IHH
4
LPXD_ECOLI
D:
[10-344]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
-------------
24
PsiBlast_CBE
79.24
51%
-151
- C2 -
4IHH
5
LPXD_ECOLI
C:
[10-344]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
-------------
2
PsiBlast_PDB
78.68
51%
-149
- C2 -
4IHH
7
LPXD_ECOLI
A:
[10-344]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
-------------
33
PsiBlast_CBE
78.54
51%
-150
- C2 -
4IHF
3
LPXD_ECOLI
D:
[10-344]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
A
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
-------------
26
PsiBlast_CBE
78.44
51%
-150
- C2 -
4IHG
6
LPXD_ECOLI
F:
[10-340]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
-----------------
25
PsiBlast_CBE
78.41
51%
-146
- C2 -
4IHH
5
LPXD_ECOLI
B:
[10-344]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
-------------
4
PsiBlast_PDB
78.37
51%
-148
- C2 -
4IHF
3
LPXD_ECOLI
A:
[10-344]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
A
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
-------------
35
PsiBlast_CBE
78.28
51%
-148
- C2 -
4IHF
3
LPXD_ECOLI
B:
[10-344]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
A
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
-------------
30
PsiBlast_CBE
78.28
51%
-147
- C2 -
4IHG
6
LPXD_ECOLI
B:
[10-341]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
----------------
21
PsiBlast_CBE
78.26
51%
-146
- C2 -
4IHH
4
LPXD_ECOLI
F:
[10-344]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
-------------
29
PsiBlast_CBE
78.24
51%
-150
- C2 -
4IHG
6
LPXD_ECOLI
C:
[10-341]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
----------------
32
PsiBlast_CBE
78.05
51%
-147
- C2 -
4IHF
3
LPXD_ECOLI
E:
[10-344]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
A
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
-------------
34
PsiBlast_CBE
77.89
51%
-148
- C2 -
4IHF
3
LPXD_ECOLI
C:
[10-344]
-----
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
Q
D
------
D
L
P
---
F
-
A
----
K
S
A
A
L
V
V
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
-
A
-
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
-
R
-
G
N
W
V
K
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
A
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
S
G
I
P
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
-------------
5
PsiBlast_PDB
77.60
43%
-154
- C2 -
4E75
-
LPXD_ACIBS
A:
[8-340]
------
Y
R
L
D
E
L
A
H
L
V
K
G
E
L
I
G
E
G
S
L
Q
F
S
N
L
A
S
L
E
N
A
E
V
N
H
L
T
F
V
N
G
E
K
H
L
D
Q
A
K
V
S
R
A
G
A
Y
I
V
T
A
A
LKEHLP
E
K
D
---
N
-
F
--------
I
I
V
D
N
P
Y
L
A
F
A
I
L
T
H
V
F
D
K
K
I
-
S
-
S
-
T
G
I
E
S
T
A
R
I
H
P
S
A
V
I
S
E
T
A
Y
I
G
H
Y
V
V
I
G
E
N
C
V
V
G
D
N
T
V
I
Q
S
H
T
K
L
D
D
N
V
E
V
G
K
D
C
F
I
D
S
Y
V
T
I
T
G
S
S
K
L
R
D
R
V
R
I
H
S
S
T
V
I
G
G
E
G
F
G
F
A
P
Y
-
Q
-
G
K
W
H
R
I
A
Q
L
G
S
V
L
I
G
N
D
V
R
I
G
S
N
C
S
I
D
R
G
A
L
D
N
T
I
L
E
D
G
V
I
I
D
N
L
V
Q
I
A
H
N
V
H
I
G
S
N
T
A
I
A
A
K
C
G
I
A
G
S
T
K
I
G
K
N
C
I
L
A
G
A
C
G
V
A
G
H
L
S
I
A
D
N
V
T
L
T
G
M
S
M
V
T
K
N
I
S
E
A
G
T
Y
S
S
G
T
G
L
F
E
N
N
H
W
K
K
T
I
V
R
L
R
Q
L
A
D
V
P
--
L
T
Q
I
T
K
R
L
-------------
6
PsiBlast_PDB
77.29
43%
-154
- C2 -
4E79
-
LPXD_ACIBS
A:
[8-340]
------
Y
R
L
D
E
L
A
H
L
V
K
G
E
L
I
G
E
G
S
L
Q
F
S
N
L
A
S
L
E
N
A
E
V
N
H
L
T
F
V
N
G
E
K
H
L
D
Q
A
K
V
S
R
A
G
A
Y
I
V
T
A
A
L
K
E
H
L
P
E
K
D
---
N
-
F
--------
I
I
V
D
N
P
Y
L
A
F
A
I
L
T
H
V
F
D
K
K
I
-
S
-
S
-
T
G
I
E
S
T
A
R
I
H
P
S
A
V
I
S
E
T
A
Y
I
G
H
Y
V
V
I
G
E
N
C
V
V
G
D
N
T
V
I
Q
S
H
T
K
L
D
D
N
V
E
V
G
K
D
C
F
I
D
S
Y
V
T
I
T
G
S
S
K
L
R
D
R
V
R
I
H
S
S
T
V
I
G
G
E
G
F
G
F
A
P
Y
-
Q
-
G
K
W
H
R
I
A
Q
L
G
S
V
L
I
G
N
D
V
R
I
G
S
N
C
S
I
D
R
G
A
L
D
N
T
I
L
E
D
G
V
I
I
D
N
L
V
Q
I
A
H
N
V
H
I
G
S
N
T
A
I
A
A
K
C
G
I
A
G
S
T
K
I
G
K
N
C
I
L
A
G
A
C
G
V
A
G
H
L
S
I
A
D
N
V
T
L
T
G
M
S
M
V
T
K
N
I
S
E
A
G
T
Y
S
S
G
T
G
L
F
E
N
N
H
W
K
K
T
I
V
R
L
R
Q
L
A
D
V
P
--
L
T
Q
I
T
K
R
L
-------------
38
PsiBlast_CBE
74.85
37%
-141
- C2 -
2IU9
6
LPXD_CHLTR
C:
[23-362]
---
Q
S
T
Y
S
L
E
Q
L
A
D
F
L
K
V
E
F
Q
G
N
G
A
T
L
L
S
G
V
E
E
I
E
E
A
K
T
A
H
I
T
F
L
D
N
E
K
Y
A
K
H
L
K
S
S
E
A
G
A
I
I
I
S
R
T
------
Q
F
Q
---
K
-
Y
RDLN
K
N
F
L
I
T
S
E
S
P
S
L
V
F
Q
K
C
L
E
L
F
I
T
P
V
D
S
-
G
F
P
G
I
H
P
T
A
V
I
H
P
T
A
I
I
E
D
H
V
C
I
E
P
Y
A
V
V
C
Q
H
A
H
V
G
S
A
C
H
I
G
S
G
S
V
I
G
A
Y
S
T
V
G
E
H
S
Y
I
H
P
R
V
V
I
R
E
R
V
S
I
G
K
R
V
I
I
Q
P
G
A
V
I
G
S
C
G
F
G
Y
V
T
S
-
A
F
G
Q
H
K
H
L
K
H
L
G
K
V
I
I
E
D
D
V
E
I
G
A
N
T
T
I
D
R
G
R
F
K
H
S
V
V
R
E
G
S
K
I
D
N
L
V
Q
I
A
H
Q
V
E
V
G
Q
H
S
M
I
V
A
Q
A
G
I
A
G
S
T
K
I
G
N
H
V
I
I
G
G
Q
A
G
I
T
G
H
I
C
I
A
D
H
V
I
M
M
A
Q
T
G
V
T
K
S
I
T
S
P
G
I
Y
-
G
G
A
P
A
R
P
Y
Q
E
I
H
R
Q
V
A
K
V
R
N
L
P
R
L
E
E
R
I
A
A
L
E
K
---------------
41
PsiBlast_CBE
74.69
37%
-138
- C2 -
2IU8
6
LPXD_CHLTR
B:
[21-362]
-
M
S
Q
S
T
Y
S
L
E
Q
L
A
D
F
L
K
V
E
F
Q
G
N
G
A
T
L
L
S
G
V
E
E
I
E
E
A
K
T
A
H
I
T
F
L
D
N
E
K
Y
A
K
H
L
K
S
S
E
A
G
A
I
I
I
S
R
T
------
Q
F
Q
---
K
-
Y
RDLN
K
N
F
L
I
T
S
E
S
P
S
L
V
F
Q
K
C
L
E
L
F
I
T
P
V
D
S
-
G
F
P
G
I
H
P
T
A
V
I
H
P
T
A
I
I
E
D
H
V
C
I
E
P
Y
A
V
V
C
Q
H
A
H
V
G
S
A
C
H
I
G
S
G
S
V
I
G
A
Y
S
T
V
G
E
H
S
Y
I
H
P
R
V
V
I
R
E
R
V
S
I
G
K
R
V
I
I
Q
P
G
A
V
I
G
S
C
G
F
G
Y
V
T
S
-
A
F
G
Q
H
K
H
L
K
H
L
G
K
V
I
I
E
D
D
V
E
I
G
A
N
T
T
I
D
R
G
R
F
K
H
S
V
V
R
E
G
S
K
I
D
N
L
V
Q
I
A
H
Q
V
E
V
G
Q
H
S
M
I
V
A
Q
A
G
I
A
G
S
T
K
I
G
N
H
V
I
I
G
G
Q
A
G
I
T
G
H
I
C
I
A
D
H
V
I
M
M
A
Q
T
G
V
T
K
S
I
T
S
P
G
I
Y
-
G
G
A
P
A
R
P
Y
Q
E
I
H
R
Q
V
A
K
V
R
N
L
P
R
L
E
E
R
I
A
A
L
E
K
---------------
39
PsiBlast_CBE
74.59
37%
-138
- C2 -
2IU9
7
LPXD_CHLTR
B:
[21-362]
-
M
S
Q
S
T
Y
S
L
E
Q
L
A
D
F
L
K
V
E
F
Q
G
N
G
A
T
L
L
S
G
V
E
E
I
E
E
A
K
T
A
H
I
T
F
L
D
N
E
K
Y
A
K
H
L
K
S
S
E
A
G
A
I
I
I
S
R
T
------
Q
F
Q
---
K
-
Y
RDLN
K
N
F
L
I
T
S
E
S
P
S
L
V
F
Q
K
C
L
E
L
F
I
T
P
V
D
S
-
G
F
P
G
I
H
P
T
A
V
I
H
P
T
A
I
I
E
D
H
V
C
I
E
P
Y
A
V
V
C
Q
H
A
H
V
G
S
A
C
H
I
G
S
G
S
V
I
G
A
Y
S
T
V
G
E
H
S
Y
I
H
P
R
V
V
I
R
E
R
V
S
I
G
K
R
V
I
I
Q
P
G
A
V
I
G
S
C
G
F
G
Y
V
T
S
-
A
F
G
Q
H
K
H
L
K
H
L
G
K
V
I
I
E
D
D
V
E
I
G
A
N
T
T
I
D
R
G
R
F
K
H
S
V
V
R
E
G
S
K
I
D
N
L
V
Q
I
A
H
Q
V
E
V
G
Q
H
S
M
I
V
A
Q
A
G
I
A
G
S
T
K
I
G
N
H
V
I
I
G
G
Q
A
G
I
T
G
H
I
C
I
A
D
H
V
I
M
M
A
Q
T
G
V
T
K
S
I
T
S
P
G
I
Y
-
G
G
A
P
A
R
P
Y
Q
E
I
H
R
Q
V
A
K
V
R
N
L
P
R
L
E
E
R
I
A
A
L
E
K
---------------
40
PsiBlast_CBE
74.28
37%
-141
- C2 -
2IU8
5
LPXD_CHLTR
C:
[23-362]
---
Q
S
T
Y
S
L
E
Q
L
A
D
F
L
K
V
E
F
Q
G
N
G
A
T
L
L
S
G
V
E
E
I
E
E
A
K
T
A
H
I
T
F
L
D
N
E
K
Y
A
K
H
L
K
S
S
E
A
G
A
I
I
I
S
R
T
------
Q
F
Q
---
K
-
Y
RDLN
K
N
F
L
I
T
S
E
S
P
S
L
V
F
Q
K
C
L
E
L
F
I
T
P
V
D
S
-
G
F
P
G
I
H
P
T
A
V
I
H
P
T
A
I
I
E
D
H
V
C
I
E
P
Y
A
V
V
C
Q
H
A
H
V
G
S
A
C
H
I
G
S
G
S
V
I
G
A
Y
S
T
V
G
E
H
S
Y
I
H
P
R
V
V
I
R
E
R
V
S
I
G
K
R
V
I
I
Q
P
G
A
V
I
G
S
C
G
F
G
Y
V
T
S
-
A
F
G
Q
H
K
H
L
K
H
L
G
K
V
I
I
E
D
D
V
E
I
G
A
N
T
T
I
D
R
G
R
F
K
H
S
V
V
R
E
G
S
K
I
D
N
L
V
Q
I
A
H
Q
V
E
V
G
Q
H
S
M
I
V
A
Q
A
G
I
A
G
S
T
K
I
G
N
H
V
I
I
G
G
Q
A
G
I
T
G
H
I
C
I
A
D
H
V
I
M
M
A
Q
T
G
V
T
K
S
I
T
S
P
G
I
Y
-
G
G
A
P
A
R
P
Y
Q
E
I
H
R
Q
V
A
K
V
R
N
L
P
R
L
E
E
R
I
A
A
L
E
K
---------------
73
HHSearch
73.23
37%
-139
- C2 -
2IU8
9
LPXD_CHLTR
A:
[21-366]
-
M
S
Q
S
T
Y
S
L
E
Q
L
A
D
F
L
K
V
E
F
Q
G
N
G
A
T
L
L
S
G
V
E
E
I
E
E
A
K
T
A
H
I
T
F
L
D
N
E
K
Y
A
K
H
L
K
S
S
E
A
G
A
I
I
I
S
R
T
------
Q
F
Q
K
Y
R
D
L
N
----
K
N
F
L
I
T
S
E
S
P
S
L
V
F
Q
K
C
L
E
L
F
I
T
P
V
D
S
G
F
-
P
G
I
H
P
T
A
V
I
H
P
T
A
I
I
E
D
H
V
C
I
E
P
Y
A
V
V
C
Q
H
A
H
V
G
S
A
C
H
I
G
S
G
S
V
I
G
A
Y
S
T
V
G
E
H
S
Y
I
H
P
R
V
V
I
R
E
R
V
S
I
G
K
R
V
I
I
Q
P
G
A
V
I
G
S
C
G
F
G
Y
V
T
S
A
F
-
G
Q
H
K
H
L
K
H
L
G
K
V
I
I
E
D
D
V
E
I
G
A
N
T
T
I
D
R
G
R
F
K
H
S
V
V
R
E
G
S
K
I
D
N
L
V
Q
I
A
H
Q
V
E
V
G
Q
H
S
M
I
V
A
Q
A
G
I
A
G
S
T
K
I
G
N
H
V
I
I
G
G
Q
A
G
I
T
G
H
I
C
I
A
D
H
V
I
M
M
A
Q
T
G
V
T
K
S
I
T
S
P
G
I
Y
G
-
G
A
P
A
R
P
Y
Q
E
I
H
R
Q
V
A
K
V
R
N
L
P
R
L
E
E
R
I
A
A
L
E
K
L
V
Q
K
-----------