@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3650: (2016-02-19 )
MSRPQRISVLGATGSIGLSTLDVVQRHPDRYEAFALTGFSRLAELEALCLRHRPVYAVVPEQAAAIALQGSLAAAGIRTRVLFGEQALCEVASAPEVDMVMAAIVGAAGLPSTLAAVEAGKRVLLANKEALVMSGALFMQAVKRSGAVLLPIDSEHNAIFQSLPRNYADGLERVGVRRILLTASGGPFRETPLEQLASVTPEQACAHPNWSMGRKISVDSASMMNKGLELIEACWLFDAQPSQVEVVIHPQSVIHSMVDYVDGSVIAQLGNPDMRTPISYAMAWPERIDSGVSPLDMFAVGRLDFQRPDEQRFPCLRLASQAAETGGSAPAMLNAANEVAVAAFLERHIRFSDIAVIIEDVLNREAVTAVESLDQVLAADRRARSVAGQWLTRHAG
Atome Classification :
(72 SA)
.........10........20...---.....30........40....---------....50........60........70.......-.80........90........100.......110.......120.......130.......140.-......150.......160...------..--.-------.--170---.....-....180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360---......--.-370-........380.......390....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSRP
Q
R
I
S
V
L
GATGSI
G
L
S
T
L
D
V
V
---
Q
RHP
D
R
Y
E
A
F
A
L
T
G
F
S
R
L
A
E
L
---------
E
A
L
C
L
RHR
P
V
Y
A
VVPEQ
A
A
A
I
A
LQGS
L
A
AAG
I
R
-
T
R
V
L
FG
E
Q
A
L
C
E
VASAP
E
V
D
M
V
M
A
A
I
VGAAGL
P
S
T
L
A
A
V
EAG
K
R
V
L
L
ANKE
A
L
V
M
S
G
A
L
F
M
Q
A
V
K
-RS
G
A
V
L
L
P
IDSE
H
N
A
I
F
Q
SL
P
R
------
N
Y
--
A
-------
D
--
G
-----
L
E
R
VG-
V
R
R
I
L
L
TASGGPFRE
T
P
L
E
Q
L
A
SV
T
P
E
Q
ACAHPNWSMG
R
K
I
SV
D
S
A
S
M
M
N
K
G
L
E
L
I
E
A
C
W
LFDAQP
S
Q
V
E
V
V
IH
P
Q
S
V
I
H
S
M
V
D
YV
D
G
S
V
I
A
QLGNPDMRT
P
I
S
Y
A
M
A
W
P
E
R
IDSGVS
P
L
D
M
F
A
VGRLDFQRPDEQR
F
P
C
L
R
L
A
S
Q
A
A
ETGGSA
P
A
M
L
N
A
A
N
E
V
A
V
A
A
F
L
E
RHI
R
F
S
D
I
A
V
I
I
E
D
V
L---N
R
E
A
V
T
--
A
-
V
E
--
S
L
D
Q
V
L
A
A
D
R
R
A
R
S
V
A
G
Q
W
L
T
RHAG
10
PsiBlast_PDB
97.26
57%
-115
- C1 -
3R0I
2
DXR_ECOLI
A:
[14-409]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
L
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
-----
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
15
PsiBlast_PDB
97.13
57%
-117
- C1 -
3IIE
2
DXR_YERPY
A:
[5-398]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
N
S
T
L
S
V
V
---
R
A
N
P
E
L
F
K
V
T
A
L
V
A
G
R
N
V
R
E
M
---------
A
Q
Q
C
L
E
F
S
P
R
Y
A
A
M
S
D
E
H
S
A
K
S
L
R
L
L
L
A
E
Q
G
S
D
-
T
E
V
Y
S
G
E
T
A
A
C
E
L
A
A
L
D
D
V
D
Q
V
M
A
A
I
V
G
I
A
G
L
P
S
T
L
A
A
I
R
A
G
K
Q
V
L
L
A
N
K
E
S
L
I
T
C
G
K
L
F
M
D
E
V
K
-
R
S
R
A
Q
L
L
P
I
D
S
E
H
N
A
I
F
Q
S
L
P
E
------
R
I
--
Q
R
Q
LGY--
S
--
S
-----
L
N
E
N
G
-
V
S
R
I
I
L
T
G
S
G
G
P
F
R
E
T
P
L
S
Q
F
S
D
V
T
P
D
Q
A
---------
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
E
Q
I
E
V
V
L
H
P
Q
S
V
I
H
S
M
V
R
Y
H
D
G
S
I
L
A
Q
M
G
T
P
D
M
R
T
P
I
A
H
A
M
A
Y
P
M
R
V
S
S
G
V
A
P
L
D
F
C
K
V
G
A
L
T
F
T
T
P
D
Y
Q
R
Y
P
C
L
K
L
A
I
D
A
C
N
A
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
S
V
M
A
F
L
D
S
K
I
R
F
T
D
I
E
V
I
N
R
T
V
V
---
E
G
L
L
L
S
--
E
-
P
T
--
S
V
E
E
V
L
V
I
D
R
K
A
R
D
V
A
A
Q
V
I
A
K
---
4
PsiBlast_PDB
97.06
57%
-111
- C1 -
1T1R
2
DXR_ECOLI
A:
[2-397]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
L
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
32
PsiBlast_CBE
96.72
57%
-119
- C1 -
3IIE
2
DXR_YERPY
B:
[5-398]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
N
S
T
L
S
V
V
---
R
A
N
P
E
L
F
K
V
T
A
L
V
A
G
R
N
V
R
E
M
---------
A
Q
Q
C
L
E
F
S
P
R
Y
A
A
M
S
D
E
H
S
A
K
S
L
R
L
L
L
A
E
Q
G
S
D
-
T
E
V
Y
S
G
E
T
A
A
C
E
L
A
A
L
D
D
V
D
Q
V
M
A
A
I
V
G
I
A
G
L
P
S
T
L
A
A
I
R
A
G
K
Q
V
L
L
A
N
K
E
S
L
I
T
C
G
K
L
F
M
D
E
V
K
-
R
S
R
A
Q
L
L
P
I
D
S
E
H
N
A
I
F
Q
S
L
P
E
------
R
I
--
Q
R
Q
LGY--
S
--
S
-----
L
N
E
N
G
-
V
S
R
I
I
L
T
G
S
G
G
P
F
R
E
T
P
L
S
Q
F
S
D
V
T
P
D
Q
A
C
A
------
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
E
Q
I
E
V
V
L
H
P
Q
S
V
I
H
S
M
V
R
Y
H
D
G
S
I
L
A
Q
M
G
T
P
D
M
R
T
P
I
A
H
A
M
A
Y
P
M
R
V
S
S
G
V
A
P
L
D
F
C
K
V
G
A
L
T
F
T
T
P
D
Y
Q
R
Y
P
C
L
K
L
A
I
D
A
C
N
A
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
S
V
M
A
F
L
D
S
K
I
R
F
T
D
I
E
V
I
N
R
T
V
V
---
E
G
L
L
L
S
--
E
-
P
T
--
S
V
E
E
V
L
V
I
D
R
K
A
R
D
V
A
A
Q
V
I
A
K
---
21
PsiBlast_CBE
96.60
57%
-117
- C1 -
4ZN6
2
DXR_ACIB3
B:
[11-406]
----
Q
S
V
C
I
L
G
V
T
G
S
I
G
R
S
T
L
K
I
L
---
G
Q
H
P
D
K
Y
S
V
F
A
V
S
A
H
S
R
I
S
E
L
---------
V
E
I
C
K
Q
F
R
P
K
V
V
V
V
P
E
Q
K
I
A
-
E
L
K
T
L
F
A
Q
Q
N
I
S
D
I
D
V
L
A
G
Q
E
G
L
V
D
I
A
S
H
T
D
V
D
I
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
V
K
A
G
K
R
V
L
L
A
N
K
E
A
L
V
M
S
G
E
I
M
M
Q
A
A
R
-
D
H
Q
A
L
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
H
------
N
Y
LQ
A
-------
D
RT
G
-----
Q
P
Q
L
G
-
V
S
K
I
L
L
T
A
S
G
G
P
F
L
N
H
S
L
E
Q
L
V
H
V
T
P
Q
Q
A
---------
Q
K
I
S
V
D
S
A
T
L
M
N
K
G
L
E
L
I
E
A
C
H
L
F
S
I
S
E
H
F
V
T
V
V
V
H
P
Q
S
I
I
H
S
M
V
Q
Y
V
D
G
S
T
L
A
Q
M
G
N
P
D
M
C
T
P
I
A
H
A
L
A
W
P
E
R
L
Q
T
N
V
P
A
L
D
L
F
E
Y
S
Q
L
N
F
Q
A
P
D
T
Q
K
F
P
A
L
N
L
A
R
Q
A
M
R
A
G
G
L
A
P
T
I
L
N
A
A
N
E
I
A
V
E
A
F
L
M
E
R
I
G
F
T
S
I
P
Q
V
V
E
H
T
L
---
E
K
L
E
N
A
--
A
-
A
E
--
S
I
E
C
I
L
D
K
D
K
V
A
R
S
V
A
Q
Q
Y
I
S
S
I
G
G
29
PsiBlast_CBE
96.36
57%
-111
- C1 -
3ANM
2
DXR_ECOLI
B:
[12-407]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
PIQHNL
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
5
PsiBlast_PDB
96.18
57%
-112
- C1 -
1T1S
3
DXR_ECOLI
A:
[2-397]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
L
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
27
PsiBlast_CBE
96.13
57%
-115
- C1 -
3R0I
2
DXR_ECOLI
B:
[14-409]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
PIQHNL
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
-----
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
1
PsiBlast_PDB
96.12
57%
-115
- C1 -
4ZN6
4
DXR_ACIB3
A:
[11-406]
----
Q
S
V
C
I
L
G
V
T
G
S
I
G
R
S
T
L
K
I
L
---
G
Q
H
P
D
K
Y
S
V
F
A
V
S
A
H
S
R
I
S
E
L
---------
V
E
I
C
K
Q
F
R
P
K
V
V
V
V
P
E
Q
K
I
A
-
E
L
K
T
L
F
A
Q
Q
N
I
S
D
I
D
V
L
A
G
Q
E
G
L
V
D
I
A
S
H
T
D
V
D
I
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
V
K
A
G
K
R
V
L
L
A
N
K
E
A
L
V
M
S
G
E
I
M
M
Q
A
A
R
-
D
H
Q
A
L
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
H
------
N
Y
LQ
A
-------
D
RT
G
-----
Q
P
Q
L
G
-
V
S
K
I
L
L
T
A
S
G
G
P
F
L
N
H
S
L
E
Q
L
V
H
V
T
P
Q
Q
A
C
K
-----
M
G
Q
K
I
S
V
D
S
A
T
L
M
N
K
G
L
E
L
I
E
A
C
H
L
F
S
I
S
E
H
F
V
T
V
V
V
H
P
Q
S
I
I
H
S
M
V
Q
Y
V
D
G
S
T
L
A
Q
M
G
N
P
D
M
C
T
P
I
A
H
A
L
A
W
P
E
R
L
Q
T
N
V
P
A
L
D
L
F
E
Y
S
Q
L
N
F
Q
A
P
D
T
Q
K
F
P
A
L
N
L
A
R
Q
A
M
R
A
G
G
L
A
P
T
I
L
N
A
A
N
E
I
A
V
E
A
F
L
M
E
R
I
G
F
T
S
I
P
Q
V
V
E
H
T
L
---
E
K
L
E
N
A
--
A
-
A
E
--
S
I
E
C
I
L
D
K
D
K
V
A
R
S
V
A
Q
Q
Y
I
S
S
I
G
G
24
PsiBlast_CBE
96.10
57%
-109
- C1 -
1T1R
2
DXR_ECOLI
B:
[2-397]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
PIQHNL
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
23
PsiBlast_CBE
96.04
57%
-109
- C1 -
1T1S
2
DXR_ECOLI
B:
[2-397]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
PIQHNL
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
11
PsiBlast_PDB
95.77
57%
-110
- C1 -
3ANL
2
DXR_ECOLI
A:
[12-407]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
L
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
13
PsiBlast_PDB
95.61
57%
-110
- C1 -
3ANN
2
DXR_ECOLI
A:
[12-407]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
L
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
17
PsiBlast_PDB
95.12
55%
-110
- C1 -
1JVS
2
DXR_ECOLI
A:
[2-397]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
L
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
14
PsiBlast_PDB
95.10
57%
-109
- C1 -
2EGH
3
DXR_ECOLI
A:
[12-407]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
L
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
111
HHSearch
94.83
58%
-106
- C1 -
1Q0Q
2
DXR_ECOLI
A:
[9-406]
---
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
------
P
I
--
Q
-------
H
--
N
LGYAD
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
30
PsiBlast_CBE
94.77
57%
-109
- C1 -
3ANL
2
DXR_ECOLI
B:
[12-407]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
PIQHNL
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
31
PsiBlast_CBE
94.64
57%
-110
- C1 -
2EGH
3
DXR_ECOLI
B:
[12-407]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
PIQHNL
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
28
PsiBlast_CBE
94.63
57%
-109
- C1 -
3ANN
2
DXR_ECOLI
B:
[12-407]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
PIQHNL
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
22
PsiBlast_CBE
94.61
57%
-109
- C1 -
1Q0Q
2
DXR_ECOLI
B:
[10-405]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
PIQHNL
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
12
PsiBlast_PDB
94.55
57%
-108
- C1 -
3ANM
2
DXR_ECOLI
A:
[12-407]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
L
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
9
PsiBlast_PDB
93.22
57%
-111
- C1 -
1ONP
2
DXR_ECOLI
A:
[2-397]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
L
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
3
PsiBlast_PDB
93.19
57%
-106
- C1 -
1Q0Q
2
DXR_ECOLI
A:
[10-405]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
L
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
2
PsiBlast_PDB
92.76
57%
-104
- C1 -
1Q0L
2
DXR_ECOLI
A:
[10-405]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
L
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
25
PsiBlast_CBE
92.60
57%
-109
- C1 -
1ONP
2
DXR_ECOLI
B:
[2-397]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
PIQHNL
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
16
PsiBlast_PDB
92.38
55%
-106
- C1 -
1Q0H
3
DXR_ECOLI
A:
[10-405]
----
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
---
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
---------
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
-
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
L
G
Y
--
A
-------
D
--------
L
E
Q
N
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
---
E
K
M
D
M
R
--
E
-
P
Q
--
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-
47
PsiBlast_CBE
82.53
34%
-115
- C1 -
3AU8
2
DXR_PLAFX
B:
[77-484]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
FLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
L
K
TKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
---
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
---
52
PsiBlast_CBE
80.89
34%
-108
- C1 -
4Y6R
3
DXR_PLAF7
B:
[11-419]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
REC
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
YEQAREFLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
LKTKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
ESF
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
50
PsiBlast_CBE
80.89
34%
-107
- C1 -
4Y6S
2
DXR_PLAF7
B:
[11-419]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
REC
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
YEQAREFLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
LKTKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
ESF
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
51
PsiBlast_CBE
80.86
34%
-110
- C1 -
4Y6S
2
DXR_PLAF7
A:
[11-419]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
FLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
L
K
TKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
57
PsiBlast_CBE
80.85
34%
-110
- C1 -
4Y67
2
DXR_PLAF7
A:
[11-419]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
FLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
L
K
TKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
43
PsiBlast_CBE
80.73
34%
-108
- C1 -
3WQQ
4
DXR_PLAFX
A:
[77-485]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
FLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
L
K
TKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
20
PsiBlast_PDB
80.27
34%
-107
- C1 -
3AU9
4
DXR_PLAFX
A:
[77-485]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
FLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
L
K
TKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
53
PsiBlast_CBE
80.20
34%
-109
- C1 -
4Y6R
3
DXR_PLAF7
A:
[11-419]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
FLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
L
K
TKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
54
PsiBlast_CBE
80.05
34%
-106
- C1 -
4Y6P
4
DXR_PLAF7
B:
[11-419]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
REC
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
YEQAREFLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
LKTKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
ESF
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
56
PsiBlast_CBE
79.94
34%
-108
- C1 -
4Y67
2
DXR_PLAF7
B:
[11-419]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
REC
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
YEQAREFLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
LKTKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
ESF
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
59
PsiBlast_CBE
79.90
34%
-108
- C1 -
4GAE
7
DXR_PLAFX
A:
[14-423]
--
K
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
FLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
I
K
TKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
55
PsiBlast_CBE
79.89
34%
-105
- C1 -
4Y6P
3
DXR_PLAF7
A:
[11-419]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
FLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
L
K
TKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
49
PsiBlast_CBE
79.67
34%
-109
- C1 -
4KP7
3
DXR_PLAFX
A:
[16-424]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
FLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
L
K
TKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
48
PsiBlast_CBE
79.47
34%
-112
- C1 -
4KP7
2
DXR_PLAFX
B:
[16-423]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
FLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
L
K
TKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
------
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
---
44
PsiBlast_CBE
79.31
34%
-105
- C1 -
3AUA
5
DXR_PLAFX
B:
[77-485]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
REC
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
YEQAREFLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
LKTKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
ESF
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
42
PsiBlast_CBE
79.27
34%
-105
- C1 -
3WQQ
5
DXR_PLAFX
B:
[77-485]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
REC
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
YEQAREFLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
LKTKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
ESF
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
41
PsiBlast_CBE
79.13
34%
-106
- C1 -
3WQR
4
DXR_PLAFX
A:
[77-485]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
FLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
L
K
TKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
45
PsiBlast_CBE
79.02
34%
-103
- C1 -
3AUA
4
DXR_PLAFX
A:
[77-485]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
FLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
L
K
TKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
39
PsiBlast_CBE
79.00
34%
-107
- C1 -
3WQS
3
DXR_PLAFX
B:
[77-485]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
REC
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
YEQAREFLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
LKTKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
ESF
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
40
PsiBlast_CBE
78.99
34%
-105
- C1 -
3WQR
5
DXR_PLAFX
B:
[77-485]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
REC
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
YEQAREFLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
LKTKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
ESF
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
46
PsiBlast_CBE
78.66
34%
-103
- C1 -
3AU9
5
DXR_PLAFX
B:
[77-485]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
REC
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
YEQAREFLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
LKTKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
ESF
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
58
PsiBlast_CBE
78.10
34%
-107
- C1 -
4GAE
9
DXR_PLAFX
B:
[15-423]
---
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
FLP
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
L
V
K
N
I
K
--------
D
Y
K
-
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
------
N
K
--
V
I
K
TKCLQ
D
--
N
-----
F
S
K
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
EN
S
-
E
D
--
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
--
60
PsiBlast_CBE
77.43
44%
-109
- C1 -
4AIC
3
DXR_MYCTU
B:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
97
PsiBlast_CBE
77.19
43%
-109
- C1 -
2JCX
2
DXR_MYCTU
B:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
N
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
80
PsiBlast_CBE
77.16
44%
-107
- C1 -
2JCV
2
DXR_MYCTU
B:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
64
PsiBlast_CBE
76.06
44%
-105
- C1 -
3RAS
5
DXR_MYCTU
B:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
91
PsiBlast_CBE
75.96
44%
-106
- C1 -
4RCV
3
?
B:
[29-394]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
--
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
62
PsiBlast_CBE
75.90
44%
-103
- C1 -
4A03
3
DXR_MYCTU
B:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
68
PsiBlast_CBE
75.46
44%
-105
- C1 -
2Y1F
3
DXR_MYCTU
B:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
94
PsiBlast_CBE
75.04
43%
-104
- C1 -
2JD0
3
DXR_MYCTU
A:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
N
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
63
PsiBlast_CBE
74.87
44%
-103
- C1 -
4A03
4
DXR_MYCTU
A:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
79
PsiBlast_CBE
74.86
44%
-101
- C1 -
2JD1
4
DXR_MYCTU
A:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
98
PsiBlast_CBE
74.84
43%
-103
- C1 -
2JCX
3
DXR_MYCTU
A:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
N
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
67
PsiBlast_CBE
74.62
44%
-104
- C1 -
2Y1G
4
DXR_MYCTU
A:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
-----
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
61
PsiBlast_CBE
74.49
44%
-103
- C1 -
4AIC
4
DXR_MYCTU
A:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
90
PsiBlast_CBE
73.97
44%
-103
- C1 -
3ZHX
2
DXR_MYCTU
A:
[22-387]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
-
A
-
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
-------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
69
PsiBlast_CBE
73.88
44%
-104
- C1 -
2Y1F
4
DXR_MYCTU
A:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
------
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
65
PsiBlast_CBE
73.87
44%
-106
- C1 -
3RAS
4
DXR_MYCTU
A:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
81
PsiBlast_CBE
73.83
44%
-100
- C1 -
2JCV
3
DXR_MYCTU
A:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
92
PsiBlast_CBE
73.47
44%
-105
- C1 -
4RCV
4
?
A:
[29-394]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
73
PsiBlast_CBE
73.17
44%
-110
- C1 -
2Y1D
2
DXR_MYCTU
A:
[23-388]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
-----------
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
--
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
----------
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
87
PsiBlast_CBE
72.78
44%
-102
- C1 -
3ZHY
3
DXR_MYCTU
B:
[22-387]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
-
A
-
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
86
PsiBlast_CBE
72.53
44%
-105
- C1 -
3ZHZ
1
DXR_MYCTU
A:
[22-387]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
--------
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
-
A
-
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
-------
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
88
PsiBlast_CBE
72.40
44%
-102
- C1 -
3ZHY
3
DXR_MYCTU
A:
[22-387]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
-
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
-
A
-
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
-----
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
85
PsiBlast_CBE
71.65
44%
-107
- C1 -
3ZI0
1
DXR_MYCTU
A:
[22-387]
-----
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
---
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
--
A
H
L
---------
D
T
L
-
L
R
Q
R
A
Q
T
G
V
T
-----
N
I
A
V
------------
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
-
A
-
R
P
G
Q
I
V
-
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
G
------
G
T
--
P
-------
D
--
E
-----------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
---
H
A
A
D
Q
W
--
A
-
V
E
PA
T
V
D
D
V
L
D
A
Q
R
W
A
R
------------
114
HHSearch
71.48
35%
-104
- C1 -
3A06
4
DXR_THEMA
A:
[3-372]
---
E
R
T
L
V
I
L
G
A
T
G
S
I
G
T
Q
T
L
D
V
L
---
K
K
V
-
K
G
I
R
L
I
G
I
S
F
H
S
N
L
E
L
A
---------
F
K
I
V
K
E
F
N
V
K
N
V
A
I
T
G
D
V
E
F
E
D
S
S
----------
I
N
V
W
K
G
S
H
S
I
E
E
M
L
E
A
L
K
P
D
I
T
M
V
A
V
S
G
F
S
G
L
R
A
V
L
A
S
L
E
H
S
K
R
V
C
L
A
N
K
E
S
L
V
C
G
G
F
L
V
K
K
K
L
K
-
E
K
G
T
E
L
I
P
V
D
S
E
H
S
A
I
F
Q
V
M
E
P
-------------------------------
E
-
V
E
K
V
V
L
T
A
S
G
G
A
L
R
D
W
K
I
S
K
I
D
R
A
R
P
E
D
V
L
K
H
P
V
W
N
M
G
A
R
I
T
V
D
S
A
T
M
V
N
K
A
F
E
V
L
E
A
M
E
L
F
E
L
P
F
E
K
I
E
V
K
I
H
R
E
G
L
V
H
G
A
V
V
L
P
D
G
N
V
K
M
V
V
S
P
P
D
M
R
I
P
I
S
Y
A
L
F
Y
P
R
R
V
A
L
--
E
P
-
F
F
L
R
T
I
S
L
S
F
E
D
P
D
P
E
K
Y
P
A
F
F
L
L
K
E
I
K
D
-
S
Y
A
L
R
T
A
F
N
A
A
D
E
V
A
V
E
A
F
L
K
G
R
I
R
F
G
G
I
H
R
V
I
E
K
T
L
---
E
E
F
Q
G
Y
--
P
Q
P
R
--
T
L
D
D
V
E
R
I
H
F
E
A
I
K
K
A
E
R
V
T
E
W
L
S
-