@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3652: (2016-02-19 )
MEKTRKDVCVPRHVAIIMDGNNRWAKKRLLPGVAGHKAGVDAVRAVIEVCAEAGVEVLTLFAFSSENWQRPADEVSALMELFLVALRREVRKLDENGIRLRIIGDRTRFHPELQAAMREAEAATAGNTRFLLQVAANYGGQWDIVQAAQRLAREVQGGHLAADDISAELLQGCLVTGDQPLPDLCIRTGGEHRISNFLLWQLAYAELYFSDLFWPDFKHAAMRAALADFSKRQRRFGKTSEQVEAEARPSC
Atome Classification :
(53 SA)
.........10.......-.20........30...-.....40........50........60...-.....70........80........90........100.......110.......120.......130.......140.......150........160......-.170.---...-...180---.-.......190.......200.......210.......220.......230.......240.......250
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEKTRKDVCVP
R
H
V
A
I
I
M
-DGNN
R
W
A
K
K
RLLPGVA-GHK
A
G
V
D
A
V
R
A
V
I
E
V
C
A
EAG
V
E
V
L
T
L
F
A
FS-SENWQR
P
A
D
E
V
S
A
L
M
E
L
F
L
V
A
L
R
R
E
V
R
K
LDENG
I
R
L
R
I
IGDRTRF
H
P
E
L
Q
A
A
M
R
E
A
EAATAGN
T
R
F
L
L
Q
V
A
A
NYGGQ
W
D
I
V
Q
A
A
Q
R
L
-
A
R
E
VQGGHL
A
A
D
D
I
S
A
E
-
L
L
Q
G
C
---LVT-GDQP
L
----
P
-
D
L
C
I
RTGG
E
H
R
I
S
N
F
L
L
W
Q
L
A
Y
A
E
L
Y
F
S
DLFWP
D
F
K
H
A
A
M
R
A
A
L
A
D
F
S
K
R
Q
R
RFGK
T
S
E
Q
V
EAEARPSC
40
PsiBlast_CBE
98.19
57%
-119
- C9 -
1X08
3
UPPS_ECOLI
A:
[19-240]
-----------
R
H
V
A
I
I
M
-
A
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
39
PsiBlast_CBE
98.10
57%
-118
- C9 -
1X09
3
UPPS_ECOLI
A:
[19-239]
-----------
R
H
V
A
I
I
M
-
A
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
-------------------
38
PsiBlast_CBE
97.25
57%
-128
- C9 -
1UEH
9
UPPS_ECOLI
B:
[19-241]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
-----------------
3
PsiBlast_PDB
97.05
57%
-122
- C9 -
1V7U
2
UPPS_ECOLI
A:
[19-239]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
-------------------
4
PsiBlast_PDB
96.94
57%
-118
- C9 -
1X06
4
UPPS_ECOLI
A:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
5
PsiBlast_PDB
96.24
57%
-122
- C9 -
1X07
3
UPPS_ECOLI
A:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
37
PsiBlast_CBE
95.21
57%
-125
- C9 -
1V7U
1
UPPS_ECOLI
B:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
----
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
13
PsiBlast_PDB
95.16
57%
-124
- C9 -
3SGT
1
UPPS_ECOL6
B:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
---
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
7
PsiBlast_PDB
95.09
57%
-121
- C9 -
2E99
3
UPPS_ECOLI
A:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
31
PsiBlast_CBE
95.08
57%
-125
- C9 -
3SGV
3
UPPS_ECOLI
A:
[19-238]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
--------------------
6
PsiBlast_PDB
94.69
57%
-122
- C9 -
2E98
4
UPPS_ECOLI
A:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
16
PsiBlast_PDB
94.02
57%
-129
- C9 -
3SH0
2
UPPS_ECOLI
B:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
------
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
28
PsiBlast_CBE
93.39
57%
-132
- C9 -
3WYJ
1
UPPS_ECOLI
A:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
-----
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
10
PsiBlast_PDB
93.22
57%
-123
- C9 -
2E9D
2
UPPS_ECOLI
A:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
--------
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
8
PsiBlast_PDB
93.14
57%
-122
- C9 -
2E9A
2
UPPS_ECOLI
A:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
---------
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
20
PsiBlast_PDB
92.95
57%
-130
- C9 -
4H38
1
UPPS_ECOLI
A:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
------------
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
32
PsiBlast_CBE
92.93
57%
-127
- C9 -
2E9D
1
UPPS_ECOLI
B:
[19-243]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
F
---------------
34
PsiBlast_CBE
92.77
57%
-129
- C9 -
2E9A
1
UPPS_ECOLI
B:
[19-242]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-------------
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
----------------
17
PsiBlast_PDB
92.70
57%
-126
- C9 -
4H2J
1
UPPS_ECOLI
A:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
-----------
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
36
PsiBlast_CBE
92.52
57%
-130
- C9 -
2E98
3
UPPS_ECOLI
B:
[19-243]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
F
---------------
18
PsiBlast_PDB
92.25
57%
-128
- C9 -
4H2M
1
UPPS_ECOLI
A:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
------------
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
14
PsiBlast_PDB
91.99
57%
-131
- C9 -
3SGV
2
UPPS_ECOLI
B:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
------------
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
69
HHSearch
91.87
56%
-126
- C9 -
3SGV
2
UPPS_ECOLI
B:
[13-240]
-----
L
P
A
H
G
C
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
------------
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
35
PsiBlast_CBE
91.82
57%
-127
- C9 -
2E99
2
UPPS_ECOLI
B:
[19-243]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
F
---------------
33
PsiBlast_CBE
91.82
57%
-125
- C9 -
2E9C
1
UPPS_ECOLI
B:
[19-239]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
-------------------
58
PsiBlast_CBE
91.81
40%
-116
- C9 -
2VG2
8
DPDS_MYCTU
C:
[55-283]
---------
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
I
A
R
H
---
L
Q
R
-
P
D
I
P
D
----
V
-
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
-------------
57
PsiBlast_CBE
91.65
40%
-116
- C9 -
2VG2
5
DPDS_MYCTU
D:
[55-283]
---------
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
I
A
R
H
---
L
Q
R
-
P
D
I
P
D
----
V
-
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
-------------
15
PsiBlast_PDB
91.07
57%
-125
- C9 -
3SGX
2
UPPS_ECOLI
A:
[19-238]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
-----------
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
--------------------
51
PsiBlast_CBE
90.90
40%
-113
- C9 -
4ONC
2
DPDS_MYCTU
B:
[55-283]
---------
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
I
A
R
H
---
L
Q
R
-
P
D
I
P
D
----
V
-
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
-------------
29
PsiBlast_CBE
90.51
57%
-124
- C9 -
3TH8
1
UPPS_ECOLI
B:
[19-239]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
----------------
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
-------------------
54
PsiBlast_CBE
90.30
40%
-115
- C9 -
2VG3
6
DPDS_MYCTU
C:
[55-283]
---------
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
I
A
R
H
---
L
Q
R
-
P
D
I
P
D
----
V
-
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
-------------
23
PsiBlast_CBE
90.26
57%
-129
- C9 -
4H3C
2
UPPS_ECOLI
A:
[19-239]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
----------------
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
-------------------
43
PsiBlast_CBE
90.10
44%
-115
- C9 -
4Q9M
8
ISPT_STRR6
B:
[13-239]
---------
V
P
A
H
I
G
I
I
M
-
D
G
N
G
R
W
A
K
K
R
M
Q
P
R
V
F
-
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
-
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
L
H
A
N
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
-
S
Q
D
V
L
D
A
K
I
N
P
G
D
I
T
E
E
-
L
I
G
N
Y
---
L
F
T
-
Q
H
L
P
K
DLRD
P
-
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
-------------------
52
PsiBlast_CBE
90.08
40%
-116
- C9 -
4ONC
1
DPDS_MYCTU
A:
[55-280]
---------
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
I
A
R
H
---
L
Q
R
-
P
D
I
P
D
----
V
-
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
----------------
53
PsiBlast_CBE
89.28
40%
-119
- C9 -
2VG3
3
DPDS_MYCTU
D:
[55-283]
---------
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
I
A
R
H
---
L
Q
R
-
P
D
I
P
D
----
V
-
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
-------------
21
PsiBlast_CBE
89.10
57%
-127
- C9 -
5CQJ
1
?
A:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
-----------------
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
71
HHSearch
89.03
39%
-109
- C9 -
2VG3
6
DPDS_MYCTU
A:
[48-283]
--
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
I
A
R
H
---
L
Q
R
-
P
D
I
P
D
----
V
-
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
-------------
59
PsiBlast_CBE
88.99
40%
-115
- C9 -
2VG2
6
DPDS_MYCTU
B:
[55-283]
---------
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
I
A
R
H
---
L
Q
R
-
P
D
I
P
D
----
V
-
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
-------------
44
PsiBlast_CBE
88.67
44%
-110
- C9 -
4Q9M
12
ISPT_STRR6
A:
[13-240]
---------
V
P
A
H
I
G
I
I
M
-
D
G
N
G
R
W
A
K
K
R
M
Q
P
R
V
F
-
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
-
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
L
H
A
N
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
-
S
Q
D
V
L
D
A
K
I
N
P
G
D
I
T
E
E
-
L
I
G
N
Y
---
L
F
T
-
Q
H
L
P
K
DLRD
P
-
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
H
------------------
79
Fugue
88.66
53%
-116
* C9 *
1JP3
1
UPPS_ECOLI
A:
[13-240]
-----
L
P
A
H
G
C
R
H
V
A
I
I
-M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
M
--------------
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
60
PsiBlast_CBE
88.66
40%
-114
- C9 -
2VG2
9
DPDS_MYCTU
A:
[55-283]
---------
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
I
A
R
H
---
L
Q
R
-
P
D
I
P
D
----
V
-
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
-------------
56
PsiBlast_CBE
88.65
40%
-114
- C9 -
2VG3
6
DPDS_MYCTU
A:
[55-283]
---------
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
I
A
R
H
---
L
Q
R
-
P
D
I
P
D
----
V
-
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
-------------
48
PsiBlast_CBE
88.36
39%
-112
- C9 -
4H8E
3
ISPT_STAAN
A:
[24-253]
---------
I
P
E
H
I
A
I
I
M
-
D
G
N
G
R
W
A
K
K
R
K
M
P
R
I
K
-
G
H
Y
E
G
M
Q
T
I
K
K
I
T
R
I
A
S
D
I
G
V
K
Y
L
T
L
Y
A
F
S
-
T
E
N
W
S
R
P
E
S
E
V
N
Y
I
M
N
L
P
V
N
F
L
K
T
F
L
P
E
L
I
E
K
N
V
K
V
E
T
I
G
F
T
D
K
L
P
K
S
T
I
E
A
I
N
N
A
K
E
K
T
A
N
N
T
G
L
K
L
I
F
A
I
N
Y
G
G
R
A
E
L
V
H
S
I
K
N
M
-
F
D
E
L
H
Q
Q
G
L
N
S
D
I
I
D
E
T
-
Y
I
N
N
H
---
L
M
T
-
K
D
Y
P
D
----
P
-
E
L
L
I
R
T
S
G
E
Q
R
I
S
N
F
L
I
W
Q
V
S
Y
S
E
F
I
F
N
Q
K
L
W
P
D
F
D
E
D
E
L
I
K
C
I
K
I
Y
Q
S
R
Q
R
R
F
G
G
L
------------
9
PsiBlast_PDB
88.03
57%
-122
- C9 -
2E9C
3
UPPS_ECOLI
A:
[19-240]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
-------------------
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
55
PsiBlast_CBE
87.87
40%
-113
- C9 -
2VG3
7
DPDS_MYCTU
B:
[55-283]
---------
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
I
A
R
H
---
L
Q
R
-
P
D
I
P
D
----
V
-
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
-------------
47
PsiBlast_CBE
86.56
39%
-112
- C9 -
4U82
3
ISPT_STAAN
A:
[24-254]
---------
I
P
E
H
I
A
I
I
M
-
D
G
N
G
R
W
A
K
K
R
K
M
P
R
I
K
-
G
H
Y
E
G
M
Q
T
I
K
K
I
T
R
I
A
S
D
I
G
V
K
Y
L
T
L
Y
A
F
S
-
T
E
N
W
S
R
P
E
S
E
V
N
Y
I
M
N
L
P
V
N
F
L
K
T
F
L
P
E
L
I
E
K
N
V
K
V
E
T
I
G
F
T
D
K
L
P
K
S
T
I
E
A
I
N
N
A
K
E
K
T
A
N
N
T
G
L
K
L
I
F
A
I
N
Y
G
G
R
A
E
L
V
H
S
I
K
N
M
-
F
D
E
L
H
Q
Q
G
L
N
S
D
I
I
D
E
T
-
Y
I
N
N
H
---
L
M
T
-
K
D
Y
P
D
----
P
-
E
L
L
I
R
T
S
G
E
Q
R
I
S
N
F
L
I
W
Q
V
S
Y
S
E
F
I
F
N
Q
K
L
W
P
D
F
D
E
D
E
L
I
K
C
I
K
I
Y
Q
S
R
Q
R
R
F
G
G
L
S
-----------
19
PsiBlast_PDB
86.04
57%
-122
- C9 -
4H2O
2
UPPS_ECOLI
B:
[19-239]
-----------
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
----------------
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
--
Q
P
D
Q
I
D
E
E
-
M
L
N
Q
H
---
V
C
M
-
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
-------------------
80
Fugue
83.99
52%
-103
- C9 -
1JP3
1
UPPS_ECOLI
A:
[13-240]
L
P
A
H
-----
G
C
R
H
V
A
I
I
-M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
---------------
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
M
L
N
Q
H
-----
V
C
M
H
E
L
A
P
----
V
-
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------------------
63
PsiBlast_CBE
82.34
37%
-117
- C9 -
2VG1
6
ZFPP_MYCTU
B:
[3-228]
---------
L
P
R
H
I
A
V
L
C
-
D
G
N
R
R
W
A
R
S
A
G
Y
D
D
V
S
Y
G
Y
R
M
G
A
A
K
I
A
E
M
L
R
W
C
H
E
A
G
I
E
L
A
T
V
Y
L
L
S
-
T
E
N
L
Q
R
D
P
D
E
L
A
A
L
I
E
I
I
T
D
V
V
--
E
E
I
C
A
P
A
N
H
W
S
V
R
T
V
G
D
L
G
L
I
G
E
E
P
A
R
R
L
R
G
A
V
E
S
T
P
E
V
A
S
F
H
V
N
V
A
V
G
Y
G
G
R
R
E
I
V
D
A
V
R
A
L
L
S
K
E
L
A
N
G
A
T
A
E
E
L
V
D
A
V
-
T
V
E
G
I
SEN
L
Y
T
-
S
G
Q
P
D
----
P
-
D
L
V
I
R
T
S
G
E
Q
R
L
S
G
F
L
L
W
Q
S
A
Y
S
E
M
W
F
T
E
A
H
W
P
A
F
R
H
V
D
F
L
R
A
L
R
D
Y
S
A
R
-------------------
62
PsiBlast_CBE
81.51
35%
-118
- C9 -
3UGS
2
ISPT_CAMJE
A:
[8-224]
-----------
K
H
L
A
V
V
M
-
D
G
N
R
-----------------
G
V
K
T
M
Q
K
L
M
E
V
C
M
E
E
N
I
S
N
L
S
L
F
A
F
S
-
T
E
N
W
K
R
P
K
D
E
I
D
F
I
F
E
L
L
D
R
C
L
D
E
A
L
E
K
F
E
K
N
N
V
R
L
R
A
I
G
D
L
S
R
L
E
D
K
V
R
E
K
I
T
L
V
E
E
K
T
K
H
C
D
A
L
C
V
N
L
A
I
S
Y
G
A
R
D
E
I
I
R
A
A
K
R
V
-
I
E
--
K
K
L
E
L
N
E
E
N
L
T
Q
N
-
L
------------
D
L
P
L
----
D
V
D
L
M
L
R
V
G
N
A
K
R
L
S
N
F
L
L
W
Q
C
S
Y
A
E
I
Y
F
S
E
T
L
F
P
S
L
T
K
R
E
F
K
R
I
I
K
E
F
R
N
R
E
R
T
F
G
--------------
61
PsiBlast_CBE
80.60
35%
-113
- C9 -
3UGS
2
ISPT_CAMJE
B:
[8-225]
-----------
K
H
L
A
V
V
M
-
D
G
N
R
---------------
S
Q
G
V
K
T
M
Q
K
L
M
E
V
C
M
E
E
N
I
S
N
L
S
L
F
A
F
S
-
T
E
N
W
K
R
P
K
D
E
I
D
F
I
F
E
L
L
D
R
C
L
D
E
A
L
E
K
F
E
K
N
N
V
R
L
R
A
I
G
D
L
S
R
L
E
D
K
V
R
E
K
I
T
L
V
E
E
K
T
K
H
C
D
A
L
C
V
N
L
A
I
S
Y
G
A
R
D
E
I
I
R
A
A
K
R
V
-
I
E
--
K
K
L
E
L
N
E
E
N
L
T
Q
N
-
L
------------
D
L
P
L
----
D
V
D
L
M
L
R
V
G
N
A
K
R
L
S
N
F
L
L
W
Q
C
S
Y
A
E
I
Y
F
S
E
T
L
F
P
S
L
T
K
R
E
F
K
R
I
I
K
E
F
R
N
R
E
R
T
F
G
K
-------------
50
PsiBlast_CBE
79.25
40%
-115
- C9 -
2DTN
1
ISPT_HELPY
B:
[17-242]
-----------
K
H
L
A
I
I
M
-
D
G
N
G
R
W
A
K
L
K
N
K
A
R
A
Y
-
G
H
K
K
G
V
K
T
L
K
D
I
T
I
W
C
A
N
H
K
L
E
C
L
T
L
Y
A
-----------------
M
K
M
L
K
K
Y
L
K
D
E
R
S
T
Y
L
D
N
N
I
R
F
R
A
I
G
D
L
E
G
F
S
K
E
L
R
D
T
I
L
Q
L
E
N
D
T
R
H
F
K
D
F
T
Q
V
L
A
L
N
Y
G
S
K
N
E
L
S
R
A
F
K
S
L
-
L
E
S
P
---------
L
E
N
E
--
I
S
N
R
---
L
D
T
-
R
N
L
P
E
----
V
-
D
L
L
L
R
T
G
G
E
M
R
L
S
N
F
L
L
W
Q
S
S
Y
A
E
L
F
F
T
P
I
L
W
P
D
F
T
P
K
D
L
E
N
I
I
S
D
F
Y
K
R
V
R
K
F
G
E
-------------
72
HHSearch
78.39
35%
-116
- C9 -
3UGS
2
ISPT_CAMJE
B:
[4-225]
-------
M
N
E
L
K
H
L
A
V
V
M
-
D
G
N
R
---------------
S
Q
G
V
K
T
M
Q
K
L
M
E
V
C
M
E
E
N
I
S
N
L
S
L
F
A
F
S
-
T
E
N
W
K
R
P
K
D
E
I
D
F
I
F
E
L
L
D
R
C
L
D
E
A
L
E
K
F
E
K
N
N
V
R
L
R
A
I
G
D
L
S
R
L
E
D
K
V
R
E
K
I
T
L
V
E
E
K
T
K
H
C
D
A
L
C
V
N
L
A
I
S
Y
G
A
R
D
E
I
I
R
A
A
K
R
V
-
I
E
K
K
-------
L
E
L
N
E
E
-
N
L
T
Q
N
---
L
D
L
---
P
L
D
----
V
-
D
L
M
L
R
V
G
N
A
K
R
L
S
N
F
L
L
W
Q
C
S
Y
A
E
I
Y
F
S
E
T
L
F
P
S
L
T
K
R
E
F
K
R
I
I
K
E
F
R
N
R
E
R
T
F
G
K
-------------