@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3700: (2016-02-20 )
MSDQQLDQHELQQEENKLIAQRKEKLAAVREARAIAFPNDFRRDAYFADLQKQYADKTKEELEAAAIPVKVAGRIMLNRGSFIVLQDSSERLQVYVNRKTLPEETLAEIKTWDLGDIIGAEGVLARSGKGDLYVDMTSVRLLTKSLRPLPDKHHGLTDTEQRYRQRYVDLMVNEETRHTFRVRSQVIAHIRRFLSERGFLEVETPMLQTIPGGAAAKPFETHHNALDMAMFLRIAPELYLKRLVVGGFEKVFEINRNFRNEGVSTRHNPEFTMLEFYQAYADYEDNMDLTEELFRELAQSVLGTTDVPYGDKVFHFGEPFVRLSVFDSILKYNPEITAADLNDVEKARAIAKKAGAKVLGHEGLGKLQVMIFEELVEHKLEQPHFITRYPFEVSPLARRNDEDPSVTDRFELFIGGREIANAYSELNDAEDQAERFMLQVKEKDAGDDEAMHYDADFINALEYGMPPTAGEGIGIDRLVMLLTNSPSIRDVILFPHMRPQA
Atome Classification :
(31 SA)
.........10........20........30........40........50........60........70.....----...----80---.-----........90......-..100---.....-.-.-.110........120.......130.......140.......150.......160.......170.......180.......190.......200...-....-210.......220.----......230.......240.......250.......260.......270.......280.......290.......300.......------310.-......320.......330----------........340.......350-.........-360--.........370.......380.........390...-....400.......410.......420.......430.......440..-.....450.......460.......470.......480.......490.......500
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
D
Q
Q
L
D
Q
H
E
L
Q
Q
E
E
N
K
L
I
A
Q
R
K
E
K
L
A
A
V
R
E
A
R
AIAF
P
N
D
FRRD
A
Y
F
A
D
L
Q
K
Q
Y
A
D
K
T
K
E
E
L
E
A
AA
I
P
V
K
V
A
G
R
I
M
----LNR----G----
S
-----
F
I
V
LQDSS
E
R
L
Q
V
Y
V
N-RKTL----
P
E
E
T
L
-
A
-
E
-IKT-WDL
G
D
IIGAE
G
V
L
ARSGKG
D
L
Y
V
D
M
T
S
V
R
L
L
T
K
SLRPLPDKHHGLT
D
T
E
Q
R
Y
R
Q
R
Y
V
D
L
MVNEET
R
H
T
F
R
V
R
S
Q
V
I
A
H
I
R
R
F
L
S
ERG
F
L
E
VET
P
-
M
L
QT-IPGGAAAKP
F
E
T
HH----
N
A
L
D
M
A
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
V
VG
G
F
E
K
V
F
E
I
N
R
N
F
RNEGVSTRHNPE
F
T
M
L
E
F
Y
Q
A
Y
ADYEDN
M
D
L
T
E
E
L
F
R
E
L
A
Q
S
V
LGTTDVPY------GDKV-FHFGE
P
F
V
R
L
S
V
F
D
S
I
L
K-----------YNPEITAA
D
L
N
D
V
E
K
A
R
A
I
---
A
K
KAGAKVL-G----HEGL
G
K
L
Q
V
M
I
F
E
E
L
V
E
H
KL--EQP
H
F
I
T
RYPFEVSP-LARRNDEDPSVT
D
R
F
E
L
F
IG
G
R
E
I
A
N
A
Y
S
ELND
A
E
D
Q
A
E
R
F
M
L
Q
VKEKD-AGDDEAMHY
D
A
D
F
I
N
A
L
EYGMPPTAGEGI
G
I
D
R
L
V
M
L
LTNSPS
I
R
D
V
I
L
FPHMRPQA
21
PsiBlast_CBE
93.31
61%
-85
- C5 -
1LYL
1
SYK2_ECOLI
C:
[15-502]
---------------
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
-
Q
G
V
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
TRRI
M
G
K
----
A
----
S
-----
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
-
R
D
S
L
----
P
E
G
V
Y
-
N
D
Q
-
F
K
K
-
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
-
M
M
Q
V
-
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
V
T
Y
------
G
E
H
V
-
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
-----------
Y
R
P
E
T
D
M
A
D
L
D
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
-
K
----
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
--
7
PsiBlast_PDB
93.17
61%
-86
- C5 -
1E24
7
SYK2_ECOLI
A:
[15-502]
---------------
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
-
Q
G
V
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
K
----
A
----
S
-----
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
-
R
D
S
L
----
P
E
G
V
Y
-
N
D
Q
-
F
K
K
-
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
-
M
M
Q
V
-
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
V
T
Y
------
G
E
H
V
-
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
-----------
Y
R
P
E
T
D
M
A
D
L
D
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
-
K
----
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
--
3
PsiBlast_PDB
93.13
61%
-84
- C5 -
1LYL
1
SYK2_ECOLI
A:
[15-502]
---------------
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
-
Q
G
V
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
K
----
A
----
S
-----
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
-
R
D
S
L
----
P
E
G
V
Y
-
N
D
Q
-
F
K
K
-
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
-
M
M
Q
V
-
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
V
T
Y
------
G
E
H
V
-
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
-----------
Y
R
P
E
T
D
M
A
D
L
D
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
-
K
----
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
--
22
PsiBlast_CBE
92.78
61%
-86
- C5 -
1LYL
1
SYK2_ECOLI
B:
[15-502]
---------------
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
-
Q
G
V
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
K
----
A
----
S
-----
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
-
R
D
S
L
----
P
E
G
V
Y
-
N
D
Q
-
F
K
K
-
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
-
M
M
Q
V
-
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
V
T
Y
------
G
E
H
V
-
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
-----------
Y
R
P
E
T
D
M
A
D
L
D
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
-
K
----
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
--
1
PsiBlast_PDB
92.78
62%
-84
- C5 -
1BBU
1
SYK1_ECOLI
A:
[15-502]
---------------
N
N
E
L
K
T
R
R
E
K
L
A
N
L
R
E
-
Q
G
I
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
A
E
F
D
G
K
E
N
E
E
L
E
A
L
N
I
E
V
A
V
A
G
R
M
M
T
R
R
I
M
G
K
----
A
----
S
-----
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
-
R
D
D
L
----
P
E
G
V
Y
-
N
-
E
Q
F
K
K
-
W
D
L
G
D
I
L
G
A
K
G
K
L
F
K
T
K
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
A
R
Y
R
Q
R
Y
L
D
L
I
S
N
D
E
S
R
N
T
F
K
V
R
S
Q
I
L
S
G
I
R
Q
F
M
V
N
R
G
F
M
E
V
E
T
P
-
M
M
Q
V
-
I
P
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
K
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
D
I
L
G
K
T
E
V
T
Y
------
G
D
V
T
-
L
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
-----------
Y
R
P
E
T
D
M
A
D
L
D
N
F
D
S
A
K
A
I
---
A
E
S
I
G
I
H
V
E
-
K
----
S
W
G
L
G
R
I
V
T
E
I
F
E
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
Q
R
F
L
D
Q
V
A
A
K
D
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
H
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
V
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
--
6
PsiBlast_PDB
92.53
61%
-84
- C5 -
1E22
11
SYK2_ECOLI
A:
[15-502]
---------------
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
-
Q
G
V
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
K
----
A
----
S
-----
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
-
R
D
S
L
----
P
E
G
V
Y
-
N
D
Q
-
F
K
K
-
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
-
M
M
Q
V
-
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
V
T
Y
------
G
E
H
V
-
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
-----------
Y
R
P
E
T
D
M
A
D
L
D
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
-
K
----
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
--
71
Fugue
92.52
61%
-84
- C5 -
1LYL
1
SYK2_ECOLI
A:
[14-502]
--------------
F
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
-
V
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
----
T
R
R
----
I
----
M
GK
A
S
-
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
-
R
---DSLP
E
G
V
Y
N
-
D
-
Q
-
F
K
K
-
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
-------
D
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
-
M
M
Q
V
-
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
V
T
Y
------
G
E
H
V
-
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
-----------
Y
R
P
E
T
D
M
A
D
L
D
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
-
K
----
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I--
Q
P
T
F
I
T
E
Y
P
A
E
V
S
-P
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
--
81
HHSearch
92.41
61%
-84
- C5 -
1E1O
9
SYK2_ECOLI
A:
[11-502]
-----------
A
I
D
F
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
----
T
R
R
I
M
GK
A
----
S
-----
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
-
R
D
S
L
----
P
E
G
V
Y
N
D
-
Q
-
F
K
K
-
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
-
M
M
Q
V
-
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
V
T
Y
------
G
E
H
V
-
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
-----------
Y
R
P
E
T
D
M
A
D
L
D
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
-
K
----
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
--
5
PsiBlast_PDB
92.30
61%
-83
- C5 -
1E1T
11
SYK2_ECOLI
A:
[15-502]
---------------
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
-
Q
G
V
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
K
----
A
----
S
-----
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
-
R
D
S
L
----
P
E
G
V
Y
-
N
D
Q
-
F
K
K
-
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
-
M
M
Q
V
-
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
V
T
Y
------
G
E
H
V
-
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
-----------
Y
R
P
E
T
D
M
A
D
L
D
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
-
K
----
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
--
4
PsiBlast_PDB
92.11
61%
-85
- C5 -
1E1O
9
SYK2_ECOLI
A:
[15-502]
---------------
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
-
Q
G
V
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
K
----
A
----
S
-----
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
-
R
D
S
L
----
P
E
G
V
Y
-
N
D
Q
-
F
K
K
-
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
-
M
M
Q
V
-
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
V
T
Y
------
G
E
H
V
-
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
-----------
Y
R
P
E
T
D
M
A
D
L
D
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
-
K
----
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
--
8
PsiBlast_PDB
92.07
58%
-88
- C5 -
4EX5
1
SYK_BURTA
A:
[36-526]
--------------
E
N
Q
I
V
A
E
R
R
D
K
L
R
A
L
R
D
-
Q
G
I
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
T
A
Y
A
D
A
D
K
E
A
L
E
A
K
S
L
E
V
A
I
A
G
R
M
M
----
L
K
R
V
M
GK
A
----
S
-----
F
A
T
V
Q
D
G
S
G
Q
I
Q
F
F
V
T
-
P
A
D
V
----
G
A
E
T
Y
-
D
-
A
-
F
K
K
-
W
D
L
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
------
D
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
-
M
L
H
P
-
I
P
G
G
A
A
A
K
P
F
V
T
H
H
----
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
A
V
D
A
L
G
T
A
T
I
Q
Y
------
Q
G
R
E
-
L
D
L
A
Q
P
F
H
R
L
T
I
T
Q
A
I
Q
K
-----------
Y
A
P
S
Y
T
D
G
Q
L
S
D
D
A
F
L
R
S
E
---
L
K
R
L
G
V
D
V
T
-
Q
PAFL
N
A
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
--
W
E
P
T
F
I
I
D
Y
P
I
E
V
S
P
-
L
A
R
E
S
D
T
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
A
A
R
F
K
K
Q
V
E
Q
K
D
-
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
---
23
PsiBlast_CBE
91.30
58%
-88
- C5 -
4EX5
1
SYK_BURTA
B:
[35-526]
-------------
D
E
N
Q
I
V
A
E
R
R
D
K
L
R
A
L
R
D
-
Q
G
I
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
T
A
Y
A
D
A
D
K
E
A
L
E
A
K
S
L
E
V
A
I
A
G
R
M
M
----
L
K
R
V
M
GK
A
----
S
-----
F
A
T
V
Q
D
G
S
G
Q
I
Q
F
F
V
T
-
P
A
D
V
----
G
A
E
T
Y
-
D
-
A
-
F
K
K
-
W
D
L
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
-------
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
-
M
L
H
P
-
I
P
G
G
A
A
A
K
P
F
V
T
H
H
----
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
A
V
D
A
L
G
T
A
T
I
Q
Y
------
Q
G
R
E
-
L
D
L
A
Q
P
F
H
R
L
T
I
T
Q
A
I
Q
K
-----------
Y
A
P
S
Y
T
D
G
Q
L
S
D
D
A
F
L
R
S
E
---
L
K
R
L
G
V
D
V
T
-
Q
PAFL
N
A
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
--
W
E
P
T
F
I
I
D
Y
P
I
E
V
S
P
-
L
A
R
E
S
D
T
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
A
A
R
F
K
K
Q
V
E
Q
K
D
-
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
---
2
PsiBlast_PDB
91.27
62%
-92
- C5 -
1BBW
-
SYK1_ECOLI
A:
[15-502]
---------------
N
N
E
L
K
T
R
R
E
K
L
A
N
L
R
E
-
Q
G
I
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
A
E
F
D
G
K
E
N
E
E
L
E
A
L
N
I
E
V
A
V
A
G
R
M
M
T
R
R
I
M
G
K
----
A
----
S
-----
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
-
R
D
D
L
----
P
E
G
V
Y
-
N
-
E
Q
F
K
K
-
W
D
L
G
D
I
L
G
A
K
G
K
L
F
K
T
K
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
A
R
Y
R
Q
R
Y
L
D
L
I
S
N
D
E
S
R
N
T
F
K
V
R
S
Q
I
L
S
G
I
R
Q
F
M
V
N
R
G
F
M
E
V
E
T
P
-
M
M
Q
V
-
I
P
---
A
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
K
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
D
I
L
G
K
T
E
V
T
Y
------
G
D
V
T
-
L
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
-----------
Y
R
P
E
T
D
M
A
D
L
D
N
F
D
S
A
K
A
I
---
A
E
S
I
G
I
H
V
E
-
K
----
S
W
G
L
G
R
I
V
T
E
I
F
E
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
Q
R
F
L
D
Q
V
-------------
Y
D
E
D
Y
V
T
A
L
E
H
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
V
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
--
9
PsiBlast_PDB
87.53
52%
-77
- C5 -
3E9H
2
SYK_GEOSE
A:
[4-491]
-------------
E
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
M
G
K
A
G
-----
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
-
Q
D
D
V
----
G
E
Q
Q
Y
-
E
-
L
-
F
K
I
-
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
-
M
M
H
A
-
V
A
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
I
Q
Y
------
G
E
H
L
-
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-----------
Y
V
G
V
D
F
W
R
Q
M
S
D
-
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
-
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
--
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
-
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
---
82
HHSearch
87.46
52%
-77
- C5 -
3A74
5
SYK_GEOSE
A:
[4-492]
-------------
E
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
----
T
K
R
G
M
GK
A
----
G
-----
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
-
Q
D
D
V
----
G
E
Q
Q
Y
-
E
-
L
-
F
K
I
-
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
-
M
M
H
A
-
V
A
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
I
Q
Y
------
G
E
H
L
-
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-----------
Y
V
G
V
D
F
W
R
Q
M
S
-
D
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
-
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
--
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
-
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
--
27
PsiBlast_CBE
87.43
52%
-75
- C5 -
3E9H
2
SYK_GEOSE
D:
[4-491]
-------------
E
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
MGKA
G
-----
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
-
Q
D
D
V
----
G
E
Q
Q
Y
-
E
-
L
-
F
K
I
-
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
-
M
M
H
A
-
V
A
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
I
Q
Y
------
G
E
H
L
-
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-----------
Y
V
G
V
D
F
W
R
Q
M
S
D
-
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
-
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
--
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
-
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
---
30
PsiBlast_CBE
87.37
52%
-76
- C5 -
3A74
5
SYK_GEOSE
D:
[4-491]
-------------
E
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
MGKA
G
-----
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
-
Q
D
D
V
----
G
E
Q
Q
Y
-
E
-
L
-
F
K
I
-
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
-
M
M
H
A
-
V
A
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
I
Q
Y
------
G
E
H
L
-
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-----------
Y
V
G
V
D
F
W
R
Q
M
S
D
-
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
-
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
--
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
-
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
---
11
PsiBlast_PDB
87.29
52%
-76
- C5 -
3A74
5
SYK_GEOSE
A:
[4-491]
-------------
E
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
M
GK
A
G
-----
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
-
Q
D
D
V
----
G
E
Q
Q
Y
-
E
-
L
-
F
K
I
-
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
-
M
M
H
A
-
V
A
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
I
Q
Y
------
G
E
H
L
-
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-----------
Y
V
G
V
D
F
W
R
Q
M
S
D
-
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
-
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
--
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
-
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
---
26
PsiBlast_CBE
87.22
52%
-75
- C5 -
3E9I
4
SYK_GEOSE
B:
[4-491]
-------------
E
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
MGKA
G
-----
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
-
Q
D
D
V
----
G
E
Q
Q
Y
-
E
-
L
-
F
K
I
-
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
-
M
M
H
A
-
V
A
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
I
Q
Y
------
G
E
H
L
-
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-----------
Y
V
G
V
D
F
W
R
Q
M
S
D
-
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
-
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
--
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
-
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
---
31
PsiBlast_CBE
87.15
52%
-76
- C5 -
3A74
5
SYK_GEOSE
C:
[4-491]
-------------
E
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
MGKA
G
-----
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
-
Q
D
D
V
----
G
E
Q
Q
Y
-
E
-
L
-
F
K
I
-
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
-
M
M
H
A
-
V
A
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
I
Q
Y
------
G
E
H
L
-
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-----------
Y
V
G
V
D
F
W
R
Q
M
S
D
-
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
-
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
--
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
-
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
---
14
PsiBlast_PDB
79.41
42%
-77
- C5 -
4YCU
4
SYK_HUMAN
A:
[27-508]
------------------------------------
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
Q
K
Y
S
H
L
Q
P
G
D
-
H
L
T
D
I
T
L
K
V
A
G
R
I
H
----
A
K
R
----
A
----
S
G
GK
L
I
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
N
S
R
N
Y
K
----
S
E
E
E
F
-
I
-
H
-
I
N
N
K
L
R
R
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
H
F
G
L
K
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
-
M
M
N
I
-
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
----
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
G
S
Y
K
V
T
Y
H
PDGPE
G
Q
A
Y
D
V
D
F
T
P
P
F
R
R
I
N
M
V
E
E
L
E
K
A
L
G
M
K
L
P
E
TNL
F
E
T
E
E
T
R
K
I
L
D
D
I
C
V
A
K
A
V
E
C
P
P
P
R
T
T
A
R
L
L
-
D
----
K
---------
L
V
G
E
F
L
E
V
T
C
--
I
N
P
T
F
I
C
D
H
P
Q
I
M
S
P
-
L
A
K
W
H
R
S
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
R
Q
L
F
E
E
Q
A
K
A
K
A
-
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
P
E
-
36
PsiBlast_CBE
78.68
42%
-78
- C5 -
4YCU
4
SYK_HUMAN
B:
[27-507]
------------------------------------
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
Q
K
Y
S
H
L
Q
P
G
D
-
H
L
T
D
I
T
L
K
V
A
G
R
I
H
----
A
K
R
----
A
----
S
G
GK
L
I
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
N
S
R
N
Y
K
----
S
E
E
E
F
-
I
-
H
-
I
N
N
K
L
R
R
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
-----
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
-
M
M
N
I
-
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
----
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
G
S
Y
K
V
T
Y
HPDGPE
G
Q
A
Y
D
V
D
F
T
P
P
F
R
R
I
N
M
V
E
E
L
E
K
A
L
GMKLPETNL
F
E
T
E
E
T
R
K
I
L
D
D
I
C
V
A
K
A
V
E
C
P
P
P
R
T
T
A
R
L
L
-
D
----
K
---------
L
V
G
E
F
L
E
V
T
C
--
I
N
P
T
F
I
C
D
H
P
Q
I
M
S
P
-
L
A
K
W
H
R
S
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
R
Q
L
F
E
E
Q
A
K
A
K
A
-
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
P
--
52
PsiBlast_CBE
60.47
42%
-68
- C5 -
4UPA
1
?
A:
[12-377]
----------------
Q
L
F
L
N
R
C
K
D
V
E
E
Y
Q
K
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
S
D
D
I
--
V
S
V
A
G
R
V
L
----
S
K
R
----
S
----
S
SSA
L
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
N
-
K
S
A
Y
EN--
K
E
D
F
V
-
S
-
L
-
T
K
M
-
I
Y
R
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
-
I
L
N
T
-
I
P
G
G
A
T
A
R
P
F
I
T
H
H
----
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
T
G
G
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
60.36
42%
-63
- C5 -
4UP7
1
?
A:
[12-366]
----------------
Q
L
F
L
N
R
C
K
D
V
E
E
Y
Q
K
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
S
D
D
I
--
V
S
V
A
G
R
V
L
----
S
K
R
----
S
----
S
SSA
L
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
N
-
K
S
A
Y
EN--
K
E
D
F
V
-
S
-
L
-
T
K
M
-
I
Y
R
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
-
I
L
N
T
-
I
P
G
G
A
T
A
R
P
F
I
T
H
H
----
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
T
G
G
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
60.03
42%
-64
- C5 -
4UP9
1
?
A:
[12-378]
----------------
Q
L
F
L
N
R
C
K
D
V
E
E
Y
Q
K
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
S
D
D
I
--
V
S
V
A
G
R
V
L
----
S
K
R
----
S
----
S
SSA
L
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
N
-
K
S
A
Y
EN--
K
E
D
F
V
-
S
-
L
-
T
K
M
-
I
Y
R
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
-
I
L
N
T
-
I
P
G
G
A
T
A
R
P
F
I
T
H
H
----
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
T
G
G
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
58.22
33%
-60
- C5 -
3G1Z
4
EPMA_SALTY
A:
[20-321]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
A
-
T
V
T
D
I
H
L
F
P
F
E
T
R
F
VG---
S
Q
G
I
N
L
Y
L
M
T
S
P
E
Y
H
M
K
R
L
L
A
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
G
R
H
H
N
P
E
F
T
M
L
E
W
Y
R
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
----
Q
Q
V
L
D
C
--------------------
Q
P
A
E
S
L
S
-
Y
Q
Q
A
F
Q
-----------
R
H
L
E
I
D
P
L
S
A
D
K
T
Q
L
R
E
A
A
---
A
K
L
D
L
S
N
I
A
D
T
----
E
E
D
R
D
T
L
L
Q
L
L
F
T
M
G
V
E
P
H
I
GK
E
K
P
T
F
I
Y
H
F
P
A
S
Q
A
S
-
L
A
Q
I
S
T
E
D
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
-
A
R
-
L
P
Q
Q
P
I
D
Q
N
L
L
D
A
L
A
A
G
L
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
S
L
A
D
V
I
A
F
-------
57
PsiBlast_CBE
58.11
33%
-61
- C5 -
3A5Y
1
EPMA_ECOLI
C:
[39-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
A
-
T
V
T
D
I
H
L
V
P
F
E
T
R
F
VGP----
G
M
N
L
W
L
M
T
S
P
E
Y
H
M
K
R
L
L
V
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
G
R
Y
H
N
P
E
F
T
M
L
E
W
Y
R
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
----
Q
Q
V
L
---
D
C
P
A
------
A
E
S
L
--
S
Y
Q
Q
A
F
L
R
Y
L
E
I
D
P
L
S
A
----------------------
D
K
T
Q
L
R
E
V
---
A
A
K
L
D
L
S
---------
E
D
R
D
T
L
L
Q
L
L
F
T
F
G
V
E
P
N
I
GK
E
K
P
T
F
V
Y
H
F
P
A
S
Q
A
S
-
L
A
Q
I
S
T
E
D
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
-
A
R
G
L
P
Q
H
P
I
D
Q
N
L
I
E
A
L
K
V
G
M
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
T
L
A
E
V
I
A
F
-------
58
PsiBlast_CBE
57.91
33%
-58
- C5 -
3A5Y
1
EPMA_ECOLI
B:
[39-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
A
-
T
V
T
D
I
H
L
V
P
F
E
T
R
F
VGPG
H
S
Q
G
M
N
L
W
L
M
T
S
P
E
Y
H
M
K
R
L
L
V
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
G
R
Y
H
N
P
E
F
T
M
L
E
W
Y
R
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
----
Q
Q
V
L
---
D
C
P
A
------
A
E
S
L
--
S
Y
Q
Q
A
F
L
R
Y
L
E
I
D
P
L
S
A
----------------------
D
K
T
Q
L
R
E
-------------------
E
E
D
R
D
T
L
L
Q
L
L
F
T
F
G
V
E
P
N
I
GK
E
K
P
T
F
V
Y
H
F
P
A
S
Q
A
S
-
L
A
Q
I
S
T
E
D
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
-
A
R
G
L
P
Q
H
P
I
D
Q
N
L
I
E
A
L
K
V
G
M
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
T
L
A
E
V
I
A
F
-------
60
PsiBlast_CBE
57.33
33%
-61
- C5 -
3G1Z
5
EPMA_SALTY
B:
[20-321]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
A
-
T
V
T
D
I
H
L
F
P
F
E
T
R
F
VGP---
Q
G
I
N
L
Y
L
M
T
S
P
E
Y
H
M
K
R
L
L
A
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
G
R
H
H
N
P
E
F
T
M
L
E
W
Y
R
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
----
Q
Q
V
L
D
C
--------------------
Q
P
A
E
S
L
S
-
Y
Q
Q
A
F
Q
-----------
R
H
L
E
I
D
P
L
S
A
D
K
T
Q
L
R
E
A
A
---
A
K
L
D
L
----------
E
E
D
R
D
T
L
L
Q
L
L
F
T
M
G
V
E
P
H
I
GK
E
K
P
T
F
I
Y
H
F
P
A
S
Q
A
S
-
L
A
Q
I
S
T
E
D
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
----
R
G
L
P
Q
Q
P
I
D
Q
N
L
L
D
A
L
A
A
G
L
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
S
L
A
D
V
I
A
F
-------
92
HHSearch
57.00
33%
-61
* C5 *
3A5Y
1
EPMA_ECOLI
A:
[29-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
A
S
I
P
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
-
C
M
S
Q
A
T
V
T
D
I
H
L
V
P
F
E
T
R
F
VGPG
H
S
Q
G
M
N
L
W
L
M
T
S
P
E
Y
H
M
K
R
L
L
V
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
G
R
Y
H
N
P
E
F
T
M
L
E
W
Y
R
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
P
A
A
------------------------
E
S
L
S
Y
Q
Q
A
F
L
R
-----------
Y
L
E
I
D
P
L
S
A
D
--------------------------------
T
L
L
Q
L
L
F
T
F
G
V
E
P
N
I
GK
E
K
P
T
F
V
Y
H
F
P
A
S
Q
A
S
-
L
A
Q
I
S
T
E
D
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
A
R
G
L
P
-
Q
H
P
I
D
Q
N
L
I
E
A
L
K
V
G
M
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
T
L
A
E
V
I
A
F
S
V
D
R
---
59
PsiBlast_CBE
56.65
33%
-63
- C5 -
3A5Y
1
EPMA_ECOLI
A:
[39-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
A
-
T
V
T
D
I
H
L
V
P
F
E
T
R
F
VGPG
H
S
Q
G
M
N
L
W
L
M
T
S
P
E
Y
H
M
K
R
L
L
V
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
G
R
Y
H
N
P
E
F
T
M
L
E
W
Y
R
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
----
Q
Q
V
L
---
D
C
P
A
------
A
E
S
L
--
S
Y
Q
Q
A
F
L
R
Y
L
E
I
D
P
L
S
A
----------------------
D
------------------------------
T
L
L
Q
L
L
F
T
F
G
V
E
P
N
I
GK
E
K
P
T
F
V
Y
H
F
P
A
S
Q
A
S
-
L
A
Q
I
S
T
E
D
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
-
A
R
G
L
P
Q
H
P
I
D
Q
N
L
I
E
A
L
K
V
G
M
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
T
L
A
E
V
I
A
F
-------