@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3751: (2016-02-20 )
MTRIGTPLSPSATRVLLCGSGELGKEVAIELQRLGCEVIAVDRYGNAPAMQVAHRSHVISMLDGAALRAVIEQEKPHYIVPEIEAIATATLVELEAEGYTVVPTARAAQLTMNREGIRRLAAEELGLPTSPYHFADTFEDYRRGVERVGYPCVVKPIMSSSGKGQSVLKGPDDLQAAWDYAQEGGRAGKGRVIVEGFIDFDYEITLLTVRHVDGTTFCAPIGHRQVKGDYHESWQPQAMSAQALAESERVARAVTEALGGRGLFGVELFVKGDQVWFSEVSPRPHDTGLVTLISQDLSEFALHARAILGLPIPVIRQLGPSASAVILVEGKSRQVAFANLGAALSEADTALRLFGKPEVDGQRRMGVALARDESIDAARAKATRAAQAVRVEL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120........130.......140.......150.......160.......170.......180.......190.......200--........210..-----.....220-........230.......240.......250.......260.......270.......280.......290.--...--...300.......310.--------....-----.---.320.......330.......340.......350.......360.......370.......380.......390.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTRIGTPLSPSA
T
R
V
L
L
CGSGEL
G
K
E
V
A
I
E
L
Q
R
LG
C
E
V
I
A
V
DRYGNA
P
A
M
Q
V
A
H
R
S
H
V
I
S
M
L
D
G
A
A
L
R
A
V
I
EQEKP
H
Y
IV
P
E
I
E
A
I
A
T
A
T
L
V
E
L
EAEG
Y
T
V
VPTA
R
A
A
Q
L
TM
N
R
E
G
I
R
R
L
-
A
A
E
ELGLPTSP
Y
H
F
A
D
T
F
E
D
Y
R
R
G
V
E
RVGY
P
C
V
V
K
P
I
MSSSGKGQSVLKGP
D
D
L
Q
A
A
W
D
Y
A
Q
EGGRAGK
G
R
V
I
V
E
G
F
IDF
D
---
Y
E
I
T
L
L
T
V
R
HVDG-----
T
T
F
C
API--GHRQVKGDYHESWQPQ
A
M
S
A
Q
A
L
A
E
S
E
R
V
A
R
A
V
T
E
A
LGGRG
L
F
G
V
E
L
F
V
KGD
Q
V
W
F
S
EVSPRPHD
T
G
L
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
A
R
A
ILGL
P
I
P
--------
V
I
R
Q-----L---GPSA
S
A
V
I
L
V
EGKS
R
Q
V
A
F
A
N
LG
A
A
L
S
E
A
D
T
A
L
RLFGKPEVDGQRRM
G
V
A
LARDESI
D
A
A
R
A
K
A
TRA
A
Q
A
V
R
VEL
22
PsiBlast_CBE
90.89
68%
-98
- C3 -
1EYZ
5
PURT_ECOLI
B:
[2-391]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
G
--
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
-
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-
1
PsiBlast_PDB
90.76
68%
-97
- C3 -
1EYZ
8
PURT_ECOLI
A:
[2-391]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
G
--
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
-
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-
23
PsiBlast_CBE
90.54
68%
-102
- C3 -
1KJQ
13
PURT_ECOLI
B:
[1-390]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
----
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
--
A
G
A
G
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
-
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-
2
PsiBlast_PDB
90.48
68%
-99
- C3 -
1EZ1
7
PURT_ECOLI
A:
[2-391]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
G
--
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
-
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-
25
PsiBlast_CBE
90.44
68%
-98
- C3 -
1KJI
6
PURT_ECOLI
B:
[1-390]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
--
G
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
-
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-
5
PsiBlast_PDB
90.26
68%
-98
- C3 -
1KJI
8
PURT_ECOLI
A:
[1-390]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
--
G
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
-
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-
24
PsiBlast_CBE
89.84
68%
-101
- C3 -
1KJJ
4
PURT_ECOLI
B:
[1-390]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
------
G
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
-
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-
61
Fugue
89.80
67%
-97
* C3 *
1EZ1
7
PURT_ECOLI
A:
[2-392]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
--
A
G
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
-
V
Q
N
A
V
G
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
G
21
PsiBlast_CBE
89.69
68%
-96
- C3 -
1EZ1
8
PURT_ECOLI
B:
[2-391]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
G
--
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
-
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-
27
PsiBlast_CBE
89.60
68%
-103
- C3 -
1KJ8
10
PURT_ECOLI
B:
[1-390]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
-------
G
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
-
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-
4
PsiBlast_PDB
89.57
68%
-100
- C3 -
1KJ9
14
PURT_ECOLI
A:
[1-390]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
-----
G
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
-
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-
6
PsiBlast_PDB
89.46
68%
-98
- C3 -
1KJJ
6
PURT_ECOLI
A:
[1-390]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
-----
G
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
-
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-
3
PsiBlast_PDB
89.44
68%
-99
- C3 -
1KJ8
11
PURT_ECOLI
A:
[1-390]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
-----
G
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
-
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-
41
HHSearch
89.25
68%
-101
- C3 -
1KJQ
17
PURT_ECOLI
A:
[1-390]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
---
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
G
A
G
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
-
G
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-
7
PsiBlast_PDB
89.24
68%
-101
- C3 -
1KJQ
17
PURT_ECOLI
A:
[1-390]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
---
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
G
A
G
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
-
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-
26
PsiBlast_CBE
88.90
68%
-100
- C3 -
1KJ9
6
PURT_ECOLI
B:
[1-390]
-
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
-
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
----
G
R
V
I
V
E
G
V
V
K
F
D
---
F
E
I
T
L
L
T
V
S
A
V
D
G
-----
V
H
F
C
A
P
V
--
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
--
S
Q
D
--
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
--------
G
I
R
Q
-----
Y
---
G
P
A
A
S
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
-
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-
28
PsiBlast_CBE
83.27
50%
-104
- C3 -
2DWC
2
PURT_PYRHO
B:
[11-413]
---
L
G
T
A
T
T
D
S
A
Q
K
I
L
L
L
G
S
G
E
L
G
K
E
I
A
I
E
A
Q
R
L
G
V
E
V
V
A
V
D
R
Y
A
N
A
P
A
M
Q
V
A
H
R
S
Y
V
G
N
M
M
D
K
D
F
L
W
S
V
V
E
R
E
K
P
D
A
I
I
P
E
I
E
A
I
N
L
D
A
L
F
E
F
E
K
D
G
Y
F
V
V
P
N
A
R
A
T
W
I
A
M
H
R
E
R
L
R
E
T
-
L
V
K
E
A
K
V
P
T
S
R
Y
M
Y
A
T
T
L
D
E
L
Y
E
A
C
E
K
I
G
Y
P
C
H
T
K
A
I
M
S
----
G
S
Y
F
V
K
G
P
E
D
I
P
K
A
W
E
E
---------
E
K
I
I
V
E
E
H
I
D
F
D
---
V
E
V
T
E
L
A
V
R
H
F
D
E
NG
E
I
V
T
T
F
P
K
P
V
--
G
H
Y
Q
I
D
G
D
Y
H
A
S
W
Q
P
A
E
I
S
E
K
A
E
R
E
V
Y
R
I
A
K
R
I
T
D
V
L
G
G
L
G
I
F
G
V
E
M
F
V
K
G
D
K
V
W
A
N
E
V
S
P
R
P
H
D
T
G
M
V
T
L
A
--
S
H
P
PG
F
S
E
F
A
L
H
L
R
A
V
L
G
L
P
I
P
G
E
W
V
DGYR
L
F
P
M
-----
L
---
I
P
A
A
T
H
V
I
K
A
K
V
S
G
Y
S
P
R
F
R
G
L
V
K
A
L
S
V
P
N
A
T
V
R
L
F
G
K
P
E
A
Y
V
G
R
R
L
G
I
A
L
A
W
D
K
D
V
E
V
A
K
R
K
A
E
M
V
A
H
M
I
E
L
--
9
PsiBlast_PDB
83.12
50%
-103
- C3 -
2DWC
2
PURT_PYRHO
A:
[11-413]
---
L
G
T
A
T
T
D
S
A
Q
K
I
L
L
L
G
S
G
E
L
G
K
E
I
A
I
E
A
Q
R
L
G
V
E
V
V
A
V
D
R
Y
A
N
A
P
A
M
Q
V
A
H
R
S
Y
V
G
N
M
M
D
K
D
F
L
W
S
V
V
E
R
E
K
P
D
A
I
I
P
E
I
E
A
I
N
L
D
A
L
F
E
F
E
K
D
G
Y
F
V
V
P
N
A
R
A
T
W
I
A
M
H
R
E
R
L
R
E
T
-
L
V
K
E
A
K
V
P
T
S
R
Y
M
Y
A
T
T
L
D
E
L
Y
E
A
C
E
K
I
G
Y
P
C
H
T
K
A
I
M
S
------
Y
F
V
K
G
P
E
D
I
P
K
A
W
E
E
---------
E
K
I
I
V
E
E
H
I
D
F
D
---
V
E
V
T
E
L
A
V
R
H
F
D
E
NG
E
I
V
T
T
F
P
K
P
V
--
G
H
Y
Q
I
D
G
D
Y
H
A
S
W
Q
P
A
E
I
S
E
K
A
E
R
E
V
Y
R
I
A
K
R
I
T
D
V
L
G
G
L
G
I
F
G
V
E
M
F
V
K
G
D
K
V
W
A
N
E
V
S
P
R
P
H
D
T
G
M
V
T
L
A
--
S
H
P
PG
F
S
E
F
A
L
H
L
R
A
V
L
G
L
P
I
P
G
E
W
V
DGYR
L
F
P
M
-----
L
---
I
P
A
A
T
H
V
I
K
A
K
V
S
G
Y
S
P
R
F
R
G
L
V
K
A
L
S
V
P
N
A
T
V
R
L
F
G
K
P
E
A
Y
V
G
R
R
L
G
I
A
L
A
W
D
K
D
V
E
V
A
K
R
K
A
E
M
V
A
H
M
I
E
L
--
8
PsiBlast_PDB
82.27
50%
-103
- C3 -
2CZG
10
PURT_PYRHO
A:
[11-413]
---
L
G
T
A
T
T
D
S
A
Q
K
I
L
L
L
G
S
G
E
L
G
K
E
I
A
I
E
A
Q
R
L
G
V
E
V
V
A
V
D
R
Y
A
N
A
P
A
M
Q
V
A
H
R
S
Y
V
G
N
M
M
D
K
D
F
L
W
S
V
V
E
R
E
K
P
D
A
I
I
P
E
I
E
A
I
N
L
D
A
L
F
E
F
E
K
D
G
Y
F
V
V
P
N
A
R
A
T
W
I
A
M
H
R
E
R
L
R
E
T
-
L
V
K
E
A
K
V
P
T
S
R
Y
M
Y
A
T
T
L
D
E
L
Y
E
A
C
E
K
I
G
Y
P
C
H
T
K
A
I
M
S
------
Y
F
V
K
G
P
E
D
I
P
K
A
W
-----------
E
K
I
I
V
E
E
H
I
D
F
D
---
V
E
V
T
E
L
A
V
R
H
F
D
E
NG
E
I
V
T
T
F
P
K
P
V
--
G
H
Y
Q
I
D
G
D
Y
H
A
S
W
Q
P
A
E
I
S
E
K
A
E
R
E
V
Y
R
I
A
K
R
I
T
D
V
L
G
G
L
G
I
F
G
V
E
M
F
V
K
G
D
K
V
W
A
N
E
V
S
P
R
P
H
D
T
G
M
V
T
L
A
--
S
H
P
PG
F
S
E
F
A
L
H
L
R
A
V
L
G
L
P
I
P
G
E
W
V
DGYR
L
F
P
M
-----
L
---
I
P
A
A
T
H
V
I
K
A
K
V
S
G
Y
S
P
R
F
R
G
L
V
K
A
L
S
V
P
N
A
T
V
R
L
F
G
K
P
E
A
Y
V
G
R
R
L
G
I
A
L
A
W
D
K
D
V
E
V
A
K
R
K
A
E
M
V
A
H
M
I
E
L
--
42
HHSearch
79.29
50%
-99
- C3 -
2DWC
3
PURT_PYRHO
A:
[11-414]
---
L
G
T
A
T
T
D
S
A
Q
K
I
L
L
L
G
S
G
E
L
G
K
E
I
A
I
E
A
Q
R
L
G
V
E
V
V
A
V
D
R
Y
A
N
A
P
A
M
Q
V
A
H
R
S
Y
V
G
N
M
M
D
K
D
F
L
W
S
V
V
E
R
E
K
P
D
A
I
I
P
E
I
E
A
I
N
L
D
A
L
F
E
F
E
K
D
G
Y
F
V
V
P
N
A
R
A
T
W
I
A
M
H
R
E
R
L
R
E
T
L
V
-
K
E
A
K
V
P
T
S
R
Y
M
Y
A
T
T
L
D
E
L
Y
E
A
C
E
K
I
G
Y
P
C
H
T
K
A
I
M
S
------
Y
F
V
K
G
P
E
D
I
P
K
A
W
E
E
---------
E
K
I
I
V
E
E
H
I
D
F
D
V
E
V
T
E
L
A
V
R
H
F
D
E
N
G
E
-----
I
V
T
T
F
P
K
P
V
G
H
Y
Q
I
D
G
D
Y
H
A
S
W
Q
P
A
E
I
S
E
K
A
E
R
E
V
Y
R
I
A
K
R
I
T
D
V
L
G
G
L
G
I
F
G
V
E
M
F
V
K
G
D
K
V
W
A
N
E
V
S
P
R
P
H
D
T
G
M
V
T
L
A
SH
P
P
G
--
F
S
E
F
A
L
H
L
R
A
V
L
G
L
P
I
P
--------
G
E
W
V
DGYR
L
F
P
M
L
I
P
A
A
T
H
V
I
K
A
K
V
S
G
Y
S
P
R
F
R
G
L
V
K
A
L
S
V
P
N
A
T
V
R
L
F
G
K
P
E
A
Y
V
G
R
R
L
G
I
A
L
A
W
D
K
D
V
E
V
A
K
R
K
A
E
M
V
A
H
M
I
E
L
R
-