@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3810: (2016-02-21 )
MALLQIAEPGQSPKPHERRLAVGIDLGTTNSLVAAVRSGVAEPLPDAQGRLILPSAVRYHAERAEVGESARAAAAEDPFNTVISVKRLMGRGLEDVKQLGEQLPYRFRQGESHMPFIETVQGLKSPVEVSADILRELRQRAETTLGGELVGAVITVPAYFDDAQRQATKDAARLAGLNVLRLLNEPTAAAVAYGLDKGAEGLVAIYDLGGGTFDISILRLTRGVFEVLATGGDTALGGDDFDHAIAGWVIEQAGLSADLDPGSQRQLLQIACAAKERLTDEASVRVAYGDWSGELSRATLDELIEPFVARSLKSCRRAVRDSGVDLEEIRSVVMVGGSTRVPRVRTAVGELFGCEPLTDIDPDQVVAIGAAIQADALAGNKRGEELLLLDVIPLSLGLETMGGLMEKVIPRNTTIPVARAQEFTTYKDGQTAMMIHVLQGERELVKDCRSLARFELRGIPPMVAGAAKIRVTFQVDADGLLGVSARELSSGVEASIQVKPSYGLTDGEIARMLKDSFDYAGDDKAARALREQQVEAQRLLEAVQSALDVDGERLLDEEERLAIAAQMDTLRELAGGSDTAAIENQIKRLSQVTDAFAARRMDATVKAALSGRRLNEIEE
Atome Classification :
(91 SA)
.........10........20........30........40........50........60.-...-....70........80........90....--....100.-...-.------------..-110.....------------..-.----120--..-----..---.---..---..130.......140.......150.......160.......170.......180.......190.....-------.-------.200-........210.......220---.----.......230.......240.......250--.-----.----...----..----..260......---..270.-.....---.280......--..------.------290--------...------.----------.....300.......310.......320.......330.......340.......350-.-.....-.360.......370.......380-........390.......400----..----.....410.......420.......430...-....440.......450.......460..-.....470.......480....----..---.490.......500..-......510.......520.......530.......540.......550.......560.......570..----....----.580.......590.......600.......610.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
L
L
QIAEPGQSPKPHE
R
R
L
A
V
G
I
DLGT
T
N
S
L
V
A
A
V
R
SGVAEPLPDAQG
R
L
I
L
P
S
A
V
R
Y
H
A
E
-
R
A
E-VG
E
S
ARAAAAED
P
F
N
T
V
I
S
V
K
R
L
M
GR
G
L
E
D
--
V
K
Q
L
G
E
QL-
P
Y
R
-F------------RQ-GE-SHM
P
F
------------
I
E
-
T
----
V
----
Q
G-----LK---S---
P
V
---
E
V
S
A
D
I
L
R
E
L
R
Q
R
A
E
TTLGG
E
L
V
G
A
V
I
T
VPAYF
D
D
A
Q
R
Q
A
T
K
D
A
A
R
L
A
G
L
N
V
L
R
L
LNEP
T
A
A
A
V
A
YGLDK-------G-------AE
G
--
L
V
A
I
Y
DLGG
G
T
F
D
I
S
I
L
R
L
T
----
R
----
G
V
F
E
V
L
ATGGDTALGGD
D
F
D
H
A
I
A
G
W
V
I
----
E
-----Q----AGL----SA----DLD-PG
S
Q
R
Q
L
---
L
Q
I
A
C
A
-
A
K
E
RL---TD--EA
S
V
R
V
--
A
Y
------G------D----------WSG------E----------
L
S
R
A
T
L
D
E
L
I
E
P
F
V
A
R
S
L
K
S
C
R
R
A
V
R
DSGV
D
L
E
E
I
R
S
V
V
MVGGSTRV
P
R
V
R
T
A
V
G
E
L
F-G-CEPLT-DIDPD
Q
V
V
A
IG
A
A
I
Q
A
D
ALAGNK--RG
E
E
L
L
L
L
D
VI
P
L
S
L
G
L
E
T
M
G
----
G
L
----
M
E
K
VIPRNTTIPVARAQEFTTYKDG
Q
T
A
M
M
I
-
H
VLQG
E
R
E
L
V
K
D
C
R
S
L
A
R
F
E
LRGIPPMVA-G
A
A
K
I
R
V
T
F
Q
VDADG
L
L
GV
S
A
R
----
E
L
---SSGV
E
A
S
I
Q
V
KP-SYG-L
T
D
G
E
I
A
R
M
L
K
D
SFDYAG
D
D
K
A
A
R
A
L
R
E
Q
Q
V
E
A
Q
R
L
L
E
A
V
Q
S
A
LDVD
G
E
R
LL
D
E
E
E
R
L
A
I
A
A
Q
M
D
T
L
R
E
L
A----GGS
D
----
T
A
A
I
E
N
Q
I
K
R
L
S
Q
V
T
D
A
F
A
A
R
R
M
D
A
T
V
K
A
A
LSGRRLNEIEE
22
PsiBlast_CBE
96.01
41%
-78
- C5 -
4JN4
12
DNAK_ECOLI
B:
[5-591]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
-
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
EE
V
Q
R
D
V
S
I
M
-
P
F
K
-
I
------------
I
A
-
A
D
-
N
G
D
A
W
------------
V
E
------
V
----
K
G
-----
Q
K
M--
A
---
P
P
---
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
-------
G
-------
T
G
N
R-
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
EVDG
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
----
E
-----
E
FKKD
Q
G
I
----
D
L
----
R
N
D
-
P
L
A
M
Q
R
L
---
K
E
A
A
E
K
-
A
K
I
E
L
---
S
S
AQ
Q
T
D
V
N
L
--
P
Y
IT----
A
------
D
----------
A
T
G
PKHMNI
K
----------
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
-
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
V
--
K
--
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
----
G
G
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
---
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
-
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
----
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
--------------------------
3
PsiBlast_PDB
95.91
41%
-78
- C5 -
4JN4
12
DNAK_ECOLI
A:
[5-591]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
-
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
V
Q
R
D
V
S
I
M
-
P
F
K
-
I
------------
I
A
-
A
D
-
N
G
D
A
W
------------
V
E
------
V
----
K
G
-----
Q
K
M
--
A
---
P
P
---
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
-------
G
-------
T
G
N
R
-
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
DG
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
----
E
-----
E
F
K
K
D
Q
G
I
----
D
L
----
R
N
D
-
P
L
A
M
Q
R
L
---
K
E
A
A
E
K
-
A
K
I
E
L
---
S
S
AQ
Q
T
D
V
N
L
--
P
Y
IT----
A
------
D
----------
A
T
G
P
K
H
M
N
I
K
----------
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
-
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
V
--
K
--
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
----
G
G
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
---
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
-
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
----
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
--------------------------
2
PsiBlast_PDB
95.52
41%
-79
- C5 -
4B9Q
1
DNAK_ECOLI
A:
[5-595]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
-
G
C
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
V
Q
R
D
V
S
I
M
-
P
F
K
-
I
------------
I
A
-
A
D
-
N
G
D
A
W
------------
V
E
------
V
----
K
G
-----
Q
K
M
--
A
---
P
P
---
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
-------
G
-------
T
G
N
R
-
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
----
E
V
DG
E
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
----
E
-----
E
F
K
K
D
Q
G
I
----
D
L
----
R
N
D
-
P
L
A
M
Q
R
L
---
K
E
A
A
E
K
-
A
K
I
E
L
---
S
S
AQ
Q
T
D
V
N
L
--
P
Y
IT----
A
------
D
----------
A
T
G
P
K
H
M
N
I
K
----------
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
-
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
V
--
K
--
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
---
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
C
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
-
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
----
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
--------------------------
21
PsiBlast_CBE
95.43
41%
-76
- C5 -
4JNE
11
DNAK_ECOLI
B:
[5-591]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
-
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
EE
V
Q
R
D
V
S
I
M
-
P
F
K
-
I
------------
I
A
-
A
D
-
N
G
D
A
W
------------
V
E
------
V
----
K
G
-----
Q
K
M--
A
---
P
P
---
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
-------
G
-------
T
G
N
R-
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
EVDG
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
----
E
-----
E
FKKD
Q
G
I
----
D
L
----
R
N
D
-
P
L
A
M
Q
R
L
---
K
E
A
A
E
K
-
A
K
I
E
L
---
S
S
AQ
Q
T
D
V
N
L
--
P
Y
IT----
A
------
D
----------
A
T
G
PKHMNI
K
----------
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
-
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
V
--
K
--
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
----
G
G
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
---
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
-
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
----
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
--------------------------
4
PsiBlast_PDB
94.91
41%
-77
- C5 -
4JNE
12
DNAK_ECOLI
A:
[5-591]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
-
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
V
Q
R
D
V
S
I
M
-
P
F
K
-
I
------------
I
A
-
A
D
-
N
G
D
A
W
------------
V
E
------
V
----
K
G
-----
Q
K
M
--
A
---
P
P
---
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
-------
G
-------
T
G
N
R
-
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
DG
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
----
E
-----
E
F
K
K
D
Q
G
I
----
D
L
----
R
N
D
-
P
L
A
M
Q
R
L
---
K
E
A
A
E
K
-
A
K
I
E
L
---
S
S
AQ
Q
T
D
V
N
L
--
P
Y
IT----
A
------
D
----------
A
T
G
P
K
H
M
N
I
K
----------
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
-
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
V
--
K
--
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
----
G
G
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
---
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
-
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
----
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
--------------------------
1
PsiBlast_PDB
93.97
42%
-82
- C5 -
2KHO
-
DNAK_ECOLI
A:
[5-595]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
-
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
V
Q
R
D
V
S
I
M
-
P
F
K
-
I
------------
I
A
-
A
D
-
N
G
D
A
W
------------
V
E
------
V
----
K
G
-----
Q
K
M
--
A
---
P
P
---
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
-------
G
-------
T
G
N
R
-
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
D
----
E
VDGE
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
----
E
-----
E
F
K
K
D
Q
G
I
----
D
L
----
R
N
D
-
P
L
A
M
Q
R
L
---
K
E
A
A
E
K
-
A
K
I
E
L
---
S
S
AQ
Q
T
D
V
N
L
--
P
Y
IT----
A
------
D
----------
A
T
G
P
K
H
M
N
I
K
----------
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
-
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
V
--
K
--
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
---
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
D
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
-
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
----
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
--------------------------
102
HHSearch
89.12
47%
-84
- C6 -
2V7Y
2
DNAK_GEOKA
A:
[2-504]
------------------
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
K
N
G
-
E
R
L
-
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
T
D
Y
K
----------------------------------------------------
V
E
-
I
----
E
----
G
K
-----
Q
Y
---
T
---
P
Q
---
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
-------
E
-------
E
D
Q
--
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
G
----
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
----
N
-----
Q
----
F
K
Q
----
E
H
GIDL
S
K
D
-
K
M
A
L
Q
R
L
---
K
D
A
A
E
K
-
A
K
K
E
L
---
S
G
--
V
T
Q
T
Q
I
--
S
L
------
P
------
F
ISANEN
G
P
L
H
L
E
M
------
T
----------
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
E
P
H
K
-
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
-
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
----
D
L
---
G
T
N
K
E
Q
S
I
T
I
K
S
-
S
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
-----------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.08
44%
-85
- C6 -
2V7Y
2
DNAK_GEOKA
A:
[5-504]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
K
N
G
-
E
R
L
-
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
T
D
Y
K
---
V
E
I
E
G
K
Q
Y
------------------------------------------------------------------
T
---
P
Q
---
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
-------
E
-------
E
D
Q
--
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
G
----
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
----
N
-----
Q
F
K
Q
E
H
G
I
----
D
L
----
S
K
D
-
K
M
A
L
Q
R
L
---
K
D
A
A
E
K
-
A
K
K
E
L
---
S
G
--
V
T
Q
T
Q
I
--
S
L
------
P
------
F
----------
I
S
A
------
N
EN
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
E
P
H
K
-
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
V
--
K
--
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
-
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
----
D
L
---
G
T
N
K
E
Q
S
I
T
I
K
S
-
S
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
-----------------------------------------------------------------------------------------------
6
PsiBlast_PDB
87.59
44%
-88
- C6 -
4ANI
-
DNAK_GEOKA
C:
[5-508]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
K
N
G
-
E
R
L
-
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
T
D
Y
K
---
V
E
I
E
G
K
Q
Y
------------------------------------------------------------------
T
---
P
Q
---
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
-------
E
-------
E
D
Q
--
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
G
----
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
----
N
-----
Q
F
K
Q
E
H
G
I
----
D
L
----
S
K
D
-
K
M
A
L
Q
R
L
---
K
D
A
A
E
K
-
A
K
K
E
L
---
S
G
--
V
T
Q
T
Q
I
--
S
L
------
P
------
F
----------
I
S
A
------
N
EN
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
E
P
H
K
-
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
V
--
K
--
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
-
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
----
D
L
---
G
T
N
K
E
Q
S
I
T
I
K
S
-
S
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
R
N
E
A
-------------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.92
41%
-79
- C5 -
1YUW
-
HSP7C_BOVIN
A:
[6-544]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
----------
V
-
V
------------
Q
S
-
D
M
-
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
A
----
A
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
SE
N
V
Q
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
----
G
V
----
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
-
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
----
D
K
---
S
T
G
K
E
N
K
I
T
I
T
N
-
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
----
D
K
V
S
S
K
N
S
L
E
S
-------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.87
41%
-88
- C5 -
3C7N
9
HSP7C_BOVIN
B:
[6-544]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
----------
V
-
V
------------
Q
S
-
D
M
-
K
H
W
P
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
-----
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
----
G
V
----
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
-
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
----
D
K
---
S
T
G
K
E
N
K
I
T
I
T
N
-
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
----
D
K
V
S
S
K
N
S
L
E
S
-------------------------------------------------------------------------------------
20
PsiBlast_PDB
79.39
40%
-82
- C5 -
3KVG
4
?
A:
[21-399]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
W
R
N
D
T
V
D
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
E
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
R
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
K
F
D
D
Q
A
V
Q
S
D
M
T
H
W
-
P
F
K
-
V
------------
V
R
-
G
P
-
K
D
K
P
I
------------
I
S
V
N
----
Y
----
L
G
-----
E
K
---
K
---
E
F
H
A
E
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-------
K
-------
G
T
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
E
----
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
E
F
C
V
----
Q
D
F
K
R
K
N
----
R
G
M
----
D
L
----
T
T
N
-
A
R
A
L
R
R
L
---
R
T
Q
C
E
R
-
A
K
R
T
L
---
S
S
--
S
T
Q
A
T
I
--
E
L
------
D
SLYEG
I
D
----------
Y
S
V
------
A
----------
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
R
A
T
L
A
P
V
E
K
V
L
K
D
A
G
M
D
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
A
L
I
Q
E
F
F
N
G
-
K
E
P
C
K
-
A
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
N
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
79.14
40%
-82
- C5 -
3KVG
4
?
B:
[21-399]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
W
R
N
D
T
V
D
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
E
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
R
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
K
F
D
D
QA
V
Q
S
D
M
T
H
W
-
P
F
K
-
V
------------
V
R
-
G
P
-
K
D
K
P
I
------------
I
S
V
N
----
Y
----
L
G
-----
E
K
---
K
---
E
F
HAE
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-------
K
-------
G
T
G
ER
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
E
----
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
E
F
C
V
----
Q
DFKRK
N
----
R
G
M
----
D
L
----
T
T
N
-
A
R
A
L
R
R
L
---
R
T
Q
C
E
R
-
A
K
R
T
L
---
S
S
--
S
T
Q
A
T
I
--
E
L
------
D
SLYEGI
D
----------
Y
S
V
------
A
----------
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
R
A
T
L
A
P
V
E
K
V
L
K
D
A
G
M
D
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
A
L
I
Q
E
F
F
N
G
-
K
E
P
C
K
-
A
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
N
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
78.44
40%
-88
- C5 -
3L4I
3
?
A:
[21-399]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
W
R
N
D
T
V
D
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
E
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
R
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
K
F
D
D
Q
A
V
Q
S
D
M
T
H
W
-
P
F
K
-
V
------------
V
R
-
G
P
-
K
D
K
P
I
------------
I
S
V
N
----
Y
----
L
G
-----
E
K
---
K
---
E
F
H
A
E
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-------
K
-------
G
T
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
E
----
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
E
F
C
V
----
Q
D
F
K
R
K
N
----
R
G
M
----
D
L
----
T
T
N
-
A
R
A
L
R
R
L
---
R
T
Q
C
E
R
-
A
K
R
T
L
---
S
S
--
S
T
Q
A
T
I
--
E
L
------
D
SLYEG
I
D
----------
Y
S
V
------
A
----------
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
R
A
T
L
A
P
V
E
K
V
L
K
D
A
G
M
D
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
A
L
I
Q
E
F
F
N
G
-
K
E
P
C
K
-
A
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
N
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
77.93
21%
-69
- C5 -
3D2F
4
?
A:
[2-636]
------------------
S
T
P
F
G
L
D
L
G
N
N
N
S
V
L
A
V
A
R
N
R
G
I
D
I
V
V
N
E
V
S
N
R
S
T
P
S
V
V
G
F
G
P
K
-
N
R
Y
-
L
G
E
T
G
K
N
K
Q
T
S
N
I
K
N
T
V
A
N
L
K
R
I
I
G
L
D
Y
H
H
PD
F
E
Q
E
S
K
H
F
-
T
S
K
-
L
------------
V
E
-
L
D
-
D
K
K
T
G
------------
A
E
-
V
R
F
AG
E
----
K
H
-----
V
F
---
S
---
A
T
---
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
K
Q
D
T
K
A
N
I
T
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
R
Y
N
I
A
D
A
A
R
I
A
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
F
K
-------
T
DLPEGEE
K
P
R
--
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
K
----
K
----
G
Q
L
K
V
L
G
T
A
C
D
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
F
A
----
D
-----
E
----
F
K
T
----
K
Y
KIDI
R
E
N
-
P
K
A
Y
N
R
I
---
L
T
A
A
E
K
-
L
K
K
V
L
---
S
A
--
N
T
N
A
P
F
--
S
V
------
E
------
S
VMND
V
D
----
V
S
S
------
Q
----------
L
S
R
E
E
L
E
E
L
V
K
P
L
L
E
R
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
A
E
E
V
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
-
G
-
K
P
L
S
T
-
T
L
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
H
S
P
T
L
--
R
V
R
P
F
K
F
E
D
I
H
P
Y
S
V
S
Y
S
W
D
K
QVED
E
D
----
H
M
E
V
F
P
A
G
S
S
F
P
S
T
K
L
I
T
L
N
R
T
G
D
F
S
M
A
A
S
Y
T
D
I
T
Q
L
P
P
---
N
T
P
E
Q
I
A
N
W
E
I
T
G
V
Q
L
P
E
G
Q
D
S
V
P
V
K
L
K
L
R
C
D
P
S
G
L
H
T
I
E
E
A
Y
T
I
E
D
T
---
K
T
V
K
K
D
D
L
T
I
V
A
H
T
F
G
-
L
D
A
K
K
L
N
E
L
I
E
K
E
N
E
M
L
A
Q
D
K
L
V
A
E
T
E
D
R
K
N
T
L
E
E
Y
I
Y
T
L
R
G
K
L
E
E
E
Y
A
P
F
A
S
D
A
E
K
T
K
L
Q
G
M
L
N
K
A
E
E
W
L
----
Y
D
E
G
FDSI
K
A
K
Y
I
A
K
Y
E
E
L
A
S
L
G
N
I
I
R
G
R
Y
L
A
K
E
E
E
K
K
Q
A
I
R
-------
29
PsiBlast_CBE
77.91
40%
-87
- C5 -
3L6Q
4
?
B:
[21-398]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
W
R
N
D
T
V
D
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
E
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
R
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
K
F
D
D
Q
A
V
Q
S
D
M
T
H
W
-
P
F
K
-
V
------------
V
R
-
G
P
-
K
D
K
P
I
------------
I
S
V
N
----
Y
----
L
G
-----
E
K
---
K
---
E
F
H
A
E
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-------
K
---------
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
E
----
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
E
F
C
V
----
Q
D
F
K
R
K
N
----
R
G
M
----
D
L
----
T
T
N
-
A
R
A
L
R
R
L
---
R
T
Q
C
E
R
-
A
K
R
T
L
---
S
S
--
S
T
Q
A
T
I
--
E
L
------
D
SLYEG
I
D
----------
Y
S
V
------
A
----------
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
R
A
T
L
A
P
V
E
K
V
L
K
D
A
G
M
D
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
A
L
I
Q
E
F
F
N
G
-
K
E
P
C
K
-
A
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
77.81
40%
-85
- C5 -
3L6Q
5
?
A:
[21-398]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
W
R
N
D
T
V
D
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
E
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
R
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
K
F
D
D
Q
A
V
Q
S
D
M
T
H
W
-
P
F
K
-
V
------------
V
R
-
G
P
-
K
D
K
P
I
------------
I
S
V
N
----
Y
----
L
G
-----
E
K
---
K
---
E
F
H
A
E
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-------
K
-------
G
T
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
E
----
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
E
F
C
V
----
Q
D
F
K
R
K
N
----
R
G
M
----
D
L
----
T
T
N
-
A
R
A
L
R
R
L
---
R
T
Q
C
E
R
-
A
K
R
T
L
---
S
S
--
S
T
Q
A
T
I
--
E
L
------
D
SLYEG
I
D
----------
Y
S
V
------
A
----------
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
R
A
T
L
A
P
V
E
K
V
L
K
D
A
G
M
D
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
A
L
I
Q
E
F
F
N
G
-
K
E
P
C
K
-
A
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
77.31
41%
-81
- C5 -
3IUC
2
GRP78_HUMAN
A:
[29-404]
---------------------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
-
P
F
K
-
V
------------
V
E
-
K
K
-
T
K
-
P
Y
------------
I
Q
-
V
----
D
----
I
G
GG
Q
T
K
T
F
---
A
---
P
E
---
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R------
E
-------
G
E
K
--
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
D
----
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
-----
K
----
T
G
K
----
D
V
----
R
K
D
-
N
R
A
V
Q
K
L
---
R
R
E
V
E
K
-
A
K
R
A
L
---
S
S
--
Q
H
Q
A
R
I
--
E
I
E
SFYEG
E
------
D
----------
F
S
E
------
T
----------
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
-
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
77.27
41%
-79
- C5 -
3LDN
-
GRP78_HUMAN
A:
[31-407]
---------------------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
-
P
F
K
-
V
------------
V
E
-
K
K
-
T
K
-
P
Y
------------
I
Q
-
V
----
D
----
I
G
GG
Q
T
K
T
F
---
A
---
P
E
---
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R------
E
-------
G
E
K
--
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
D
----
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
-----
K
----
T
G
K
----
D
V
----
R
K
D
-
N
R
A
V
Q
K
L
---
R
R
E
V
E
K
-
A
K
R
A
L
---
S
S
--
Q
H
Q
A
R
I
--
E
I
E
SFYEG
E
------
D
----------
F
S
E
------
T
----------
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
-
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Fugue
76.79
20%
-74
- C5 -
2QXL
3
HSP7F_YEAST
A:
[2-656]
-------------------
T
P
F
G
L
D
L
G
N
N
N
S
V
L
A
V
A
R
N
R
G
I
D
I
V
V
N
E
V
S
N
R
S
T
P
S
V
V
G
F
G
P
K
-
N
R
Y
-
L
G
E
T
G
K
N
K
Q
T
S
N
I
K
N
T
V
A
N
L
K
R
I
I
G
L
D
Y
H
H
PD
F
E
Q
E
S
K
H
F
-
T
S
K
-
L
------------
V
E
-
L
D
-
D
K
K
T
G
------------
A
E
-
V
----
R
F---
A
G
-----
E
K
---
H
---
V
F
S
A
T
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
K
Q
D
T
K
A
N
I
T
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
R
Y
N
I
A
D
A
A
R
I
A
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
F
K
TDLPEGE
E
-------
K
P
R
--
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
K
----
K
----
G
Q
L
K
V
L
G
T
A
C
D
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
F
A
----
D
-----
E
----
F
K
T
K
YKI
D
I
----
R
E
N
-
P
K
A
Y
N
R
I
---
L
T
A
A
E
K
-
L
K
K
V
L
---
S
A
--
N
T
N
A
P
F
--
S
V
------
E
SVMND
V
D
----------
V
S
S
------
Q
----------
L
S
R
E
E
L
E
E
L
V
K
P
L
L
E
R
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
A
E
E
V
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
-
G
-
K
P
L
S
T
-
T
L
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
H
-------
S
R
P
F
K
F
E
D
I
H
P
Y
S
V
S
Y
S
W
D
K
----
Q
V
EDED
H
M
E
V
F
P
A
G
S
S
F
P
S
T
K
L
I
T
L
N
R
T
G
D
F
S
M
A
A
S
Y
-
T
D
I
T
Q
L
P
P
N
T
P
E
--
Q
I
A
N
W
E
I
-------
T
-
D
S
V
P
V
K
L
K
L
R
C
D
P
S
G
L
H
T
I
E
E
A
----
Y
T
I
E
D
K
T
V
K
K
D
D
L
T
I
V
A
H
T
F
G
-
L
D
A
K
K
L
N
E
L
I
E
K
E
N
E
M
L
A
Q
D
K
L
V
A
E
T
E
D
R
K
N
T
L
E
E
Y
I
Y
T
L
R
G
K
L
E
E
E
Y
A
P
F
A
S
D
A
E
K
T
K
L
Q
G
M
L
N
K
A
E
E
W
L
Y
DEG
F
D
S
I
----
K
A
K
Y
I
A
K
Y
E
E
L
A
S
L
G
N
I
I
R
G
R
Y
L
A
K
E
E
E
K
K
Q
A
I
R
S
K
Q
----
19
PsiBlast_PDB
76.68
41%
-80
- C5 -
3LDP
1
GRP78_HUMAN
A:
[8-383]
---------------------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
-
P
F
K
-
V
------------
V
E
-
K
K
-
T
K
-
P
Y
------------
I
Q
-
V
----
D
----
I
G
GG
Q
T
K
T
F
---
A
---
P
E
---
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R------
E
-------
G
E
K
--
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
D
----
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
-----
K
----
T
G
K
----
D
V
----
R
K
D
-
N
R
A
V
Q
K
L
---
R
R
E
V
E
K
-
A
K
R
A
L
---
S
S
--
Q
H
Q
A
R
I
--
E
I
E
SFYEG
E
------
D
----------
F
S
E
------
T
----------
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
-
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
76.66
41%
-78
- C5 -
3IUC
3
GRP78_HUMAN
C:
[29-406]
---------------------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
PS
V
Q
Q
D
I
K
F
L
-
P
F
K
-
V
------------
V
E
-
K
K
-
T
K
-
P
Y
------------
I
Q
-
V
----
D
----
I
G
GGQTK
T
F
---
A
---
P
E
---
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
---------------
G
E
K
--
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
D
----
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
KLYK
K
-----
K
----
T
G
K
----
D
V
----
R
K
D
-
N
R
A
V
Q
K
L
---
R
R
E
V
E
K
-
A
K
R
A
L
---
S
S
--
Q
H
Q
A
R
I
--
E
I
ESFYEG
E
------
D
----------
F
S
E
------
T
----------
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
-
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
76.65
41%
-79
- C5 -
3LDL
1
GRP78_HUMAN
A:
[8-383]
---------------------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
-
P
F
K
-
V
------------
V
E
-
K
K
-
T
K
-
P
Y
------------
I
Q
-
V
----
D
----
I
G
GG
Q
T
K
T
F
---
A
---
P
E
---
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R------
E
-------
G
E
K
--
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
D
----
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
-----
K
----
T
G
K
----
D
V
----
R
K
D
-
N
R
A
V
Q
K
L
---
R
R
E
V
E
K
-
A
K
R
A
L
---
S
S
--
Q
H
Q
A
R
I
--
E
I
E
SFYEG
E
------
D
----------
F
S
E
------
T
----------
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
-
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
75.88
41%
-79
- C5 -
3LDL
2
GRP78_HUMAN
B:
[8-383]
---------------------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
PS
V
Q
Q
D
I
K
F
L
-
P
F
K
-
V
------------
V
E
-
K
K
-
T
K
-
P
Y
------------
I
Q
-
V
----
D
----
I
G
GGQTK
T
F
---
A
---
P
E
---
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R------
E
-------
G
E
K
--
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
D
----
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
KLYK
K
-----
K
----
T
G
K
----
D
V
----
R
K
D
-
N
R
A
V
Q
K
L
---
R
R
E
V
E
K
-
A
K
R
A
L
---
S
S
--
Q
H
Q
A
R
I
--
E
I
ESFYEG
E
------
D
----------
F
S
E
------
T
----------
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
-
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
75.75
41%
-79
- C5 -
3LDO
1
GRP78_HUMAN
B:
[8-383]
---------------------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
PS
V
Q
Q
D
I
K
F
L
-
P
F
K
-
V
------------
V
E
-
K
K
-
T
K
-
P
Y
------------
I
Q
-
V
----
D
----
I
G
GGQTK
T
F
---
A
---
P
E
---
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R------
E
-------
G
E
K
--
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
D
----
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
KLYK
K
-----
K
----
T
G
K
----
D
V
----
R
K
D
-
N
R
A
V
Q
K
L
---
R
R
E
V
E
K
-
A
K
R
A
L
---
S
S
--
Q
H
Q
A
R
I
--
E
I
ESFYEG
E
------
D
----------
F
S
E
------
T
----------
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
-
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
75.63
39%
-76
- C5 -
3AY9
5
HS71A_HUMAN
A:
[10-386]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
-
P
F
Q
V
I
------------
N
D
-
G
D
-
K
P
K
V
Q
------------
V
S
-
Y
----
K
----
G
E
-----
T
K
---
A
F
Y
-
P
E
---
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
-------
T
-------
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
----
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
----
E
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
L
E
I
--
D
S
LFEG--
I
------
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
75.55
42%
-79
- C5 -
3QFU
3
GRP78_YEAST
A:
[21-394]
---------------------
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
T
D
D
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
T
I
F
D
I
K
R
L
I
G
L
K
Y
N
D
R
S
V
Q
K
D
I
K
H
L
-
P
F
N
-
V
------------
V
N
-
K
D
-
G
K
-
P
A
------------
V
E
V
S
----
V
----
K
G
-----
E
K
K
V
F
T
---
P
E
---
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-------
S
D------
K
E
H
--
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
E
----
N
----
G
V
F
E
V
Q
A
T
S
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
-----
K
----
H
G
I
----
D
V
----
S
D
N
-
N
K
A
L
A
K
L
---
K
R
E
A
E
K
-
A
K
R
A
L
---
S
S
--
Q
M
S
T
R
I
--
E
I
------
D
SFVDG
I
D
----------
L
S
E
------
T
----------
L
T
R
A
K
F
E
E
L
N
L
D
L
F
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
D
G
-
K
K
A
S
K
-
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
75.50
41%
-75
- C5 -
3QFU
3
GRP78_YEAST
A:
[16-393]
----------------
N
Y
G
T
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
T
D
D
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
T
I
F
D
I
K
R
L
I
G
L
K
Y
N
D
R
S
V
Q
K
D
I
K
H
L
-
P
F
N
-
V
------------
V
N
-
K
D
G
K
P
A
V
E
------------
V
S
-
V
KG--
E
----
K
K
-----
V
F
---
T
---
P
E
---
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-------
S
D------
K
E
H
--
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
E
----
N
----
G
V
F
E
V
Q
A
T
S
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
----
K
-----
A
----
F
K
K
----
K
H
GIDV
S
D
N
-
N
K
A
L
A
K
L
---
K
R
E
A
E
K
-
A
K
R
A
L
---
S
S
--
Q
M
S
T
R
I
--
E
I
------
D
------
S
FVDG
I
D
----
L
S
E
------
T
----------
L
T
R
A
K
F
E
E
L
N
L
D
L
F
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
-
D
G
K
K
A
S
K
-
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
75.50
41%
-77
- C5 -
3LDO
1
GRP78_HUMAN
A:
[8-384]
---------------------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
-
P
F
K
-
V
------------
V
E
-
K
K
-
T
K
-
P
Y
------------
I
Q
-
V
----
D
----
I
G
GG
Q
T
K
T
F
---
A
---
P
E
---
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R------
E
-------
G
E
K
--
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
D
----
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
-----
K
----
T
G
K
----
D
V
----
R
K
D
-
N
R
A
V
Q
K
L
---
R
R
E
V
E
K
-
A
K
R
A
L
---
S
S
--
Q
H
Q
A
R
I
--
E
I
E
SFYEG
E
------
D
----------
F
S
E
------
T
----------
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
-
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
75.38
39%
-81
- C5 -
4IO8
1
HS71A_HUMAN
A:
[6-379]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
-
P
F
Q
V
I
------------
N
D
-
G
D
-
K
P
K
V
Q
------------
V
S
-
Y
----
K
----
G
D
-----
T
K
---
A
F
Y
-
P
E
---
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
-------
T
-------
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
----
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
----
E
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
L
E
I
--
D
S
LFEG--
I
------
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
75.22
39%
-74
- C5 -
3ATU
4
HS71A_HUMAN
A:
[10-386]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
-
P
F
Q
V
I
------------
N
D
-
G
D
-
K
P
K
V
Q
------------
V
S
-
Y
----
K
----
G
E
-----
T
K
---
A
F
Y
-
P
E
---
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
-------
T
-------
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
----
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
----
E
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
L
E
I
--
D
S
LFEG--
I
------
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
75.21
39%
-77
- C5 -
2E8A
2
HS71A_HUMAN
A:
[9-385]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
-
P
F
Q
V
I
------------
N
D
-
G
D
-
K
P
K
V
Q
------------
V
S
-
Y
----
K
----
G
E
-----
T
K
---
A
F
Y
-
P
E
---
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
-------
T
-------
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
----
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
----
E
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
L
E
I
--
D
S
LFEG--
I
------
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
75.18
39%
-82
- C5 -
3I33
3
HSP72_HUMAN
A:
[25-402]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
I
F
D
A
K
R
L
I
G
R
K
F
E
D
A
T
V
Q
S
D
M
K
H
W
-
P
F
R
-
V
V
S
E
GG
K
P
K
V
Q
V
E
Y
K
-
G
E
-
T
K
T
F
F
-----------------------------------------
P
E
---
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KGCA---
G
-------
G
E
K
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
----
E
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
G
P
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
V
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
75.18
40%
-82
- C5 -
3GDQ
3
HS71L_HUMAN
A:
[29-406]
-------------------
I
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
N
D
P
-
V
V
Q
A
D
M
K
L
W
P
F
Q
-
V
------------
I
N
-
E
G
-
G
K
P
K
V
------------
L
V
-
S
----
Y
----
K
G
-----
E
N
---
K
A
F
Y
P
E
---
E
I
S
S
M
V
L
T
K
L
K
E
T
A
E
A
F
L
G
H
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-------
G
----------
E
R
H
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
----
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
S
H
F
V
----
E
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
---
S
S
--
S
T
Q
A
N
L
--
E
I
------
D
SLYEG
I
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
C
A
D
L
F
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
M
D
K
A
K
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
R
L
L
Q
D
Y
F
-
N
-
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
75.07
39%
-82
- C5 -
3A8Y
1
HS71A_HUMAN
A:
[10-387]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
-
P
F
Q
V
I
------------
N
D
-
G
D
-
K
P
K
V
Q
------------
V
S
-
Y
----
K
----
G
E
-----
T
K
---
A
F
Y
-
P
E
---
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
-------
T
-------
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
----
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
----
E
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
L
E
I
--
D
S
LFEG--
I
------
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
74.91
39%
-76
- C5 -
3ATV
3
HS71A_HUMAN
A:
[10-386]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
-
P
F
Q
V
I
------------
N
D
-
G
D
-
K
P
K
V
Q
------------
V
S
-
Y
----
K
----
G
E
-----
T
K
---
A
F
Y
-
P
E
---
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
-------
T
-------
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
----
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
----
E
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
L
E
I
--
D
S
LFEG--
I
------
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
74.80
41%
-79
- C5 -
3LDP
1
GRP78_HUMAN
B:
[8-383]
---------------------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
PS
V
Q
Q
D
I
K
F
L
-
P
F
K
-
V
------------
V
E
-
K
K
-
T
K
-
P
Y
------------
I
Q
-
V
----
D
----
I
G
GGQTK
T
F
---
A
---
P
E
---
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R------
E
-------
G
E
K
--
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
D
----
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
KLYK
K
-----
K
----
T
G
K
----
D
V
----
R
K
D
-
N
R
A
V
Q
K
L
---
R
R
E
V
E
K
-
A
K
R
A
L
---
S
S
--
Q
H
Q
A
R
I
--
E
I
ESFYEG
E
------
D
----------
F
S
E
------
T
----------
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
-
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
74.72
40%
-76
- C5 -
1NGI
2
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
74.66
40%
-73
- C5 -
4H5V
9
HSP7C_HUMAN
A:
[5-383]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
74.63
39%
-79
- C5 -
4J8F
14
F10A1_RAT (first)
A:
[13-389]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
-
P
F
Q
V
I
------------
N
D
-
G
D
-
K
P
K
V
Q
------------
V
S
-
Y
----
K
----
G
E
-----
T
K
---
A
F
Y
-
P
E
---
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
-------
T
-------
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
----
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
----
E
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
L
E
I
--
D
S
LFEG--
I
------
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
74.59
39%
-75
- C5 -
1QQN
6
HSP7C_BOVIN
A:
[3-378]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
A
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
A
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
A
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
AV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
S
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
A
H
----
A
K
D
-
I
S
E
N
K
R
A
V
R
R
L
A
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
74.56
40%
-77
- C5 -
1HPM
6
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
74.55
40%
-76
- C5 -
2QWL
4
HSP7C_BOVIN
B:
[6-384]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
MVVNDAGRPKVQ
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
FY-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
VRR
L
R
T
A
C
E
-
R
A
K
R
T
LSS
S
T
--
Q
A
S
I
E
I
DS
L
Y
------
E
GI----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
74.51
41%
-76
- C5 -
3FE1
2
HSP76_HUMAN
C:
[25-402]
-------------------
L
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
T
V
F
D
A
K
R
L
I
G
R
K
F
A
D
--
T
T
V
Q
S
D
M
K
-
H
W
P
-
F
------------
R
V
V
S
E
-
G
G
K
P
K
------------
V
R
-
V
----
C
Y
RG
E
D
K
-----
T
F
---
Y
---
P
E
---
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
RG-----
A
-------
G
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
D
----
A
----
G
V
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
----
E
-----
E
----
F
R
R
----
K
H
----
G
K
D
L
S
G
N
K
R
A
L
R
R
-
L
R
T
A
C
E
R
A
K
R
T
L
---
S
S
--
S
T
Q
A
T
L
--
E
I
------
D
SLFEG
V
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
74.50
40%
-81
- C5 -
3FZH
1
HSP7C_HUMAN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
74.50
40%
-79
- C5 -
3M3Z
1
HSP7C_HUMAN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
74.49
39%
-71
- C5 -
2QWO
7
HSP7C_BOVIN
A:
[6-390]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
SE
N
V
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
74.47
40%
-77
- C5 -
1BA1
4
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
K
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
74.41
41%
-75
- C5 -
3FE1
4
HSP76_HUMAN
B:
[25-403]
-------------------
L
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
T
V
F
D
A
K
R
L
I
G
R
K
F
A
D
--
T
T
V
Q
S
D
M
K
-
H
W
P
-
F
------------
R
V
V
S
E
-
G
G
K
P
K
------------
V
R
-
V
----
C
Y
RG
E
D
K
-----
T
F
---
Y
---
P
E
---
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
R
G
-----
A
-------
G
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
D
----
A
----
G
V
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
----
E
-----
E
----
F
R
R
----
K
H
----
G
K
D
L
S
G
N
K
R
A
L
R
R
-
L
R
T
A
C
E
R
A
K
R
T
L
---
S
S
--
S
T
Q
A
T
L
--
E
I
------
D
SLFEG
V
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
74.39
40%
-73
- C5 -
4H5N
9
HSP7C_HUMAN
A:
[5-383]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
DS
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
74.37
40%
-75
- C5 -
4H5R
10
HSP7C_HUMAN
A:
[5-383]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
74.34
40%
-75
- C5 -
2QWM
5
HSP7C_BOVIN
B:
[6-384]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
MVVNDAGRPKVQ
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
FY-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
VRR
L
R
T
A
C
E
-
R
A
K
R
T
LSS
S
T
--
Q
A
S
I
E
I
DS
L
Y
------
E
GI----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
74.33
40%
-81
- C5 -
3FZM
1
HSP7C_HUMAN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
74.32
40%
-75
- C5 -
4H5R
8
HSP7C_HUMAN
B:
[5-383]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
MVVNDAGRPKVQ
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
FY-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
VRR
L
R
T
A
C
E
-
R
A
K
R
T
LSS
S
T
--
Q
A
S
I
E
I
DS
L
Y
------
E
GI----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
74.32
40%
-75
- C5 -
4H5W
5
HSP7C_HUMAN
A:
[5-383]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
74.30
39%
-76
- C5 -
2QWN
5
HSP7C_BOVIN
A:
[6-385]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
S--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
74.29
41%
-78
- C5 -
3FE1
2
HSP76_HUMAN
A:
[25-403]
-------------------
L
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
T
V
F
D
A
K
R
L
I
G
R
K
F
A
D
--
T
T
V
Q
S
D
M
K
-
H
W
P
-
F
------------
R
V
V
S
E
-
G
G
K
P
K
------------
V
R
-
V
----
C
Y
RG
E
D
K
-----
T
F
---
Y
---
P
E
---
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
R
G
-----
A
-------
G
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
D
----
A
----
G
V
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
----
E
-----
E
----
F
R
R
----
K
H
----
G
K
D
L
S
G
N
K
R
A
L
R
R
-
L
R
T
A
C
E
R
A
K
R
T
L
---
S
S
--
S
T
Q
A
T
L
--
E
I
------
D
SLFEG
V
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
74.24
39%
-75
- C5 -
1QQO
4
HSP7C_BOVIN
A:
[3-378]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
A
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
S
P
T
A
A
A
I
A
Y
G
L
D
K
AV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
74.23
39%
-74
- C5 -
1NGF
1
HSP7C_BOVIN
A:
[6-384]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
N
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
74.18
40%
-73
- C5 -
2QWL
4
HSP7C_BOVIN
A:
[6-384]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
74.11
40%
-81
* C5 *
3I33
3
HSP72_HUMAN
A:
[23-401]
------------------
M
P
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
I
F
D
A
K
R
L
I
G
R
K
F
E
D
A
T
V
Q
S
D
M
K
H
W
-
P
F
R
-
V
------------
V
S
-
E
--
G
G
K
P
K
------------
V
Q
-
V
E
Y
KG
E
----
T
K
-----
T
F
---
F
---
P
E
---
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-------
K
GCAG---
G
E
K
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
----
E
-----
E
----
F
K
R
----
K
H
KKDI
G
P
N
-
K
R
A
V
R
R
L
---
R
T
A
C
E
R
-
A
K
R
T
L
---
S
S
--
S
T
Q
A
S
I
--
E
I
------
D
------
S
LYEG
V
D
----
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
G
K
E
L
N
K
-
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
74.09
39%
-72
- C5 -
1ATR
3
HSP7C_BOVIN
A:
[6-384]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
V
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
74.05
39%
-77
- C5 -
1KAY
6
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
A
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
74.05
40%
-81
- C5 -
3FZL
2
HSP7C_HUMAN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
74.03
39%
-79
- C5 -
1BA0
5
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
K
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
73.97
39%
-77
- C5 -
3JXU
2
HS71A_HUMAN
A:
[28-403]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
-
P
F
Q
V
I
------------
N
D
-
G
D
-
K
P
K
V
Q
------------
V
S
-
Y
----
K
----
G
E
-----
T
K
---
A
F
Y
-
P
E
---
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
-------
T
-------
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
----
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
----
E
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
L
E
I
--
D
S
LFEG--
I
------
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
73.89
39%
-75
- C5 -
3A8Y
1
HS71A_HUMAN
B:
[10-385]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
-
P
F
Q
V
I
------------
N
D
-
G
D
-
K
P
K
V
Q
------------
V
S
-
Y
----
K
----
G
E
-----
T
K
---
A
F
Y
-
P
E
---
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
-------
T
-------
G
--
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
----
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
----
E
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
L
E
I
--
D
S
LFEG--
I
------
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
73.85
40%
-80
- C5 -
3FZK
3
HSP7C_HUMAN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
73.83
40%
-84
- C5 -
3LDQ
1
HSP7C_HUMAN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
V
-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
73.82
39%
-76
- C5 -
1NGB
2
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
Q
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
73.82
40%
-74
- C5 -
2QWM
5
HSP7C_BOVIN
A:
[6-384]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
73.69
39%
-76
- C5 -
1NGG
1
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
S
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
73.64
39%
-76
- C5 -
2QWQ
5
HSP7C_BOVIN
A:
[6-386]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
V
-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
SE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
73.60
40%
-71
- C5 -
1NGJ
2
HSP7C_BOVIN
A:
[6-384]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
73.60
40%
-74
- C5 -
3HSC
5
HSP7C_BOVIN
A:
[6-384]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
73.56
40%
-80
- C5 -
3FZF
1
HSP7C_HUMAN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
73.50
39%
-76
- C5 -
1KAZ
6
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
E
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
73.48
39%
-77
- C5 -
2BUP
6
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
G
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
73.48
39%
-75
- C5 -
1NGE
1
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
S
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
73.38
39%
-77
- C5 -
1NGA
2
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
S
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
73.37
39%
-76
- C5 -
1NGD
3
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
N
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
73.36
39%
-75
- C5 -
1KAX
6
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
M
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
73.35
39%
-75
- C5 -
1NGH
1
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
N
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
73.31
39%
-75
- C5 -
1BUP
6
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
S
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
73.28
40%
-73
- C5 -
4H5W
4
HSP7C_HUMAN
B:
[5-383]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
MVVNDAGRPKVQ
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
FY-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
VRR
L
R
T
A
C
E
-
R
A
K
R
T
LSS
S
T
--
Q
A
S
I
E
I
DS
L
Y
------
E
GI----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
73.14
40%
-76
- C5 -
4H5T
3
HSP7C_HUMAN
A:
[5-383]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
73.03
39%
-77
- C5 -
2QWR
4
HSP7C_BOVIN
A:
[6-386]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
V
-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
SE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
72.96
39%
-73
- C5 -
1NGC
2
HSP7C_BOVIN
A:
[6-381]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
S
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
72.91
39%
-76
- C5 -
1ATS
2
HSP7C_BOVIN
A:
[6-383]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
E
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
72.75
40%
-78
- C5 -
1HX1
1
HSP7C_BOVIN
A:
[25-400]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
72.45
39%
-76
- C5 -
2QWP
7
HSP7C_BOVIN
A:
[6-389]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
-
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
--
A
V
V
Q
S
D
M
-------------------------
K
H
W
P
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
-
Y
----
K
----
G
E
-----
T
K
---
S
F
Y
-
P
E
---
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KV-----
G
-------
A
E
R
--
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
----
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
----
A
-----
E
----
F
K
R
----
K
H
----
K
K
D
-
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
-
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
------
E
G
I
----
D
----------
F
Y
T
------
S
----------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
SE
N
V
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------