@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3883: (2016-02-21 )
MSQPVAFVTGCSSGIGRALADAFQRAGYRVWASARKEDDVRALAEAGFQAVQLDVNDAAALARLAEELGVEAAGLDVLVNNAGYGAMGPLLDGGVEAMRRQFETNVFAVVGVTRALFPLLRRKSGLVVNVGSVSGVLVTPFAGAYCASKAAVHALSDALRLELAPFGVEVLEVQPGAIASNFGASASREMDSVVDERSPWWPLRRQIQARAAASQDNPTSAEDFARQLLAAVQRRPRPPLVRIGNGSRALPALARWLPRGLLERLLKKRFGLDTRL
Atome Classification :
(24 SA)
.........10........20----.........30......-------..40...--.....50........60........70........80........90........100.......110......-.120-.......130.......140.......150.......160.......170.......180.......190.......200.......210...------....220.......230.......240.......250.......260.......270....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQP
V
A
F
V
T
G
C
SS
G
I
G
R
A
L
A
-----
D
A
F
Q
RAG
Y
R
V
W
A
SARKE-------
D
D
V
R
A
L
A
--
E
AG
F
Q
A
V
Q
L
DVN
D
A
A
A
L
A
R
L
A
E
E
LGVEAAG
L
D
V
L
VNNAGYGAM
G
P
L
L
D
G
G
V
E
A
M
R
R
Q
FETNV
F
A
V
V
G
V
T
R
A
L
F
P
-
L
L
R
R-KS
G
L
V
V
N
VGSV
S
G
V
L
VTPFAG
A
Y
C
A
S
K
A
A
V
H
A
L
S
D
A
L
R
L
ELAPFG
V
E
V
L
E
VQPGAIASNFGAS
A
S
R
E
M
D
S
V
VDERSP
W
W
P
L
R
R
Q
I
Q
A
R
AAASQ------DNPT
S
A
E
D
F
A
R
Q
L
L
A
A
V
QRRPRP
P
L
V
R
IGNGS
R
A
L
P
A
L
A
R
W
L
P
R
G
L
L
E
R
L
L
K
K
RFGLDTRL
1
PsiBlast_PDB
85.34
35%
-94
- C1 -
1IOL
1
DHB1_HUMAN
A:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQ
G
R
L
W
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
E
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
18
PsiBlast_PDB
83.84
34%
-92
- C1 -
3HB5
2
DHB1_HUMAN
X:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
VRLAS
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQGRLW
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
VFREAA
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
7
PsiBlast_PDB
83.47
34%
-94
- C1 -
1EQU
2
DHB1_HUMAN
A:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQ
G
R
L
W
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
AA
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
17
PsiBlast_PDB
83.32
34%
-95
- C1 -
3HB4
1
DHB1_HUMAN
X:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
VRLAS
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQGRLW
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
VFREAA
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
4
PsiBlast_PDB
83.30
34%
-92
- C1 -
1FDT
3
DHB1_HUMAN
A:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQ
G
R
L
W
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
24
PsiBlast_CBE
83.15
34%
-93
- C1 -
1FDV
3
DHB1_HUMAN
C:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
VRLAS
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQGRLW
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
VFREAA
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
30
PsiBlast_CBE
82.97
34%
-98
- C1 -
1FDU
3
DHB1_HUMAN
A:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQ
G
R
L
W
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
----
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
26
PsiBlast_CBE
82.96
34%
-93
- C1 -
1FDV
3
DHB1_HUMAN
A:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQ
G
R
L
W
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
28
PsiBlast_CBE
82.82
34%
-93
- C1 -
1FDU
3
DHB1_HUMAN
C:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQ
G
R
L
W
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
3
PsiBlast_PDB
82.63
34%
-95
- C1 -
1FDS
1
DHB1_HUMAN
A:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQ
G
R
L
W
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
-----
V
L
G
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
AA
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
2
PsiBlast_PDB
82.46
34%
-92
- C1 -
1A27
2
DHB1_HUMAN
A:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQ
G
R
L
W
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
22
PsiBlast_CBE
82.35
34%
-96
- C1 -
1EQU
1
DHB1_HUMAN
B:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
VRLAS
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQGRLW
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
VFREAA
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
29
PsiBlast_CBE
82.13
34%
-95
- C1 -
1FDU
3
DHB1_HUMAN
B:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQ
G
R
L
W
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
-----
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
10
PsiBlast_PDB
81.72
34%
-91
- C1 -
1I5R
3
DHB1_HUMAN
A:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQ
G
R
L
W
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
AA
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
15
PsiBlast_PDB
81.67
34%
-92
- C1 -
1BHS
-
DHB1_HUMAN
A:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQ
G
R
L
W
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
21
PsiBlast_CBE
81.21
34%
-98
- C1 -
3KM0
2
DHB1_HUMAN
B:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQ
G
R
L
W
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
------------
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
8
PsiBlast_PDB
81.02
34%
-91
- C1 -
1DHT
1
DHB1_HUMAN
A:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQ
G
R
L
W
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
9
PsiBlast_PDB
80.74
34%
-94
- C1 -
3DHE
1
DHB1_HUMAN
A:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQ
G
R
L
W
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
12
PsiBlast_PDB
79.67
34%
-95
- C1 -
1QYV
1
DHB1_HUMAN
A:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQ
G
R
L
W
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
--------
S
P
E
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
27
PsiBlast_CBE
79.06
34%
-95
- C1 -
1FDU
3
DHB1_HUMAN
D:
[4-263]
----
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
VRLAS
D
P
S
Q
--
S
F
K
V
Y
A
T
L
R
D
L
KTQGRLW
E
A
A
R
A
L
A
CP
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
--
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
-
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
----
E
V
L
D
-
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
VFREAA
Q
N
P
---
E
E
V
A
E
V
F
L
T
A
L
-
R
A
P
K
P
T
L
-
R
Y
F
T
T
E
R
F
L
P
L
L
-----------------------
56
PsiBlast_CBE
61.50
35%
-96
- C1 -
2D1Y
1
?
D:
[10-192]
------
L
V
T
G
G
A
R
G
I
G
R
A
I
A
-----
Q
A
F
A
R
E
G
A
L
V
A
L
C
D
L
R
P
-------
E
G
K
E
V
A
E
--
A
I
G
G
A
F
F
Q
V
D
L
E
D
E
R
E
R
V
R
F
V
E
E
A
A
Y
A
L
G
R
V
D
V
L
V
N
N
A
A
I
A
A
P
G
S
A
L
T
V
R
L
P
E
W
R
R
V
L
E
V
N
L
T
A
P
M
H
L
S
A
L
A
A
R
-
E
M
R
K
V
G
G
G
A
I
V
N
V
A
S
V
Q
G
L
F
A
E
Q
E
N
A
A
Y
N
A
S
K
G
G
L
V
N
L
T
R
S
L
A
L
D
L
A
P
L
R
I
R
V
N
A
V
A
P
G
A
I
A
T
E
-----------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
61.38
35%
-98
- C1 -
2D1Y
1
?
C:
[10-185]
------
L
V
T
G
G
A
R
G
I
G
R
A
I
A
-----
Q
A
F
A
R
E
G
A
L
V
A
L
C
D
L
R
P
-------
E
G
K
E
V
A
E
--
A
I
G
G
A
F
F
Q
V
D
L
E
D
E
R
E
R
V
R
F
V
E
E
A
A
Y
A
L
G
R
V
D
V
L
V
N
N
A
A
I
A
A
P
G
S
A
L
T
V
R
L
P
E
W
R
R
V
L
E
V
N
L
T
A
P
M
H
L
S
A
L
A
A
R
-
E
M
R
K
V
G
G
G
A
I
V
N
V
A
S
V
Q
G
L
F
A
E
Q
E
N
A
A
Y
N
A
S
K
G
G
L
V
N
L
T
R
S
L
A
L
D
L
A
P
L
R
I
R
V
N
A
V
A
P
G
A
I
A
T
E
-----------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
60.80
35%
-95
- C1 -
2D1Y
1
?
A:
[10-193]
------
L
V
T
G
G
A
R
G
I
G
R
A
I
A
-----
Q
A
F
A
R
E
G
A
L
V
A
L
C
D
L
R
P
-------
E
G
K
E
V
A
E
--
A
I
G
G
A
F
F
Q
V
D
L
E
D
E
R
E
R
V
R
F
V
E
E
A
A
Y
A
L
G
R
V
D
V
L
V
N
N
A
A
I
A
A
P
G
S
A
L
T
V
R
L
P
E
W
R
R
V
L
E
V
N
L
T
A
P
M
H
L
S
A
L
A
A
R
-
E
M
R
K
V
G
G
G
A
I
V
N
V
A
S
V
Q
G
L
F
A
E
Q
E
N
A
A
Y
N
A
S
K
G
G
L
V
N
L
T
R
S
L
A
L
D
L
A
P
L
R
I
R
V
N
A
V
A
P
G
A
I
A
T
E
-----------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
59.22
35%
-95
- C1 -
2D1Y
1
?
B:
[10-192]
------
L
V
T
G
G
A
R
G
I
G
R
A
I
A
-----
Q
A
F
A
R
E
G
A
L
V
A
L
C
D
L
R
P
-------
E
G
K
E
V
A
E
--
A
I
G
G
A
F
F
Q
V
D
L
E
D
E
R
E
R
V
R
F
V
E
E
A
A
Y
A
L
G
R
V
D
V
L
V
N
N
A
A
I
A
A
P
G
S
A
L
T
V
R
L
P
E
W
R
R
V
L
E
V
N
L
T
A
P
M
H
L
S
A
L
A
A
R
-
E
M
R
K
V
G
G
G
A
I
V
N
V
A
S
V
Q
G
L
F
A
E
Q
E
N
A
A
Y
N
A
S
K
G
G
L
V
N
L
T
R
S
L
A
L
D
L
A
P
L
R
I
R
V
N
A
V
A
P
G
A
I
A
T
E
-----------------------------------------------------------------------------------------------------