@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3950: (2016-02-22 )
MTFASLGLLDPLLKALEGLGHGTPTPIQAQAIPPALKGRDLLAAAQTGTGKTAGFALPLLQRLTLEGPQVAANSVRALVLVPTRELAEQVHASVRDYGQHLPLRTAVAYGGVSINPQMMKLRKGVDILVATPGRLLDLYRQNAVKFAQLQALVLDEADRMLDLGFARELDELFAALPRKRQTLLFSATFSDAIRTLARELLRDPLSIEVSPRNTAAKSVRQWLVPVDKKRKAELFCHLLQANRWRQALVFAKTRKSVEELVGLLQRQGIAADSIHGDKPQPARLRALQRFKAGEVDLLVATDVAARGLDIEEMPLVVNFDLPIVAEDYVHRIGRTGRAGASGQAVSLVCADEVELLAAIETLIGQTLQRREEPDFEPEHRVPQTAPGGVVLKKPKKPKKPKAAESVGKPGKIHLGSWFDSSAPTVKAVRKAPGFGAGAAGKPKKRPSGK
Atome Classification :
(66 SA)
.........10.-........20........30.....--.--.--.40........50........60..--......-------------70....---.-------------...80........90....---....100---.-.---.....-.-110.......120-..-..----.--...130.....-..140--....---...-150.......160.--.-.-.....170.----.--..----.-------..--180-----.........190.......200-........210----..--.....220......-.-.-230----.....---...240-.-...----....250.......260...---..---..270.......280.......290.......300.......310.......320.------...------...330.......340.....--------.-.-350.-.......360.......370.......380.......390.......400.......410.......420.......430.......440.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
F
A
S
L
G
L
L
D
-
P
-
L
L
K
A
L
E
G
LGHGTPTPIQAQAIPPAL--K--G--R
D
L
L
A
A
AQTGTGKTA
G
F
A
L
P
L
L
Q
R
L--TLEGPQ-------------VAANS
V
---
R
-------------
A
L
V
L
V
P
T
R
E
L
A
E
Q
V
H
A
S
V
R
---
D
Y
G
QHL----P-
L
---
R
T
A
V
A
-Y-GGVSI
N
P
Q
M
M
K
-
L
-RK-G
V
----
D
--
I
L
VAT
P
G
R
L
L
D
-
L
Y
R
Q
N
--
A
V
K
F
---
A
Q
L
-
Q
A
L
V
L
DE
A
D
R
M
L
-
D
--
L
-
G
-
F
A
R
E
L
D
E
L
F
----
A
--AL----P-------RK--R-------
Q
T
L
L
F
S
A
T
F
S
D
A
I
R
T
L
A
R
E
L
L--RDP
L
S
I
E
VSPR----
N
T
--
A
A
K
S
V
R
Q
-
W
LVPVD-K-
K
-
R
-
K
----
A
E
L
F
C
---
H
L
L
Q
-
A
-
N
-
R
W
R
----
Q
A
L
V
F
A
K
T
R
K
S
V
E
E
L
V
G
L
L
Q
---RQ---GIAADSIHGDKPQ
P
A
R
L
R
A
L
Q
R
FKAGE
V
D
L
L
V
AT
D
V
AARGLDIEEM
P
L
V
V
NFDLPI------
V
A
E
------
D
Y
V
H
RIGRTGRAGASG
Q
A
V
S
L
--------
V
-
C
-
A
D
-
E
-
V
E
L
L
A
A
I
E
T
L
I
G
Q
T
L
Q
R
REEPDFEPEHRVPQTAPG
G
V
V
L
KKPKKPKKP
K
A
A
E
SVGKPG
K
I
H
L
G
S
WFDSSA
P
T
V
K
A
V
R
KAPGFGAGAAGKPKKRPSGK
1
PsiBlast_PDB
87.94
41%
-105
- C4 -
4D25
4
?
A:
[61-431]
-------
V
L
D
-
N
-
V
L
K
A
----
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
--
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
---
L
Q
D
P
K
D
L
-----------
I
S
E
N
G
C
A
Q
P
Q
-------------
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
---
K
F
S
Y
G
S
----
V
-
L
---
K
V
A
V
A
-
Y
-
G
G
T
A
V
R
H
Q
G
D
N
-
I
-
A
R
-
G
C
----
H
--
I
L
V
A
T
P
G
R
L
H
D
-
F
V
E
R
N
--
R
V
S
F
---
G
S
V
-
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
--
M
-
G
-
F
M
P
S
I
E
K
M
M
L
HPT
M
--
V
E
----
T
-------
T
K
--
R
-------
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
--
N
N
Y
L
F
V
A
V
G
I
V
----
G
G
--
A
S
T
D
V
E
Q
-
I
F
I
E
V
T
-
K
-
Y
-
E
-
K
----
R
N
S
L
K
---
Q
L
I
E
-
E
-
N
-
D
G
K
----
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
---
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
D
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
--------
Y
-
D
-
S
D
Q
D
-
L
A
L
V
A
D
L
S
K
I
L
R
Q
A
D
Q
--
S
V
P
D
F
--------------------------------------------------------------------------
30
PsiBlast_CBE
87.80
43%
-115
- C4 -
4KBG
4
?
B:
[1-363]
M
E
F
K
D
F
P
L
K
P
-
E
-
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
--
P
S
Q
-------------
E
R
G
R
K
P
---
R
-------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
----------
K
V
V
A
V
-
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
-
L
R
-
G
A
----
D
--
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
--
V
L
D
L
---
S
R
V
-
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
----
S
--
A
T
----
P
-------
P
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
--
K
N
P
V
L
I
N
V
I
K
D
----
E
P
--
V
--
T
Y
E
E
-
E
A
V
P
A
P
-
V
-
R
-
G
-
R
----
L
E
V
L
S
---
D
L
L
Y
-
V
-
A
-
S
P
D
----
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
---
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
E
------
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
--------
Y
-
G
-
P
R
-
E
-
R
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
R
--------------------------------------------------------------------------------
31
PsiBlast_CBE
87.78
43%
-122
- C4 -
4KBF
1
?
B:
[1-363]
M
E
F
K
D
F
P
L
K
P
-
E
-
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
--
P
S
Q
-------------
E
R
G
R
K
P
---
R
-------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
----------
K
V
V
A
V
-
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
-
L
R
-
G
A
----
D
--
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
--
V
L
D
L
---
S
R
V
-
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
----
S
--
A
T
----
P
-------
P
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
--
K
N
P
V
L
I
N
V
I
K
D
----
E
P
--
V
--
T
Y
E
E
-
E
A
V
P
A
P
-
V
-
R
-
G
-
R
----
L
E
V
L
S
---
D
L
L
Y
-
V
-
A
-
S
P
D
----
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
---
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
E
------
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
--------
Y
-
G
-
P
R
-
E
-
R
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
R
--------------------------------------------------------------------------------
2
PsiBlast_PDB
87.46
41%
-103
- C4 -
4D26
4
?
A:
[61-431]
-------
V
L
D
-
N
-
V
L
K
A
----
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
--
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
---
L
Q
D
P
K
D
L
-----------
I
S
E
N
G
C
A
Q
P
Q
-------------
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
---
K
F
S
Y
G
S
----
V
-
L
---
K
V
A
V
A
-
Y
-
G
G
T
A
V
R
H
Q
G
D
N
-
I
-
A
R
-
G
C
----
H
--
I
L
V
A
T
P
G
R
L
H
D
-
F
V
E
R
N
--
R
V
S
F
---
G
S
V
-
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
--
M
-
G
-
F
M
P
S
I
E
K
M
M
L
HPT
M
--
V
E
----
T
-------
T
K
--
R
-------
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
--
N
N
Y
L
F
V
A
V
G
I
V
----
G
G
--
A
S
T
D
V
E
Q
-
I
F
I
E
V
T
-
K
-
Y
-
E
-
K
----
R
N
S
L
K
---
Q
L
I
E
-
E
-
N
-
D
G
K
----
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
---
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
D
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
--------
Y
-
D
-
S
D
Q
D
-
L
A
L
V
A
D
L
S
K
I
L
R
Q
A
D
Q
--
S
V
P
D
F
--------------------------------------------------------------------------
121
HHSearch
85.94
39%
-123
- C4 -
2I4I
1
DDX3X_HUMAN
A:
[16-396]
-
S
F
S
D
V
E
M
G
E
-
I
-
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
--
Y
S
D
G
P
G
E
A
L
R
A
M
K
E
NGRYG
R
R
K
Q
Y
P
---
I
-------------
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
---
K
F
S
Y
R
S
----
R
-
V
---
R
P
C
V
V
-
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
-
L
-
E
R
-
G
C
----
H
--
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
--
K
I
G
L
---
D
F
C
-
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
I
R
R
I
V
----
E
--
Q
D
TMPP
K
-------
G
V
--
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
--
D
E
Y
I
F
L
A
V
G
----------
T
S
E
N
I
T
Q
-
K
V
V
W
V
E
-
E
-
S
-
D
-
K
----
R
S
F
L
L
---
D
L
L
N
-
A
T
G
-
K
D
S
----
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
---
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
--------
F
-
N
-
E
R
-
N
-
I
N
I
T
K
D
L
L
D
L
L
V
-------------------------------------------------------------------------------------
15
PsiBlast_PDB
85.58
43%
-108
- C4 -
4KBF
3
?
A:
[1-363]
M
E
F
K
D
F
P
L
K
P
-
E
-
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
--
P
S
Q
-------------
E
R
G
R
K
P
---
R
-------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
----------
K
V
V
A
V
-
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
-
L
R
-
G
A
----
D
--
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
--
V
L
D
L
---
S
R
V
-
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
----
S
--
A
T
----
P
-------
P
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
--
K
N
P
V
L
I
N
V
I
K
D
----
E
P
--
V
--
T
Y
E
E
-
E
A
V
P
A
P
-
V
-
R
-
G
-
R
----
L
E
V
L
S
---
D
L
L
Y
-
V
-
A
-
S
P
D
----
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
---
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
E
------
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
--------
Y
-
G
-
P
R
-
E
-
R
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
R
--------------------------------------------------------------------------------
114
HHSearch
84.54
37%
-108
- C4 -
2DB3
3
VASA1_DROME
A:
[57-420]
-
H
F
T
S
A
D
L
R
D
-
I
-
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
--
L
E
D
P
H
E
-------------
L
E
L
G
R
P
---
Q
-------------
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
---
K
F
A
F
E
S
----
Y
-
L
---
K
I
G
I
V
-
Y
-
G
G
T
S
F
R
H
Q
N
E
C
-
I
-
T
R
-
G
C
----
H
--
V
V
I
A
T
P
G
R
L
L
D
-
F
V
D
R
T
--
F
I
T
F
---
E
D
T
-
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
S
E
D
M
R
R
I
M
----
T
--
H
V
----
T
MR-----
P
E
--
H
-------
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
--
K
N
Y
V
F
V
A
I
G
I
V
----
G
G
--
A
C
S
D
V
K
Q
-
T
I
Y
E
V
N
-
K
-
Y
-
A
-
K
----
R
S
K
L
I
---
E
I
L
S
-
E
---
Q
A
D
----
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
---
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
--------
F
-
D
-
P
E
K
D
-
R
A
I
A
A
D
L
V
K
I
L
--------------------------------------------------------------------------------------
23
PsiBlast_CBE
84.31
36%
-105
- C4 -
2DB3
3
VASA1_DROME
B:
[58-430]
--
F
T
S
A
D
L
R
D
-
I
-
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
--
L
E
D
P
H
E
-------------
L
E
L
G
R
P
---
Q
-------------
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
---
K
F
A
F
E
S
----
Y
-
L
---
K
I
G
I
V
-
Y
-
G
G
T
S
F
R
H
Q
N
E
C
-
I
-
T
R
-
G
C
----
H
--
V
V
I
A
T
P
G
R
L
L
D
-
F
V
D
R
T
--
F
I
T
F
---
E
D
T
-
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
S
E
D
M
R
R
I
M
----
T
--
H
V
----
T
-------
M
R
PE
H
-------
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
--
K
N
Y
V
F
V
A
I
G
I
V
----
G
G
--
A
C
S
D
V
K
Q
-
T
I
Y
E
V
N
-
K
-
Y
-
A
-
K
----
R
S
K
L
I
---
E
I
L
--
S
-
E
-
Q
A
D
----
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
---
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
FDPEKDRA
I
-
A
-
A
D
-
L
-
V
K
I
L
E
G
----
S
G
Q
T
V
-----
P
D
F
--------------------------------------------------------------------------
54
PsiBlast_CBE
84.27
31%
-98
- C4 -
3SQX
3
MS116_YEAST
A:
[26-426]
------
G
V
L
D
K
E
-
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
---
I
N
T
K
F
-------------
D
S
Q
Y
M
V
---
K
-------------
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
----
K
-
K
---
Y
A
C
V
S
L
V
-
G
G
T
D
F
R
A
A
M
N
K
-
M
-
N
K
L
R
P
----
N
--
I
V
I
A
T
P
G
R
L
I
D
-
V
L
E
K
Y
--
S
N
K
F
---
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
L
E
T
I
S
----
G
--
I
L
----
N
-------
E
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
NK
K
E
C
L
F
L
D
T
V
D
K
----
N
E
PE
A
H
E
R
I
D
Q
-
S
V
V
-
I
S
-
E
-
K
-
F
-
A
----
N
S
I
F
A
A
V
E
H
I
K
K
-
Q
-
I
-
K
E
R
D
SN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
---
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
--------
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
--
Y
E
P
S
E
E
I
--------------------------------------------------------------------
4
PsiBlast_PDB
84.03
36%
-104
- C4 -
2DB3
3
VASA1_DROME
A:
[58-430]
--
F
T
S
A
D
L
R
D
-
I
-
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
--
L
E
D
P
H
E
-------------
L
E
L
G
R
P
---
Q
-------------
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
---
K
F
A
F
E
S
----
Y
-
L
---
K
I
G
I
V
-
Y
-
G
G
T
S
F
R
H
Q
N
E
C
-
I
-
T
R
-
G
C
----
H
--
V
V
I
A
T
P
G
R
L
L
D
-
F
V
D
R
T
--
F
I
T
F
---
E
D
T
-
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
S
E
D
M
R
R
I
M
----
T
--
H
V
----
T
-------
M
R
P
E
H
-------
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
--
K
N
Y
V
F
V
A
I
G
I
V
----
G
G
--
A
C
S
D
V
K
Q
-
T
I
Y
E
V
N
-
K
-
Y
-
A
-
K
----
R
S
K
L
I
---
E
I
L
--
S
-
E
-
Q
A
D
----
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
---
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
PEKDRA
I
-
A
-
A
D
-
L
-
V
K
I
L
E
G
----
S
G
Q
T
V
-----
P
D
F
--------------------------------------------------------------------------
21
PsiBlast_CBE
83.99
36%
-104
- C4 -
2DB3
3
VASA1_DROME
D:
[58-430]
--
F
T
S
A
D
L
R
D
-
I
-
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
--
L
E
D
P
H
E
-------------
L
E
L
G
R
P
---
Q
-------------
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
---
K
F
A
F
E
S
----
Y
-
L
---
K
I
G
I
V
-
Y
-
G
G
T
S
F
R
H
Q
N
E
C
-
I
-
T
R
-
G
C
----
H
--
V
V
I
A
T
P
G
R
L
L
D
-
F
V
D
R
T
--
F
I
T
F
---
E
D
T
-
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
S
E
D
M
R
R
I
M
----
T
--
H
V
----
T
-------
M
R
PE
H
-------
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
--
K
N
Y
V
F
V
A
I
G
I
V
----
G
G
--
A
C
S
D
V
K
Q
-
T
I
Y
E
V
N
-
K
-
Y
-
A
-
K
----
R
S
K
L
I
---
E
I
L
--
S
-
E
-
Q
A
D
----
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
---
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
FDPEKDRA
I
-
A
-
A
D
-
L
-
V
K
I
L
E
G
----
S
G
Q
T
V
-----
P
D
F
--------------------------------------------------------------------------
49
PsiBlast_CBE
83.98
31%
-101
- C4 -
3SQW
3
MS116_YEAST
A:
[26-426]
------
G
V
L
D
K
E
-
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
---
I
N
T
K
F
-------------
D
S
Q
Y
M
V
---
K
-------------
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
----
K
-
K
---
Y
A
C
V
S
L
V
-
G
G
T
D
F
R
A
A
M
N
K
-
M
-
N
K
L
R
P
----
N
--
I
V
I
A
T
P
G
R
L
I
D
-
V
L
E
K
Y
--
S
N
K
F
---
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
L
E
T
I
S
----
G
--
I
L
----
N
-------
E
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
NK
K
E
C
L
F
L
D
T
V
D
K
----
N
E
PE
A
H
E
R
I
D
Q
-
S
V
V
-
I
S
-
E
-
K
-
F
-
A
----
N
S
I
F
A
A
V
E
H
I
K
K
-
Q
-
I
-
K
E
R
D
SN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
---
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
--------
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
--
Y
E
P
S
E
E
I
--------------------------------------------------------------------
22
PsiBlast_CBE
83.94
36%
-104
- C4 -
2DB3
3
VASA1_DROME
C:
[58-430]
--
F
T
S
A
D
L
R
D
-
I
-
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
--
L
E
D
P
H
E
-------------
L
E
L
G
R
P
---
Q
-------------
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
---
K
F
A
F
E
S
----
Y
-
L
---
K
I
G
I
V
-
Y
-
G
G
T
S
F
R
H
Q
N
E
C
-
I
-
T
R
-
G
C
----
H
--
V
V
I
A
T
P
G
R
L
L
D
-
F
V
D
R
T
--
F
I
T
F
---
E
D
T
-
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
S
E
D
M
R
R
I
M
----
T
--
H
V
----
T
-------
M
R
PE
H
-------
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
--
K
N
Y
V
F
V
A
I
G
I
V
----
G
G
--
A
C
S
D
V
K
Q
-
T
I
Y
E
V
N
-
K
-
Y
-
A
-
K
----
R
S
K
L
I
---
E
I
L
--
S
-
E
-
Q
A
D
----
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
---
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
FDPEKDRA
I
-
A
-
A
D
-
L
-
V
K
I
L
E
G
----
S
G
Q
T
V
-----
P
D
F
--------------------------------------------------------------------------
14
PsiBlast_PDB
83.84
35%
-126
- C4 -
4CT4
3
DDX6_HUMAN
B:
[7-367]
--
F
E
D
Y
C
L
K
R
-
E
-
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
--
S
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
--
D
L
K
------------------
K
D
N
I
---
Q
-------------
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
---
Q
V
S
K
H
M
----
G
G
A
---
K
V
M
A
T
-
T
-
G
G
T
N
L
R
D
D
I
M
R
-
L
-
D
D
-
T
V
----
H
--
V
V
I
A
T
P
G
R
I
L
D
-
L
I
K
K
G
--
V
A
K
V
---
D
H
V
-
Q
M
I
V
L
D
E
A
D
K
L
L
-
S
--
Q
-
D
-
F
V
Q
I
M
E
D
I
I
----
L
--
T
L
----
P
-------
K
N
--
R
-------
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
--
Q
K
P
Y
E
I
N
L
M
E
E
----
L
T
--
L
-
K
G
V
T
Q
-
Y
Y
A
Y
V
T
-
E
-
R
-
Q
-
K
----
V
H
C
L
N
---
T
L
F
S
-
R
-
L
-
Q
I
N
----
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
---
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
E
------
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
--------
I
-
T
-
Y
D
-
D
-
R
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
K
---------------------------------------------------------------------------------
52
PsiBlast_CBE
83.82
31%
-99
- C4 -
3I5Y
3
MS116_YEAST
A:
[77-477]
------
G
V
L
D
K
E
-
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
---
I
N
T
K
F
-------------
D
S
Q
Y
M
V
---
K
-------------
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
----
K
-
K
---
Y
A
C
V
S
L
V
-
G
G
T
D
F
R
A
A
M
N
K
-
M
-
N
K
L
R
P
----
N
--
I
V
I
A
T
P
G
R
L
I
D
-
V
L
E
K
Y
--
S
N
K
F
---
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
L
E
T
I
S
----
G
--
I
L
----
N
-------
E
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
NK
K
E
C
L
F
L
D
T
V
D
K
----
N
E
PE
A
H
E
R
I
D
Q
-
S
V
V
-
I
S
-
E
-
K
-
F
-
A
----
N
S
I
F
A
A
V
E
H
I
K
K
-
Q
-
I
-
K
E
R
D
SN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
---
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
--------
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
--
Y
E
P
S
E
E
I
--------------------------------------------------------------------
51
PsiBlast_CBE
83.78
31%
-101
- C4 -
3I61
4
MS116_YEAST
A:
[77-477]
------
G
V
L
D
K
E
-
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
---
I
N
T
K
F
-------------
D
S
Q
Y
M
V
---
K
-------------
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
----
K
-
K
---
Y
A
C
V
S
L
V
-
G
G
T
D
F
R
A
A
M
N
K
-
M
-
N
K
L
R
P
----
N
--
I
V
I
A
T
P
G
R
L
I
D
-
V
L
E
K
Y
--
S
N
K
F
---
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
L
E
T
I
S
----
G
--
I
L
----
N
-------
E
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
NK
K
E
C
L
F
L
D
T
V
D
K
----
N
E
PE
A
H
E
R
I
D
Q
-
S
V
V
-
I
S
-
E
-
K
-
F
-
A
----
N
S
I
F
A
A
V
E
H
I
K
K
-
Q
-
I
-
K
E
R
D
SN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
---
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
--------
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
--
Y
E
P
S
E
E
I
--------------------------------------------------------------------
5
PsiBlast_PDB
83.66
38%
-108
- C4 -
4PXA
5
DDX3X_HUMAN
A:
[66-437]
-
S
F
S
D
V
E
M
G
E
-
I
-
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
--
Y
S
D
G
P
G
-------------
E
A
L
R
A
M
---
K
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
---
K
F
S
Y
R
S
----
R
-
V
---
R
P
C
V
V
-
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
-
L
-
E
R
-
G
C
----
H
--
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
--
K
I
G
L
---
D
F
C
-
K
Y
L
V
L
D
E
A
D
R
M
L
-
V
--
M
-
G
-
F
E
P
Q
I
R
R
I
V
----
E
QD
T
M
----
P
-------
P
K
GV
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
--
D
E
Y
I
F
L
A
V
G
R
V
----
G
S
--
T
S
E
N
I
T
Q
-
K
V
V
W
V
E
-
E
-
S
-
D
-
K
----
R
S
F
L
L
---
D
L
L
N
-
A
-
T
G
K
D
S
----
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
---
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
--------
F
-
N
-
E
R
-
N
-
I
N
I
----------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.52
39%
-123
- C4 -
2I4I
1
DDX3X_HUMAN
A:
[16-379]
-
S
F
S
D
V
E
M
G
E
-
I
-
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
--
Y
S
D
G
P
G
-------------
E
A
L
R
A
M
---
K
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
---
K
F
S
Y
R
S
----
R
-
V
---
R
P
C
V
V
-
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
-
L
-
E
R
-
G
C
----
H
--
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
--
K
I
G
L
---
D
F
C
-
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
I
R
R
I
V
----
E
QD
T
M
----
P
-------
P
K
GV
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
--
D
E
Y
I
F
L
A
V
G
----------
T
S
E
N
I
T
Q
-
K
V
V
W
V
E
-
E
-
S
-
D
-
K
----
R
S
F
L
L
---
D
L
L
N
-
A
-
T
G
K
D
S
----
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
---
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
83.51
35%
-124
- C4 -
4CT4
2
DDX6_HUMAN
D:
[7-367]
--
F
E
D
Y
C
L
K
R
-
E
-
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
--
S
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
--
D
L
K
------------------
K
D
N
I
---
Q
-------------
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
---
Q
V
S
K
H
M
----
G
G
A
---
K
V
M
A
T
-
T
-
G
G
T
N
L
R
D
D
I
M
R
-
L
-
D
D
-
T
V
----
H
--
V
V
I
A
T
P
G
R
I
L
D
-
L
I
K
K
G
--
V
A
K
V
---
D
H
V
-
Q
M
I
V
L
D
E
A
D
K
L
L
-
S
--
Q
-
D
-
F
V
Q
I
M
E
D
I
I
----
L
--
T
L
----
P
-------
K
N
--
R
-------
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
--
Q
K
P
Y
E
I
N
L
M
E
E
----
L
T
--
L
-
K
G
V
T
Q
-
Y
Y
A
Y
V
T
-
E
-
R
-
Q
-
K
----
V
H
C
L
N
---
T
L
F
S
-
R
-
L
-
Q
I
N
----
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
---
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
----
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
E
------
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
--------
I
-
T
-
Y
D
-
D
-
R
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
K
---------------------------------------------------------------------------------
47
PsiBlast_CBE
83.50
32%
-121
- C4 -
3EWS
1
DD19B_HUMAN
A:
[63-442]
-
S
F
E
E
L
R
L
K
P
-
Q
-
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
-------
E
-------------
P
A
N
K
Y
P
---
Q
-------------
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
---
Q
M
G
K
F
Y
----
P
E
L
---
K
L
A
Y
A
-
V
-
R
G
-------
N
K
-
L
-
E
R
-
G
Q
KISE
Q
--
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
----
L
K
F
IDP
K
K
I
-
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
----
R
--
M
L
----
P
-------
R
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
--
P
D
P
N
V
I
K
L
K
R
E
----
E
E
--
T
L
D
T
I
K
Q
-
Y
Y
V
L
C
S
-
S
-
R
D
E
-
K
----
F
Q
A
L
C
---
N
L
Y
G
-
A
-
I
-
T
I
A
----
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
---
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
D
KDGNP
D
N
E
------
T
Y
L
H
R
I
G
R
----
G
K
R
G
L
A
V
N
M
--------
V
D
S
-
K
H
-
S
-
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
T
D
D
L
D
-------------------------------------------------------------------------
53
PsiBlast_CBE
83.28
31%
-100
- C4 -
3I5X
3
MS116_YEAST
A:
[77-477]
------
G
V
L
D
K
E
-
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
---
I
N
T
K
F
-------------
D
S
Q
Y
M
V
---
K
-------------
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
----
K
-
K
---
Y
A
C
V
S
L
V
-
G
G
T
D
F
R
A
A
M
N
K
-
M
-
N
K
L
R
P
----
N
--
I
V
I
A
T
P
G
R
L
I
D
-
V
L
E
K
Y
--
S
N
K
F
---
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
L
E
T
I
S
----
G
--
I
L
----
N
-------
E
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
NK
K
E
C
L
F
L
D
T
V
D
K
----
N
E
PE
A
H
E
R
I
D
Q
-
S
V
V
-
I
S
-
E
-
K
-
F
-
A
----
N
S
I
F
A
A
V
E
H
I
K
K
-
Q
-
I
-
K
E
R
D
SN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
---
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
--------
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
--
Y
E
P
S
E
E
I
--------------------------------------------------------------------
50
PsiBlast_CBE
83.01
31%
-100
- C4 -
3I62
4
MS116_YEAST
A:
[77-477]
------
G
V
L
D
K
E
-
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
SS
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
---
I
N
T
K
F
-------------
D
S
Q
Y
M
V
---
K
-------------
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
----
K
-
K
---
Y
A
C
V
S
L
V
-
G
G
T
D
F
R
A
A
M
N
K
-
M
-
N
K
L
R
P
----
N
--
I
V
I
A
T
P
G
R
L
I
D
-
V
L
E
K
Y
--
S
N
K
F
---
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
L
E
T
I
S
----
G
--
I
L
----
N
-------
E
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
NK
K
E
C
L
F
L
D
T
V
D
K
----
N
E
PE
A
H
E
R
I
D
Q
-
S
V
V
-
I
S
-
E
-
K
-
F
-
A
----
N
S
I
F
A
A
V
E
H
I
K
K
-
Q
-
I
-
K
E
R
D
SN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
---
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
--------
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
--
Y
E
P
S
E
E
I
--------------------------------------------------------------------
117
HHSearch
82.69
34%
-110
- C4 -
3FHT
4
DD19B_HUMAN
A:
[26-399]
-
S
F
E
E
L
R
L
K
P
-
Q
-
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
--
E
P
A
N
------------------
K
Y
P
---
Q
-------------
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
---
Q
M
G
K
F
Y
----
P
E
L
---
K
L
A
Y
A
-
V
-
R
G
N
---
K
L
E
R
G
-
Q
-
K
I
-
S
E
----
Q
--
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
L
K-
F
I
D
P
---
K
K
I
-
K
V
F
V
L
D
E
A
D
V
M
I
-
A
--
T
Q
G
-
H
Q
D
Q
S
I
R
I
Q
----
R
--
M
L
----
P
-------
R
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
--
P
D
P
N
V
I
K
L
K
R
E
----
E
E
--
T
L
D
T
I
K
Q
-
Y
Y
V
L
C
S
-
S
R
D
-
E
-
K
----
F
Q
A
L
C
---
N
L
Y
G
-
A
-
I
-
T
I
A
----
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
---
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
DKDGNP
D
N
E
------
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
--------
V
-
D
-
S
K
-
H
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
-------------------------------------------------------------------------------
44
PsiBlast_CBE
81.68
32%
-112
- C4 -
3FHT
4
DD19B_HUMAN
A:
[26-399]
-
S
F
E
E
L
R
L
K
P
-
Q
-
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
-------
E
-------------
P
A
N
K
Y
P
---
Q
-------------
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
---
Q
M
G
K
F
Y
----
P
E
L
---
K
L
A
Y
A
-
V
-
R
G
-------
N
K
-
L
-
E
R
-
G
Q
KISE
Q
--
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
----
L
K
F
IDP
K
K
I
-
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
----
R
--
M
L
----
P
-------
R
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
--
P
D
P
N
V
I
K
L
K
R
E
----
E
E
--
T
L
D
T
I
K
Q
-
Y
Y
V
L
C
S
-
S
-
R
D
E
-
K
----
F
Q
A
L
C
---
N
L
Y
G
-
A
-
I
-
T
I
A
----
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
---
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
DKDGNP
D
N
E
------
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
--------
V
D
S
-
K
H
-
S
-
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
-------------------------------------------------------------------------------
8
PsiBlast_PDB
81.10
34%
-112
- C4 -
2J0S
3
IF4A3_HUMAN
A:
[38-392]
-
T
F
D
T
M
G
L
R
E
-
D
-
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
--
D
I
Q
------------------
V
R
E
T
---
Q
-------------
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
---
A
L
G
D
Y
M
----
N
-
V
---
Q
C
H
A
C
-
I
-
G
G
T
N
V
G
E
D
I
R
K
-
L
-
D
Y
-
G
Q
----
H
--
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
R
--
S
L
R
T
---
R
A
I
-
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
----
R
--
Y
L
----
P
-------
P
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
--
T
D
P
I
R
I
L
V
K
R
D
----
E
L
--
T
L
E
G
I
K
Q
-
F
F
V
A
V
E
-
R
-
E
-
E
W
K
----
F
D
T
L
C
---
D
L
Y
D
-
T
-
L
-
T
I
T
----
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
---
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
--------
V
-
K
-
N
D
-
D
-
I
R
I
L
R
D
I
E
-----------------------------------------------------------------------------------------
35
PsiBlast_CBE
80.99
35%
-126
- C4 -
2VSX
1
IF4A_YEAST
A:
[24-369]
--
F
D
D
M
E
L
D
E
-
N
-
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
DT
S
V
K
A
P
Q
------------------------------------
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
---
A
L
A
F
H
M
----
D
-
I
---
K
V
H
A
C
-
I
-
G
-----------
L
-
R
D
-
A
-----
Q
--
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
R
--
R
F
R
T
---
D
K
I
-
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
----
T
--
L
L
----
P
-------
P
T
--
T
-------
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
--
R
N
P
V
R
I
L
V
K
K
D
----
E
L
--
T
L
E
G
I
K
Q
-
F
Y
V
N
V
E
-
E
-
E
-
E
Y
K
----
Y
E
C
L
T
---
D
L
Y
D
-
S
-
I
-
S
V
T
----
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
---
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
------
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
--------
V
-
T
-
N
E
-
D
-
V
------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
80.85
35%
-126
- C4 -
2VSX
1
IF4A_YEAST
B:
[24-369]
--
F
D
D
M
E
L
D
E
-
N
-
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
DT
S
V
K
A
P
Q
------------------------------------
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
---
A
L
A
F
H
M
----
D
-
I
---
K
V
H
A
C
-
I
-
G
-----------
L
-
R
D
-
A
-----
Q
--
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
R
--
R
F
R
T
---
D
K
I
-
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
----
T
--
L
L
----
P
-------
P
T
--
T
-------
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
--
R
N
P
V
R
I
L
V
K
K
D
----
E
L
--
T
L
E
G
I
K
Q
-
F
Y
V
N
V
E
-
E
-
E
-
E
Y
K
----
Y
E
C
L
T
---
D
L
Y
D
-
S
-
I
-
S
V
T
----
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
---
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
------
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
--------
V
-
T
-
N
E
-
D
-
V
------------------------------------------------------------------------------------------------
116
HHSearch
80.82
33%
-126
- C4 -
1XTI
4
DX39B_HUMAN
A:
[9-370]
-
G
F
R
D
F
L
L
K
P
-
E
-
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
--
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
--
E
P
V
T
------------------
G
Q
V
---
S
-------------
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
---
R
F
S
K
Y
M
P---
N
-
V
---
K
V
A
V
F
-
F
-
G
G
L
S
I
K
K
D
E
E
V
L
K
-
K
N
-
C
P
----
H
--
I
V
V
G
T
P
G
R
I
L
A
-
L
A
R
N
K
--
S
L
N
L
---
K
H
I
-
K
H
F
I
L
D
E
C
D
K
M
L
-
E
--
Q
L
D
-
M
R
R
D
V
Q
E
I
F
----
R
--
M
T
----
P
-------
H
E
--
K
-------
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
--
Q
D
P
M
E
I
F
V
D
D
E
T---
K
L
--
T
L
H
G
L
Q
Q
-
Y
Y
V
K
L
K
-
D
-
N
-
E
-
K
----
N
R
K
L
F
---
D
L
L
D
-
V
-
L
-
E
F
N
----
Q
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
---
E
Q
---
N
F
P
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
E
------
D
S
D
------
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
--------
V
-
S
-
D
E
N
D
-
A
K
I
L
N
D
V
Q
D
R
F
--------------------------------------------------------------------------------------
48
PsiBlast_CBE
80.73
32%
-110
- C4 -
3G0H
4
DD19B_HUMAN
A:
[42-416]
-
S
F
E
E
L
R
L
K
P
-
Q
-
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
-------
E
-------------
P
A
N
K
Y
P
---
Q
-------------
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
---
Q
M
G
K
F
Y
----
P
E
L
---
K
L
A
Y
A
-
V
-
R
G
-------
N
K
-
L
-
E
R
-
G
Q
KISE
Q
--
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
----
L
K
F
IDP
K
K
I
-
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
----
R
--
M
L
----
P
-------
R
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
--
P
D
P
N
V
I
K
L
K
R
E
----
E
E
--
T
L
D
T
I
K
Q
-
Y
Y
V
L
C
S
-
S
-
R
D
E
-
K
----
F
Q
A
L
C
---
N
L
Y
G
-
A
-
I
-
T
I
A
----
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
---
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
DKDGNP
D
N
E
------
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
--------
V
D
S
-
K
H
-
S
-
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
------------------------------------------------------------------------------
43
PsiBlast_CBE
80.69
32%
-113
- C4 -
3FHT
6
DD19B_HUMAN
B:
[26-400]
-
S
F
E
E
L
R
L
K
P
-
Q
-
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
-------
E
-------------
P
A
N
K
Y
P
---
Q
-------------
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
---
Q
M
G
K
F
Y
----
P
E
L
---
K
L
A
Y
A
-
V
-
R
G
-------
N
---------KISE
Q
--
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
----
L
K
F
IDP
K
K
I
-
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
----
R
--
M
L
----
P
-------
R
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
--
P
D
P
N
V
I
K
L
K
R
E
----
E
E
--
T
L
D
T
I
K
Q
-
Y
Y
V
L
C
S
-
S
-
R
D
E
-
K
----
F
Q
A
L
C
---
N
L
Y
G
-
A
-
I
-
T
I
A
----
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
---
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
DKDGNP
D
N
E
------
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
--------
V
D
S
-
K
H
-
S
-
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
------------------------------------------------------------------------------
19
PsiBlast_PDB
80.41
35%
-118
- C4 -
4BRW
2
DHH1_YEAST
A:
[2-358]
-
T
F
E
D
F
Y
L
K
R
-
E
-
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
--
T
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
-------
T
L
E
K
V
K
-------------
P
K
L
N
K
I
---
Q
-------------
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
---
T
L
G
K
H
C
----
G
-
I
---
S
C
M
V
T
-
T
-
G
G
T
N
L
R
D
D
I
L
R
-
L
-
N
E
-
T
V
----
H
--
I
L
V
G
T
P
G
R
V
L
D
-
L
A
S
R
K
--
V
A
D
L
---
S
D
C
-
S
L
F
I
M
D
E
A
D
K
M
L
-
S
--
R
-
D
-
F
K
T
I
I
E
Q
I
L
----
S
--
F
L
----
P
-------
P
T
--
H
-------
Q
S
L
L
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
--
H
K
P
Y
E
I
N
L
M
E
E
----
L
T
---
L
K
G
I
T
Q
-
Y
Y
A
F
V
E
-
E
-
R
-
Q
-
K
----
L
H
C
L
N
---
T
L
F
S
-
K
-
L
-
Q
I
N
----
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
---
D
L
---
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
E
------
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
--------
I
-
N
-
W
N
-
D
-
R
F
N
L
Y
K
I
E
Q
E
L
G
-------------------------------------------------------------------------------------
37
PsiBlast_CBE
80.26
35%
-126
- C4 -
2VSO
1
IF4A_YEAST
A:
[24-369]
--
F
D
D
M
E
L
D
E
-
N
-
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
DT
S
V
K
A
P
Q
------------------------------------
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
---
A
L
A
F
H
M
----
D
-
I
---
K
V
H
A
C
-
I
-
G
-----------
L
-
R
D
-
A
-----
Q
--
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
R
--
R
F
R
T
---
D
K
I
-
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
----
T
--
L
L
----
P
-------
P
T
--
T
-------
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
--
R
N
P
V
R
I
L
V
K
K
D
----
E
L
--
T
L
E
G
I
K
Q
-
F
Y
V
N
V
E
-
E
-
E
-
E
Y
K
----
Y
E
C
L
T
---
D
L
Y
D
-
S
-
I
-
S
V
T
----
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
---
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
------
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
--------
V
-
T
-
N
E
-
D
-
V
------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
80.24
32%
-121
- C4 -
3RRN
2
DBP5_YEAST
A:
[6-370]
-
S
F
D
E
L
G
L
A
P
-
E
-
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
--
N
P
E
D
A
------------------
S
P
---
Q
-------------
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
---
E
M
G
K
F
T
----
K
-
I
---
T
S
Q
L
--------
I
V
P
D
S
F
E
-
K
-
N
K
-
Q
I
----
N
AQ
V
I
V
G
T
P
G
T
V
L
D
-
L
M
R
R
K
--
L
M
Q
L
---
Q
K
I
-
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
----
R
--
F
L
----
P
-------
K
D
--
T
-------
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
--
P
N
A
N
T
L
E
L
Q
------------
D
A
I
K
Q
L
Y
M
D
C
K
N
-
E
-
A
-
D
-
K
----
F
D
V
L
T
---
E
L
Y
G
-
V
-
M
-
T
I
G
----
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
---
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
------
L
A
N
GQAD
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
--------
V
-
H
D
K
N
-
S
-
F
N
I
L
S
A
I
Q
K
Y
F
G
-------------------------------------------------------------------------------------
33
PsiBlast_CBE
80.24
35%
-125
- C4 -
1XTI
4
DX39B_HUMAN
A:
[14-357]
-------
L
L
K
-
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
--
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
-------
E
-------------
P
V
T
G
Q
V
---
S
-------------
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
---
R
F
S
K
Y
M
----
P
N
V
---
K
V
A
V
F
-
F
-
G
G
L
S
I
K
K
D
E
E
V
-
L
-
K
K
-
N
C
P---
H
--
I
V
V
G
T
P
G
R
I
L
A
-
L
A
R
N
K
--
S
L
N
L
---
K
H
I
-
K
H
F
I
L
D
E
C
D
K
M
L
-
E
Q-
L
-
D
-
M
R
R
D
V
Q
E
I
F
----
R
--
M
T
----
P
-------
H
E
--
K
-------
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
--
Q
D
P
M
E
I
F
V
D
D
E
----
T
K
L-
T
L
H
G
L
Q
Q
-
Y
Y
V
K
L
K
-
D
-
N
-
E
-
K
----
N
R
K
L
F
---
D
L
L
D
-
V
-
L
-
E
F
N
----
Q
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
---
E
Q
---
N
F
P
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
E
------
D
S
D
------
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
--------
V
---
S
D
-
E
--------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
80.16
35%
-127
- C4 -
2VSO
1
IF4A_YEAST
B:
[24-369]
--
F
D
D
M
E
L
D
E
-
N
-
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
DT
S
V
K
A
P
Q
------------------------------------
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
---
A
L
A
F
H
M
----
D
-
I
---
K
V
H
A
C
-
I
-
G
-----------
L
-
R
D
-
A
-----
Q
--
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
R
--
R
F
R
T
---
D
K
I
-
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
----
T
--
L
L
----
P
-------
P
T
--
T
-------
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
--
R
N
P
V
R
I
L
V
K
K
D
----
E
L
--
T
L
E
G
I
K
Q
-
F
Y
V
N
V
E
-
E
-
E
-
E
Y
K
----
Y
E
C
L
T
---
D
L
Y
D
-
S
-
I
-
S
V
T
----
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
---
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
------
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
--------
V
-
T
-
N
E
-
D
-
V
------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
79.83
32%
-118
- C4 -
3PEW
9
DBP5_YEAST
A:
[6-370]
-
S
F
D
E
L
G
L
A
P
-
E
-
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
--
N
P
E
D
A
------------------
S
P
---
Q
-------------
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
---
E
M
G
K
F
T
----
K
-
I
---
T
S
Q
L
--------
I
V
P
D
S
F
E
-
K
-
N
K
-
Q
I
----
N
AQ
V
I
V
G
T
P
G
T
V
L
D
-
L
M
R
R
K
--
L
M
Q
L
---
Q
K
I
-
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
----
R
--
F
L
----
P
-------
K
D
--
T
-------
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
--
P
N
A
N
T
L
E
L
Q
T
N
----
E
V
--
N
V
D
A
I
K
Q
L
Y
M
D
C
K
N
-
E
-
A
-
D
-
K
----
F
D
V
L
T
---
E
L
Y
G
-
V
-
M
-
T
I
G
----
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
---
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
------
L
A
N
GQAD
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
--------
V
-
H
D
K
N
-
S
-
F
N
I
L
S
A
I
Q
K
Y
F
G
-------------------------------------------------------------------------------------
42
PsiBlast_CBE
79.63
32%
-119
- C4 -
3PEY
11
DBP5_YEAST
A:
[6-370]
-
S
F
D
E
L
G
L
A
P
-
E
-
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
--
N
P
E
D
A
------------------
S
P
---
Q
-------------
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
---
E
M
G
K
F
T
----
K
-
I
---
T
S
Q
L
--------
I
V
P
D
S
F
E
-
K
-
N
K
-
Q
I
----
N
AQ
V
I
V
G
T
P
G
T
V
L
D
-
L
M
R
R
K
--
L
M
Q
L
---
Q
K
I
-
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
----
R
--
F
L
----
P
-------
K
D
--
T
-------
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
--
P
N
A
N
T
L
E
L
Q
T
N
----
E
V
--
N
V
D
A
I
K
Q
L
Y
M
D
C
K
N
-
E
-
A
-
D
-
K
----
F
D
V
L
T
---
E
L
Y
G
-
L
-
M
-
T
I
G
----
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
---
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
------
L
A
N
GQAD
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
--------
V
-
H
D
K
N
-
S
-
F
N
I
L
S
A
I
Q
K
Y
F
G
-------------------------------------------------------------------------------------
119
HHSearch
77.44
33%
-109
- C4 -
3PEY
11
DBP5_YEAST
A:
[6-359]
-
S
F
D
E
L
G
L
A
P
-
E
-
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
--
N
P
E
D
------------------
A
S
P
---
Q
-------------
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
---
E
M
G
K
F
T
----
K
-
I
---
T
S
Q
L
I
-
V
-
P
D
S
F
E
----
K
N
-
K
-
Q
I
-
N
A
----
Q
--
V
I
V
G
T
P
G
T
V
L
D
-
L
M
R
R
K
--
L
M
Q
L
---
Q
K
I
-
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
-
Q
G
L
G
D
Q
C
I
R
V
K
----
R
--
F
L
----
P
-------
K
D
--
T
-------
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
--
P
N
A
N
T
L
E
L
Q
T
N
----
E
V
--
N
V
D
A
I
K
Q
-
L
Y
M
D
C
K
-
N
E
A
-
D
-
K
----
F
D
V
L
T
---
E
L
Y
G
-
L
-
M
-
T
I
G
----
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
---
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
A
------
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
--------
V
-
H
-
D
K
-
N
-
S
F
-----------------------------------------------------------------------------------------------
120
HHSearch
76.76
32%
-99
- C4 -
3I5X
3
MS116_YEAST
A:
[78-458]
------
V
L
D
K
-
E
-
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
--
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
--
I
N
T
K
F
--------------
D
S
Q
Y
M
V
---
K
-------------
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
---
K
I
H
D
M
N
Y---
G
-
L
KKY
A
C
V
S
L
-
V
-
G
G
T
D
F
R
A
A
M
N
K
-
M
N
K
L
-
R
P
----
N
--
I
V
I
A
T
P
G
R
L
I
D
-
V
L
E
K
Y
S-
N
K
F
F
---
R
F
V
-
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
L
E
T
I
S
----
G
--
I
L
----
N
E
K
NSKSA
D
N
--
I
-------
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
--
N
K
K
E
C
L
F
L
D
T
V
DKNE
P
E
--
A
H
E
R
I
D
Q
-
S
V
V
I
S
E
-
K
F
A
-
N
-
S
I
F
A
A
V
E
H
I
K
---
K
Q
I
K
E
R
-
D
-
S
N
Y
----
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
---
N
E
FKK
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
--------
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
-----------------------------------------------------------------------------------------
124
HHSearch
76.48
32%
-97
- C4 -
3SQW
3
MS116_YEAST
A:
[26-407]
-----
G
V
L
D
K
-
E
-
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
--
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
--
I
N
T
K
F
--------------
D
S
Q
Y
M
V
---
K
-------------
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
---
K
I
H
D
M
N
YGLK
K
-
Y
---
A
C
V
S
L
-
V
-
G
G
T
D
F
R
A
A
M
N
K
-
M
N
K
L
-
R
P
----
N
--
I
V
I
A
T
P
G
R
L
I
D
-
V
L
E
K
Y
S-
N
K
F
F
---
R
F
V
-
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
-
F
R
D
D
L
E
T
I
S
----
G
--
I
L
----
N
E
K
NSKSA
D
N
--
I
-------
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
--
N
K
K
E
C
L
F
L
D
T
V
DKNE
P
E
--
A
H
E
R
I
D
Q
-
S
V
V
I
S
E
K
F
-
A
-
N
-
S
I
F
A
A
V
E
H
I
K
---
K
Q
I
K
E
R
-
D
-
S
N
Y
----
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
---
N
E
FKK
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
--------
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
-----------------------------------------------------------------------------------------
74
PsiBlast_CBE
63.55
37%
-122
- C4 -
4PX9
1
DDX3X_HUMAN
A:
[66-290]
-
S
F
S
D
V
E
M
G
E
-
I
-
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
--
Y
S
D
G
P
G
-------------
E
A
L
R
A
M
---
K
ENGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
---
K
F
S
Y
R
S
----
R
-
V
---
R
P
C
V
V
-
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
-
L
-
E
R
-
G
C
----
H
--
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
--
K
I
G
L
---
D
F
C
-
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
I
R
R
I
V
----
E
QD
T
M
----
P
-------
P
K
GV
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
--
D
E
Y
I
F
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
63.29
37%
-122
- C4 -
4PX9
1
DDX3X_HUMAN
C:
[66-290]
-
S
F
S
D
V
E
M
G
E
-
I
-
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
--
Y
S
D
G
P
G
-------------
E
A
L
R
A
M
---
K
ENGRYGRRKQYPI
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
---
K
F
S
Y
R
S
----
R
-
V
---
R
P
C
V
V
-
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
-
L
-
E
R
-
G
C
----
H
--
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
--
K
I
G
L
---
D
F
C
-
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
I
R
R
I
V
----
E
QD
T
M
----
P
-------
P
K
GV
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
--
D
E
Y
I
F
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
63.04
37%
-120
- C4 -
4PX9
1
DDX3X_HUMAN
B:
[66-290]
-
S
F
S
D
V
E
M
G
E
-
I
-
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
--
Y
S
D
G
P
G
-------------
E
A
L
R
A
M
---
K
ENGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
---
K
F
S
Y
R
S
----
R
-
V
---
R
P
C
V
V
-
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
-
L
-
E
R
-
G
C
----
H
--
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
--
K
I
G
L
---
D
F
C
-
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
I
R
R
I
V
----
E
QD
T
M
----
P
-------
P
K
GV
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
--
D
E
Y
I
F
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
62.53
43%
-122
- C4 -
3BER
4
DDX47_HUMAN
A:
[44-248]
-
T
F
K
D
L
G
V
T
D
-
V
-
L
C
E
A
C
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
P
L
A
L
--
Q
--
G
--
R
D
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
I
L
N
A
L
---
L
E
T
P
Q
-----------------
R
L
---
F
-------------
A
L
V
L
T
P
T
R
E
L
A
F
Q
I
S
E
Q
F
E
---
A
L
G
S
S
I
----
G
-
V
---
Q
S
A
V
I
-
V
-
G
G
I
D
S
M
S
Q
S
L
A
-
L
-
A
K
-
K
P
----
H
--
I
I
I
A
T
P
G
R
L
I
D
H
L
E
N
T
K
--
G
F
N
L
---
R
A
L
-
K
Y
L
V
M
D
E
A
D
R
I
L
-
N
--
M
-
D
-
F
E
T
E
V
D
K
I
L
----
K
--
V
I
----
P
-------
R
D
--
R
-------
K
T
F
L
F
S
A
T
M
T
K
K
V
Q
K
L
Q
R
A
A
L
--
K
N
P
V
K
C
A
V
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
61.22
45%
-120
- C4 -
3NBF
2
?
A:
[1-205]
M
E
F
K
D
F
P
L
K
P
-
E
-
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
--
P
S
Q
-------------
E
R
G
R
K
P
---
R
-------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
----------
K
V
V
A
V
-
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
-
L
R
-
G
A
----
D
--
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
--
V
L
D
L
---
S
R
V
-
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
----
S
--
A
T
----
P
-------
P
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
--
K
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
60.54
45%
-130
- C4 -
3NBF
2
?
D:
[1-205]
M
E
F
K
D
F
P
L
K
P
-
E
-
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
----
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
--
P
S
Q
-------------
E
R
G
R
K
P
---
R
-------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
----------
K
V
V
A
V
-
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
-
L
R
-
G
A
----
D
--
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
--
V
L
D
L
---
S
R
V
-
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
----
S
--
A
T
----
P
-------
P
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
--
K
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
60.20
45%
-124
- C4 -
2GXS
3
?
A:
[1-205]
M
E
F
K
D
F
P
L
K
P
-
E
-
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
--
P
S
Q
-------------
E
R
G
R
K
P
---
R
-------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
----------
K
V
V
A
V
-
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
-
L
R
-
G
A
----
D
--
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
--
V
L
D
L
---
S
R
V
-
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
----
S
--
A
T
----
P
-------
P
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
--
K
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
60.13
45%
-125
- C4 -
2GXQ
2
?
A:
[1-205]
M
E
F
K
D
F
P
L
K
P
-
E
-
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
--
P
S
Q
-------------
E
R
G
R
K
P
---
R
-------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
----------
K
V
V
A
V
-
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
-
L
R
-
G
A
----
D
--
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
--
V
L
D
L
---
S
R
V
-
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
----
S
--
A
T
----
P
-------
P
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
--
K
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
60.09
45%
-125
- C4 -
3NBF
4
?
C:
[1-205]
M
E
F
K
D
F
P
L
K
P
-
E
-
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
--
P
S
Q
-------------
E
R
G
R
K
P
---
R
-------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
----------
K
V
V
A
V
-
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
-
L
R
-
G
A
----
D
--
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
--
V
L
D
L
---
S
R
V
-
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
----
S
--
A
T
----
P
-------
P
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
--
K
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
59.89
45%
-118
- C4 -
3NBF
2
?
B:
[2-205]
-
E
F
K
D
F
P
L
K
P
-
E
-
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
--
P
S
Q
-------------
E
R
G
R
K
P
---
R
-------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
----------
K
V
V
A
V
-
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
-
L
R
-
G
A
----
D
--
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
--
V
L
D
L
---
S
R
V
-
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
----
S
--
A
T
----
P
-------
P
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
--
K
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
59.82
45%
-128
- C4 -
3MWL
2
?
B:
[1-205]
M
E
F
K
D
F
P
L
K
P
-
E
-
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
--
P
S
Q
-------------
E
R
G
R
K
P
---
R
-------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
----------
K
V
V
A
V
-
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
-
L
R
-
G
A
----
D
--
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
--
V
L
D
L
---
S
R
V
-
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
----
S
--
A
T
----
P
-------
P
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
--
K
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
59.77
45%
-124
- C4 -
2GXS
4
?
B:
[1-205]
M
E
F
K
D
F
P
L
K
P
-
E
-
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
--
P
S
Q
-------------
E
R
G
R
K
P
---
R
-------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
----------
K
V
V
A
V
-
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
-
L
R
-
G
A
----
D
--
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
--
V
L
D
L
---
S
R
V
-
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
----
S
--
A
T
----
P
-------
P
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
--
K
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
58.81
33%
-126
- C4 -
3FMO
1
DD19B_HUMAN
B:
[93-297]
-
S
F
E
E
L
R
L
K
P
-
Q
-
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
-------
E
-------------
P
A
N
K
Y
P
---
Q
-------------
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
---
Q
M
G
K
F
Y
----
P
E
L
---
K
L
A
Y
A
-
V
-
R
G
-------
N
K
-
L
-
E
R
-
G
Q
KISE
Q
--
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
----
L
K
F
IDP
K
K
I
-
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
----
R
--
M
L
----
P
-------
R
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
--
P
D
P
N
V
I
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
58.62
42%
-133
- C4 -
3IUY
2
DDX53_HUMAN
A:
[31-228]
-------------
L
L
K
S
I
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
--
Q
--
G
--
I
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
H
L
--
D
---------------------
N
G
P
---
G
-------------
M
L
V
L
T
P
T
R
E
L
A
L
H
V
E
A
E
C
S
---
K
Y
S
-
Y
K
----
G
-
L
---
K
S
I
C
I
-
Y
-
G
------
Q
I
E
D
-
I
-
S
K
-
G
V
----
D
--
I
I
I
A
T
P
G
R
L
N
D
-
L
Q
M
N
N
--
S
V
N
L
---
R
S
I
-
T
Y
L
V
I
D
E
A
D
K
M
L
-
D
--
M
-
E
-
F
E
P
Q
I
R
K
I
L
----
L
--
D
V
----
R
-------
P
D
--
R
-------
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
--
K
D
P
M
I
V
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
58.62
45%
-122
- C4 -
3MWK
2
?
B:
[1-205]
M
E
F
K
D
F
P
L
K
P
-
E
-
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
--
P
S
Q
-------------
E
R
G
R
K
P
---
R
-------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
----------
K
V
V
A
V
-
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
-
L
R
-
G
A
----
D
--
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
--
V
L
D
L
---
S
R
V
-
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
----
S
--
A
T
----
P
-------
P
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
--
K
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
58.52
42%
-134
- C4 -
3IUY
2
DDX53_HUMAN
B:
[31-228]
-------------
L
L
K
S
I
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
--
Q
--
G
--
I
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
H
L
--
D
S
--------------------
N
G
P
---
G
-------------
M
L
V
L
T
P
T
R
E
L
A
L
H
V
E
A
E
C
S
---
K
Y
S
-
Y
K
----
G
-
L
---
K
S
I
C
I
-
Y
-
G
-----------------
V
----
D
--
I
I
I
A
T
P
G
R
L
N
D
-
L
Q
M
N
N
--
S
V
N
L
---
R
S
I
-
T
Y
L
V
I
D
E
A
D
K
M
L
-
D
--
M
-
E
-
F
E
P
Q
I
R
K
I
L
----
L
--
D
V
----
R
-------
P
D
--
R
-------
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
--
K
D
P
M
I
V
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
57.90
33%
-129
- C4 -
2OXC
1
DDX20_HUMAN
B:
[26-223]
--
F
E
S
L
L
L
S
R
-
P
-
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
--
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
S
L
--
V
L
E
N
L
------------------
S
T
---
Q
-------------
I
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
---
A
I
G
I
K
M
----
E
G
L
---
E
C
H
V
F
-
I
-
G
G
T
P
L
S
Q
D
K
T
R
-
L
-
K
K
--
C
----
H
--
I
A
V
G
S
P
G
R
I
K
Q
-
L
I
E
L
D
--
Y
L
N
P
---
G
S
I
-
R
L
F
I
L
D
E
A
D
K
L
L
-
E
--
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
----
S
--
S
L
----
P
-------
A
S
--
K
-------
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
--
R
D
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
57.85
37%
-120
- C4 -
1T6N
1
DX39B_HUMAN
A:
[20-220]
-------
L
L
K
-
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
--
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
-------
E
-------------
P
V
T
G
Q
V
---
S
-------------
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
---
R
F
S
K
Y
M
----
P
N
V
---
K
V
A
V
F
-
F
-
G
G
L
S
I
K
K
D
E
E
V
-
L
-
K
K
-
N
C
P---
H
--
I
V
V
G
T
P
G
R
I
L
A
-
L
A
R
N
K
--
S
L
N
L
---
K
H
I
-
K
H
F
I
L
D
E
C
D
K
M
L
-
E
Q-
L
-
D
-
M
R
R
D
V
Q
E
I
F
----
R
--
M
T
----
P
-------
H
E
--
K
-------
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
--
Q
D
P
M
E
I
F
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
57.46
37%
-122
- C4 -
1T6N
1
DX39B_HUMAN
B:
[20-220]
-------
L
L
K
-
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
--
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
-------
E
-------------
P
V
T
G
Q
V
---
S
-------------
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
---
R
F
S
K
Y
M
----
P
N
V
---
K
V
A
V
F
-
F
-
G
G
L
S
I
K
K
D
E
E
V
-
L
-
K
K
-
N
C
P---
H
--
I
V
V
G
T
P
G
R
I
L
A
-
L
A
R
N
K
--
S
L
N
L
---
K
H
I
-
K
H
F
I
L
D
E
C
D
K
M
L
-
E
Q-
L
-
D
-
M
R
R
D
V
Q
E
I
F
----
R
--
M
T
----
P
-------
H
E
--
K
-------
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
--
Q
D
P
M
E
I
F
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
57.09
33%
-127
- C4 -
2OXC
1
DDX20_HUMAN
A:
[26-223]
--
F
E
S
L
L
L
S
R
-
P
-
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
--
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
S
L
--
V
L
E
N
L
------------------
S
T
---
Q
-------------
I
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
---
A
I
G
I
K
M
----
E
G
L
---
E
C
H
V
F
-
I
-
G
G
T
P
L
S
Q
D
K
T
R
-
L
-
K
K
--
C
----
H
--
I
A
V
G
S
P
G
R
I
K
Q
-
L
I
E
L
D
--
Y
L
N
P
---
G
S
I
-
R
L
F
I
L
D
E
A
D
K
L
L
-
E
--
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
----
S
--
S
L
----
P
-------
A
S
--
K
-------
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
--
R
D
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
56.82
38%
-120
- C4 -
2PL3
6
DDX10_HUMAN
A:
[27-234]
--
F
S
D
F
P
L
S
K
-
K
-
T
L
K
G
L
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
L
A
L
--
Q
--
G
--
K
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
E
A
L
---
Y
R
L
Q
W
-------------
T
S
T
D
G
L
---
G
-------------
V
L
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
L
R
---
K
V
G
K
N
H
----
D
-
F
---
S
A
G
L
I
-
I
-
G
G
--
L
K
H
E
A
E
R
-
I
--
N
-
N
I
----
N
--
I
L
V
C
T
P
G
R
L
L
Q
--
H
M
D
E
--
T
V
S
F
HA-
T
D
L
-
Q
M
L
V
L
D
E
A
D
R
I
L
-
D
--
M
-
G
-
F
A
D
T
M
N
A
V
I
----
E
--
N
L
----
P
-------
K
K
--
R
-------
Q
T
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
--
K
N
P
E
Y
V
W
V
H
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
55.44
40%
-122
- C4 -
3FE2
4
DDX5_HUMAN
B:
[52-237]
-------------------------
P
T
A
I
Q
A
Q
G
W
P
V
A
L
--
S
--
G
--
L
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
H
I
--
N
H
Q
P
F
L
-------------
E
R
G
D
G
P
---
I
-------------
C
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
---
E
Y
C
R
A
C
----
R
-
L
---
K
S
T
C
I
-
Y
-
G
G
A
P
K
G
P
Q
I
R
D
-
L
-
E
R
-
G
V
----
E
--
I
C
I
A
T
P
G
R
L
I
D
-
F
L
E
C
G
--
K
T
N
L
---
R
R
T
-
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
I
R
K
I
V
----
D
--
Q
I
----
R
-------
P
D
--
R
-------
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
--
K
D
Y
I
H
I
N
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
53.85
40%
-121
- C4 -
3FE2
2
DDX5_HUMAN
A:
[52-237]
-------------------------
P
T
A
I
Q
A
Q
G
W
P
V
A
L
--
S
--
G
--
L
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
H
I
--
N
H
Q
P
F
L
-------------
E
R
G
D
G
P
---
I
-------------
C
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
---
E
Y
C
R
A
C
----
R
-
L
---
K
S
T
C
I
-
Y
-
G
G
A
P
K
G
P
Q
I
R
D
-
L
-
E
R
-
G
V
----
E
--
I
C
I
A
T
P
G
R
L
I
D
-
F
L
E
C
G
--
K
T
N
L
---
R
R
T
-
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
I
R
K
I
V
----
D
--
Q
I
----
R
-------
P
D
--
R
-------
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
--
K
D
Y
I
H
I
N
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
51.65
36%
-110
- C4 -
3DKP
4
DDX52_HUMAN
A:
[40-242]
-------------
L
L
Q
N
I
L
D
A
G
F
Q
M
P
T
P
I
Q
M
Q
A
I
P
V
M
L
--
H
--
G
--
R
E
L
L
A
S
A
P
T
G
S
G
K
T
L
A
F
S
I
P
I
L
M
Q
L
--
K
----
Q
-------------
P
A
N
K
G
F
---
R
-------------
A
L
I
I
S
P
T
R
E
L
A
S
Q
I
H
R
E
L
I
---
K
I
S
E
G
T
----
G
-
F
---
R
I
H
M
I
-
H
K
A
A
V
A
A
K
K
F
G
P
K
-
S
-
S
K
-
K
F
----
D
--
I
L
V
T
T
P
N
R
L
I
Y
-
L
L
K
Q
D
PP
G
I
D
L
---
A
S
V
-
E
W
L
V
V
D
E
S
D
K
L
F
-
E
D
G--
G
-
F
R
D
Q
L
A
S
I
F
L
---
A
--
C
T
----
S
-------
H
K
--
V
-------
R
R
A
M
F
S
A
T
F
A
Y
D
V
E
Q
W
C
K
L
N
L
--
D
N
V
I
S
V
S
I
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
34.74
31%
-82
- C4 -
4DB2
4
MS116_YEAST
C:
[35-171]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
NEF
K
K
---
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
--------
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
--
Y
E
P
S
E
E
I
--------------------------------------------------------------------
99
PsiBlast_CBE
31.09
31%
-92
- C4 -
4DB2
2
D:
[35-171]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
NEF
K
K
---
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
---------
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
------
N
Y
I
H
R
I
G
----------
S
V
L
F
--------
I
-
C
-
K
D
-
E
-
L
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
--
Y
E
P
S
E
E
I
--------------------------------------------------------------------