@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3977: (2016-02-22 )
MSRSETLFNNAQKHIPGGVNSPVRAFKSVGGTPLFFKHAEGAYVLDEDDKRYVDYVGSWGPMILGHSHPDVLDAVRRQLDHGLSYGAPTALEVEMADLVCSMVPSMEMVRMVSSGTEATMSAIRLARGYTGRDSIIKFEGCYHGHSDSLLVKAGSGALTFGVPNSPGVPAAFAKHTLTLPFNDIEAVRKTLGEVGKEVACIIVEPVAGNMNCVPPAPGFLEGLREACDEHGVVLIFDEVMTGFRVALGGAQAYYGVTPDLSTFGKIIGGGMPVGAFGGKREIMQQISPLGPVYQAGTLSGNPLAMAAGLTTLRLISRPGFHDELTAYTTRMLDGLQQRADAAGIPFVTTQAGGMFGLYFSGADAIVTFEDVMASDVERFKRFFHLMLDGGVYLAPSAFEAGFTSIAHGDKELEITLNAAEKAFAALK
Atome Classification :
(60 SA)
--.........10........20........30........40........50........60........70.......---.80-....-.....90........100..-..--...110.......120.......130-----........140.......150.......160.-...-...170.......180.......190.......200.......210.......220.......230.......240.-......250.......260.......270.......280......-.--290.......300.......310.....-.-.320.......330.......340....---...-350.......360.......370.......380.......390.......400.......410.......420.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MSR
S
E
T
L
F
N
N
A
Q
K
HIPGGVN
S
P
V
R
A
F
K
SVGGT
P
L
F
F
KHAE
G
A
Y
V
LDEDD
K
R
Y
V
D
YVGSWG
P
M
ILGHSH
P
D
V
L
D
A
V
R
R
Q
---
L
D--HGLS-YGAP
T
A
L
E
V
E
M
A
D
L
V
C
S
MVP-
S
M
--
E
M
V
R
M
V
SSG
T
E
A
T
M
S
A
I
R
L
ARGYTG------RD
S
I
I
K
F
E
G
C
YHGHSD
S
L
L
V
KAGS
G
A
L
T
FGVP-NSP-GV
P
A
A
FA
K
H
T
L
T
LPF
N
D
I
E
A
V
R
K
T
L
G
E
VGK
E
V
A
C
I
I
V
EPVAGNMNCVPPA
P
G
F
L
E
G
L
R
E
A
C
D
EH
G
V
V
L
I
F
D
E
V
M
T
G
F
-
R
VALGGA
Q
A
Y
YGVTP
D
L
S
T
F
G
K
I
IGGGMPVGAFG
G
K
R
E
I
M
Q
QISP-L--GP
V
Y
QAGTLSGN
P
L
A
M
AAG
L
T
T
L
R
L
ISR-P-GF
H
D
E
L
T
A
Y
T
T
R
M
L
D
G
L
Q
Q
R
ADAAGI
P
F
---
V
T
T-QAG
G
M
F
G
L
Y
FSGA
D
A
I
V
T
F
E
D
V
M
A
S
D
V
E
R
F
K
R
F
F
H
L
M
LDG
G
V
Y
LA
P
S
A
F
E
A
G
F
T
S
IAHGD
K
E
L
E
I
T
L
N
A
A
E
K
A
F
A
ALK
6
PsiBlast_PDB
95.41
55%
-110
- C1 -
2HOZ
3
GSA_SYNP6
A:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
9
PsiBlast_PDB
93.69
55%
-106
- C1 -
3FQ7
2
GSA_SYNP6
A:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
12
PsiBlast_PDB
93.34
55%
-106
- C1 -
3FQ8
2
GSA_SYNP6
A:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
11
PsiBlast_PDB
93.34
55%
-108
- C1 -
3FQA
3
GSA_SYNP6
A:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
31
PsiBlast_CBE
93.05
55%
-105
- C1 -
3FQ8
2
GSA_SYNP6
B:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
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A
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F
L
E
G
L
R
E
I
T
L
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H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
29
PsiBlast_CBE
93.01
55%
-106
* C1 *
3FQ7
2
GSA_SYNP6
B:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
1
PsiBlast_PDB
93.01
54%
-107
- C1 -
3BS8
1
GSA_BACSU
A:
[14-435]
----
K
S
K
T
A
F
K
E
A
Q
K
L
M
P
G
G
V
N
S
P
V
R
A
F
K
S
V
D
M
D
P
I
F
M
E
R
G
K
G
S
K
I
F
D
I
D
G
N
E
Y
I
D
Y
V
L
S
W
G
P
L
I
L
G
H
T
N
D
R
V
V
E
S
L
K
K
V
---
A
E
--
Y
G
T
S
-
F
G
A
P
T
E
V
E
N
E
L
A
K
L
V
I
D
R
V
P
-
S
V
--
E
I
V
R
M
V
S
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
------
R
N
K
I
L
K
F
E
G
C
Y
H
G
H
G
D
S
L
L
I
K
A
G
S
G
V
A
T
L
G
L
P
-
D
S
P
-
G
V
P
E
G
I
A
K
N
T
I
T
V
P
Y
N
D
L
E
S
V
K
L
A
F
Q
Q
F
G
E
D
I
A
G
V
I
V
E
P
V
A
G
N
M
G
V
V
P
P
Q
E
G
F
L
Q
G
L
R
D
I
T
E
Q
Y
G
S
L
L
I
F
D
E
V
M
T
G
F
-
R
V
D
Y
N
C
A
Q
G
Y
F
G
V
T
P
D
L
T
C
L
G
K
V
I
G
G
G
L
P
V
G
A
Y
G
G
K
A
E
I
M
E
Q
I
A
P
-
S
--
G
P
I
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
L
E
T
L
K
Q
L
T
--
P
-
D
S
Y
K
N
F
I
K
K
G
D
R
L
E
E
G
I
S
K
A
A
E
A
H
G
I
P
H
---
T
F
N
-
R
A
G
S
M
I
G
F
F
F
T
N
-
E
P
V
I
N
Y
E
T
A
K
A
S
D
L
K
L
F
A
S
Y
Y
K
G
M
A
N
E
G
V
F
L
P
P
S
Q
F
E
G
L
F
L
S
T
A
H
T
D
E
D
I
E
N
T
I
Q
A
A
E
K
V
F
A
E
I
-
21
PsiBlast_CBE
93.00
55%
-105
- C1 -
4GSA
2
GSA_SYNP6
B:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
98
HHSearch
92.69
55%
-105
- C1 -
3FQ8
2
GSA_SYNP6
A:
[3-426]
--
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
-
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
--
26
PsiBlast_CBE
92.58
55%
-108
- C1 -
2HOZ
2
GSA_SYNP6
B:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
-------
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
23
PsiBlast_CBE
92.36
55%
-107
- C1 -
2GSA
2
GSA_SYNP6
B:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
8
PsiBlast_PDB
92.13
55%
-105
- C1 -
2HP2
3
GSA_SYNP6
A:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
7
PsiBlast_PDB
91.99
55%
-105
- C1 -
2HP1
3
GSA_SYNP6
A:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
4
PsiBlast_PDB
91.73
55%
-104
- C1 -
3GSB
3
GSA_SYNP6
A:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
24
PsiBlast_CBE
91.69
55%
-104
- C1 -
2HP2
3
GSA_SYNP6
B:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
22
PsiBlast_CBE
91.67
55%
-104
- C1 -
3GSB
3
GSA_SYNP6
B:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
120
Fugue
91.60
55%
-104
- C1 -
2GSA
2
GSA_SYNP6
A:
[6-432]
FK
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
10
PsiBlast_PDB
91.60
55%
-103
- C1 -
3USF
3
GSA_SYNE7
A:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
2
PsiBlast_PDB
91.47
55%
-104
- C1 -
2GSA
2
GSA_SYNP6
A:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
3
PsiBlast_PDB
91.23
55%
-105
- C1 -
4GSA
2
GSA_SYNP6
A:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
30
PsiBlast_CBE
90.92
55%
-105
- C1 -
3FQA
3
GSA_SYNP6
B:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-
S
S
P
-
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
28
PsiBlast_CBE
90.40
55%
-110
- C1 -
3USF
3
GSA_SYNE7
B:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
---------------------------
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
13
PsiBlast_PDB
90.09
55%
-103
- C1 -
2E7U
4
GSA_THET8
A:
[6-424]
-----
S
E
A
Y
F
Q
E
A
K
R
H
I
P
G
G
V
S
S
P
V
R
A
F
K
A
V
G
G
T
P
P
F
L
V
R
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
S
W
G
P
L
I
L
G
H
A
H
P
K
V
L
A
R
V
R
E
T
---
L
E
--
R
G
L
T
-
F
G
A
P
S
P
L
E
V
A
L
A
K
K
V
K
R
A
Y
P
-
F
V
--
D
L
V
R
F
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
------
R
P
Y
I
V
K
F
R
G
N
Y
H
G
H
A
D
G
L
L
V
E
A
G
S
G
A
L
T
L
G
V
P
-
S
S
A
-
G
V
P
E
E
Y
A
K
L
T
L
V
L
E
Y
N
D
P
E
G
L
R
E
V
L
K
R
R
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
V
L
V
P
T
E
D
F
L
K
A
L
H
E
A
-
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
-
R
L
A
F
G
G
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
K
V
A
P
-
L
--
G
P
V
Y
Q
A
G
T
L
S
G
N
P
L
A
M
A
A
G
L
A
T
L
E
L
L
E
E
N
P
-
G
Y
Y
A
Y
L
E
D
L
G
A
R
L
E
A
G
L
K
E
V
L
K
E
K
G
L
P
H
---
T
V
N
-
R
V
G
S
M
I
T
V
F
F
T
-
E
G
P
V
V
T
F
Q
D
A
R
R
T
D
T
E
L
F
K
R
F
F
H
G
L
L
D
R
G
I
Y
W
P
P
S
N
F
E
A
A
F
L
S
V
A
H
R
E
E
D
V
E
K
T
L
E
A
L
R
K
A
L
----
25
PsiBlast_CBE
90.01
55%
-110
- C1 -
2HP1
3
GSA_SYNP6
B:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
---
M
E
--
K
G
T
S
-
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
-
S
I
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
-------------------------------
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
-
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
---
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
-
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
99
HHSearch
88.78
55%
-102
- C1 -
2E7U
4
GSA_THET8
A:
[3-424]
--
R
P
I
S
E
A
Y
F
Q
E
A
K
R
H
I
P
G
G
V
S
S
P
V
R
A
F
K
A
V
G
G
T
P
P
F
L
V
R
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
S
W
G
P
L
I
L
G
H
A
H
P
K
V
L
A
R
V
R
E
T
---
L
E
--
R
G
L
T
-
F
G
A
P
S
P
L
E
V
A
L
A
K
K
V
K
R
A
Y
P
-
F
V
--
D
L
V
R
F
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
------
R
P
Y
I
V
K
F
R
G
N
Y
H
G
H
A
D
G
L
L
V
E
A
G
S
G
A
L
T
L
G
V
P
-
S
S
A
-
G
V
P
E
E
Y
A
K
L
T
L
V
L
E
Y
N
D
P
E
G
L
R
E
V
L
K
R
R
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
V
L
V
P
T
E
D
F
L
K
-
A
L
H
E
A
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
-
R
L
A
F
G
G
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
K
V
A
P
-
L
--
G
P
V
Y
Q
A
G
T
L
S
G
N
P
L
A
M
A
A
G
L
A
T
L
E
L
L
E
E
-
N
P
G
Y
Y
A
Y
L
E
D
L
G
A
R
L
E
A
G
L
K
E
V
L
K
E
K
G
L
P
H
---
T
V
N
-
R
V
G
S
M
I
T
V
F
F
T
E
G
-
P
V
V
T
F
Q
D
A
R
R
T
D
T
E
L
F
K
R
F
F
H
G
L
L
D
R
G
I
Y
W
P
P
S
N
F
E
A
A
F
L
S
V
A
H
R
E
E
D
V
E
K
T
L
E
A
L
R
K
A
L
----
14
PsiBlast_PDB
82.72
54%
-117
- C1 -
2CFB
1
GSA_THEEB
A:
[19-411]
----------------------------------
P
I
V
F
D
H
V
K
G
A
H
I
W
D
V
D
G
N
Q
Y
I
D
Y
V
G
S
W
G
P
A
I
V
G
H
A
H
P
E
V
I
D
A
L
H
A
A
---
L
E
--
K
G
T
S
-
F
G
A
P
C
L
L
E
N
I
L
A
E
M
V
I
A
A
V
P
-
S
V
--
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
Q
------
R
E
K
V
I
K
F
E
G
C
Y
H
G
H
A
------------------------------
A
T
L
T
A
P
Y
N
D
L
E
A
V
S
R
L
F
E
Q
Y
P
N
D
I
A
G
V
I
L
E
P
V
V
G
N
A
G
F
I
P
P
D
A
G
F
L
E
G
L
R
E
L
T
K
Q
Y
G
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
A
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
V
I
G
G
G
L
P
V
G
A
Y
G
G
R
A
E
I
M
K
M
V
A
P
-
A
--
G
P
-----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
I
L
S
R
-
P
-
G
S
Y
E
H
L
D
R
I
T
G
K
L
V
Q
G
L
L
D
A
A
R
E
F
G
H
E
V
---
C
G
G
-
H
I
S
G
M
F
G
L
F
F
T
-
A
G
P
V
T
N
Y
E
Q
A
K
Q
S
D
L
K
K
F
A
A
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
A
D
I
E
R
T
I
A
A
A
R
T
V
L
S
Q
L
-
33
PsiBlast_CBE
81.07
43%
-107
- C1 -
2ZSM
4
GSA_AERPE
B:
[10-422]
---
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
---
L
A
--
R
G
W
L
-
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
-
R
G
--
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
-
T
S
A
-
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
-
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
Y
---
T
I
N
-
R
V
E
S
M
M
Q
L
-
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
----------
17
PsiBlast_PDB
78.17
43%
-102
- C1 -
2ZSM
2
GSA_AERPE
A:
[10-422]
---
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
---
L
A
--
R
G
W
L
-
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
-
R
G
--
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
-
T
S
A
-
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
-
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
Y
---
T
I
N
-
R
V
E
S
M
M
Q
L
-
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
----------
15
PsiBlast_PDB
77.96
43%
-103
- C1 -
2EPJ
1
GSA_AERPE
A:
[10-422]
---
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
---
L
A
--
R
G
W
L
-
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
-
R
G
--
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
-
T
S
A
-
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
-
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
Y
---
T
I
N
-
R
V
E
S
M
M
Q
L
-
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
----------
16
PsiBlast_PDB
77.93
43%
-103
- C1 -
2ZSL
1
GSA_AERPE
A:
[10-422]
---
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
---
L
A
--
R
G
W
L
-
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
-
R
G
--
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
-
T
S
A
-
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
-
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
Y
---
T
I
N
-
R
V
E
S
M
M
Q
L
-
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
----------
32
PsiBlast_CBE
77.34
43%
-103
- C1 -
2ZSM
4
GSA_AERPE
C:
[10-422]
---
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
---
L
A
--
R
G
W
L
-
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
-
R
G
--
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
-
T
S
A
-
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
-
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
Y
---
T
I
N
-
R
V
E
S
M
M
Q
L
-
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
----------
102
HHSearch
77.33
43%
-101
- C1 -
2EPJ
1
GSA_AERPE
A:
[10-431]
---
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
A
V
--
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
---
L
A
--
R
G
W
L
-
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
-
R
G
--
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
-
T
S
A
-
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
-
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
Y
T
I
N
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
--
A
A
Q
---
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
-
49
PsiBlast_CBE
69.01
33%
-105
- C1 -
4AO9
2
BFAT_VARPD
A:
[44-420]
-----
S
Q
R
Q
F
E
A
Q
A
R
Y
M
P
G
A
N
S
R
S
V
L
F
Y
A
P
F
---
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
---
M
Q
--
G
G
I
N
-
L
T
G
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
-
Q
I
--
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
------
R
R
K
I
V
V
F
S
G
G
Y
H
G
-----------
G
V
L
G
F
G
A
R
-
P
S
P
T
T
V
P
F
D
F
----
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
--
R
L
A
P
H
G
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
L
F
D
P
R
T
--
G
P
L
A
H
S
G
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F
T
-
P
-
E
A
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
M
---
Q
F
T
-
G
I
G
S
L
M
N
A
H
F
V
Q
G
D
-
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
-----------------------------
37
PsiBlast_CBE
69.01
35%
-99
- C1 -
2YKY
10
?
C:
[64-447]
------------
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
---
L
A
--
V
G
L
N
-
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
-
S
I
--
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
-----------
G
L
L
N
F
A
----
S
G
-
H
A
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
-
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
---
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
-
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
42
PsiBlast_CBE
68.87
35%
-101
- C1 -
2YKV
10
?
C:
[64-447]
------------
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
---
L
A
--
V
G
L
N
-
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
-
S
I
--
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
-----------
G
L
L
N
F
A
----
S
G
-
H
A
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
-
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
---
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
-
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
48
PsiBlast_CBE
68.83
33%
-108
- C1 -
4AO9
3
BFAT_VARPD
B:
[44-420]
-----
S
Q
R
Q
F
E
A
Q
A
R
Y
M
P
G
A
N
S
R
S
V
L
F
Y
A
P
F
---
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
---
M
Q
--
G
G
I
N
-
L
T
G
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
-
Q
I
--
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
------
R
R
K
I
V
V
F
S
G
G
Y
H
G
-----------
G
V
L
G
F
G
A
R
-
P
S
P
T
T
V
P
F
D
F
----
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
--
R
L
A
P
H
G
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
L
F
D
P
R
T
--
G
P
L
A
H
S
G
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F
T
-
P
-
E
A
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
M
---
Q
F
T
-
G
I
G
S
L
M
N
A
H
F
V
Q
G
D
-
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
-----------------------------
46
PsiBlast_CBE
68.58
33%
-108
- C1 -
4AOA
2
BFAT_VARPD
B:
[44-420]
-----
S
Q
R
Q
F
E
A
Q
A
R
Y
M
P
G
A
N
S
R
S
V
L
F
Y
A
P
F
---
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
---
M
Q
--
G
G
I
N
-
L
T
G
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
-
Q
I
--
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
------
R
R
K
I
V
V
F
S
G
G
Y
H
G
-----------
G
V
L
G
F
G
A
R
-
P
S
P
T
T
V
P
F
D
F
----
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
--
R
L
A
P
H
G
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
L
F
D
P
R
T
--
G
P
L
A
H
S
G
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F
T
-
P
-
E
A
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
M
---
Q
F
T
-
G
I
G
S
L
M
N
A
H
F
V
Q
G
D
-
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
-----------------------------
40
PsiBlast_CBE
68.37
35%
-98
- C1 -
2YKX
6
?
C:
[64-447]
------------
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
---
L
A
--
V
G
L
N
-
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
-
S
I
--
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
-----------
G
L
L
N
F
A
----
S
G
-
H
A
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
-
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
---
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
-
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
20
PsiBlast_PDB
67.99
35%
-99
- C1 -
2YKX
8
?
A:
[64-447]
------------
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
---
L
A
--
V
G
L
N
-
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
-
S
I
--
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
-----------
G
L
L
N
F
A
----
S
G
-
H
A
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
-
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
---
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
-
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
47
PsiBlast_CBE
67.59
33%
-107
- C1 -
4AOA
3
BFAT_VARPD
A:
[44-420]
-----
S
Q
R
Q
F
E
A
Q
A
R
Y
M
P
G
A
N
S
R
S
V
L
F
Y
A
P
F
---
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
---
M
Q
--
G
G
I
N
-
L
T
G
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
-
Q
I
--
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
------
R
R
K
I
V
V
F
S
G
G
Y
H
G
-----------
G
V
L
G
F
G
A
R
-
P
S
P
T
T
V
P
F
D
F
----
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
--
R
L
A
P
H
G
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
L
F
D
P
R
T
--
G
P
L
A
H
S
G
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F
T
-
P
-
E
A
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
M
---
Q
F
T
-
G
I
G
S
L
M
N
A
H
F
V
Q
G
D
-
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
-----------------------------
39
PsiBlast_CBE
67.55
35%
-97
- C1 -
2YKY
11
?
A:
[64-447]
------------
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
---
L
A
--
V
G
L
N
-
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
-
S
I
--
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
-----------
G
L
L
N
F
A
----
S
G
-
H
A
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
-
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
---
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
-
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
41
PsiBlast_CBE
67.32
35%
-100
- C1 -
2YKX
4
?
B:
[64-447]
------------
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
---
L
A
--
V
G
L
N
-
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
-
S
I
--
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
-----------
G
L
L
N
F
A
----
S
G
-
H
A
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
-
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
---
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
-
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
38
PsiBlast_CBE
67.14
35%
-99
- C1 -
2YKY
13
?
B:
[64-447]
------------
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
---
L
A
--
V
G
L
N
-
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
-
S
I
--
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
-----------
G
L
L
N
F
A
----
S
G
-
H
A
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
-
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
---
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
-
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
44
PsiBlast_CBE
67.09
35%
-98
- C1 -
2YKU
6
?
C:
[64-447]
------------
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
---
L
A
--
V
G
L
N
-
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
-
S
I
--
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
-----------
G
L
L
N
F
A
----
S
G
-
H
A
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
-
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
---
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
-
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
18
PsiBlast_PDB
66.92
35%
-97
- C1 -
2YKU
9
?
A:
[64-447]
------------
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
---
L
A
--
V
G
L
N
-
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
-
S
I
--
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
-----------
G
L
L
N
F
A
----
S
G
-
H
A
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
-
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
---
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
-
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
45
PsiBlast_CBE
64.53
35%
-98
- C1 -
2YKU
9
?
B:
[64-447]
------------
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
---
L
A
--
V
G
L
N
-
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
-
S
I
--
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
-----------
G
L
L
N
F
A
----
S
G
-
H
A
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
-
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
---
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
-
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
84
PsiBlast_CBE
41.43
31%
-90
- C1 -
4JEZ
12
ARGD_SALTY
B:
[47-320]
-----------------------------------------
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
---
G
E
---
T
L
W
-
H
T
S
R
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
-
A
T
FA
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
-
A
-------
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
---
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
---
S
A
-
F
-------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
-
P
------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
41.24
32%
-82
- C1 -
4JF1
9
ARGD_SALTY
B:
[47-320]
-----------------------------------------
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
--
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
------
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
-
A
-------
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
---
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
---
S
A
-
F
--
H
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
-
P
------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
40.86
32%
-82
- C1 -
2PB2
6
ARGD_SALTY
A:
[47-320]
-----------------------------------------
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
--
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
------
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
-
A
-------
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
---
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
---
S
A
-
F
------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
-
P
------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
40.48
32%
-83
- C1 -
4JF1
8
ARGD_SALTY
A:
[47-320]
-----------------------------------------
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
--
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
------
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
-
A
-------
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
---
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
---
S
A
-
F
--------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
-
P
------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
40.31
33%
-90
- C1 -
1WKG
2
ARGD_THET8
A:
[29-303]
-----------------------------------
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
---
A
E
T
L
M
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
L
--
N
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
G
------
R
K
---
K
F
V
A
A
M
R
G
F
S
G
R
T
M
---
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
-
F
L
P
--
L
V
E
P
V
E
F
I
P
Y
N
D
V
E
A
L
K
R
A
V
D
E
---
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
-
G
--
G
---
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
--------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
40.30
32%
-84
- C1 -
2PB0
5
ARGD_SALTY
A:
[47-320]
-----------------------------------------
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
--
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
------
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
-
A
-------
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
---
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
---
S
A
-
F
-------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
-
P
------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
40.13
33%
-85
- C1 -
1WKH
2
ARGD_THET8
B:
[29-303]
-----------------------------------
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
---
A
E
TL
M
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
L
--
N
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
G
------
R
K
---
K
F
V
A
A
M
R
G
F
S
G
R
T
M
---
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
-
F
L
P
--
L
V
E
P
V
E
F
I
P
Y
N
D
V
E
A
L
K
R
A
V
D
E
---
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
-
G
--
G
---
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
--------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
40.12
32%
-83
- C1 -
2PB0
5
ARGD_SALTY
B:
[47-320]
-----------------------------------------
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
--
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
------
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
-
A
-------
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
---
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
---
S
A
-
F
--
H
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
-
P
------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
39.68
32%
-82
- C1 -
4JEY
12
ARGD_SALTY
B:
[47-320]
-----------------------------------------
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
--
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
------
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
-
A
-------
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
---
H
T
C
A
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
---
S
A
-
F
--
H
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
-
P
------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
39.45
33%
-86
- C1 -
1VEF
2
ARGD_THET8
A:
[29-303]
-----------------------------------
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
---
A
E
T
L
M
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
L
--
N
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
G
------
R
K
---
K
F
V
A
A
M
R
G
F
S
G
R
T
M
---
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
-
F
L
P
--
L
V
E
P
V
E
F
I
P
Y
N
D
V
E
A
L
K
R
A
V
D
E
---
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
-
G
--
G
---
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
--------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
39.16
33%
-83
- C1 -
1WKH
2
ARGD_THET8
A:
[29-303]
-----------------------------------
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
---
A
E
T
L
M
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
L
--
N
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
G
------
R
K
---
K
F
V
A
A
M
R
G
F
S
G
R
T
M
---
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
-
F
L
P
--
L
V
E
P
V
E
F
I
P
Y
N
D
V
E
A
L
K
R
A
V
D
E
---
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
-
G
--
G
---
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
--------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
38.79
32%
-82
- C1 -
4JEY
13
ARGD_SALTY
A:
[47-320]
-----------------------------------------
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
--
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
------
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
-
A
-------
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
---
H
T
C
A
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
---
S
A
-
F
------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
-
P
------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
37.72
33%
-85
- C1 -
1VEF
2
ARGD_THET8
B:
[29-303]
-----------------------------------
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
---
A
E
TL
M
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
L
--
N
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
G
------
R
K
---
K
F
V
A
A
M
R
G
F
S
G
R
T
M
---
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
-
F
L
P
--
L
V
E
P
V
E
F
I
P
Y
N
D
V
E
A
L
K
R
A
V
D
E
---
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
-
G
--
G
---
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
--------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
36.80
33%
-81
- C1 -
1WKG
2
ARGD_THET8
B:
[29-303]
-----------------------------------
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
---
A
E
TL
M
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
L
--
N
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
G
------
R
K
---
K
F
V
A
A
M
R
G
F
S
G
R
T
M
---
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
-
F
L
P
--
L
V
E
P
V
E
F
I
P
Y
N
D
V
E
A
L
K
R
A
V
D
E
---
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
-
G
--
G
---
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
--------------------------------------------------------------------------------------------------------------------