@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4043: (2016-02-23 )
MIAAYQARCQARVDAALDALFVAPREELQRLYEAMRYSVMNGGKRVRPLLAYAACEALGGAPQRADAAACAVELIHAYSLVHDDLPAMDDDDLRRGQPTTHRAFDEATAILAADGLQALAFEVLADTRRNPQEHAVCLEMLTRLARAAGSAGMVGGQAIDLGSVGVALDQAALEVMHRHKTGALIEASVRLGALASGRAEPASLAALERYAEAIGLAFQVQDDILDVESDTATLGKTQGKDQAHNKPTYPALLGLEAAKGYALELRDLALAALDGFPPSADPLRQLARYIVERRN
Atome Classification :
(57 SA)
...-......10........20--....-.-...30........40........50........--60--.--....------.--..70........80........90........100.......110.......120-....--...130--....---...------.140.--......150.......160-.----.-.---....170..---.....180.......190....-...200........210.......220.......230.......240.......250.......260--------------------------------.........270....-.---..-280-.........290....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIA-
A
Y
Q
A
R
C
Q
A
R
V
D
A
A
L
D
A
L
F--VA
P
R
-
E
-
E
L
Q
R
L
Y
E
A
M
R
Y
S
V
MNGG
K
R
V
R
P
L
L
A
Y
A
A
C
E
A
LG--GA--P--QR
A
D
------
A
--
A
A
C
A
V
E
L
I
H
A
Y
S
L
V
HDDLPAMD
D
D
D
LRRGQPTT
H
R
A
F
D
E
A
T
A
I
L
A
AD
G
L
Q
A
L
A
F
E
-
V
L
A
D--TRR
N
P
---
Q
E
H
A
---
V
C
L
------
E
M
L
T
R
--
L
A
R
AAGSAGMVGG
Q
A
IDLG-S----
V
-
G
---
V
A
L
D
Q
A
A
L
E
---
V
M
H
RHKTG
A
L
I
E
A
S
V
R
LGALAS-GRAE
P
-
A
S
L
A
A
L
E
R
Y
A
E
AIG
L
A
F
Q
VQD
D
I
LDVESDTATLGKTQGKDQAHNKPTY
P
A
L
L
GLEAAK
G
----------------------------------
Y
A
L
E
L
R
D
L
A
L
A
A
LDGF-P---P
S
-
A
---
D
P
L
R
Q
L
A
R
Y
I
-
V
ERRN
1
PsiBlast_PDB
98.34
100%
-113
- C1 -
3ZMB
3
?
A:
[2-295]
M
I
A
-
A
Y
Q
A
R
C
Q
A
R
V
D
A
A
L
D
A
L
F
--
V
A
P
R
-
E
-
E
L
Q
R
L
Y
E
A
M
R
Y
S
V
M
N
G
G
K
R
V
R
P
L
L
A
Y
A
A
C
E
A
L
G
--
G
A
--
P
--
Q
R
A
D
------
A
--
A
A
C
A
V
E
L
I
H
A
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
T
H
R
A
F
D
E
A
T
A
I
L
A
A
D
G
L
Q
A
L
A
F
E
-
V
L
A
D
--
T
R
R
N
P
---
Q
E
H
A
---
V
C
L
------
E
M
L
T
R
--
L
A
R
A
A
G
S
A
G
M
V
G
G
Q
A
I
D
L
G
-
S
----
V
------
A
L
D
Q
A
A
L
E
---
V
M
H
R
H
K
T
G
A
L
I
E
A
S
V
R
L
G
A
L
A
S
-
G
R
A
E
P
-
A
S
L
A
A
L
E
R
Y
A
E
A
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
E
------------------
P
T
Y
P
A
L
L
G
L
E
A
A
K
G
----------------------------------
Y
A
L
E
L
R
D
L
A
L
A
A
L
D
G
F
-
P
---
P
S
-
A
---
D
P
L
R
Q
L
A
R
Y
I
-
V
E
R
R
-
21
PsiBlast_CBE
97.68
100%
-114
- C1 -
3ZOU
9
?
B:
[2-293]
M
I
A
-
A
Y
Q
A
R
C
Q
A
R
V
D
A
A
L
D
A
L
F
--
V
A
P
R
-
E
-
E
L
Q
R
L
Y
E
A
M
R
Y
S
V
M
N
G
G
K
R
V
R
P
L
L
A
Y
A
A
C
E
A
L
G
--
G
A
--
P
--
Q
R
A
D
------
A
--
A
A
C
A
V
E
L
I
H
A
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
T
H
R
A
F
D
E
A
T
A
I
L
A
A
D
G
L
Q
A
L
A
F
E
-
V
L
A
D
--
T
R
R
N
P
---
Q
E
H
A
---
V
C
L
------
E
M
L
T
R
--
L
A
R
A
A
G
S
A
G
M
V
G
G
Q
A
I
D
L
G
-
S
----
V
------
A
L
D
Q
A
A
L
E
---
V
M
H
R
H
K
T
G
A
L
I
E
A
S
V
R
L
G
A
L
A
S
-
G
R
A
E
P
-
A
S
L
A
A
L
E
R
Y
A
E
A
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
E
------------------
P
T
Y
P
A
L
L
G
L
E
A
A
K
G
----------------------------------
Y
A
L
E
L
R
D
L
A
L
A
A
L
D
G
F
-
P
---
P
S
-
A
---
D
P
L
R
Q
L
A
R
Y
I
-
V
E
---
22
PsiBlast_CBE
96.24
100%
-112
- C1 -
3ZMB
2
?
B:
[2-292]
M
I
A
-
A
Y
Q
A
R
C
Q
A
R
V
D
A
A
L
D
A
L
F
--
V
A
P
R
-
E
-
E
L
Q
R
L
Y
E
A
M
R
Y
S
V
M
N
G
G
K
R
V
R
P
L
L
A
Y
A
A
C
E
A
L
G
--
G
A
--
P
--
Q
R
A
D
------
A
--
A
A
C
A
V
E
L
I
H
A
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
T
H
R
A
F
D
E
A
T
A
I
L
A
A
D
G
L
Q
A
L
A
F
E
-
V
L
A
D
--
T
R
R
N
P
---
Q
E
H
A
---
V
C
L
------
E
M
L
T
R
--
L
A
R
A
A
G
S
A
G
M
V
G
G
Q
A
I
D
L
G
-
S
----
V
-
G
---
V
A
L
D
Q
A
A
L
E
---
V
M
H
R
H
K
T
G
A
L
I
E
A
S
V
R
L
G
A
L
A
S
-
G
R
A
E
P
-
A
S
L
A
A
L
E
R
Y
A
E
A
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
E
------------------
P
T
Y
P
A
L
L
G
L
E
A
A
K
G
----------------------------------
Y
A
L
E
L
R
D
L
A
L
A
A
L
D
G
F
-
P
---
P
S
-
A
---
D
P
L
R
Q
L
A
R
Y
I
-
V
----
85
HHSearch
91.12
77%
-103
- C1 -
3LSN
3
?
A:
[4-293]
--
T
-
A
Y
Q
A
S
S
Q
A
R
V
D
A
A
M
H
T
L
F
--
T
A
P
S
-
P
-
E
L
A
R
L
Y
E
A
M
R
Y
S
V
M
N
G
G
K
R
V
R
P
L
L
A
Y
A
A
C
E
A
L
G
--
G
K
--
P
--
E
Q
A
N
------
G
--
A
A
C
A
V
E
L
I
H
A
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
T
H
K
A
F
D
E
A
C
A
I
L
A
G
D
G
L
Q
S
L
A
F
S
-
A
L
L
D
--
P
A
L
S
D
---
A
S
A
E
---
I
R
L
------
R
M
V
T
T
--
L
A
Q
A
A
G
P
A
G
M
V
G
G
Q
A
I
D
L
G
-
S
----
V
-
G
---
L
K
L
D
Q
Q
A
L
E
---
Y
M
H
R
H
K
T
G
A
L
I
E
A
S
V
I
L
G
A
L
A
S
-
G
R
A
E
K
-
G
E
L
K
A
L
Q
T
Y
A
Q
A
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
E
S
D
T
A
T
L
------------
P
T
Y
P
A
L
L
G
L
A
A
A
K
E
----------------------------------
Y
A
L
E
L
R
D
Q
A
L
H
A
L
R
P
F
-
D
---
A
A
-
A
---
E
P
L
R
E
L
A
R
Y
I
-
V
E
---
3
PsiBlast_PDB
89.90
74%
-104
- C1 -
3LSN
3
?
A:
[3-293]
-
L
T
-
A
Y
Q
A
S
S
Q
A
R
V
D
A
A
M
H
T
L
F
--
T
A
P
S
-
P
-
E
L
A
R
L
Y
E
A
M
R
Y
S
V
M
N
G
G
K
R
V
R
P
L
L
A
Y
A
A
C
E
A
L
G
--
G
K
--
P
--
E
Q
A
N
------
G
--
A
A
C
A
V
E
L
I
H
A
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
T
H
K
A
F
D
E
A
C
A
I
L
A
G
D
G
L
Q
S
L
A
F
S
-
A
L
L
D
--
P
A
L
S
D
---
A
S
A
E
---
I
R
L
------
R
M
V
T
T
--
L
A
Q
A
A
G
P
A
G
M
V
G
G
Q
A
I
D
L
G
-
S
----
V
-
G
---
L
K
L
D
Q
Q
A
L
E
---
Y
M
H
R
H
K
T
G
A
L
I
E
A
S
V
I
L
G
A
L
A
S
-
G
R
A
E
K
-
G
E
L
K
A
L
Q
T
Y
A
Q
A
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
E
S
D
T
A
T
L
------------
P
T
Y
P
A
L
L
G
L
A
A
A
K
E
----------------------------------
Y
A
L
E
L
R
D
Q
A
L
H
A
L
R
P
F
-
D
---
A
A
-
A
---
E
P
L
R
E
L
A
R
Y
I
-
V
E
---
84
HHSearch
81.37
59%
-101
- C1 -
3TS7
2
?
A:
[9-301]
-
L
S
-
D
F
M
R
S
S
Q
E
R
V
E
R
A
L
D
A
R
L
---
P
A
A
D
R
-
M
P
E
R
L
H
Q
A
M
R
Y
S
V
L
G
G
G
K
R
M
R
P
L
L
T
Y
A
T
G
Q
T
I
G
--
V
A
--
A
--
D
L
L
D
------
G
--
P
A
C
A
V
E
F
I
H
V
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
C
H
K
A
Y
D
E
A
T
A
I
L
A
G
D
G
L
Q
A
L
A
F
H
-
V
L
A
Q
--
D
P
S
I
A
---
V
P
A
E
---
N
R
I
------
A
M
I
E
T
--
L
A
K
A
S
G
P
A
G
M
V
G
G
Q
A
I
D
L
A
-
S
----
V
-
G
---
K
K
L
D
L
P
G
L
E
---
N
M
H
I
R
K
T
G
A
L
I
R
A
S
V
R
L
A
C
L
A
R
P
G
L
P
-
A
-
E
Q
F
D
R
L
D
H
Y
A
K
C
I
G
L
A
F
Q
I
Q
D
D
I
L
D
E
E
S
D
---------------
K
P
N
Y
P
A
L
L
G
L
S
G
A
K
E
----------------------------------
K
A
E
E
M
H
E
A
A
L
E
S
L
A
G
F
-
G
---
P
E
-
A
---
D
L
L
R
E
L
A
R
F
I
-
I
Q
R
Q
-
23
PsiBlast_CBE
80.73
58%
-98
- C1 -
3TS7
3
?
B:
[9-302]
-
L
S
-
D
F
M
R
S
S
Q
E
R
V
E
R
A
L
D
A
R
L
--
P
A
A
D
-
R
-
M
P
E
R
L
H
Q
A
M
R
Y
S
V
L
G
G
G
K
R
M
R
P
L
L
T
Y
A
T
G
Q
T
I
G
--
V
A
--
A
--
D
L
L
D
------
G
--
P
A
C
A
V
E
F
I
H
V
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
C
H
K
A
Y
D
E
A
T
A
I
L
A
G
D
G
L
Q
A
L
A
F
H
-
V
L
A
Q
DP
S
I
A
V
P
---
A
E
N
R
---
I
A
--------
M
I
E
T
--
L
A
K
A
S
G
P
A
G
M
V
G
G
Q
A
I
D
L
A
-
S
----
V
-
G
---
K
K
L
D
L
P
G
L
E
---
N
M
H
I
R
K
T
G
A
L
I
R
A
S
V
R
L
A
C
L
A
R
-
P
G
L
P
A
-
E
Q
F
D
R
L
D
H
Y
A
K
C
I
G
L
A
F
Q
I
Q
D
D
I
L
D
E
E
S
D
T
Q
T
L
-----------
K
P
N
Y
P
A
L
L
G
L
S
G
A
K
E
----------------------------------
K
A
E
E
M
H
E
A
A
L
E
S
L
A
G
F
-
G
---
P
E
-
A
---
D
L
L
R
E
L
A
R
F
I
-
I
Q
R
Q
S
4
PsiBlast_PDB
79.65
58%
-101
- C1 -
3TS7
2
?
A:
[9-302]
-
L
S
-
D
F
M
R
S
S
Q
E
R
V
E
R
A
L
D
A
R
L
--
P
A
A
D
-
R
-
M
P
E
R
L
H
Q
A
M
R
Y
S
V
L
G
G
G
K
R
M
R
P
L
L
T
Y
A
T
G
Q
T
I
G
--
V
A
--
A
--
D
L
L
D
------
G
--
P
A
C
A
V
E
F
I
H
V
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
C
H
K
A
Y
D
E
A
T
A
I
L
A
G
D
G
L
Q
A
L
A
F
H
-
V
L
A
Q
DP
S
I
A
V
P
---
A
E
N
R
---
I
A
--------
M
I
E
T
--
L
A
K
A
S
G
P
A
G
M
V
G
G
Q
A
I
D
L
A
-
S
----
V
-
G
---
K
K
L
D
L
P
G
L
E
---
N
M
H
I
R
K
T
G
A
L
I
R
A
S
V
R
L
A
C
L
A
R
-
P
G
L
P
A
-
E
Q
F
D
R
L
D
H
Y
A
K
C
I
G
L
A
F
Q
I
Q
D
D
I
L
D
E
E
S
D
---------------
K
P
N
Y
P
A
L
L
G
L
S
G
A
K
E
----------------------------------
K
A
E
E
M
H
E
A
A
L
E
S
L
A
G
F
-
G
---
P
E
-
A
---
D
L
L
R
E
L
A
R
F
I
-
I
Q
R
Q
S
10
PsiBlast_PDB
77.52
49%
-100
- C1 -
3KRO
4
?
A:
[7-295]
-----
Y
M
L
R
K
A
K
S
V
N
K
A
L
E
A
A
---
V
Q
M
K
-
E
-
P
L
-
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
--
G
D
--
E
--
S
T
A
M
------
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
--
T
K
G
A
P
---
P
E
R
I
---
V
--------
R
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
-
S
----
E
-
G
MAE
V
G
L
D
H
--
L
E
---
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
E
--
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
----------------------------------
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
---
P
H
R
A
---
A
P
L
I
A
L
A
N
Y
I
-
A
Y
R
D
N
41
PsiBlast_CBE
77.35
43%
-95
- C1 -
3PDE
4
?
B:
[8-299]
-
L
I
-
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
--
L
A
D
S
-
Q
-
D
A
Q
-
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
Q
S
L
G
VT
F
V
--
P
--
E
R
H
W
------
R
--
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
-
W
L
T
A
--
T
D
L
P
A
---
T
M
Q
A
---
A
L
V
------
Q
---
A
--
L
A
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
I
Q
-
S
----
E
-
H
---
V
N
L
P
L
S
Q
L
R
---
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
-
L
I
L
-
G
Q
A
P
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
-----------
D
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
----------------------------------
A
L
I
D
T
I
H
S
G
Q
A
A
L
Q
G
L
-
P
---
T
S
-
T
QR-
D
D
L
A
A
F
F
S
Y
F
D
T
E
R
--
45
PsiBlast_CBE
77.15
43%
-90
- C1 -
3M9U
6
?
A:
[8-301]
-
L
I
-
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
--
L
A
D
S
-
Q
-
D
A
Q
-
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
Q
S
L
G
V
T
F
V
--
P
--
E
R
H
W
------
R
--
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
-
W
L
T
A
--
T
D
L
P
A
---
T
M
Q
A
---
A
L
V
------
Q
---
A
--
L
A
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
I
Q
-
S
----
E
-
H
---
V
N
L
P
L
S
Q
L
R
---
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
-
L
I
L
-
G
Q
A
P
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
------------
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
----------------------------------
A
L
I
D
T
I
H
S
G
Q
A
A
L
Q
G
L
-
P
---
T
S
-
T
Q
R
-
D
D
L
A
A
F
F
S
Y
F
D
T
E
R
V
N
9
PsiBlast_PDB
77.04
49%
-100
- C1 -
3KRF
4
?
A:
[7-295]
-----
Y
M
L
R
K
A
K
S
V
N
K
A
L
E
A
A
---
V
Q
M
K
-
E
-
P
L
-
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
--
G
D
--
E
--
S
T
A
M
------
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
--
T
K
G
A
P
---
P
E
R
I
---
V
--------
R
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
-
S
----
E
-
G
MAE
V
G
L
D
H
--
L
E
---
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
E
--
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
----------------------------------
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
---
P
H
R
A
---
A
P
L
I
A
L
A
N
Y
I
-
A
Y
R
D
N
43
PsiBlast_CBE
76.95
43%
-92
- C1 -
3M9U
6
?
C:
[8-299]
-
L
I
-
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
--
L
A
D
S
-
Q
-
D
A
Q
-
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
Q
S
L
G
VT
F
V
--
P
--
E
R
H
W
------
R
--
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
-
W
L
T
A
--
T
D
L
P
A
---
T
M
Q
A
---
A
L
V
------
Q
---
A
--
L
A
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
I
Q
-
S
----
E
-
H
---
V
N
L
P
L
S
Q
L
R
---
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
-
L
I
L
-
G
Q
A
P
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
--------------
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
----------------------------------
A
L
I
D
T
I
H
S
G
Q
A
A
L
Q
G
L
-
P
---
T
S
-
T
QR-
D
D
L
A
A
F
F
S
Y
F
D
T
E
R
--
8
PsiBlast_PDB
76.94
49%
-100
- C1 -
3KRC
1
?
A:
[7-295]
-----
Y
M
L
R
K
A
K
S
V
N
K
A
L
E
A
A
---
V
Q
M
K
-
E
-
P
L
-
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
--
G
D
--
E
--
S
T
A
M
------
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
--
T
K
G
A
P
---
P
E
R
I
---
V
--------
R
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
-
S
----
E
-
G
MAE
V
G
L
D
H
--
L
E
---
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
E
--
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
----------------------------------
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
---
P
H
R
A
---
A
P
L
I
A
L
A
N
Y
I
-
A
Y
R
D
N
42
PsiBlast_CBE
76.81
43%
-91
- C1 -
3PDE
5
?
A:
[8-301]
-
L
I
-
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
--
L
A
D
S
-
Q
-
D
A
Q
-
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
Q
S
L
G
V
T
F
V
--
P
--
E
R
H
W
------
R
--
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
-
W
L
T
A
--
T
D
L
P
A
---
T
M
Q
A
---
A
L
V
------
Q
---
A
--
L
A
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
I
Q
-
S
----
E
-
H
---
V
N
L
P
L
S
Q
L
R
---
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
-
L
I
L
-
G
Q
A
P
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
-----------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
----------------------------------
A
L
I
D
T
I
H
S
G
Q
A
A
L
Q
G
L
-
P
---
T
S
-
T
Q
R
-
D
D
L
A
A
F
F
S
Y
F
D
T
E
R
V
N
44
PsiBlast_CBE
76.71
43%
-94
- C1 -
3M9U
3
?
B:
[8-299]
-
L
I
-
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
--
L
A
D
S
-
Q
-
D
A
Q
-
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
Q
S
L
G
VT
F
V
--
P
--
E
R
H
W
------
R
--
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
-
W
L
T
A
--
T
D
L
P
A
---
T
M
Q
A
---
A
L
V
------
Q
---
A
--
L
A
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
I
Q
-
S
----
E
-
H
---
V
N
L
P
L
S
Q
L
R
---
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
-
L
I
L
-
G
Q
A
P
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
-------------
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
----------------------------------
A
L
I
D
T
I
H
S
G
Q
A
A
L
Q
G
L
-
P
---
T
S
-
T
QR-
D
D
L
A
A
F
F
S
Y
F
D
T
E
R
--
5
PsiBlast_PDB
76.66
51%
-107
- C1 -
4F62
2
?
A:
[8-292]
-----
F
S
T
Y
T
Q
S
R
V
D
Q
Y
L
E
Q
Q
L
SD
Y
A
P
A
-
N
-
Q
L
---
H
N
A
M
R
Y
S
L
F
-
G
G
K
R
I
R
P
M
L
T
Y
A
S
A
Q
L
V
G
--
D
I
--
S
--
S
L
T
D
------
A
--
S
A
A
A
L
E
S
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
N
-------
P
T
C
H
I
Q
F
D
E
A
T
A
I
L
A
G
D
A
L
Q
T
F
A
F
E
-
L
L
S
N
P-
T
S
A
Q
P
---
E
------
L
A
I
------
K
L
I
Q
E
--
L
V
V
A
S
G
R
N
G
M
I
T
G
Q
M
I
D
L
S
-
S
----
E
-
N
---
K
N
I
S
L
A
E
L
E
---
Q
M
H
V
H
K
T
G
A
L
I
K
A
S
V
R
M
G
A
L
S
T
-
G
Q
V
K
P
-
E
Q
L
A
K
L
D
A
Y
A
H
A
I
G
L
A
F
Q
V
Q
D
D
I
I
D
L
T
----------------
N
K
A
T
Y
P
K
L
L
G
L
D
G
A
K
A
----------------------------------
L
V
V
R
L
H
E
Q
A
I
A
Q
I
S
E
F
-
G
---
D
K
-
S
---
Q
P
L
T
D
L
A
N
Y
I
-
I
D
---
40
PsiBlast_CBE
76.51
43%
-92
- C1 -
3PDE
5
?
C:
[8-299]
-
L
I
-
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
--
L
A
D
S
-
Q
-
D
A
Q
-
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
Q
S
L
G
VT
F
V
--
P
--
E
R
H
W
------
R
--
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
-
W
L
T
A
--
T
D
L
P
A
---
T
M
Q
A
---
A
L
V
------
Q
---
A
--
L
A
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
I
Q
-
S
----
E
-
H
---
V
N
L
P
L
S
Q
L
R
---
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
-
L
I
L
-
G
Q
A
P
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
----------------
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
----------------------------------
A
L
I
D
T
I
H
S
G
Q
A
A
L
Q
G
L
-
P
---
T
S
-
T
QR-
D
D
L
A
A
F
F
S
Y
F
D
T
E
R
--
12
PsiBlast_PDB
76.24
49%
-101
- C1 -
3OAB
4
?
A:
[7-295]
-----
Y
M
L
R
K
A
K
S
V
N
K
A
L
E
A
A
---
V
Q
M
K
-
E
-
P
L
-
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
--
G
D
--
E
--
S
T
A
M
------
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
--
T
K
G
A
P
---
P
E
R
I
---
V
--------
R
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
-
S
----
E
-
G
MAE
V
G
L
D
H
--
L
E
---
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
E
--
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
----------------------------------
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
---
P
H
R
A
---
A
P
L
I
A
L
A
N
Y
I
-
A
Y
R
D
N
13
PsiBlast_PDB
76.06
49%
-99
- C1 -
3OAC
-
?
A:
[7-295]
-----
Y
M
L
R
K
A
K
S
V
N
K
A
L
E
A
A
---
V
Q
M
K
-
E
-
P
L
-
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
--
G
D
--
E
--
S
T
A
M
------
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
--
T
K
G
A
P
---
P
E
R
I
---
V
--------
R
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
-
S
----
E
-
G
MAE
V
G
L
D
H
--
L
E
---
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
E
--
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
----------------------------------
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
---
P
H
R
A
---
A
P
L
I
A
L
A
N
Y
I
-
A
Y
R
D
N
11
PsiBlast_PDB
75.80
49%
-100
- C1 -
3KRP
3
?
A:
[7-295]
-----
Y
M
L
R
K
A
K
S
V
N
K
A
L
E
A
A
---
V
Q
M
K
-
E
-
P
L
-
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
--
G
D
--
E
--
S
T
A
M
------
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
--
T
K
G
A
P
---
P
E
R
I
---
V
--------
R
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
-
S
----
E
-
G
MAE
V
G
L
D
H
--
L
E
---
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
E
--
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
----------------------------------
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
---
P
H
R
A
---
A
P
L
I
A
L
A
N
Y
I
-
A
Y
R
D
N
39
PsiBlast_CBE
75.79
43%
-91
* C1 *
3PDE
4
?
D:
[8-301]
-
L
I
-
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
--
L
A
D
S
-
Q
-
D
A
Q
-
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
Q
S
L
G
VT
F
V
--
P
--
E
R
H
W
------
R
--
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
-
W
L
T
A
--
T
D
L
P
A
---
T
M
Q
A
---
A
L
V
------
Q
---
A
--
L
A
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
I
Q
-
S
----
E
-
H
---
V
N
L
P
L
S
Q
L
R
---
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
-
L
I
L
-
G
Q
A
P
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
P
A
---------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
----------------------------------
A
L
I
D
T
I
H
S
G
Q
A
A
L
Q
G
L
-
P
---
T
S
-
T
QR-
D
D
L
A
A
F
F
S
Y
F
D
T
E
R
V
N
89
HHSearch
75.31
52%
-77
- C1 -
1RQJ
5
ISPA_ECOLI
A:
[4-299]
--
P
-
Q
Q
L
E
A
C
V
K
Q
A
N
Q
A
L
S
R
F
I
---
A
P
L
P
F
-
Q
N
T
P
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
H
M
F
G
--
V
S
--
T
--
N
T
L
D
------
A
--
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
-
I
L
S
D
--
A
D
M
P
E
---
V
S
D
R
---
D
R
I
------
S
M
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
L
D
-
A
----
E
-
G
---
K
H
V
P
L
D
A
L
E
---
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
-
G
D
K
-
G
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
K
----------------------------------
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
-
A
E
Q
S
L
D
-
T
---
S
A
L
E
A
L
A
D
Y
I
-
I
Q
R
N
K
30
PsiBlast_CBE
75.20
49%
-98
- C1 -
3KRC
1
?
D:
[7-295]
-----
Y
M
L
R
K
A
K
S
V
N
K
A
L
E
A
A
---
V
Q
M
K
-
E
-
P
L
-
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
--
G
D
--
E
--
S
T
A
M
------
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
--
T
K
G
A
P
---
P
E
R
I
---
V
--------
R
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
-
S
----
E
-
G
MAE
V
G
L
D
H
--
L
E
---
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
E
--
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
------------------
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
----------------------------------
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
---
P
H
R
A
---
A
P
L
I
A
L
A
N
Y
I
-
A
Y
R
D
N
34
PsiBlast_CBE
75.03
51%
-78
- C1 -
1RQI
5
ISPA_ECOLI
B:
[11-300]
---------
C
V
K
Q
A
N
Q
A
L
-
S
R
F
--
I
A
P
L
-
P
F
Q
N
T
P
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
H
M
F
G
--
V
S
--
T
--
N
T
L
D
------
A
--
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
-
I
L
S
D
--
A
D
M
P
E
---
V
S
D
R
---
D
R
I
------
S
M
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
L
D
-
A
----
E
-
G
---
K
H
V
P
L
D
A
L
E
---
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
-
G
D
K
G
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
K
----------------------------------
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
-
A
---
E
Q
-
S
LDT
S
A
L
E
A
L
A
D
Y
I
-
I
Q
R
N
K
26
PsiBlast_CBE
74.86
49%
-82
- C1 -
3OAB
4
?
D:
[7-295]
-----
Y
M
L
R
K
A
K
S
V
N
K
A
L
E
A
A
---
V
Q
M
K
-
E
-
P
L
-
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
--
G
D
--
E
--
S
T
A
M
------
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
--
T
K
G
A
P
---
P
E
R
I
---
V
--------
R
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
-
S
----
E
-
G
MAE
V
G
L
D
H
--
L
E
---
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
E
--
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
----------------------------------
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
---
P
H
R
A
---
A
P
L
I
A
L
A
N
Y
I
-
A
Y
R
D
N
25
PsiBlast_CBE
74.73
49%
-81
- C1 -
3OAC
4
?
D:
[7-295]
-----
Y
M
L
R
K
A
K
S
V
N
K
A
L
E
A
A
---
V
Q
M
K
-
E
-
P
L
-
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
--
G
D
--
E
--
S
T
A
M
------
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
--
T
K
G
A
P
---
P
E
R
I
---
V
--------
R
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
-
S
----
E
-
G
MAE
V
G
L
D
H
--
L
E
---
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
E
--
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
----------------------------------
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
---
P
H
R
A
---
A
P
L
I
A
L
A
N
Y
I
-
A
Y
R
D
N
94
HHSearch
74.71
45%
-100
- C1 -
2J1P
2
GGPPS_SINAL
A:
[15-292]
----
S
Y
I
I
R
K
A
D
S
V
N
K
A
L
D
S
A
V
--
P
-
L
--
R
-
E
P
L
K
I
H
E
A
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
V
L
C
I
A
A
C
E
L
V
G
--
G
E
--
E
--
S
L
A
M
------
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
I
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
K
V
Y
G
E
D
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
-
H
L
A
S
--
A
T
S
S
E
---
V
S
P
A
---
R
V
V
------
R
A
V
G
E
--
L
A
K
A
I
G
T
E
G
L
V
A
G
Q
V
V
D
I
S
--------
L
DL-
N
N
V
G
L
E
H
L
K
---
F
I
H
L
H
K
T
A
A
L
L
E
A
S
A
V
L
G
G
I
I
G
-
G
G
S
-
D
-
E
E
I
E
R
L
R
K
F
A
R
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
L
T
Y
P
K
L
M
G
L
E
K
S
R
E
----------------------------------
F
A
E
K
L
N
T
E
A
R
D
Q
L
L
G
F
-
D
S--
D
K
-
V
---
A
P
L
L
A
L
A
N
Y
I
-
A
N
R
Q
-
27
PsiBlast_CBE
74.66
49%
-97
- C1 -
3KRP
3
?
D:
[7-295]
-----
Y
M
L
R
K
A
K
S
V
N
K
A
L
E
A
A
---
V
Q
M
K
-
E
-
P
L
-
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
--
G
D
--
E
--
S
T
A
M
------
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
--
T
K
G
A
P
---
P
E
R
I
---
V
--------
R
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
-
S
----
E
-
G
MAE
V
G
L
D
H
--
L
E
---
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
E
--
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
-----------
T
Y
P
K
L
I
G
V
E
K
S
K
E
----------------------------------
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
---
P
H
R
A
---
A
P
L
I
A
L
A
N
Y
I
-
A
Y
R
D
N
29
PsiBlast_CBE
74.50
49%
-83
- C1 -
3KRF
4
?
D:
[7-295]
-----
Y
M
L
R
K
A
K
S
V
N
K
A
L
E
A
A
---
V
Q
M
K
-
E
-
P
L
-
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
--
G
D
--
E
--
S
T
A
M
------
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
--
T
K
G
A
P
---
P
E
R
I
---
V
--------
R
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
-
S
----
E
-
G
MAE
V
G
L
D
H
--
L
E
---
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
E
--
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
----------------------------------
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
---
P
H
R
A
---
A
P
L
I
A
L
A
N
Y
I
-
A
Y
R
D
N
33
PsiBlast_CBE
74.31
51%
-76
- C1 -
1RQJ
5
ISPA_ECOLI
B:
[10-299]
---------
C
V
K
Q
A
N
Q
A
L
-
S
R
F
--
I
A
P
L
-
P
F
Q
N
T
P
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
H
M
F
G
--
V
S
--
T
--
N
T
L
D
------
A
--
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
-
I
L
S
D
--
A
D
M
P
E
---
V
S
D
R
---
D
R
I
------
S
M
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
L
D
-
A
----
E
-
G
---
K
H
V
P
L
D
A
L
E
---
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
-
G
D
K
G
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
K
----------------------------------
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
-
A
---
E
Q
-
S
LDT
S
A
L
E
A
L
A
D
Y
I
-
I
Q
R
N
K
28
PsiBlast_CBE
73.75
49%
-83
- C1 -
3KRO
4
?
D:
[7-295]
-----
Y
M
L
R
K
A
K
S
V
N
K
A
L
E
A
A
---
V
Q
M
K
-
E
-
P
L
-
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
--
G
D
--
E
--
S
T
A
M
------
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
--
T
K
G
A
P
---
P
E
R
I
---
V
--------
R
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
-
S
----
E
-
G
MAE
V
G
L
D
H
--
L
E
---
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
E
--
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
----------------------------------
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
---
P
H
R
A
---
A
P
L
I
A
L
A
N
Y
I
-
A
Y
R
D
N
18
PsiBlast_PDB
73.26
42%
-101
- C1 -
2J1P
2
GGPPS_SINAL
A:
[15-293]
----
S
Y
I
I
R
K
A
D
S
V
N
K
A
L
D
S
----
A
V
P
L
-
R
-
E
P
L
K
I
H
E
A
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
V
L
C
I
A
A
C
E
L
V
G
--
G
E
--
E
--
S
L
A
M
------
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
I
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
K
V
Y
G
E
D
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
-
H
L
A
S
--
A
T
S
S
E
---
V
S
P
A
---
R
V
V
------
R
A
V
G
E
--
L
A
K
A
I
G
T
E
G
L
V
A
G
Q
V
V
D
I
S
------------
L
D
L
N
N
V
G
L
E
H
L
K
F
I
H
L
H
K
T
A
A
L
L
E
A
S
A
V
L
G
G
I
I
G
-
G
G
S
D
E
--
E
I
E
R
L
R
K
F
A
R
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
L
T
Y
P
K
L
M
G
L
E
K
S
R
E
----------------------------------
F
A
E
K
L
N
T
E
A
R
D
Q
L
L
G
F
D
S
---
D
K
-
V
---
A
P
L
L
A
L
A
N
Y
I
-
A
N
R
Q
N
16
PsiBlast_PDB
72.36
51%
-77
- C1 -
1RQI
6
ISPA_ECOLI
A:
[11-300]
---------
C
V
K
Q
A
N
Q
A
L
-
S
R
F
--
I
A
P
L
-
P
F
Q
N
T
P
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
H
M
F
G
--
V
S
--
T
--
N
T
L
D
------
A
--
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
-
I
L
S
D
--
A
D
M
P
E
---
V
S
D
R
---
D
R
I
------
S
M
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
L
D
-
A
----
E
-
G
---
K
H
V
P
L
D
A
L
E
---
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
-
G
D
K
G
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
K
----------------------------------
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
-
A
---
E
Q
-
S
LDT
S
A
L
E
A
L
A
D
Y
I
-
I
Q
R
N
K
15
PsiBlast_PDB
72.35
51%
-77
- C1 -
1RQJ
5
ISPA_ECOLI
A:
[10-299]
---------
C
V
K
Q
A
N
Q
A
L
-
S
R
F
--
I
A
P
L
-
P
F
Q
N
T
P
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
H
M
F
G
--
V
S
--
T
--
N
T
L
D
------
A
--
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
-
I
L
S
D
--
A
D
M
P
E
---
V
S
D
R
---
D
R
I
------
S
M
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
L
D
-
A
----
E
-
G
---
K
H
V
P
L
D
A
L
E
---
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
-
G
D
K
G
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
K
----------------------------------
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
-
A
---
E
Q
-
S
LDT
S
A
L
E
A
L
A
D
Y
I
-
I
Q
R
N
K
86
HHSearch
72.31
42%
-92
- C1 -
3PDE
5
?
A:
[9-299]
--
I
-
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
--
L
A
D
--
S
-
Q
D
A
Q
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
Q
S
L
G
--
V
T
F
V
P
--
E
R
H
W
------
R
--
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
-
W
L
T
A
--
T
D
L
P
------
A
T
---
M
Q
A
------
A
L
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
I
Q
-
S
----
E
-
H
---
V
N
L
P
L
S
Q
L
R
---
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
L
I
L
G
-
Q
A
P
-
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
-----------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
----------------------------------
A
L
I
D
T
I
H
S
G
Q
A
A
L
Q
G
L
-
P
TS-
T
Q
-
R
---
D
D
L
A
A
F
F
S
Y
F
-
D
T
E
R
-
24
PsiBlast_CBE
71.58
51%
-110
- C1 -
4F62
2
?
B:
[8-292]
-----
F
S
T
Y
T
Q
S
R
V
D
Q
Y
L
E
Q
Q
L
SD
Y
A
P
A
-
N
-
Q
L
---
H
N
A
M
R
Y
S
L
F
-
G
G
K
R
I
R
P
M
L
T
Y
A
S
A
Q
L
V
G
--
D
I
--
S
--
S
L
T
D
------
A
--
S
A
A
A
L
E
S
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
---------------
F
D
E
A
T
A
I
L
A
G
D
A
L
Q
T
F
A
F
E
-
L
L
S
N
P-
T
S
A
Q
P
---
E
------
L
A
I
------
K
L
I
Q
E
--
L
V
V
A
S
G
R
N
G
M
I
T
G
Q
M
I
D
L
S
-
S
----
E
------
N
I
S
L
A
E
L
E
---
Q
M
H
V
H
K
T
G
A
L
I
K
A
S
V
R
M
G
A
L
S
T
-
G
Q
V
K
P
-
E
Q
L
A
K
L
D
A
Y
A
H
A
I
G
L
A
F
Q
V
Q
D
D
I
I
D
L
------------------
K
A
T
Y
P
K
L
L
G
L
D
G
A
K
A
----------------------------------
L
V
V
R
L
H
E
Q
A
I
A
Q
I
S
E
F
-
G
---
D
K
-
S
---
Q
P
L
T
D
L
A
N
Y
I
-
I
D
---
37
PsiBlast_CBE
62.54
43%
-80
- C1 -
4LLT
5
?
A:
[35-311]
---------
V
Q
A
H
F
D
K
V
L
A
A
F
E
--
P
L
P
--------
I
V
E
A
M
A
H
A
T
-
S
G
G
K
R
L
R
G
F
L
V
L
E
T
A
R
L
H
D
--
I
A
--
A
--
G
E
A
I
------
W
--
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
-
L
V
T
------
H
P
---
G
A
S
A
S
A
E
V
R
A
------
D
L
A
L
S
--
L
A
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
I
A
-
A
E
T
A
R
A
-
P
---
L
S
L
D
E
--
I
T
---
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
-----
R
L
A
Q
-
A
D
T
A
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
----------------------------------
R
A
M
S
L
I
D
E
A
C
D
S
L
A
T
Y
-
G
---
A
K
-
A
---
D
T
L
R
E
T
A
R
F
V
-
V
R
R
T
H
38
PsiBlast_CBE
61.32
43%
-81
- C1 -
4LLS
6
?
B:
[35-311]
---------
V
Q
A
H
F
D
K
V
L
A
A
F
E
--
P
L
P
--------
I
V
E
A
M
A
H
A
T
-
S
G
G
K
R
L
R
G
F
L
V
L
E
T
A
R
L
H
D
--
I
A
--
A
--
G
E
A
I
------
W
--
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
-
L
V
T
------
H
P
---
G
A
S
A
S
A
E
V
R
A
------
D
L
A
L
S
--
L
A
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
I
A
-
A
E
T
AR
A
-
P
---
L
S
L
D
E
--
I
T
---
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
-----
R
L
A
Q
-
A
D
T
A
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
----------------------------------
R
A
M
S
L
I
D
E
A
C
D
S
L
A
T
Y
-
G
---
A
K
-
A
---
D
T
L
R
E
T
A
R
F
V
-
V
R
R
T
H
36
PsiBlast_CBE
60.63
43%
-80
- C1 -
4LLT
5
?
B:
[35-311]
---------
V
Q
A
H
F
D
K
V
L
A
A
F
E
--
P
L
P
--------
I
V
E
A
M
A
H
A
T
-
S
G
G
K
R
L
R
G
F
L
V
L
E
T
A
R
L
H
D
--
I
A
--
A
--
G
E
A
I
------
W
--
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
-
L
V
T
------
H
P
---
G
A
S
A
S
A
E
V
R
A
------
D
L
A
L
S
--
L
A
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
I
A
-
A
E
TAR
A
-
P
---
L
S
L
D
E
--
I
T
---
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
-----
R
L
A
Q
-
A
D
T
A
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
----------------------------------
R
A
M
S
L
I
D
E
A
C
D
S
L
A
T
Y
-
G
---
A
K
-
A
---
D
T
L
R
E
T
A
R
F
V
-
V
R
R
T
H
101
HHSearch
60.48
34%
-106
- C1 -
3OYR
1
?
A:
[31-343]
------
A
E
A
D
M
A
G
V
N
R
L
I
T
D
R
M
---
Q
---
S
-
D
V
A
I
I
P
A
L
A
E
H
L
I
A
A
G
G
K
R
L
R
P
L
M
T
V
A
A
A
R
L
A
G
--
A
D
--
N
--
D
H
F
Q
------
K
--
L
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
---------
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
-
L
M
V
E
--
T
N
S
--------------
M
------
K
A
L
E
I
--
L
A
R
A
S
--
R
V
I
A
E
G
E
V
L
Q
L
M
-
R
----
S
H
D
---
L
N
L
S
Q
A
V
Y
L
---
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
-
G
V
D
-
V
-
A
K
S
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
-------------------
A
T
L
P
L
L
L
A
I
A
R
S
G
P
REA
E
F
W
E
R
A
I
GTEADF
R
R
A
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
-
P
AN-
D
W
-
R
---
E
A
L
E
E
L
A
D
F
A
-
V
S
R
--
20
PsiBlast_PDB
60.37
43%
-78
- C1 -
4LLS
6
?
A:
[35-311]
---------
V
Q
A
H
F
D
K
V
L
A
A
F
E
--
P
L
P
--------
I
V
E
A
M
A
H
A
T
-
S
G
G
K
R
L
R
G
F
L
V
L
E
T
A
R
L
H
D
--
I
A
--
A
--
G
E
A
I
------
W
--
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
-
L
V
T
------
H
P
---
G
A
S
A
S
A
E
V
R
A
------
D
L
A
L
S
--
L
A
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
I
A
-
A
E
T
A
R
A
-
P
---
L
S
L
D
E
--
I
T
---
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
-----
R
L
A
Q
-
A
D
T
A
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
----------------------------------
R
A
M
S
L
I
D
E
A
C
D
S
L
A
T
Y
-
G
---
A
K
-
A
---
D
T
L
R
E
T
A
R
F
V
-
V
R
R
T
H
98
HHSearch
54.59
32%
-81
- C1 -
3NPK
2
?
A:
[5-281]
---------
L
K
E
L
F
I
H
H
L
E
K
N
L
---
P
K
V
E
S
-
F
H
P
F
F
N
E
A
L
A
L
M
L
K
A
G
G
K
H
F
R
A
Q
L
L
L
S
V
V
Q
S
N
K
--
P
E
L-
L
--
N
Q
A
L
------
D
--
V
A
L
A
L
E
F
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
A
D
F
R
R
G
I
P
T
L
H
K
S
Y
D
E
T
T
A
I
L
V
G
D
A
L
N
T
E
A
F
L
-
V
L
S
H
--
A
H
L
K
------
D
E
---
I
K
I
------
K
L
I
K
T
L
A
F
N
A
G
L
--
N
G
M
V
I
G
Q
A
I
D
C
F
-
F
----
E
-
D
---
K
R
L
S
L
N
E
L
E
---
F
L
H
T
H
K
T
A
R
L
I
A
A
A
L
K
M
G
C
E
I
C
-
E
L
N
-
N
-
E
E
S
N
Q
I
Y
K
L
G
L
K
L
G
L
I
F
Q
I
N
D
D
I
I
D
V
T
------------------
N
S
F
V
N
L
L
G
L
E
Q
A
I
K
----------------------------------
T
K
E
N
L
L
N
E
C
E
Q
D
L
E
K
L
-
N
E
--
K
L
-
A
---
Q
M
I
Q
N
L
I
I
Q
-------
47
PsiBlast_CBE
54.31
43%
-68
- C1 -
4LFG
5
?
A:
[7-250]
------------
K
I
D
Q
T
I
H
A
F
Y
--
C
E
K
A
-
V
-
I
S
E
K
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
I
E
A
L
Q
--
I
P
--
L
--
T
E
S
H
F
-----
K
--
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
-
M
L
A
E
--
T
D
F
-
P
---
T
D
-----
V
T
V
------
D
L
V
R
S
--
L
S
S
A
S
G
T
F
G
M
V
G
G
Q
M
L
D
M
A
-
A
----
E
-
G
---
K
K
L
N
L
K
N
L
Q
---
L
I
H
R
H
K
T
G
Q
L
L
-
A
Y
P
F
W
A
A
A
R
V
-
A
Q
L
D
E
-
N
L
L
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
--------------------------------------------------------------------------------
48
PsiBlast_CBE
53.65
43%
-68
- C1 -
4LFE
5
?
B:
[7-250]
------------
K
I
D
Q
T
I
H
A
F
Y
--
C
E
K
A
-
V
-
I
S
E
K
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
I
E
A
L
Q
--
I
P
--
L
--
T
E
S
H
F
-----
K
--
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
-
M
L
A
E
--
T
D
F
-
P
---
T
D
-----
V
T
V
------
D
L
V
R
S
--
L
S
S
A
S
G
T
F
G
M
V
G
G
Q
M
L
D
M
A
-
A
----
E
-
G
---
K
K
L
N
L
K
N
L
Q
---
L
I
H
R
H
K
T
G
Q
L
L
-
A
Y
P
F
W
A
A
A
R
V
-
A
Q
L
D
E
-
N
L
L
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
--------------------------------------------------------------------------------
54
PsiBlast_CBE
53.64
39%
-72
- C1 -
3Q1O
5
?
C:
[51-297]
-------------------------------------------
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
--
G
Q
--
K
--
D
Y
S
N
QQTEYF
K
--
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
-
L
L
S
N
--
A
L
L
------
E
S
H
---
I
I
V
------
E
L
I
K
I
--
L
S
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
C
Y
-
F
----
E
-
N
---
T
P
L
N
L
E
Q
L
T
---
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
D
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
A
K
N
--
S
F
V
N
L
L
G
L
E
R
A
N
N
----------------------------------
Y
A
Q
T
L
K
T
E
V
L
N
D
L
D
A
L
-
K
---
P
--
A
---
Y
P
L
L
Q
-----------
46
PsiBlast_CBE
53.53
43%
-70
- C1 -
4LFG
5
?
B:
[7-250]
------------
K
I
D
Q
T
I
H
A
F
Y
--
C
E
K
A
-
V
-
I
S
E
K
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
I
E
A
L
Q
--
I
P
--
L
--
T
E
S
H
F
-----
K
--
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
-
M
L
A
E
--
T
D
F
-
P
---
T
D
-----
V
T
V
------
D
L
V
R
S
--
L
S
S
A
S
G
T
F
G
M
V
G
G
Q
M
L
D
M
A
-
A
----
E
-
G
---
K
K
L
N
L
K
N
L
Q
---
L
I
H
R
H
K
T
G
Q
L
L
-
A
Y
P
F
W
A
A
A
R
V
-
A
Q
L
D
E
-
N
L
L
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
--------------------------------------------------------------------------------
55
PsiBlast_CBE
53.43
39%
-72
- C1 -
3Q1O
4
?
B:
[51-297]
-------------------------------------------
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
--
G
Q
--
K
--
D
Y
S
N
Q
Q
T
E
Y
F
K
--
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
-
L
L
S
N
--
A
L
L
------
E
S
H
---
I
I
V
------
E
L
I
K
I
--
L
S
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
C
Y
-
F
----
E
-
N
---
T
P
L
N
L
E
Q
L
T
---
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
D
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
A
K
N
--
S
F
V
N
L
L
G
L
E
R
A
N
N
----------------------------------
Y
A
Q
T
L
K
T
E
V
L
N
D
L
D
A
L
-
K
---
P
--
A
---
Y
P
L
L
Q
-----------
56
PsiBlast_CBE
53.29
39%
-70
- C1 -
3Q1O
4
?
A:
[51-297]
-------------------------------------------
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
--
G
Q
--
K
--
D
Y
S
N
Q
Q
T
E
Y
F
K
--
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
-
L
L
S
N
--
A
L
L
------
E
S
H
---
I
I
V
------
E
L
I
K
I
--
L
S
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
C
Y
-
F
----
E
-
N
---
T
P
L
N
L
E
Q
L
T
---
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
D
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
A
K
N
--
S
F
V
N
L
L
G
L
E
R
A
N
N
----------------------------------
Y
A
Q
T
L
K
T
E
V
L
N
D
L
D
A
L
-
K
---
P
--
A
---
Y
P
L
L
Q
-----------
53
PsiBlast_CBE
53.00
39%
-69
- C1 -
3Q1O
3
?
D:
[51-297]
-------------------------------------------
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
--
G
Q
--
K
--
D
Y
S
N
QQTEYF
K
--
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
-
L
L
S
N
--
A
L
L
------
E
S
H
---
I
I
V
------
E
L
I
K
I
--
L
S
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
C
Y
-
F
----
E
-
N
---
T
P
L
N
L
E
Q
L
T
---
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
D
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
A
K
N
--
S
F
V
N
L
L
G
L
E
R
A
N
N
----------------------------------
Y
A
Q
T
L
K
T
E
V
L
N
D
L
D
A
L
-
K
---
P
--
A
---
Y
P
L
L
Q
-----------
63
PsiBlast_CBE
45.19
32%
-65
- C1 -
3AQC
5
HEXB_MICLU
D:
[1-241]
M
I
A
L
S
Y
K
A
F
L
N
P
Y
I
I
E
V
E
K
R
L
Y
--
E
C
I
Q
-
S
-
D
S
E
T
I
N
K
A
A
H
H
I
L
S
S
G
G
K
R
V
R
P
M
--
F
V
L
L
S
G
F
L
--
N
D
--
T
--
Q
K
D
D
------
L
IR
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
-
N
I
A
---
T
I
N
N
S
---
K
F
H
Q
---
I
F
S
------
K
T
I
L
E
--
V
C
F
G
E
F
D
------
Q
M
A
D
R
F
-
N
----
Y
-
P
---
V
S
F
-
T
A
Y
L
R
---
R
I
N
R
-
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
--
Q
L
D
E
-
Q
S
T
Y
H
I
K
Q
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
--------------------------------------------------------------------------------------
64
PsiBlast_CBE
39.62
32%
-60
- C1 -
3AQC
4
HEXB_MICLU
B:
[5-241]
----
S
Y
K
A
F
L
N
P
Y
I
I
E
V
E
K
R
L
Y
--
E
C
I
Q
-
S
-
D
S
E
T
I
N
K
A
A
H
H
I
L
S
S
G
G
K
R
V
R
P
M
--
F
V
L
L
S
G
F
L
--
N
D
--
T
--
Q
K
D
D
------
L
I
R
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
-
N
I
A
---
T
I
N
N
S
---
K
F
H
Q
---
I
F
S
------
K
T
I
L
E
--
V
C
F
G
E
F
D
------
Q
M
A
D
R
F
-
N
----
Y
-
P
---
V
S
F
-
T
A
Y
L
R
---
R
I
N
R
-
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
--
Q
L
D
E
-
Q
S
T
Y
H
I
K
Q
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
--------------------------------------------------------------------------------------
73
PsiBlast_CBE
36.43
36%
-70
- C1 -
3OYR
4
?
B:
[64-265]
----------------------------------------------
G
G
K
R
L
R
P
L
M
T
V
A
A
A
R
L
A
G
--
A
D
--
N
--
D
H
F
Q
------
K
--
L
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
G
S
Q
L
R
R
G
K
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
-
L
M
V
E
--
T
--
N
S
---
M
K
------
A
L
------
E
I
L
A
R
--
A
S
R
V
-----
I
A
E
G
E
V
L
Q
L
M
R
S
----
H
-
D
---
L
N
L
S
Q
A
V
Y
L
---
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
-
G
-
V
D
V
-
A
K
S
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
G
G
A
T
E
T
L
G
K
N
A
G
D
D
F
R
E
G
K
A
T
L
P
L
L
L
A
I
-----------------------------------------------------------------------------------
69
PsiBlast_CBE
30.47
38%
-57
- C1 -
4GP1
3
?
A:
[35-249]
-------------------------------------
E
A
V
L
Y
Q
V
K
T
G
G
K
R
L
R
P
L
L
T
L
A
A
A
E
A
V
S
--
G
Q
--
W
--
R
P
A
L
------
P
--
A
A
A
I
V
E
L
I
H
N
Y
S
L
I
Y
D
D
I
--
I
D
R
G
D
V
R
R
G
L
P
T
V
R
K
A
F
G
D
N
A
A
I
L
V
G
I
W
Y
R
E
A
I
E
E
-
A
V
L
D
--
T
P
K
P
T
L
F
A
K
E
V
A
---
E
V
I
K
A
I
D
E
G
E
R
L
D
I
--
L
F
E
A
A
G
R
S
D
P
Y
F
V
Q
A
---
R
-
W
----
R
-
E
---
V
T
L
D
D
Y
I
-----
K
M
V
S
L
K
T
G
A
L
I
A
A
A
A
K
W
G
V
L
S
V
-
S
D
D
R
G
-
L
A
E
A
A
W
N
-
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
-------
E
I
G
K
D
I
K
E
H
K
--------------------------------------------------------------------------------------------
67
PsiBlast_CBE
30.37
38%
-56
- C1 -
4GP2
5
?
B:
[35-249]
-------------------------------------
E
A
V
L
Y
Q
V
K
T
G
G
K
R
L
R
P
L
L
T
L
A
A
A
E
A
V
S
--
G
Q
--
W
--
R
P
A
L
------
P
--
A
A
A
I
V
E
L
I
H
N
Y
S
L
I
Y
D
D
I
--
I
D
R
G
D
V
R
R
G
L
P
T
V
R
K
A
F
G
D
N
A
A
I
L
V
G
I
W
Y
R
E
A
I
E
E
-
A
V
L
D
--
T
P
K
P
T
L
F
A
K
E
V
A
---
E
V
I
K
A
I
D
E
G
E
R
L
D
I
--
L
F
E
A
A
G
R
S
D
P
Y
F
V
Q
A
---
R
-
W
----
R
-
E
---
V
T
L
D
D
Y
I
-----
K
M
V
S
L
K
T
G
A
L
I
A
A
A
A
K
W
G
V
L
S
V
-
S
D
D
R
G
-
L
A
E
A
A
W
N
-
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
D
------
E
I
G
K
D
I
K
E
H
K
--------------------------------------------------------------------------------------------
68
PsiBlast_CBE
30.07
38%
-55
- C1 -
4GP2
5
?
A:
[35-249]
-------------------------------------
E
A
V
L
Y
Q
V
K
T
G
G
K
R
L
R
P
L
L
T
L
A
A
A
E
A
V
S
--
G
Q
--
W
--
R
P
A
L
------
P
--
A
A
A
I
V
E
L
I
H
N
Y
S
L
I
Y
D
D
I
--
I
D
R
G
D
V
R
R
G
L
P
T
V
R
K
A
F
G
D
N
A
A
I
L
V
G
I
W
Y
R
E
A
I
E
E
-
A
V
L
D
--
T
P
K
P
T
L
F
A
K
E
V
A
---
E
V
I
K
A
I
D
E
G
E
R
L
D
I
--
L
F
E
A
A
G
R
S
D
P
Y
F
V
Q
A
---
R
-
W
----
R
-
E
---
V
T
L
D
D
Y
I
-----
K
M
V
S
L
K
T
G
A
L
I
A
A
A
A
K
W
G
V
L
S
V
-
S
D
D
R
G
-
L
A
E
A
A
W
N
-
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
D
P
K
K
F
G
K
E
I
G
K
D
I
K
E
H
K
--------------------------------------------------------------------------------------------
74
PsiBlast_CBE
28.64
34%
-61
- C1 -
3Q2Q
4
?
A:
[73-292]
----------------------------------------------
G
G
K
R
F
R
P
M
F
A
L
L
A
S
E
-
F
G
--
E
K
--
P
LS
E
N
V
I
------
K
--
A
A
V
V
V
E
I
T
H
L
A
T
L
Y
H
D
D
V
--
M
D
E
A
-------
S
A
N
A
R
W
D
N
S
V
A
I
L
A
G
D
I
L
L
A
H
A
S
G
-
L
M
S
Q
--
L
G
T
D
T
---
V
A
H
--------------------
F
A
E
T
F
G
E
--
L
V
T
G
Q
M
R
E
---
T
----
V
-
G
----
P
R
D
T
D
P
I
E
H
Y
T
N
V
I
R
E
K
T
G
V
L
I
A
S
A
G
Y
L
G
A
M
H
A
-
G
-
A
A
P
-
E
H
I
D
A
L
K
N
F
G
A
A
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
E
T
H
----
T
P
G
T
D
L
R
E
G
V
F
T
L
P
V
L
Y
A
L
R
E
D
T
P
----------------------------------
V
G
A
E
L
R
D
I
L
T
G
P
L
E
------------------------------