@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4098: (2016-02-23 )
MVFQHDIYAGQQVLVTGGSSGIGAAIAMQFAELGAEVVALGLDADGVHAPRHPRIRREELDITDSQRLQRLFEALPRLDVLVNNAGISRDREEYDLATFERVLRLNLSAAMLASQLARPLLAQRGGSILNIASMYSTFGSADRPAYSASKGAIVQLTRSLACEYAAERIRVNAIAPGWIDTPLGAGLKADVEATRRIMQRTPLARWGEAPEVASAAAFLCGPGASFVTGAVLAVDGGYLCA
Atome Classification :
(29 SA)
.........10........20........30........40..-------..----..----------.---------.------50---.---......-------.60-..------..-.....----70....----.-----.--------.----.80......--..--90-----.--.--....--..-----.100.......110-....-..-..-120..-..-....130.......140.......150.......160.....--..170.......180.---......190..---.---.------...---200.......210.......220........230.......240
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
F
QHDIYAG
Q
Q
V
L
V
TGGSS
G
I
G
A
A
I
A
M
Q
F
A
E
L
G
A
E
V
V
A
L
GLD-------AD----GV----------H---------A------PR---H---PRI
R
R
E-------EL--DI------T
D
-
S
Q
R
L
Q
----
R
L
F
E
AL----P-----
R
--------
L
----
D
V
L
VNNAGI--SR--
D
------
R
--
E
--EY
D
L
--
A
T
-----
F
E
R
V
L
R
LN
L
S
A
A
-
M
-
L
A
S
Q
-
L
A
-
R
P
-
L
L
-
A
Q-RG-G
S
I
L
N
I
A
S
M
Y
S
TFGSADRPAYSASK
G
A
I
V
Q
L
T
R
S
L
A
C
E
Y
A
A
E
--
R
I
R
V
N
A
IAPGWIDTPL---GAGLKA
D
V
E
A
T
---
R
---
R
------
I
M
Q
---RTPLARWGEA
P
E
V
A
S
A
A
A
FLCG-P
G
A
S
F
V
T
G
A
V
L
A
VDG
G
Y
LCA
2
PsiBlast_PDB
94.85
100%
-107
- C1 -
4AVY
-
?
A:
[1-241]
M
V
F
Q
H
D
I
Y
A
G
Q
Q
V
L
V
T
G
G
S
S
G
I
G
A
A
I
A
M
Q
F
A
E
L
G
A
E
V
V
A
L
G
L
D
-------
A
D
----
G
V
----------
H
---------
A
------
P
R
---
H
---
P
R
I
R
R
E
-------
E
L
--
D
I
------
T
D
-
S
Q
R
L
Q
----
R
L
F
E
A
L
----
P
-----
R
--------
L
----
D
V
L
V
N
N
A
G
I
--
S
R
--
D
------
R
--
E
--
E
Y
D
L
--
A
T
-----
F
E
R
V
L
R
L
N
L
S
A
A
-
M
-
L
A
S
Q
-
L
A
-
R
P
-
L
L
-
A
Q
-
R
G
-
G
S
I
L
N
I
A
S
M
Y
S
T
F
G
S
A
D
R
P
A
Y
S
A
S
K
G
A
I
V
Q
L
T
R
S
L
A
C
E
Y
A
A
E
--
R
I
R
V
N
A
I
A
P
G
W
I
D
T
P
L
---
G
A
G
L
K
A
D
V
E
A
T
---
R
---
R
------
I
M
Q
---
R
T
P
L
A
R
W
G
E
A
P
E
V
A
S
A
A
A
F
L
C
G
-
P
G
A
S
F
V
T
G
A
V
L
A
V
D
G
G
Y
L
C
A
1
PsiBlast_PDB
92.88
100%
-105
- C1 -
4B79
1
?
A:
[2-242]
M
V
F
Q
H
D
I
Y
A
G
Q
Q
V
L
V
T
G
G
S
S
G
I
G
A
A
I
A
M
Q
F
A
E
L
G
A
E
V
V
A
L
G
L
D
-------
A
D
----
G
V
----------
H
---------
A
------
P
R
---
H
---
P
R
I
R
R
E
-------
E
L
--
D
I
------
T
D
-
S
Q
R
L
Q
----
R
L
F
E
A
L
----
P
-----
R
--------
L
----
D
V
L
V
N
N
A
G
I
--
S
R
--
D
------
R
--
E
--
E
Y
D
L
--
A
T
-----
F
E
R
V
L
R
L
N
L
S
A
A
-
M
-
L
A
S
Q
-
L
A
-
R
P
-
L
L
-
A
Q
-
R
G
-
G
S
I
L
N
I
A
S
M
Y
S
T
F
G
S
A
D
R
P
A
Y
S
A
S
K
G
A
I
V
Q
L
T
R
S
L
A
C
E
Y
A
A
E
--
R
I
R
V
N
A
I
A
P
G
W
I
D
T
P
--------
K
A
D
V
E
A
T
---
R
---
R
------
I
M
Q
---
R
T
P
L
A
R
W
G
E
A
P
E
V
A
S
A
A
A
F
L
C
G
-
P
G
A
S
F
V
T
G
A
V
L
A
V
D
G
G
Y
L
C
A
21
PsiBlast_CBE
91.10
100%
-109
- C1 -
4B79
1
?
B:
[2-242]
M
V
F
Q
H
D
I
Y
A
G
Q
Q
V
L
V
T
G
G
S
S
G
I
G
A
A
I
A
M
Q
F
A
E
L
G
A
E
V
V
A
L
G
L
D
-------
A
D
----
G
V
----------
H
---------
A
------
P
R
---
H
---
P
R
I
R
R
E
-------
E
L
--
D
I
------
T
D
-
S
Q
R
L
Q
----
R
L
F
E
A
L
----
P
-----
R
--------
L
----
D
V
L
V
N
N
A
G
I
--
S
R
--
D
------
R
--
E
--
E
Y
D
L
--
A
T
-----
F
E
R
V
L
R
L
N
L
S
A
A
-
M
-
L
A
S
Q
-
L
A
-
R
P
-
L
L
-
A
Q
-
R
G
-
G
S
I
L
N
I
A
S
M
Y
S
T
F
G
S
A
D
R
P
A
Y
S
A
S
K
G
A
I
V
Q
L
T
R
S
L
A
C
E
Y
A
A
E
--
R
I
R
V
N
A
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A
P
G
W
I
D
T
-----------
D
V
E
A
T
---
R
---
R
------
I
M
Q
---
R
T
P
L
A
R
W
G
E
A
P
E
V
A
S
A
A
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F
L
C
G
-
P
G
A
S
F
V
T
G
A
V
L
A
V
D
G
G
Y
L
C
A
112
HHSearch
67.45
29%
-98
- C1 -
3TZQ
1
?
B:
[7-252]
-----
A
E
L
E
N
K
V
A
I
I
T
G
A
C
G
G
I
G
L
E
T
S
R
V
L
A
R
A
G
A
R
V
V
L
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-------
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----
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L
----------
A
---------
G
------
A
A
A
S
V
G
---
R
G
A
V
H
H
-------
V
V
--
D
L
------
T
N
-
E
V
S
V
R
----
A
L
I
D
F
T
I
D
T
F
G
-----
R
--------
L
----
D
I
V
D
N
N
A
A
H
--
S
D
--
P
ADML--
V
--
T
--
Q
M
T
V
--
D
V
-----
W
D
D
T
F
T
V
N
A
R
G
T
-
M
-
L
M
C
K
-
Y
A
-
I
P
-
R
L
-
I
S
A
G
G
-
G
A
I
V
N
I
S
S
A
T
A
H
A
A
Y
D
M
S
T
A
Y
A
C
T
K
A
A
I
E
T
L
T
R
Y
V
A
T
Q
Y
G
R
H
--
G
V
R
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N
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A
P
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---
L
E
---
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Q
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P
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V
---
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------
F
A
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---
H
H
L
A
G
R
I
G
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P
H
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A
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L
V
C
F
L
A
S
-
D
R
A
A
F
I
T
G
Q
V
I
A
A
D
S
G
L
L
A
-
83
PsiBlast_CBE
65.35
31%
-95
- C1 -
4NBU
1
?
A:
[17-249]
-------------
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
N
E
------
A
A
----
G
K
----------
E
---------
A
------
V
E
A
--
N
---
P
G
V
V
F
I
-------
R
V
--
D
V
------
S
D
-
R
E
S
V
H
----
R
L
V
E
N
V
----
A
E
R
FG-
K
--------
I
----
D
I
L
I
N
N
A
G
I
--
T
R
--
D
------
S
ML
S
--
K
M
T
V
--
D
Q
-----
F
Q
Q
V
I
N
V
N
L
T
G
V
-
F
-
H
C
T
Q
-
A
V
-
L
P
-
Y
M
-
A
E
-
Q
G
K
G
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
--
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
---
V
A
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P
E
K
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--
I
---
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---
K
------
M
K
A
---
Q
V
P
M
G
R
L
G
K
P
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D
I
A
N
A
Y
L
F
L
A
S
-
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
--
80
PsiBlast_CBE
64.79
31%
-95
- C1 -
4NBU
2
?
D:
[17-249]
-------------
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
N
E------
A
A
----
G
K
----------
E
---------
A
------
V
E
A--
N
---
P
G
V
V
F
I
-------
R
V
--
D
V
------
S
D
-
R
E
S
V
H
----
R
L
V
E
N
V
----
A
ERFG-
K
--------
I
----
D
I
L
I
N
N
A
G
I
--
T
R
--
D
------
S
ML
S
--
K
M
T
V
--
D
Q
-----
F
Q
Q
V
I
N
V
N
L
T
G
V
-
F
-
H
C
T
Q
-
A
V
-
L
P
-
Y
M
-
A
E
-
Q
G
K
G
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
T
N
Y
A
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A
K
A
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V
I
G
M
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K
T
W
A
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V
A
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P
E
K
V
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I
---
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---
K
------
M
K
A
---
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
-
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
--
117
HHSearch
64.39
43%
-96
- C1 -
2D1Y
1
?
A:
[2-247]
-----
G
L
F
A
G
K
G
V
L
V
T
G
G
A
R
G
I
G
R
A
I
A
Q
A
F
A
R
E
G
A
L
V
A
L
C
D
L
R
-------
P
E
----
G
K
----------
E
---------
V
------
A
E
---
A
---
I
G
G
A
F
F
-------
Q
V
--
D
L
------
E
D
-
E
R
E
R
V
----
R
F
V
E
E
A
A
Y
A
L
G
-----
R
--------
V
----
D
V
L
V
N
N
A
A
I
--
A
A
--
P
G
S
----
A
--
L
--
T
V
R
L
--
P
E
-----
W
R
R
V
L
E
V
N
L
T
A
P
-
M
-
H
L
S
A
-
L
A
-
A
R
-
E
M
-
R
K
V
G
G
-
G
A
I
V
N
V
A
S
V
Q
G
L
F
A
E
Q
E
N
A
A
Y
N
A
S
K
G
G
L
V
N
L
T
R
S
L
A
L
D
L
A
P
L
--
R
I
R
V
N
A
V
A
P
G
A
I
A
T
E
A
---
V
L
E
A
I
A
----
R
---
R
---
D
------
W
E
D
---
L
H
A
L
R
R
L
G
K
P
E
E
V
A
E
A
V
L
F
L
A
S
-
E
K
A
S
F
I
T
G
A
I
L
P
V
D
G
G
M
T
A
-
82
PsiBlast_CBE
63.55
31%
-95
- C1 -
4NBU
2
?
B:
[17-249]
-------------
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
N
E
------
A
A
----
G
K
----------
E
---------
A
------
V
E
A
--
N
---
P
G
V
V
F
I
-------
R
V
--
D
V
------
S
D
-
R
E
S
V
H
----
R
L
V
E
N
V
----
A
E
R
FG-
K
--------
I
----
D
I
L
I
N
N
A
G
I
--
T
R
--
D
------
S
ML
S
--
K
M
T
V
--
D
Q
-----
F
Q
Q
V
I
N
V
N
L
T
G
V
-
F
-
H
C
T
Q
-
A
V
-
L
P
-
Y
M
-
A
E
-
Q
G
K
G
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
--
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
---
V
A
E
V
P
E
K
V
--
I
---
E
---
K
------
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K
A
---
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
-
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
--
44
PsiBlast_CBE
63.32
34%
-101
- C1 -
4NBT
1
?
B:
[6-237]
---------
G
K
V
A
V
I
T
G
G
A
K
G
L
G
Q
A
I
A
L
A
Y
A
E
E
G
A
K
V
I
A
G
D
L
--------------
G
D
----------
L
---------
T
------
Y
S
---
H
---
P
N
V
E
G
M
-------
Y
L
--
N
V
------
T
D
-
V
T
G
V
E
----
K
F
Y
Q
S
V
IDKY
G
-----
K
--------
I
----
D
I
L
V
N
N
A
G
I
--
T
K
--
D
------
A
--
M
--
T
R
K
M
TE
A
Q
-----
W
D
A
V
I
D
V
N
L
K
G
V
-
F
-
N
L
T
R
-
L
V
-
G
P
-
Q
M
-
Q
T
-
N
G
Y
G
S
I
I
N
I
S
S
V
V
G
V
F
G
N
I
G
Q
A
N
Y
A
A
T
K
A
G
V
I
G
L
T
M
T
W
A
K
E
F
A
L
K
GA
N
V
R
V
N
A
I
A
P
G
Y
I
M
T
D
I
---
L
K
T
V
P
Q
D
L
--
L
---
D
---
K
------
F
A
A
---
L
T
M
L
N
R
L
G
Q
P
E
E
I
A
K
V
A
L
F
L
A
S
-
D
D
A
S
Y
V
T
G
Q
T
I
N
V
N
G
G
----
119
HHSearch
63.27
41%
-90
- C1 -
3UF0
1
?
A:
[25-272]
---
G
P
F
S
L
A
G
R
T
A
V
V
T
G
A
G
S
G
I
G
R
A
I
A
H
G
Y
A
R
A
G
A
H
V
L
A
W
G
R
T
-------
D
G
----
V
K
----------
E
---------
V
A
D
E
---
I
A
D
G
-
G
---
G
S
A
E
A
V
-------
V
A
--
D
L
------
A
D
-
L
E
G
A
A
----
N
V
A
E
E
L
A
A
T
-
R
-----
R
--------
V
----
D
V
L
V
N
N
A
G
I
--
I
A
--
R
A
P----
A
--
E
--
E
V
S
L
--
G
R
-----
W
R
E
V
L
T
V
N
L
D
A
A
-
W
-
V
L
S
R
-
S
F
-
G
T
-
A
M
-
L
A
H
G
S
-
G
R
I
V
T
I
A
S
M
L
S
F
Q
G
G
R
N
V
A
A
Y
A
A
S
K
H
A
V
V
G
L
T
R
A
L
A
S
E
W
A
G
R
--
G
V
G
V
N
A
L
A
P
G
Y
V
V
T
A
N
---
T
A
A
L
R
A
D
D
E
R
A
---
A
---
E
------
I
T
A
---
R
I
P
A
G
R
W
A
T
P
E
D
M
V
G
P
A
V
F
L
A
S
-
D
A
A
S
Y
V
H
G
Q
V
L
A
V
D
G
G
W
L
A
-
28
PsiBlast_CBE
63.19
40%
-91
- C1 -
3UF0
1
?
B:
[30-273]
--------
A
G
R
T
A
V
V
T
G
A
G
S
G
I
G
R
A
I
A
H
G
Y
A
R
A
G
A
H
V
L
A
W
G
-
R
-------
T
D
----
G
V
----------
K
EVADEIADG
G
------
G
S
---
A
---
E
A
V
V
A
D
-------
L
A
--
D
L
------
E
G
-
A
A
N
V
A
----
E
E
L
A
A
T
----
R
-----
R
--------
V
----
D
V
L
V
N
N
A
G
I
IA
R
A
--
P
------
A
--
E
--
E
V
S
L
--
G
R
-----
W
R
E
V
L
T
V
N
L
D
A
A
W
V
-
L
S
R
S
-
F
G
-
T
A
-
M
L
-
A
H
-
G
S
-
G
R
I
V
T
I
A
S
M
L
S
F
Q
G
G
R
N
V
A
A
Y
A
A
S
K
H
A
V
V
G
L
T
R
A
L
A
S
E
W
A
G
R
--
G
V
G
V
N
A
L
A
P
G
Y
V
V
T
A
N
---
T
A
A
L
R
A
D
D
E
R
A
---
A
---
E
------
I
T
A
---
R
I
P
A
G
R
W
A
T
P
E
D
M
V
G
P
A
V
F
L
A
S
-
D
A
A
S
Y
V
H
G
Q
V
L
A
V
D
G
G
W
L
A
S
81
PsiBlast_CBE
62.68
31%
-95
- C1 -
4NBU
1
?
C:
[17-249]
-------------
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
N
E------
A
A
----
G
K
----------
E
---------
A
------
V
E
A--
N
---
P
G
V
V
F
I
-------
R
V
--
D
V
------
S
D
-
R
E
S
V
H
----
R
L
V
E
N
V
----
A
ERFG-
K
--------
I
----
D
I
L
I
N
N
A
G
I
--
T
R
--
D
------
S
ML
S
--
K
M
T
V
--
D
Q
-----
F
Q
Q
V
I
N
V
N
L
T
G
V
-
F
-
H
C
T
Q
-
A
V
-
L
P
-
Y
M
-
A
E
-
Q
G
K
G
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
--
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
---
V
A
E
V
P
E
K
V
--
I
---
E
---
K
------
M
K
A
---
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
-
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
--
9
PsiBlast_PDB
62.62
40%
-89
- C1 -
3UF0
1
?
A:
[30-273]
--------
A
G
R
T
A
V
V
T
G
A
G
S
G
I
G
R
A
I
A
H
G
Y
A
R
A
G
A
H
V
L
A
W
G
-
R
-------
T
D
----
G
V
----------
K
E
V
A
D
E
I
A
D
G
G
------
G
S
---
A
---
E
A
V
V
A
D
-------
L
A
--
D
L
------
E
G
-
A
A
N
V
A
----
E
E
L
A
A
T
----
R
-----
R
--------
V
----
D
V
L
V
N
N
A
G
I
I
A
R
A
--
P
------
A
--
E
--
E
V
S
L
--
G
R
-----
W
R
E
V
L
T
V
N
L
D
A
A
W
V
-
L
S
R
S
-
F
G
-
T
A
-
M
L
-
A
H
-
G
S
-
G
R
I
V
T
I
A
S
M
L
S
F
Q
G
G
R
N
V
A
A
Y
A
A
S
K
H
A
V
V
G
L
T
R
A
L
A
S
E
W
A
G
R
--
G
V
G
V
N
A
L
A
P
G
Y
V
V
T
A
N
---
T
A
A
L
R
A
D
D
E
R
A
---
A
---
E
------
I
T
A
---
R
I
P
A
G
R
W
A
T
P
E
D
M
V
G
P
A
V
F
L
A
S
-
D
A
A
S
Y
V
H
G
Q
V
L
A
V
D
G
G
W
L
A
S
69
PsiBlast_CBE
62.31
34%
-102
- C1 -
2AE2
2
TRN2_DATST
A:
[9-255]
---------
G
C
T
A
L
V
T
G
G
S
R
G
I
G
Y
G
I
V
E
E
L
A
S
L
G
A
S
V
Y
T
C
S
R
N
-------
Q
K
----
E
L
----------
N
---------
D
C
L
T
Q
W
R
S
K
---
G
---
F
K
V
E
A
S
-------
V
C
--
D
L
------
S
S
-
R
S
E
R
Q
----
E
L
M
N
T
V
----
A
N
H
F
HG
K
--------
L
----
N
I
L
V
N
N
A
G
I
V
I
Y
K
--
E
------
A
--
K
--
D
Y
T
V
--
E
D
-----
Y
S
L
I
M
S
I
N
F
E
A
A
-
Y
-
H
L
S
V
-
L
A
-
H
P
-
F
L
K
A
S
-
E
R
-
G
N
V
V
F
I
S
S
V
S
G
A
L
A
V
P
Y
E
A
V
Y
G
A
T
K
G
A
M
D
Q
L
T
R
C
L
A
F
E
W
A
K
D
--
N
I
R
V
N
G
V
G
P
G
V
I
A
T
S
L
---
V
E
M
T
I
Q
D
P
E
Q
K
E
N
L
N
---
K
------
L
I
D
---
R
C
A
L
R
R
M
G
E
P
K
E
L
A
A
M
V
A
F
L
C
F
-
P
A
A
S
Y
V
T
G
Q
I
I
Y
V
D
G
G
L
M
--
19
PsiBlast_PDB
62.01
38%
-101
- C1 -
4DML
-
?
A:
[12-249]
-------------
L
V
T
G
A
S
R
G
I
G
R
A
I
A
L
E
L
A
A
A
G
A
K
V
A
V
N
Y
A
S
-------
S
A
----
G
A
----------
A
---------
D
------
E
V
---
V
---
A
A
I
A
A
A
G
G
E
A
F
A
V
K
A
--
D
V
------
S
Q
-
E
S
E
V
E
----
A
L
F
A
A
V
I
E
R
W
G
-----
R
--------
L
----
D
V
L
V
N
N
A
G
I
--
T
R
--
D
TLLL--
R
--
M
--
K
R
D
----
D
-----
W
Q
S
V
L
D
L
N
L
G
G
V
-
F
-
L
C
S
R
-
A
A
A
K
I
-
M
L
-
K
Q
-
R
S
-
G
R
I
I
N
I
A
S
V
V
G
E
M
G
N
P
G
Q
A
N
Y
S
A
A
K
A
G
V
I
G
L
T
K
T
V
A
K
E
L
A
S
R
--
G
I
T
V
N
A
V
A
P
G
F
I
A
T
D
M
--------
A
E
-----------
K
------
L
L
E
---
V
I
P
L
G
R
Y
G
E
A
A
E
V
A
G
V
V
R
F
L
A
A
D
P
A
A
A
Y
I
T
G
Q
V
I
N
I
D
G
G
L
V
M
A
43
PsiBlast_CBE
61.91
34%
-102
- C1 -
4NBT
1
?
C:
[6-237]
---------
G
K
V
A
V
I
T
G
G
A
K
G
L
G
Q
A
I
A
L
A
Y
A
E
E
G
A
K
V
I
A
G
D
L
--------------
G
D
----------
L
---------
T
------
Y
S
---
H
---
P
N
V
E
G
M
-------
Y
L
--
N
V
------
T
D
-
V
T
G
V
E
----
K
F
Y
Q
S
V
IDKY
G
-----
K
--------
I
----
D
I
L
V
N
N
A
G
I
--
T
K
--
D
------
A
--
M
--
T
R
K
M
TE
A
Q
-----
W
D
A
V
I
D
V
N
L
K
G
V
-
F
-
N
L
T
R
-
L
V
-
G
P
-
Q
M
-
Q
T
-
N
G
Y
G
S
I
I
N
I
S
S
V
V
G
V
F
G
N
I
G
Q
A
N
Y
A
A
T
K
A
G
V
I
G
L
T
M
T
W
A
K
E
F
A
L
K
GA
N
V
R
V
N
A
I
A
P
G
Y
I
M
T
D
I
---
L
K
T
V
P
Q
D
L
--
L
---
D
---
K
------
F
A
A
---
L
T
M
L
N
R
L
G
Q
P
E
E
I
A
K
V
A
L
F
L
A
S
-
D
D
A
S
Y
V
T
G
Q
T
I
N
V
N
G
G
----
58
PsiBlast_CBE
61.25
34%
-109
- C1 -
4WK6
2
?
C:
[12-247]
---------
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S
-------
E
S
----
G
A
----------
Q
---------
A
------
I
S
---
D
Y
L
G
D
N
G
K
G
M
-------
A
L
--
N
V
------
T
N
-
P
E
S
I
E
----
A
V
L
K
A
I
----
T
-----
D
E
FGG----
V
----
D
I
L
V
N
N
A
G
I
--
T
R
--
D
NLLMRM
K
--
E
--
E
------
E
-----
W
S
D
I
M
E
T
N
L
T
S
I
-
F
R
L
S
K
A
-
V
L
-
R
G
-
M
M
-
K
K
-
R
Q
-
G
R
I
I
N
V
A
S
V
V
G
------
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
--
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
---
T
K
A
L
N
-
D
E
Q
R
T
---
A
---
T
------
L
A
Q
----
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
-
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
----
59
PsiBlast_CBE
61.08
34%
-109
- C1 -
4WK6
1
?
B:
[12-247]
---------
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S
-------
E
S
----
G
A
----------
Q
---------
A
------
I
S
---
D
Y
L
G
D
N
G
K
G
M
-------
A
L
--
N
V
------
T
N
-
P
E
S
I
E
----
A
V
L
K
A
I
----
T
-----
D
E
FGG----
V
----
D
I
L
V
N
N
A
G
I
--
T
R
--
D
N
L
LMRM
K
--
E
--
E
------
E
-----
W
S
D
I
M
E
T
N
L
T
S
I
-
F
R
L
S
K
A
-
V
L
-
R
G
-
M
M
-
K
K
-
R
Q
-
G
R
I
I
N
V
A
S
V
V
G
T
M
----
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
--
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
---
T
K
A
L
N
-
D
E
Q
R
T
---
A
---
T
------
L
A
Q
----
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
-
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
----
68
PsiBlast_CBE
61.04
34%
-101
- C1 -
2AE2
2
TRN2_DATST
B:
[9-255]
---------
G
C
T
A
L
V
T
G
G
S
R
G
I
G
Y
G
I
V
E
E
L
A
S
L
G
A
S
V
Y
T
C
S
R
N
-------
Q
K
----
E
L
----------
N
---------
D
CLTQWR
S
K
---
G
---
F
K
V
E
A
S
-------
V
C
--
D
L
------
S
S
-
R
S
E
R
Q
----
E
L
M
N
T
V
----
A
NHFHG
K
--------
L
----
N
I
L
V
N
N
A
G
I
VI
Y
K
--
E
------
A
--
K
--
D
Y
T
V
--
E
D
-----
Y
S
L
I
M
S
I
N
F
E
A
A
-
Y
-
H
L
S
V
-
L
A
-
H
P
-
F
L
K
A
S
-
E
R
-
G
N
V
V
F
I
S
S
V
S
G
A
L
A
V
P
Y
E
A
V
Y
G
A
T
K
G
A
M
D
Q
L
T
R
C
L
A
F
E
W
A
K
D
--
N
I
R
V
N
G
V
G
P
G
V
I
A
T
S
L
---
V
E
M
T
I
Q
D
P
E
Q
K
ENL
N
---
K
------
L
I
D
---
R
C
A
L
R
R
M
G
E
P
K
E
L
A
A
M
V
A
F
L
C
F
-
P
A
A
S
Y
V
T
G
Q
I
I
Y
V
D
G
G
L
M
--
6
PsiBlast_PDB
60.83
34%
-100
- C1 -
2PNF
3
FABG_AQUAE
A:
[7-248]
---------
G
K
V
S
L
V
T
G
S
T
R
G
I
G
R
A
I
A
E
K
L
A
S
A
G
S
T
V
I
I
T
G
T
S
G
E
R
A
K
A
V
A
E
----
E
I
----------
A
---------
N
------
K
Y
---
G
---
V
K
A
H
G
V
-------
E
M
--
N
L
------
L
S
-
E
E
S
I
N
----
K
A
F
E
E
I
----
Y
-----
N
--------
L
VDGI
D
I
L
V
N
N
A
G
I
--
T
R
--
D
------
K
--
L
FL
R
M
S
L
--
L
D
-----
W
E
E
V
L
K
V
N
L
T
G
T
-
F
-
L
V
T
Q
-
N
S
L
R
K
-
M
I
-
K
Q
-
R
W
-
G
R
I
V
N
I
S
S
V
V
G
F
T
G
N
V
G
Q
V
N
Y
S
T
T
K
A
G
L
I
G
F
T
K
S
L
A
K
E
L
A
P
R
--
N
V
L
V
N
A
V
A
P
G
F
I
E
T
D
M
---
T
A
V
L
S
E
E
I
K
-----
Q
---
K
------
Y
K
E
---
Q
I
P
L
G
R
F
G
S
P
E
E
V
A
N
V
V
L
F
L
C
S
-
E
L
A
S
Y
I
T
G
E
V
I
H
V
N
G
G
M
F
--
18
PsiBlast_PDB
59.34
36%
-101
- C1 -
3O03
3
?
A:
[34-282]
---------
G
K
I
A
L
V
T
G
A
S
Y
G
I
G
F
A
I
A
S
A
Y
A
K
A
G
A
T
I
V
F
N
D
I
N
-------
Q
E
L
V
D
R
G
M
----------
A
---------
A
------
Y
K
---
A
---
A
G
I
N
A
H
-------
G
Y
V
C
D
V
------
T
D
-
E
D
G
I
Q
----
A
M
V
A
Q
I
----
E
-----
S
E
VGI----
I
----
D
I
L
V
N
N
A
G
I
--
I
R
--
R
------
V
--
P
MI
E
M
T
A
--
A
Q
-----
F
R
Q
V
I
D
I
D
L
N
A
P
-
F
-
I
V
S
K
-
A
V
-
I
P
-
S
M
-
I
K
-
K
G
H
G
K
I
I
N
I
C
S
M
M
S
E
L
G
R
E
T
V
S
A
Y
A
A
A
K
G
G
L
K
M
L
T
K
N
I
A
S
E
Y
G
E
A
--
N
I
Q
C
N
G
I
G
P
G
Y
I
A
T
P
Q
---
T
------------------H
P
F
D
Q
F
I
I
A
---
K
T
P
A
A
R
W
G
E
A
E
D
L
M
G
P
A
V
F
L
A
S
-
D
A
S
N
F
V
N
G
H
I
L
Y
V
D
G
G
I
L
--
86
PsiBlast_CBE
57.41
36%
-109
- C1 -
2DTE
1
?
B:
[11-245]
------------
V
I
V
T
G
A
S
M
G
I
G
R
A
I
A
E
R
F
V
D
E
G
S
K
V
I
D
L
S
----------------
I
----------
H
---------
D
------
P
G
---
E
---
A
K
Y
D
H
I
-------
E
C
--
D
V
------
T
N
-
P
D
Q
V
K
ASID
H
I
F
K
E
Y
----
G
-----
S
--------
I
----
S
V
L
V
N
N
A
G
I
--
E
S
YG
K
------
I
--
E
--
S
M
S
M
--
G
E
-----
W
R
R
I
I
D
V
N
L
F
G
Y
-
Y
-
Y
A
S
K
-
F
A
-
I
P
Y
M
I
-
R
S
-
R
D
-
P
S
I
V
N
I
S
S
V
Q
A
S
I
I
T
K
N
A
S
A
Y
V
T
S
K
H
A
V
I
G
L
T
K
S
I
A
L
D
Y
A
P
---
L
L
R
C
N
A
V
C
P
A
T
I
D
T
P
L
VRK
A
A
E
L
E
V
G
S
D
P
M
---
R
IEK
K
------
I
S
E
WGH
E
H
P
M
Q
R
I
G
K
P
Q
E
V
A
S
A
V
A
F
L
A
S
-
R
E
A
S
F
I
T
G
T
C
L
Y
V
D
G
G
----
87
PsiBlast_CBE
57.36
36%
-109
- C1 -
2DTE
1
?
A:
[11-245]
------------
V
I
V
T
G
A
S
M
G
I
G
R
A
I
A
E
R
F
V
D
E
G
S
K
V
I
D
L
S
----------------
I
----------
H
---------
D
------
P
G
---
E
---
A
K
Y
D
H
I
-------
E
C
--
D
V
------
T
N
-
P
D
Q
V
K
A
S
I
D
H
I
F
K
E
Y
----
G
-----
S
--------
I
----
S
V
L
V
N
N
A
G
I
--
E
S
Y
G
K
------
I
--
E
--
S
M
S
M
--
G
E
-----
W
R
R
I
I
D
V
N
L
F
G
Y
-
Y
-
Y
A
S
K
-
F
A
-
I
P
Y
M
I
-
R
S
-
R
D
-
P
S
I
V
N
I
S
S
V
Q
A
S
I
I
T
K
N
A
S
A
Y
V
T
S
K
H
A
V
I
G
L
T
K
S
I
A
L
D
Y
A
P
---
L
L
R
C
N
A
V
C
P
A
T
I
D
T
P
L
V
R
K
A
A
E
L
E
V
G
S
D
P
M
---
R
I
E
K
K
------
I
S
E
W
G
H
E
H
P
M
Q
R
I
G
K
P
Q
E
V
A
S
A
V
A
F
L
A
S
-
R
E
A
S
F
I
T
G
T
C
L
Y
V
D
G
G
----
75
PsiBlast_CBE
56.96
34%
-98
- C1 -
4I08
6
FABG_VIBCH
A:
[12-247]
---------
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S
-------
E
S
----
G
A
----------
Q
---------
A
------
I
S
---
D
Y
L
G
D
N
G
K
G
M
-------
A
L
--
N
V
------
T
N
-
P
E
S
I
E
----
A
V
L
K
A
I
----
T
-----
D
E
FGG----
V
----
D
I
L
V
N
N
A
G
I
--
T
R
--
D
NLLMRM
K
--
E
--
E
------
E
-----
W
S
D
I
M
E
T
N
L
T
S
I
-
F
R
L
S
K
A
-
V
L
-
R
G
-
M
M
-
K
K
-
R
Q
-
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
--
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
-------
N
-
D
E
Q
R
T
---
A
---
T
------
L
A
Q
----
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
-
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
----
3
PsiBlast_PDB
54.54
39%
-82
- C1 -
4HP8
2
?
A:
[9-246]
---------
G
R
K
A
L
V
T
G
A
N
T
G
L
G
Q
A
I
A
V
G
L
A
A
A
G
A
E
V
V
-------------------
C
----------
A
---------
A
------
R
R
---
A
---
P
D
---
E
-------
T
L
--
D
I
I
A
K
D
G
G
N
A
-
S
A
L
L
I
----
D
F
A
D
P
L
----
A
-----
A
KDSFTDAG
F
----
D
I
L
V
N
N
A
G
I
--
I
R
R
A
D
------
S
--
V
--
E
F
S
E
--
L
D
-----
W
D
E
V
M
D
V
N
L
K
A
L
-
F
-
F
T
T
Q
A
F
A
-
K
E
-
L
L
-
A
K
G
R
S
-
G
K
V
V
N
I
A
S
L
L
S
F
Q
G
G
I
R
V
P
S
Y
T
A
A
K
H
G
V
A
G
L
T
K
L
L
A
N
E
W
A
A
K
--
G
I
N
V
N
A
I
A
P
G
Y
I
E
T
N
N
---
T
E
A
L
R
A
D
A
A
R
N
---
K
---
A
------
I
L
E
---
R
I
P
A
G
R
W
G
H
S
E
D
I
A
G
A
A
V
F
L
S
S
-
A
A
A
D
Y
V
H
G
A
I
L
N
V
D
G
G
W
L
A
-
22
PsiBlast_CBE
53.32
39%
-84
- C1 -
4HP8
1
?
B:
[9-246]
---------
G
R
K
A
L
V
T
G
A
N
T
G
L
G
Q
A
I
A
V
G
L
A
A
A
G
A
E
V
V
-------------------
C
----------
A
---------
A
------
R
R
---
A
---
P
D
---
E
-------
T
L
--
D
I
I
A
K
D
G
G
N
A
-
S
A
L
L
I
----
D
F
A
D
P
L
----
A
-----
A
KDSFTDAG
F
----
D
I
L
V
N
N
A
G
I
--
I
R
R
A
D
------
S
--
V
--
E
F
S
E
--
L
D
-----
W
D
E
V
M
D
V
N
L
K
A
L
-
F
-
F
T
T
Q
A
F
A
-
K
E
-
L
L
-
A
K
G
R
S
-
G
K
V
V
N
I
A
S
L
L
S
F
Q
G
G
I
R
V
P
S
Y
T
A
A
K
H
G
V
A
G
L
T
K
L
L
A
N
E
W
A
A
K
--
G
I
N
V
N
A
I
A
P
G
Y
I
E
T
N
N
---
T
E
A
L
R
A
D
A
A
R
N
---
K
---
A
------
I
L
E
---
R
I
P
A
G
R
W
G
H
S
E
D
I
A
G
A
A
V
F
L
S
S
-
A
A
A
D
Y
V
H
G
A
I
L
N
V
D
G
G
W
L
A
-
51
PsiBlast_CBE
48.61
37%
-87
- C1 -
2CFC
2
HCDR_XANP2
A:
[6-247]
-------------
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
L
D
L
S
-------
A
E
----
T
L
E
E
T
A
R
T
HWHA
Y
---------
A
------
D
K
---
V
---
L
R
V
R
A
D
-------
V
A
--
D
E
------
G
D
V
N
A
A
I
A
----
A
T
M
E
Q
F
----
G
-----
A
--------
I
----
D
V
L
V
N
N
A
G
I
--
T
G
--
N
------
S
--
E
--
A
G
V
L
--
H
T
TP
V
E
Q
F
D
K
V
M
A
V
N
V
R
G
I
-
F
-
L
G
C
R
-
A
V
-
L
P
H
M
L
-
L
Q
-
G
A
-
G
V
I
V
N
I
A
S
V
A
S
L
V
A
F
P
G
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
--
G
I
R
C
N
A
V
C
P
G
M
I
E
T
P
M
---
T
Q
W
R
L
D
Q
P
E
L
R
---
D
---
Q
------
V
L
A
---
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
-
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
---
50
PsiBlast_CBE
48.16
37%
-86
- C1 -
2CFC
2
HCDR_XANP2
B:
[6-247]
-------------
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
L
D
L
S
-------
A
E
----
T
L
EETARTHWHA
Y
---------
A
------
D
K
---
V
---
L
R
V
R
A
D
-------
V
A
--
D
E
------
G
D
V
N
A
A
I
A
----
A
T
M
E
Q
F
----
G
-----
A
--------
I
----
D
V
L
V
N
N
A
G
I
--
T
G
--
N
------
S
--
E
--
A
G
V
L
--
H
T
TPVEQ
F
D
K
V
M
A
V
N
V
R
G
I
-
F
-
L
G
C
R
-
A
V
-
L
P
H
M
L
-
L
Q
-
G
A
-
G
V
I
V
N
I
A
S
V
A
S
L
V
A
F
P
G
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
--
G
I
R
C
N
A
V
C
P
G
M
I
E
T
P
M
---
T
Q
W
R
L
D
Q
P
E
L
R
---
D
---
Q
------
V
L
A
---
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
-
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
---
49
PsiBlast_CBE
47.66
37%
-84
- C1 -
2CFC
2
HCDR_XANP2
C:
[6-247]
-------------
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
L
D
L
S
-------
A
E
----
T
L
EETARTHWHA
Y
---------
A
------
D
K
---
V
---
L
R
V
R
A
D
-------
V
A
--
D
E
------
G
D
V
N
A
A
I
A
----
A
T
M
E
Q
F
----
G
-----
A
--------
I
----
D
V
L
V
N
N
A
G
I
--
T
G
--
N
------
S
--
E
--
A
G
V
L
--
H
T
TPVEQ
F
D
K
V
M
A
V
N
V
R
G
I
-
F
-
L
G
C
R
-
A
V
-
L
P
H
M
L
-
L
Q
-
G
A
-
G
V
I
V
N
I
A
S
V
A
S
L
V
A
F
P
G
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
--
G
I
R
C
N
A
V
C
P
G
M
I
E
T
P
M
---
T
Q
W
R
L
D
Q
P
E
L
R
---
D
---
Q
------
V
L
A
---
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
-
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
---