@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4143: (2016-02-24 )
MAFLDALALRLGRRLPLVLQTEATECGLACLAMIAGYHGHHTGLMELRRRFSVSLKGISLKQLIQTAHRLGLGTRAVKLDLGDLGKLKLPCVLHWNFNHFVVLKAVDGRGAVLHDPAHGQRRLGLEEVSRSFTGVALELWPESGFEKQEAPPRIKLLGMLGKVTGLYRSLAQVLLLAGALEVFSLISPFFLQWTIDNVIVSEDRDLLSTLAIGFGLLLLMQQAVSGVRAWVMMHMSTLLGVQWQANVFSHLLRLPAQYFEKRHLGDVVSRFGAVNSIQQTLTAAFLSAVLDGLMTVATLGMMLLYSPPLAAIAIAAMSLYALGRWIWYRPLRNATEEQIVHAARQQSHFLETVRGIRPLKLFQRQDERRSVWLGLLVEQINAGLRTQKLQLFYQQLNGLLFGVENLLVIWLGATMVMDGQFSVGILMAFNAYKSQFDSRVGSLIDKFFELRMLQLQGERLADIVLQAPEVSHGDILPENLREREASIEIQGLRYRYAEQEPWVLDGLDLRIAGGESVAIVGPSGCGKSTLFNVLLGILPPVEGQIRMAGLDLAQLGLDGLRELVGTVLQDDVLFAGSLSDNISFFDPQPDMPWLLQCAQMAAIHDDIQAMPMGYNTLVGDMGTVLSGGQKQRVMLARALYKKPRILFLDEATSHLDVHCEQRVNAAIRALRITRIMVAHRPETIASADRVIVLGQGKVSLDESTARLAERQAAAAREQA
Atome Classification :
(72 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20.....------...30........40........50........60........70........80.....-...90.......----.100.......110.......120.......130.......140.......150.......160.......170....---....180.-.......190.......-----200--..--.---....---.210.....---------.--.220.......230.......240.......250.......--260.......270.-.-....-..280-.........290.....-..300..-.--....310.....---..320.......330.......340.......350.......360.......370.......380....--...390.----.......400...-------.---...410.......420.......430.......440.......450.......460.......470..---.------....480....----...490....-...-500.......510.......520.......530.......540--........550.......560.......570.......580..-.---..-.---.-590.......600....---...610.......620.......630.......640.......650.......660-.-......670--.--.-------..--.....680.......690.......700.......710.......----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
L
D
A
L
A
L
R
LGRRL
P
L
V
L
QTE
A
T
E
C
------
G
L
A
C
L
A
M
I
AGYHGHH
T
G
L
M
E
L
R
R
R
F
S
VSLKG
I
S
L
K
Q
L
I
Q
T
A
H
RLGLG
T
R
A
V
K
LDLGDLGK-LK
L
P
C
V
L
H
WNF
N
----
H
F
V
V
L
K
AVDGR
G
A
V
LHDPAH
G
Q
RRL
G
L
E
E
V
S
R
SFT
G
V
A
L
E
LWPESGFEKQEAP
P
R
I
K
L
L
G
M
L
G
K
V
T
G
L
Y
R
S
L
-
A
Q
V
L
L
---
L
A
G
A
L
-
E
V
-
F
S
L
I
S
P
F
F
L
Q
W
T
ID
N
V
I
-----VS---E
D
--
R
---
D
L
L
S
---
T
L
A
I
G
F
G
L
L
---------
L
--
L
M
Q
Q
A
V
S
G
V
R
A
W
V
M
M
H
M
S
T
L
LG
V
Q
W
Q
A
N
V
F
S
H
L
L
R
L
P
A
Q
Y
F
--
E
K
R
H
L
G
D
V
V
S
R
-FG-
A
-
V
N
S
I
-
Q
Q
T
---
L
T
A
A
F
L
S
A
V
L
D
G
L
M
T
V
A
-
T
L
G
M
M
L
L-Y--SP
P
L
A
A
I
A
I
A
A
M
---
S
L
Y
A
L
G
R
W
I
W
Y
R
PLRNA
T
E
E
Q
I
V
H
A
A
R
Q
Q
S
H
F
L
E
T
V
RGIR
P
L
K
L
F
Q
R
Q
D
E
R
R
S
V
W
L
G
L
L
V
E
Q
I
NAGL
R
T
--
Q
K
L
Q
-
L
F
----
Y
Q
Q
L
N
G
L
L
F
G
V
E
N
-------
L
---
L
V
I
W
LG
A
T
M
V
MDGQ
F
S
V
G
I
L
M
A
F
N
A
Y
K
S
Q
F
D
S
R
V
G
S
L
I
D
K
F
F
E
L
R
M
L
Q
LQ
G
E
R
L
A
D
I
V
LQAPEVSHGD---I------L
P
E
N
L
R
E
R
E
A
S
----
I
E
I
Q
G
L
R
Y
R
Y-AEQ-EP
W
V
LDG
L
D
L
R
I
AGG
E
S
V
A
I
VGPSGC
G
K
S
T
L
F
N
V
L
L
G
ILPPV---EG
Q
I
R
M
A
G
L
D
L
A
Q
L
G
L
D
G
L
R
E
L
V
G
T
V
L
QDD
V
L
F
AGSLSDN
I
S
F-F---DP-Q---P-D
M
P
W
L
L
Q
C
A
Q
M
A
A
I
H
D
D
---
I
Q
AMPMG
Y
N
T
L
V
G
D
M
G
T
VLSGG
Q
K
Q
R
V
M
L
A
R
A
L
YKKP
R
I
L
F
L
DEATS
H
L
D
V
H
C
E
Q
R
-
V
-
N
A
A
I
R
A
L
----
R
--
I
-------
T
R
--
I
M
V
AHRPETIASA
D
R
V
I
V
L
GQ
G
K
V
SL
D
E
S
T
A
R
L
A
E
R
Q
A
A
AAREQA----
1
PsiBlast_PDB
92.64
29%
-116
- C2 -
4RY2
-
?
A:
[15-701]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
R
Q
Y
D
L
T
D
C
------
G
A
A
C
L
S
S
I
A
Q
Y
Y
G
L
K
M
S
L
A
K
I
R
E
M
T
G
T
D
T
Q
G
T
N
A
Y
G
L
I
H
A
A
K
Q
L
G
F
S
A
K
G
V
K
A
S
K
E
D
L
L
K
D
F
R
L
P
A
I
A
N
V
I
V
D
NRLA
H
F
V
V
I
Y
S
I
K
N
R
I
I
T
V
A
D
P
G
K
G
I
V
R
Y
S
M
D
D
F
C
S
I
W
T
G
G
L
V
L
L
E
P
G
E
A
F
Q
K
G
D
Y
T
Q
N
-----
M
M
V
K
F
A
G
F
L
K
P
L
-
K
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
-
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
-----
K
F
---
E
K
--
L
---
N
D
L
H
---
I
I
S
A
G
F
A
V
I
---------
F
--
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
--
N
S
R
K
V
G
E
I
I
S
R
-
F
M
-
D
-
A
S
K
I
-
R
Q
A
---
I
S
G
A
T
L
T
I
M
I
D
T
I
M
--
A
-
V
I
G
G
I
L
L
-
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
---
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
--
G
M
L
Y
-
I
N
----
L
S
S
L
T
G
I
V
A
G
L
G
G
-------
I
---
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
A
T
E
K
E
L
---------------------
G
D
----
I
E
F
R
N
V
D
F
R
Y
-
G
L
R
-
K
P
-
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
-
G
---
N
E
-
N
---
V
-
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
---
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
-
I
-
K
D
A
I
Y
G
L
----
E
DD
V
-------
T
V
--
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
-------------------------
6
PsiBlast_PDB
80.46
27%
-119
- C1 -
3QF4
1
Y288_THEMA
B:
[21-567]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
-
I
M
V
F
V
---
F
V
T
V
S
-
S
I
-
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
-----
V
P
---
R
R
--
F
---
D
L
L
P
---
R
Y
M
L
I
L
G
T
I
---------
Y
--
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
--
D
R
T
P
H
G
D
I
I
S
R
V
I
N
-
D
-
V
D
N
I
-
N
N
V
---
L
G
N
S
I
I
Q
-
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
-
V
--
N
V
I
L
S
L
V
T
L
S
I
V
---
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
-----
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
-
I
F
----
S
G
V
L
P
P
L
M
N
M
V
N
N
-------
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
---
A
------
V
--
E
L
R
E
V
R
G
E
----
I
E
F
K
N
V
W
F
S
Y
-
D
K
K
-
K
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
-
G
---
N
P
-
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
---
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
-
I
-
Q
A
A
M
W
K
L
----
M
EG
K
-------
T
S
--
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
-------------------------
7
PsiBlast_PDB
79.30
27%
-122
- C1 -
4Q4A
1
Y288_THEMA
B:
[21-567]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
-
I
M
V
F
V
---
F
V
T
V
S
-
S
I
-
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
-----
V
P
---
R
R
--
F
---
D
L
L
P
---
R
Y
M
L
I
L
G
T
I
---------
Y
--
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
--
D
R
T
P
H
G
D
I
I
S
R
V
I
N
-
D
-
V
D
N
I
-
N
N
V
---
L
G
N
S
I
I
Q
-
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
-
V
--
N
V
I
L
S
L
V
T
L
S
I
V
---
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
-----
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
-
I
F
----
S
G
V
L
P
P
L
M
N
M
V
N
N
-------
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
---
A
------
V
--
E
L
R
E
V
R
G
E
----
I
E
F
K
N
V
W
F
S
Y
-
D
K
K
-
K
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
-
G
---
N
P
-
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
---
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
-
I
-
Q
A
A
M
W
K
L
----
M
EG
K
-------
T
S
--
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
-------------------------
9
PsiBlast_PDB
79.17
27%
-119
- C1 -
4Q4J
-
Y288_THEMA
B:
[21-567]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
-
I
M
V
F
V
---
F
V
T
V
S
-
S
I
-
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
-----
V
P
---
R
R
--
F
---
D
L
L
P
---
R
Y
M
L
I
L
G
T
I
---------
Y
--
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
--
D
R
T
P
H
G
D
I
I
S
R
V
I
N
-
D
-
V
D
N
I
-
N
N
V
---
L
G
N
S
I
I
Q
-
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
-
V
--
N
V
I
L
S
L
V
T
L
S
I
V
---
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
-----
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
-
I
F
----
S
G
V
L
P
P
L
M
N
M
V
N
N
-------
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
---
A
------
V
--
E
L
R
E
V
R
G
E
----
I
E
F
K
N
V
W
F
S
Y
-
D
K
K
-
K
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
-
G
---
N
P
-
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
---
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
-
I
-
Q
A
A
M
W
K
L
----
M
EG
K
-------
T
S
--
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
-------------------------
8
PsiBlast_PDB
79.14
27%
-116
- C1 -
4Q4H
-
Y288_THEMA
B:
[21-567]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
-
I
M
V
F
V
---
F
V
T
V
S
-
S
I
-
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
-----
V
P
---
R
R
--
F
---
D
L
L
P
---
R
Y
M
L
I
L
G
T
I
---------
Y
--
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
--
D
R
T
P
H
G
D
I
I
S
R
V
I
N
-
D
-
V
D
N
I
-
N
N
V
---
L
G
N
S
I
I
Q
-
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
-
V
--
N
V
I
L
S
L
V
T
L
S
I
V
---
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
-----
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
-
I
F
----
S
G
V
L
P
P
L
M
N
M
V
N
N
-------
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
---
A
------
V
--
E
L
R
E
V
R
G
E
----
I
E
F
K
N
V
W
F
S
Y
-
D
K
K
-
K
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
-
G
---
N
P
-
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
---
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
-
I
-
Q
A
A
M
W
K
L
----
M
EG
K
-------
T
S
--
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
-------------------------
112
HHSearch
79.05
28%
-113
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[8-572]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
-
A
V
G
---
F
L
T
M
S
-
S
V
-
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
-----
T
N
---
P
T
--
V
DY
S
D
N
L
T
---
R
L
C
L
G
L
S
A
V
---------
F
--
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
--
D
K
T
R
T
G
E
L
I
N
R
-
L
S
S
D
-
T
A
L
L
-
G
R
S
---
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
-
G
I
S
M
M
F
F
-
V
--
S
P
N
L
A
T
F
V
L
S
V
V
---
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
--
A
F
A
R
-
A
G
----
F
F
G
A
T
G
L
S
G
N
L
I
V
-------
L
---
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
---
G
V
I
L
---
N
E
K
S
F
---
Q
G
A
----
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
-
G
---
A
D
-
D
PSS
V
-
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
---
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
-
V
-
Q
E
A
L
D
R
L
M
D--
G
--
R
-------
T
V
--
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
------------
4
PsiBlast_PDB
75.17
27%
-110
- C1 -
2ONJ
4
Y1866_STAAM
A:
[14-568]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
I
F
-
A
T
I
I
V
-----
G
I
I
-
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
NNHAL
T
T
---
D
E
--
K
---
V
H
H
L
---
T
I
A
I
G
I
A
L
F
---------
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
--
A
N
N
Q
V
G
Q
V
I
S
R
----
V
-
I
N
D
V
-
E
Q
T
K
DF
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
-
A
L
S
I
M
F
F
-
L
--
D
V
K
L
T
L
A
A
L
F
I
F
---
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
-----
D
K
K
N
T
N
F
L
T
--
R
A
L
K
-------
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
---
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
----
V
------
G
A
Q
P
I
E
I
K
Q
G
R
----
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
-
G
---
R
P
-
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
---
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
-
I
-
Q
E
A
L
D
V
L
----
S
--
K
-------
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
----------
3
PsiBlast_PDB
74.91
27%
-110
- C1 -
2HYD
3
Y1866_STAAM
A:
[14-568]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
I
F
-
A
T
I
I
V
-----
G
I
I
-
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
NNHAL
T
T
---
D
E
--
K
---
V
H
H
L
---
T
I
A
I
G
I
A
L
F
---------
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
--
A
N
N
Q
V
G
Q
V
I
S
R
----
V
-
I
N
D
V
-
E
Q
T
K
DF
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
-
A
L
S
I
M
F
F
-
L
--
D
V
K
L
T
L
A
A
L
F
I
F
---
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
-----
D
K
K
N
T
N
F
L
T
--
R
A
L
K
-------
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
---
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
----
V
------
G
A
Q
P
I
E
I
K
Q
G
R
----
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
-
G
---
R
P
-
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
---
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
-
I
-
Q
E
A
L
D
V
L
----
S
--
K
-------
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
----------
14
PsiBlast_PDB
74.00
25%
-115
- C1 -
4MYC
-
ATM1_YEAST
A:
[2-553]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
W
P
-----
K
G
N
N
K
V
R
I
R
V
L
I
A
L
G
-------------
L
L
---
I
S
A
---
K
I
-
L
N
V
Q
V
P
F
F
F
K
Q
T
I
D
S
M
N
-----
I
A
W--
D
D
--
P
---
T
V
A
L
---
P
A
A
I
G
L
T
I
L
C
Y
G
V
A
R
F
G
S
V
--
L
F
G
E
L
R
N
A
V
F
A
K
V
A
Q
N
A
I
R
T
V
S
L
Q
----
T
F
Q
H
L
M
K
L
D
L
G
W
H
--
L
S
R
Q
T
G
G
L
T
R
A
-
M
D
R
G
-
T
K
G
I
-
S
Q
V
---
L
T
A
M
V
F
H
I
I
P
I
S
F
E
I
S
V
-
V
C
G
I
L
T
Y
Q
F
--
G
A
S
F
A
A
I
T
F
S
T
M
L
L
Y
S
I
F
T
I
K
T
T
A
W
R
T
H
F
R
R
D
A
N
K
A
D
N
K
A
A
---
S
V
A
L
D
S
L
I
N
F
E
A
V
K
Y
F
N
N
E
K
Y
L
A
D
K
Y
N
G
S
L
M
N
Y
R
D
S
Q
I
K
V
--
S
Q
S
L
-
A
F
----
L
N
S
G
Q
N
L
I
F
T
T
A
L
-------
T
---
A
M
M
Y
M
G
C
T
G
V
I
G
G
N
L
T
V
G
D
L
V
L
I
N
Q
L
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
R
D
L
K
Q
S
L
I
D
M
E
T
L
F
K
L
R
K
N
E
V
K
I
K
N
A
E
RPL
M
------
L
P
E
N
V
---
P
Y
D
----
I
T
F
E
N
V
T
F
G
Y
-
H
P
D
-
R
K
-
I
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
Y
D
P
E
---
S
G
R
I
L
I
N
G
R
D
I
K
E
Y
D
I
D
A
L
R
K
V
I
G
V
V
P
Q
D
T
P
L
F
N
D
T
I
W
E
N
V
K
F
-
G
---
R
I
-
D
---
A
-
T
D
E
E
V
I
T
V
V
E
K
A
Q
L
A
P
L
---
I
K
K
L
P
Q
G
F
D
T
I
V
G
E
R
G
L
M
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
-----
A
L
L
R
T
I
----
R
--
D
N
F
TSGS
R
T
S
--
V
Y
I
A
H
R
L
R
T
I
A
D
A
D
K
I
I
V
L
D
N
G
R
V
-------------------------
15
PsiBlast_PDB
73.52
25%
-114
- C1 -
4MYH
-
ATM1_YEAST
A:
[2-553]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
W
P
-----
K
G
N
N
K
V
R
I
R
V
L
I
A
L
G
-------------
L
L
---
I
S
A
---
K
I
-
L
N
V
Q
V
P
F
F
F
K
Q
T
I
D
S
M
N
-----
I
A
W--
D
D
--
P
---
T
V
A
L
---
P
A
A
I
G
L
T
I
L
C
Y
G
V
A
R
F
G
S
V
--
L
F
G
E
L
R
N
A
V
F
A
K
V
A
Q
N
A
I
R
T
V
S
L
Q
----
T
F
Q
H
L
M
K
L
D
L
G
W
H
--
L
S
R
Q
T
G
G
L
T
R
A
-
M
D
R
G
-
T
K
G
I
-
S
Q
V
---
L
T
A
M
V
F
H
I
I
P
I
S
F
E
I
S
V
-
V
C
G
I
L
T
Y
Q
F
--
G
A
S
F
A
A
I
T
F
S
T
M
L
L
Y
S
I
F
T
I
K
T
T
A
W
R
T
H
F
R
R
D
A
N
K
A
D
N
K
A
A
---
S
V
A
L
D
S
L
I
N
F
E
A
V
K
Y
F
N
N
E
K
Y
L
A
D
K
Y
N
G
S
L
M
N
Y
R
D
S
Q
I
K
V
--
S
Q
S
L
-
A
F
----
L
N
S
G
Q
N
L
I
F
T
T
A
L
-------
T
---
A
M
M
Y
M
G
C
T
G
V
I
G
G
N
L
T
V
G
D
L
V
L
I
N
Q
L
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
R
D
L
K
Q
S
L
I
D
M
E
T
L
F
K
L
R
K
N
E
V
K
I
K
N
A
E
RPL
M
------
L
P
E
N
V
---
P
Y
D
----
I
T
F
E
N
V
T
F
G
Y
-
H
P
D
-
R
K
-
I
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
Y
D
P
E
---
S
G
R
I
L
I
N
G
R
D
I
K
E
Y
D
I
D
A
L
R
K
V
I
G
V
V
P
Q
D
T
P
L
F
N
D
T
I
W
E
N
V
K
F
-
G
---
R
I
-
D
---
A
-
T
D
E
E
V
I
T
V
V
E
K
A
Q
L
A
P
L
---
I
K
K
L
P
Q
G
F
D
T
I
V
G
E
R
G
L
M
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
-----
A
L
L
R
T
I
----
R
--
D
N
F
TSGSR
T
S
--
V
Y
I
A
H
R
L
R
T
I
A
D
A
D
K
I
I
V
L
D
N
G
R
V
-------------------------
2
PsiBlast_PDB
72.79
29%
-107
- C1 -
4S0F
2
?
A:
[161-701]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
G
F
L
K
P
L
-
K
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
-
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
-----
K
F
---
E
K
--
L
---
N
D
L
H
---
I
I
S
A
G
F
A
V
I
---------
F
--
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
--
N
S
R
K
V
G
E
I
I
S
R
-
F
M
-
D
-
A
S
K
I
-
R
Q
A
---
I
S
G
A
T
L
T
I
M
I
D
T
I
M
--
A
-
V
I
G
G
I
L
L
-
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
---
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
--
G
M
L
Y
-
I
N
----
L
S
S
L
T
G
I
V
A
G
L
G
G
-------
I
---
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
A
T
E
K
E
L
R
E
---
D
------
S
D
D
F
V
I
S
L
K
G
D
----
I
E
F
R
N
V
D
F
R
Y
-
G
L
R
-
K
P
-
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
-
G
---
N
E
-
N
---
V
-
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
---
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
-
I
-
K
D
A
I
Y
G
L
----
E
DD
V
-------
T
V
--
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
-------------------------
113
HHSearch
72.59
25%
-106
- C1 -
3WMG
3
?
A:
[32-582]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
I
---
A
S
I
L
E
-
G
A
-
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
-----
K
S
---
K
S
Q
I
E
---
G
E
T
W
---
K
Y
S
V
G
F
V
G
I
---------
G
--
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
--
D
R
R
K
A
G
E
L
G
G
K
-
L
N
-
N
D
V
Q
V
I
-
Q
Y
S
---
F
S
K
-
L
G
A
V
L
F
N
L
A
Q
C
V
V
-
G
I
I
V
A
F
I
-
F
--
A
P
A
L
T
G
V
L
I
A
L
S
---
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
--
Y
I
S
D
-
G
L
----
F
F
G
L
S
M
L
V
I
F
C
V
Y
-------
A
---
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
P
Q
Y
R
R
P
D
---
P
G
A
E
V
V
T
Q
P
L
V
L
---
K
Q
G
----
I
V
F
E
N
V
H
F
R
Y
-
P
T
R
M
N
V
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
-
G
---
K
R
-
D
---
A
-
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
---
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
-
V
-
Q
E
A
L
D
R
M
M
A
SD
G
--
V
-------
T
S
--
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
-------------
110
HHSearch
72.38
22%
-108
- C1 -
3B60
2
MSBA_SALTY
A:
[15-571]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
-
A
G
I
---
A
L
I
L
N
-
A
A
-
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
-----
G
K
---
T
D
--
R
---
S
V
L
L
---
W
M
P
L
V
V
I
G
L
---------
M
--
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
--
D
K
Q
S
T
G
T
L
L
S
R
-
I
T
-
Y
D
S
E
Q
V
-
A
S
S
---
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
-
L
F
I
M
M
F
Y
-
Y
--
S
W
Q
L
S
I
I
L
V
V
L
A
---
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
--
V
S
A
S
-
S
I
----
S
D
P
I
I
Q
L
I
A
S
L
A
L
-------
A
---
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
---
R
------
V
I
D
R
A
---
T
G
D
----
L
E
F
R
N
V
T
F
T
Y
-
P
G
R
-
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
-
A
---
R
T
E
E
---
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
---
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
-
I
-
Q
A
A
L
D
E
L
Q
K
--
N
--
R
-------
T
S
--
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
----------
102
Fugue
72.05
21%
-105
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Q
--------------------------------------------------------------
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
-
I
V
A
G
I
---
A
L
I
L
N
-
A
A
-
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
-----
G
K
---
T
D
--
R
---
S
V
L
L
---
W
M
P
L
V
V
I
G
L
---------
M
--
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
--
D
K
Q
S
T
G
T
L
L
S
R
-
I
T
-
Y
D
S
E
Q
V
-
A
S
S
---
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
-
L
F
I
M
M
F
Y
-
Y
--
S
W
Q
L
S
I
I
L
V
V
L
A
---
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
--
V
S
A
S
-
S
I
----
S
D
P
I
I
Q
L
I
A
S
L
A
L
-------
A
---
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
---
R
------
V
I
D
R
A
T
---
G
D
----
L
E
F
R
N
V
T
F
T
Y
-
P
G
R
-
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
---
T
E
-
E
---
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
---
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
-
I
-
Q
A
A
L
D
E
L
----
Q
K
N
R
-------
T
S
--
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
QFG
109
Fugue
70.45
24%
-99
- C1 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
QE
I
S
W
F
D
T
N
HSGT
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
GD
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
NG
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
GSLN
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
LDRKPVIDSS
S
K
A
G
R
KDMKIK
G
D
I
T
V
E
N
V
H
F
T
Y
PSRPDVPILRG
M
N
L
R
V
N
AGQT
V
A
L
V
G
S
SGCG
K
S
T
I
I
S
L
L
L
RYYDVL
K
G
K
I
T
I
DGVDVRDIN
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
NCT
I
E
E
N
I
S
L
G
KEGIT
R
E
E
M
V
A
A
C
K
M
A
NA
E
K
F
I
K
T
L
PNGYNTLVGDR
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
----
R
N
P
K
I
L
L
L
D
E
A
T
S
A
LDAES
E
G
I
V
Q
Q
A
L
D
K
A
A
K
G
R
T
T
I
I
I
A
H
R
------
L
S
T
I
R
N
A
D
L
I
I
S
C
K
N
------
G
Q
V
V
E
V
G
D
H
R
A
-
L
M
A
Q
Q
------
G
----
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
G
E
R
I
----------
G
K
D
A
L
S
R
L
K
Q
E
L
E
E
N
N
A
Q
K
T
N
L
F
E
I
L
Y
H
A
R
P
H
A
L
S
L
F
I
-
G
M
S
T
A
---
T
I
G
G
F
--
I
-
Y
P
T
Y
S
V
F
F
T
S
F
M
--
N
V
F
-----
A
G
---
N
P
--
A
---
D
F
L
S
Q
G
H
F
W
A
L
M
F
L
V
L
---------
A
--
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
Q
H
I
G
F
F
DS
P
Q
N
A
S
G
K
I
S
T
R
-
L
A
T
D
-
V
P
N
L
-
R
T
A
---
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
-
G
I
G
L
A
F
F
-
Y
--
G
W
Q
M
A
L
L
I
I
A
I
L
---
P
I
V
A
F
G
Q
Y
L
R
G
R
R
F
T
G
K
N
V
K
S
A
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
A
R
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
--
A
F
I
Q
G
L
S
----
Y
G
C
A
S
S
V
L
Y
L
L
N
T
-------
C
---
A
Y
R
M
G
L
A
L
I
I
T
D
P
P
----
T
M
Q
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
T
L
G
F
A
T
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
K
I
S
K
---
I
------
D
S
L
S
L
A
G
E
K
K
K
LYGK
V
I
F
K
N
V
R
F
A
Y
-
P
E
R
P
E
I
E
I
L
K
G
L
S
F
S
V
E
P
G
Q
T
L
A
L
V
G
P
S
G
C
G
K
S
T
V
V
A
L
L
E
R
F
Y
D
T
L
---
G
G
E
I
F
I
D
G
S
E
I
K
T
L
N
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
D
C
S
I
A
E
N
I
I
Y
G
L
---
D
P
-
S
---
S
V
T
M
A
Q
V
E
E
A
A
R
L
A
N
I
H
N
F
---
I
A
E
L
P
E
G
F
E
T
R
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
-
V
-
Q
E
A
L
D
R
A
----
R
EG
R
-------
T
C
--
I
V
I
A
H
R
L
N
T
V
M
N
A
D
C
I
A
V
V
S
N
G
T
I
I
E
K
G
T
H
T
Q
L
M
S
E
K
------------
11
PsiBlast_PDB
69.53
27%
-103
- C1 -
4AYX
7
ABCBA_HUMAN
A:
[32-560]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
-
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
-----
T
N
PTV
D
Y
--
S
---
D
N
L
T
---
R
L
C
L
G
L
S
A
V
---------
F
--
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
--
D
K
T
R
T
G
E
L
I
N
R
-
L
S
-
S
-
D
T
A
L
L
G
R
S
---
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
-
G
I
S
M
M
F
F
-
V
--
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
-------
S
K
V
D
H
V
M
Q
L
--
A
R
K
E
-
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
-------
L
---
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
---
G
------
V
I
L
N
E
K
S
F
Q
G
A
----
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
-
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
-
G
---
A
D
-
D
---
P
-
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
-
V
-
Q
E
A
L
D
R
L
----
M
--
D
-------
G
R
TV
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
------------------------
13
PsiBlast_PDB
68.16
27%
-102
- C1 -
4AYW
3
ABCBA_HUMAN
A:
[63-591]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
-
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
-----
T
N
PTV
D
Y
--
S
---
D
N
L
T
---
R
L
C
L
G
L
S
A
V
---------
F
--
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
--
D
K
T
R
T
G
E
L
I
N
R
-
L
S
-
S
-
D
T
A
L
L
G
R
S
---
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
-
G
I
S
M
M
F
F
-
V
--
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
-------
S
K
V
D
H
V
M
Q
L
--
A
R
K
E
-
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
-------
L
---
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
---
G
------
V
I
L
N
E
K
S
F
Q
G
A
----
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
-
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
-
G
---
A
D
-
D
---
P
-
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
-
V
-
Q
E
A
L
D
R
L
----
M
--
D
-------
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
------------------------
12
PsiBlast_PDB
67.65
27%
-100
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[32-560]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
-
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
-----
T
N
PTV
D
Y
--
S
---
D
N
L
T
---
R
L
C
L
G
L
S
A
V
---------
F
--
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
--
D
K
T
R
T
G
E
L
I
N
R
-
L
S
-
S
-
D
T
A
L
L
G
R
S
---
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
-
G
I
S
M
M
F
F
-
V
--
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
-------
S
K
V
D
H
V
M
Q
L
--
A
R
K
E
-
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
-------
L
---
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
---
G
------
V
I
L
N
E
K
S
F
Q
G
A
----
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
-
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
-
G
---
A
D
-
D
---
P
-
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
-
V
-
Q
E
A
L
D
R
L
----
M
--
D
-------
G
R
TV
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
------------------------
10
PsiBlast_PDB
66.84
27%
-102
- C1 -
4AYT
8
ABCBA_HUMAN
A:
[32-560]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
-
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
-----
T
N
PTV
D
Y
--
S
---
D
N
L
T
---
R
L
C
L
G
L
S
A
V
---------
F
--
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
--
D
K
T
R
T
G
E
L
I
N
R
-
L
S
-
S
-
D
T
A
L
L
G
R
S
---
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
-
G
I
S
M
M
F
F
-
V
--
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
-------
S
K
V
D
H
V
M
Q
L
--
A
R
K
E
-
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
-------
L
---
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
---
G
------
V
I
L
N
E
K
S
F
Q
G
A
----
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
-
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
-
G
---
A
D
-
D
---
P
-
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
-
V
-
Q
E
A
L
D
R
L
----
M
--
D
-------
G
R
TV
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
------------------------
5
PsiBlast_PDB
62.45
27%
-109
- C1 -
4A82
-
Y1866_STAAM
A:
[14-568]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
I
F
-
A
T
I
I
V
-----
G
I
I
-
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
NNHAL
T
T
---
D
E
--
K
---
V
H
H
L
---
T
I
A
I
G
I
A
L
F
---------
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
--
A
N
N
Q
V
G
Q
V
I
S
R
----
V
-
I
N
D
V
-
E
Q
T
K
DF
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
-
A
L
S
I
M
F
F
-
L
--
D
V
K
L
T
L
A
A
L
F
I
F
---
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
-----
D
K
K
N
T
N
F
L
T
--
R
A
L
K
-------
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
---
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
----
V
------
G
A
Q
P
I
E
I
K
Q
G
R
----
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
-
G
---
R
P
-
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
---
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
-
I
-
Q
E
A
L
D
V
L
----
S
--
K
-------
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
----------
38
PsiBlast_CBE
59.67
41%
-112
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[1-215]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
36
PsiBlast_CBE
59.30
41%
-113
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[1-215]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
TV
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
37
PsiBlast_CBE
59.03
41%
-111
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[1-215]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
TV
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
21
PsiBlast_CBE
58.83
42%
-120
- C1 -
2PMK
1
A:
[3-217]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
120
HHSearch
58.71
40%
-108
- C1 -
2FF7
1
A:
[5-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
CK--
G
--
R
-------
T
V
--
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
------------
22
PsiBlast_CBE
58.59
42%
-114
- C1 -
2FF7
1
A:
[7-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
33
PsiBlast_CBE
58.27
41%
-108
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[7-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
27
PsiBlast_CBE
58.25
41%
-113
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[7-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
TV
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
35
PsiBlast_CBE
58.11
41%
-110
- C1 -
1XEF
3
D:
[1-215]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
TV
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
28
PsiBlast_CBE
58.05
41%
-108
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[7-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
25
PsiBlast_CBE
57.91
41%
-114
- C1 -
2FGK
2
D:
[7-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
TV
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
26
PsiBlast_CBE
57.64
41%
-108
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[7-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
TV
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
30
PsiBlast_CBE
57.55
41%
-111
- C1 -
2FGJ
2
D:
[7-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
TV
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
29
PsiBlast_CBE
57.42
41%
-114
- C1 -
2FFB
1
A:
[7-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
TV
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
24
PsiBlast_CBE
57.16
41%
-118
- C1 -
3B5J
1
A:
[3-217]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
TV
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
34
PsiBlast_CBE
56.90
41%
-114
- C1 -
2FFA
2
A:
[7-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
TV
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
31
PsiBlast_CBE
56.82
41%
-107
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[7-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
TV
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
32
PsiBlast_CBE
56.50
41%
-104
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[7-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
---
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
---
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
-
I
-
M
R
N
M
H
K
I
----
C
--
K
-------
G
R
TV
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
-------------------------
45
PsiBlast_CBE
55.95
38%
-102
- C1 -
3NH9
3
A:
[47-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
F
Q
K
G
R
----
I
E
F
E
N
V
H
F
S
Y
-
A
D
G
-
R
E
T
L
Q
D
-
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
-
G
---
R
V
-
T
---
A
-
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
---
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
-
I
-
Q
A
S
L
A
K
V
----
C
--
A
-------
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
-------------------------
117
HHSearch
55.91
32%
-102
* C1 *
3VX4
3
?
A:
[29-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
L
---
D
G
D
----
I
S
F
E
N
L
S
Y
K
Y
-
G
F
G
--
R
D
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
-
G
---
A
K
-
E
G--
T
-
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
---
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
-
I
-
I
S
N
L
L
Q
M
T---
E
--
K
-------
T
I
--
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
Q
G
F
----------
124
HHSearch
54.17
31%
-102
- C1 -
1MV5
3
LMRA_LACLA
A:
[2-228]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
-
D
D
S
--
E
Q
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
-
G
---
L
E
-
G
D--
Y
-
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
---
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
-
V
-
Q
K
A
L
D
S
L
M
K--
G
--
R
-------
T
T
--
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
H
------------
43
PsiBlast_CBE
54.02
38%
-104
- C1 -
3NHB
3
A:
[47-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
F
Q
K
G
R
----
I
E
F
E
N
V
H
F
S
Y
-
A
D
--
R
E
T
L
Q
D
-
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
-
G
---
R
V
-
T
---
A
-
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
---
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
-
I
-
Q
A
S
L
A
K
V
----
C
--
A
-------
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
-------------------------
44
PsiBlast_CBE
53.51
38%
-102
- C1 -
3NHA
4
A:
[47-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
F
Q
K
G
R
----
I
E
F
E
N
V
H
F
S
Y
-
A
D
--
R
E
T
L
Q
D
-
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
-
G
---
R
V
-
T
---
A
-
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
---
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
-
I
-
Q
A
S
L
A
K
V
----
C
--
A
-------
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
-------------------------
53
PsiBlast_CBE
53.22
33%
-95
- C1 -
3VX4
3
?
D:
[28-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
S
F
L
D
G
D
----
I
S
F
E
N
L
S
Y
K
Y
-
G
F
G
-
R
D
T
L
S
D
-
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
-
G
---
A
K
-
E
G--
T
-
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
---
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
-
S
N
L
L
Q
M
T
----
E
--
K
-------
T
I
--
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
-------------------------
54
PsiBlast_CBE
51.96
33%
-96
- C1 -
3VX4
3
?
A:
[29-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
L
D
G
D
----
I
S
F
E
N
L
S
Y
K
Y
-
G
F
G
-
R
D
T
L
S
D
-
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
-
G
---
A
K
-
E
G--
T
-
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
---
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
-
S
N
L
L
Q
M
T
----
E
--
K
-------
T
I
--
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
-------------------------
84
PsiBlast_CBE
45.47
31%
-95
- C1 -
1R0X
4
D:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
56
PsiBlast_CBE
45.46
35%
-90
- C1 -
1MV5
1
LMRA_LACLA
C:
[31-216]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
-
G
LEG
D
Y
-
T
---
D
-
E
D
L
W
--
Q
V
L
D
L
A
F
A
R
S
F
---
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
-
V
-
Q
K
A
L
D
S
L
----
M
--
K
GR-----
T
T
--
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
------------------------
58
PsiBlast_CBE
44.27
35%
-87
- C1 -
1MV5
2
LMRA_LACLA
A:
[31-216]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
-
G
LEG
D
Y
-
T
---
D
-
E
D
L
W
--
Q
V
L
D
L
A
F
A
R
S
F
---
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
-
V
-
Q
K
A
L
D
S
L
----
M
--
K
G
R
-----
T
T
--
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
------------------------
85
PsiBlast_CBE
43.99
31%
-93
- C1 -
1R0X
3
CFTR_MOUSE
C:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
81
PsiBlast_CBE
43.95
31%
-91
- C1 -
1R0Y
2
CFTR_MOUSE
C:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
86
PsiBlast_CBE
43.94
31%
-92
- C1 -
1R0X
3
CFTR_MOUSE
B:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
80
PsiBlast_CBE
43.89
31%
-97
- C1 -
1R0Y
3
D:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
97
PsiBlast_CBE
43.88
31%
-94
- C1 -
3SI7
7
CFTR_MOUSE
C:
[53-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
---
I
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
82
PsiBlast_CBE
43.66
31%
-91
- C1 -
1R0Y
2
CFTR_MOUSE
B:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
92
PsiBlast_CBE
43.30
31%
-94
- C1 -
1Q3H
3
D:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
95
PsiBlast_CBE
43.29
31%
-92
- C1 -
1Q3H
4
CFTR_MOUSE
A:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
96
PsiBlast_CBE
43.14
31%
-93
- C1 -
3SI7
6
D:
[53-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
---
I
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
99
PsiBlast_CBE
43.12
31%
-95
- C1 -
3SI7
6
CFTR_MOUSE
A:
[53-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
---
I
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
93
PsiBlast_CBE
43.00
31%
-94
- C1 -
1Q3H
3
CFTR_MOUSE
C:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
98
PsiBlast_CBE
42.87
31%
-92
- C1 -
3SI7
4
CFTR_MOUSE
B:
[53-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
---
I
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
75
PsiBlast_CBE
42.87
31%
-91
- C1 -
1R0Z
3
CFTR_MOUSE
C:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
83
PsiBlast_CBE
42.53
31%
-92
- C1 -
1R0Y
4
CFTR_MOUSE
A:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
87
PsiBlast_CBE
42.46
31%
-93
- C1 -
1R0X
5
CFTR_MOUSE
A:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
77
PsiBlast_CBE
42.46
31%
-90
- C1 -
1R0Z
4
CFTR_MOUSE
A:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
74
PsiBlast_CBE
42.28
31%
-92
- C1 -
1R0Z
3
D:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
78
PsiBlast_CBE
42.00
31%
-93
- C1 -
1R10
3
B:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
76
PsiBlast_CBE
41.76
31%
-89
- C1 -
1R0Z
3
CFTR_MOUSE
B:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
79
PsiBlast_CBE
41.52
31%
-92
- C1 -
1R10
5
CFTR_MOUSE
A:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
94
PsiBlast_CBE
41.48
31%
-90
- C1 -
1Q3H
3
CFTR_MOUSE
B:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
F
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
100
PsiBlast_CBE
41.38
31%
-94
- C1 -
1XF9
5
D:
[53-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
I
I
K
H
S
G
R
-------------
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-
I
-
S
---
G
V
-
S
---
Y
-
D
E
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
---
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
-
V
F
E
S
C
V
C
K
L
MA--
N
--
K
-------
T
R
--
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
---------------------------
57
PsiBlast_CBE
39.78
35%
-75
- C1 -
1MV5
1
LMRA_LACLA
B:
[31-216]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
-
G
LEG
D
Y
-
T
---
D
-
E
D
L
W
--
Q
V
L
D
L
A
F
A
R
S
F
---
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
-
V
-
Q
K
A
L
D
S
L
----
M
--
K
GR-----
T
T
--
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
------------------------
55
PsiBlast_CBE
38.79
35%
-80
- C1 -
1MV5
2
D:
[31-216]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
-
G
LEG
D
Y
-
T
---
D
-
E
D
L
W
--
Q
V
L
D
L
A
F
A
R
S
F
---
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
-
V
-
Q
K
A
L
D
S
L
----
M
--
K
GR-----
T
T
--
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
------------------------