@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4158: (2016-02-24 )
MTHRLHADAVTLRRDARTVSRNLSLAIPEGSFSVIVGPNACGKSTLLAALSRLLAPAEGRVVLDGRDIHSLPGREVARRLGLLPQSALAPDGITVAELVARGRYPHQSFLRQWSPADERAVAAALRATRVDGLAERPLDALSGGQRQRVWIAMVLAQETPLLLLDEPTTYLDIVHQIELLELLAELNRQGRTIVAVLHDLNQACRYASHLIAMRDGAILAEGAPAHIFTERLVEEVFGLRSLIIADPVSGTPLLVPRGIAADAPG
Atome Classification :
(41 SA)
--.........10....-.----...20........30........40........50........60....-----...-.70-.-------------..---.---.----...----.80.-....-.------.-.90----.........100-.......--110..-...-.----.120.........130.----.-.-.----..---.140.......150....-----...160........170----.......180.......-190-........200.......210.......220......---.230.......240.......250.----------------......260...---------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MTHRLHA
D
A
V
T
L
R
R
D
-
A
----
R
T
V
SRN
L
S
L
A
IPEG
S
F
S
V
I
VGPNAC
G
K
S
T
L
L
A
A
L
S
R
L
LAPAE
G
R
V
V
LDG-----RDI-HS--L-------------
P
G
---
R
---
E
----
V
A
R
----
R
LGL-LPQS-A------L-AP-----DG
I
T
V
A
E
L
V
ARG-RYP
H
Q
S
F
--
L
R
QWS-P
A
D
-
E
----
R
A
--
V
A
A
A
L
R
A
T
R
VD
G
L
----
A
-E-R----P
L
---
D
A
LSGGQ
R
Q
R
V
W
I
A
M
V
LA-----QET
P
-
L
L
L
LDEP
T
T
Y
L
D
----
I
V
H
Q
I
E
L
L
E
L
L
A
E
L
NRQ-G-
R
-
T
I
V
A
V
L
H
D
L
N
Q
A
C
R
Y
A
S
H
L
I
A
MRD
G
A
I
LAEGA
P
A
H
I
F
---
T
E
R
L
V
E
E
V
F
G
L
R
S
L
I
IADPVSGT
P
L
----------------
L
V
PRGIAADAPG---------------------------------------------------------------------------------
1
PsiBlast_PDB
91.00
33%
-142
- C1 -
4G1U
1
HMUV_YERPE
C:
[28-265]
---------------------------
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
E
C
H
L
L
G
-----
Q
N
L
-
N
S
--
W
-------------
Q
P
---
K
---
A
----
L
A
R
----
T
R
A
V
-
M
R
Q
Y
-
S
------
E
-
L
A
-----
F
P
F
S
V
S
E
V
I
Q
M
G
-
R
A
P
Y
G
--------
G
-
S
Q
D
-
R
----
Q
A
--
L
Q
Q
V
M
A
Q
T
D
C
L
A
L
----
A
-
Q
-
R
----
D
Y
---
R
V
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
L
WQP
Q
P
T
P
R
W
L
F
L
D
E
P
T
S
A
L
D
----
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
Q
-
E
P
L
-
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
A
Q
G
K
L
V
A
C
G
T
P
E
E
V
L
---
N
A
E
T
L
T
Q
W
Y
Q
A
D
L
G
V
S
R
H
P
E
S
A
L
P
Q
----------------
I
Y
L
R
-----------------------------------------------------------------------------------------
21
PsiBlast_CBE
90.80
33%
-142
- C1 -
4G1U
1
HMUV_YERPE
D:
[28-265]
---------------------------
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
E
C
H
L
L
G
-----
Q
N
L
-
N
S
--
W
-------------
Q
P
---
K
---
A
----
L
A
R
----
T
R
A
V
-
M
R
Q
Y
-
S
------
E
-
L
A
-----
F
P
F
S
V
S
E
V
I
Q
M
G
-
R
A
P
Y
G
--------
G
-
S
Q
D
-
R
----
Q
A
--
L
Q
Q
V
M
A
Q
T
D
C
L
A
L
----
A
-
Q
-
R
----
D
Y
---
R
V
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
QLWQP
Q
P
T
P
R
W
L
F
L
D
E
P
T
S
A
L
D
----
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
Q
-
E
P
L
-
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
A
Q
G
K
L
V
A
C
G
T
P
E
E
V
L
---
N
A
E
T
L
T
Q
W
Y
Q
A
D
L
G
V
S
R
H
P
E
S
A
L
P
Q
----------------
I
Y
L
R
-----------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.07
32%
-114
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[25-244]
---------------------------
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
-----
K
P
I
D
Y
S
--
R
-------------
K
G
I
--
M
---
K
----
L
R
E
----
S
I
G
I
-
V
F
Q
D
-----------
P
-----
D
N
----
Q
L
F
S
A
S
-
V
Y
Q
D
V
S
F
G
A
V
N
M
K
L
-
P
E
D
-
E
I
R
--
K
R
--
V
D
N
A
L
K
R
T
G
I
E
H
L
----
K
-
D
-
K
----
P
T
---
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
-----
M
E
P
K
-
V
L
I
L
D
E
P
T
A
G
L
D
----
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
-
I
-
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
---
A
E
K
E
V
I
R
K
V
N
L
R
--------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.80
35%
-129
- C1 -
2IT1
1
?
B:
[17-222]
------------------------
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
-----
K
D
V
-
T
E
--
L
-------------
P
P
---
K
---
D
------
R
----
N
V
G
L
-
V
F
Q
N
W
A
------
L
-
Y
P
-----
H
-
M
T
V
Y
K
N
I
A
----
F
P
L
E
----
L
R
K
-
A
-
P
R
E
-
E
I
D
--
K
K
--
V
R
E
V
A
K
M
L
H
I
D
K
L
----
L
-
N
-
R
----
Y
P
---
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
-----
K
E
P
E
-
V
L
L
L
D
E
P
L
S
N
L
D
----
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
-
I
-
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------
89
HHSearch
76.40
28%
-118
* C1 *
3TUI
1
METN_ECOLI
C:
[23-255]
----
H
M
I
K
L
S
N
I
T
K
V
F
H
-
Q
GTRT
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
-----
Q
E
L
-
T
T
--
L
-------------
S
E
---
S
ELT
K
----
A
R
R
----
Q
I
G
M
-
I
F
Q
H
-
F
------
N
-
L
L
-----
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
------
P
K
-
D
E
V
-
K
----
R
R
--
V
T
E
L
L
S
L
V
G
L
G
D
K
----
H
-
D
-
S
----
Y
P
---
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
-----
S
N
P
K
-
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
-
L
-
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
---
S
H
P
-----------------------------------------------------------------------------------------------------------------------------------
100
HHSearch
76.36
31%
-111
- C1 -
1B0U
4
HISP_SALTY
A:
[5-245]
----
N
K
L
H
V
I
D
L
H
K
R
Y
G
-
G
----
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
-----
Q
N
I
-
N
L
--
V
R
D
KDGQLKVAD
K
N
Q
L
---
R
---
L
----
L
R
T
----
R
L
T
M
-
V
F
Q
H
-
F
------
N
-
L
W
-----
S
H
M
T
V
L
E
N
V
M
E
A
-
P
I
Q
V
L
G
-----
L
S
K
-
H
D
A
-
R
----
E
R
--
A
L
K
Y
L
A
K
V
G
I
D
E
R
----
A
Q
G
-
K
----
Y
P
---
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
-----
M
E
P
D
-
V
L
L
F
D
E
P
T
S
A
L
D
----
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
-
G
-
K
-
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
---
G
N
P
Q
----------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
76.21
28%
-116
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[5-246]
---
D
Y
I
L
K
V
E
E
L
N
Y
N
Y
S
-
D
G---
T
H
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
-----
K
P
I
-
D
Y
--
S
R
K
-----------
G
I
---
M
---
K
----
L
R
E
----
S
I
G
I
-
V
F
Q
D
-
P
------
D
N
Q
L
-----
F
S
A
S
V
Y
Q
D
V
S
F
G
-
A
V
N
M
K
L
------
P
E
-
D
E
I
-
R
----
K
R
--
V
D
N
A
L
K
R
T
G
I
E
H
L
----
K
-
D
-
K
----
P
T
---
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
-----
M
E
P
K
-
V
L
I
L
D
E
P
T
A
G
L
D
----
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
-
I
-
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
---
A
E
K
E
V
I
R
K
V
N
L
R
L
P
------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.85
35%
-127
- C1 -
2IT1
-
?
A:
[17-222]
------------------------
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
-----
K
D
V
-
T
E
--
L
-------------
P
P
---
K
---
D
------
R
----
N
V
G
L
-
V
F
Q
N
W
A
------
L
-
Y
P
-----
H
-
M
T
V
Y
K
N
I
A
----
F
P
L
E
----
L
R
K
-
A
-
P
R
E
-
E
I
D
--
K
K
--
V
R
E
V
A
K
M
L
H
I
D
K
L
----
L
-
N
-
R
----
Y
P
---
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
-----
K
E
P
E
-
V
L
L
L
D
E
P
L
S
N
L
D
----
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
-
I
-
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------
87
HHSearch
74.13
29%
-120
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-226]
----
A
S
V
Q
L
Q
N
V
T
K
A
W
G
-
E
----
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
-----
K
R
M
-
N
D
--
T
-------------
P
--------
P
----
A
E
R
----
G
V
G
M
-
V
F
Q
S
-
Y
------
A
-
L
Y
-----
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
------
A
K
K
-
E
V
I
-
N
----
Q
R
--
V
N
Q
V
A
E
V
L
Q
L
A
H
L
----
L
-
D
-
R
----
K
P
---
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
-----
A
E
P
S
-
V
F
L
L
D
E
P
L
S
N
L
D
----
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
-
R
-
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
---
H
Y
P
A
----------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
73.68
31%
-127
- C1 -
1Z47
1
?
A:
[28-236]
------------------
A
----
R
S
V
-
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
-----
K
R
V
-
T
D
--
L
-------------
P
P
---
Q
---
K
------
R
----
N
V
G
L
-
V
F
Q
N
-
Y
------
A
-
L
F
-----
Q
H
M
T
V
Y
D
N
V
S
F
G
----------
L
R
E
K
R
V
P
K
D
-
E
----
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
----
A
-
N
-
R
----
F
P
---
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
-----
P
R
P
Q
-
V
L
L
F
D
E
P
F
A
A
I
D
----
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
-
V
-
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
---
E
K
------------------------------------------------------------------------------------------------------------------------------------
106
Fugue
73.36
24%
-113
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
HM
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
----
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
-----
Q
E
L
-
T
T
--
L
-------------
S
E
SEL
T
---
K
----
A
R
R
----
Q
I
G
M
-
I
F
Q
H
-
F
------
N
-
L
L
-----
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
------
N
T
P
K
-
D
E
V
-
K
----
R
R
--
V
T
E
L
L
S
L
V
G
L
G
D
K
----
H
-
D
-
S
----
Y
P
---
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
-----
S
N
P
K
-
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
-
L
-
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
---
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
ERLQAEPFTDCVPMLR
L
E
F
T
G
Q
S
V
D
A
P
L
LSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV------------------------
72
PsiBlast_CBE
72.97
31%
-124
- C1 -
4HLU
3
ECFA1_THEMA
C:
[11-234]
-----
R
I
E
L
N
S
V
S
F
R
Y
N
-
G
----
D
Y
V
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
A
A
A
-
G
E
I
F
L
D
G
-----
S
P
A
-
D
P
--
F
-------------
L
L
---
R
---
K
----
N
V
G
----
Y
V
F
Q
-
N
P
S
S
-
Q
------
I
-
I
-------
G
A
T
V
E
E
D
V
A
---------
F
--
S
L
E
I
M
-
G
L
D
-
E
SEMR
K
R
--
I
K
K
V
L
E
L
V
G
L
S
G
L
----
A
-
A
A
D
----
P
L
---
N
-
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
-----
R
D
T
R
-
F
L
A
L
D
E
P
V
S
M
L
D
----
P
P
S
Q
R
E
I
F
Q
V
L
E
S
L
K
N
E
-
G
-
K
-
G
I
I
L
V
T
H
E
L
-
E
Y
L
D
D
M
D
F
I
L
H
I
S
N
G
T
I
D
F
C
G
S
W
E
E
-
F
---
V
E
R
E
F
D
D
V
------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
72.78
31%
-124
- C1 -
1Z47
1
?
B:
[28-236]
------------------
A
----
R
S
V
-
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
-----
K
R
V
-
T
D
--
L
-------------
P
P
---
Q
---
K
------
R
----
N
V
G
L
-
V
F
Q
N
-
Y
------
A
-
L
F
-----
Q
H
M
T
V
Y
D
N
V
S
F
G
----------
L
R
E
K
R
V
P
K
D
-
E
----
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
----
A
-
N
-
R
----
F
P
---
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
-----
P
R
P
Q
-
V
L
L
F
D
E
P
F
A
A
I
D
----
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
-
V
-
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
---
E
K
------------------------------------------------------------------------------------------------------------------------------------
111
Fugue
71.71
26%
-114
- C1 -
1Z47
1
?
A:
[11-355]
--
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
----
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
-----
K
R
V
-
T
D
--
L
-------------
P
P
---
Q
---
K
------
R
----
N
V
G
L
-
V
F
Q
N
-
Y
------
A
-
L
F
-----
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
------
R
V
P
K
-
D
E
M
-
D
----
A
R
--
V
R
E
L
L
R
F
M
R
L
E
S
Y
----
A
-
N
-
R
----
F
P
---
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
-----
P
R
P
Q
-
V
L
L
F
D
E
P
F
A
A
I
D
----
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
-
V
-
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
EKP
G
T
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
----------------
V
A
G
A
A
L
P
V
D
P
A
V
SEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
19
PsiBlast_PDB
71.15
30%
-128
- C1 -
1VCI
1
?
A:
[16-237]
---------
E
N
L
T
K
R
F
G
-
N
----
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
-----
R
D
V
-
T
Y
--
L
-------------
P
P
---
K
---
D
------
R
----
N
I
S
M
-
V
F
Q
-------------------
H
M
T
V
Y
E
N
I
A
----
F
P
L
------
K
K
F
--
P
K
D
-
E
I
D
--
K
R
--
V
R
W
A
A
E
L
L
Q
I
E
E
L
----
L
-
N
-
R
----
Y
P
---
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
-----
V
E
P
D
-
V
L
L
M
D
E
P
L
S
N
L
D
----
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
-
L
-
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
70.05
31%
-141
- C1 -
2YYZ
3
?
A:
[22-222]
-----------------------------
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
-----
V
L
V
-
N
D
--
I
-------------
P
P
---
K
---------
Y
R
----
E
V
G
M
-
V
F
Q
N
Y
A
------
L
-
Y
P
-----
H
-
M
T
V
F
E
N
I
A
----
F
P
L
R
A
----
R
R
I
S
-
K
D
E
V
E
----
K
R
--
V
V
E
I
A
R
K
L
L
I
D
N
L
----
L
-
D
-
R
----
K
P
---
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
-----
K
Q
P
K
-
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
----
G
-
I
-
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
69.52
28%
-112
- C1 -
3D31
-
?
A:
[2-220]
------
I
E
I
E
S
L
S
R
K
W
K
-
N
-----
F
S
L
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
G
R
I
L
L
D
G
-----
K
D
V
-
T
D
--
L
-------------
S
P
------------
E
K
H
----
D
I
A
F
-
V
Y
Q
N
-
Y
------
S
-
L
F
-----
P
H
M
N
V
K
K
N
L
E
F
G
-
M
R
M
K
K
----------
I
K
D
-
P
----
K
R
--
V
L
D
T
A
R
D
L
K
I
E
H
L
----
L
-
D
-
R
----
N
P
---
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
-----
T
N
P
K
-
I
L
L
L
D
E
P
L
S
A
L
D
----
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
K
N
K
-
L
-
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
F
---
E
K
P
V
----------------------------------------------------------------------------------------------------------------------------------
84
HHSearch
69.29
30%
-111
- C1 -
2IT1
-
?
A:
[2-225]
----
V
E
I
K
L
E
N
I
V
K
K
F
G
-
N
----
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
-----
K
D
V
-
T
E
--
L
-------------
P
P
------------
K
D
R
----
N
V
G
L
-
V
F
Q
N
-
W
------
A
-
L
Y
-----
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
E
L
R
K
------
A
P
R
-
E
E
I
-
D
----
K
K
--
V
R
E
V
A
K
M
L
H
I
D
K
L
----
L
-
N
-
R
----
Y
P
---
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
-----
K
E
P
E
-
V
L
L
L
D
E
P
L
S
N
L
D
----
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
-
I
-
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
---
Y
K
P
-----------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.13
30%
-126
- C1 -
1V43
-
?
A:
[16-237]
---------
E
N
L
T
K
R
F
G
-
N
----
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
-----
R
D
V
-
T
Y
--
L
-------------
P
P
---
K
---
D
------
R
----
N
I
S
M
-
V
F
Q
-------------------
H
M
T
V
Y
E
N
I
A
----
F
P
L
------
K
K
F
--
P
K
D
-
E
I
D
--
K
R
--
V
R
W
A
A
E
L
L
Q
I
E
E
L
----
L
-
N
-
R
----
Y
P
---
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
-----
V
E
P
D
-
V
L
L
M
D
E
P
L
S
N
L
D
----
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
-
L
-
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
68.97
34%
-121
- C1 -
1L2T
4
Y796_METJA
B:
[22-226]
---------------------------
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-----
I
K
T
-
N
D
--
L
-------------
D
D
---
D
---
E
----
L
T
K
IRRD
K
I
G
F
-
V
F
Q
Q
-
F
------
N
-
L
I
-----
P
L
L
T
A
L
E
N
V
----
E
L
P
L
I
F
K
--
Y
R
G
A
M
-
S
G
E
-
E
----
R
R
---
K
R
A
L
E
C
L
K
M
A
E
L
----
E
-
E
-
R
FANH
K
P
---
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
-----
N
N
P
P
-
I
I
L
A
D
Q
P
T
G
A
L
D
----
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
-
K
-
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
68.58
32%
-118
- C1 -
3C4J
4
?
B:
[39-247]
-------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
-
N
L
--
N
-------------
K
V
---
R
---
E
EVGM
V
F
Q
----
R
F
N
L
-
F
P
H
M
-
T
------
V
-
L
------
N
N
I
T
L
A
P
M
K
V
R
--
K
W
P
R
---------------
E
----
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
-
D
-
K
----
A
H
AYP
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
-----
M
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
68.13
34%
-124
- C1 -
3TIF
6
Y796_METJA
B:
[22-226]
---------------------------
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-----
I
K
T
-
N
D
--
L
-------------
D
D
---
D
---
E
----
L
T
K
IRRD
K
I
G
F
-
V
F
Q
Q
-
F
------
N
-
L
I
-----
P
L
L
T
A
L
E
N
V
----
E
L
P
L
I
F
K
--
Y
R
G
A
M
-
S
G
E
-
E
----
R
R
---
K
R
A
L
E
C
L
K
M
A
E
L
----
E
-
E
-
R
FANH
K
P
---
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
-----
N
N
P
P
-
I
I
L
A
D
Q
P
T
W
A
L
D
----
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
-
K
-
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
68.11
34%
-119
- C1 -
1L2T
4
Y796_METJA
A:
[22-226]
---------------------------
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-----
I
K
T
-
N
D
--
L
-------------
D
D
---
D
---
E
----
L
T
K
I
R
R
D
K
I
G
F
-
V
F
Q
Q
-
F
------
N
-
L
I
-----
P
L
L
T
A
L
E
N
V
----
E
L
P
L
I
F
K
--
Y
R
G
A
M
-
S
G
E
-
E
----
R
R
---
K
R
A
L
E
C
L
K
M
A
E
L
----
E
-
E
-
R
FANH
K
P
---
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
-----
N
N
P
P
-
I
I
L
A
D
Q
P
T
G
A
L
D
----
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
-
K
-
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
66.73
32%
-112
- C1 -
2OLK
1
?
C:
[39-247]
-------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
-
N
L
--
N
-------------
K
V
---
R
---
E
EVGM
V
F
Q
----
R
F
N
L
-
F
P
H
M
-
T
------
V
-
L
------
N
N
I
T
L
A
P
M
K
V
R
--
K
W
P
R
---------------
E
----
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
-
D
-
K
----
A
H
AYP
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
-----
M
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
66.70
32%
-113
- C1 -
2OLK
1
?
A:
[39-247]
-------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
-
N
L
--
N
-------------
K
V
---
R
---
E
E
V
G
M
V
F
Q
----
R
F
N
L
-
F
P
H
M
-
T
------
V
-
L
------
N
N
I
T
L
A
P
M
K
V
R
--
K
W
P
R
---------------
E
----
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
-
D
-
K
----
A
H
AYP
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
-----
M
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
66.64
32%
-113
- C1 -
3C41
3
?
K:
[18-226]
-------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
-
N
L
--
N
-------------
K
V
---
R
---
E
EVGM
V
F
Q
----
R
F
N
L
-
F
P
H
M
-
T
------
V
-
L
------
N
N
I
T
L
A
P
M
K
V
R
--
K
W
P
R
---------------
E
----
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
-
D
-
K
----
A
H
AYP
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
-----
M
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
66.58
32%
-112
- C1 -
2OLK
1
?
D:
[39-247]
-------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
-
N
L
--
N
-------------
K
V
---
R
---
E
EVGM
V
F
Q
----
R
F
N
L
-
F
P
H
M
-
T
------
V
-
L
------
N
N
I
T
L
A
P
M
K
V
R
--
K
W
P
R
---------------
E
----
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
-
D
-
K
----
A
H
AYP
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
-----
M
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
66.57
34%
-118
- C1 -
3TIF
7
Y796_METJA
A:
[22-226]
---------------------------
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-----
I
K
T
-
N
D
--
L
-------------
D
D
---
D
---
E
----
L
T
K
I
R
R
D
K
I
G
F
-
V
F
Q
Q
-
F
------
N
-
L
I
-----
P
L
L
T
A
L
E
N
V
----
E
L
P
L
I
F
K
--
Y
R
G
A
M
-
S
G
E
-
E
----
R
R
---
K
R
A
L
E
C
L
K
M
A
E
L
----
E
-
E
-
R
FANH
K
P
---
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
-----
N
N
P
P
-
I
I
L
A
D
Q
P
T
W
A
L
D
----
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
-
K
-
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.56
32%
-111
- C1 -
2Q0H
4
?
A:
[39-247]
-------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
-
N
L
--
N
-------------
K
V
---
R
---
E
E
V
G
M
V
F
Q
----
R
F
N
L
-
F
P
H
M
-
T
------
V
-
L
------
N
N
I
T
L
A
P
M
K
V
R
--
K
W
P
R
---------------
E
----
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
-
D
-
K
----
A
H
AYP
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
-----
M
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
66.55
32%
-112
- C1 -
2OLJ
4
?
A:
[39-247]
-------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
-
N
L
--
N
-------------
K
V
---
R
---
E
E
V
G
M
V
F
Q
----
R
F
N
L
-
F
P
H
M
-
T
------
V
-
L
------
N
N
I
T
L
A
P
M
K
V
R
--
K
W
P
R
---------------
E
----
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
-
D
-
K
----
A
H
AYP
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
-----
M
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
65.55
32%
-112
- C1 -
2OLK
2
?
B:
[39-247]
-------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
-
N
L
--
N
-------------
K
V
---
R
---
E
EVGM
V
F
Q
----
R
F
N
L
-
F
P
H
M
-
T
------
V
-
L
------
N
N
I
T
L
A
P
M
K
V
R
--
K
W
P
R
---------------
E
----
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
-
D
-
K
----
A
H
AYP
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
-----
M
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
65.38
32%
-111
- C1 -
2Q0H
4
?
B:
[39-247]
-------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
-
N
L
--
N
-------------
K
V
---
R
---
E
E
V
G
M
V
F
Q
----
R
F
N
L
-
F
P
H
M
-
T
------
V
-
L
------
N
N
I
T
L
A
P
M
K
V
R
--
K
W
P
R
---------------
E
----
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
-
D
-
K
----
A
H
AYP
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
-----
M
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
65.09
32%
-107
- C1 -
3C41
3
?
J:
[18-226]
-------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
-
N
L
--
N
-------------
K
V
---
R
---
E
EVGM
V
F
Q
----
R
F
N
L
-
F
P
H
M
-
T
------
V
-
L
------
N
N
I
T
L
A
P
M
K
V
R
--
K
W
P
R
---------------
E
----
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
-
D
-
K
----
A
H
AYP
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
-----
M
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
64.38
32%
-109
- C1 -
3C4J
3
?
A:
[39-247]
-------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
-
N
L
--
N
-------------
K
V
---
R
---
E
E
V
G
M
V
F
Q
----
R
F
N
L
-
F
P
H
M
-
T
------
V
-
L
------
N
N
I
T
L
A
P
M
K
V
R
--
K
W
P
R
---------------
E
----
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
-
D
-
K
----
A
H
AYP
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
-----
M
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
63.70
32%
-111
- C1 -
4YMU
2
?
A:
[16-224]
-------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-----
V
K
I
-
N
N
GK
V
-------------
N
I
---
N
---
K
----
V
R
Q
----
K
V
G
M
-
V
F
Q
H
-
F
NLFPHL
T
-
A
I
-----
E
N
I
T
L
A
---------
P
V
K
V
K
--
K
M
N
K
K
-
E
A
E
-
E
----
L
A
--
V
D
L
L
A
K
V
G
L
L
D
K
K
----
D
-
Q
-
Y
----
P
I
----
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
-----
M
Q
P
E
-
V
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-----------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
63.23
35%
-104
- C1 -
4U00
3
?
A:
[19-227]
-------------------------
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
LSV--
K
D
D
-
R
A
--
L
------------------
R
---
E
----
I
R
R
----
E
V
G
M
V
F
Q
Q
F
-
N
------
L
-
F
P
HMT
V
L
E
N
V
T
L
A
P
M
R
V
R
--
R
W
P
R
E
K
----------
A
E
-
K
----
K
A
--
L
E
L
L
E
R
V
G
I
L
D
Q
A
----
R
-
K
-
Y
----
P
A
---
Q
-
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
-----
M
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
---
T
-------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
63.17
32%
-106
- C1 -
2OLJ
3
?
B:
[39-247]
-------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
-
N
L
--
N
-------------
K
V
---
R
---
E
EVGM
V
F
Q
----
R
F
N
L
-
F
P
H
M
-
T
------
V
-
L
------
N
N
I
T
L
A
P
M
K
V
R
--
K
W
P
R
---------------
E
----
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
-
D
-
K
----
A
H
AYP
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
-----
M
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
62.99
31%
-103
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[359-571]
-------------------------
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
-----
H
D
I
-
R
Q
--
L
-------------
N
P
---
V
---
W
----
L
R
S
----
K
I
G
T
-
V
S
Q
E
-
P
------
I
-
L
F
-----
S
-
C
S
I
A
E
N
I
A
Y
G
A
D
D
P
S
S
V
T
--
A
E
E
I
Q
-
R
V
A
-
E
----
V
A
--
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
-
E
-
K
----
G
V
----
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
-----
K
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
----
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
-
M
D
-
G
-
R
-
T
V
L
V
I
A
H
R
L
S
-
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
---
S
K
------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.88
32%
-109
- C1 -
4YMU
2
?
J:
[16-224]
-------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-----
V
K
I
-
N
N
GK
V
-------------
N
I
---
N
---
K
----
V
R
Q
----
K
V
G
M
-
V
F
Q
H
-
F
NLFPHL
T
-
A
I
-----
E
N
I
T
L
A
---------
P
V
K
V
K
--
K
M
N
K
K
-
E
A
E
-
E
----
L
A
--
V
D
L
L
A
K
V
G
L
L
D
K
K
----
D
-
Q
-
Y
----
P
I
----
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
-----
M
Q
P
E
-
V
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-----------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
62.69
32%
-110
- C1 -
4YMV
1
?
A:
[16-224]
-------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-----
V
K
I
-
N
N
GK
V
-------------
N
I
---
N
---
K
----
V
R
Q
----
K
V
G
M
-
V
F
Q
H
-
F
NLFPHL
T
-
A
I
-----
E
N
I
T
L
A
---------
P
V
K
V
K
--
K
M
N
K
K
-
E
A
E
-
E
----
L
A
--
V
D
L
L
A
K
V
G
L
L
D
K
K
----
D
-
Q
-
Y
----
P
I
----
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
-----
M
Q
P
E
-
V
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-----------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.47
32%
-110
- C1 -
4YMV
1
?
J:
[16-224]
-------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-----
V
K
I
-
N
N
GK
V
-------------
N
I
---
N
---
K
----
V
R
Q
----
K
V
G
M
-
V
F
Q
H
-
F
NLFPHL
T
-
A
I
-----
E
N
I
T
L
A
---------
P
V
K
V
K
--
K
M
N
K
K
-
E
A
E
-
E
----
L
A
--
V
D
L
L
A
K
V
G
L
L
D
K
K
----
D
-
Q
-
Y
----
P
I
----
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
-----
M
Q
P
E
-
V
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-----------------------------------------------------------------------------------------------------------------------------------------