@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4167: (2016-02-24 )
MSSTIHPLPSFGLGTFRLTGQVVVDSVRSALELGYRAIDTAQIYGNEADIGRAIAESGVPRSELFLTTKVWVDNYAREKLLASLRESLEKLRTDRLDLVLIHWPAPGNGVELGEYMAALAEAKSLGLTRRIGVSNFNIELTRQAIAAVGAGEISTNQIELSPYLQNRALTAYLEEQGIAVTSYMTLAYGKVLKDPTLAGIAARHRATVAQVALAWAMQLGYAVIPSSTRRENLASNLLARDLRLDAEDMARIAGLERNGREVSPQGLAPAWD
Atome Classification :
(82 SA)
......---...10.......-.-20.........30........40........50...----.----..-----..60........70........80........90........100..-----------------.---------..--------------.------------.--------110---........---.120.......130....------...140..--.....150...--.....160.......170.......180.....-----..--190--------..-------.......200.......210.......-220.......230.....-...240.......250.....-.-.260..-......270
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSTIH---PLPSFGLG
T
F
R
L
-T-
G
-
Q
V
V
V
D
S
V
R
S
A
L
E
L
G
Y
R
AI
D
T
A
Q
IYGN
E
A
D
I
G
R
A
I
----
A
----ES-----GVPRS
E
L
F
L
T
T
K
V
W
V
D
N
Y
A
R
E
K
L
L
A
S
L
R
E
S
L
E
K
L
RTDRL
D
L
V
L
I
HWP-----------------A---------PG--------------N------------G--------V-----
E
L
G
E
Y
M
A
A
---
L
A
E
A
K
SLGL
T
R
RIGVSNF------
N
I
E
L
T
R
Q
A
--
I
A
A
VGAG-EIS--T
N
Q
I
E
L
S
P
Y
L
QN
R
A
L
T
A
Y
L
E
EQG
I
A
V
T
S
Y
M
T
L
A
-----
Y
G
--
K
----------VL-------KDP
T
L
A
G
I
A
A
R
H
R
A
T
V
A
Q
V
A
L
A
W
A
M
Q
L-G
Y
A
VIPS
S
T
R
R
E
-
N
L
A
S
N
-
L
L
A
R
D
LRL
D
A
E
D
M
A
R
I
AGLER-N-GR-EVS-PQGLAPAWD
111
HHSearch
87.69
46%
-94
- C3 -
3UP8
1
?
A:
[27-297]
V
S
S
N
G
A
---
N
I
P
A
L
G
F
G
T
F
R
M
-
S
-
G
-
A
E
V
L
R
I
L
P
Q
A
L
K
L
G
F
R
H
V
D
T
A
Q
I
Y
G
N
E
A
E
V
G
E
A
I
----
Q
----
K
S
-----
G
I
P
R
A
D
V
F
L
T
T
K
V
W
V
D
N
Y
R
H
D
A
F
I
A
S
V
D
E
S
L
R
K
L
R
T
D
H
V
D
L
L
L
L
H
W
P
-----------------
G
---------
S
D
--------------
V
---------------------------
P
M
A
E
R
I
G
A
---
L
N
E
V
R
N
A
G
K
V
R
H
I
G
I
S
N
F
------
N
T
T
Q
M
E
E
A
--
A
R
L
S
D
-
A
-
P
I
A
--
T
N
Q
V
E
Y
H
P
Y
L
D
Q
T
K
V
L
Q
T
A
R
R
L
G
M
S
L
T
S
Y
Y
A
M
A
-----
N
G
--
K
----------
V
P
-------
A
D
P
L
L
T
E
I
G
G
R
H
G
K
T
A
A
Q
V
A
L
R
W
L
V
Q
Q
Q
D
V
I
V
L
S
K
T
A
T
E
A
-
R
L
K
E
N
F
A
I
F
D
-
F
A
L
T
R
E
E
M
A
A
V
R
E
L
A
R
-
P
N
G
R
-
I
V
N
-
P
Q
G
L
A
P
E
W
D
1
PsiBlast_PDB
86.08
46%
-88
- C3 -
3UP8
1
?
A:
[27-297]
V
S
S
N
G
A
---
N
I
P
A
L
G
F
G
T
F
R
M
-
S
-
G
-
A
E
V
L
R
I
L
P
Q
A
L
K
L
G
F
R
H
V
D
T
A
Q
I
Y
G
N
E
A
E
V
G
E
A
I
----
Q
----
K
S
-----
G
I
P
R
A
D
V
F
L
T
T
K
V
W
V
D
N
Y
R
H
D
A
F
I
A
S
V
D
E
S
L
R
K
L
R
T
D
H
V
D
L
L
L
L
H
W
----------------------------
P
G
--------------
S
------------
D
--------
V
-----
P
M
A
E
R
I
G
A
---
L
N
E
V
R
N
A
G
K
V
R
H
I
G
I
S
N
F
------
N
T
T
Q
M
E
E
A
---
A
R
L
S
D
A
-
P
I
A
--
T
N
Q
V
E
Y
H
P
Y
L
D
Q
T
K
V
L
Q
T
A
R
R
L
G
M
S
L
T
S
Y
Y
A
M
A
-----
N
G
--
K
----------
V
P
-------
A
D
P
L
L
T
E
I
G
G
R
H
G
K
T
A
A
Q
V
A
L
R
W
L
V
Q
Q
-
Q
D
V
I
V
L
S
K
T
A
T
E
A
R
L
K
E
N
-
F
A
I
F
D
F
A
L
T
R
E
E
M
A
A
V
R
E
L
A
R
P
N
-
G
R
-
I
V
N
-
P
Q
G
L
A
P
E
W
D
63
PsiBlast_CBE
84.45
34%
-101
- C3 -
3LQG
3
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
A
GFK------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
70
PsiBlast_CBE
84.31
33%
-103
- C3 -
3LEP
4
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
C
GFK------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
39
PsiBlast_CBE
84.25
39%
-96
- C3 -
3B3D
1
YTBE_BACSU
B:
[42-307]
-
K
A
T
L
H
NG
V
E
M
P
W
F
G
L
G
V
F
Q
V
-
E
E
G
-
S
E
L
V
N
A
V
K
T
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
E
----
E
A
-----
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
V
---------
E
G
------------------------------------------
K
Y
K
E
A
W
R
A
---
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
------
Q
I
H
H
L
E
D
L
--
M
T
A
A
----
E
I
K
PM
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
M
-----
Q
G
--
Q
----------
L
L
-------
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
-
G
I
I
T
I
P
K
S
T
K
E
H
-
R
I
K
E
N
-
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
E
-
N
-
L
R
--
V
G
-
P
--------
62
PsiBlast_CBE
84.23
34%
-101
- C3 -
3LQL
4
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
A
GFK------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
64
PsiBlast_CBE
84.12
34%
-99
- C3 -
2ISF
2
ALDR_HUMAN
A:
[12-296]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
Y
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
38
PsiBlast_CBE
83.92
39%
-95
- C3 -
3B3D
1
YTBE_BACSU
C:
[42-307]
-
K
A
T
L
H
NGV
E
M
P
W
F
G
L
G
V
F
Q
V
-
E
E
G
-
S
E
L
V
N
A
V
K
T
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
REGI
E
----
E
A
-----
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
V
---------
E
G
------------------------------------------
K
Y
K
E
A
W
R
A
---
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
------
Q
I
H
H
L
E
D
L
--
M
T
A
A
----
E
I
K
PM
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
M
-----
Q
G
--
Q
----------
L
L
-------
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
-
G
I
I
T
I
P
K
S
T
K
E
H
-
R
I
K
E
N
-
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
E
-
N
-
L
R
--
V
G
-
P
--------
73
PsiBlast_CBE
83.87
33%
-98
- C3 -
3LEN
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
S
G
F
K------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
67
PsiBlast_CBE
83.80
34%
-98
- C3 -
1AZ1
3
ALDR_HUMAN
A:
[12-296]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
Y
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
94
PsiBlast_CBE
83.74
33%
-100
- C3 -
2PDU
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
96
PsiBlast_CBE
83.69
33%
-99
- C3 -
4QXI
2
?
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
72
PsiBlast_CBE
83.67
33%
-102
- C3 -
3LZ3
4
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
S
GFK------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
84
PsiBlast_CBE
83.53
33%
-98
- C3 -
2F2K
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
61
PsiBlast_CBE
83.52
34%
-98
- C3 -
3MB9
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
A
G
F
K------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
78
PsiBlast_CBE
83.50
33%
-99
- C3 -
2PDI
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
15
PsiBlast_PDB
83.47
39%
-95
- C3 -
3B3D
1
YTBE_BACSU
A:
[42-307]
-
K
A
T
L
H
NG
V
E
M
P
W
F
G
L
G
V
F
Q
V
-
E
E
G
-
S
E
L
V
N
A
V
K
T
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
E
----
E
A
-----
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
V
---------
E
G
------------------------------------------
K
Y
K
E
A
W
R
A
---
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
------
Q
I
H
H
L
E
D
L
--
M
T
A
A
----
E
I
K
PM
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
M
-----
Q
G
--
Q
----------
L
L
-------
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
-
G
I
I
T
I
P
K
S
T
K
E
H
-
R
I
K
E
N
-
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
E
-
N
-
L
R
--
V
G
-
P
--------
59
PsiBlast_CBE
83.45
34%
-100
- C3 -
3ONC
4
ALDR_HUMAN
A:
[12-296]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
A
GFK------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
69
PsiBlast_CBE
83.33
34%
-99
- C3 -
2PD5
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
I
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
82
PsiBlast_CBE
83.24
33%
-99
- C3 -
4GCA
2
ALDR_HUMAN
A:
[12-296]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
57
PsiBlast_CBE
83.23
33%
-97
- C3 -
2AGT
4
ALDR_HUMAN
A:
[16-304]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
-
V
C
A
-
P
--------
74
PsiBlast_CBE
83.10
33%
-100
- C3 -
3LD5
4
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
S
GFK------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
79
PsiBlast_CBE
82.86
33%
-98
- C3 -
4Q7B
2
ALDR_HUMAN
A:
[12-296]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
83
PsiBlast_CBE
82.82
33%
-99
- C3 -
4JIR
4
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
81
PsiBlast_CBE
82.80
33%
-100
- C3 -
4PR4
2
ALDR_HUMAN
A:
[12-296]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
85
PsiBlast_CBE
82.77
33%
-99
- C3 -
1T40
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
87
PsiBlast_CBE
82.72
33%
-100
- C3 -
1EL3
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
99
PsiBlast_CBE
82.65
33%
-99
- C3 -
4QBX
3
?
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
98
PsiBlast_CBE
82.63
33%
-98
- C3 -
4QR6
2
?
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
76
PsiBlast_CBE
82.61
33%
-99
- C3 -
2PDK
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
80
PsiBlast_CBE
82.60
33%
-99
- C3 -
4PRR
2
ALDR_HUMAN
A:
[12-296]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
93
PsiBlast_CBE
82.57
33%
-99
- C3 -
2PDW
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
89
PsiBlast_CBE
82.52
33%
-99
- C3 -
2PDB
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K------
P
G
KEP
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
65
PsiBlast_CBE
82.52
34%
-99
- C3 -
2IPW
2
ALDR_HUMAN
A:
[12-296]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEFFPLDN
V
V
P
---
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
Y
A
---EDPS------
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
88
PsiBlast_CBE
82.36
33%
-99
- C3 -
2PDC
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K------
P
G
KEP
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
58
PsiBlast_CBE
82.36
34%
-99
- C3 -
2IS7
2
ALDR_HUMAN
A:
[12-296]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
E
S
-----
N
------------
G
--------
V
V
P
S
DT
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
D
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
77
PsiBlast_CBE
82.35
33%
-96
- C3 -
2PDJ
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
95
PsiBlast_CBE
82.34
33%
-97
- C3 -
2PDQ
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
92
PsiBlast_CBE
82.32
33%
-100
- C3 -
1Z3N
2
ALDR_HUMAN
A:
[16-300]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
36
PsiBlast_CBE
82.30
37%
-91
- C3 -
4G5D
1
PGFS_LEIMA
B:
[21-278]
----------
M
P
Q
F
G
L
G
V
W
Q
S
P
A
-
G
-
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
----
R
----
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
-----------------
R
---------
G
K
--------------
D
I
L
S
K
E-------
G
--------
K
-----
K
Y
L
D
S
W
R
A
---
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
------
H
I
H
H
L
E
D
V
--
L
A
M
C
T
V
T
-
P
M
---
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
-----
Q
G
--
K
----------
L
L
-------
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
-
N
L
I
T
I
P
K
S
V
H
R
E
-
R
I
E
E
N
-
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
-
N
-
S
R
--------------
97
PsiBlast_CBE
82.26
33%
-98
- C3 -
4QX4
3
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
60
PsiBlast_CBE
82.17
34%
-99
- C3 -
3ONB
4
ALDR_HUMAN
A:
[12-296]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
A
GFK------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
100
PsiBlast_CBE
82.16
33%
-97
- C3 -
4PUW
3
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
91
PsiBlast_CBE
81.98
33%
-99
- C3 -
3G5E
2
ALDR_HUMAN
A:
[16-300]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
68
PsiBlast_CBE
81.95
34%
-98
- C3 -
2PD9
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
I
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
14
PsiBlast_PDB
81.77
37%
-91
- C3 -
4G5D
1
PGFS_LEIMA
A:
[21-278]
----------
M
P
Q
F
G
L
G
V
W
Q
S
P
A
-
G
-
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
----
R
----
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
-----------------
R
---------
G
K
--------------
D
I
L
S
K
E-------
G
--------
K
-----
K
Y
L
D
S
W
R
A
---
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
------
H
I
H
H
L
E
D
V
--
L
A
M
C
T
V
T
-
P
M
---
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
-----
Q
G
--
K
----------
L
L
-------
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
-
N
L
I
T
I
P
K
S
V
H
R
E
-
R
I
E
E
N
-
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
-
N
-
S
R
--------------
75
PsiBlast_CBE
81.59
33%
-99
- C3 -
2PDL
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
90
PsiBlast_CBE
81.45
33%
-97
- C3 -
3T42
3
ALDR_HUMAN
A:
[16-300]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K------
P
G
KEF
F
P
L
D
ES
G
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
40
PsiBlast_CBE
81.21
40%
-96
- C3 -
2WZM
1
Y2407_MYCS2
B:
[22-272]
----------
L
P
V
V
G
I
G
V
G
E
L
-
S
-
D
-
S
E
A
E
R
S
V
S
A
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
N
E
A
A
V
G
R
A
I
----
A
----
A
S
-----
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
-----------------
G
----------
G
--------------
D
------------
T
--------
S
-----
K
Y
V
D
S
W
G
G
---
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
------
G
A
E
-
D
L
E
T
--
I
V
S
L
T
Y
F
-
T
P
A
--
V
N
Q
I
E
L
H
P
L
L
N
Q
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
G
-----
V
G
--
R
----------
L
L
-------
D
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
-
G
N
V
V
I
S
R
S
A
N
P
E
-
R
I
A
S
N
-
L
D
V
F
G
F
E
L
T
A
D
E
M
E
T
L
N
G
L
D
D
-
G
-
T
R
--------------
16
PsiBlast_PDB
80.90
40%
-95
- C3 -
2WZM
1
Y2407_MYCS2
A:
[22-272]
----------
L
P
V
V
G
I
G
V
G
E
L
-
S
-
D
-
S
E
A
E
R
S
V
S
A
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
N
E
A
A
V
G
R
A
I
----
A
----
A
S
-----
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
-----------------
G
----------
G
--------------
D
------------
T
--------
S
-----
K
Y
V
D
S
W
G
G
---
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
------
G
A
E
-
D
L
E
T
--
I
V
S
L
T
Y
F
-
T
P
A
--
V
N
Q
I
E
L
H
P
L
L
N
Q
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
G
-----
V
G
--
R
----------
L
L
-------
D
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
-
G
N
V
V
I
S
R
S
A
N
P
E
-
R
I
A
S
N
-
L
D
V
F
G
F
E
L
T
A
D
E
M
E
T
L
N
G
L
D
D
-
G
-
T
R
--------------
66
PsiBlast_CBE
80.24
34%
-92
- C3 -
1AZ2
2
ALDR_HUMAN
A:
[12-296]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
GFK------
P
G
KEF
F
P
L
D
ESG
N
V
V
P
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
Y
A
--
K
P
E
D
P
S
-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
5
PsiBlast_PDB
80.05
36%
-83
- C3 -
4FZI
1
PGFS_TRYCC
A:
[24-287]
----------
M
P
Q
L
G
L
G
V
W
R
A
-
Q
D
G
-
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
----
R
----
E
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
-----------------
G
---------
K
K
--------------
K
------------
F
--------
V
-----
D
T
W
K
A
L
E
K
---
L
Y
E
E
K
K
V
---
R
A
I
G
V
S
N
F
------
E
P
H
H
L
T
E
L
--
F
K
S
C
K
I
R
-
P
M
---
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
-----
S
G
--
E
EAG-------
I
L
-------
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
-
G
I
V
T
I
P
K
S
T
N
K
G
-
R
I
Q
E
N
-
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
E
-
D
-
K
R
I
G
A
D
-
P
D
N
F
F
P
G
--
114
HHSearch
79.96
38%
-93
- C3 -
2WZM
1
Y2407_MYCS2
A:
[16-274]
L
N
-
D
D
N
---
T
L
P
V
V
G
I
G
V
G
E
L
-
S
-
D
-
S
E
A
E
R
S
V
S
A
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
N
E
A
A
V
G
R
A
I
----
A
----
A
S
-----
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
-----------------
G
---------
G
D
--------------
T
---------------------
S
-----
K
Y
V
D
S
W
G
G
---
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
------
G
A
E
D
L
E
T
I
--
V
S
L
T
Y
-
F
-
T
P
A
--
V
N
Q
I
E
L
H
P
L
L
N
Q
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
G
-----
V
G
--
R
----------
L
L
-------
D
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
-
G
N
V
V
I
S
R
S
A
N
P
E
-
R
I
A
S
N
L
D
V
F
G
-
F
E
L
T
A
D
E
M
E
T
L
N
G
L
D
D
-
G
-
T
R
-
F
R
-----------
37
PsiBlast_CBE
79.91
37%
-93
- C3 -
4F40
7
PGFS_LEIMA
B:
[21-278]
----------
M
P
Q
F
G
L
G
V
W
Q
S
P
A
-
G
-
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
----
R
----
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
-----------------
R
---------
G
K
--------------
D
ILSKE-------
G
--------
K
-----
K
Y
L
D
S
W
R
A
---
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
------
H
I
H
H
L
E
D
V
--
L
A
M
C
T
V
T
-
P
M
---
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
---------
K
----------
L
L
-------
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
-
N
L
I
T
I
P
K
S
V
H
R
E
-
R
I
E
E
N
-
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
-
N
-
S
R
--------------
2
PsiBlast_PDB
79.52
39%
-89
- C3 -
3WBW
2
?
A:
[23-272]
-----
H
---
T
M
P
Q
I
G
L
G
V
W
E
T
-
P
-
P
-
D
E
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
----
E
----
D
---------
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
-----------------
M
---------
P
A
--------------
Q
------------
G
--------------
Q
Y
V
E
T
W
K
A
---
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
------
E
S
E
H
L
E
R
I
--
M
D
A
T
G
V
V
-
P
V
---
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
-----
K
G
--
R
----------
V
L
-------
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
-
R
L
A
E
N
-
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
-
G
R
--------------
13
PsiBlast_PDB
79.51
37%
-90
- C3 -
4F40
9
PGFS_LEIMA
A:
[21-278]
----------
M
P
Q
F
G
L
G
V
W
Q
S
P
A
-
G
-
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
----
R
----
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
-----------------
R
---------
G
K
--------------
D
I
L
S
K
E-------
G
--------
K
-----
K
Y
L
D
S
W
R
A
---
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
------
H
I
H
H
L
E
D
V
--
L
A
M
C
T
V
T
-
P
M
---
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
---------
K
----------
L
L
-------
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
-
N
L
I
T
I
P
K
S
V
H
R
E
-
R
I
E
E
N
-
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
-
N
-
S
R
--------------
22
PsiBlast_CBE
79.48
39%
-92
- C3 -
3WBW
3
?
B:
[23-272]
-----
H
---
T
M
P
Q
I
G
L
G
V
W
E
T
-
P
-
P
-
D
E
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
----
E
----
D
---------
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
-----------------
M
---------
P
A
--------------
Q
------------
G
--------------
Q
Y
V
E
T
W
K
A
---
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
------
E
S
E
H
L
E
R
I
--
M
D
A
T
G
V
V
-
P
V
---
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
-----
K
G
--
R
----------
V
L
-------
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
-
R
L
A
E
N
-
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
-
G
R
--------------
6
PsiBlast_PDB
79.33
36%
-84
- C3 -
4GIE
2
PGFS_TRYCC
A:
[24-287]
----------
M
P
Q
L
G
L
G
V
W
R
A
-
Q
D
G
-
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
----
R
----
E
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
-----------------
G
---------
K
K
--------------
K
------------
F
--------
V
-----
D
T
W
K
A
L
E
K
---
L
Y
E
E
K
K
V
---
R
A
I
G
V
S
N
F
------
E
P
H
H
L
T
E
L
--
F
K
S
C
K
I
R
-
P
M
---
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
-----
S
G
--
E
EAG-------
I
L
-------
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
-
G
I
V
T
I
P
K
S
T
N
K
G
-
R
I
Q
E
N
-
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
E
-
D
-
K
R
I
G
A
D
-
P
D
N
F
F
P
G
--
26
PsiBlast_CBE
79.13
36%
-85
- C3 -
4FZI
2
PGFS_TRYCC
B:
[24-287]
----------
M
P
Q
L
G
L
G
V
W
R
A
-
Q
D
G
-
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
----
R
----
E
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
-----------------
G
---------
K
K
--------------
K
------------
F
--------
V
-----
D
T
W
K
A
L
E
K
---
L
Y
E
E
K
K
V
---
R
A
I
G
V
S
N
F
------
E
P
H
H
L
T
E
L
--
F
K
S
C
K
I
R
-
P
M
---
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
-----
S
--------------
I
L
-------
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
-
G
I
V
T
I
P
K
S
T
N
K
G
-
R
I
Q
E
N
-
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
E
-
D
-
K
R
I
G
A
D
-
P
D
N
F
F
P
G
--
52
PsiBlast_CBE
79.06
31%
-97
- C3 -
4GAC
2
AK1A1_MOUSE
A:
[13-300]
----------
M
P
L
I
G
L
G
T
W
K
S
-
E
-
P
-
G
Q
V
K
A
A
I
K
H
A
L
S
A
G
Y
R
H
I
D
C
A
S
V
Y
G
N
E
T
E
I
G
E
A
L
----
K
----
E
S
VGSGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
-----------------
Y
A
F
ERGDNPF
P
K
--------------
N
------------
A
DG
T
V
R
Y
D
S
T
-----
H
Y
K
E
T
W
K
A
---
L
E
V
L
V
A
K
G
L
V
K
A
L
G
L
S
N
F
------
N
---
S
R
Q
I
D
D
V
L
S
V
A
S
V
-
R
P
A
--
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
H
A
R
G
L
E
V
T
A
Y
S
P
L
G
-----
S
S
--
D
RAWRHPDEPV
L
L
-------
E
E
P
V
V
L
A
L
A
E
K
H
G
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
-
K
V
I
C
I
P
K
S
I
N
P
S
-
R
I
L
Q
N
-
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
K
-
N
-
W
R
-
Y
I
V
-
P
--------
11
PsiBlast_PDB
78.84
39%
-87
- C3 -
3D3F
1
GR_BACSU
A:
[16-265]
----------
M
P
W
F
G
L
G
V
F
K
V
E
N
-
G
-
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
----
K
----
E
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
G
---------
K
D
------------------------------------------
K
Y
K
D
T
W
R
A
---
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
------
Q
V
H
H
L
E
E
L
--
L
K
---
D
A
-
E
I
K
PM
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
-----
Q
G
--
Q
----------
L
L
-------
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
-
G
V
V
T
I
P
K
S
I
K
E
H
-
R
I
I
E
N
-
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
K
-
D
-
E
R
--------------
42
PsiBlast_CBE
78.78
39%
-86
- C3 -
1M9H
2
DKGA_CORSC
A:
[14-262]
----------
I
P
Q
L
G
Y
G
V
Y
K
V
-
P
-
P
-
A
D
T
Q
R
A
V
E
E
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
G
V
G
A
A
I
----
A
----
A
S
-----
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
-----------------
T
---------
P
A
AD------------
N
------------
Y
--------
V
-----
H
A
W
E
K
M
I
E
---
L
---
R
A
A
G
L
T
R
S
I
G
V
S
N
H
------
L
V
P
H
L
E
R
I
--
V
A
A
T
G
V
V
-
P
-
A
--
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
G
-----
Q
G
--
K
YD--------
L
F
-------
G
A
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
-
G
F
V
V
F
P
G
S
V
R
R
E
-
H
L
E
E
N
-
L
D
V
F
D
F
D
L
T
D
T
E
I
A
A
I
D
A
M
D
--------------------
19
PsiBlast_PDB
78.65
39%
-90
- C3 -
1A80
1
DKGA_CORSC
A:
[13-261]
----------
I
P
Q
L
G
Y
G
V
F
K
V
-
P
-
P
-
A
D
T
Q
R
A
V
E
E
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
G
V
G
A
A
I
----
A
----
A
S
-----
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
-----------------
T
---------
P
A
AD------------
N
------------
Y
--------
V
-----
H
A
W
E
K
M
I
E
---
L
---
R
A
A
G
L
T
R
S
I
G
V
S
N
H
------
L
V
P
H
L
E
R
I
--
V
A
A
T
G
V
V
-
P
-
A
--
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
G
-----
Q
G
--
K
YD--------
L
F
-------
G
A
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
-
G
F
V
V
F
P
K
S
V
R
R
E
-
R
L
E
E
N
-
L
D
V
F
D
F
D
L
T
D
T
E
I
A
A
I
D
A
M
D
--------------------
34
PsiBlast_CBE
78.55
39%
-93
- C3 -
3D3F
1
GR_BACSU
B:
[16-265]
----------
M
P
W
F
G
L
G
V
F
K
V
E
N
-
G
-
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
----
K
----
E
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
G
---------
K
D
------------------------------------------
K
Y
K
D
T
W
R
A
---
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
------
Q
V
H
H
L
E
E
L
--
L
K
---
D
A
-
E
I
K
PM
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
-----
Q
G
--
Q
----------
L
L
-------
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
-
G
V
V
T
I
P
K
S
I
K
E
H
-
R
I
I
E
N
-
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
K
-
D
-
E
R
--------------
86
PsiBlast_CBE
78.37
33%
-92
- C3 -
1IEI
2
ALDR_HUMAN
A:
[13-297]
----------
M
P
I
L
G
L
G
T
W
K
S
-
P
-
P
-
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
----
Q
----
E
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
-----------------
T
G
F
K
------
P
G
KEF
F
P
L
D
ESGNVVP
S
------------
D
--------
T
-----
N
I
L
D
T
W
A
A
---
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
------
N
H
L
Q
V
E
M
I
--
L
N
K
P
G
L
K
Y
K
P
A
--
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
-
N
L
V
V
I
P
K
S
V
T
P
E
-
R
I
A
E
N
-
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
-
W
R
--------------
126
HHSearch
78.21
39%
-93
- C3 -
3WBW
2
?
A:
[19-270]
-
F
H
D
G
H
---
T
M
P
Q
I
G
L
G
V
W
E
T
-
P
-
P
-
D
E
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
----
E
-------------
D
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
-----------------
M
---------
P
A
--------------
Q
---------------------
G
-----
Q
Y
V
E
T
W
K
A
---
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
------
E
S
E
H
L
E
R
I
--
M
D
A
T
G
-
V
-
V
P
V
--
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
-----
K
G
--
R
----------
V
L
-------
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
-
R
L
A
E
N
L
D
V
F
G
-
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R
-
K
-
D
---------------
43
PsiBlast_CBE
77.55
32%
-95
- C3 -
4I5X
2
AK1BA_HUMAN
A:
[10-299]
--
S
T
K
A
---
K
M
P
I
V
G
L
G
T
W
K
S
-
P
-
L
-
G
K
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
----
Q
----
E
K
I
Q
E
K-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDLFPKDDKG
N
A
---------
I
G
--------------
G
------------
K
--------
A
-----
T
F
L
D
A
W
E
A
---
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
------
S
H
F
Q
I
E
K
L
--
L
N
K
P
G
L
K
Y
K
P
V
--
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
SPDRP
W
A
--
K
PEDPS-----
L
L
-------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
-
N
V
I
V
I
P
K
S
V
T
P
A
-
R
I
V
E
N
-
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
R
-
N
-
W
R
--------------
27
PsiBlast_CBE
77.39
39%
-92
- C3 -
3WBY
1
?
B:
[23-272]
-----
H
---
T
M
P
Q
I
G
L
G
V
W
E
T
-
P
-
P
-
D
E
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
A
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
----
E
----
D
---------
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
-----------------
M
---------
P
A
--------------
Q
------------
G
--------------
Q
Y
V
E
T
W
K
A
---
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
------
E
S
E
H
L
E
R
I
--
M
D
A
T
G
V
V
-
P
V
---
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
-----
K
G
--
R
----------
V
L
-------
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
-
R
L
A
E
N
-
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
-
G
R
--------------
7
PsiBlast_PDB
76.54
39%
-90
- C3 -
3WBY
2
?
A:
[23-272]
-----
H
---
T
M
P
Q
I
G
L
G
V
W
E
T
-
P
-
P
-
D
E
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
A
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
----
E
----
D
---------
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
-----------------
M
---------
P
A
--------------
Q
------------
G
--------------
Q
Y
V
E
T
W
K
A
---
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
------
E
S
E
H
L
E
R
I
--
M
D
A
T
G
V
V
-
P
V
---
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
-----
K
G
--
R
----------
V
L
-------
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
-
R
L
A
E
N
-
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
-
G
R
--------------
23
PsiBlast_CBE
75.61
38%
-88
- C3 -
3O0K
3
?
D:
[37-283]
----------
I
P
Q
L
G
Y
G
V
W
Q
I
-
S
-
N
-
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
----
N
----
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-----------------
M
---------
P
S
--------------
K
------------
D
--------
L
-----
F
M
-
E
T
W
R
A
---
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
------
R
T
A
D
L
E
R
L
--
I
K
E
S
G
V
T
-
P
V
---
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
---------
K
----------
L
L
-------
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
-
R
I
K
E
N
-
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
--------------------
25
PsiBlast_CBE
75.50
38%
-90
- C3 -
3O0K
4
?
B:
[37-283]
----------
I
P
Q
L
G
Y
G
V
W
Q
I
-
S
-
N
-
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
----
N
----
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-----------------
M
---------
P
S
--------------
K
------------
D
--------
L
-----
F
M
-
E
T
W
R
A
---
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
------
R
T
A
D
L
E
R
L
--
I
K
E
S
G
V
T
-
P
V
---
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
--------------------
L
L
-------
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
-
R
I
K
E
N
-
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
--------------------
18
PsiBlast_PDB
75.49
36%
-89
- C3 -
1VBJ
2
PGFS_TRYBB
A:
[20-269]
----------
M
P
V
L
G
F
G
M
W
K
L
-
Q
D
G
-
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
----
A
----
S
C
-----
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
-----------------
G
---------
K
D
--------------
K
------------
F
--------
I
-----
D
T
W
K
A
F
E
K
---
L
Y
A
D
K
K
V
---
R
A
I
G
V
S
N
F
------
H
E
H
H
I
E
E
L
--
L
K
H
C
K
V
A
-
P
M
---
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
-----
Q
G
--
H
----------
L
V
-------
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
-
G
V
I
T
I
P
K
S
G
N
E
A
-
R
I
K
E
N
-
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
A
-
G
-
H
R
--------------
24
PsiBlast_CBE
75.38
38%
-93
- C3 -
3O0K
3
?
C:
[37-283]
----------
I
P
Q
L
G
Y
G
V
W
Q
I
-
S
-
N
-
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
----
N
----
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-----------------
M
---------
P
S
--------------
K
------------
D
--------
L
-----
F
M
-
E
T
W
R
A
---
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
------
R
T
A
D
L
E
R
L
--
I
K
E
S
G
V
T
-
P
V
---
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
--------------------
L
L
-------
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
-
R
I
K
E
N
-
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
--------------------
118
HHSearch
75.26
38%
-92
- C3 -
3O0K
4
?
A:
[32-282]
--
N
D
G
N
---
H
I
P
Q
L
G
Y
G
V
W
Q
I
-
S
-
N
-
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
----
N
----
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-----------------
M
---------
P
S
--------------
K
------------
D
--------------
L
F
M
E
T
W
R
A
---
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
------
R
T
A
D
L
E
R
L
--
I
K
E
S
G
-
V
-
T
P
V
--
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
-----
Q
G
-------------
L
L
-------
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
-
R
I
K
E
N
F
D
I
F
D
-
F
T
L
N
G
T
D
H
D
A
I
T
K
L
---------------------
41
PsiBlast_CBE
75.16
36%
-87
- C3 -
1VBJ
2
PGFS_TRYBB
B:
[20-269]
----------
M
P
V
L
G
F
G
M
W
K
L
-
Q
D
G
-
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
----
A
----
S
C
-----
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
-----------------
G
---------
K
D
--------------
K
------------
F
--------
I
-----
D
T
W
K
A
F
E
K
---
L
Y
A
D
K
K
V
---
R
A
I
G
V
S
N
F
------
H
E
H
H
I
E
E
L
--
L
K
H
C
K
V
A
-
P
M
---
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
-----
Q
G
--
H
----------
L
V
-------
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
-
G
V
I
T
I
P
K
S
G
N
E
A
-
R
I
K
E
N
-
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
A
-
G
-
H
R
--------------
9
PsiBlast_PDB
74.86
35%
-82
- C3 -
1MZR
4
DKGA_ECOLI
A:
[36-289]
----------
M
P
Q
L
G
L
G
V
W
Q
A
-
S
-
N
-
E
E
V
I
T
A
I
Q
K
A
L
E
V
G
Y
R
S
I
D
T
A
A
A
Y
K
N
E
E
G
V
G
K
A
L
----
K
----
N
A
-----
S
V
N
R
E
E
L
F
I
T
T
K
L
W
N
D
D
H
K
R
P
R
--
E
A
L
L
D
S
L
K
K
L
Q
L
D
Y
I
D
L
Y
L
M
H
W
P
-----------------
V
---------
P
A
-------------------------------------------
I
D
H
Y
V
E
A
W
K
G
M
I
E
L
Q
K
E
G
L
I
K
S
I
G
V
C
N
F
------
Q
I
H
H
L
Q
R
L
--
I
D
E
T
G
V
T
-
P
V
---
I
N
Q
I
E
L
H
P
L
M
Q
Q
R
Q
L
H
A
W
N
A
T
H
K
I
Q
T
E
S
W
S
P
L
A
-----
Q
G
GK
G
----------
V
F
-------
D
Q
K
V
I
R
D
L
A
D
K
Y
G
K
T
P
A
Q
I
V
I
R
W
H
L
D
S
-
G
L
V
V
I
P
K
S
V
T
P
S
-
R
I
A
E
N
-
F
D
V
W
D
F
R
L
D
K
D
E
L
G
E
I
A
K
L
D
Q
---
G
K
-
R
L
G
-
P
--------
112
HHSearch
74.71
35%
-86
- C3 -
1VBJ
2
PGFS_TRYBB
A:
[14-278]
-
L
S
N
G
V
---
M
M
P
V
L
G
F
G
M
W
K
L
-
Q
-
D
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
----
A
----
S
C
-----
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
-----------------
G
---------
K
D
------------------------------------------
K
F
I
D
T
W
K
A
---
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
------
H
E
H
H
I
E
E
L
--
L
K
H
C
K
-
V
-
A
P
M
--
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
-----
Q
G
--
H
----------
L
V
-------
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
-
G
V
I
T
I
P
K
S
G
N
E
A
-
R
I
K
E
N
G
N
I
F
D
-
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
A
-
G
-
H
R
-
Y
G
P
D
P
E
V
F
M
----
4
PsiBlast_PDB
74.71
38%
-87
- C3 -
3O0K
4
?
A:
[37-283]
----------
I
P
Q
L
G
Y
G
V
W
Q
I
-
S
-
N
-
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
----
N
----
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-----------------
M
---------
P
S
--------------
K
------------
D
--------
L
-----
F
M
-
E
T
W
R
A
---
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
------
R
T
A
D
L
E
R
L
--
I
K
E
S
G
V
T
-
P
V
---
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
-----
Q
G
-------------
L
L
-------
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
-
R
I
K
E
N
-
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
--------------------
122
HHSearch
74.06
32%
-90
- C3 -
3H7U
2
AKRC9_ARATH
A:
[29-316]
K
L
N
T
G
A
---
K
F
P
S
V
G
L
G
T
W
Q
A
-
S
-
P
-
G
L
V
G
D
A
V
A
A
A
V
K
I
G
Y
R
H
I
D
C
A
Q
I
Y
G
N
E
K
E
I
G
A
V
L
----
K
----
K
L
F
E
D
R-
V
V
K
R
E
D
L
F
I
T
S
K
L
W
C
T
D
H
D
P
Q
D
V
P
E
A
L
N
R
T
L
K
D
L
Q
L
E
Y
V
D
L
Y
L
I
H
W
P
-----------------
A
---------
R
I
--------------
K
K
GSVGIKPENLL
P
--------
V
-----
D
I
P
S
T
W
K
A
---
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
------
S
T
K
K
L
A
D
L
--
L
E
L
A
R
-
V
-
P
P
A
--
V
N
Q
V
E
C
H
P
S
W
R
Q
T
K
L
Q
E
F
C
K
S
K
G
V
H
L
S
A
Y
S
P
L
G
-----
S
P
--
G
----------
T
T
WLKSDVL
K
N
P
I
L
N
M
V
A
E
K
L
G
K
S
P
A
Q
V
A
L
R
W
G
L
Q
M
-
G
H
S
V
L
P
K
S
T
N
E
G
-
R
I
K
E
N
F
N
V
F
D
-
W
S
I
P
D
Y
M
F
A
K
F
A
E
I
E
Q
---
A
R
-
L
V
T
-
G
S
F
L
-----
113
HHSearch
71.27
33%
-82
- C3 -
1VP5
1
?
A:
[19-287]
T
L
N
N
G
V
---
E
M
P
I
L
G
Y
G
V
F
Q
I
-
P
-
P
-
E
K
T
E
E
C
V
Y
E
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
I
----
K
----
R
A
I
D
E
G-
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
P
-----------------
F
---------
G
D
-------------------------------------------
V
H
C
A
W
K
A
---
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
------
Y
P
D
R
L
M
D
L
--
M
V
H
H
E
-
I
-
V
P
A
--
V
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
A
-----
E
G
--
R
----------
K
N
IF-----
Q
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
-
G
I
V
A
I
P
K
T
V
R
R
E
-
R
M
K
E
N
I
S
I
F
D
-
F
E
L
T
Q
E
D
M
E
K
I
A
T
L
D
E
-
G
-
Q
S
-
A
F
F
-
S
H
R
D
P
----
54
PsiBlast_CBE
71.18
34%
-103
- C3 -
1VP5
1
?
A:
[26-275]
----------
M
P
I
L
G
Y
G
V
F
Q
I
-
P
-
P
-
E
K
T
E
E
C
V
Y
E
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
I
----
K
R
A
I
D
E
G
-----
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
P
------------------------------------------------------------------------
F
G
D
V
H
C
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
V
H
H
E
I
--
V
P
A
V
----------
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
A
-----
E
G
--
R
KN--------
I
F
-------
Q
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
-
G
I
V
A
I
P
K
T
V
R
R
E
-
R
M
K
E
N
-
I
S
I
F
D
F
E
L
T
Q
E
D
M
E
K
I
A
T
L
D
--------------------
53
PsiBlast_CBE
70.29
34%
-103
- C3 -
1VP5
1
?
B:
[26-275]
----------
M
P
I
L
G
Y
G
V
F
Q
I
-
P
-
P
-
E
K
T
E
E
C
V
Y
E
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
I
----
K
RAID
E
G
-----
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
P
------------------------------------------------------------------------
F
G
D
V
H
C
A
WKA
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
YPDRLM
D
L
M
V
H
H
E
I
--
V
P
A
V
----------
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
A
-----
E
G
--
R
KN--------
I
F
-------
Q
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
-
G
I
V
A
I
P
K
T
V
R
R
E
-
R
M
K
E
N
-
I
S
I
F
D
F
E
L
T
Q
E
D
M
E
K
I
A
T
L
D
--------------------