@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4234: (2016-02-25 )
MDKILIRGARTHNLKNVDLTLPRDKLIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSMMEKPDVDTIEGLSPAISIEQKSTSHNPRSTVGTITEIYDYLRLLYARVGTPRCPDHDIPLEAQTVSQMVDQVLALPEGSKLMLLAPVIRERKGEHLAVFDEMRAQGFVRARVDGKLYELDEVPKLDKQKKHSIDVVVDRFKVRADLQQRLAESFETALSLADGIALVAPMDEDEDVEEIIFSARFACPVCGHSISELEPKLFSFNNPAGACPTCDGLGVKQFFDARRVVNGELTLAEGAIRGWDRRNVYYFQMLGSLAQHYGFSLEEPFDELGAEHQKVVLYGSGRENVDFRYLNDRGDIVKRSHPFEGILPNLERRYRETESATVREELAKFLSTQPCPDCHGTRLRREARHVWVGDRTLPAITAMPVGEACEYAAGLSLTGRRGEIAAKILKEIRDRLQFLVNVGLDYLTLDRSADTLSGGEAQRIRLASQIGAGLVGVMYILDEPSIGLHQRDNERLLGTLTHLRNLGNTVIVVEHDEDAIRLADYVVDIGPGAGVHGGQVVAEGTPDQVMNHPDSLTGKYLSGRKKIAVPAKRTPRDKKKLLKLKGARGNNLQNVNLEIPVGLFTCITGVSGSGKSTLINNTLFPITATALNGATTLEVAPYDSFDGLQHLDKVVDIDQSPIGRTPRSNPATYTGLFTPIRELFSGVPEARSRGYGPGRFSFNVKGGRCEACQGDGVIKVEMHFLPDIYVPCDVCKGKRYNRETLEIRYKGKSIHEVLEMTIEEAREFFDAVPALARKLQTLMDVGLSYIKLGQSATTLSGGEAQRVKLSRELSKRDTGKTLYILDEPTTGLHFADIQQLLDVLHRLRDHGNTVVVIEHNLDVIKTADWLVDLGPEGGSKGGQIIANGTPEQVAEMPQSHTGHFLKPLLERDRA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70.......---.80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260--.......270.......280...-....290....-...300.......310....--....320.......330.......340.......350...-..----..360.-----......370.-......380..----.....----390.......400.......410.......420.--------......430.......440---..-----......450-----------........460...---....470.......480.......490.......500....-...510.......520.......530.......540.......550-.......560.......570.......580.......590....--------...600--.......610.......----620--.........630.......640.......650.......660--.......------..670......-------.-680.......690.......700.......710.......720.--......730.......740.......750-..------------------------------------------------------------------------------------...----------------------------..760.......770.......780.......790.......800.--------------------------......810.......820.......830.......840.......850.......860.......870.......880........890....-...900.......910.......920.......930.......940...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MD
K
I
L
I
RGARTHNLKNV
D
L
TLPRD
K
L
I
V
I
TGLSGSGKS
S
L
A
F
D
T
L
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
S
M
MEKPDVDTIEG---LSP
A
I
S
I
E
QKSTSHNPRSTVG
T
I
T
E
I
Y
D
Y
L
R
L
L
Y
A
RVGTPRCPDHDIPL
E
A
Q
T
V
S
Q
M
V
D
Q
V
L
ALPEG
S
K
L
M
L
L
A
P
V
I
R
ERKGE
H
L
A
V
F
D
E
M
R
AQ
G
F
V
R
A
RVDG
K
L
YELDEVPKL
D
K
Q
KKH
S
I
D
V
V
V
D
R
F
K
V
R
A
D
L
Q
Q
R
L
A
E
S
F
E
T
A
L
S
LAD
G
I
A
L
VAPMDEDE
D
V
E
E
I
I
F
SARFACPVCGH
S
I
S
--ELE
P
K
LFSFNNPAGACPTCDG
L
G
-
V
K
Q
F
F
D
A
R
R
VV-NG
E
L
T
L
AEGAIRGWD-RRN
V
--
Y
Y
F
Q
M
L
G
S
L
A
Q
HYGF
S
L
E
E
P
F
D
E
LGAEH
Q
K
V
V
L
YGSGRE
N
-
V
D
----
F
R
Y
LND-----RGDIVKRSH
P
-
F
E
G
I
L
P
N
L
E
R
R
----
Y
R
ETE----
S
A
T
V
R
E
E
L
A
K
F
LSTQPCPDC
H
G
T
R
L
R
R
EA
R
H
V
W
V--------GDRTL
P
A
I
TAMPV
G
E
A
C
E
----YA-----AGLSLTGR------------
R
G
E
I
A
A
K
I
L
K
E
I
R
D
---
R
L
Q
F
L
V
N
VGL
D
Y
L
T
LDRSADTLSGG
E
A
Q
R
I
R
L
A
S
Q
I
G
A
G
L
V
-
G
V
M
Y
I
LDEPSIGLHQRD
N
E
R
L
L
G
T
L
T
H
L
R
NLG
N
T
V
I
V
V
EHDE
D
A
I
R
-
L
A
D
Y
V
V
DIGPGAGVHG
G
Q
V
V
AEGT
P
D
Q
VMNHP
D
S
L
T
G
K
Y
LSGR
K
--------
K
I
AVPA--KRT
P
R
D
K
K
K
L
L
K
LKGAR----G----NN
L
Q
N
V
N
L
EI
P
V
G
L
F
T
C
I
TGVSGSGK
S
T
L
INNTL
F
P
I
T
A
T----ALNG
A
T
T
------
L
E
VAPYDS
F
D
G
-------
L
-
Q
H
L
D
K
V
VDIDQSPIGRTPRSNPATYT
G
L
F
T
P
I
R
E
L
F
SGV
P
E
A
R
S--RGYGPG
R
F
S
F
NVKG
G
R
C
E
ACQGD
G
V
I
K
V
E
-
M
H
------------------------------------------------------------------------------------FLP----------------------------DIYVPCDVCKGKRYNR
E
T
L
E
I
R
YKG
K
S
I
H
E
V
L
E
M
T
I
E
E
A
R
E
F
F
D
A
V
--------------------------
P
A
L
A
R
K
L
Q
T
L
M
D
V
G
L
S
Y
I
KLGQSATTLSGGE
A
Q
R
V
K
L
S
R
E
L
SKRDTG
K
T
L
Y
I
L
DEPTTGL
H
F
A
D
I
Q
Q
L
L
D
V
L
H
R
L
R
D-HG
N
T
V
V
V
I
EHNL
D
V
I
K
-TA
D
W
L
V
D
LGPEGGSKG
G
Q
I
I
ANG
T
P
E
Q
V
A
E
M
P
Q
SHT
G
H
F
L
K
P
L
L
E
RDRA
1
PsiBlast_PDB
95.95
62%
-94
- C2 -
3UWX
3
?
A:
[21-961]
M
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
---
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
I
V
S
G
K
K
G
T
H
A
K
T
L
E
D
I
R
K
Q
G
Y
V
R
V
R
I
D
R
E
M
R
E
L
T
G
D
I
E
L
E
K
N
K
K
H
S
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
E
G
E
----
L
L
F
S
E
K
H
A
C
P
Y
C
G
F
S
I
G
--
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
-
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
E
P------
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
-
I
Y
----
F
R
Y
T
N
D
-----
F
G
Q
V
R
E
Q
Y
I
A
-
F
E
G
V
I
P
N
V
E
R
R
----
Y
R
E
T
S
----
S
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
--------
G
G
K
H
I
G
E
V
T
A
M
S
V
T
E
A
L
A
----
F
F
-----
D
G
L
E
L
T
E
K
------------
E
A
Q
I
A
R
L
I
L
R
E
I
R
D
---
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
K
--------
F
I
P
I
P
A
--
E
R
R
-
R
P
D
G
R
W
L
E
V
V
G
A
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
----
K
L
H
R
A
K
A
-------
K
P
G
E
H
R
D
I
R
G
-------
L
-
E
H
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
--
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
-
M
H
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I
--------------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
D
R
A
2
PsiBlast_PDB
92.23
61%
-94
- C2 -
2R6F
5
?
A:
[22-961]
-
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
---
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
----------------------------------------------
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
E
G
E
----
L
L
F
S
E
K
H
A
C
P
Y
C
G
F
S
I
G
--
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
-
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
E
P------
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
-
I
Y
----
F
R
Y
T
N
D
-----
F
G
Q
V
R
E
Q
Y
I
A
-
F
E
G
V
I
P
N
V
E
R
R
----
Y
R
E
T
S
----
S
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
--------
G
G
K
H
I
G
E
V
T
A
M
S
V
T
E
A
L
A
----
F
F
-----
D
G
L
E
L
T
E
K
------------
E
A
Q
I
A
R
L
I
L
R
E
I
R
D
---
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
K
--------
F
I
P
I
P
A
--
E
R
R
-
R
P
D
G
R
W
L
E
V
V
G
A
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
----
K
L
H
R
A
K
A
-------
K
P
G
E
H
R
D
I
R
G
-------
L
-
E
H
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
--
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
-
M
H
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I
--------------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
D
R
A
114
HHSearch
91.88
62%
-94
- C2 -
2R6F
5
?
A:
[21-960]
M
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
---
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
----------------------------------------------
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
----
E
G
E
L
L
F
S
E
K
H
A
C
P
Y
C
G
F
S
I
G
--
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
-
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
E
-
P
-----
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
I
Y
F
----
R
Y
T
N
D
------
F
G
Q
V
R
E
Q
Y
I
A
-
F
E
G
V
I
P
N
V
E
R
R
----
Y
R
E
T
S
----
S
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
--------
G
G
K
H
I
G
E
V
T
A
M
S
V
T
E
A
L
A
----
F
F
-----
D
G
L
E
L
T
E
K
------------
E
A
Q
I
A
R
L
I
L
R
E
I
R
D
---
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
K
--------
F
I
P
I
P
A
--
E
R
R
-
R
P
D
G
R
W
L
E
V
V
G
A
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
----
K
L
H
R
A
-
K
------
A
K
P
G
E
H
R
D
I
R
G
-------
L
-
E
H
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
--
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
-
M
H
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I
--------------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
D
R
-
3
PsiBlast_PDB
90.93
57%
-83
- C2 -
3ZQJ
3
UVRA_MYCTU
A:
[24-970]
-
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
---
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
R
L
T
V
K
A
A
A
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
E
F
V
D
------
E
Q
R
F
S
E
K
L
A
C
P
-
N
G
H
A
L
A
VD
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
-
I
R
K
E
V
D
P
E
L
V
V
P
D
P
D
R
T
L
A
Q
G
A
V
A
P
W
S
-
N
G
H
T
A
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
R
K
L
P
A
K
A
R
K
A
I
L
E
G
A
D
-
E
Q
-
V
H
----
V
R
Y
R
N
R
-----
Y
G
R
T
R
S
Y
Y
A
D
-
F
E
G
V
L
A
F
L
Q
R
K
----
M
S
Q
T
E
----
S
E
Q
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
E
SKGEH
G
A
K
S
I
A
E
V
C
E
L
S
I
A
D
C
A
D
----
F
L
-----
N
A
L
T
L
G
P
R
------------
E
Q
A
I
A
G
Q
V
L
K
E
I
R
S
---
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
E
--------
S
I
E
I
P
A
--
I
R
R
S
V
D
P
R
R
Q
L
T
V
V
G
A
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
----
R
L
N
G
A
R
Q
------
V
P
-
G
R
H
T
R
V
T
G
-------
L
-
D
Y
L
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
--
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
---------
23
PsiBlast_CBE
87.79
57%
-82
- C2 -
3ZQJ
3
UVRA_MYCTU
B:
[24-970]
-
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
---
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
--------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
-------------
F
S
E
K
L
A
C
P
-
N
G
H
A
L
A
VD
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
-
I
R
K
E
V
D
P
E
L
V
V
P-----------
A
P
W
S
-
N
G
H
T
A
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
R
K
L
P
A
K
A
R
K
A
I
L
E
G
A
D
-
E
Q
-
V
H
----
V
R
Y
R
N
R
-----
Y
G
R
T
R
S
Y
Y
A
D
-
F
E
G
V
L
A
F
L
Q
R
K
----
M
S
Q
T
E
----
S
E
Q
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
GESKGEH
G
A
K
S
I
A
E
V
C
E
L
S
I
A
D
C
A
D
----
F
L
-----
N
A
L
T
L
G
P
R
------------
E
Q
A
I
A
G
Q
V
L
K
E
I
R
S
---
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
E
--------
S
I
E
I
P
A
--
I
R
R
S
V
D
P
R
R
Q
L
T
V
V
G
A
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
----
R
L
N
G
A
R
Q
------
V
P
-
G
R
H
T
R
V
T
G
-------
L
-
D
Y
L
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
--
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
---------
21
PsiBlast_CBE
87.09
57%
-82
- C2 -
3ZQJ
2
UVRA_MYCTU
E:
[24-970]
-
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
---
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
------
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
--------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
E
F
V
D
H
------------
L
A
C
P
-
N
G
H
A
L
A
VD
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
-
I
R
K
E
V
D
P
E
L
V
V
P
D
P
D
R
T
L
A
Q
G
A
V
A
P
W
S
-
N
G
H
T
A
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
--
L
P
A
K
A
R
K
A
I
L
E
G
A
D
-
E
Q
-
V
H
----
V
R
Y
R
N
R
-----
Y
G
R
T
R
S
Y
Y
A
D
-
F
E
G
V
L
A
F
L
Q
R
K
----
M
S
Q
T
E
----
S
E
Q
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
AKGEH---
G
A
K
S
I
A
E
V
C
E
L
S
I
A
D
C
A
D
----
F
L
-----
N
A
L
T
L
G
P
R
------------
E
Q
A
I
A
G
Q
V
L
K
E
I
R
S
---
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
E
--------
S
I
E
I
P
A
--
I
R
R
S
V
D
P
R
R
Q
L
T
V
V
G
A
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
----
R
L
N
G
A
R
Q
------
V
P
-
G
R
H
T
R
V
T
G
-------
L
-
D
Y
L
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
--
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
---------
22
PsiBlast_CBE
86.71
57%
-82
- C2 -
3ZQJ
3
UVRA_MYCTU
C:
[24-970]
-
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
---
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
------
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
----------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
------------------
L
A
C
P
-
N
G
H
A
L
A
VD
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
-
I
R
K
E
V
D
P
E
L
V
V
P---------
A
V
A
P
W
S
-
N
G
H
T
AE
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
------------
K
A
R
K
A
I
L
E
G
A
D
-
E
Q
-
V
H
----
V
R
Y
R
N
R
-----
Y
G
R
T
R
S
Y
Y
A
D
-
F
E
G
V
L
A
F
L
Q
R
K
----
M
S
Q
T
E
----
S
E
Q
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
AGH-----
G
A
K
S
I
A
E
V
C
E
L
S
I
A
D
C
A
D
----
F
L
-----
N
A
L
T
L
G
P
R
------------
E
Q
A
I
A
G
Q
V
L
K
E
I
R
S
---
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
E
--------
S
I
E
I
P
A
--
I
R
R
S
V
D
P
R
R
Q
L
T
V
V
G
A
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
----
R
L
N
G
A
R
Q
------
V
P
-
G
R
H
T
R
V
T
G
-------
L
-
D
Y
L
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
--
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
---------
113
HHSearch
75.42
43%
-76
* C2 *
2VF7
4
?
A:
[14-841]
-
G
F
V
Q
V
R
G
A
R
Q
H
N
L
K
D
I
S
V
K
V
P
R
D
A
L
V
V
F
T
G
V
S
G
S
G
K
S
S
L
A
F
G
T
L
Y
A
E
A
Q
R
R
Y
L
E
S
V
S
P
Y
A
R
R
L
F
N
Q
A
G
V
P
D
V
D
A
I
D
G
---
L
P
P
A
V
A
L
Q
Q
A
R
G
T
P
T
A
R
S
S
V
G
S
V
T
T
L
S
N
L
L
R
M
L
Y
S
R
A
G
D
Y
P
P
G
-
Q
G
I
--------------------------------------------------------------------------------------------------------------------------------------------
V
Y
A
E
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
-
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
P
-
Q
A
W
----
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
-
V
P
----
V
Y
P
G
L
T
P
A
E
T
Q
R
A
L
K
K
K
M
E
P
S
-
Y
M
G
T
F
S
S
A
R
R
H
----
V
L
H
T
F
A
NTE
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
--------
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
----
L
L
-----
R
P
Y
A
E
E
R
E
PGHAERVKNRPE
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
---
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
--------
H
T
E
P
H
---
T
P
R
--
E
P
A
G
W
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
----
H
F
G
Q
-------------
G
S
A
R
L
G
G
-------
D
L
A
Q
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-----
4
PsiBlast_PDB
66.03
41%
-67
- C2 -
2VF7
4
?
A:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
-
D
P
S
L
T
I
R
E
R
A
V
A
A
W
P
-
Q
--
A
--
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
-
V
P
V
Y
P
G
L
T
P
A
E
T
-----
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
----
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
--------
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
RP
Y
A
EEREP
G
H
A
E
R
V
K
N
------------
R
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
--------
H
T
E
-----
P
H
T
P
R
E
P
A
G
W
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
GQ-----------------------
G
S
A
R
L
G
G
D
L
-
A
Q
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-----
5
PsiBlast_PDB
65.93
41%
-67
- C2 -
2VF8
7
?
A:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
-
D
P
S
L
T
I
R
E
R
A
V
A
A
W
P
-
Q
--
A
--
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
-
V
P
V
YPG
L
T
P
A
E
T
-----
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
----
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
--------
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
A
EEREP
G
H
A
E
R
V
K
N
------------
R
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
-----------
E
-----
P
H
T
P
R
E
P
A
G
W
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
GQ-----------------------
G
S
A
R
L
G
G
D
L
-
A
Q
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
------------------------------------------------------------------------------------------
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-----
26
PsiBlast_CBE
65.90
41%
-67
- C2 -
2VF7
4
?
B:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
-
D
P
S
L
T
I
R
E
R
A
V
A
A
W
P
-
Q
--
A
--
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
-
V
P
V
Y
P
G
L
T
P
A
E
T
-----
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
----
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
--------
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
RP
Y
A
EEREP
G
H
A
E
R
V
K
N
------------
R
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
--------
H
T
E
-----
P
H
T
P
R
E
P
A
G
W
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
GQ-----------------------
G
S
A
R
L
G
G
D
L
-
A
Q
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
------------------------------------------------------------------------------------------
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-----
25
PsiBlast_CBE
65.74
41%
-67
- C2 -
2VF7
5
?
C:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
-
D
P
S
L
T
I
R
E
R
A
V
A
A
W
P
-
Q
--
A
--
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
-
V
P
V
Y
P
G
L
T
P
A
E
T
-----
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
----
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
--------
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
RP
Y
A
EEREP
G
H
A
E
R
V
K
N
------------
R
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
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P
S
A
G
L
H
P
A
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T
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A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
--------
H
T
E
-----
P
H
T
P
R
E
P
A
G
W
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
FG-------------------------
S
A
R
L
G
G
D
L
-
A
Q
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
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E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-----
24
PsiBlast_CBE
65.47
41%
-65
- C2 -
2VF8
9
?
B:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
-
D
P
S
L
T
I
R
E
R
A
V
A
A
W
P
-
Q
--
A
--
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
-
V
P
V
Y
P
G
L
T
P
A
E
T
-----
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
----
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
--------
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
A
EEREP
G
H
A
E
R
V
K
N
------------
R
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
--------
H
T
E
-----
P
H
T
P
R
E
P
A
G
W
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
GQ
P
V
N
P
D
P
E
------
D
D
E
D
P
A
D
H
T
A
G
S
A
R
L
G
G
D
L
-
A
Q
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-----
116
HHSearch
57.84
39%
-79
- C2 -
3PIH
3
UVRA_THEMA
A:
[588-912]
-
A
S
L
K
I
K
G
V
R
H
N
N
L
K
N
I
D
V
E
I
P
L
G
V
F
V
C
V
T
G
V
S
G
S
G
K
S
S
L
V
M
E
T
L
Y
P
A
L
M
N
L
L
H
K
T
----------
K
L
P
A
G
E
F
D
S
I
E
G
HEN
I
D
K
M
I
A
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
K
V
F
D
E
I
R
S
L
F
A
M
T
P
A
A
K
---------------------------------------------------------------------------------------------------------------------------------------------
A
R
--
G
Y
N
K
S
R
F
S
F
N
L
K
G
G
R
C
E
A
C
Q
G
Q
G
-
Y
V
K
-
I
E
M
L
------------------------------
F
L
-------------------------------------------------------------------------------------------------
P
D
V
Y
V
E
C
D
V
C
K
G
K
R
Y
N
R
E
T
L
E
I
T
Y
--------
K
G
K
N
I
S
D
I
L
D
M
T
V
D
E
A
L
E
----
F
F
-----
K
N
I
P
--------------------------
S
I
K
R
---
T
L
Q
V
L
H
D
V
G
L
G
Y
V
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
I
K
L
A
S
E
L
R
K
R
D
T
G
R
T
L
Y
I
L
D
E
P
T
V
G
L
H
F
E
D
V
R
K
L
V
E
V
L
H
R
L
V
D
R
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
N
A
D
H
I
I
D
L
G
P
E
G
G
K
E
G
G
Y
I
V
A
T
G
T
P
E
E
I
A
K
N
P
H
S
Y
T
G
R
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
55.93
38%
-70
- C2 -
2R6F
3
?
A:
[629-954]
--
W
L
E
V
V
G
A
R
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
A
-------
K
A
K
P
G
E
H
R
D
I
R
G
L
E
H
---
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------
V
R
--
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
-
I
I
K
-
I
E
M
H
------------------------------
F
-------------------------------------------------------------------------------------------------
L
P
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
--------
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
----
F
F
-----
A
S
I
P
--------------------------
K
I
K
R
---
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
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P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
HHSearch
55.36
35%
-69
- C2 -
2VF7
3
?
A:
[12-502]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
G
F
V
Q
V
R
G
A
R
----
Q
----
H
N
L
K
D
I
S
V
K
V
P
R
D
A
L
V
V
F
T
G
V
S
G
S
G
K
S
S
L
A
F
G
T
L
Y
A
E
A
Q
R
----
R
Y
L
E
S
V
S
PYARRL
F
N
Q
A
G
V
P
D
V
D
A
-------
I
-
D
G
L
P
P
A
V
A
L
Q
Q
A
R
G
T
P
T
A
R
S
S
V
G
S
V
T
T
L
S
N
L
L
R
M
L
Y
S
R
A
G
D
Y
P
P
GQ
G
I
V
Y
A
E
G
F
S
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T
P
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G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
SMVPDPSLTIRERAVAAWPQA
W
G
G
Q
N
Q
R
D
I
L
V
T
L
GIDVDVPWRELP
E
E
T
R
H
W
I
L
FTD
E
Q
P
V
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
K
KMEPS
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
NTES
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
AEEREPGHAERVKNRPE
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
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Q
L
Y
S
N
L
-
F
G
V
V
Y
V
L
D
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P
S
A
G
L
H
P
A
D
T
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A
L
L
S
A
L
E
N
L
K
R
-
G
G
N
S
L
F
V
V
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H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
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A
G
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K
G
G
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L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
---------
121
HHSearch
47.29
25%
-53
- C2 -
1YQT
4
?
A:
[144-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
E
L
E
N
V
-
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
---
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
Y
G
E
P
G
V
Y
G
I
F
S
Q
P
K
G
T
R
N
G
I
N
----
E
F
L
R
G
Y
L
K
D
E
N
VRFRP
Y
E
I
K
F
T
K
T
G
--
E
R
V
E
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
YG
S
----
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
--------------------------
T
E
G
-------
K
-------
I
E
W
D
L
T
V
-
A
---------
Y
---
K
P
Q
Y
I
K
A
-----------------
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
T
V
Y
E
L
L
S
K
I
D
A
------
S
K
L
--------------------------
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
----------------------------------------
118
HHSearch
47.23
26%
-52
- C2 -
3BK7
2
?
A:
[212-546]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
K
E
L
E
L
E
N
V
-
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
---
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
G
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
Y
G
E
P
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
I
N
E
----
F
L
Q
G
Y
L
K
D
E
N
VRFRP
Y
--
E
I
R
F
T
K
LS
E
R
V
D
V
E
R
E
T
L
V
E
Y
P
R
L
V
----
K
D
YGS
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
--------------------------
T
E
G
-------
K
-------
V
E
W
D
L
T
-
V
A
Y
K
P
Q
-----------
Y
I
K
A
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
T
V
Y
E
L
L
S
K
I
D
S
S
K
--
L
-
N
-----------------------------
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
----------------------------------------
137
Fugue
46.03
62%
-79
* C5 *
4DFC
-
UVRA_ECOLI
B:
[128-250]
----------------------------------------------------------------------------------------------------------------------------------
M
A
S
T
V
S
Q
M
V
D
N
V
L
S
Q
P
E
G
K
R
L
M
L
L
A
P
I
I
K
E
R
K
G
E
H
T
K
T
L
E
N
L
A
S
Q
G
Y
I
R
A
R
I
D
G
E
V
C
D
L
S
D
P
P
K
L
E
L
Q
K
K
H
T
I
E
V
V
V
D
R
F
K
V
R
--
L
T
Q
R
L
A
E
S
F
E
T
A
L
E
L
S
G
G
T
A
V
V
A
D
M
D
-
D
P
K
A
E
E
L
L
F
S
A
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
45.91
62%
-79
- C5 -
4DFC
-
UVRA_ECOLI
B:
[128-249]
----------------------------------------------------------------------------------------------------------------------------------
M
A
S
T
V
S
Q
M
V
D
N
V
L
S
Q
P
E
G
K
R
L
M
L
L
A
P
I
I
K
E
R
K
G
E
H
T
K
T
L
E
N
L
A
S
Q
G
Y
I
R
A
R
I
D
G
E
V
C
D
L
S
D
P
P
K
L
E
L
Q
K
K
H
T
I
E
V
V
V
D
R
F
K
V
R
--
L
T
Q
R
L
A
E
S
F
E
T
A
L
E
L
S
G
G
T
A
V
V
A
D
M
D
-
D
P
K
A
E
E
L
L
F
S
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------