@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4270: (2016-02-25 )
MAYSYTEKKRIRKDFSKLPDVMDVPYLLAIQLDSYREFLQAGATKEQFRDVGLHAAFKSVFPIISYSGNAALEYVGYRLGEPAFDVKECVLRGVTFAVPLRVKVRLIIFDRESSNKAIKDIKEQEVYMGEIPLMTENGTFIINGTERVIVSQLHRSPGVFFDHDRGKTHSSGKLLYSARIIPYRGSWLDFEFDPKDCVFVRIDRRRKLPASVLLRALGYSTEEILNAFYATNVFHIKGETLNLELVPQRLRGEVASIDIKDGSGKVIVEQGRRITARHINQLEKAGVSQLEVPFDYLIGRTIAKAIVHPATGEIIAECNTELTLDLLAKVAKAQVVRIETLYTNDIDCGPFISDTLKIDNTSNQLEALVEIYRMMRPGEPPTKEAAETLFGNLFFSAERYDLSAVGRMKFNRRIGRTEIEGPGVLSKEDIIDVLKTLVDIRNGKGIVDDIDHLGNRRVRCVGEMAENQFRVGLVRVERAVKERLSMAESEGLMPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLATYARTNKYGFLESPYRVVKDSLVTDEIVFLSAIEEADHVIAQASATLNEKGQLVDELVAVRHLNEFTVKAPEDVTLMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMERNVARDSGVCVVARRGGVIDSVDASRVVVRVADDEVETGEAGVDIYNLTKYTRSNQNTCINQRPLVSKGDVVARGDILADGPSTDMGELALGQNMRVAFMPWNGFNFEDSICLSERVVQEDRFTTIHIQELTCVARDTKLGPEEITADIPNVGEAALNKLDEAGIVYVGAEVQAGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPTGTKGTVIDVQVFTRDGVERDSRALSIEKMQLDQIRKDLNEEFRIVEGATFERLRAALVGAKAEGGPALKKGTEITDDYLDGLERGQWFKLRMADDALNEQLEKAQAYISDRRQLLDDKFEDKKRKLQQGDDLAPGVLKIVKVYLAIKRRIQPGDKMAGRHGNKGVVSVIMPVEDMPHDANGTPVDIVLNPLGVPSRMNVGQILETHLGLAAKGLGEKINRMLEEQRKVAELRKFLHEIYNEIGGREENLDELGDNEILALAKNLRGGVPMATPVFDGAKEREIKAMLKLADLPESGQMRLFDGRTGNQFERPTTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGDHRMEAGMPESFNVLIKEIRSLGIDIELETE
Atome Classification :
(46 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......-------430.......440.--......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940-........950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170-........1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAYS
Y
T
E
K
K
R
I
R
K
D
F
S
KLPDVMDV
P
Y
L
L
A
I
Q
L
D
S
Y
R
E
F
L
QAGA
T
K
E
Q
F
R
D
V
G
L
H
A
A
F
K
S
V
F
P
I
I
SYSG
N
A
A
L
E
Y
V
G
Y
RLGEPA
F
D
V
K
E
C
V
L
RG
V
T
F
A
V
P
L
R
V
K
V
R
L
I
I
F
DRESS
N
K
A
I
K
D
I
K
E
QEVYMGEI
P
L
M
TEN
G
T
F
I
ING
T
E
R
V
I
V
S
Q
L
HRSPG
V
F
F
DHDRGKTHSS
G
K
L
L
Y
S
A
R
IIPYRG
S
W
L
D
F
EFDPK
D
C
V
F
V
R
IDRRRKL
P
A
S
V
L
L
R
A
LGY
S
T
E
E
I
L
N
A
F
Y
AT
N
V
F
H
IKG
E
T
L
N
L
E
LV
P
Q
R
LRGE
V
A
S
I
D
IKDGS
G
K
V
I
V
EQGR
R
I
T
A
R
H
I
N
Q
L
E
K
AGVSQLE
V
P
F
D
Y
L
I
G
R
T
I
A
K
A
I
VHPAT
G
E
I
I
AECNTE
L
T
L
D
L
L
A
K
V
A
K
A
Q
V
V
R
I
E
T
L
YTNDIDCGPFIS
D
T
L
K
IDNT
S
N
Q
L
E
A
L
V
E
I
Y
R
M
MRPGEP
P
T
K
E
A
A
E
T
L
F
G
N
L
F
F
S
AERY
D
L
S
A
V
G
R
M
K
F
NRRIGRTEIEGPGVL
S
K
E
D
-------
I
I
D
V
L
K
T
L
V
D
IRNG--KG
I
V
D
D
I
D
H
LGNRR
V
R
C
V
G
E
M
AEN
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
M
A
E
SEGLM
P
Q
D
LINA
K
P
V
A
A
A
I
K
E
F
F
G
S
S
Q
L
S
Q
F
M
DQNN
P
L
S
E
I
T
H
K
R
RVSALGPGGLTRERAG
F
E
V
R
DVHPTHYGRVCPIETPEGPNI
G
L
I
N
S
L
A
T
Y
A
RTNKYGFLES
P
Y
R
V
V
K
DSLVT
D
E
I
V
F
L
S
A
I
E
E
A
D
H
V
I
A
Q
A
SATLN
E
K
G
Q
L
V
D
E
L
V
A
V
R
H
L
N
E
FTVKAPE
D
V
T
L
MDV
S
P
K
Q
V
V
S
V
A
A
S
L
I
P
F
LEHDDANRALMGSN
M
Q
R
QAVPTLRADKPLVGTGMERNVARDS
G
V
C
V
V
ARRGGVIDSVDA
S
R
V
V
V
R
VADDEVETGEAG
V
D
I
Y
N
L
T
K
YTRSNQNTCINQRPLVSKG
D
V
V
A
RG
D
I
LADGPST
D
M
G
E
LALGQN
M
R
V
A
F
MPWNGFNFE
D
S
I
C
L
S
E
R
V
VQEDR
F
T
T
I
H
I
Q
E
L
T
C
V
ARDTKL
G
P
E
E
I
TADIPNV
G
E
A
A
L
N
KLDEA
G
I
V
Y
VG
A
E
V
QAG
D
I
L
V
G
K
VTPKGETQLT
P
E
E
K
L
L
R
A
I
FGEKASDVKDT
S
L
RVPTGTK
G
T
V
I
D
V
Q
V
F
TR--DGVERDSRAL
S
I
E
K
M
Q
L
D
Q
I
R
K
D
L
N
E
E
F
R
IVEGA
T
F
E
R
L
R
A
A
L
VGAKAEGGPALKKGTEI
T
D
D
Y
L
D
GLERG
Q
W
F
K
L
R
MA
D
D
A
L
N
E
Q
L
E
K
A
Q
A
Y
I
S
D
R
R
Q
L
L
D
D
K
F
E
D
K
K
R
K
LQQGDDL
A
P
G
V
L
K
I
V
K
V
Y
L
A
I
K
R
RIQPGD
K
M
AGRHGNK
G
V
V
S
V
I
MPVEDMPHDANG
T
P
V
D
I
V
L
NPLGVPSRM
N
V
G
Q
I
L
E
T
H
L
G
L
A
A
K
G
L
G
E
K
I
N
R
M
L
E
E
Q
R
K
V
A
E
L
R
K
F
L
H
E
I
Y
N
E
IGG---REE
N
L
D
E
LGD
N
E
I
L
A
L
A
K
NLRGGVPMATPVFDG
A
K
E
R
E
I
K
A
M
L
K
L
ADLPESG
Q
M
R
L
FDGRTGNQFERPTT
V
G
Y
M
Y
M
L
K
L
N
H
LVDDKMHARSTG
S
Y
S
L
V
TQQPLGGKAQFGGQRFGE
M
E
V
W
A
L
EAYG
A
A
Y
T
L
Q
E
M
L
T
VKSDDVN
G
R
T
K
M
Y
K
N
IVDGDHRMEAGMP
E
S
F
N
V
L
I
K
E
I
R
SLG
I
D
I
E
L
ETE
11
PsiBlast_PDB
87.01
73%
-79
- C5 -
4LLG
-
?
C:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
-------
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
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N
Q
F
R
V
G
L
V
R
V
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R
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K
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L
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G
D
L
D
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M
P
Q
D
M
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N
A
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P
I
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A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
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S
A
L
G
P
G
G
L
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R
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P
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I
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K
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D
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K
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Q
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L
V
A
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G
V
E
A
------------
E
K
L
D
K
L
P
R
D
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W
L
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L
G
L
T
D
E
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K
Q
N
Q
L
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Q
L
A
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Q
Y
D
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K
H
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F
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K
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A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
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K
I
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P
I
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D
M
P
Y
D
E
N
G
T
P
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D
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V
L
N
P
L
G
V
P
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M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
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L
L
K
L
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Q
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L
Y
D
G
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G
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T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
17
PsiBlast_PDB
86.79
73%
-79
- C5 -
4YG2
1
RPOB_ECOLI
C:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
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R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
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K
G
R
R
I
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A
R
H
I
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Q
L
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K
L
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P
V
E
Y
I
A
G
K
V
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T
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L
I
C
A
A
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M
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L
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L
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L
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L
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H
K
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L
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Y
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M
M
R
P
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A
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L
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L
F
F
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Y
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L
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G
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M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
-------
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
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L
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L
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L
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L
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V
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I
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Y
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A
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Y
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A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
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C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
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T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
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A
V
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A
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A
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G
G
V
V
Q
Y
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Y
P
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A
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Y
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N
Q
N
T
C
I
N
Q
M
P
C
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L
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P
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R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
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K
G
E
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Q
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T
P
E
E
K
L
L
R
A
I
F
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K
A
S
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V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
--
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
G
V
E
A
------------
E
K
L
D
K
L
P
R
D
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
30
PsiBlast_CBE
86.72
73%
-79
- C5 -
4YG2
1
RPOC_ECOLI
I:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
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P
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R
L
R
G
E
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A
S
F
D
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E
A
N
G
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K
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M
M
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A
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L
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G
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K
F
N
R
S
L
L
R
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E
I
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G
I
L
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D
D
-------
I
I
D
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M
K
K
L
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R
N
G
--
K
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D
D
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Q
F
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V
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D
K
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A
V
L
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A
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A
------------
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R
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L
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L
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F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
13
PsiBlast_PDB
86.53
73%
-78
- C5 -
4MEY
-
RPOB_ECOLI
C:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
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V
Q
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C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
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L
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A
P
E
G
T
V
K
D
I
K
E
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M
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L
M
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F
V
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L
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P
G
V
F
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S
G
K
V
L
Y
N
A
R
I
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Y
R
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W
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F
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F
D
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K
D
N
L
F
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R
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K
L
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A
T
I
I
L
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A
L
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Y
T
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A
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L
L
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D
D
-------
I
I
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K
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N
G
--
K
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D
D
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K
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A
V
L
V
A
G
G
V
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A
------------
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R
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R
W
L
E
L
G
L
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Y
D
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T
Q
G
D
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A
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A
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L
R
K
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M
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A
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A
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I
K
E
L
L
K
L
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D
L
P
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G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
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P
V
T
V
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Y
M
Y
M
L
K
L
N
H
L
V
D
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L
L
K
E
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R
S
L
G
I
N
I
E
L
E
D
E
10
PsiBlast_PDB
86.52
73%
-79
- C5 -
4LK1
-
?
C:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
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N
S
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Y
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G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
24
PsiBlast_CBE
86.50
73%
-79
- C5 -
4ZH3
1
?
C:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
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H
K
R
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L
F
T
N
D
L
D
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G
P
Y
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T
L
R
V
D
P
T
N
D
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L
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A
L
V
E
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Y
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M
M
R
P
G
E
P
P
T
R
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A
A
E
S
L
F
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N
L
F
F
S
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D
R
Y
D
L
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A
V
G
R
M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
-------
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
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N
Q
F
R
V
G
L
V
R
V
E
R
A
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K
E
R
L
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L
G
D
L
D
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L
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P
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D
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D
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P
N
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L
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A
Q
T
N
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F
L
E
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K
V
T
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G
V
V
T
D
E
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Y
L
S
A
I
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N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
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T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
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A
V
D
S
G
V
T
A
V
A
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R
G
G
V
V
Q
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Y
P
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Y
T
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N
Q
N
T
C
I
N
Q
M
P
C
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G
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P
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G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
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A
S
D
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K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
--
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
G
V
E
A
------------
E
K
L
D
K
L
P
R
D
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
25
PsiBlast_CBE
86.47
73%
-79
- C5 -
4ZH2
1
?
I:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
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F
D
I
-
E
A
N
G
K
V
Y
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K
G
R
R
I
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A
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D
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I
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C
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N
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L
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M
M
R
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P
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R
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A
A
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L
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L
F
F
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Y
D
L
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G
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M
K
F
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R
S
L
L
R
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E
I
E
G
S
G
I
L
S
K
D
D
-------
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
G
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D
D
I
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R
R
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F
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R
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A
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L
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G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
15
PsiBlast_PDB
86.46
73%
-81
- C5 -
4YFN
1
RPOB_ECO24
C:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
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D
D
V
K
L
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V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
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T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
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K
L
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H
K
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T
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D
L
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P
Y
I
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L
R
V
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N
D
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A
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Y
R
M
M
R
P
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P
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A
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L
F
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N
L
F
F
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Y
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L
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G
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M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
-------
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
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V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
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A
V
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L
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L
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D
L
D
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L
M
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A
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F
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F
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L
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A
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N
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Y
G
F
L
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Y
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V
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D
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I
H
Y
L
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A
I
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N
Y
V
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A
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A
N
S
N
L
D
E
E
G
H
F
V
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D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
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A
D
K
P
L
V
G
T
G
M
E
R
A
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A
V
D
S
G
V
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A
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A
K
R
G
G
V
V
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Y
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Y
P
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Y
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N
T
C
I
N
Q
M
P
C
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P
V
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R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
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D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
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P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
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A
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V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
--
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
G
V
E
A
------------
E
K
L
D
K
L
P
R
D
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
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Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
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M
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I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
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K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
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M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
23
PsiBlast_CBE
86.45
73%
-79
- C5 -
4ZH3
1
?
I:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
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R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
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I
R
D
N
K
L
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M
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L
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P
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R
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A
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M
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L
F
F
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R
S
L
L
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L
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D
-------
I
I
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M
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K
L
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N
G
--
K
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D
D
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R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
22
PsiBlast_CBE
86.45
73%
-79
- C5 -
4ZH4
1
?
C:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
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Y
E
R
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A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
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I
P
L
M
T
D
N
G
T
F
V
I
N
G
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R
V
I
V
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Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
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K
V
I
F
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R
D
N
K
L
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M
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L
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P
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L
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A
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F
D
I
-
E
A
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G
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L
L
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D
D
-------
I
I
D
V
M
K
K
L
I
D
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N
G
--
K
G
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D
D
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R
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F
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A
S
L
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A
N
M
Q
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A
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M
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A
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M
P
W
N
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Y
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V
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L
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P
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A
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A
A
L
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K
L
D
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V
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--
D
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K
D
K
R
A
L
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E
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Q
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K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
G
V
E
A
------------
E
K
L
D
K
L
P
R
D
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
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G
N
K
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I
S
K
I
N
P
I
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D
M
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N
G
T
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V
D
I
V
L
N
P
L
G
V
P
S
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M
N
I
G
Q
I
L
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T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
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D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
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V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
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A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
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G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
31
PsiBlast_CBE
86.44
73%
-81
- C5 -
4YFN
1
RPOB_ECO24
I:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
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Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
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Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
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V
I
V
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Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
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S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
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I
R
D
N
K
L
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M
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L
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P
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R
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A
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M
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L
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F
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R
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L
L
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D
-------
I
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K
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K
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D
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A
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A
------------
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L
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D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
32
PsiBlast_CBE
86.42
73%
-79
- C5 -
4YFK
2
RPOB_ECO24
I:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
-------
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
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N
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K
P
I
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A
A
V
K
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F
F
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L
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N
N
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L
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T
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K
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R
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L
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G
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A
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F
E
V
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D
V
H
P
T
H
Y
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C
P
I
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T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
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V
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E
D
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M
Y
P
G
E
A
G
I
D
I
Y
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T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
--
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
G
V
E
A
------------
E
K
L
D
K
L
P
R
D
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
21
PsiBlast_CBE
86.40
73%
-78
- C5 -
4ZH4
1
?
I:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
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K
G
R
R
I
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A
R
H
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L
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D
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I
A
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C
A
A
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M
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L
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K
L
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T
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L
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V
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P
T
N
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R
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A
L
V
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R
M
M
R
P
G
E
P
P
T
R
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A
A
E
S
L
F
E
N
L
F
F
S
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D
R
Y
D
L
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A
V
G
R
M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
-------
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
G
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D
D
I
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R
R
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L
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--
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A
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A
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A
------------
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L
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Q
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L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
9
PsiBlast_PDB
86.40
73%
-81
- C5 -
4LK0
-
?
C:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
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R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
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K
V
I
F
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I
R
D
N
K
L
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M
E
L
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P
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L
R
G
E
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A
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F
D
I
-
E
A
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G
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V
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K
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I
A
G
K
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L
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A
A
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M
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L
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L
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L
L
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L
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L
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D
L
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L
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V
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A
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M
M
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P
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A
A
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L
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L
F
F
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D
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D
L
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G
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M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
-------
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
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A
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L
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L
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D
L
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L
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L
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Y
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A
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A
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S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
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Y
P
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E
A
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S
N
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N
T
C
I
N
Q
M
P
C
V
S
L
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P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
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Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
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K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
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D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
--
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
G
V
E
A
------------
E
K
L
D
K
L
P
R
D
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
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M
N
I
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Q
I
L
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T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
D
V
R
Q
K
V
D
L
S
T
F
S
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E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
36
PsiBlast_CBE
86.37
73%
-79
- C5 -
4XSY
1
?
C:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
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I
R
D
N
K
L
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M
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L
V
P
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L
R
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E
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A
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D
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A
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G
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M
M
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L
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F
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R
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L
L
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L
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D
D
-------
I
I
D
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M
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K
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N
G
--
K
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D
D
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A
------------
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I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
37
PsiBlast_CBE
86.35
73%
-81
- C5 -
4XSX
1
?
I:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
-------
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
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S
Q
L
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N
N
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T
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R
R
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P
G
G
L
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R
A
G
F
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V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
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V
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E
D
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M
Y
P
G
E
A
G
I
D
I
Y
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K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
--
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
G
V
E
A
------------
E
K
L
D
K
L
P
R
D
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
26
PsiBlast_CBE
86.34
73%
-79
- C5 -
4ZH2
1
?
C:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
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K
G
R
R
I
T
A
R
H
I
R
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L
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K
D
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L
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I
A
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C
A
A
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L
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L
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P
T
N
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A
L
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M
M
R
P
G
E
P
P
T
R
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A
A
E
S
L
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N
L
F
F
S
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D
R
Y
D
L
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A
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G
R
M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
-------
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
G
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V
D
D
I
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L
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N
R
R
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F
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R
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D
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--
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A
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A
------------
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L
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I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
35
PsiBlast_CBE
86.33
73%
-79
- C5 -
4XSY
1
?
I:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
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R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
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R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
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V
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K
G
R
R
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A
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H
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D
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V
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Y
I
A
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K
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C
A
A
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M
M
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L
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L
F
F
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M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
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K
D
D
-------
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
G
E
V
D
D
I
D
H
L
G
N
R
R
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V
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A
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Q
F
R
V
G
L
V
R
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D
L
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Y
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N
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D
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E
G
H
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K
G
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S
S
L
F
S
R
D
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M
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T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
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D
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A
N
R
A
L
M
G
A
N
M
Q
R
Q
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V
P
T
L
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K
P
L
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G
T
G
M
E
R
A
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A
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A
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R
G
G
V
V
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Y
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Y
P
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N
T
C
I
N
Q
M
P
C
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G
D
V
L
A
D
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P
S
T
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L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
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I
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V
S
E
R
V
V
Q
E
D
R
F
T
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H
I
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A
C
V
S
R
D
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K
L
G
P
E
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A
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I
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N
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G
E
A
A
L
S
K
L
D
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T
G
G
D
I
L
V
G
K
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K
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E
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K
L
L
R
A
I
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S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
--
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
G
V
E
A
------------
E
K
L
D
K
L
P
R
D
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
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N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
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M
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I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
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K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
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A
R
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T
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Y
S
L
V
T
Q
Q
P
L
G
G
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A
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F
G
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M
E
V
W
A
L
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A
Y
G
A
A
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T
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M
L
T
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K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
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S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
8
PsiBlast_PDB
86.27
73%
-79
- C5 -
4LJZ
-
?
C:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
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Q
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C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
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I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
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Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
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V
I
V
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Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
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G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
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F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
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I
L
D
L
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F
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K
V
I
F
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R
D
N
K
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A
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M
M
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L
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F
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F
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R
S
L
L
R
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D
D
-------
I
I
D
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M
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K
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N
G
--
K
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D
D
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F
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A
------------
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L
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Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
12
PsiBlast_PDB
86.24
73%
-77
- C5 -
4MEX
1
RPOB_ECOLI
C:
[3-1342]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
----
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
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V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
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T
L
F
T
N
D
L
D
H
G
P
Y
I
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L
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V
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T
N
D
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L
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A
L
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Y
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M
M
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P
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E
P
P
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A
A
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L
F
E
N
L
F
F
S
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D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
-------
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
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L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
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A
A
V
K
E
F
F
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L
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Q
N
N
P
L
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I
T
H
K
R
R
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A
L
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G
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L
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L
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A
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V
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I
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Y
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A
I
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N
Y
V
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A
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A
N
S
N
L
D
E
E
G
H
F
V
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D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
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T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
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K
P
L
V
G
T
G
M
E
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A
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A
V
D
S
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A
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R
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G
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V
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D
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Y
P
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D
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Y
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N
T
C
I
N
Q
M
P
C
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P
V
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G
D
V
L
A
D
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P
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T
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L
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E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
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D
S
I
L
V
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E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
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L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
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G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
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K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
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V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
--
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
G
V
E
A
------------
E
K
L
D
K
L
P
R
D
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
49
PsiBlast_CBE
58.66
51%
-52
- C5 -
4OIQ
3
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
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F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
58.17
51%
-49
- C5 -
4G7H
2
RPOB_THET8
M:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
GEFKDEV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
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V
G
E
L
M
T
D
Q
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G
L
A
R
L
A
R
G
V
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R
M
L
M
G
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S
L
T
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A
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L
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P
L
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F
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L
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L
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H
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R
R
I
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A
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G
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G
G
L
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F
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D
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H
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H
Y
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R
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A
N
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G
L
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R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
58.05
51%
-49
- C5 -
4G7O
3
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
58.02
51%
-48
- C5 -
4G7O
3
RPOB_THET8
M:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
GEFKDEV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
57.86
51%
-51
- C5 -
4OIN
3
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
57.85
51%
-49
- C5 -
4OIP
3
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
EV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
57.78
51%
-49
- C5 -
4G7Z
2
RPOB_THET8
M:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
GEFKDEV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
57.77
51%
-50
- C5 -
4G7H
1
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
57.65
51%
-49
- C5 -
4OIR
4
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
EV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
57.60
51%
-50
- C5 -
4Q4Z
4
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
57.48
51%
-50
- C5 -
4MQ9
2
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
----D
E
V
----
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
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A
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V
V
M
T
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R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
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-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
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P
A
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E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
57.47
51%
-49
- C5 -
4OIO
5
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
57.25
51%
-48
- C5 -
4G7Z
2
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
56.62
51%
-47
- C5 -
4Q5S
4
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
55.39
51%
-45
- C5 -
3AOI
2
RPOB_THET8
M:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
GEFKDEV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
----------------------
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
55.29
51%
-41
- C5 -
3AOH
2
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
GEFKDEV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
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A
N
I
G
L
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T
S
L
A
A
Y
A
R
V
D
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L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
55.20
51%
-41
- C5 -
2O5I
3
RPOB_THET8
M:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
GEFKDEV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
55.19
51%
-41
- C5 -
2O5I
3
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
GEFKDEV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
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A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
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D
E
V
V
Y
M
T
A
T
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E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
54.80
51%
-40
- C5 -
2O5J
5
RPOB_THET8
M:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
GEFKDEV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
54.70
51%
-43
- C5 -
3AOI
2
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
GEFKDEV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
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D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
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R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
-----------------------
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
54.39
51%
-37
- C5 -
2PPB
6
RPOB_THET8
M:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
GEFKDEV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
54.35
51%
-39
- C5 -
4WQS
2
RPOB_THET8
M:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
GEFKDEV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
54.33
51%
-40
- C5 -
2PPB
4
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
GEFKDEV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
54.18
51%
-39
- C5 -
2O5J
4
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
E
D
GEFKDEV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
GD
P
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
53.99
51%
-39
- C5 -
4WQS
2
RPOB_THET8
C:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
-
I
R
L
S
G
R
T
L
A
R
F
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D
GEFKDEV
F
L
P
T
L
R
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L
F
A
L
T
A
G
VP
G
H
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D
D
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R
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-
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L
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A
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A
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V
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E
D
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R
L
V
E
-------
Y
P
L
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R
F
Y
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N
Q
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T
A
L
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Q
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P
R
V
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V
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Y
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A
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A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
53.62
51%
-41
- C5 -
3AOI
1
RPOB_THET8
H:
[233-832]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
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Y
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L
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A
D
P
R
R
Y
D
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E
A
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A
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E
K
L
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-
I
R
L
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R
T
L
A
R
F
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D
GEFKDEV
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
H
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D
D
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L
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N
R
R
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R
T
--------------------------
K
D
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K
P
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V
R
V
Y
V
A
Q
K
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------