@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4316: (2016-02-26 )
MTVNASIFWYDYETTGIDPRRDRPLQIAGIRTDEALNEIGEPMNLYCRPSDDILPHPMACLITGITPQRLAERGLSEADFMTRVHAQLAQPATCVAGYNSLRFDDEVTRYSLYRNFFDPYAREWQGGNSRWDLIDMVRTAYALRPEGIQWPQLDGRLSLKLEMLTAANGLEHGQAHDALSDVRATIALARLIRQRQPRLYDYLYQLRSKHKVLDQVRLLQPLVHVSGRFSAERHFLSVVLPLAWHPRNRNALIVCDLCADPAPLLELSAEDLRRRLYTRRDELAEGELPVPLKQIQVNRCPVVAPLSVLRAEDRQRTGIELDECQQKAELLRQHQTVWADKLTALYGEESFSASDDPEQQLYDGFIGDRDRRLCEQLRLAEPEQLAKEQWPFDDARLQELFFRYRARNFPETLNVAERQQWESFCRNRLSHEEYGAPNTLPAFEAALEACRQEQGGTLPAVLAAWRDYAAELRQRYSLET
Atome Classification :
(20 SA)
.........10....---....--20.---........30...----------------.------------------....-40-.--------........50..--..---------....60..---..-....70-.-..--.....80..-......-----90------.-----........100-------..---...-.-..110...------....120.......130.......140.......150.-......160----.......170.--.......-180.......190.......200...---....210......--.220.......230.......240.....--..250...----....260.......270..----.....280-----------.........290.......300.......310---------------------........320.......330-----------.........340......-.350.......360.......370.......380.......390....-...400.......410.......420......---------.430.......440.......450....--...460.......470.......480-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
V
N
A
S
I
F
W
Y
DYETT---GIDP--R-R---DRP
L
Q
I
AGIR
T
D
E
----------------
A
------------------
L
N
E
I-G--E--------P
M
N
L
Y
CRPSDDI--LP---------H
P
M
A
C
L
IT---GI-
T
P
Q
R
L
A
-
E
-RG--L
S
E
A
D
F
M
T
R
-
V
H
A
Q
LA-----Q-------P-----
A
T
C
VAGYNSL--------RF---DD
E
-
V
-
T
R
Y
S
L
Y
R
N
------
F
F
D
P
Y
A
R
EWQGGNSR
W
D
L
I
D
M
V
R
T
A
YALRPEGIQWPQL-D
G
R
L
S
L
K
L
E
----
M
L
TAANGLE-H--G
Q
A
H
D
A
L
-
S
D
V
R
A
T
I
A
L
A
R
L
I
R
QRQ
P
R
L
Y
D
Y
L
Y
Q
---
L
R
S
K
H
K
V
L
D
Q
V
R
L
--
L
Q
P
L
V
H
VSGRF
S
A
E
R
H
F
L
S
V
V
L
P
LAWHPR--NR
N
A
L
I
V
C
----DLCADP
A
P
L
L
EL
S
A
E
D
L
R
R
----
R
L
Y
T
R
R
-------------
D
ELAEGELPV
P
L
K
Q
I
QVNRCPVV
A
P
L
S
V
L
R
A----------------------EDRQRTGI
E
L
D
E
C
Q
Q
K
A
E
L
-------------
L
R
Q
H
Q
T
V
W
A
D
K
L
T
A
L
YGE-ESFSASD
D
P
E
Q
Q
L
Y
D
G
FIG
D
R
D
R
R
L
C
E
Q
LRLA
E
P
E
Q
L
A
K
E
QWPF
D
D
A
R
-
L
Q
E
L
F
F
R
Y
R
ARNFPETL
N
V
A
E
R
Q
Q
W
E
S
F
C
R
NR---------L
S
H
E
EYGAPNT
L
P
A
F
E
A
A
L
E
A
C
R
Q
EQGG--
T
L
P
A
V
L
A
A
W
R
D
Y
A
A
E
L
R
Q
RYSLET-------------
41
Fugue
99.88
48%
-98
- C7 -
1FXX
3
EX1_ECOLI
A:
[8-477]
---
Q
S
T
F
L
F
H
D
Y
E
T
F
---
G
T
H
P
--
A
-
L
---
D
R
P
A
Q
F
A
A
I
R
T
D
S
----------------
E
------------------
F
N
V
I
-
G
--
E
--------
P
E
V
F
Y
C
K
P
A
D
D
Y
--
L
P
---------
Q
P
G
A
V
L
I
T
---
G
I
-
T
P
Q
E
A
R
-
A
-
K
G
--
E
N
E
A
A
F
A
A
R
-
I
H
S
L
F
T
-----
V
-------
P
-----
K
T
C
I
L
G
Y
N
N
V
--------
R
F
---
D
D
E
-
V
-
T
R
N
I
F
Y
R
N
------
F
Y
D
P
Y
A
W
S
W
Q
H
D
N
S
R
W
D
L
L
D
V
M
R
A
C
Y
A
L
R
P
E
G
I
N
W
P
E
---
G
L
P
S
F
R
L
E
----
H
L
T
K
A
N
G
I
E
-
H
--
S
N
A
H
D
A
M
-
A
D
V
Y
A
T
I
A
M
A
K
L
V
K
T
R
Q
P
R
L
F
D
Y
L
F
T
---
H
R
N
K
H
K
L
M
A
L
I
D
V
PQ
M
K
P
L
V
H
V
S
G
M
F
G
A
W
R
G
N
T
S
W
V
A
P
L
A
W
H
P
E
--
N
R
N
A
V
I
M
V
----
D
L
A
G
D
I
S
P
L
L
E
L
D
S
D
T
L
R
E
----
R
L
Y
T
A
K
-------------
T
D
L
-----
A
V
P
V
K
L
V
H
I
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
----------------------
E
D
A
D
R
L
G
I
N
R
Q
H
C
L
D
N
L
K
I
-------------
L
R
E
-
N
P
Q
V
R
E
K
V
V
A
I
F
A
E
-
A
P
---
S
D
N
V
D
A
Q
L
Y
N
G
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
-
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
L
E
H
R
R
Q
V
---------
F
T
------
P
E
F
L
Q
G
Y
A
D
E
L
Q
M
L
V
Q
Q
Y
A
D
D
K
E
K
V
A
L
L
K
A
L
W
Q
Y
A
D
E
I
V
E
H
------------------
16
PsiBlast_CBE
94.88
50%
-95
- C7 -
4HCC
8
EX1_ECOLI
B:
[9-427]
----
S
T
F
L
F
H
D
Y
E
T
F
---
G
T
H
P
--
A
-
L
---
D
R
P
A
Q
F
A
A
I
R
T
D
S
----------------
E
------------------
F
N
V
I
-
G
--
E
--------
P
E
V
F
Y
C
K
P
A
D
D
Y
--
L
P
---------
Q
P
G
A
V
L
I
T
---
G
I
-
T
P
Q
E
A
R
-
A
-
K
G
--
E
N
E
A
A
F
A
A
R
-
I
H
S
L
F
T
-----
V
-------
P
-----
K
T
C
I
L
G
Y
N
N
V
--------
R
F
---
D
D
E
-
V
-
T
R
N
I
F
Y
R
N
------
F
Y
D
P
Y
A
W
S
W
Q
H
D
N
S
R
W
D
L
L
D
V
M
R
A
C
Y
A
L
R
P
E
G
I
N
W
P
E
N
---
L
P
S
F
R
L
E
----
H
L
T
K
A
N
G
I
E
-
H
--
S
N
A
H
D
A
M
-
A
D
V
Y
A
T
I
A
M
A
K
L
V
K
T
R
Q
P
R
L
F
D
Y
L
F
T
---
H
R
N
K
H
K
L
M
A
L
I
D
V
PQ
M
K
P
L
V
H
V
S
G
M
F
G
A
W
R
G
N
T
S
W
V
A
P
L
A
W
H
P
E
--
N
R
N
A
V
I
M
V
----
D
L
A
G
D
I
S
P
L
L
E
L
D
S
D
T
L
R
E
----
R
L
Y
T
A
K
-------------
T
D
L
G
D
N
A
-
A
V
P
V
K
L
V
H
I
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
----------------------
E
D
A
D
R
L
G
I
N
R
Q
H
C
L
D
N
L
K
I
-------------
L
R
E
N
P
Q
V
-
R
E
K
V
V
A
I
F
A
E
---
F
T
P
S
D
N
V
D
A
Q
L
Y
N
G
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
-
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
-----------------------------------------------------------------------------------
3
PsiBlast_PDB
94.80
50%
-95
- C7 -
4JS4
10
EX1_ECOLI
A:
[12-430]
----
S
T
F
L
F
H
D
Y
E
T
F
---
G
T
H
P
--
A
-
L
---
D
R
P
A
Q
F
A
A
I
R
T
D
S
----------------
E
------------------
F
N
V
I
-
G
--
E
--------
P
E
V
F
Y
C
K
P
A
D
D
Y
--
L
P
---------
Q
P
G
A
V
L
I
T
---
G
I
-
T
P
Q
E
A
R
-
A
-
K
G
--
E
N
E
A
A
F
A
A
R
-
I
H
S
L
F
T
-----
V
-------
P
-----
K
T
C
I
L
G
Y
N
N
V
--------
R
F
---
D
D
E
-
V
-
T
R
N
I
F
Y
R
N
------
F
Y
D
P
Y
A
W
S
W
Q
H
D
N
S
R
W
D
L
L
D
V
M
R
A
C
Y
A
L
R
P
E
G
I
N
W
P
E
N
D
D
G
L
P
S
F
R
L
E
----
H
L
T
K
A
N
G
I
E
-
H
--
S
N
A
H
D
A
M
-
A
D
V
Y
A
T
I
A
M
A
K
L
V
K
T
R
Q
P
R
L
F
D
Y
L
F
T
---
H
R
N
K
H
K
L
M
A
L
I
D
V
PQ
M
K
P
L
V
H
V
S
G
M
F
G
A
W
R
G
N
T
S
W
V
A
P
L
A
W
H
P
E
--
N
R
N
A
V
I
M
V
----
D
L
A
G
D
I
S
P
L
L
E
L
D
S
D
T
L
R
E
----
R
L
Y
T
A
K
-------------
T
D
L
G
D
N
A
-
A
V
P
V
K
L
V
H
I
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
----------------------
E
D
A
D
R
L
G
I
N
R
Q
H
C
L
D
N
L
K
I
-------------
L
R
E
N
P
Q
V
-
R
E
K
V
V
A
I
F
A
E
A
E
P
F
T
P
S
D
N
V
D
A
Q
L
Y
N
G
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
-
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
-----------------------------------------------------------------------------------
18
PsiBlast_CBE
94.67
50%
-95
- C7 -
4JRP
12
EX1_ECOLI
B:
[12-430]
----
S
T
F
L
F
H
D
Y
E
T
F
---
G
T
H
P
--
A
-
L
---
D
R
P
A
Q
F
A
A
I
R
T
D
S
----------------
E
------------------
F
N
V
I
-
G
--
E
--------
P
E
V
F
Y
C
K
P
A
D
D
Y
--
L
P
---------
Q
P
G
A
V
L
I
T
---
G
I
-
T
P
Q
E
A
R
-
A
-
K
G
--
E
N
E
A
A
F
A
A
R
-
I
H
S
L
F
T
-----
V
-------
P
-----
K
T
C
I
L
G
Y
N
N
V
--------
R
F
---
D
D
E
-
V
-
T
R
N
I
F
Y
R
N
------
F
Y
D
P
Y
A
W
S
W
Q
H
D
N
S
R
W
D
L
L
D
V
M
R
A
C
Y
A
L
R
P
E
G
I
N
W
P
E
N
D
D
G
L
P
S
F
R
L
E
----
H
L
T
K
A
N
G
I
E
-
H
------
D
A
M
-
A
D
V
Y
A
T
I
A
M
A
K
L
V
K
T
R
Q
P
R
L
F
D
Y
L
F
T
---
H
R
N
K
H
K
L
M
A
L
I
D
V
PQ
M
K
P
L
V
H
V
S
G
M
F
G
A
W
R
G
N
T
S
W
V
A
P
L
A
W
H
P
E
--
N
R
N
A
V
I
M
V
----
D
L
A
G
D
I
S
P
L
L
E
L
D
S
D
T
L
R
E
----
R
L
Y
T
A
K
-------------
T
D
L
G
D
N
A
-
A
V
P
V
K
L
V
H
I
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
----------------------
E
D
A
D
R
L
G
I
N
R
Q
H
C
L
D
N
L
K
I
-------------
L
R
E
N
P
Q
V
-
R
E
K
V
V
A
I
F
A
E
A
E
P
F
T
P
S
D
N
V
D
A
Q
L
Y
N
G
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
-
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
-----------------------------------------------------------------------------------
2
PsiBlast_PDB
94.51
50%
-96
- C7 -
4HCB
7
EX1_ECOLI
A:
[9-427]
----
S
T
F
L
F
H
D
Y
E
T
F
---
G
T
H
P
--
A
-
L
---
D
R
P
A
Q
F
A
A
I
R
T
D
S
----------------
E
------------------
F
N
V
I
-
G
--
E
--------
P
E
V
F
Y
C
K
P
A
D
D
Y
--
L
P
---------
Q
P
G
A
V
L
I
T
---
G
I
-
T
P
Q
E
A
R
-
A
-
K
G
--
E
N
E
A
A
F
A
A
R
-
I
H
S
L
F
T
-----
V
-------
P
-----
K
T
C
I
L
G
Y
N
N
V
--------
R
F
---
D
D
E
-
V
-
T
R
N
I
F
Y
R
N
------
F
Y
D
P
Y
A
W
S
W
Q
H
D
N
S
R
W
D
L
L
D
V
M
R
A
C
Y
A
L
R
P
E
G
I
N
W
P
E
N
---
L
P
S
F
R
L
E
----
H
L
T
K
A
N
G
I
E
--------
D
A
M
-
A
D
V
Y
A
T
I
A
M
A
K
L
V
K
T
R
Q
P
R
L
F
D
Y
L
F
T
---
H
R
N
K
H
K
L
M
A
L
I
D
V
PQ
M
K
P
L
V
H
V
S
G
M
F
G
A
W
R
G
N
T
S
W
V
A
P
L
A
W
H
P
E
--
N
R
N
A
V
I
M
V
----
D
L
A
G
D
I
S
P
L
L
E
L
D
S
D
T
L
R
E
----
R
L
Y
T
A
K
-------------
T
D
L
G
D
N
A
-
A
V
P
V
K
L
V
H
I
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
----------------------
E
D
A
D
R
L
G
I
N
R
Q
H
C
L
D
N
L
K
I
-------------
L
R
E
N
P
Q
V
-
R
E
K
V
V
A
I
F
A
E
A
E
P
F
T
P
S
D
N
V
D
A
Q
L
Y
N
G
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
-
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
-----------------------------------------------------------------------------------
17
PsiBlast_CBE
94.35
50%
-95
- C7 -
4HCB
8
EX1_ECOLI
B:
[9-427]
----
S
T
F
L
F
H
D
Y
E
T
F
---
G
T
H
P
--
A
-
L
---
D
R
P
A
Q
F
A
A
I
R
T
D
S
----------------
E
------------------
F
N
V
I
-
G
--
E
--------
P
E
V
F
Y
C
K
P
A
D
D
Y
--
L
P
---------
Q
P
G
A
V
L
I
T
---
G
I
-
T
P
Q
E
A
R
-
A
-
K
G
--
E
N
E
A
A
F
A
A
R
-
I
H
S
L
F
T
-----
V
-------
P
-----
K
T
C
I
L
G
Y
N
N
V
--------
R
F
---
D
D
E
-
V
-
T
R
N
I
F
Y
R
N
------
F
Y
D
P
Y
A
W
S
W
Q
H
D
N
S
R
W
D
L
L
D
V
M
R
A
C
Y
A
L
R
P
E
G
I
N
W
P
E
N
---
L
P
S
F
R
L
E
----
H
L
T
K
A
N
G
I
E
--------
D
A
M
-
A
D
V
Y
A
T
I
A
M
A
K
L
V
K
T
R
Q
P
R
L
F
D
Y
L
F
T
---
H
R
N
K
H
K
L
M
A
L
I
D
V
PQ
M
K
P
L
V
H
V
S
G
M
F
G
A
W
R
G
N
T
S
W
V
A
P
L
A
W
H
P
E
--
N
R
N
A
V
I
M
V
----
D
L
A
G
D
I
S
P
L
L
E
L
D
S
D
T
L
R
E
----
R
L
Y
T
A
K
-------------
T
D
L
G
D
N
A
-
A
V
P
V
K
L
V
H
I
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
----------------------
E
D
A
D
R
L
G
I
N
R
Q
H
C
L
D
N
L
K
I
-------------
L
R
E
N
P
Q
V
-
R
E
K
V
V
A
I
F
A
E
A
E
P
F
T
P
S
D
N
V
D
A
Q
L
Y
N
G
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
-
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
-----------------------------------------------------------------------------------
4
PsiBlast_PDB
93.60
50%
-97
- C7 -
3C94
4
EX1_ECOLI
A:
[9-427]
----
S
T
F
L
F
H
D
Y
E
T
F
---
G
T
H
P
--
A
-
L
---
D
R
P
A
Q
F
A
A
I
R
T
D
S
----------------
E
------------------
F
N
V
I
-
G
--
E
--------
P
E
V
F
Y
C
K
P
A
D
D
Y
--
L
P
---------
Q
P
G
A
V
L
I
T
---
G
I
-
T
P
Q
E
A
R
-
A
-
K
G
--
E
N
E
A
A
F
A
A
R
-
I
H
S
L
F
T
-----
V
-------
P
-----
K
T
C
I
L
G
Y
N
N
V
--------
R
F
---
D
D
E
-
V
-
T
R
N
I
F
Y
R
N
------
F
Y
D
P
Y
A
W
S
W
Q
H
D
N
S
R
W
D
L
L
D
V
M
R
A
C
Y
A
L
R
P
E
G
I
N
W
P
E
N
D
D
G
L
P
S
F
R
L
E
----
H
L
T
K
A
N
G
I
E
-
H
--
S
---
D
A
M
-
A
D
V
Y
A
T
I
A
M
A
K
L
V
K
T
R
Q
P
R
L
F
D
Y
L
F
T
---
H
R
N
K
H
K
L
M
A
L
I
D
V
PQ
M
K
P
L
V
H
V
S
G
M
F
G
A
W
R
G
N
T
S
W
V
A
P
L
A
W
H
P
E
--
N
R
N
A
V
I
M
V
----
D
L
A
G
D
I
S
P
L
L
E
L
D
S
D
T
L
R
E
----
R
L
Y
T
A
K
-------------
T
D
L
--
N
A
-
A
V
P
V
K
L
V
H
I
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
----------------------
E
D
A
D
R
L
G
I
N
R
Q
H
C
L
D
N
L
K
I
-------------
L
R
E
N
P
Q
V
-
R
E
K
V
V
A
I
F
A
-------
S
D
N
V
D
A
Q
L
Y
N
G
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
-
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
-----------------------------------------------------------------------------------
1
PsiBlast_PDB
93.45
50%
-94
- C7 -
4HCC
9
EX1_ECOLI
A:
[9-427]
----
S
T
F
L
F
H
D
Y
E
T
F
---
G
T
H
P
--
A
-
L
---
D
R
P
A
Q
F
A
A
I
R
T
D
S
----------------
E
------------------
F
N
V
I
-
G
--
E
--------
P
E
V
F
Y
C
K
P
A
D
D
Y
--
L
P
---------
Q
P
G
A
V
L
I
T
---
G
I
-
T
P
Q
E
A
R
-
A
-
K
G
--
E
N
E
A
A
F
A
A
R
-
I
H
S
L
F
T
-----
V
-------
P
-----
K
T
C
I
L
G
Y
N
N
V
--------
R
F
---
D
D
E
-
V
-
T
R
N
I
F
Y
R
N
------
F
Y
D
P
Y
A
W
S
W
Q
H
D
N
S
R
W
D
L
L
D
V
M
R
A
C
Y
A
L
R
P
E
G
I
N
W
P
E
N
---
L
P
S
F
R
L
E
----
H
L
T
K
A
N
G
I
E
-
H
--
S
N
A
H
D
A
M
-
A
D
V
Y
A
T
I
A
M
A
K
L
V
K
T
R
Q
P
R
L
F
D
Y
L
F
T
---
H
R
N
K
H
K
L
M
A
L
I
D
V
PQ
M
K
P
L
V
H
V
S
G
M
F
G
A
W
R
G
N
T
S
W
V
A
P
L
A
W
H
P
E
--
N
R
N
A
V
I
M
V
----
D
L
A
G
D
I
S
P
L
L
E
L
D
S
D
T
L
R
E
----
R
L
Y
T
A
K
-------------
T
D
L
G
D
N
A
-
A
V
P
V
K
L
V
H
I
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
----------------------
E
D
A
D
R
L
G
I
N
R
Q
H
C
L
D
N
L
K
I
-------------
L
R
E
N
P
Q
V
-
R
E
K
V
V
A
I
F
--A
E
P
F
T
P
S
D
N
V
D
A
Q
L
Y
N
G
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
-
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
-----------------------------------------------------------------------------------
6
PsiBlast_PDB
92.49
50%
-98
- C7 -
3HP9
8
EX1_ECOLI
A:
[9-427]
----
S
T
F
L
F
H
D
Y
E
T
F
---
G
T
H
P
--
A
-
L
---
D
R
P
A
Q
F
A
A
I
R
T
D
S
----------------
E
------------------
F
N
V
I
-
G
--
E
--------
P
E
V
F
Y
C
K
P
A
D
D
Y
--
L
P
---------
Q
P
G
A
V
L
I
T
---
G
I
-
T
P
Q
E
A
R
-
A
-
K
G
--
E
N
E
A
A
F
A
A
R
-
I
H
S
L
F
T
-----
V
-------
P
-----
K
T
C
I
L
G
Y
N
N
V
--------
R
F
---
D
D
E
-
V
-
T
R
N
I
F
Y
R
N
------
F
Y
D
P
Y
A
W
S
W
Q
H
D
N
S
R
W
D
L
L
D
V
M
R
A
C
Y
A
L
R
P
E
G
I
N
W
P
E
N
D
D
G
L
P
S
F
R
L
E
----
H
L
T
K
A
N
G
I
E
-
H
--
S
---
D
A
M
-
A
D
V
Y
A
T
I
A
M
A
K
L
V
K
T
R
Q
P
R
L
F
D
Y
L
F
T
---
H
R
N
K
H
K
L
M
A
L
I
D
V
PQ
M
K
P
L
V
H
V
S
G
M
F
G
A
W
R
G
N
T
S
W
V
A
P
L
A
W
H
P
E
--
N
R
N
A
V
I
M
V
----
D
L
A
G
D
I
S
P
L
L
E
L
D
S
D
T
L
R
E
----
R
L
Y
---------------------
N
A
-
A
V
P
V
K
L
V
H
I
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
----------------------
E
D
A
D
R
L
G
I
N
R
Q
H
C
L
D
N
L
K
I
-------------
L
R
E
N
P
Q
V
-
R
E
K
V
V
A
I
F
A
E
------
S
D
N
V
D
A
Q
L
Y
N
G
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
-
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
-----------------------------------------------------------------------------------
5
PsiBlast_PDB
91.29
50%
-97
- C7 -
3C95
1
EX1_ECOLI
A:
[9-427]
----
S
T
F
L
F
H
D
Y
E
T
F
---
G
T
H
P
--
A
-
L
---
D
R
P
A
Q
F
A
A
I
R
T
D
S
----------------
E
------------------
F
N
V
I
-
G
--
E
--------
P
E
V
F
Y
C
K
P
A
D
D
Y
--
L
P
---------
Q
P
G
A
V
L
I
T
---
G
I
-
T
P
Q
E
A
R
-
A
-
K
G
--
E
N
E
A
A
F
A
A
R
-
I
H
S
L
F
T
-----
V
-------
P
-----
K
T
C
I
L
G
Y
N
N
V
--------
R
F
---
D
D
E
-
V
-
T
R
N
I
F
Y
R
N
------
F
Y
D
P
Y
A
W
S
W
Q
H
D
N
S
R
W
D
L
L
D
V
M
R
A
C
Y
A
L
R
P
E
G
I
N
W
P
E
N
D
D
G
L
P
S
F
R
L
E
----
H
L
T
K
A
N
G
I
E
-
H
------
D
A
M
-
A
D
V
Y
A
T
I
A
M
A
K
L
V
K
T
R
Q
P
R
L
F
D
Y
L
F
T
---
H
R
N
K
H
K
L
M
A
L
I
D
V
PQ
M
K
P
L
V
H
V
S
G
M
F
G
A
W
R
G
N
T
S
W
V
A
P
L
A
W
H
P
E
--
N
R
N
A
V
I
M
V
----
D
L
A
G
D
I
S
P
L
L
E
L
D
S
D
T
L
R
--------------------------------
A
V
P
V
K
L
V
H
I
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
----------------------
E
D
A
D
R
L
G
I
N
R
Q
H
C
L
D
N
L
K
I
-------------
L
R
E
N
P
Q
V
-
R
E
K
V
V
A
I
F
A
E
------
S
D
N
V
D
A
Q
L
Y
N
G
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
-
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
-----------------------------------------------------------------------------------
42
Fugue
63.48
57%
-75
- C7 -
1FXX
2
EX1_ECOLI
A:
[8-208]
---
Q
S
T
F
L
F
H
D
Y
E
T
F
---
G
T
--HP
A
-
L
---
D
R
P
A
Q
F
A
A
I
R
T
D
S
----------------
E
------------------
F
N
V
I
-
G
--
E
--------
P
E
V
F
Y
C
K
P
A
D
D
Y
--
L
P
---------
Q
P
G
A
V
L
I
T
---
G
I
-
T
P
Q
E
A
R
-
A
-
K
G
--
E
N
E
A
A
F
A
A
R
-
I
H
S
L
F
T
-----
V
-------
P
-----
K
T
C
I
L
G
Y
N
N
V
--------
R
F
---
D
D
E
-
V
-
T
R
N
I
F
Y
R
N
------
F
Y
D
P
Y
A
W
S
W
Q
H
D
N
S
R
W
D
L
L
D
V
M
R
A
C
Y
A
L
R
P
E
G
I
N
W
P
---
E
G
L
P
S
F
R
L
E
----
H
L
T
K
A
N
G
I
E
-
H
--
S
N
A
H
D
A
M
-
A
D
V
Y
A
T
I
A
M
A
K
L
V
K
T
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
46.58
19%
-52
- C4 -
4XGC
-
?
C:
[1-676]
M
Q
-----
P
F
Y
E
E
Y
R
K
---
A
W
N
Q
--
I
-
N
---
D
H
I
A
D
L
Q
H
R
S
Y
A
R
----------------
T
------------------
L
E
Q
L
-
V
--
D
--------
F
V
V
G
Q
A
E
R
D
E
V
L
--------------
P
T
A
A
L
L
T
---
G
I
N
Q
P
D
H
L
S
-
Q
-
F
T
--
A
L
T
Q
R
L
H
A
Q
-
R
A
A
M
V
C
V
L
Q
SR
D
-------
C
-----
A
T
L
K
A
A
V
E
T
L
--------
V
F
G
L
V
E
D
N
-
A
-
E
V
E
Q
L
R
R
S
QCT
M
K
Q
L
K
S
W
Y
T
N
N
F
D
S
E
Q
K
R
R
Q
L
V
V
I
L
P
D
F
E
C
F
N
A
S
V
L
Q
--
D
L
-
I
L
I
L
S
A
H
C
G
SLP
F
V
L
V
L
G
V
A
T
A
-
M
--
T
A
V
H
G
T
L
P
Y
H
V
S
S
K
I
R
L
R
V
F
Q
T
Q
A
A
P
T
G
L
N
E
V
L
D
K
VL
L
S
P
K
Y
A
F
H
L
S
G
K
T
--
F
K
F
L
T
H
I
F
L
Y
Y
D
F
S
I
H
G
F
I
Q
G
F
K
Y
C
L
M
E
H
F
F
G
G
N
A
F
A
L
C
TD
Y
S
K
A
L
G
R
I
K
Q
L
T
H
E
D
M
E
T
I
R
R
LPS
F
R
P
Y
V
E
Q
IND
C
K
R
I
I
A
V
L
TD
D
D
Y
L
K
K
K
L
P
Q
L
L
R
D
C
L
L
H
F
L
L
F
R
C
S
L
E
F
L
T
E
L
V
G
D
LPRCPLGKL
R
R
E
L
Y
V
N
C
L
N
R
A
I
I
S
T
P
E
Y
K
E
C
L
Q
M
L
S
F
LSK
D
E
F
V
A
K
V
N
R
A
L
E
R
T
E
Q
F
L
V
E
E
I
A
P
L
E
L
G
-
E
A
C
T
A
V
L
R
P
K
L
E
A
I
R
L
A
V
D
E
V
G
R
A
L
Q
K
T
L
Q
L
I
E
T
Q
I
V
Q
D
H
L
R
A
L
Q
D
A
P
P
I
H
E
L
F
V
F
S
D
I
A
T
V
R
R
N
I
I
G
A
P
R
A
A
L
H
T
A
L
N
N
P
HFP
D
L
S
V
V
Y
K
L
H
L
E
C
G
R
M
I
N
L
F
D
W
L
Q
A
F
R
S
V
V
---------
P
Q
I
Q
A
R
F
T
R
A
V
A
E
L
Q
F
L
G
Y
I
K
M
SKRKTD
H
A
T
R
LTW
33
HHSearch
43.18
25%
-42
- C7 -
2GBZ
1
ORN_XANCP
A:
[8-183]
---
N
D
R
L
I
W
I
D
L
E
M
T
---
G
L
D
T
--
D
-
R
---
D
S
I
I
E
I
A
T
I
V
T
D
A
----------------
Q
------------------
L
N
V
L
-
A
--
E
G
P
E
L
A
I
A
H
S
L
E
T
L
E
A
M
D
E
W
N
R
-
N
Q
---------
H
R
R
S
G
L
W
Q
---
R
V
-
L
D
S
Q
V
--
T
-
H
A
--
Q
A
E
A
Q
T
V
A
F
-
L
G
E
W
I
R
-----
A
-------
G
-----
A
S
P
M
C
G
N
S
I
---------
C
Q
---
D
R
R
-
F
-
L
H
R
Q
M
S
R
L
------
E
R
Y
-----
F
--
H
Y
R
N
L
D
V
S
T
I
K
E
L
A
R
R
W
A
P
------------------------
A
V
A
S
G
F
A
-
K
--
S
S
A
H
T
A
L
-
S
D
V
R
D
S
I
D
E
L
R
H
Y
R
Q
F
M
G
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
42.71
22%
-42
- C7 -
2IGI
15
ORN_ECOLI
A:
[3-178]
--
N
E
N
N
L
I
W
I
D
L
E
M
T
---
G
L
D
P
--
E
-
R
---
D
R
I
I
E
I
A
T
L
V
T
D
A
----------------
N
------------------
L
N
I
L
-
A
--
E
--------
G
P
T
I
A
V
H
Q
S
D
E
Q
L
A
L
M
---------
D
D
W
N
V
R
T
H
T
A
S
G
L
-
V
E
R
V
K
--
A
-
S
T
--
M
G
D
R
E
A
E
L
A
-
T
L
E
F
L
K
-----
Q
WVPA---
G
-----
K
S
P
I
C
G
N
S
I
---------
G
Q
---
D
R
R
-
F
-
L
F
K
Y
M
P
E
L
------
E
A
Y
-
F
------
H
Y
R
Y
L
D
V
S
T
L
K
E
L
A
R
R
W
K
P
----------
E
I
----
L
----------
D
G
F
T
-
K
--
Q
G
T
H
Q
A
M
-
D
D
I
R
E
S
V
A
E
L
A
Y
Y
R
E
H
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
42.52
19%
-43
- C7 -
3U3Y
2
TREX1_MOUSE
B:
[10-215]
--
H
M
Q
T
L
I
F
L
D
L
E
A
T
---
G
L
P
S
--
S
-
R
---
P
E
V
T
E
L
C
L
L
A
V
H
R
R
A
L
E
NISQGHPPPVPR
P
------------------
P
R
V
V
----
D
--------
K
L
S
L
C
I
A
P
G
K
----
A
C
---------
S
P
G
A
S
E
I
T
---
G
L
-
S
K
A
E
L
E
-
V
Q
G
R
--
Q
R
F
D
D
N
L
A
I
L
L
R
A
F
L
Q
-----
R
QP-----
Q
-----
P
C
C
L
V
A
H
N
G
D
--------
R
Y
---
D
F
P
-
L
-
L
Q
T
E
L
A
R
L
------
S
T
P
S
P
---
L
-
D
G
T
F
C
V
D
S
I
---
A
A
L
K
A
L
E
Q
A
S
---------
R
K
S
Y
S
L
G
----
S
I
Y
T
R
L
Y
W
Q
A
P
--
T
D
S
H
T
A
E
-
G
H
V
L
T
L
L
S
I
C
Q
W
K
P
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
41.70
19%
-47
- C7 -
3V9W
5
RNT_ECOLI
A:
[36-222]
---
G
F
Y
P
V
V
I
D
V
E
T
A
---
G
F
N
A
--
K
-
T
---
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E--------------
Q
------------------
G
W
L
M
P
D
--
T
--------
T
L
H
F
H
V
E
P
F
V
G
A
--
N
L
---------
Q
P
E
A
L
A
F
N
---
G
I
-
D
P
N
D
P
D
-
R
-
G
A
--
V
S
G
Y
E
A
L
H
E
-
I
F
K
V
V
R
-----
K
G
I
K
A
S
GC
N
-----
R
A
I
M
V
A
H
N
A
---------
N
F
---
D
H
S
-
F
-
M
M
A
A
A
E
R
A
------
S
L
K
R
N
P
--
F
-
H
P
F
A
T
---
F
D
T
A
A
L
A
G
L
A
L
G
-------------
Q
T
V
L
S
----
K
A
C
Q
T
A
G
M
D
-
F
D
S
T
Q
A
H
S
A
L
-
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
41.69
14%
-55
- C7 -
3CG7
-
CRN4_CAEEL
A:
[18-209]
---
F
D
T
L
L
I
L
D
F
E
T
T
---
S
D
A
A
--
N
-
Q
DYP
C
E
V
I
Q
F
A
I
V
A
Y
D
V
----------------
P
------------------
N
D
K
I
-
R
ED
I
--------
S
F
N
K
Y
V
K
P
V
L
N
R
--
T
L
---------
T
K
N
C
V
D
F
T
---
G
I
-
P
Q
R
S
I
--
D
-
T
A
--
D
T
F
D
V
V
Y
E
Q
-
F
Q
Q
W
L
I
-----
T
L
GLEE--
G
-----
K
F
A
F
V
C
D
S
----------
R
Q
---
D
L
W
-
R
I
A
Q
Y
Q
M
K
L
S
------
N
I
Q
M
P
-------
A
F
F
R
Q
Y
I
N
L
Y
K
I
F
T
N
E
M
D
R
M
-
G
P
K
---
E
L
S
A
T
T
N
I
G
----
K
M
N
E
Y
Y
D
L
P
-
T
I-
G
R
A
H
D
A
M
-
D
D
C
L
N
I
A
T
I
L
Q
R
M
I
N
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
41.52
24%
-43
- C7 -
5CY4
4
?
A:
[12-185]
-
T
L
N
T
R
L
I
W
I
D
L
E
M
T
---
G
L
D
T
--
D
-
N
---
D
Q
I
I
E
I
A
T
I
I
T
D
D
----------------
H
------------------
L
N
V
L
-
A
--
E
--------
G
P
V
L
A
I
H
Q
P
D
R
I
--
L
N
A
MD
E
W
N
T
R
Q
H
G
Q
S
G
L
I
E
---
R
V
-
R
R
S
K
L
T
-
A
-
R
D
A
E
L
Q
T
L
E
F
L
K
K
-----
W
V
-----
N
-------
P
-----
K
V
S
P
M
C
G
N
S
I
C
Q
D
R
R
F
L
H
R
L
---
M
P
E
-
L
-
E
Q
Y
F
H
Y
R
N
------
L
D
V
S
T
V
K
E
L
---
S
K
R
W
------------
R
P
E
------------------------
I
M
S
G
L
K
-----
A
S
H
L
A
M
-
D
D
I
R
D
S
I
S
E
L
K
Y
Y
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
41.17
19%
-39
- C7 -
3MXM
7
TREX1_MOUSE
B:
[9-215]
-
G
H
M
Q
T
L
I
F
L
D
L
E
A
T
---
G
L
P
S
--
S
-
R
---
P
E
V
T
E
L
C
L
L
A
V
H
R
----------------
R
A
L
E
N
TSISQGHPPPVPRP
P
R
V
V
----
D
--------
K
L
S
L
C
I
A
P
G
K
----
A
C
---------
S
P
G
A
S
E
I
T
---
G
L
-
S
K
A
E
L
E
V
Q
-
G
R
--
Q
R
F
D
D
N
L
A
I
L
L
R
A
F
L
Q
-----
R
QP-----
Q
-----
P
C
C
L
V
A
H
N
G
D
--------
R
Y
---
D
F
P
-
L
-
L
Q
T
E
L
A
R
L
------
S
T
P
S
P
---
L
-
D
G
T
F
C
V
D
S
I
---
A
A
L
K
A
L
E
Q
A
--
S
S
P
------
K
S
Y
S
L
G
----
S
I
Y
T
R
L
Y
W
Q
A
P
--
T
D
S
H
T
A
E
-
G
D
D
L
T
L
L
S
I
C
Q
W
K
P
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
41.12
16%
-45
- C7 -
1W0H
3
ERI1_HUMAN
A:
[7-197]
-
S
Y
Y
D
Y
I
C
I
I
D
F
E
A
T
C
E
E
G
N
P
P
--
E
F
V
---
H
E
I
I
E
F
P
V
V
L
L
N
T
H---------------
T
------------------
L
E
I
E
----
D
--------
T
F
Q
Q
Y
V
R
P
E
I
N
T
--
Q
L
---------
S
D
F
C
I
S
L
T
---
G
I
-
T
Q
D
Q
V
--
D
-
R
A
--
D
T
F
P
Q
V
L
K
K
-
V
I
D
W
M
K
-----
L
-------
K
ELGTK
Y
K
Y
S
L
L
T
D
G
---------
S
W
---
D
M
S
K
F
-
L
N
I
Q
C
Q
L
S
------
R
L
K
Y
P
P
----
F
A
K
K
W
---
I
N
I
R
K
S
Y
G
N
F
Y
K
V
---------
P
R
S
Q
T
K
L
T
----
I
M
L
E
K
L
G
M
D
-
Y
D-
G
R
P
H
C
G
L
-
D
D
S
K
N
I
A
R
I
A
V
R
M
L
Q
D
G
C
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------