@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4406: (2016-02-27 )
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRPAAAV
Atome Classification :
(68 SA)
.........10........20........30........40........50........60......-..70........80........90........100.......110.......120.......130.......140.......150.......160....--...170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MI
K
Q
R
T
L
K
N
I
I
R
A
TGVGLHSG
E
K
V
Y
L
T
LKPAPVD
T
G
I
V
F
CRTDL
D
P
V
VEIPARAENVGETT
M
S
T
T
L
V
-KGDV
K
V
D
T
V
E
H
L
L
S
A
M
A
GLGID
N
A
Y
V
E
L
SASEVPIMDGSAG
P
F
V
F
L
I
QSAGL
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
VSVEEGDK
R
A
V
F
V
PFDG
F
K
V
S
F
E
I
DFDHPVFR--GRTQQ
A
S
VDFS
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
RSQNLALGGSV
E
N
A
I
V
VDENRVLNEDGLR
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
RGFKSGH
A
L
N
N
Q
L
L
R
T
L
IADKDA
W
E
V
V
T
FEDARTAP
I
S
YMRPAAAV
29
PsiBlast_CBE
99.55
99%
-108
- C8 -
4FW5
6
LPXC_PSEAE
B:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
34
PsiBlast_CBE
99.15
99%
-106
- C8 -
4FW3
2
LPXC_PSEAE
C:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
2
PsiBlast_PDB
98.91
99%
-105
- C8 -
4FW4
2
LPXC_PSEAE
A:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
38
PsiBlast_CBE
98.83
99%
-103
- C8 -
2VES
6
LPXC_PSEAE
C:
[1-299]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
3
PsiBlast_PDB
98.66
99%
-109
- C8 -
4FW5
5
LPXC_PSEAE
A:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
22
PsiBlast_CBE
98.54
99%
-105
- C8 -
4FW7
3
LPXC_PSEAE
C:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
32
PsiBlast_CBE
98.53
99%
-107
- C8 -
4FW4
4
LPXC_PSEAE
B:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
31
PsiBlast_CBE
98.50
99%
-102
- C8 -
4FW4
4
LPXC_PSEAE
C:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
9
PsiBlast_PDB
98.46
99%
-105
- C8 -
4LCF
15
LPXC_PSEAE
A:
[1-298]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
-----
21
PsiBlast_CBE
98.34
99%
-103
- C8 -
4FW7
6
LPXC_PSEAE
D:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
33
PsiBlast_CBE
98.33
99%
-106
- C8 -
4FW3
3
LPXC_PSEAE
D:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
30
PsiBlast_CBE
98.31
99%
-103
- C8 -
4FW4
3
LPXC_PSEAE
D:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
11
PsiBlast_PDB
98.16
99%
-104
- C8 -
4LCH
20
LPXC_PSEAE
A:
[1-296]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
-------
23
PsiBlast_CBE
98.07
99%
-103
- C8 -
4FW7
11
LPXC_PSEAE
B:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
7
PsiBlast_PDB
98.06
99%
-105
- C8 -
3U1Y
2
LPXC_PSEAE
A:
[1-299]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
37
PsiBlast_CBE
97.95
99%
-102
- C8 -
3U1Y
4
LPXC_PSEAE
B:
[1-299]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
4
PsiBlast_PDB
97.90
99%
-106
- C8 -
4FW6
9
LPXC_PSEAE
A:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
35
PsiBlast_CBE
97.86
99%
-107
- C8 -
4FW3
2
LPXC_PSEAE
B:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
5
PsiBlast_PDB
97.83
99%
-105
- C8 -
4FW7
8
LPXC_PSEAE
A:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
26
PsiBlast_CBE
97.72
99%
-106
- C8 -
4FW6
9
LPXC_PSEAE
B:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
12
PsiBlast_PDB
97.68
99%
-106
- C8 -
4OKG
2
LPXC_PSEAE
A:
[1-299]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
25
PsiBlast_CBE
97.60
99%
-102
- C8 -
4FW6
4
LPXC_PSEAE
C:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
39
PsiBlast_CBE
97.51
99%
-101
- C8 -
2VES
5
LPXC_PSEAE
B:
[1-288]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
---------------
8
PsiBlast_PDB
97.51
99%
-103
- C8 -
3UHM
4
LPXC_PSEAE
A:
[1-299]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
10
PsiBlast_PDB
97.49
99%
-105
- C8 -
4LCG
19
LPXC_PSEAE
A:
[1-296]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
-------
28
PsiBlast_CBE
97.45
99%
-102
- C8 -
4FW5
4
LPXC_PSEAE
C:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
1
PsiBlast_PDB
97.42
99%
-104
- C8 -
4FW3
3
LPXC_PSEAE
A:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
6
PsiBlast_PDB
97.39
99%
-99
- C8 -
2VES
5
LPXC_PSEAE
A:
[1-294]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
---------
27
PsiBlast_CBE
97.20
99%
-101
- C8 -
4FW5
3
LPXC_PSEAE
D:
[4-302]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
--
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
77
HHSearch
97.18
99%
-104
- C8 -
3UHM
4
LPXC_PSEAE
A:
[1-299]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
R
G
R
T
Q
--
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
36
PsiBlast_CBE
96.89
99%
-103
- C8 -
4OKG
2
LPXC_PSEAE
B:
[1-299]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
----------
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
----
13
PsiBlast_PDB
95.62
100%
-105
- C8 -
4J3D
3
LPXC_PSEAE
A:
[1-297]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
C
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
------------
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
------
40
PsiBlast_CBE
93.73
100%
-98
- C8 -
4J3D
3
LPXC_PSEAE
B:
[1-296]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
C
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
-
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
------------
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
-------
41
PsiBlast_CBE
88.88
58%
-95
- C8 -
3NZK
2
?
B:
[6-305]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
M
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
I
I
E
V
N
A
P
E
V
P
I
M
D
G
S
A
S
P
F
V
Y
L
L
L
D
A
G
I
E
E
L
N
S
A
K
K
F
L
R
L
K
E
T
V
R
V
E
D
G
D
K
W
A
E
L
S
P
F
N
G
F
R
L
D
F
T
I
D
F
N
H
P
A
I
D
--
S
S
T
Q
R
Y
R
L
D
F
S
A
D
S
F
V
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
F
V
T
F
Q
D
E
A
E
M
P
L
A
F
K
A
P
----
18
PsiBlast_PDB
88.36
58%
-96
- C8 -
4ISA
21
?
A:
[1-300]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
D
--
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
P
----
14
PsiBlast_PDB
87.76
58%
-101
- C8 -
3NZK
3
?
A:
[6-303]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
M
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
I
I
E
V
N
A
P
E
V
P
I
M
D
G
S
A
S
P
F
V
Y
L
L
L
D
A
G
I
E
E
L
N
S
A
K
K
F
L
R
L
K
E
T
V
R
V
E
D
G
D
K
W
A
E
L
S
P
F
N
G
F
R
L
D
F
T
I
D
F
N
H
P
A
I
D
--
S
S
T
Q
R
Y
R
L
D
F
S
A
D
S
F
V
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
F
V
T
F
Q
D
E
A
E
M
P
L
A
F
K
------
15
PsiBlast_PDB
86.98
57%
-96
- C8 -
4MQY
9
?
A:
[1-302]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
D
--
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
P
S
A
--
17
PsiBlast_PDB
86.89
58%
-93
- C8 -
4IS9
3
?
A:
[1-300]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
D
--
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
P
----
16
PsiBlast_PDB
86.83
57%
-92
- C8 -
4MDT
3
?
A:
[1-300]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
S
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
D
--
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
P
----
45
PsiBlast_CBE
86.72
58%
-100
- C8 -
4IS9
3
?
B:
[1-299]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
D
--
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
-----
44
PsiBlast_CBE
86.67
57%
-92
- C8 -
4MDT
3
?
B:
[1-300]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
S
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
D
--
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
P
----
43
PsiBlast_CBE
86.59
57%
-93
- C8 -
4MDT
3
?
C:
[1-300]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
S
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
D
--
S
-
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
P
----
42
PsiBlast_CBE
86.30
57%
-92
- C8 -
4MDT
3
?
D:
[4-296]
---
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
S
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
D
--
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
--------
67
Fugue
73.48
36%
-73
- C8 -
4OZE
7
LPXC_AQUAE
A:
[2-267]
-
G
L
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
-
N
I
L
N
Q
N
R
E
I
D
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
F
L
----
G
R
Q
K
F
T
F
V
E
----
G
N
E
E
E
I
V
L
A
R
T
F
C
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
-------------------------
68
Fugue
73.20
35%
-78
- C8 -
1P42
5
LPXC_AQUAE
A:
[1-267]
-
G
L
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
-
I
D
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
F
L
-----
G
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
------------------------
56
PsiBlast_CBE
72.69
36%
-71
- C8 -
2J65
9
LPXC_AQUAE
A:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
66
PsiBlast_CBE
72.54
36%
-72
* C8 *
4OZE
7
LPXC_AQUAE
A:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
C
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
63
PsiBlast_CBE
72.32
36%
-70
- C8 -
2GO3
12
LPXC_AQUAE
B:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
47
PsiBlast_CBE
72.28
36%
-68
- C8 -
1YHC
10
LPXC_AQUAE
A:
[3-262]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
65
PsiBlast_CBE
72.12
36%
-75
- C8 -
4OZE
6
LPXC_AQUAE
B:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
C
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
49
PsiBlast_CBE
72.00
36%
-69
- C8 -
1P42
4
LPXC_AQUAE
B:
[3-262]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
62
PsiBlast_CBE
71.99
36%
-68
- C8 -
2GO4
6
LPXC_AQUAE
A:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
61
PsiBlast_CBE
71.79
36%
-68
- C8 -
2GO4
3
LPXC_AQUAE
B:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
55
PsiBlast_CBE
71.70
36%
-72
- C8 -
2J65
7
LPXC_AQUAE
B:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
51
PsiBlast_CBE
71.65
36%
-71
- C8 -
4U3B
6
LPXC_AQUAE
A:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
52
PsiBlast_CBE
71.64
36%
-69
- C8 -
3P76
4
LPXC_AQUAE
A:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
20
PsiBlast_PDB
71.62
36%
-69
- C8 -
1YH8
6
LPXC_AQUAE
A:
[3-262]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
50
PsiBlast_CBE
71.59
36%
-71
- C8 -
4U3D
5
LPXC_AQUAE
A:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
46
PsiBlast_CBE
71.49
36%
-70
- C8 -
1YHC
6
LPXC_AQUAE
B:
[3-262]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
59
PsiBlast_CBE
71.43
36%
-69
- C8 -
2IER
7
LPXC_AQUAE
B:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
48
PsiBlast_CBE
71.43
36%
-69
- C8 -
1YH8
5
LPXC_AQUAE
B:
[3-262]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
54
PsiBlast_CBE
71.29
36%
-72
- C8 -
2O3Z
6
LPXC_AQUAE
A:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
19
PsiBlast_PDB
71.23
36%
-69
- C8 -
1P42
5
LPXC_AQUAE
A:
[3-262]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
60
PsiBlast_CBE
70.78
36%
-69
- C8 -
2IER
8
LPXC_AQUAE
A:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
64
PsiBlast_CBE
70.77
36%
-71
- C8 -
2GO3
8
LPXC_AQUAE
A:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
53
PsiBlast_CBE
70.77
36%
-71
- C8 -
2O3Z
6
LPXC_AQUAE
B:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
58
PsiBlast_CBE
70.54
36%
-70
- C8 -
2IES
2
LPXC_AQUAE
A:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------
57
PsiBlast_CBE
70.52
36%
-70
- C8 -
2IES
2
LPXC_AQUAE
B:
[4-263]
---
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
G
----
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
G
-
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
Y
F
V
-
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
--
F
L
--
G
R
Q
K
F
T
F
V
E
G
N
E
----
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
-----------------------------