@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4408: (2016-02-27 )
MASVQSGKMIVGLDIGTSKVVALVGEVTADGQLEVVGIGTHPSRGLKKGVVVNIESTVQSIQRAIDEAQQMAGCRIHSAFVGIAGNHIRSLNSHGIVAIRDREVNPADIERVLDAAQAVAIPADQRVLHTLAQDYVIDNQEGVREPLGMSGVRLEAKVHVVTCAVNASQNIEKCVRRCGLEVDDIILEQLASAYSVLTEDEKELGVCLVDIGGGTTDIAIFTEGAIRHTAVIPIAGDQVTNDIAMALRTPTQYAEEIKIRYACALAKLAGAGETIKVPSVGDRPPRELSRQALAEVVEPRYDELFTLVQAELRRSGYEDLIPAGIVLTGGTSKMEGAVELAEEIFHMPVRLGVPYSVKGLTDVVRNPIYSTGVGLLMYGLQKQSDGMSMSVSGSSYSSDEPKAPVLERLKRWVQGNF
Atome Classification :
(20 SA)
.........10........20...-.....30.....----...40..------------.-.....-50-..-.....---.60........70.......-.80.-----..--------.--....90..--......--100-.........110-..-----.--.-....120.----.--.....130.......140.......150-.......-160...------....--170.......180-........190--.--.---.--...--.-------200-----.........210.......220--.....---.-----.230...--------....240.-------------------......-------------------250-----------------........----------------.260-.-------........270---..---....------------.280----.....----------....290.......300.-------......310......-.320.--......330.......340....-...350...-----.---...360------.......--------..370.......380.......390.......400...-------------....410.....---------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASVQSG
K
M
I
V
G
L
DIGT
S
K
V
V
A
L
V
-
G
EVTADG
Q
L
E
V
V
----
G
IGTHPS------------R-GLKK
G
-
V
V
-
V
N
-
I
E
S
T
V
---
Q
S
I
Q
R
A
I
D
E
A
Q
Q
M
AG
C
R
I
H
S
-
A
F
VG-----IA--------G--
N
H
I
RSLNS--H
G
I
V
A
I
--R---DREV
N
P
A
D
I
E
-
R
-
V
L
-----
D
--
A
-
A
Q
A
VAIP
A
----
D
--
Q
R
V
L
H
T
L
A
Q
D
YVIDN
Q
E
GVREPLGMS
G
V
-
R
L
E
A
K
V
H
-
V
V
T
C
AV------N
A
S
Q
--
N
I
E
K
C
V
R
RCGL
E
--
V
D
D
I
I
L
E
Q
L
A
S
--
A
--
Y
---
S
--
V
LT--E-------D-------EKEL
G
V
C
L
V
DIGGG
T
T
D
I
A
I
F
T--EGA
I
R
---
H
-----
T
A
V
I
PIA--------GDQ
V
T
N
D
I
-------------------
A
M
A
LRT-------------------
P
-------------------
T
Q
Y
A
E
E
I
K
----------------
I
R
---
Y
-------
A
C
A
L
A
K
LAGAG---
E
T
---
I
KVP------------SV------GDR
P
P
----------
R
E
L
S
R
Q
A
L
A
E
V
VE
P
R
Y
D
E
-------
L
F
T
L
V
Q
A
E
L
R
RSG
Y
E
-DLIPA--
G
I
V
L
TGGT
S
K
M
E
G
A
V
E
L
A
E
E
I
F
H-M
P
V
RLGVPY-----S---V
K
G
L
--------
T
D
V
V
RNP--------
I
Y
ST
G
V
G
L
L
M
Y
G
L
QKQSDG
M
S
M
S
VSGSSYSSDEPK
A
P
V
-------------
L
E
R
L
K
R
W
VQGNF---------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
95.64
25%
-107
- C2 -
3WT0
1
FTSA_STAAW
A:
[20-395]
-----
E
E
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
-
G
E
K
F
H
-
N
G
I
N
V
I
----
G
T
G
Q
T
Y
T
------------
S
-
G
I
K
N
G
-
L
I
-
D
D
-
F
D
I
A
R
---
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
K
E
-
V
F
L
K
-----
L
P
--------
I
IG
T
E
V
Y
D
E
------
S
N
E
I
--
D
F
Y
E
D
T
E
I
N
G
S
H
I
E
-
K
-
V
L
-----
E
--
G
-
I
R
E
K
N
D
V
Q
----
E
--
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
L
K
V
E
A
G
-
V
I
A
I
Q
K
------
S
I
L
I
--
N
M
I
K
C
V
E
A
C
G
V
D
--
V
L
D
V
Y
S
D
A
Y
N
Y
--
G
--
S
---
I
--
L
T
A
----------
T
-------
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
--
R
G
E
L
V
---
D
-----
A
D
S
I
E
M
A
--------
G
R
D
I
T
D
D
I
-------------------
A
Q
G
L
N
T
-------------------
S
-------------------
Y
E
T
A
E
K
V
K
----------------
H
Q
---
Y
-------
G
H
A
F
Y
D
S
A
S
D
Q
---
D
I
---
F
T
V
E
------------
Q
V
------
D
S
D
E
T
----------
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
-------
I
F
F
E
V
F
D
V
L
Q
D
L
G
L
T
--
K
V
N
G
--
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
-
E
K
V
R
I
H
T
P
S
-----
Q
---
M
-------------
G
I
R
K
P
--------
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
93.72
25%
-102
- C2 -
3WQT
4
FTSA_STAAR
A:
[20-393]
-------
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
-
G
E
K
F
H
-
N
G
I
N
V
I
----
G
T
G
Q
T
Y
T
------------
S
-
G
I
K
N
G
-
L
I
-
D
D
-
F
D
I
A
R
---
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
K
E
-
V
F
L
K
-----
L
P
--------
I
IG
T
E
V
Y
D
E
------
S
N
E
I
--
D
F
YE
D
T
E
I
N
G
S
H
I
E
-
K
-
V
L
-----
E
--
G
-
I
R
E
----
Q
----
E
--
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
L
K
V
E
A
G
-
V
I
A
I
Q
K
------
S
I
L
I
--
N
M
I
K
C
V
E
A
C
G
V
D
--
V
L
D
V
Y
S
D
A
Y
N
Y
--
G
--
S
---
I
--
L
T
---
A
-------
T
-------
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
--
R
G
E
L
V
---
D
-----
A
D
S
I
E
M
A
--------
G
R
D
I
T
D
D
I
-------------------
A
Q
G
L
N
T
-------------------
S
-------------------
Y
E
T
A
E
K
V
K
----------------
H
Q
---
Y
-------
G
H
A
F
Y
D
S
A
S
D
Q
---
D
I
---
F
T
V
E
------------
Q
V
------
D
S
D
E
T
----------
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
-------
I
F
F
E
V
F
D
V
L
Q
D
L
G
L
T
--
K
V
N
G
--
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
-
E
K
V
R
I
H
T
P
S
-----
Q
----------------
M
G
I
R
K
P
--------
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.94
29%
-108
- C2 -
3WT0
1
FTSA_STAAW
A:
[25-367]
----------
V
S
I
D
I
G
S
S
S
V
K
T
I
V
-
G
E
K
F
H
N
G
-
I
N
V
I
----
G
T
G
Q
T
Y
T
------------
S
-
G
I
K
N
G
-
L
I
-
D
D
-
F
D
I
A
R
---
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
K
E
-
V
F
L
K
L
P
---
I
I
--------
G
--
T
E
V
Y
D
-
E
S
--
N
E
I
D
F
Y
--
E
---
D
T
E
I
N
G
S
H
I
E
-
K
-
V
L
-----
E
--
G
-
I
R
E
K
N
D
V
Q
----
E
--
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
--
R
H
S
L
K
V
E
-
A
G
V
I
A
I
------
Q
K
S
I
L
I
N
M
I
K
C
V
E
A
C
G
V
D
--
V
L
D
V
----
Y
S
D
--
A
--
Y
N
Y
G
S
--
I
L
T
--
A
-------
T
-------
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
--
R
G
E
L
V
---
D
-----
A
D
S
I
E
M
A
--------
G
R
D
I
T
D
D
I
-------------------
A
Q
G
L
N
T
-------------------
S
-------------------
Y
E
T
A
E
K
V
K
----------------
H
Q
---
Y
-------
G
H
A
F
Y
D
S
A
S
D
Q
---
D
I
---
F
T
V
E
------------
Q
V
------
D
S
D
E
T
----------
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
-------
I
F
F
E
V
F
D
V
L
Q
D
L
G
L
T
-
K
-
V
N
G
--
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
-
E
K
V
R
I
H
T
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.95
29%
-105
- C2 -
3WQU
1
FTSA_STAAR
A:
[23-365]
----------
V
S
I
D
I
G
S
S
S
V
K
T
I
V
-
G
E
K
F
H
N
G
-
I
N
V
I
----
G
T
G
Q
T
Y
T
------------
S
-
G
I
K
N
G
-
L
I
-
D
D
-
F
D
I
A
R
---
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
K
E
-
V
F
L
K
L
P
---
I
I
--------
G
--
T
E
V
Y
D
-
E
S
--
N
E
I
D
F
Y
--
E
---
D
T
E
I
N
G
S
H
I
E
-
K
-
V
L
-----
E
--
G
-
I
R
E
----
Q
----
E
--
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
--
R
H
S
L
K
V
E
-
A
G
V
I
A
I
------
Q
K
S
I
L
I
N
M
I
K
C
V
E
A
C
G
V
D
--
V
L
D
V
----
Y
S
D
--
A
--
Y
N
Y
G
S
--
I
L
T
--
A
-------
T
-------
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
--
R
G
E
L
V
---
D
-----
A
D
S
I
E
M
A
--------
G
R
D
I
T
D
D
I
-------------------
A
Q
G
L
N
T
-------------------
S
-------------------
Y
E
T
A
E
K
V
K
----------------
H
Q
---
Y
-------
G
H
A
F
Y
D
S
A
S
D
Q
---
D
I
---
F
T
V
E
------------
Q
V
------
D
S
D
E
T
----------
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
-------
I
F
F
E
V
F
D
V
L
Q
D
L
G
L
T
-
K
-
V
N
G
--
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
-
E
K
V
R
I
H
T
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
90.85
19%
-102
- C2 -
1E4F
-
?
T:
[7-390]
------
T
V
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
-
L
G
K
R
-
D
Q
E
W
E
A
L
----
A
F
S
S
V
K
S
------------
R
-
G
L
D
E
G
-
E
I
-
K
D
-
A
I
A
F
K
---
E
S
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
L
R
S
D
F
V
I
S
-----
F
S
--------
S
--
V
S
F
E
R
E
D
T
--
V
I
E
R
D
F
GE
E
---
K
R
S
I
T
L
D
I
L
S
-
E
-
M
Q
-----
S
--
E
-
A
L
E
K
L
K
E
N
----
G
--
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
L
D
M
K
A
S
-
K
I
A
I
E
Y
T
-
S
I
V
V
P
L
------
K
V
Y
E
--
M
F
Y
N
F
L
Q
D
T
V
K
S
--
P
F
Q
L
K
S
S
L
V
S
T
--
A
--
E
---
G
--
V
L
T
--
T
-------
P
-------
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
--
N
G
V
P
I
---
K
-----
I
S
Y
V
P
V
G
--------
M
K
H
V
I
K
D
V
-------------------
S
A
V
L
D
T
-------------------
S
-------------------
F
E
E
S
E
R
L
I
----------------
I
T
---
H
-------
G
N
A
V
Y
N
D
L
K
-
E
---
E
E
---
I
Q
Y
R
------------
G
L
------
D
G
N
T
I
----------
K
T
T
T
A
K
K
L
S
V
I
I
H
A
R
L
R
E
-------
I
M
S
K
S
K
K
F
F
R
E
V
E
A
K
-
I
G
I
P
G
--
G
V
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
-
S
P
V
R
T
G
C
Y
A
NSDRP
S
---
I
I
N
A
--------
D
E
V
A
N
D
P
--------
S
F
A
A
A
F
G
N
V
F
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.23
29%
-103
- C2 -
3WQT
3
FTSA_STAAR
A:
[23-365]
----------
V
S
I
D
I
G
S
S
S
V
K
T
I
V
-
G
E
K
F
H
N
G
-
I
N
V
I
----
G
T
G
Q
T
Y
T
------------
S
-
G
I
K
N
G
-
L
I
-
D
D
-
F
D
I
A
R
---
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
K
E
-
V
F
L
K
L
P
---
I
I
--------
G
--
T
E
V
Y
D
-
E
S
--
N
E
I
D
F
Y
--
E
---
D
T
E
I
N
G
S
H
I
E
-
K
-
V
L
-----
E
--
G
-
I
R
E
----
Q
----
E
--
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
--
R
H
S
L
K
V
E
-
A
G
V
I
A
I
------
Q
K
S
I
L
I
N
M
I
K
C
V
E
A
C
G
V
D
--
V
L
D
V
----
Y
S
D
--
A
--
Y
N
Y
G
S
--
I
L
T
--
A
-------
T
-------
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
--
R
G
E
L
V
---
D
-----
A
D
S
I
E
M
A
--------
G
R
D
I
T
D
D
I
-------------------
A
Q
G
L
N
T
-------------------
S
-------------------
Y
E
T
A
E
K
V
K
----------------
H
Q
---
Y
-------
G
H
A
F
Y
D
S
A
S
D
Q
---
D
I
---
F
T
V
E
------------
Q
V
------
D
S
D
E
T
----------
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
-------
I
F
F
E
V
F
D
V
L
Q
D
L
G
L
T
-
K
-
V
N
G
--
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
-
E
K
V
R
I
H
T
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.97
23%
-95
- C2 -
4A2B
2
?
A:
[7-359]
------
T
V
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
--
R
D
Q
E
W
E
A
L
----
A
F
S
S
V
K
S
------------
R
-
G
L
D
E
G
-
E
I
-
K
D
-
A
I
A
F
K
---
E
S
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
L
R
S
-
D
F
V
------
I
S
--------
F
--
S
S
V
-
S
F
E
R
--
E
D
T
V
I
E
--
R
---
D
F
G
E
E
K
R
S
I
T
L
D
-
I
L
-----
S
--
E
-
M
Q
S
E
A
L
E
K
L
K
E
N
G
--
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
L
D
M
K
A
S
-
K
I
A
I
E
Y
T
-
S
I
V
V
P
L
------
K
V
Y
E
--
M
F
Y
N
F
L
Q
D
T
V
K
S
--
P
F
Q
L
K
S
S
L
V
S
T
--
A
--
E
---
G
--
V
L
T
--
T
-------
P
-------
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
--
N
G
V
P
I
---
K
-----
I
S
Y
V
P
V
G
--------
M
K
H
V
I
K
D
V
-------------------
S
A
V
L
D
T
-------------------
S
-------------------
F
E
E
S
E
R
L
I
----------------
I
T
---
H
-------
G
N
A
V
Y
N
D
L
K
E
----
E
E
---
I
Q
Y
R
------------
G
L
------
D
G
N
T
I
----------
K
T
T
T
A
K
K
L
S
V
I
I
H
A
R
L
R
E
I
M
S
K
S
K
K
F
F
R
E
V
E
A
K
I
V
E
E
G
-
E
-
I
G
I
P
G
--
G
V
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
-
S
P
V
R
T
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.13
23%
-100
- C2 -
1E4F
-
?
T:
[7-359]
------
T
V
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
--
R
D
Q
E
W
E
A
L
----
A
F
S
S
V
K
S
------------
R
-
G
L
D
E
G
-
E
I
-
K
D
-
A
I
A
F
K
---
E
S
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
L
R
S
-
D
F
V
------
I
S
--------
F
--
S
S
V
-
S
F
E
R
--
E
D
T
V
I
E
--
R
---
D
F
G
E
E
K
R
S
I
T
L
D
-
I
L
-----
S
--
E
-
M
Q
S
E
A
L
E
K
LKEN
G
--
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
L
D
M
K
A
S
-
K
I
A
I
E
Y
T
-
S
I
V
V
P
L
------
K
V
Y
E
--
M
F
Y
N
F
L
Q
D
T
V
K
S
--
P
F
Q
L
K
S
S
L
V
S
T
--
A
--
E
---
G
--
V
L
T
--
T
-------
P
-------
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
--
N
G
V
P
I
---
K
-----
I
S
Y
V
P
V
G
--------
M
K
H
V
I
K
D
V
-------------------
S
A
V
L
D
T
-------------------
S
-------------------
F
E
E
S
E
R
L
I
----------------
I
T
---
H
-------
G
N
A
V
Y
N
D
L
K
E
----
E
E
---
I
Q
Y
R
------------
G
L
------
D
G
N
T
I
----------
K
T
T
T
A
K
K
L
S
V
I
I
H
A
R
L
R
E
IMSKSKK
F
F
R
E
V
E
A
K
--------
I
G
I
P
G
--
G
V
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
-
S
P
V
R
T
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.05
22%
-102
- C2 -
1E4G
2
?
T:
[9-359]
--------
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
--
R
D
Q
E
W
E
A
L
----
A
F
S
S
V
K
S
------------
R
-
G
L
D
E
G
-
E
I
-
K
D
-
A
I
A
F
K
---
E
S
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
L
R
S
-
D
F
V
------
I
S
--------
F
--
S
S
V
-
S
F
E
R
--
E
D
T
V
I
E
--
R
---
D
F
G
E
E
K
R
S
I
T
L
D
-
I
L
-----
S
--
E
-
M
Q
S
E
A
L
E
K
LKEN
G
--
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
L
D
M
K
A
S
-
K
I
A
I
E
Y
T
-
S
I
V
V
P
L
------
K
V
Y
E
--
M
F
Y
N
F
L
Q
D
T
V
K
S
--
P
F
Q
L
K
S
S
L
V
S
T
--
A
--
E
---
G
--
V
L
T
--
T
-------
P
-------
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
--
N
G
V
P
I
---
K
-----
I
S
Y
V
P
V
G
--------
M
K
H
V
I
K
D
V
-------------------
S
A
V
L
D
T
-------------------
S
-------------------
F
E
E
S
E
R
L
I
----------------
I
T
---
H
-------
G
N
A
V
Y
N
D
L
K
E
----
E
E
---
I
Q
Y
R
------------
G
L
------
D
G
N
T
I
----------
K
T
T
T
A
K
K
L
S
V
I
I
H
A
R
L
R
E
IMSKSKK
F
F
R
E
V
E
A
K
---------
G
I
P
G
--
G
V
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
-
S
P
V
R
T
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.92
23%
-95
- C2 -
4A2A
2
?
A:
[7-359]
------
T
V
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
------
W
E
A
L
----
A
F
S
S
V
K
S
------------
R
-
G
L
D
E
G
-
E
I
-
K
D
-
A
I
A
F
K
---
E
S
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
L
R
S
-
D
F
V
------
I
S
--------
F
--
S
S
V
-
S
F
E
R
--
E
D
T
V
I
E
--
R
---
D
F
G
E
E
K
R
S
I
T
L
D
-
I
L
-----
S
--
E
-
M
Q
S
E
A
L
E
K
L
KEN
G
--
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
L
D
M
K
A
S
-
K
I
A
I
E
Y
T
-
S
I
V
V
P
L
------
K
V
Y
E
--
M
F
Y
N
F
L
Q
D
T
V
K
S
--
P
F
Q
L
K
S
S
L
V
S
T
--
A
--
E
---
G
--
V
L
T
--
T
-------
P
-------
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
--
N
G
V
P
I
---
K
-----
I
S
Y
V
P
V
G
--------
M
K
H
V
I
K
D
V
-------------------
S
A
V
L
D
T
-------------------
S
-------------------
F
E
E
S
E
R
L
I
----------------
I
T
---
H
-------
G
N
A
V
Y
N
D
L
K
E
----
E
E
---
I
Q
Y
R
------------
G
L
------
D
G
N
T
I
----------
K
T
T
T
A
K
K
L
S
V
I
I
H
A
R
L
R
E
I
M
S
K
S
K
K
F
F
R
E
V
E
A
K
----------
I
P
G
--
G
V
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
-
S
P
V
R
T
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
85.50
24%
-76
- C2 -
2QXL
3
HSP7F_YEAST
A:
[2-656]
--------
T
P
F
G
L
D
L
G
N
N
N
S
V
L
A
V
-
A
R
---
N
R
G
I
D
I
V
V
N
EV
S
N
R
S
T
P
S
V
V
G
F
G
PK
N
R
Y
L
G
E
-
T
G
K
N
K
-
Q
T
-
S
N
-
I
K
N
T
V
---
A
N
L
K
R
I
I
-------
G
L
D
Y
H
H
-
P
D
F
E
-----
Q
E
--------
S
--
K
H
F
T
S
K
L
V
--
E
L
D
D
K
K
--
T
---
G
A
E
V
R
F
A
G
E
K
-
H
-
V
F
-----
S
--
A
-
T
Q
L
A
A
M
F
I
----
D
---
K
V
K
D
T
V
K
Q
D
T
--------------------
K
A
N
I
T
-
D
V
C
I
A
V
P
PWYT
E
E
Q
R
Y
--
N
I
A
D
A
A
R
I
A
G
L
N
--
P
V
R
I
V
N
D
V
T
A
A
--
G
--
V
---
S
--
Y
G
I
--
F
KTDLPEG
E
-------
E
K
P
R
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
--
F
K
K
-
G
---
Q
-----
L
K
V
L
G
T
A
--------
C
D
K
H
F
G
G
R
-------------------
D
F
D
L
A
I
-------------------
T
-------------------
E
H
F
A
D
E
F
K
----------------
T
K
---
Y
KIDIREN
P
K
A
Y
N
R
I
L
T
A
A
---
E
K
---
L
K
K
V
L
S
A
N
T
N
A
P
F
S
V
E
S
V
MN----
D
V
D
V
S
----------
S
Q
L
S
R
E
E
L
E
E
L
V
K
P
L
L
E
R
-------
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
-
A
E
E
V
D
--
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
G
-
K
P
L
S
T
T
L
N
Q
-----
D
E
A
I
A
K
G
A
--------
A
F
I
C
A
I
H
SR
P
F
K
F
E
D
I
H
P
Y
S
V
S
Y
S
W
D
K
Q
V
E
D
E
D
H
M
E
V
F
P
A
G
S
S
F
P
S
T
K
L
I
T
L
N
R
T
G
D
F
S
M
A
A
S
Y
TD
I
T
Q
L
P
P
N
T
P
E
Q
I
A
N
W
E
I
TD
S
V
P
V
K
L
K
L
R
CDPSG
L
H
T
I
E
E
A
Y
T
I
E
DK
T
V
K
K
D
D
L
T
I
V
A
H
T
FGLD
A
K
K
L
N
E
L
I
E
K
E
N
E
M
L
A
Q
D
K
L
V
A
E
T
E
D
R
K
N
T
L
E
E
Y
I
Y
T
L
R
G
K
L
E
EEYAPFAS
D
A
E
K
T
K
L
Q
G
M
L
N
K
A
E
E
W
L
Y
DEGFDSI
K
A
K
Y
I
A
K
Y
E
E
L
A
S
L
G
N
I
I
R
G
R
Y
L
A
K
E
E
E
K
K
Q
A
I
R
S
K
Q
35
HHSearch
76.71
18%
-102
- C2 -
2YCH
3
?
A:
[11-375]
-----
P
R
V
E
A
L
G
L
E
I
G
A
S
A
L
K
L
V
E
-
V
S
G
N
-
P
P
A
L
K
A
L
----
A
S
R
P
T
P
P
------------
G
-
L
L
M
E
G
-
M
V
-
A
E
-
P
A
A
L
A
---
Q
E
I
K
E
L
L
L
E
----
A
R
T
R
K
R
Y
-
V
V
T
A
-----
L
S
--------
N
--
L
A
V
I
L
R
------
P
I
Q
V
-------
P
K
M
P
L
K
E
M
E
-
E
-
A
V
-----
R
W
E
A
-
E
R
Y
I
P
F
P
I
-------
E
V
V
L
D
F
A
P
L
T
P
L
S
E
V
Q
-----------
E
-
G
E
Q
V
Q
V
M
-
V
A
A
A
R
Q
------
E
A
V
A
--
G
V
L
E
A
L
R
G
A
G
L
V
--
P
V
V
L
D
V
K
P
F
A
G
--
L
--
Y
---
P
--
L
E
A
R
L
A
-------
E
-------
E
P
D
R
V
F
L
V
L
D
I
G
A
E
S
T
S
L
V
L
L
R
--
G
D
K
P
L
---
A
-----
V
R
V
L
T
L
S
--------
G
K
D
F
T
E
A
I
-------------------
A
R
S
F
N
L
-------------------
D
-------------------
L
L
A
A
E
E
V
K
----------------
R
T
---
Y
----------------------------------------------------------------------
G
R
I
Y
D
A
I
R
P
V
L
V
E
-------
L
T
Q
E
L
R
R
S
L
E
F
F
R
I
Q
L--
S
P
E
--
V
G
Y
L
L
G
G
G
S
K
L
R
G
L
A
S
L
L
T
D
T
L
G
-
V
N
L
E
P
V
N
P
W
-----
E
---
A
V
A
V
D
PKRFE
S
E
Q
L
Q
E
I
G
P
--------
E
F
A
V
A
L
G
L
A
L
R
G
V
E
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
66.15
18%
-59
* C2 *
3D2F
4
?
A:
[2-392]
-------
S
T
P
F
G
L
D
L
G
N
N
N
S
V
L
A
V
-
A
R
N
---
R
G
I
D
I
V
V
N
EV
S
N
R
S
T
P
S
------------
V
V
G
F
G
P
K
N
R
Y
-
L
G
-
E
T
G
K
N
K
QT
S
N
I
K
N
T
V
A
N
L
K
R
I
I
G
L
D
Y
H
H
-
P
D
F
E
Q
E
S
K
H
F
T
--------
S
--
K
L
V
E
L
D
D
K
K
T
G
A
E
V
R
F
--
A
G
E
-
K
H
V
F
S
A
T
Q
L
A
-
A
-
M
F
I
D
K
V
K
D
--
T
-
V
K
Q
D
T
K
A
N
----
I
--
T
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
------------------------------------
R
Y
--
N
I
A
D
A
A
R
I
A
G
L
N
--
P
V
R
I
V
N
D
V
T
A
A
--
G
--
V
---
S
--
Y
G
I
--
F
-------
K
TDLPEGE
E
K
P
R
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
K
K
G
Q
L
K
V
L
G
T
-----
A
C
D
K
H
F
G
--------
G
R
D
F
D
L
A
I
-------------------
T
E
H
F
A
D
E
F
K
T
K
YKIDIREN
P
K
A
Y
N
R
I
-------------------
L
T
A
A
E
K
L
K
----------------
K
V
---
L
-------
S
A
N
T
------
N
---
A
P
---
F
S
V
E
------------
S
V
MN----
D
V
D
V
S
----------
S
Q
L
S
R
E
E
L
E
E
L
V
K
P
L
L
E
R
-------
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
-
A
E
E
V
D
--
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
G
-
K
P
L
S
T
--
T
--------------------------
L
N
Q
--------
D
E
A
I
A
K
G
A
A
F
I
C
A
I
H
S
P
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
64.37
19%
-74
- C2 -
1DKG
-
DNAK_ECOLI
D:
[3-383]
--------
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
-
M
D
---
G
T
T
P
R
V
L
ENAE
G
D
R
T
T
P
S
------------
I
-
I
A
Y
T
Q
-
D
--------------
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
-----
I
K
RLIGRRFQ
D
--
E
E
V
Q
R
D
V
S
--
I
M
P
F
K
I
--
I
---
A
A
D
N
G
D
A
W
V
E
-
V
--------
K
--
G
---
Q
K
M
A
P
P
----
Q
IS
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
-
Y
F
N
---------
D
A
------
Q
R
Q
A
--
T
K
D
A
G
R
I
-
A
G
L
E
--
V
K
R
I
I
N
E
P
T
A
A
--
A
--
L
---
A
YG
L
D
K
------------------
T
G
N
R
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
--
I
D
E
K
T
---
F
-----
E
V
L
A
---TNGDTHLG
G
E
D
F
D
S
R
L
INYLVEEFKKDQGIDLRND
P
L
A
M
Q
R
-------------------
L
-------------------
K
E
A
A
E
K
A
K
----------------
I
E
LSS-------------------AQQ
T
D
---
V
N
L
P
------------
Y
I
------
T
A
D
A
T
GPKHMNIKVT
R
A
K
L
E
S
L
V
E
D
L
V
N
----
R
-------
S
I
E
L
L
K
V
A
L
Q
D
A
G
---
L
S
V
S
D
ID
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
G
---------------------
K
E
--------
P
R
K
D
V
N
P
--------
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Fugue
62.96
16%
-75
- C2 -
2YCH
3
?
A:
[11-375]
-----
P
R
V
E
A
L
G
L
E
I
G
A
S
A
L
K
L
V
E
-
V
S
---
G
N
P
P
A
L
K
----
A
L
A
S
R
P
----------------
T
P
P
G
-
L
L
M
E
G
M
V
A
E
-
P
---
A
A
L
A
Q
E
I
K
E
L
L
L
E
A
R
T
R
K
R
Y
-
V
V
T
A
-----
L
S
--------
N
--
L
A
V
---------------------
I
L
R
P
I
Q
V
P
-
K
M
P
L
-----
K
--
E
M
E
E
A
V
R
W
E
A
----
E
--
R
Y
I
P
F
P
I
--
E
V
V
L
D
F
A
P
L
T
P
L
S
E
V
Q
E
G
----
E
Q
V
Q
V
M
V
A
A
A
R
Q
------
E
A
V
A
--
G
V
L
E
A
L
R
G
A
G
L
V
PV
V
L
D
V
K
P
F
A
G
L
Y
--
P
--
L
---
E
--
A
R
L
--
A
-------
E
-------
E
P
D
R
V
F
L
V
L
D
I
G
A
E
S
T
S
L
V
L
L
R
--
G
D
K
P
L
---
A
-----
V
R
V
L
T
L
S
--------
G
K
D
F
T
E
A
I
-------------------
A
R
S
F
N
L
-------------------
D
-------------------
L
L
A
A
E
E
V
K
----------------
R
T
-------------------------------------------------------------------------
Y
G
R
I
Y
D
A
I
R
P
V
L
V
E
-------
L
T
Q
E
L
R
R
S
L
E
F
F
R
I
Q
-
L
S
P
E
---
V
G
Y
L
L
G
G
G
S
K
L
R
G
L
A
S
L
L
T
D
T
L
G
-
V
N
L
E
P
V
N
P
W
-----
E
---
A
V
A
V
--------
D
P
K
R
F
E
------------------
S
E
Q
L
Q
E
I
G
P
E
F
A
V
A
L
G
L
A
L
R
G
V
E
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
60.66
18%
-63
- C2 -
1T6C
11
?
A:
[10-315]
-----
P
I
M
R
V
A
S
I
D
I
G
S
Y
S
V
R
L
T
I
-
A
Q
I
K
------------------------------------
D
G
-
K
L
-
S
I
-
I
L
E
R
G
---
R
I
T
S
L
G
T
K
V
K
E
T
------------------------------------------------------
G
R
L
Q
E
D
R
I
E
-
E
-
T
I
-----
Q
--
V
-
L
K
E
Y
K
K
L
I
----
D
--
E
F
---------------------
K
V
E
R
V
-
K
A
V
A
T
E
A
-
I
R
R
-
A
K
------
N
A
E
E
--
F
L
E
R
V
K
R
E
V
G
L
V
--
V
E
V
I
T
P
E
Q
E
G
R
Y
A
Y
--
L
---
A
--
V
A
Y
--
S
-------
L
-------
K
P
E
G
E
V
C
V
V
D
Q
G
G
G
S
T
E
Y
V
F
G
K
--
G
Y
K
V
R
---
E
-----
V
I
S
L
P
I
G
--------
I
V
N
L
T
E
T
F
-------------------
F
K
Q
D
P
P
-------------------
T
-------------------
E
E
E
V
K
R
F
F
----------------
E
F
---
L
-------
E
K
E
L
S
K
V
K
K
P
V
---
D
T
---
I
V
G
L
------------
G
--------------------------------------
G
T
-------
I
T
T
L
A
A
L
E
Y
N
V
Y
P
Y
D
-
P
Q
K
V
H
--
G
K
V
L
T
-----
Y
G
Q
I
K
K
W
F
D
T
F
K
E
-
I
P
S
E
E
R
S
K
R
---------
F
R
Q
V
---------
E
D
R
R
A
K
--------
V
I
L
A
G
I
G
I
F
L
K
T
L
E
I
F
E
K
D
-
C
L
I
V
S
----
D
W
G
L
R
E
G
V
L
-------------
V
S
E
V
L
K
E
N
H
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
58.79
24%
-91
- C2 -
4IO8
1
HS71A_HUMAN
A:
[165-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
N
--
V
L
R
I
I
N
E
P
T
A
A
--
A
I
A
Y
---
G
--
L
D
R
--
T
-------
G
-------
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
-----------
V
K
A
T
A
--------
G
D
T
H
L
G
G
E
-------------------
D
F
D
N
R
L
-------------------
V
-------------------
N
H
F
V
E
E
F
K
R
K
HKKDISQN
K
R
A
V
R
R
L
R
---
T
-------
A
C
E
R
A
K
R
T
L
S
S
---
S
T
Q
A
S
L
E
I
D
------------
S
L
FE----
G
I
D
F
Y
----------
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
-------
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
-
K
A
Q
I
H
--
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
57.61
24%
-92
- C2 -
3D2F
1
HS71A_HUMAN
B:
[165-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
N
--
V
L
R
I
I
N
E
P
T
A
A
--
A
I
A
Y
---
G
--
L
D
R
--
T
-------
G
-------
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
-----------
V
K
A
T
A
--------
G
D
T
H
L
G
G
E
-------------------
D
F
D
N
R
L
-------------------
V
-------------------
N
H
F
V
E
E
F
K
R
K
HKKDISQN
K
R
A
V
R
R
L
R
---
T
-------
A
C
E
R
A
K
R
T
L
S
S
---
S
T
Q
A
S
L
E
I
D
------------
S
L
FE----
G
I
D
F
Y
----------
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
-------
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
-
K
A
Q
I
H
--
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
56.46
22%
-69
- C2 -
3I33
3
HSP72_HUMAN
A:
[174-402]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
--
A
T
K
D
A
G
T
I
T
G
L
N
--
V
L
R
I
I
N
E
P
T
A
A
--
A
--
I
---
A
--
Y
G
L
--
D
-------
K
KGCA---
G
G
E
K
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
G
I
F
E
---
V
K
S
T
--
A
G
D
T
H
L
G
--------
G
E
D
F
D
N
R
M
-------------------
V
S
H
L
A
E
E
F
K
R
K
HKKDIGPN
K
R
A
V
R
R
L
-------------------
R
T
A
C
E
R
A
K
----------------
R
T
---
L
-------
S
S
S
T
Q
---------
A
S
---
I
E
I
D
------------
S
L
YE----
G
V
D
F
Y
----------
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
-------
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
-
K
G
Q
I
Q
--
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
--
K
S
--------------------------
I
N
P
--------
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
54.15
22%
-55
- C2 -
2V7Y
2
DNAK_GEOKA
A:
[125-352]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
--
A
T
K
D
A
G
R
I
A
G
L
E
--
V
E
R
I
I
N
E
P
T
A
A
--
A
--
L
---
A
--
Y
G
L
--
D
-------
K
-------
E
E
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
--
L
G
D
G
V
---
F
E
V
K
A
T
A
G
D
N
H
L
G
--------
G
D
D
F
D
Q
V
I
-------------------
I
D
Y
L
V
N
-------------------
Q
F
K
Q
E
HGIDLSKD
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
----------------
K
E
---
L
-------
S
G
V
T
Q
---------
T
Q
---
I
S
L
P
------------
F
I
SANEN
G
P
L
H
L
E
----------
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
-------
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
-
P
A
D
I
D
--
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
G
-
K
E
P
H
K
--
G
--------------------------
V
N
P
--------
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------