@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4435: (2016-02-27 )
MTTMIPRTLFSSDHELFRDSVRKFLEQEAVPFHHQWEKDGHVDRALWNKAGEAGMLCSHLPEEYGGMGADFLYSAVVIEEIGRAGLTGIGFSLHSDIAAPYILHYGSEALKRKYLPKLVSGEMVAAIAMTEPGAGSDLQGVKTTAVLDGDEYVINGSKTFITNGFLADLVIVVAKTDPKAGAKGISLFVVEAGTPGFSKGKRLEKVGMKAQDTSELFFQDVRIPRENLLGKDGQGFIYLMQELPQERLTVGIGALASAEAALQWTLDYTRERKAFGKSVADFQNTRFKLAEMATEIQVGRVFVDRCMELHLQGKLDVPTAAMCKYWTTDLQCKVLDECVQLHGGYGFMWEYPVARAWADARVQRIYAGTNEIMKEIIARAL
Atome Classification :
(32 SA)
--------------.........10........20........30......-..40.-.--......50........60........---70--.........80--..--.-.--.-...-90-..--...-.-.--..100.......110.......120.......130.......140.....--.-.150........160.......170......-.--180--..---.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......-310..-..--------------...320.......330.--......340.......350.......360.......370.......380--------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MTTMI
P
R
T
LFSS
D
H
E
L
F
R
D
S
V
R
K
F
L
E
QEAVPFHHQWE-KDGH
V
-
D
--
R
A
L
W
NKAGEA
G
M
L
C
S
HL
P
E
E
YGGM
G
A
---
D
---
F
L
Y
S
A
V
V
I
E
E
I
--
G
R--A-G--L-TGI-G--F
S
--
L
H
S-D-I--A
A
P
Y
I
L
HY
G
S
E
A
L
K
R
K
Y
L
P
K
LVSG
E
M
V
A
A
I
A
MTEPGAGSDLQG
V
K
T
T
A
V
L--D-GD-
E
Y
V
INGS
K
T
F
ITNG
F
L
A
D
L
V
I
V
V
AKTDP-K--A----GA---K
G
I
S
L
F
V
V
EAGTPGFSKG
K
R
L
E
K
VGMKAQ
D
T
S
E
L
F
F
Q
D
VRI
P
R
E
NLLGKDG
Q
G
F
I
Y
L
M
Q
EL
P
Q
E
R
L
T
V
G
I
G
A
L
A
S
A
E
A
A
L
Q
W
T
L
D
Y
T
R
E
R
K
A
FG
K
S
V
A
D
F
Q
N
T
R
F
K
L
A
E
M
A
T
E
I
Q
V
G
R
V
F
V
D
R
C
M
E
L
-
H
LQGK-LD--------------V
P
T
A
A
M
C
K
YWTTD
L
Q
C
K
--
V
L
D
E
C
V
Q
L
HGGYG
F
M
W
EY
P
V
A
R
A
W
A
D
A
R
V
Q
R
I
YA
G
T
N
E
I
M
K
E
I
I
A
RAL---------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
98.68
55%
-102
- C2 -
2PG0
2
?
A:
[7-383]
--------------------
A
R
Y
L
R
E
E
H
H
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
-
K
R
G
I
I
-
P
--
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
---
D
---
F
A
Y
S
V
V
I
N
E
E
L
--
E
K
--
V
-
G
--
S
-
S
L
V
-
G
--
I
G
--
L
H
N
-
D
-
I
--
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
--
D
-
G
D
-
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
P
-
Q
--
A
KP--
P
H
---
R
G
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
-
E
E
H
M
A
G
K
-
Q
I
--------------
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
--
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.32
54%
-101
- C2 -
2PG0
2
?
A:
[6-383]
------------------
T
A
R
Y
L
-
R
E
E
H
H
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
-
K
R
G
I
I
-
P
--
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
---
D
---
F
A
Y
S
V
V
I
N
E
E
L
--
E
K
--
V
-
G
--
S
-
S
L
V
-
G
--
I
G
--
L
H
N
-
D
-
I
--
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
--
D
-
G
D
-
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
P
-
Q
--
A
----
K
P
PH-
R
G
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
E
E
-
H
M
A
G
K
-
Q
I
--------------
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
--
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
95.84
54%
-101
- C2 -
2PG0
2
?
B:
[8-383]
--------------------
R
Y
L
-
R
E
E
H
H
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
-
K
R
G
I
I
-
P
--
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
---
D
---
F
A
Y
S
V
V
I
N
E
E
L
--
E
K
--
V
-
G
--
S
-
S
L
V
-
G
--
I
G
--
L
H
N
-
D
-
I
--
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
--
D
-
G
D
-
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
P
-
Q
--
A
----
K
P
PH-
R
G
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
E
E
-
H
M
A
G
K
-
Q
I
--------------
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
--
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
86.89
39%
-98
- C2 -
3R7K
5
?
A:
[25-401]
-------------------
P
E
A
W
T
T
P
E
R
R
A
L
S
Q
M
A
R
S
F
V
E
R
E
I
A
P
K
L
A
E
W
E
-
H
V
G
E
I
-
P
--
R
D
L
H
L
N
A
A
E
V
G
L
L
G
I
G
F
P
E
E
V
G
G
S
G
G
---
N
---
A
I
D
S
A
L
V
T
E
A
I
--
L
A
--
A
-
G
GS
T
-
G
V
C
A
A
--
L
F
--
T
H
--
G
-
I
--
A
L
P
H
I
A
A
N
G
S
D
A
L
I
E
R
Y
V
R
P
T
L
A
G
K
M
I
G
S
L
G
V
T
E
P
G
A
G
S
D
V
A
N
L
R
T
R
A
V
R
--
E
-
G
D
-
T
Y
V
V
N
G
A
K
T
F
I
T
S
G
V
R
A
D
F
V
T
T
A
V
R
T
G
G
-
P
-------
G
Y
---
G
G
V
S
L
L
V
I
D
K
N
S
P
G
F
E
V
S
R
R
L
D
K
M
G
W
R
C
S
D
T
A
E
L
S
F
V
D
V
R
V
P
A
D
N
L
V
G
A
E
N
S
G
F
L
Q
I
M
Q
Q
F
Q
A
E
R
L
G
I
A
V
Q
A
Y
A
T
A
G
R
A
L
D
L
A
K
S
W
A
R
E
R
E
T
F
G
R
P
L
T
G
R
Q
I
I
R
H
K
L
A
E
M
A
R
Q
V
D
V
A
C
T
Y
T
R
A
V
M
-
Q
R
W
L
A
G
E
-
D
V
--------------
V
A
E
V
S
M
A
K
N
T
A
V
Y
A
C
D
Y
--
V
V
N
E
A
V
Q
I
F
G
G
M
G
Y
M
R
E
S
E
I
E
R
H
Y
R
D
C
R
I
L
G
I
G
G
G
T
N
E
I
M
N
E
V
I
A
K
R
I
---------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
86.19
35%
-96
* C2 *
2VIG
5
ACADS_HUMAN
A:
[6-378]
-----------------------
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
-
K
E
H
L
F
-
P
--
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
L
A
Y
A
I
A
M
E
E
I
--
S
R
--
G
-
C
A
S
T
-
G
V
I
----
M
S
--
V
N
N
-
S
-
L
--
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
--
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
R
-
A
--
L
----
Q
N
---
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
-
M
L
K
D
N
K
K
-
P
F
--------------
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
--
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
---------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.91
39%
-94
- C2 -
3R7K
5
?
A:
[25-401]
-------------------
P
E
A
W
T
T
P
E
R
R
A
L
S
Q
M
A
R
S
F
V
E
R
E
I
A
P
K
L
A
E
W
E
-
H
V
G
E
I
-
P
--
R
D
L
H
L
N
A
A
E
V
G
L
L
G
I
G
F
P
E
E
V
G
G
S
G
G
---
N
---
A
I
D
S
A
L
V
T
E
A
I
L
-
A
A
--
G
-
G
--
S
-
T
G
V
-
C
--
A
A
--
L
F
T
-
H
G
I
--
A
L
P
H
I
A
A
N
G
S
D
A
L
I
E
R
Y
V
R
P
T
L
A
G
K
M
I
G
S
L
G
V
T
E
P
G
A
G
S
D
V
A
N
L
R
T
R
A
V
R
--
E
-
G
D
-
T
Y
V
V
N
G
A
K
T
F
I
T
S
G
V
R
A
D
F
V
T
T
A
V
R
T
G
--
G
--
P
----
G
Y
---
G
G
V
S
L
L
V
I
D
K
N
S
P
G
F
E
V
S
R
R
L
D
K
M
G
W
R
C
S
D
T
A
E
L
S
F
V
D
V
R
V
P
A
D
N
L
V
G
A
E
N
S
G
F
L
Q
I
M
Q
Q
F
Q
A
E
R
L
G
I
A
V
Q
A
Y
A
T
A
G
R
A
L
D
L
A
K
S
W
A
R
E
R
E
T
F
G
R
P
L
T
G
R
Q
I
I
R
H
K
L
A
E
M
A
R
Q
V
D
V
A
C
T
Y
T
R
A
V
M
Q
R
-
W
L
A
G
E
-
D
V
--------------
V
A
E
V
S
M
A
K
N
-
T
A
V
Y
A
C
D
Y
-
V
V
N
E
A
V
Q
I
F
G
G
M
G
Y
M
R
E
S
E
I
E
R
H
Y
R
D
C
R
I
L
G
I
G
G
G
T
N
E
I
M
N
E
V
I
A
K
R
I
---------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
85.89
36%
-99
- C2 -
4M9A
1
?
B:
[12-385]
----------------------
L
Y
T
E
D
Q
R
M
I
L
D
A
A
R
A
F
C
A
E
V
L
A
P
N
A
A
Q
W
D
-
R
E
S
H
L
-
P
--
D
E
V
V
A
Q
M
G
E
L
G
F
L
G
M
I
V
P
A
D
W
G
G
S
Y
T
---
D
---
Y
V
A
Y
A
L
A
L
E
E
I
--
A
---
A
-
G
--
C
-
A
S
C
-
A
T
L
V
S
--
V
H
N
-
S
-
V
--
G
C
G
P
V
L
N
Y
G
T
T
E
Q
K
E
R
W
L
R
D
L
A
S
G
K
T
V
G
A
F
S
L
T
E
P
H
A
G
S
E
A
H
N
L
R
T
R
A
E
L
--
R
-
D
G
-
K
W
I
L
N
G
S
K
Q
F
V
T
N
G
A
R
A
G
L
A
I
V
F
A
M
T
D
P
-
D
--
E
----
G
K
---
R
G
L
S
A
F
V
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
L
E
N
C
A
I
P
Q
E
N
L
L
G
K
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
T
G
I
A
R
A
A
F
D
R
A
R
R
Y
A
R
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
A
E
K
L
A
N
M
A
T
Q
I
N
A
A
R
L
L
T
H
H
A
A
R
L
-
R
T
A
G
L
-
P
C
--------------
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
A
--
V
C
S
D
A
I
Q
I
H
G
G
Y
G
F
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
85.63
36%
-94
- C2 -
1JQI
4
ACADS_RAT
A:
[14-379]
---------------------------
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
-
K
E
H
L
F
-
P
--
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
---
D
---
Y
L
A
Y
S
I
A
L
E
E
I
--
S
R
G
-
C
-
A
--
S
-
T
G
V
-
I
--
M
S
--
V
N
N
-
S
-
L
--
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
E
--
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
R
-
S
--
R
----
Q
N
---
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
-
K
D
N
K
K
-
P
F
--------------
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
--
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.03
36%
-98
- C2 -
4N5F
10
?
A:
[12-385]
----------------------
L
Y
T
E
D
Q
R
M
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
A
Q
W
D
-
H
D
A
H
L
-
P
--
D
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
S
Y
T
---
D
---
Y
V
A
Y
A
L
A
M
E
E
V
A
A
G
D
--
A
-
A
--
C
-
A
T
M
----
M
S
--
V
H
N
-
S
-
V
--
G
C
G
P
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
R
V
I
G
A
F
C
L
T
E
P
H
A
G
S
E
A
N
N
L
R
T
R
A
E
L
--
R
-
D
G
-
Q
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
P
-
E
--
A
----
G
K
---
R
G
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
-
R
T
A
G
L
-
P
C
--------------
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
--
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
84.52
36%
-100
- C2 -
1IVH
5
IVD_HUMAN
A:
[10-389]
--------------------
I
N
G
L
S
E
E
Q
R
Q
L
R
Q
T
M
A
K
F
L
Q
E
H
L
A
P
K
A
Q
E
I
D
-
R
S
N
E
F
-
K
N
L
R
E
F
W
K
Q
L
G
N
L
G
V
L
G
I
T
A
P
V
Q
Y
G
G
S
G
L
---
G
---
Y
L
E
H
V
L
V
M
E
E
I
--
S
R
--
A
-
S
G
A
V
-
G
L
S
----
Y
G
--
A
H
S
-
N
-
L
--
C
I
N
Q
L
V
R
N
G
N
E
A
Q
K
E
K
Y
L
P
K
L
I
S
G
E
Y
I
G
A
L
A
M
S
E
P
N
A
G
S
D
V
V
S
M
K
L
K
A
E
K
--
K
-
G
N
-
H
Y
I
L
N
G
N
K
F
W
I
T
N
G
P
D
A
D
V
L
I
V
Y
A
K
T
D
L
-
A
AV
P
----
A
S
---
R
G
I
T
A
F
I
V
E
K
G
M
P
G
F
S
T
S
K
K
L
D
K
L
G
M
R
G
S
N
T
C
E
L
I
F
E
D
C
K
I
P
A
A
N
I
L
G
H
E
N
K
G
V
Y
V
L
M
S
G
L
D
L
E
R
L
V
L
A
G
G
P
L
G
L
M
Q
A
V
L
D
H
T
I
P
Y
L
H
V
R
E
A
F
G
Q
K
I
G
H
F
Q
L
M
Q
G
K
M
A
D
M
Y
T
R
L
M
A
C
R
Q
Y
V
Y
N
V
A
-
K
A
C
D
E
G
H
-
C
T
--------------
A
K
D
C
A
G
V
I
L
Y
S
A
E
C
A
T
Q
--
V
A
L
D
G
I
Q
C
F
G
G
N
G
Y
I
N
D
F
P
M
G
R
F
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
V
R
R
L
V
I
G
R
A
F
---------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
84.49
36%
-90
- C2 -
1UKW
2
?
A:
[3-376]
---------------------
F
S
L
T
E
E
Q
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
-
E
K
E
E
V
-
P
--
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
---
K
---
M
L
D
E
V
I
V
G
E
E
L
--
A
Y
--
A
-
C
M
G
I
-
Y
T
I
----
P
M
--
A
S
--
D
-
L
--
G
I
T
P
V
L
L
A
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
I
R
--
Q
-
G
D
-
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
T
V
N
P
-
E
--
L
----
R
H
---
K
G
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
-
W
L
A
D
Q
G
L
-
P
H
--------------
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
--
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
---------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
84.40
36%
-97
- C2 -
4M9A
1
?
C:
[12-385]
----------------------
L
Y
T
E
D
Q
R
M
I
L
D
A
A
R
A
F
C
A
E
V
L
A
P
N
A
A
Q
W
D
-
R
E
S
H
L
-
P
--
D
E
V
V
A
Q
M
G
E
L
G
F
L
G
M
I
V
P
A
D
W
G
G
S
Y
T
---
D
---
Y
V
A
Y
A
L
A
L
E
E
I
--
A
---
A
-
G
--
C
-
A
S
C
-
A
T
L
V
S
--
V
H
N
-
S
-
V
--
G
C
G
P
V
L
N
Y
G
T
T
E
Q
K
E
R
W
L
R
D
L
A
S
G
K
T
V
G
A
F
S
L
T
E
P
H
A
----
H
N
L
R
T
R
A
E
L
--
R
-
D
G
-
K
W
I
L
N
G
S
K
Q
F
V
T
N
G
A
R
A
G
L
A
I
V
F
A
M
T
D
P
-
D
--
E
----
G
K
---
R
G
L
S
A
F
V
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
L
E
N
C
A
I
P
Q
E
N
L
L
G
K
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
T
G
I
A
R
A
A
F
D
R
A
R
R
Y
A
R
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
A
E
K
L
A
N
M
A
T
Q
I
N
A
A
R
L
L
T
H
H
A
A
R
L
-
R
T
A
G
L
-
P
C
--------------
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
A
--
V
C
S
D
A
I
Q
I
H
G
G
Y
G
F
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
84.34
30%
-102
- C2 -
3SWO
5
?
A:
[23-391]
--------------------
D
R
L
L
D
Q
D
E
R
D
I
A
A
T
V
R
Q
F
V
D
T
R
L
K
P
N
V
E
G
W
F
-
E
S
A
T
L
-
P
--
S
E
L
A
K
E
F
G
N
L
G
V
L
G
M
H
L
Q
-
G
Y
G
C
A
G
T
---
N
---
A
V
S
Y
G
L
A
C
M
E
L
--
E
A
--
G
-
D
S
G
F
-
R
S
F
----
V
S
--
V
Q
G
-
S
-
L
--
S
M
F
S
I
Y
R
Y
G
S
E
E
Q
K
N
E
W
L
P
R
L
A
A
G
D
A
I
G
C
F
G
L
T
E
P
D
F
G
S
N
P
A
G
M
R
T
R
A
R
R
--
D
-
G
S
-
D
W
I
L
N
G
T
K
M
W
I
T
N
G
N
L
A
D
V
A
T
V
W
A
Q
T
D
D
---------------
G
I
R
G
F
L
V
P
T
D
T
P
G
F
T
A
N
E
I
H
R
K
L
S
L
R
A
S
V
T
S
E
L
V
L
D
N
V
R
L
P
A
S
A
Q
L
P
L
-
A
E
G
L
S
A
P
L
S
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
S
L
E
T
T
I
A
Y
T
Q
S
R
E
V
F
D
K
P
L
S
N
Y
Q
L
T
Q
E
K
L
A
N
M
T
V
E
L
G
K
G
M
L
L
A
I
H
L
G
-
R
I
K
D
A
E
G
-
V
R
--------------
P
E
Q
I
S
L
G
K
L
N
N
V
R
E
A
I
A
--
I
A
R
E
C
R
T
L
L
G
G
S
G
I
T
L
E
Y
S
P
L
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
L
L
S
I
G
K
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
84.33
38%
-97
- C2 -
3P4T
3
?
B:
[27-399]
------------------------
T
A
E
R
E
A
L
R
K
T
V
R
A
F
A
E
R
E
V
L
P
H
A
H
E
W
E
-
R
A
G
E
I
-
P
--
R
E
L
H
R
K
A
A
E
L
G
L
L
G
A
G
F
P
E
D
A
G
G
S
G
G
---
D
---
G
A
D
P
V
V
I
C
E
E
M
--
H
Y
--
A
-
G
--
S
-
P
G
G
-
V
--
Y
A
SL
F
T
C
-
G
-
I
--
A
V
P
H
M
I
A
S
G
D
Q
R
L
I
D
T
Y
V
R
P
T
L
R
G
E
K
I
G
A
L
A
I
T
E
P
G
G
G
S
D
V
G
H
L
R
T
R
A
D
L
--
D
-
G
D
-
H
Y
V
I
N
G
A
K
T
Y
I
T
S
G
V
R
A
D
Y
V
V
T
A
A
R
T
G
--
G
--
P
----
G
A
---
G
G
V
S
L
I
V
V
D
K
G
T
P
G
F
E
V
T
R
K
L
D
K
M
G
W
R
S
S
D
T
A
E
L
S
Y
T
D
V
R
V
P
V
A
N
L
V
G
S
E
N
T
G
F
A
Q
I
A
A
A
F
V
A
E
R
V
G
L
A
T
Q
A
Y
A
G
A
Q
R
C
L
D
L
T
V
E
W
C
R
N
R
D
T
F
G
R
P
L
I
S
R
Q
A
V
Q
N
T
L
A
G
M
A
R
R
I
D
V
A
R
V
Y
T
R
H
V
V
E
R
-
Q
L
A
G
E
-
T
N
--------------
L
-
I
A
E
V
C
F
A
K
N
T
A
V
E
A
G
EW
V
A
N
Q
A
V
Q
L
F
G
G
M
G
Y
M
A
E
S
E
V
E
R
Q
Y
R
D
M
R
I
L
G
I
G
G
G
T
T
E
I
L
T
S
L
A
A
K
T
L
---------------------------------------------------------------------------------------------------------------------------------------------
103
Fugue
84.18
37%
-95
- C2 -
2Z1Q
2
?
B:
[5-577]
KKLWQKGGGWLLEV
P
E
R
V
Y
T
P
E
D
F
D
E
S
V
K
E
I
A
R
T
T
R
T
F
V
E
R
E
V
L
P
L
L
E
R
M
E
H
G
E
L
E
L
-
N
--
V
P
L
M
R
K
A
G
E
L
G
L
L
A
I
D
V
P
E
E
Y
G
G
L
D
L
---
P
---
K
V
I
S
T
V
V
A
E
E
L
--
S
G
--
S
-
G
--
G
-
F
S
V
-
T
--
Y
G
--
A
H
T
-
S
-
I
--
G
T
L
P
L
V
Y
F
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
G
E
W
I
A
A
Y
C
L
T
E
P
G
S
G
S
D
A
L
A
A
K
T
R
A
T
L
S
E
D
-
G
K
-
H
Y
I
L
N
G
V
K
Q
W
I
S
N
A
G
F
A
H
L
F
T
V
F
A
K
V
D
G
-
E
-------------
H
F
T
A
F
L
V
E
R
D
T
P
G
L
S
F
G
P
E
E
K
K
M
G
I
K
A
S
S
T
R
Q
V
I
L
E
D
V
K
V
P
V
E
N
V
L
G
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
V
Q
F
G
R
P
I
G
R
F
G
L
I
Q
Q
K
L
G
E
M
A
S
R
I
Y
A
A
E
S
A
V
Y
R
T
V
G
L
-
I
D
E
A
L
-
L
G
KKG
P
E
A
V
M
A
G
I
E
E
Y
A
V
E
A
S
I
I
K
V
L
G
S
E
V
L
D
Y
--
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
I
P
G
M
L
LRRAEPED
L
E
L
H
Q
V
Q
N
L
K
K
L
A
L
M
V
A
G
L
A
V
Q
K
YGQGVEEE
Q
E
V
L
G
A
V
A
D
I
L
I
D
A
Y
A
A
E
S
A
L
L
R
A
R
R
L
GGL
A
P
V
L
A
R
I
Y
L
A
Q
A
L
D
R
A
Q
A
G
A
L
S
V
LPRLVEG
D
E
A
R
V
V
Y
S
A
A
R
R
L
T
KREPGD
L
V
A
L
R
R
Q
A
A
E
A
V
L
E
A
GGYPIPR
42
PsiBlast_CBE
83.93
38%
-96
- C2 -
3OIB
7
?
B:
[27-399]
------------------------
T
A
E
R
E
A
L
R
K
T
V
R
A
F
A
E
R
E
V
L
P
H
A
H
E
W
E
-
R
A
G
E
I
-
P
--
R
E
L
H
R
K
A
A
E
L
G
L
L
G
A
G
F
P
E
D
A
G
G
S
G
G
---
D
---
G
A
D
P
V
V
I
C
E
E
M
--
H
Y
--
A
-
G
--
S
-
P
G
G
-
V
--
Y
A
SL
F
T
C
-
G
-
I
--
A
V
P
H
M
I
A
S
G
D
Q
R
L
I
D
T
Y
V
R
P
T
L
R
G
E
K
I
G
A
L
A
I
T
E
P
G
G
G
S
D
V
G
H
L
R
T
R
A
D
L
--
D
-
G
D
-
H
Y
V
I
N
G
A
K
T
Y
I
T
S
G
V
R
A
D
Y
V
V
T
A
A
R
T
G
--
G
--
P
----
G
A
---
G
G
V
S
L
I
V
V
D
K
G
T
P
G
F
E
V
T
R
K
L
D
K
M
G
W
R
S
S
D
T
A
E
L
S
Y
T
D
V
R
V
P
V
A
N
L
V
G
S
E
N
T
G
F
A
Q
I
A
A
A
F
V
A
E
R
V
G
L
A
T
Q
A
Y
A
G
A
Q
R
C
L
D
L
T
V
E
W
C
R
N
R
D
T
F
G
R
P
L
I
S
R
Q
A
V
Q
N
T
L
A
G
M
A
R
R
I
D
V
A
R
V
Y
T
R
H
V
V
E
R
-
Q
L
A
G
E
-
T
N
--------------
L
-
I
A
E
V
C
F
A
K
N
T
A
V
E
A
G
EW
V
A
N
Q
A
V
Q
L
F
G
G
M
G
Y
M
A
E
S
E
V
E
R
Q
Y
R
D
M
R
I
L
G
I
G
G
G
T
T
E
I
L
T
S
L
A
A
K
T
L
---------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
83.78
39%
-91
- C2 -
3R7K
5
?
B:
[25-401]
-------------------
P
E
A
W
T
T
P
E
R
R
A
L
S
Q
M
A
R
S
F
V
E
R
E
I
A
P
K
L
A
E
W
E
-
H
V
G
E
I
-
P
--
R
D
L
H
L
N
A
A
E
V
G
L
L
G
I
G
F
P
E
E
V
G
G
S
G
G
---
N
---
A
I
D
S
A
L
V
T
E
A
I
L-
A
A
--
G
-
G
--
S
-
T
G
V
-
C
--
A
A
--
L
F
T
-
H
G
I
--
A
L
P
H
I
A
A
N
G
S
D
A
L
I
E
R
Y
V
R
P
T
L
A
G
K
M
I
G
S
L
G
V
T
E
P
G
A
G
S
D
V
A
N
L
R
T
R
A
V
R
--
E
-
G
D
-
T
Y
V
V
N
G
A
K
T
F
I
T
S
G
V
R
A
D
F
V
T
T
A
V
R
T
G
--
G
--
P
----
G
Y
---
G
G
V
S
L
L
V
I
D
K
N
S
P
G
F
E
V
S
R
R
L
D
K
M
G
W
R
C
S
D
T
A
E
L
S
F
V
D
V
R
V
P
A
D
N
L
V
G
A
E
N
S
G
F
L
Q
I
M
Q
Q
F
Q
A
E
R
L
G
I
A
V
Q
A
Y
A
T
A
G
R
A
L
D
L
A
K
S
W
A
R
E
R
E
T
F
G
R
P
L
T
G
R
Q
I
I
R
H
K
L
A
E
M
A
R
Q
V
D
V
A
C
T
Y
T
R
A
V
M
Q
R
-
W
L
A
G
E
-
D
V
--------------
V
A
E
V
S
M
A
K
N
-
T
A
V
Y
A
C
D
Y-
V
V
N
E
A
V
Q
I
F
G
G
M
G
Y
M
R
E
S
E
I
E
R
H
Y
R
D
C
R
I
L
G
I
G
G
G
T
N
E
I
M
N
E
V
I
A
K
R
I
---------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
83.75
36%
-96
- C2 -
4M9A
1
?
A:
[12-385]
----------------------
L
Y
T
E
D
Q
R
M
I
L
D
A
A
R
A
F
C
A
E
V
L
A
P
N
A
A
Q
W
D
-
R
E
S
H
L
-
P
--
D
E
V
V
A
Q
M
G
E
L
G
F
L
G
M
I
V
P
A
D
W
G
G
S
Y
T
---
D
---
Y
V
A
Y
A
L
A
L
E
E
I
--
A
---
A
-
G
--
C
-
A
S
C
-
A
T
L
V
S
--
V
H
N
-
S
-
V
--
G
C
G
P
V
L
N
Y
G
T
T
E
Q
K
E
R
W
L
R
D
L
A
S
G
K
T
V
G
A
F
S
L
T
E
P
H
-----
H
N
L
R
T
R
A
E
L
--
R
-
D
G
-
K
W
I
L
N
G
S
K
Q
F
V
T
N
G
A
R
A
G
L
A
I
V
F
A
M
T
D
P
-
D
--
E
----
G
K
---
R
G
L
S
A
F
V
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
L
E
N
C
A
I
P
Q
E
N
L
L
G
K
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
T
G
I
A
R
A
A
F
D
R
A
R
R
Y
A
R
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
A
E
K
L
A
N
M
A
T
Q
I
N
A
A
R
L
L
T
H
H
A
A
R
L
-
R
T
A
G
L
-
P
C
--------------
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
A
--
V
C
S
D
A
I
Q
I
H
G
G
Y
G
F
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
83.59
35%
-92
- C2 -
2VIG
5
ACADS_HUMAN
A:
[10-375]
---------------------------
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
-
K
E
H
L
F
-
P
--
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
L
A
Y
A
I
A
M
E
E
I
--
S
R
G
-
C
-
A
--
S
-
T
G
V
-
I
--
M
S
--
V
N
N
-
S
-
L
--
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
--
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
R
-
A
--
L
----
Q
N
---
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
-
K
D
N
K
K
-
P
F
--------------
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
--
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
83.57
38%
-96
- C2 -
3P4T
3
?
A:
[27-399]
------------------------
T
A
E
R
E
A
L
R
K
T
V
R
A
F
A
E
R
E
V
L
P
H
A
H
E
W
E
-
R
A
G
E
I
-
P
--
R
E
L
H
R
K
A
A
E
L
G
L
L
G
A
G
F
P
E
D
A
G
G
S
G
G
---
D
---
G
A
D
P
V
V
I
C
E
E
M
--
H
Y
--
A
-
G
--
S
-
P
G
G
-
V
--
Y
A
S
L
F
T
C
-
G
-
I
--
A
V
P
H
M
I
A
S
G
D
Q
R
L
I
D
T
Y
V
R
P
T
L
R
G
E
K
I
G
A
L
A
I
T
E
P
G
G
G
S
D
V
G
H
L
R
T
R
A
D
L
--
D
-
G
D
-
H
Y
V
I
N
G
A
K
T
Y
I
T
S
G
V
R
A
D
Y
V
V
T
A
A
R
T
G
--
G
--
P
----
G
A
---
G
G
V
S
L
I
V
V
D
K
G
T
P
G
F
E
V
T
R
K
L
D
K
M
G
W
R
S
S
D
T
A
E
L
S
Y
T
D
V
R
V
P
V
A
N
L
V
G
S
E
N
T
G
F
A
Q
I
A
A
A
F
V
A
E
R
V
G
L
A
T
Q
A
Y
A
G
A
Q
R
C
L
D
L
T
V
E
W
C
R
N
R
D
T
F
G
R
P
L
I
S
R
Q
A
V
Q
N
T
L
A
G
M
A
R
R
I
D
V
A
R
V
Y
T
R
H
V
V
E
R
-
Q
L
A
G
E
-
T
N
--------------
L
-
I
A
E
V
C
F
A
K
N
T
A
V
E
A
G
E
W
V
A
N
Q
A
V
Q
L
F
G
G
M
G
Y
M
A
E
S
E
V
E
R
Q
Y
R
D
M
R
I
L
G
I
G
G
G
T
T
E
I
L
T
S
L
A
A
K
T
L
---------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
83.54
36%
-93
- C2 -
1JQI
4
ACADS_RAT
B:
[14-379]
---------------------------
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
-
K
E
H
L
F
-
P
--
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
---
D
---
Y
L
A
Y
S
I
A
L
E
E
I
--
S
R
G-
C
-
A
--
S
-
T
G
V
-
I
--
M
S
--
V
N
N
-
S
-
L
--
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
E
--
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
R
-
S
--
R
----
Q
N
---
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
-
K
D
N
K
K
-
P
F
--------------
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
--
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.36
41%
-90
- C2 -
4L1F
7
?
A:
[5-377]
-----------------------
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
-
K
A
H
I
W
-
D
--
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
---
D
---
V
L
S
Y
I
L
A
V
E
E
L
--
S
K
--
V
-
D
--
D
G
T
G
I
-
T
--
L
S
--
A
N
V
-
S
-
L
--
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
--
K
-
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
-
S
--
Q
----
G
V
---
H
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
-
K
N
E
G
K
-
P
Y
--------------
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
--
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
83.32
38%
-97
- C2 -
3OIB
17
?
A:
[27-399]
------------------------
T
A
E
R
E
A
L
R
K
T
V
R
A
F
A
E
R
E
V
L
P
H
A
H
E
W
E
-
R
A
G
E
I
-
P
--
R
E
L
H
R
K
A
A
E
L
G
L
L
G
A
G
F
P
E
D
A
G
G
S
G
G
---
D
---
G
A
D
P
V
V
I
C
E
E
M
--
H
Y
--
A
-
G
--
S
-
P
G
G
-
V
--
Y
A
S
L
F
T
C
-
G
-
I
--
A
V
P
H
M
I
A
S
G
D
Q
R
L
I
D
T
Y
V
R
P
T
L
R
G
E
K
I
G
A
L
A
I
T
E
P
G
G
G
S
D
V
G
H
L
R
T
R
A
D
L
--
D
-
G
D
-
H
Y
V
I
N
G
A
K
T
Y
I
T
S
G
V
R
A
D
Y
V
V
T
A
A
R
T
G
--
G
--
P
----
G
A
---
G
G
V
S
L
I
V
V
D
K
G
T
P
G
F
E
V
T
R
K
L
D
K
M
G
W
R
S
S
D
T
A
E
L
S
Y
T
D
V
R
V
P
V
A
N
L
V
G
S
E
N
T
G
F
A
Q
I
A
A
A
F
V
A
E
R
V
G
L
A
T
Q
A
Y
A
G
A
Q
R
C
L
D
L
T
V
E
W
C
R
N
R
D
T
F
G
R
P
L
I
S
R
Q
A
V
Q
N
T
L
A
G
M
A
R
R
I
D
V
A
R
V
Y
T
R
H
V
V
E
R
-
Q
L
A
G
E
-
T
N
--------------
L
-
I
A
E
V
C
F
A
K
N
T
A
V
E
A
G
E
W
V
A
N
Q
A
V
Q
L
F
G
G
M
G
Y
M
A
E
S
E
V
E
R
Q
Y
R
D
M
R
I
L
G
I
G
G
G
T
T
E
I
L
T
S
L
A
A
K
T
L
---------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
83.06
41%
-89
- C2 -
4L1F
5
?
B:
[5-377]
-----------------------
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
-
K
A
H
I
W
-
D
--
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
---
D
---
V
L
S
Y
I
L
A
V
E
E
L
--
S
K
--
V
-
D
--
D
G
T
G
I
-
T
--
L
S
--
A
N
V
-
S
-
L
--
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
--
K
-
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
-
S
--
Q
----
G
V
---
H
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
-
K
N
E
G
K
-
P
Y
--------------
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
--
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
82.18
38%
-96
- C2 -
3P4T
3
?
A:
[23-399]
--------------------
S
I
W
T
T
A
E
R
E
A
L
R
K
T
V
R
A
F
A
E
R
E
V
L
P
H
A
H
E
W
E
-
R
A
G
E
I
-
P
--
R
E
L
H
R
K
A
A
E
L
G
L
L
G
A
G
F
P
E
D
A
G
G
S
G
G
---
D
---
G
A
D
P
V
V
I
C
E
E
M
--
H
Y
--
A
-
G
SP
G
-
G
V
Y
----
A
S
--
L
F
T
C
G
-
I
--
A
V
P
H
M
I
A
S
G
D
Q
R
L
I
D
T
Y
V
R
P
T
L
R
G
E
K
I
G
A
L
A
I
T
E
P
G
G
G
S
D
V
G
H
L
R
T
R
A
D
L
--
D
-
G
D
-
H
Y
V
I
N
G
A
K
T
Y
I
T
S
G
V
R
A
D
Y
V
V
T
A
A
R
T
G
G
----
P
----
G
A
---
G
G
V
S
L
I
V
V
D
K
G
T
P
G
F
E
V
T
R
K
L
D
K
M
G
W
R
S
S
D
T
A
E
L
S
Y
T
D
V
R
V
P
V
A
N
L
V
G
S
E
N
T
G
F
A
Q
I
A
A
A
F
V
A
E
R
V
G
L
A
T
Q
A
Y
A
G
A
Q
R
C
L
D
L
T
V
E
W
C
R
N
R
D
T
F
G
R
P
L
I
S
R
Q
A
V
Q
N
T
L
A
G
M
A
R
R
I
D
V
A
R
V
Y
T
R
H
V
V
-
E
R
Q
L
A
G
E
T
N
L
--------------
I
A
E
V
C
F
A
K
N
T
A
V
E
A
G
E
W
--
V
A
N
Q
A
V
Q
L
F
G
G
M
G
Y
M
A
E
S
E
V
E
R
Q
Y
R
D
M
R
I
L
G
I
G
G
G
T
T
E
I
L
T
S
L
A
A
K
T
L
---------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
81.97
38%
-91
- C2 -
1BUC
3
ACDS_MEGEL
A:
[4-381]
----------------------
N
L
T
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
-
H
K
G
I
Y
-
D
--
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
DGG
D
---
V
L
S
Y
I
L
A
V
E
E
L
--
A
K
--
Y
-
D
A
G
V
-
A
I
T
----
L
S
--
A
T
V
-
S
-
L
--
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
--
N
D
D
G
-
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
K
-
S
--
K
----
G
N
---
H
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
-
C
K
K
Q
E
G
K
-
P
F
--------------
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
--
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
81.64
36%
-90
- C2 -
2D29
2
?
A:
[4-383]
--------------------
W
F
E
E
G
A
E
E
R
Q
V
L
G
P
F
R
E
F
L
K
A
E
V
A
P
G
A
A
E
R
D
-
R
T
G
A
F
-
P
--
W
D
L
V
R
K
L
A
E
F
G
V
F
G
A
L
V
P
E
A
Y
G
G
A
G
L
---
S
---
T
R
L
F
A
R
M
V
E
A
I
--
A
Y
--
Y
-
D
G
A
L
-
A
L
T
----
V
A
--
S
H
N
-
S
-
L
--
A
T
G
H
I
L
L
A
G
S
E
A
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
--
V
-
E
G
-
G
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
R
T
D
P
-
P
--
P
SPER
K
H
---
Q
G
I
S
A
F
A
F
F
R
P
E
R
G
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G
E
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
-
E
L
K
D
A
G
R
-
P
F
--------------
T
L
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
--
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
R
L
---------------------------------------------------------------------------------------------------------------------------------------------
102
Fugue
80.98
38%
-89
- C2 -
1BUC
3
ACDS_MEGEL
A:
[1-383]
-----------------
M
D
F
N
--
L
T
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
-
H
K
G
I
Y
D---
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
DGG
D
---
V
L
S
Y
I
L
A
V
E
E
L
--
A
K
--
Y
D
A
--
G
-
V
A
I
-
T
--
L
S
--
A
T
V
-
S
-
L
--
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
--
N
-
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
K
S---
K
----
G
N
---
H
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
-
K
Q
E
G
K
-
P
F
--------------
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
--
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R-------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
80.97
39%
-92
- C2 -
1BUC
3
ACDS_MEGEL
B:
[19-381]
-------------------------------------
F
G
E
K
K
L
A
P
T
V
T
E
R
D
-
H
K
G
I
Y
-
D
--
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
---
D
GGD
V
L
S
Y
I
L
A
V
E
E
L
--
A
K
YD
A
-
G
--
V
--
A
I
-
T
--
L
S
--
A
T
V
-
S
-
L
--
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
--
N
-
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
K
-
S
--
K
----
G
N
---
H
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
-
K
Q
E
G
K
-
P
F
--------------
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
--
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
117
HHSearch
80.73
30%
-100
- C2 -
3SF6
16
?
A:
[27-396]
--------------------
N
A
V
L
S
A
E
E
R
E
I
R
D
T
V
R
S
V
V
Q
R
R
I
K
P
H
I
A
S
W
Y
-
E
D
G
E
L
-
P
A
-
R
E
L
A
V
E
L
G
E
L
G
L
L
G
M
H
L
K
-
G
Y
G
C
A
G
M
---
S
---
A
V
A
Y
G
L
A
C
L
E
L
--
E
A
--
G
-
D
S
G
I
-
R
S
L
----
V
S
--
V
Q
G
-
S
-
L
--
A
M
Y
A
I
H
A
F
G
S
D
E
Q
K
D
Q
W
L
P
D
M
A
S
G
H
R
I
G
C
F
G
L
T
E
P
D
H
G
S
D
P
A
G
M
R
T
R
A
T
R
--
S
-
G
D
-
D
W
I
L
T
G
T
K
M
W
I
T
N
G
S
V
A
D
V
A
V
V
W
A
R
T
D
E
---------------
G
I
R
G
F
V
V
P
T
D
T
P
G
F
T
A
N
T
I
K
S
K
M
S
L
R
A
S
V
T
S
E
L
V
L
D
G
V
R
L
P
D
S
A
R
L
P
G
A
T
-
S
L
G
A
P
L
R
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
C
L
E
T
A
L
A
Y
A
C
S
R
E
Q
F
D
R
P
I
G
G
F
Q
L
T
Q
Q
K
L
A
D
M
T
L
E
Y
G
K
G
F
L
L
A
L
H
L
G
-
R
Q
K
D
A
G
E
-
L
A
--------------
P
E
Q
V
S
L
G
K
L
N
N
V
R
E
A
I
E
--
I
A
R
T
A
R
T
V
L
G
A
S
G
I
T
G
E
Y
P
V
M
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
T
L
I
I
G
Q
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
78.85
39%
-90
- C2 -
1BUC
3
ACDS_MEGEL
A:
[19-381]
-------------------------------------
F
G
E
K
K
L
A
P
T
V
T
E
R
D
-
H
K
G
I
Y
-
D
--
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
---
D
GGD
V
L
S
Y
I
L
A
V
E
E
L
--
A
K
Y
D
A
-
G
--
V
--
A
I
-
T
--
L
S
--
A
T
V
-
S
-
L
--
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
--
N
-
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
K
-
S
--
K
----
G
N
---
H
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
-
K
Q
E
G
K
-
P
F
--------------
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
--
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
73.33
34%
-80
- C2 -
3MDE
4
ACADM_PIG
B:
[6-378]
-----------------------
L
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
R
T
G
E
Y
-
P
--
V
P
L
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
---
G
---
I
I
D
S
C
L
I
T
E
E
L
--
A
Y
----
G
--
C
-
T
G
V
-
Q
--
T
A
--
I
E
A
-
N
-
T
LG
Q
V
P
L
I
I
G
-
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
--
K
-
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
P
-
D
--
P
----
K
A
PAS
K
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
-
I
D
S
G
R
-
R
N
--------------
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
--
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------