@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4472: (2016-02-27 )
MSLHAAAVGPSVLPDLREQVEQIIAEARRQGASACEVAVSLEQGLSTSVRQGEVETVEFNRDQGFGITLYAGQRKGSASTSATGEAAIRETVAAALAIARHTSEDECAGLADAALMARELPELDLYHPWSLSPEQAVERALACEAAAFAADKRVTKADGTTLNTHQGCRVYGNSHGFIGGYASTRHSLSCVMIAEGEGQMQRDYWYDVNRRGEALASAESIGRRAAERAASRLGARPVQTAEVPVLFAPEIAVGLFGHFLGAISGGSLYRKSSFLEGALGQRLFPEWLSIDERPHLVGALGSASFDSDGLATYAKPFVENGELVSYVLGTYSGRKLGLPSTANAGGVHNLFVSHGDEDQAALIRRMERGLLVTELMGQGVNLVTGDYSRGAAGYWVENGEIQFPVQEVTIAANLRDLFRRIVAVGKDIERRGNLHTGSVLVESMMVAGR
Atome Classification :
(20 SA)
----------------------------------------------...-----......10........-------------20---.......---------------------..----------30...-----.----....40..-......50--.........60.----....--------------...70.---......----..80..---------------...----...90.......---------------------------------------------.100---......---..110--.......--120-----------..-.....--.-------.--130....-...140.......150-----.....---------------------...160......-.170-------------------.---....--...180--.........190..-.....-200.-...-...210------------.....-.---..220-----.....---...230.......240.....-----..250.......--260..--..---...270--.......280....---.....290.----.-------------.....300..--.....----------310...-----.--...-------------------320.-----....-.-----.330......------.340.--..----...--.350----------------.-.----.....360.......--370......--.380......-----------...390..-.....---------.400.......410-----..----------.-....420..--..--...430.-......440...-....-----------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------MSL-----HAAAVG
P
S
V
L
P
D
L
R
E
Q
-------------
V
----
E
Q
I
I
A
E
A
---------------------
R
R----------QGA
S
A
-----
C
----
E
V
A
V
S
L
E
Q-GL
S
T
SVR---QG
E
V
E
T
V
E
FNRD----QG
F
G
--------------
I
T
L
Y
-A---GQRKGS----ASTSAT---------------
G
E
A
----
A
I
R
E
T
V
A
A
A
L
A
I
---------------------------------------------ARH----T
S
E
D
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C
---
A
G
L
A
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--
A
A
L
M
A
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E--L-------------PE-LDLYH--P-------W--SL
S
P
E
Q
A
-
V
E
R
A
L
A
C
E
A
A
A
FAAD------KRVTK---------------------ADGTTLNTHQ
G
C
-
R
V
Y--------------------G---NSHG--FIGG----YASTRH
S
L
S
C
V
M
I
A-EGEG
Q
-
M
Q
R
D
-
Y
W
Y-DVNRR-------------G
E
A
L
A
-
S
---
A
E
S
I
------
G
R
R
A
A
---
E
R
A
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S
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LGARPVQTAEV
P
V
L
F-----A
P
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I
A
V
G
L
F
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H
F
--
L
G
AIS--GG---SLY
R
K
S
--
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F
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A
L
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--
Q
R
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F
---
P
E
W
LSIDER----P-------------
H
L
V
G
ALGSAS--FDSD
G
----------
L
A
T
Y
A
K
-----
P
--FVE-------------------NG
E
L
-----
V
S
Y
V
-
L
-----GTYSGRKLGL------PSTAN--AG----G
V
H
--
N
L
F
V----------------S-H----GD
E
D
Q
A
A
L
I
R
R
M
E
R
G
--
L
L
V
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MGQ--GV--
N
L
VTGD-----------YSRGA-A
G
-
Y
W
V
EN---------G
E
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Q
F
P
V
Q
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A
A
-----
N
L
----------
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-
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L
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V--
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--
D
I
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RRGN-L
H
T
G
S
V
L
V
E
S
M
M-VAGR-----------------------------------------
12
HHSearch
99.80
100%
-95
- C7 -
3QTD
2
?
A:
[8-449]
----------------------------------------------------------
V
G
P
S
V
L
P
D
L
R
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Q
-------------
V
----
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R
----------
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A
-----
C
----
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A
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-
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---
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----
Q
G
F
G
--------------
I
T
L
Y
-
A
---
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----
A
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T
S
A
T
---------------
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----
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A
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---------------------------------------------
A
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----
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---
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T
K
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A
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G
T
T
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N
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Q
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C
-
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V
Y
--------------------
G
---
N
S
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G
--
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----
Y
A
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A
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Q
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M
Q
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Y
W
Y
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N
R
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-------------
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L
A
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A
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A
P
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L
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G
A
L
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--
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R
L
F
---
P
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W
L
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----
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-------------
H
L
V
G
A
L
G
S
A
S
--
F
D
S
D
G
----------
L
A
T
Y
A
K
-----
P
--
F
V
E
-------------------
N
G
E
L
-----
V
S
Y
V
-
L
-----
G
T
Y
S
G
R
K
L
G
L
------
P
S
T
A
N
--
A
G
----
G
V
H
--
N
L
F
V
----------------
S
-
H
----
G
D
E
D
Q
A
A
L
I
R
R
M
E
R
G
--
L
L
V
T
E
L
M
G
Q
--
G
V
--
N
L
V
T
G
D
-----------
Y
S
R
G
A
-
A
G
-
Y
W
V
E
N
---------
G
E
I
Q
F
P
V
Q
E
V
T
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A
A
-----
N
L
----------
R
-
D
L
F
R
R
I
V
A
V
--
G
K
--
D
I
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R
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G
N
-
L
H
T
G
S
V
L
V
E
S
M
M
-
V
A
G
R
-----------------------------------------
1
PsiBlast_PDB
99.40
98%
-95
- C7 -
3QTD
2
?
A:
[8-449]
----------------------------------------------------------
V
G
P
S
V
L
P
D
L
R
E
Q
-------------
V
----
E
Q
I
I
A
E
A
---------------------
R
R
----------
Q
G
A
S
A
-----
C
----
E
V
A
V
S
L
E
Q
-
G
L
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T
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V
R
---
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G
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V
E
T
V
E
F
N
R
D
----
Q
G
F
G
--------------
I
T
L
Y
-
A
---
G
Q
R
K
G
S
----
A
S
T
S
A
T
---------------
G
E
A
----
A
I
R
E
T
V
A
A
A
L
A
I
---------------------------------------------
A
R
H
----
T
S
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D
E
C
---
A
G
L
A
D
--
A
A
L
M
A
R
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--
L
-------------
P
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-
L
D
L
Y
H
--
P
-------
W
--
S
L
S
P
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A
-
V
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R
A
L
A
C
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A
A
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F
A
A
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------
K
R
V
T
K
---------------------
A
D
G
T
T
L
N
T
H
Q
G
C
-
R
V
Y
--------------------
G
---
N
S
H
G
--
F
I
G
G
----
Y
A
S
T
R
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S
L
S
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V
M
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A
-
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G
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Q
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M
Q
R
D
-
Y
W
Y
-
D
V
N
R
R
-------------
G
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A
L
A
-
S
---
A
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I
------
G
R
R
A
A
---
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R
A
A
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L
G
A
R
P
V
Q
T
A
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V
P
V
L
F
-----
A
P
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A
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G
L
F
G
H
F
--
L
G
A
I
S
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G
---
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--
S
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A
L
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--
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---
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----
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-------------
H
L
V
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A
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--
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D
S
D
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----------
L
A
T
Y
A
K
-----
P
--
F
V
E
-------------------
N
G
E
L
-----
V
S
Y
V
-
L
-----
G
T
Y
S
G
R
K
L
G
L
------
P
S
T
A
N
--
A
G
----
G
V
H
--
N
L
F
V
----------------
S
-
H
----
G
D
E
D
Q
A
A
L
I
R
R
M
E
R
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--
L
L
V
T
E
L
M
G
Q
--
G
V
--
N
L
V
T
G
D
-----------
Y
S
R
G
A
-
A
G
-
Y
W
V
E
N
---------
G
E
I
Q
F
P
V
Q
E
V
T
I
A
A
-----
N
L
----------
R
-
D
L
F
R
R
I
V
A
V
--
G
K
--
D
I
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R
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N
-
L
H
T
G
S
V
L
V
E
S
M
M
-
V
A
G
R
-----------------------------------------
13
HHSearch
83.31
51%
-84
- C7 -
3TV9
5
?
A:
[23-457]
-------------------------------------------------------------
N
A
R
K
I
L
E
E
A
-------------
V
----
S
T
A
L
E
L
A
---------------------
S
-----------
G
K
S
D
G
-----
A
----
E
V
A
V
S
K
T
T
-
G
I
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V
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T
R
---
Y
G
E
V
E
N
V
E
F
N
S
D
----
G
A
L
G
--------------
I
T
V
Y
-
H
---
Q
N
R
K
G
S
----
A
S
S
T
D
L
---------------
S
P
Q
----
A
I
A
R
T
V
Q
A
A
L
D
I
---------------------------------------------
A
R
Y
----
T
S
P
D
P
C
---
A
G
V
A
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--
K
E
L
L
A
F
D
--
A
-------------
P
N
-
L
D
L
F
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--
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-------
A
--
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P
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A
-
I
E
L
A
A
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A
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A
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------
K
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T
N
---------------------
T
E
G
G
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F
N
S
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Y
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V
-
K
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--------------------
G
---
N
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--
M
L
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----
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A
Y
-
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-------------
M
S
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---
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------
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A
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C
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---
R
R
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L
S
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M
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A
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A
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L
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A
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R
T
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R
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D
--
I
I
K
-------------------
D
G
I
L
-----
T
Q
W
L
-
L
-----
T
S
Y
S
A
R
K
L
G
L
------
K
S
T
G
H
--
A
G
----
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I
H
--
N
W
R
I
----------------
A
-
G
----
Q
G
L
S
F
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Q
M
L
K
E
M
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--
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V
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L
M
G
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--
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V
--
S
A
I
T
G
D
-----------
Y
S
R
G
A
-
A
G
-
F
W
V
E
N
---------
G
E
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Q
Y
P
V
S
E
I
T
I
A
G
-----
N
L
----------
K
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D
M
W
R
N
I
V
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--
G
N
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R
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N
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I
Q
C
G
S
V
L
L
P
E
M
K
-
I
--------------------------------------------
2
PsiBlast_PDB
81.25
50%
-80
- C7 -
3TV9
5
?
A:
[38-457]
-------------------------------------------------------------------------------------------
L
A
S
G
---------------------
K
S
----------
D
G
A
------------
E
V
A
V
S
K
T
T
-
G
I
S
V
S
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R
---
Y
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E
V
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N
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N
S
D
----
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L
G
--------------
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Y
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H
---
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S
----
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D
L
---------------
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----
A
I
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V
Q
A
A
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D
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---------------------------------------------
A
R
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----
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---
A
G
V
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--
K
E
L
L
A
F
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--
A
-------------
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N
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L
D
L
F
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--
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-------
A
--
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A
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A
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A
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------
K
R
I
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N
---------------------
T
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G
G
S
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N
S
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Y
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-
K
V
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--------------------
G
---
N
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----
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--
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-------------
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---
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---
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--
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--
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E
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----
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-------------
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L
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--
F
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E
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----------
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R
T
E
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R
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D
--
I
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K
-------------------
D
G
I
L
-----
T
Q
W
L
-
L
-----
T
S
Y
S
A
R
K
L
G
L
------
K
S
T
G
H
--
A
G
----
G
I
H
--
N
W
R
I
----------------
A
-
G
----
Q
G
L
S
F
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Q
M
L
K
E
M
G
T
G
--
L
V
V
T
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M
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Q
--
G
V
--
S
A
I
T
G
D
-----------
Y
S
R
G
A
-
A
G
-
F
W
V
E
N
---------
G
E
I
Q
Y
P
V
S
E
I
T
I
A
G
-----
N
L
----------
K
-
D
M
W
R
N
I
V
T
V
--
G
N
--
D
I
E
T
R
S
N
-
I
Q
C
G
S
V
L
L
P
E
M
K
-
I
--------------------------------------------
14
HHSearch
74.55
28%
-84
- C7 -
1VPB
2
?
A:
[14-451]
--------------------------------------------------------------
I
T
D
E
N
K
K
L
-------------
A
----
Q
W
A
M
D
Y
A
---------------------
L
K
----------
N
G
C
Q
A
-----
A
----
K
V
L
L
Y
S
S
S
-
N
T
S
F
E
L
R
---
D
--
M
D
R
L
Q
Q
A
S
E
----
G
G
L
S
--------------
L
S
L
Y
-
V
---
D
G
R
Y
G
S
----
I
S
T
N
R
L
---------------
N
R
K
----
E
L
E
T
F
I
K
N
G
I
D
S
---------------------------------------------
T
R
Y
----
L
A
K
D
E
A
---
R
V
L
A
D
--
P
S
R
Y
Y
K
G
--
G
K------------
P
D
-
L
K
L
Y
D
AK
F
-------
A
--
S
L
N
P
D
D
K
-
I
E
M
A
K
A
V
A
E
E
A
L
G
K
D
------
E
R
I
I
----------------------
S
V
G
S
S
Y
G
D
G
E
D
F
-
A
Y
R
--------------------
L
---
I
S
N
G
--
F
E
G
E
----
T
K
S
T
W
Y
S
L
S
A
D
I
T
I
-
R
G
E
G
E
A
R
P
S
A
-
Y
W
Y
-
E
S
S
L
Y
-------------
M
N
D
L
--
I
---
K
K
G
I
------
G
Q
K
A
L
---
E
R
V
L
R
K
L
G
Q
K
K
V
Q
S
G
K
Y
T
M
V
V
-----
D
P
M
N
S
S
R
L
L
S
P
M
--
I
S
A
L
N
--
G
S
---
A
L
Q
Q
K
N
--
S
F
L
L
N
K
L
N
--
E
K
I
A
---
S
D
R
L
T
L
T
D
E
----
P
-------------
H
L
V
K
A
S
G
A
R
Y
--
F
D
N
E
G
----------
I
A
T
E
R
R
-----
S
--
I
F
D
-------------------
K
G
V
L
-----
N
T
Y
F
-
I
-----
D
T
Y
N
A
K
K
M
G
V
------
D
P
T
I
S
--
G
------
S
S
--
I
L
V
M
----------------
E
-
T
----
G
D
K
N
L
D
G
L
I
A
G
V
E
K
G
--
I
L
V
T
G
F
N
G
G
--
N
N
--
N
S
S
T
G
D
-----------
F
S
Y
G
I
-
E
G
-
F
L
I
E
N
---------
G
K
L
T
Q
P
V
S
E
M
N
V
T
G
-----
N
L
----------
I
-
T
L
W
N
S
L
V
A
T
--
G
N
--
D
P
R
L
N
S
S
-
W
R
I
P
S
L
V
F
E
G
V
D
-
F
S
G
L
-----------------------------------------
3
PsiBlast_PDB
72.88
28%
-83
- C7 -
1VPB
2
?
A:
[29-450]
----------------------------------------------------------------------------------------------
A
---------------------
L
K
----------
N
G
C
Q
A
-----
A
----
K
V
L
L
Y
S
S
S
-
N
T
S
F
E
L
R
---
D
--
M
D
R
L
Q
Q
A
S
E
----
G
G
L
S
--------------
L
S
L
Y
-
V
---
D
G
R
Y
G
S
----
I
S
T
N
R
L
---------------
N
R
K
----
E
L
E
T
F
I
K
N
G
I
D
S
---------------------------------------------
T
R
Y
----
L
A
K
D
E
A
---
R
V
L
A
D
--
P
S
R
Y
Y
K
G
G-
K
-------------
P
D
-
L
K
L
Y
D
--
A
-------
K
FA
S
L
N
P
D
D
K
-
I
E
M
A
K
A
V
A
E
E
A
L
G
K
D
------
E
R
I
I
S
---------------------
V
-
G
S
S
Y
G
D
G
E
D
F
-
A
Y
R
--------------------
L
---
I
S
N
G
--
F
E
G
E
----
T
K
S
T
W
Y
S
L
S
A
D
I
T
I
-
R
G
E
G
E
-
A
R
P
S
A
Y
W
Y
-
E
S
S
L
Y
-------------
M
N
D
L
I
-
K
----
K
G
I
------
G
Q
K
A
L
---
E
R
V
L
R
K
L
G
Q
K
K
V
Q
S
G
K
Y
T
M
V
V
-----
D
P
M
N
S
S
R
L
L
S
P
M
--
I
S
A
L
N
--
G
S
---
A
L
Q
Q
K
N
--
S
F
L
L
N
K
L
N
--
E
K
I
A
---
S
D
R
L
T
L
T
D
E
----
P
-------------
H
L
V
K
A
S
G
A
R
Y
--
F
D
N
E
G
----------
I
A
T
E
R
R
-----
S
--
I
F
D
-------------------
K
G
V
L
-----
N
T
Y
F
-
I
-----
D
T
Y
N
A
K
K
M
G
V
------
D
P
T
I
S
--
G
S
----
S
I
----
L
V
M
----------------
E
-
T
----
G
D
K
N
L
D
G
L
I
A
G
V
E
K
G
--
I
L
V
T
G
F
N
G
G
--
N
N
--
N
S
S
T
G
D
-----------
F
S
Y
G
I
-
E
G
-
F
L
I
E
N
---------
G
K
L
T
Q
P
V
S
E
M
N
V
T
G
-----
N
L
----------
I
-
T
L
W
N
S
L
V
A
T
--
G
N
--
D
P
R
L
N
S
S
-
W
R
I
P
S
L
V
F
E
G
V
D
-
F
S
G
------------------------------------------
23
Fugue
71.68
26%
-76
- C7 -
1VL4
-
?
A:
[2-433]
-----------------------------------------------------------------
T
F
E
E
F
-------------
K
----
D
R
L
F
A
L
A
---------------------
K
K
----------
N
G
V
-
E
-----
V
----
Q
I
S
F
L
E
T
R
-
E
F
S
L
R
L
A
---
N
G
D
L
D
Q
Y
T
D
A
G
K
----
F
N
V
E
--------------
I
K
V
L
-
K
---
D
G
K
T
G
T
----
F
R
T
Q
V
L
---------------
E
N
------
P
E
K
C
F
E
E
A
L
S
N
---------------------------------------------
L
Q
V
----
K
K
E
Y
F
F
---
E
G
G
K
E
--
Y
R
E
M
--------------------
E
-
T
Y
V
G
R
--
F
-------
E
--
K
L
S
V
K
E
K
-
M
D
M
A
K
K
A
H
E
S
A
A
K
D
E
------
R
-
V
V
M
---------------------
V
P
T
V
M
Y
K
D
M
V
I
K
-
K
I
I
--------------------
T
---
N
T
L
G
--
L
D
V
E
----
S
Q
M
D
G
G
F
L
F
A
M
A
I
A
--
R
D
A
N
-
P
R
S
G
-
S
W
Y
-
E
L
A
R
T
-------------
P
E
D
L
--
N
---
P
E
E
I
------
G
K
R
A
A
---
E
E
A
I
S
L
I
G
S
K
T
I
P
S
G
K
Y
P
V
L
M
-----
R
N
T
A
L
L
D
L
M
E
M
F
--
I
P
M
I
S
--
A
E
---
N
V
Q
K
N
L
--
S
P
L
K
G
K
L
G
--
E
Q
V
G
---
N
P
A
V
S
I
K
D
L
----
P
-------------
Y
H
P
K
G
L
S
S
T
P
--
F
D
D
E
G
----------
V
P
T
T
E
K
-----
F
--
V
L
E
-------------------
N
G
V
L
-----
K
T
F
L
-
H
-----
N
L
K
T
A
R
K
E
G
V
------
E
P
T
G
N
--
G
F
VGGI
R
P
V
--
N
L
M
L
----------------
M
-
P
----
G
E
K
S
F
E
E
L
L
K
E
M
D
R
G
--
V
V
I
T
E
V
E
G
M
--
H
A
GA
N
S
I
S
G
E
-----------
F
S
L
F
A
-
K
G
-
Y
W
V
E
N
---------
G
E
I
A
H
G
V
E
D
I
T
I
S
G
-----
N
F
----------
L
-
D
L
L
R
K
I
V
L
V
--
G
N
--
D
V
K
V
S
Q
H
-
T
I
A
P
S
V
L
V
E
V
L
D
-
V
A
-------------------------------------------
4
PsiBlast_PDB
61.10
36%
-98
- C7 -
1VL4
-
?
A:
[186-433]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Y
-
E
L
A
R
T
-------------
P
E
D
L
--
N
---
P
E
E
I
------
G
K
R
A
A
---
E
E
A
I
S
L
I
G
S
K
T
I
P
S
G
K
Y
P
V
L
M
-----
R
N
T
A
L
L
D
L
M
E
M
F
--
I
P
M
I
S
--
A
E
---
N
V
Q
K
N
L
--
S
P
L
K
G
K
L
G
--
E
Q
V
G
---
N
P
A
V
S
I
K
D
L
----
P
-------------
Y
H
P
K
G
L
S
S
T
P
--
F
D
D
E
G
----------
V
P
T
T
E
K
-----
F
--
V
L
E
-------------------
N
G
V
L
-----
K
T
F
L
-
H
-----
N
L
K
T
A
R
K
E
G
V
------
E
P
T
G
N
GF
V
G
----
G
I
R
PV
N
L
M
L
----------------
M
-
P
----
G
E
K
S
F
E
E
L
L
K
E
M
D
R
G
--
V
V
I
T
E
V
E
G
M
HA
G
A
--
N
S
I
S
G
E
-----------
F
S
L
F
A
-
K
G
-
Y
W
V
E
N
---------
G
E
I
A
H
G
V
E
D
I
T
I
S
G
-----
N
F
----------
L
-
D
L
L
R
K
I
V
L
V
--
G
N
--
D
V
K
V
S
Q
H
-
T
I
A
P
S
V
L
V
E
V
L
D
-
V
A
-------------------------------------------
26
Fugue
48.99
18%
-35
- C5 -
4Q0C
-
BVGS_BORPE
A:
[66-578]
-------------------------------------------S
Q
E
L
T
L
-----
V
G
K
A
A
V
P
D
V
E
V
A
L
D
G
D
-------------
D
----
W
R
W
L
A
R
K
R
V
L
T
L
G
V
Y
A
PDIPPF
D
V
T
Y
GE
R
Y
----------
E
G
L
T
A
-----
D
----
Y
M
A
I
I
A
H
N
L
G
M
Q
A
K
V
L
---
R
Y
P
T
R
E
Q
A
L
S
A
L
----
E
S
G
Q
--------------
I
D
L
I
-
G
---
T
V
N
G
T
D
----
G
R
Q
Q
S
L
---------------
R
L
S
----
V
P
Y
A
A
D
H
P
V
I
V
M
---------------------------------------------
P
I
G
----
A
R
H
V
P
A
---
S
N
L
A
G
--
Q
R
L
A
V
D
I
NY
L
-------------
P
K
-
E
T
L
A
R
--
A
YPQ
A
T
L
H
Y
--
F
P
S
S
E
Q
A
-
L
A
A
V
A
Y
G
Q
A
D
V
F
I
G
D
-------
A
L
T
T
---------------------
S
H
L
V
S
Q
S
Y
F
N
D
V
-
R
V
V
--------------------
A
---
P
A
H
I
--
A
T
G
G
E
S
F
G
V
R
A
D
N
T
R
L
L
R
V
V
N
A
-
V
L
E
A
I
-
P
P
S
E
-
H
R
S
-
L
I
Y
R
W
-------------
G
--
L
G
-
S
---
S
I
S
L
------
D
F
A
H
P
A
Y
S
A
R
E
Q
Q
W
M
A
D
H
P
V
V
K
V
A
V
L
N
L
F
-----
A
P
F
T
L
F
R
T
D
E
Q
F
G
G
I
S
A
A
V
--
L
Q
---
L
L
Q
L
R
T
G
L
D
F
E
I
I
G
V
D
T
V
E
E
L
I
---
A
K
L
R
S
--
G
E
----
A
-------------
D
M
A
G
A
L
F
V
N
S
---
A
R
E
S
----------
F
L
S
F
S
R
-----
P
--
Y
V
R
-------------------
N
G
M
V
-----
I
V
T
R
------------
Q
D
P
D
A
------
P
V
D
A
D
--
H
L
----
D
G
R
--
T
V
A
L
----------------
V
-
R
----
N
S
A
A
I
P
L
L
Q
R
R
Y
P
Q
A
--
K
V
V
T
A
D
N
P
S
--
E
A
--
M
L
M
V
A
N
GQAD
A
V
V
----
Q
T
Q
I
S
-
A
S
-
Y
Y
V
N
R
YFAGKLRIA
S
A
L
D
L
P
P
A
E
I
A
L
A
T
TRGQ
T
E
L
----------
M
-
S
I
L
N
K
A
L
Y
S
IS
N
D
--
E
L
A
S
I
I
S
-
R
W
R
G
S
D
G
D
P
R
T
W
-
Y
A
Y
R
N
E
I
Y
L
E-----------------------------------
30
Fugue
47.59
17%
-38
- C3 -
4OV8
9
?
A:
[6-472]
----------------------------------------------
D
T
L
-----
N
D
V
I
Q
D
P
T
R
R
N
K
L
I
N
D
N
NL----------
L
----
K
G
I
I
M
G
R
---------------------
D
G
----------
P
V
P
S
S
-----
R
----
E
L
I
V
R
P
D
T
-
L
R
A
I
I
N
N
---
R
A
T
I
E
T
T
T
M
E
A
E
------
F
T
--------------
E
T
L
M
-
E
----------------
S
N
Y
---------------
N
S
A
----
S
V
K
V
S
A
P
C
I
T
A
N
---------------------------------------------
S
E
Y
----
S
E
S
S
S
F
K
N
T
E
T
E
K
S
--
M
Y
T
S
S
R
Y
--
L
-------------
F
P
-
Q
G
R
I
D
--
F
-------
T
--
T
P
D
S
G
D
V
-
I
K
L
S
P
Q
F
T
S
G
V
Q
A
A
L
------
A
K
A
T
G
---------------------
T
E
K
R
E
-
A
L
Q
N
L
F
-
Q
E
Y
--------------------
G
CVF
R
T
K
V
--
H
I
G
G
----
V
L
S
A
-
H
T
M
E
T
F
S
R
S
-
E
N
E
T
E
-
V
K
Q
D
-
V
K
A
-
G
L
E
G
A
-------------
V
K
G
W
G
-
G
---
G
A
T
A
------
G
H
-
G
N
---
T
Q
G
T
I
T
T
S
Q
N
R
K
L
N
V
K
Y
I
V
N
G
-----
G
D
Y
T
K
I
Q
N
T
E
E
W
--
V
A
S
T
N
--
Q
S
---
E
H
W
R
V
I
--
E
V
T
E
V
T
A
V
--
A
D
L
L
---
P
Q
P
I
R
G
Q
V
K
----
D
-------------
L
L
K
P
L
L
G
K
W
V
D
V
E
K
V
P
G
----------
L
E
S
L
P
V
-----
S
--
V
Y
R
P
KGAIPAG
W
F
W
L
GDTADAS
K
A
L
L
-----
V
K
P
T
-
L
-----
P
A
R
S
G
R
N
P
A
L
------
T
S
L
H
Q
--
G
S
----
G
M
T
--
E
Q
P
F
V
DLPQ
Y
Q
Y
L
S
TYFGSF
A
-
H
----
D
T
P
P
G
S
T
L
-----
R
G
--
L
R
P
D
H
-
V
L
P
--
G
R
--
Y
E
M
H
G
D
------------
T
I
S
T
-
A
V
-
Y
V
T
R
P
---------
V
D
V
P
F
P
E
D
E
---
A
F
-----
D
L
----------
K
-
S
L
V
R
V
K
L
P
G
--
S
G
--
N
P
P
K
------
P
R
S
A
L
K
K
S
M
V
-
L
F
D
------------------------------------------
31
Fugue
45.78
20%
-50
- C4 -
3V97
6
RLMKL_ECOLI
A:
[1-703]
A
M
N
S
L
F
A
S
T
A
RGL
E
E
L
L
K
T
E
L
E
N
L
GAVE
C
Q
V
V
QG
G
V
H
F
K
G
D
T
R
L
V
Y
Q
S
L
-----
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
-------------
K
V
YS
D
L
D
L
Y
L
G
V
---------------------
Q
A
----------
I
N
W
T
E
MFNPG
A
----
T
F
A
V
H
F
S
--
G
L
N
D
T
I
R
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
----
A
F
T
R
K
NLP
R
P
N
V
D
RDAPD
I
R
V
N
-
V
---
W
L
H
K
E
T
----
A
S
I
A
L
D
LSGDGLHLRGYRDRA
G
I
A
----
P
I
K
E
T
L
A
A
A
I
V
M
R
SGWQPG
T
P
L
L
D
PMCGSG
T
L
L
I
E
A
A
M
L
A
T
DRAPGLHRGRWGFSGW
A
Q
H
----
D
E
A
I
W
Q
---
E
V
K
A
E
--
A
Q
T
R
A
R
K
G
-
L
-------------
A
E
-
Y
S
S
H
F
--
Y
-------
G
--
S
D
S
D
A
R
V
-
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
I
T
F
E
V
K
D
V
A
Q
LTNPLPKGP
Y
G
T
V
L
S
N
P
P
Y
GE
S
E
P
A
L
I
A
L
H
S
L
L
G
R
I
M
--------------------
K
---
N
Q
F
G
G
W
N
L
S
L
----
F
S
A
S
P
D
L
L
S
C
L
Q
L
R
-
A
D
K
Q
Y
-
K
A
K
N
-
G
P
L
-
D
C
V
Q
K
-------------
N
Y
H
V
A
-
E
SMV
A
E
D
Y
------
T
N
R
L
R
---
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
I
E
C
Y
R
L
Y
DADLP
E
Y
N
V
A
V
D
R
Y
A
D
W
--
V
V
V
Q
E
--
Y
A
---
H
K
A
R
Q
R
--
L
F
D
I
I
A
A
T
--
I
S
V
L
GIA
P
N
K
L
V
L
K
T
R
EE
K
G
E
-------------
F
L
E
V
T
E
Y
N
A
H
--
L
W
V
N
-----------
L
T
D
Y
L
D
-----
T
GL
F
L
D
-------------------
H
R
I
A
-----
R
R
M
L
-
G
-----
Q
M
S
K
G
K
D
F
L
N
L
FSYTG
S
A
T
V
H
--
A
G
----
L
G
G
--
A
R
S
T
----------------
T
-
T
----
V
D
M
S
-
R
T
Y
L
E
W
A
E
R
N
--
L
R
L
N
G
L
T
G
R
--
A
H
--
R
L
I
Q
A
D
-----------------
C
L
-
A
W
L
R
E
---------
A
N
E
Q
F
D
L
I
F
I
D
P
P
T
-----
F
S
----------
A
F
D
V
Q
R
D
H
L
A
L
--
M
K
--
D
L
K
R
L
---
L
R
A
G
G
T
I
M
F
S
N
N
-
K
R
G
F
RMD
L
D
G
L
A
K
L
G
L
K
A
Q
E
ITQKTLSQDFARNRQIH
N
C
W
L
I
T
AA
24
Fugue
42.29
17%
-34
- C7 -
4OO3
-
?
A:
[3-441]
----------------------------------EGFTGAPGE
V
K
L
I
T
L
DPGH
F
H
A
A
L
V
Q
K
V
S
Y
P
Q
V
S
K
D
-------------
V
----
Y
V
Y
A
P
--------------------------------------
T
G
-----
F
----
D
V
D
E
H
L
K
R
-
I
Q
G
F
N
T
R
---
A
E
N
P
T
A
W
N
E
I
V
Y
----
T
G
D
D
--------------
Y
L
E
K
M
L
---
A
E
K
K
G
N
V
M
I
Q
A
G
N
N
G
K
---------------
K
T
E
----
Y
I
K
K
T
L
E
A
G
I
N
V
---------------------------------------------
L
S
D
K
PMA
I
N
S
Q
S
F
---
K
L
L
E
E
--
C
F
A
I
A
K
Q
--
K
-------------
N
I
M
L
--
Y
D
--
I
M------
T
--
E
R
N
E
I
T
T
M
L
Q
R
E
L
S
T
I
P
A
V
Y
G
E
Q
------
L
K
G
S
P
---------------------
E
E
P
----------------------------------------------------
A
I
V
K
E
S
V
H
H
L
F
K
L
-
V
D
N
K
P
-
L
T
R
P
-
V
W
Y
L
D
V
N
Q
Q
-------------
G
E
G
I
V
D
V
---
T
T
H
L
------
V
D
L
V
Q
---
W
E
A
F
P
--
D
Q
I
I
D
Y
R
K
D
I
E
L
I
D
-----
A
N
R
W
T
T
S
I
S
P
E
E
--
F
K
Q
V
T
--
G
T
---
D
A
Y
--
P
--
D
F
L
K
K
D
V
E
--
N
D
T
L
---
K
V
Y
C
N
G
D
I
V
----
Y
-------------
K
I
K
G
V
T
A
K
V
S
--
V
I
W
N
--------------
Y
T
F
-----
P
---
K
G
-------------------
G
G
D
T
-----
H
F
S
V
M
K
-----
G
--
S
K
A
D
L
V
I
------
R
Q
G
K
E
--
Q
N
----
Y
Q
P
--
E
L
F
V
----------------
E
A
V
----
K
G
V
D
L
A
A
Y
E
K
D
L
T
A
S
M
-
E
K
V
S
A
E
Y
P
G
--
V
A
--
L
N
K
V
G
D
------------------
G
-
V
W
Q
V
E
---------
I
P
A
K
Y
R
V
G
H
E
A
H
F
G
-----
Q
V
----------
T
-
E
H
F
L
D
Y
L
K
E
--
G
K
LP
D
W
E
V
P
-
N
M
L
A
K
Y
Y
T
T
T
S
A
L
D
M
A
K
A
K
T----------------------------------------
29
Fugue
40.33
17%
-44
- C6 -
3WKX
2
HYBA1_BIFL2
A:
[1-659]
-------------------------M
N
V
T
I
TS
P
F
W
K
R
R
R
D
Q
I
V
E
S
V
I
P
Y
-----
Q
W
G
V
M
N
D
E
I
D
T
T
V
P
D
D
PAGNQ
L
A
D
S
K
SH
A
V
----
A
N
L
K
V
A
A
---------------------
G
E
L
D
D
E
F
HGMVF
Q
D
S
D
V
-----
Y
K
W
L
E
E
A
A
Y
A
L
A
Y
-
H
P
D
P
E
L
K
---
A
L
C
D
R
T
V
D
L
I
A
R
A
QQS
D
G
Y
L
--------------
D
T
P
Y
-
Q
I
KS
G
V
W
A
D
R
----
P
R
F
S
L
I
---------------
Q
Q
S
H
E
M
Y
V
M
G
H
Y
I
E
A
A
V
A
Y
---------------------------------------------
H
Q
V
----
T
G
N
E
Q
A
---
L
E
V
A
K
K
M
A
D
C
L
D
A
N
--
F
GPEEGKIHGADGH
P
E
-
I
E
L
A
L
----------
A
--
K
L
Y
E
E
T
G
-
E
K
R
Y
L
T
L
S
Q
Y
L
I
D
V
R
------
G
Q
D
P
Q
---------------------
F
Y
A
K
Q
L
K
A
M
N
G
D
-
N
I
F
HGFYKPTYFQAAEPVRDQQT
A
---
D
G
H
A
--
V
R
V
G
----
Y
L
C
T
G
V
A
H
V
G
R
L
L
G
D
Q
G
L
I
D
-
T
A
K
R
-
F
W
K
-
N
I
V
T
R
RMYVTGAIGSTHV
G
E
S
F
T
-
Y
---
D
Y
D
L
PNDTMY
G
E
T
C
A
---
S
V
A
M
S
M
F
A
Q
Q
M
L
D
L
-
E
P
K
G
E
Y
-----
A
D
V
L
E
K
E
L
F
N
G
S
--
I
A
G
I
S
LD
G
K
---
Q
Y
Y
Y
V
N
--
A
L
E
T
T
P
D
G
--
L
D
N
P
---
D
R
H
H
V
L
S
H
R
----
V
DWFGCACC
P
A
N
I
A
R
L
I
A
S
V
D
R
Y
I
--
Y
T
E
R
D
GGK
T
V
L
S
H
Q
F
I
A
N
T
A
E
F
ASG
L
T
--
V
E
Q
-------------------
R
S
N
F
PWDG
H
V
E
Y
T
-
V
S
L
P
AS
A
T
D
S
S
V
R
F
G
L
------
R
I
P
G
W
--
S
R
----
G
S
Y
--
T
L
T
V
----------------
N
-
G
KPAV
G
S
L
E
D
G
F
V
Y
L
V
V
N
A
G
D
T
L
E
I
A
L
E
L
D
M
--
S
V
--
K
F
V
R
A
N
SRVRSDAG
Q
V
A
V
M
R
G
P
-
L
V
-
Y
C
A
E
Q
---------
V
D
N
P
G
D
L
W
N
Y
R
L
A
D
-----
G
V
TGAD
A
A
V
A
F
Q
A
-
D
L
L
G
G
V
D
T
V
--
D
L
--
P
A
V
R
E
H
A
-
D
E
D
D
A
P
L
Y
V
D
A
D
-
E
P
R
A
G
E
P
A
T
L
R
L
V
PYYSWANR
E
I
G
E
M
R
V
F
Q
R
R
A------------
28
Fugue
32.97
8%
22
- C7 -
3EUJ
-
B:
[63-152]
-------------------------------------------------------------
D
V
Q
T
Q
I
V
T
A
-------------
I
----
Q
A
E
L
A
H
F
---------------------
R
N
----------
T
A
Q
P
I
----------
N
L
G
A
V
L
Q
E
-
Q
L
A
R
Y
P
Q
---
S
R
H
F
D
V
A
R
I
I
V
D
----
Q
A
V
K
--------------
L
G
M
A
-
S
---
Q
D
H
Q
A
V
----
Y
P
V
W
Q
P
---------------
I
D
D
----
F
S
A
A
V
Q
A
H
L
I
D
Q
---------------------------------------------
Y
D
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
22.73
40%
274
- C7 -
2OJM
-
A:
[1-22]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
F
----------
H
-
H
I
F
R
G
I
V
H
V
--
G
K
--
T
I
H
R
L
V
T
-
G
---------------------------------------------------------
25
Fugue
21.54
36%
260
- C7 -
2OJO
-
?
A:
[1-22]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
F
----------
H
-
H
I
F
R
A
I
V
H
V
--
A
K
--
T
I
H
R
L
V
T
-
G
---------------------------------------------------------
17
HHSearch
20.76
32%
134
- C7 -
3FAJ
-
Y131_ATV
A:
[27-65]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
G
D
-----------
Y
A
G
G
A
V
K
I
L
D
M
F
E
N
---------
G
Q
L
G
Y
P
E
V
T
L
K
L
A
G
----------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
19.26
25%
60
- C7 -
3COS
3
ADH4_HUMAN
A:
[298-359]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
I
G
V
A
A
--
G
S
K
G
L
T
V
F
P
E
E
--
L
I
I
G
R
T
I
N
--
G
T
F
F
---
G
G
W
K
S
V
D
S
I
----
P
-------------
K
L
V
T
D
Y
K
N
K
K
--
F
N
L
D
A
----------
L
V
T
H
T
L
-----
P
--
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
18.33
17%
316
- C7 -
2YIZ
1
?
A:
[14-31]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
D
----
G
V
D
A
A
I
Q
G
G
L
A
R
---------------------------------------------
A
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
17.05
17%
328
- C7 -
2CC6
2
DODEC_HALS3
A:
[12-29]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
E
----
S
F
T
A
A
A
D
D
A
I
D
R
---------------------------------------------
A
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------