@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4484: (2016-02-27 )
MQWETVIGLEIHAQLATQSKIFSGSSTAFGAAPNTQASLVDLAMPGTLPVLNEEAVRMACLFGLAIDARIDRQNVFARKNYFYPDLPKGYQTSQMDHPIVGKGHLDITLEDGTTKRIGITRAHLEEDAGKSLHEDFQGMSGIDLNRAGTPLLEIVSEPDIRSAKEAVAYVKAIHALVRYLGICDGNMAEGSLRCDCNVSVRPKGQAEFGTRAEIKNVNSFRFIEKAINHEIQRQIELIEDGGKVVQETRLYDPNKDETRSMRGKEEANDYRYFPCPDLLPVVIEPEYLAKLREQLPELPVQKRERFESQYGLSAYDASVLSASREMADYFEKVQGICGDAKLAANWVMVELGSLLNKDGLEIEQSPVSAEQLGGMILRIKDNTISGKLAKMVFEAMANGEGSADQIIEAKGLKQVTDSGAIEKMLDEVLAANAEQVEQYRAADEAKRGKMFGFFVGQAMKASKGKANPQQVNELLKKKLEA
Atome Classification :
(20 SA)
.........10........20.-......-.30........40........50........60........70........80........90........100.......110.......120.......130..----..----...140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQ
W
E
T
V
I
G
L
E
I
H
A
Q
LATQSKIF-SGSSTA-FGAAPNTQ
A
S
L
V
D
LAMPGTLPVL
N
E
E
A
V
R
M
A
C
L
FG
L
A
I
D
A
R
IDR
Q
N
V
FARKNYFYPDLPKGYQTSQMDHPIVGK
G
H
L
D
I
T
LEDGTT
K
R
I
G
I
T
R
A
H
L
E
E
D
A
G
K
S
L
H
E
----
D
F----QGMSGIDLNRAGT
P
L
L
E
IVSEPD
I
R
S
A
K
E
A
V
A
Y
V
K
A
I
H
A
L
V
R
Y
L
GICDGNMAE
G
S
L
R
C
D
C
N
V
SVRPKGQAEFGTR
A
E
IKNV
N
S
F
R
F
I
E
K
A
I
N
H
E
I
Q
R
Q
I
E
L
I
EDGG
K
V
V
Q
E
T
RLYDPNK
D
E
T
R
SMRGKEEAND
Y
R
YFPCPDL
L
P
V
V
IE
P
E
Y
L
A
K
L
R
E
QLPEL
P
V
Q
K
R
E
R
F
E
S
QYGLS
A
Y
D
A
S
V
L
S
A
S
R
E
M
A
D
Y
F
E
K
V
Q
GICGDA
K
L
A
A
N
W
V
M
V
E
L
G
S
L
LNKDG
L
E
IEQSPV
S
A
E
QLG
G
M
I
L
R
I
KDNTIS
G
K
L
A
K
M
V
F
E
A
MANGEGS
A
D
Q
I
I
E
A
KG
L
K
Q
VTD
S
G
A
I
E
K
M
L
D
E
V
L
AA
N
A
E
Q
V
E
Q
Y
R
AA
D
E
A
KRG
K
M
F
G
F
F
V
G
Q
A
M
KASKGKA
N
P
Q
Q
V
N
E
L
L
K
K
K
LEA--------
1
PsiBlast_PDB
90.73
100%
-102
- C6 -
4WJ3
-
GATB_PSEAE
B:
[3-297]
--
W
E
T
V
I
G
L
E
I
H
A
Q
L
A
T
Q
S
K
I
F
-
S
G
S
S
T
A
-
F
G
A
A
P
N
T
Q
A
S
L
V
D
L
A
M
P
G
T
L
P
V
L
N
E
E
A
V
R
M
A
C
L
F
G
L
A
I
D
A
R
I
D
R
Q
N
V
F
A
R
K
N
Y
F
Y
P
D
L
P
K
G
Y
Q
T
S
Q
M
D
H
P
I
V
G
K
G
H
L
D
I
T
L
E
D
G
T
T
K
R
I
G
I
T
R
A
H
L
E
E
D
A
G
K
S
L
H
E
----
D
------
G
M
S
G
I
D
L
N
R
A
G
T
P
L
L
E
I
V
S
E
P
D
I
R
S
A
K
E
A
V
A
Y
V
K
A
I
H
A
L
V
R
Y
L
G
I
C
D
G
N
M
A
E
G
S
L
R
C
D
C
N
V
S
V
R
P
K
G
Q
A
E
F
G
T
R
A
E
I
K
N
V
N
S
F
R
F
I
E
K
A
I
N
H
E
I
Q
R
Q
I
E
L
I
E
D
G
G
K
V
V
Q
E
T
R
L
Y
D
P
N
K
D
E
T
R
S
M
R
G
K
E
E
A
N
D
Y
R
Y
F
P
C
P
D
L
L
P
V
V
I
E
P
E
Y
L
A
K
L
R
E
Q
L
P
E
L
P
V
Q
K
R
E
R
F
E
S
Q
Y
G
L
S
A
Y
D
A
S
V
L
S
A
S
R
E
M
A
D
Y
F
E
K
V
Q
G
I
C
G
D
A
K
L
A
A
N
W
V
M
V
E
L
G
S
L
L
N
K
D
G
L
E
I
E
Q
S
P
V
S
A
E
Q
L
G
G
M
I
L
R
I
K
D
N
T
I
S
G
K
L
A
K
M
V
F
E
A
M
A
N
G
E
G
S
A
--------------------------------------------------------------------------------------
43
HHSearch
90.26
49%
-91
- C6 -
3IP4
1
GATB_STAAM
B:
[1-473]
M
H
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
-
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
D
-
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
A
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
I
S
D
E
A
T
L
L
K
F
V
N
E
A
L
D
N
N
E
Q
S
V
E
D
Y
K
N
G
----
K
G
K
A
M
G
F
L
V
G
Q
I
M
K
A
S
K
G
Q
A
N
P
Q
L
V
N
Q
L
L
K
Q
E
L
D
---------
10
PsiBlast_PDB
90.13
48%
-91
- C6 -
3IP4
1
GATB_STAAM
B:
[1-473]
M
H
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
-
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
A
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
I
S
D
E
A
T
L
L
K
F
V
N
E
A
L
D
N
N
E
Q
S
V
E
D
Y
K
N
G
----
K
G
K
A
M
G
F
L
V
G
Q
I
M
K
A
S
K
G
Q
A
N
P
Q
L
V
N
Q
L
L
K
Q
E
L
D
---------
53
Fugue
88.56
49%
-90
* C6 *
3IP4
1
GATB_STAAM
B:
[1-482]
M
H
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
-
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
A
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
I
S
D
E
A
T
L
L
K
F
V
N
E
A
L
D
N
N
E
Q
S
V
E
D
Y
K
N
----
G
K
G
K
A
M
G
F
L
V
G
Q
I
M
K
A
S
K
G
Q
A
N
P
Q
L
V
N
Q
L
L
K
Q
E
L
D
K
R
LEHHHHH
45
HHSearch
86.06
44%
-81
- C6 -
3AL0
1
GATB_THEMA
B:
[1-481]
M
R
Y
R
P
V
I
G
L
E
I
H
V
Q
L
S
T
K
T
K
A
F
-
C
S
C
P
A
D
V
F
E
L
P
P
N
T
A
I
C
P
V
C
T
G
Q
P
G
A
L
P
V
P
N
E
E
M
I
R
F
A
V
K
T
A
L
A
L
N
C
K
I
H
K
Y
S
R
F
D
R
K
N
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
F
Y
P
I
A
T
E
G
F
L
E
I
D
G
D
E
-
G
R
K
K
V
R
I
R
R
L
H
L
E
E
D
A
G
K
L
V
H
E
----
G
D
SITR
A
S
Y
S
L
V
D
M
N
R
C
G
V
P
L
I
E
I
V
T
E
P
D
I
S
S
P
R
E
A
R
V
F
M
E
K
L
R
S
I
V
R
Y
L
G
V
S
T
G
D
M
E
K
G
A
L
R
C
D
A
N
I
S
V
V
D
T
E
T
G
R
Q
S
N
R
V
E
V
K
N
M
N
S
F
R
F
V
E
R
A
L
E
Y
E
F
E
R
I
V
K
A
M
E
R
G
E
D
V
E
R
E
T
R
G
W
D
M
A
T
K
I
T
V
S
M
R
G
K
E
E
E
S
D
Y
R
Y
F
P
E
P
D
I
P
P
V
V
L
S
D
E
Y
L
E
E
V
K
K
E
L
P
E
L
P
D
E
K
A
E
R
F
M
R
E
Y
G
L
P
E
Y
D
A
K
V
L
T
S
S
K
E
L
A
E
F
F
E
E
C
V
K
V
V
N
R
P
K
D
L
S
N
W
I
M
T
E
V
L
R
E
L
N
E
R
N
I
E
I
T
E
S
K
L
T
P
Q
H
F
A
D
L
F
K
L
M
D
E
G
K
I
S
I
K
I
A
K
E
I
F
P
E
V
F
E
T
G
K
M
P
S
Q
I
V
E
E
K
G
L
T
Q
I
N
D
E
K
L
I
E
E
L
V
K
K
A
M
E
Q
N
P
K
A
V
Q
D
Y
K
S
G
----
K
K
K
A
A
G
F
F
V
G
Y
V
M
R
E
T
K
G
K
A
N
P
E
L
T
N
R
I
I
Q
K
L
L
E
G
--------
3
PsiBlast_PDB
84.86
46%
-94
- C6 -
3H0M
-
GATB_AQUAE
B:
[4-412]
-
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
-
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
N
L
P
N
G
E
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
----
G
D
----
K
T
L
--
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
H
F
K
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-----------------------------------------------------------------------------
11
PsiBlast_PDB
84.41
43%
-81
- C6 -
3AL0
1
GATB_THEMA
B:
[1-480]
M
R
Y
R
P
V
I
G
L
E
I
H
V
Q
L
S
T
K
T
K
A
F
C
S
C
P
A
D
V
-
F
E
L
P
P
N
T
A
I
C
P
V
C
T
G
Q
P
G
A
L
P
V
P
N
E
E
M
I
R
F
A
V
K
T
A
L
A
L
N
C
K
I
H
K
Y
S
R
F
D
R
K
N
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
F
Y
P
I
A
T
E
G
F
L
E
I
D
G
D
E
G
R
-
K
K
V
R
I
R
R
L
H
L
E
E
D
A
G
K
L
V
H
E
GDSI
T
R
----
A
S
Y
S
L
V
D
M
N
R
C
G
V
P
L
I
E
I
V
T
E
P
D
I
S
S
P
R
E
A
R
V
F
M
E
K
L
R
S
I
V
R
Y
L
G
V
S
T
G
D
M
E
K
G
A
L
R
C
D
A
N
I
S
V
V
D
T
E
T
G
R
Q
S
N
R
V
E
V
K
N
M
N
S
F
R
F
V
E
R
A
L
E
Y
E
F
E
R
I
V
K
A
M
E
R
G
E
D
V
E
R
E
T
R
G
W
D
M
A
T
K
I
T
V
S
M
R
G
K
E
E
E
S
D
Y
R
Y
F
P
E
P
D
I
P
P
V
V
L
S
D
E
Y
L
E
E
V
K
K
E
L
P
E
L
P
D
E
K
A
E
R
F
M
R
E
Y
G
L
P
E
Y
D
A
K
V
L
T
S
S
K
E
L
A
E
F
F
E
E
C
V
K
V
V
N
R
P
K
D
L
S
N
W
I
M
T
E
V
L
R
E
L
N
E
R
N
I
E
I
T
E
S
K
L
T
P
Q
H
F
A
D
L
F
K
L
M
D
E
G
K
I
S
I
K
I
A
K
E
I
F
P
E
V
F
E
T
G
K
M
P
S
Q
I
V
E
E
K
G
L
T
Q
I
N
D
E
K
L
I
E
E
L
V
K
K
A
M
E
Q
N
P
K
A
V
Q
D
Y
K
S
G
----
K
K
K
A
A
G
F
F
V
G
Y
V
M
R
E
T
K
G
K
A
N
P
E
L
T
N
R
I
I
Q
K
L
L
E
---------
28
PsiBlast_CBE
84.22
46%
-94
- C6 -
3H0M
21
GATB_AQUAE
W:
[4-412]
-
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
-
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
N
L
P
N
G
E
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
----
G
D
----
K
T
L
--
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
H
F
K
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-----------------------------------------------------------------------------
55
Fugue
84.05
48%
-94
- C6 -
3H0L
2
GATB_AQUAE
B:
[3-412]
E
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
-
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
N
L
P
N
G
E
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
----
G
------
D
K
T
L
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
H
F
K
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-----------------------------------------------------------------------------
35
PsiBlast_CBE
83.95
46%
-94
- C6 -
3H0L
30
GATB_AQUAE
W:
[4-412]
-
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
-
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
N
L
P
N
G
E
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
----
G
D
----
K
T
L
--
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
H
F
K
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-----------------------------------------------------------------------------
44
HHSearch
83.84
47%
-94
- C6 -
3H0L
2
GATB_AQUAE
B:
[3-412]
E
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
-
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
N
L
P
N
G
E
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
----
G
------
D
K
T
L
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
H
F
K
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-----------------------------------------------------------------------------
4
PsiBlast_PDB
83.79
46%
-94
- C6 -
3H0R
-
GATB_AQUAE
B:
[4-412]
-
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
-
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
N
L
P
N
G
E
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
----
G
D
----
K
T
L
--
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
H
F
K
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-----------------------------------------------------------------------------
2
PsiBlast_PDB
83.47
46%
-94
- C6 -
3H0L
2
GATB_AQUAE
B:
[4-412]
-
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
-
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
N
L
P
N
G
E
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
----
G
D
----
K
T
L
--
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
H
F
K
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-----------------------------------------------------------------------------
21
PsiBlast_CBE
83.29
46%
-94
- C6 -
3H0R
32
GATB_AQUAE
W:
[4-412]
-
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
-
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
N
L
P
N
G
E
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
----
G
D
----
K
T
L
--
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
H
F
K
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-----------------------------------------------------------------------------
9
PsiBlast_PDB
82.72
48%
-88
- C6 -
2G5I
2
GATB_STAAM
B:
[2-411]
-
H
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
-
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
A
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
---------------------------------------------------------------------------
54
Fugue
81.24
49%
-85
- C6 -
2F2A
1
GATB_STAAM
B:
[4-411]
---
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
-
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
A
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
---------------------------------------------------------------------------
7
PsiBlast_PDB
81.04
48%
-85
- C6 -
2F2A
1
GATB_STAAM
B:
[4-411]
---
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
-
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
A
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
---------------------------------------------------------------------------
8
PsiBlast_PDB
79.69
48%
-85
- C6 -
2G5H
1
GATB_STAAM
B:
[3-400]
--
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
-
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
A
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
--------------------------------------------------------------------------------------
6
PsiBlast_PDB
79.54
48%
-84
- C6 -
2DQN
1
GATB_STAAM
B:
[3-407]
--
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
-
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
A
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
-------------------------------------------------------------------------------
5
PsiBlast_PDB
77.92
48%
-82
- C6 -
2DF4
2
GATB_STAAM
B:
[2-400]
-
H
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
-
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
A
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
--------------------------------------------------------------------------------------